666,009 results match your criteria Diabetes and Metabolic Syndrome: Clinical Research and Reviews [Journal]


Diabetes mellitus, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Genetic variation in the insulin-like growth factor (IGF) pathway may further increase the risk of colorectal cancer (CRC) associated with type 2 diabetes mellitus (T2DM). Joint effects of T2DM and genetic variation in the IGF pathway on CRC risk can increase mechanistic insights. Participants from the Netherlands Cohort Study (n=120,852) completed a baseline questionnaire in 1986 when 55-69 years old (case-cohort, n subcohort=5,000, n cases = 3,441 after 16. Read More

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http://dx.doi.org/10.1002/ijc.32365DOI Listing

Profile of Pregnant Women with Gestational Diabetes Mellitus at Increased Risk for Large for Gestational Age Newborns.

Rev Bras Ginecol Obstet 2019 Apr 24. Epub 2019 Apr 24.

Endocrinology Unit of University Hospital, Universidade Federal do Maranhão, São Luís, MA, Brazil.

Objective:  Gestational diabetes mellitus (GDM) is associated with a higher risk of perinatal morbidity and mortality, and its main complication is the occurrence of large for gestational age (LGA) newborns. The present study aims to characterize pregnant women with GDM and to identify factors associated with the occurrence of LGA newborns in this population.

Methods:  A cross-sectional study was performed based on medical records of women whose prenatal care and delivery were performed at the Maternal and Child Unit of the Hospital Universitário of the Universidade Federal do Maranhão, state of Maranhão, Brazil. Read More

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http://dx.doi.org/10.1055/s-0039-1687860DOI Listing

The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress.

Ophthalmic Res 2019 Apr 24:1-13. Epub 2019 Apr 24.

The First Clinical Medical College of Lanzhou University, Lanzhou, China.

This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db (db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. Read More

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http://dx.doi.org/10.1159/000499020DOI Listing

Higher urinary cortisol levels associated with increased cardiovascular risk.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

G Williams, Medicine/Endocrinology, Brigham and Women's Hospital, Boston, 02115, United States.

There is conflicting data on whether variations of physiologic cortisol levels associate with cardiovascular risk. We hypothesize that prior discordant findings are related to problems associated with varying sample size, techniques for assessing cardiovascular risk, and failure to adequately account for environmental factors. We utilized a large sample size, selected the Framingham risk score to compute cardiovascular risk, and performed the study in a highly controlled setting. Read More

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http://dx.doi.org/10.1530/EC-19-0182DOI Listing

Effect of cold hip baths on blood glucose levels in patients with type 2 diabetes mellitus: a pilot study.

Diabetes Metab 2019 Apr 21. Epub 2019 Apr 21.

Assitant Medical Officer/Lecturer-II, Department of Yoga, Govt. Yoga and Naturopathy Medical College and Hospital, Arumbakkam, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.diabet.2019.04.003DOI Listing

Glucoregulatory activity of Vesiculin in insulin sensitive and resistant mice.

Peptides 2019 Apr 21. Epub 2019 Apr 21.

School of Biological Sciences, New Zealand; Maurice Wilkins Centre for Molecular BioDiscovery, Auckland, New Zealand; Centre for Advanced Discovery and Experimental Therapeutics, Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, and the School of Biomedicine, the Medical School, University of Manchester, Manchester M13 9WL, UK.

Pancreatic islet-derived peptide hormones play key roles in the maintenance of systemic energy homeostasis and glucose balance, and defects in their regulation are strongly implicated in the pathogenesis of obesity and diabetes. Peptides have also been used as lead compounds for therapeutics targeting metabolic disease. It is therefore important to understand the activity and function of islet hormones in both their target tissues and the whole organism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01969781193004
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http://dx.doi.org/10.1016/j.peptides.2019.04.011DOI Listing
April 2019
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Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate lipotoxicity.

Mol Cell Endocrinol 2019 Apr 21. Epub 2019 Apr 21.

School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Perth, Western Australia, 6845, Australia. Electronic address:

Studies have reported that plasma glutamine is reduced in type 2 diabetes (T2D) patients. Glutamine supplementation improves glycaemic control, however the mechanisms are unclear. Here, we evaluated in vitro the pancreatic beta cell bioenergetic and insulin secretory responses to various levels of glutamine availability, or treatment in the presence of an inhibitor of intracellular glutamine metabolism. Read More

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http://dx.doi.org/10.1016/j.mce.2019.04.013DOI Listing

In Situ Modification of Tissue Stem and Progenitor Cell Genomes.

Cell Rep 2019 Apr;27(4):1254-1264.e7

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA 02115, USA; Joslin Diabetes Center, Boston, MA 02215, USA. Electronic address:

In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic applications and functional genetic screening. Delivery to endogenous tissue stem cells, which provide an enduring source of cell replacement during homeostasis and regeneration, is of particular interest. Here, we use a sensitive Cre/lox fluorescent reporter system to test the efficiency of genome modification following in vivo transduction by adeno-associated viruses (AAVs) in tissue stem and progenitor cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.105DOI Listing

The Distribution of Post-Void Residual (PVR) Volumes in People Seeking Care in the Symptoms of Lower Urinary Tract Dysfunction Network (LURN) Observational Cohort Study with Comparison to Asymptomatic Populations.

Urology 2019 Apr 21. Epub 2019 Apr 21.

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.

Objectives: To describe the distribution of post-void residual (PVR) volumes across patients with and without lower urinary tract symptoms (LUTS) and examine relationships between self-reported voiding symptoms, storage symptoms, and PVR.

Methods: PVR and demographic data were obtained from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) observational cohort study. Self-reported symptoms were collected using the American Urological Association Symptom Index (AUA-SI) and the LUTS Tool. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.069DOI Listing

Bile Acids as Metabolic Regulators and Nutrient Sensors.

Annu Rev Nutr 2019 Apr 24. Epub 2019 Apr 24.

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio 44272; email:

Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors that regulate lipid and energy metabolism. The brain-gut-liver axis plays an essential role in maintaining overall glucose, bile, and immune homeostasis. Fasting and feeding transitions alter nutrient content in the gut, which influences bile acid composition and pool size. Read More

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http://dx.doi.org/10.1146/annurev-nutr-082018-124344DOI Listing

Cultural Immersion Isn't About Diabetes: Understanding the Lakota Sioux Culture on the Pine Ridge Indian Reservation.

Authors:
Ali Haines

S D Med 2019 Mar;72(3):131-132

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

This article discusses the historical trauma and modern struggles of Oglala Lakota Sioux tribal members on the Pine Ridge Indian Reservation in southwestern South Dakota. In order for healthcare providers to understand why patients from this region have soaring rates of diabetes, teen pregnancies and premature death, it is important to have exposure to their culture and daily life. As part of their medical school curriculum, students at the Sanford School of Medicine take part in cultural immersion trips in order to better understand and relate to the people on the Pine Ridge Reservation. Read More

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Perceived Weight Status, Disease Risk and Weight Loss Among Young Adults.

S D Med 2019 Mar;72(3):102-108

Health and Nutritional Sciences Department, South Dakota State University.

Introduction: Accurate perception of overweight status can influence weight management practices and may contribute to perceived risk of weight-related diseases. Understanding how weight perception impacts weight management and perceived risks in young adults is important, as it is during this time that individuals are forming lifestyle behaviors and likely not burdened by chronic disease.

Methods: Cross-sectional data from 86 young adults (18-25 years) were analyzed. Read More

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Correlates of hospitalizations in internal medicine divisions among Israeli adults of different ethnic groups with hypertension, diabetes and cardiovascular diseases.

PLoS One 2019 24;14(4):e0215639. Epub 2019 Apr 24.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.

Background: Disparities in non-communicable diseases (NCDs) may affect health care utilization. We compared the correlates of hospitalizations in internal medicine divisions, of adults with NCDs, between the main population groups in Israel.

Methods: A cross-sectional study was conducted among Jews (N = 17,952) and Arabs (N = 10,441) aged ≥40 years with diabetes, hypertension or cardiovascular diseases, utilizing the computerized database of the largest health maintenance organization in Israel. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215639PLOS

The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression.

PLoS One 2019 24;14(4):e0215601. Epub 2019 Apr 24.

Department of Medicine, University of Washington, Seattle, WA, United States of America.

During periods in which glucose absorption from the gastrointestinal (GI) tract is insufficient to meet body requirements, hepatic gluconeogenesis plays a key role to maintain normal blood glucose levels. The current studies investigated the role in this process played by vasodilatory-associated phosphoprotein (VASP), a protein that is phosphorylated in hepatocytes by cAMP/protein kinase A (PKA), a key mediator of the action of glucagon. We report that following stimulation of hepatocytes with 8Br-cAMP, phosphorylation of VASP preceded induction of genes encoding key gluconeogenic enzymes, glucose-6-phosphatase (G6p) and phosphoenolpyruvate carboxykinase (Pck1), and that VASP overexpression enhanced this gene induction. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215601PLOS
April 2019
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Association between serum 25-hydroxyvitamin D and diabetic kidney disease in Chinese patients with type 2 diabetes.

PLoS One 2019 24;14(4):e0214728. Epub 2019 Apr 24.

Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.

Objective: The objective was to assess the association between 25-hydroxyvitamin D (25OHD) level and diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes.

Methods: Data pertaining to 351 in-patients with type 2 diabetes were collected. Subjects were classified into three groups based on the level of urinary albumin-to-creatinine ratio (UACR). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214728PLOS

Post-Streptococcal Glomerulonephritis in Two Patients Following Deceased Donor Kidney Transplant.

Am J Case Rep 2019 Apr 24;20:587-591. Epub 2019 Apr 24.

Piedmont Transplant Institute, Piedmont Hospital, Atlanta, GA, USA.

BACKGROUND Post-streptococcal glomerulonephritis (PSGN) is a well-known cause of renal injury. This disease is caused by a prior infection with specific nephritogenic strains of group A beta-hemolytic streptococcus resulting in formation of immune complexes in the glomeruli. Clinical presentation can range from asymptomatic, microscopic hematuria to the nephritic syndrome which is defined by red to brown urine, nephrotic range proteinuria, edema, hypertension, and acute kidney injury. Read More

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http://dx.doi.org/10.12659/AJCR.914304DOI Listing

Reply to the Letter to the Editor: methodological issues on the clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large-for-gestational-age (LGA) fetuses in non-diabetic pregnancies.

J Perinat Med 2019 Apr 24. Epub 2019 Apr 24.

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1515/jpm-2019-0110DOI Listing

Methodological issues on the clinical importance of the 75-g glucose tolerance test (GTT) in the prediction of large for gestational age (LGA) fetuses in non-diabetic pregnancies.

J Perinat Med 2019 Apr 24. Epub 2019 Apr 24.

Chamran Highway, Velenjak, Daneshjoo Blvd, Department of Clinical Epidemiology, School of Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, PC: 198353-5511, I.R. Iran.

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http://dx.doi.org/10.1515/jpm-2019-0095DOI Listing

The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats.

J Basic Clin Physiol Pharmacol 2019 Apr 24. Epub 2019 Apr 24.

Department of Physiology, School of Medicine, Selçuk University, Konya, Turkey.

Background The objective of this investigation was to examine the impact of silymarin supplementation on locomotion, anxiety-related behavior, learning, and memory via several behavioral tests, such as open field, elevated plus maze, and Morris water maze tests in streptozotocin-induced diabetic rats. Methods The rats were divided into the control, diabetes, silymarin, and diabetes plus silymarin groups. On the 30th-35th days of the study, several behavioral tests were performed and blood and brain tissue samples were taken and brain-derived neurotrophic factor (BDNF) and histone deacetylase 3 (HDAC3) levels were analyzed. Read More

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http://dx.doi.org/10.1515/jbcpp-2018-0109DOI Listing

Extending expressed RNA genomics from surgical decision making for cytologically indeterminate thyroid nodules to targeting therapies for metastatic thyroid cancer.

Cancer Cytopathol 2019 Apr 24. Epub 2019 Apr 24.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncy.22132
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http://dx.doi.org/10.1002/cncy.22132DOI Listing
April 2019
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Improving glucocorticoid replacement profiles in adrenal insufficiency.

Clin Endocrinol (Oxf) 2019 Apr 24. Epub 2019 Apr 24.

Department of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, Commonwealth Building, London, UK.

There is an increased mortality associated with adrenal insufficiency despite glucocorticoid replacement therapy with a standardised mortality ratio greater than two. The cause of the increased mortality is yet to be definitively elucidated, but may be due to excess steroid exposure, or replacement regimens that are uncoupled from the normal physiological cortisol profile. Cortisol secretion follows an ultradian pattern which is not possible to reproduce using oral replacement. Read More

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http://dx.doi.org/10.1111/cen.13999DOI Listing

The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs.

J Cell Physiol 2019 Apr 24. Epub 2019 Apr 24.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Diabetes mellitus (DM) and cancer are global problems carrying huge human, social, and economic impact. Type 2 diabetes (T2DM) is associated with an increased risk for a number of cancers, including breast, pancreatic, and liver cancer. Moreover, adverse drug reactions are higher in paitents with cancer with T2DM compared to cancer patients without T2DM. Read More

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http://dx.doi.org/10.1002/jcp.28644DOI Listing

Feasibility of integrating a dental hygienist into an inpatient medical team for patients with diabetes mellitus.

J Public Health Dent 2019 Apr 24. Epub 2019 Apr 24.

Division of Dentistry, Massachusetts General Hospital, Boston, MA, USA.

Patients who are hospitalized face a high risk of poor oral health and experience a decline in oral hygiene over the course of hospitalization. Due to the documented links between diabetes and periodontal disease as well as the prevalence of diabetes in the hospitalized population, patients with type 2 diabetes mellitus were chosen as the population of interest for a pilot program of dental hygienist-led care provision in the hospital. Inclusion criteria were established by agreement of a dentist and physician. Read More

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http://dx.doi.org/10.1111/jphd.12320DOI Listing

Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events.

JAMA Surg 2019 Apr 24. Epub 2019 Apr 24.

Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts.

Importance: The benefits of antimicrobial prophylaxis are limited to the first 24 hours postoperatively. Little is known about the harms associated with continuing antimicrobial prophylaxis after skin closure.

Objective: To characterize the association of type and duration of prophylaxis with surgical site infection (SSI), acute kidney injury (AKI), and Clostridium difficile infection. Read More

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2019.0569DOI Listing
April 2019
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Usage Patterns of GlucoNote, a Self-Management Smartphone App, Based on ResearchKit for Patients With Type 2 Diabetes and Prediabetes.

JMIR Mhealth Uhealth 2019 Apr 24;7(4):e13204. Epub 2019 Apr 24.

Department of Biomedical Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Preventing progression from prediabetes to diabetes-or slowing the progression of diabetes-is an urgent task worldwide. Previous studies have shown that mobile health (mHealth) may powerfully support self-management for patients with type 2 diabetes. Certainly, mHealth improves health care efficiency and gives patients convenient access to self-management of their own health. Read More

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http://mhealth.jmir.org/2019/4/e13204/
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http://dx.doi.org/10.2196/13204DOI Listing
April 2019
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How Do Smart Device Apps for Diabetes Self-Management Correspond with Theoretical Indicators of Empowerment? An Analysis of App Features.

Int J Technol Assess Health Care 2019 Jan;35(2):150-159

Nanyang Technological University,Singapore(Wee Kim Wee School of Communication and Information).

Objectives: Smart device apps for diabetes have the potential to support patients in their daily disease management. However, uncertainty exists regarding their suitability for empowering patients to improve self-management behaviors. This paper addresses a general research gap regarding theoretically based examinations of empowerment in diabetes research, by examining how diabetes app features correspond with conceptual indicators of empowerment. Read More

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http://dx.doi.org/10.1017/S0266462319000163DOI Listing
January 2019

Alpha-Tocopherol and contrast-induced nephropathy: a meta-analysis of randomized controlled trials.

Int J Vitam Nutr Res 2019 Apr 24:1-9. Epub 2019 Apr 24.

8 Diabetology, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.

Contrast-induced nephropathy (CIN) is a relevant cause of acute renal dysfunction and is associated with an increased morbidity and mortality. Purpose: Verify the effect of α-tocopherol pre-treatment on CIN prevention in subjects with chronic kidney disease. A Medline/Embase and clinicaltrials. Read More

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https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000573
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http://dx.doi.org/10.1024/0300-9831/a000573DOI Listing
April 2019
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Obesity related changes in cardiac structure and function: role of blood pressure and metabolic abnormalities.

Acta Cardiol 2019 Apr 24:1-8. Epub 2019 Apr 24.

a Dipartimento PROMISE , University of Palermo, School of Medicine , Palermo , ltaly.

Background: It has been reported that changes in cardiac structure and ventricular function associated with obesity have to be attributable to hemodynamic and non-hemodynamic alterations. Accordingly, the aim of this was to evaluate left ventricular hypertrophy (LVH) prevalence and its effect on left ventricular systolic and diastolic function in a cohort of obese patients.

Materials And Methods: LV internal diameter (LVID), left ventricular mass (LVM) and LVM/height(LVMI), relative wall thickness (RWT), LV ejection fraction (LVEF), E/A ratio, isovolumic relaxation time, deceleration time of E velocity by echocardiography and pulsed-wave Doppler and total circulating adiponectin (ADPN) by radioimmunoassay were measured in 319 obese subjects with and without LVH. Read More

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http://dx.doi.org/10.1080/00015385.2019.1598638DOI Listing

Time Lag and Accuracy of Continuous Glucose Monitoring During High Intensity Interval Training in Adults with Type 1 Diabetes.

Diabetes Technol Ther 2019 Apr 24. Epub 2019 Apr 24.

1 LMC Diabetes & Endocrinology, Toronto, Canada.

This study investigated the accuracy of real-time continuous glucose monitoring (rtCGM) during high intensity interval training (HIIT) in patients with type 1 diabetes (T1D). Seventeen participants with T1D, using multiple daily injections (MDI) with basal insulin glargine 300 U/mL (Gla-300), completed four fasted HIIT sessions over 4 weeks while wearing a Dexcom rtCGM G4 Platinum system. Each exercise consisted of high intensity interval cycling and multimodal training over 25 min. Read More

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http://dx.doi.org/10.1089/dia.2018.0387DOI Listing

The G allele of the rs12050217 polymorphism in the BDKRB1 gene is associated with protection for diabetic retinopathy.

Curr Eye Res 2019 Apr 24. Epub 2019 Apr 24.

c Biochemical Pharmacology Lab, Center for Experimental Research , Hospital de Clínicas de Porto Alegre , Porto Alegre , Rio Grande do Sul , Brazil .

Purpose: The plasma kallikrein kinin system is activated during vascular injury caused by diabetic retinopathy (DR), being involved in hyperpermeability and inflammation. Bradykinin B1 receptor (B1R) is expressed in human retina and its levels are increased in murine models of diabetes. Experimental studies reveal that B1R antagonists ameliorate retinal injury caused by diabetes in rodents. Read More

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http://dx.doi.org/10.1080/02713683.2019.1610178DOI Listing

Comparing modalities of conducting the six-minute walk test in healthy children and adolescents.

Minerva Pediatr 2019 Jun;71(3):229-234

Division of Cardiology, Pulmology, Allergology, and Cystic Fibrosis, Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria.

Background: The 6-minute walk test (6MWT) in children can be performed in the conventional way, or by using a measuring wheel. This study aimed to compare these test modalities and to determine influencing factors.

Methods: The study included 317 healthy children (172 boys) between 6 and 15 years from elementary schools and high schools, who were randomly assigned to perform a 6MWT either with or without a measuring wheel according to the guidelines of the American Thoracic Society. Read More

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http://dx.doi.org/10.23736/S0026-4946.18.05185-XDOI Listing

GLYCEMIC CONTROL AND BONE MINERAL DENSITY IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES.

Pediatr Diabetes 2019 Apr 24. Epub 2019 Apr 24.

Hans Christian Andersen Children's Hospital, Odense University Hospital, Denmark.

Background/aim: Fracture risk is increased in patients with type 1 diabetes. We aimed to evaluate bone mineral density (BMD) and to identify risk factors associated to lower BMD in Danish children and adolescents with type 1 diabetes.

Methods: In this cross-sectional study, BMD and BMD Z-score were determined by dual-energy X-ray absorptiometry (DXA) from a cohort of otherwise healthy children and adolescents with type 1 diabetes. Read More

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http://dx.doi.org/10.1111/pedi.12861DOI Listing

Trajectories of hemoglobin A1c and BMI z-score over four decades among 2-18 year olds with type 1 diabetes.

Pediatr Diabetes 2019 Apr 24. Epub 2019 Apr 24.

University of Colorado School of Medicine, Departments of Pediatrics and Epidemiology, Denver CO, US.

Objectives: To determine trajectories of glycemic control and BMI z-score in a large pediatric sample with type 1 diabetes (T1D) over a 38-year period, and to evaluate sex differences and temporal changes in the prevalence of these trajectories.

Methods: We conducted a longitudinal, retrospective study of 7002 2-18 year olds with T1D followed between 1978 and 2016 at a single center. Group-based modeling was used to identify trajectories for hemoglobin A1c (HbA1c) and BMI z-score. Read More

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http://dx.doi.org/10.1111/pedi.12862DOI Listing

Response to Wi, D. (2018) Letter: Sleep disturbance in people with diabetes: A concept analysis.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

College of Nursing, University of Illinois at Chicago, Chicago, IL, U.S.

We would like to thank Dahee Wi for the interest and comments on our recent publication (Zhu et al., 2018). We welcome this dynamic dialogue on defining the concept of sleep disturbance in people with diabetes. Read More

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http://dx.doi.org/10.1111/jocn.14886DOI Listing

The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation.

APMIS 2019 Apr 24. Epub 2019 Apr 24.

Viro-Immunology Research Unit, Department of Infectious Diseases, Rigshospitalet, University Hospital of Copenhagen, 2100 Kbh Ø, Copenhagen, Denmark.

Tingstedt JL, Hove-Skovsgaard M, Gaardbo J, Ullum H, Nielsen SD, Gelpi M. The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation. Chronic immune activation and inflammation are constant findings in people living with HIV (PLWH) and contribute to the risk of non-AIDS-related morbidities, including cardiovascular diseases (CVD). Read More

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http://dx.doi.org/10.1111/apm.12956DOI Listing

Unmet medical needs in Intermittent Claudicantion with Diabetes and Coronary Artery Disease - a 'real-world' analysis on 21,197 PAD patients.

Clin Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Division of Vascular Medicine, Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure Medicine, University Hospital Muenster, Cardiol, Muenster, Germany.

Background: Peripheral artery disease (PAD) is frequently co-prevalent with coronary artery disease (CAD) and diabetes (DM). The study aims to define the burden of CAD and/ or DM in PAD patients at moderate stages and further to evaluate its impact on therapy and outcome.

Methods: Study is based on health insurance claims data of the BARMER reflecting an unselected "real-world" scenario. Read More

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http://dx.doi.org/10.1002/clc.23186DOI Listing

Design of a geospatial model applied to Health management.

Rev Bras Enferm 2019 Mar-Apr;72(2):420-426. Epub 2019 Apr 18.

Pontifícia Universidade Católica do Paraná. Curitiba-PR, Brasil.

Objective: To identify geographically the beneficiaries categorized as prone to Type 2 Diabetes Mellitus, using the recognition of patterns in a database of a health plan operator, through data mining.

Method: The following steps were developed: the initial step, the information survey. Development, construction of the process of extraction, transformation, and loading of the database. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0589DOI Listing

Omalizumab in An 8-Year-Old Boy With Diabetes Mellitus and Refractory Chronic Spontaneous Urticaria.

J Investig Allergol Clin Immunol 2019 Apr;29(2):144-146

Department of Pediatrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital, Martin, Slovakia.

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http://dx.doi.org/10.18176/jiaci.0351DOI Listing

Examining and Understanding Value: The Impact of Preoperative Characteristics, Intraoperative Variables, and Postoperative Complications on Cost of Robotic-Assisted Laparoscopic Radical Prostatectomy.

J Endourol 2019 Apr 24. Epub 2019 Apr 24.

University of Kentucky Medical Center, 12253, Urology , 800 Rose St. , Room MS237 , Lexington, Kentucky, United States , 40536-0293 ;

Introduction And Objective: Quality-based reimbursement continues to gain popularity as value-based care becomes more prominent. Our goal is to describe the impact of preoperative characteristics, intraoperative variables, and postoperative complications on the cost of robotic-assisted laparoscopic radical prostatectomy (RALP).

Methods: Using our institution's National Surgical Quality Improvement Program (NSQIP) data, we identified minimally invasive prostatectomies performed January 2012 to March 2017. Read More

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http://dx.doi.org/10.1089/end.2019.0066DOI Listing

Comparative analysis of mRNA expression profiles in Type 1 and Type 2 diabetes mellitus.

Epigenomics 2019 Apr 24. Epub 2019 Apr 24.

Department of Critical-care Medicine, Shandong Provincial Qianfoshan Hospital (Qianfoshan Hospital Affiliated to Shandong University), Jinan 250014, China.

We aimed to understand the individual and shared features of Type 1 diabetes (T1D) and Type 2 diabetes (T2D) by analyzing the gene expression profile. An integrated analysis was performed with microarray datasets for T1D and T2D. Compared with normal control, shared and specific differentially expressed genes (DEGs) in T1D and T2D were obtained. Read More

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http://dx.doi.org/10.2217/epi-2018-0055DOI Listing

Outcomes of open heart surgery in patients with endstage renal disease.

Kidney Res Clin Pract 2019 Apr 24;38(1). Epub 2019 Apr 24.

Division of Nephrology, Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.

Background: Cardiovascular diseases of chronic dialysis patients are often undertreated because of their higher surgical risk. This study aimed to assess mortality and morbidity after open heart surgery in chronic dialysis patients compared to those with normal renal function and identify risk factors for postoperative outcomes.

Methods: We retrospectively analyzed 2,432 patients who underwent open heart surgery from 2002 to 2017 and collected data from 116 patients (38 patients on dialysis and 78 age-, sex-, and diabetes mellitus status-matched control patients with normal kidney function). Read More

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http://dx.doi.org/10.23876/j.krcp.18.0123DOI Listing

[Glucose metabolism modeling of diabetes patients with different intensities of aerobic exercise: an in silico study].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2019 Apr;36(2):274-280

Complex Systems Research Center, Shanxi University, Taiyuan 030006, P.R.China;Shanxi Key Laboratory of Mathematical Techniques and Big Data Analysis on Disease Control and Prevention, Shanxi University, Taiyuan 030006,

Exercise is vital for diabetics to improve their blood glucose level. However, the quantitative relationship between exercise modes (including types, intensity, time, etc.) and the blood glucose is still not clear. Read More

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http://dx.doi.org/10.7507/1001-5515.201805066DOI Listing

Endophthalmitis after Cataract Surgery in Korea: A Nationwide Study Evaluating Incidence and Risk Factors in a Korean Population.

Yonsei Med J 2019 May;60(5):467-473

Department of Ophthalmology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Purpose: To assess the nationwide rate of acute postoperative endophthalmitis (APE) after cataract extraction in Korea and to evaluate potential risk factors thereof.

Materials And Methods: Nationwide insurance claims data from July 2014 to June 2017 were reviewed. All patients with phacoemulsification or extracapsular/intracapsular cataract extraction were included. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.5.467DOI Listing

Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus.

J Cachexia Sarcopenia Muscle 2019 Apr 23. Epub 2019 Apr 23.

Foundation for Diabetes Research in Older People, Diabetes Frail Ltd, Luton, UK.

Background: Type 2 diabetes, a highly prevalent chronic disease, is associated with increasing frailty and functional decline in older people. We aimed to evaluate the effectiveness of a multimodal intervention on functional performance in frail and pre-frail participants aged ≥70 years with type 2 diabetes mellitus.

Methods: The MID-Frail study was a cluster-randomized multicenter clinical trial conducted in 74 trial sites across seven European countries. Read More

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http://dx.doi.org/10.1002/jcsm.12432DOI Listing

Synthesis and Application of KγT Peptide Nucleic Acids.

Methods Mol Biol 2019 ;1973:131-145

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Displaying ligands in a succinct and predictable manner is essential for elucidating multivalent molecular-level binding events. Organizing ligands with high precision and accuracy provides a distinct advantage over other ligand-display systems, such as polymers, because the number and position of the ligand(s) can be accurately and fully characterized. Here we describe the synthesis of peptide nucleic acids (PNAs), which are oligonucleotide mimics with a pseudopeptide backbone that can hybridize to oligonucleotides through Watson-Crick base pair to form highly predictable and organized scaffold for organizing a ligand. Read More

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http://dx.doi.org/10.1007/978-1-4939-9216-4_8DOI Listing
January 2019

Effect of Warfarin on Ischemic Stroke, Bleeding, and Mortality in Patients with Atrial Fibrillation Receiving Peritoneal Dialysis.

Am J Cardiovasc Drugs 2019 Apr 23. Epub 2019 Apr 23.

Division of Cardiology, Kaiser Permanente Los Angeles Medical Center, 1526 North Edgemont Street, 2nd Floor, Los Angeles, CA, 90027, USA.

Background: There is limited information on the risks and benefits of anticoagulation in patients with atrial fibrillation receiving peritoneal dialysis.

Objective: The aim was to determine the risk of mortality, ischemic stroke, and bleeding associated with warfarin use in patients with atrial fibrillation receiving peritoneal dialysis.

Patients And Methods: This is a retrospective observational study of a multi-ethnic cohort of patients with atrial fibrillation receiving peritoneal dialysis in the United States. Read More

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http://dx.doi.org/10.1007/s40256-019-00347-3DOI Listing

Association of Interleukin-6 -174G/C Polymorphism with the Risk of Diabetic Nephropathy in Type 2 Diabetes: A Meta-analysis.

Curr Med Sci 2019 Apr 23;39(2):250-258. Epub 2019 Apr 23.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Previous studies reported the association between interleukin-6 (IL-6) -174G/C gene polymorphism and the risk of diabetic nephropathy in type 2 diabetes mellitus (T2DN). However, the results remain controversial. In the present study, we conducted a meta-analysis to further examine this relationship between IL-6-174G/C gene polymorphism and T2DN. Read More

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http://dx.doi.org/10.1007/s11596-019-2027-1DOI Listing

Association between SLC2A9 Genetic Variants and Risk of Hyperuricemia in a Uygur Population.

Curr Med Sci 2019 Apr 23;39(2):243-249. Epub 2019 Apr 23.

The Key Laboratory of Metabolic Diseases, Department of Education, Xinjiang Uygur Autonomous Region and the First Affiliated Hospital, Xinjiang Medical University, Urumqi, 830054, China.

EN: Summary]This study aimed to test the effects of five single nucleotide polymorphisms within SLC2A9 on uric acid level in a special ethnic population, the Uygurs in Xinjiang, China. According to our inclusion and exclusion criteria, Uygur adults from Xinjiang constituted the study population. There were 1053 Uygur adults with hyperuricemia and 1373 normal Uygur adults who served as controls. Read More

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http://dx.doi.org/10.1007/s11596-019-2026-2DOI Listing

Increased Risk of Chronic Kidney Diseases in Patients with Metabolic Syndrome: A 3-year Prospective Cohort Study.

Curr Med Sci 2019 Apr 23;39(2):204-210. Epub 2019 Apr 23.

Department of Endocrine and Metabolic Diseases, Affiliated Hospital of Guizhou Medical University, Huaxi Qu, Guizhou, 550004, China.

The relationship of metabolic syndrome (MS) and its components with incident chronic kidney disease (CKD) and rapid decline of estimated glomerular filtration rate (eGFR) was investigated. A total of 10 140 patients participating in the epidemiological study (Risk Evaluation of Cancers in Chinese Diabetic Individuals, REACTION) of risk factors of type 2 diabetes in China were followed up for 3 years, with MS being diagnosed by adult treatment panel III (ATPIII) combined with waist circumference in Asian population and renal function being evaluated by eGFR <60 mL·min(1.73 m and rapid decline of eGFR ≤30%. Read More

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http://dx.doi.org/10.1007/s11596-019-2020-8DOI Listing
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