657,723 results match your criteria Diabetes and Metabolic Syndrome: Clinical Research and Reviews [Journal]


Adverse events and their risk factors 90 days after cervical spine surgery: analysis from the Michigan Spine Surgery Improvement Collaborative.

J Neurosurg Spine 2019 Feb 15:1-13. Epub 2019 Feb 15.

Departments of1Neurosurgery.

OBJECTIVEThe Michigan Spine Surgery Improvement Collaborative (MSSIC) is a statewide, multicenter quality improvement initiative. Using MSSIC data, the authors sought to identify 90-day adverse events and their associated risk factors (RFs) after cervical spine surgery.METHODSA total of 8236 cervical spine surgery cases were analyzed. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18666DOI Listing
February 2019

Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice.

J Nutr Biochem 2019 Jan 18;66:63-69. Epub 2019 Jan 18.

Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

Gut microbiota contributes to the biological activities of berry anthocyanins by transforming them into bioactive metabolites, and anthocyanins support the growth of specific bacteria, indicating a two-way relationship between anthocyanins and microbiota. In the present study, we tested the hypothesis that strawberry supplementation alters gut microbial ecology in diabetic db/db mice. Control (db/+) and diabetic (db/db) mice (7 weeks old) consumed standard diet or diet supplemented with 2. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.01.004DOI Listing
January 2019

Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach.

J Nutr Biochem 2018 Dec 12;66:52-62. Epub 2018 Dec 12.

Nutritional Genomics Laboratory, LabGeN, School of Applied Sciences, UNICAMP, São Paulo, Brazil; Nutrigenomics and Lipids Research Center, CELN, School of Applied Sciences, UNICAMP, São Paulo, Brazil. Electronic address:

GPR120 and GPR40 were recently reported as omega-3 (ω3) receptors with anti-inflammatory properties. Physical exercise could increase the expression of these receptors in the liver, improving hepatic metabolism in obesity and type 2 diabetes. Our aim was to investigate GPR120/40 in the liver of lean and obese mice after acute or chronic physical exercise, with or without the supplementation of ω3 rich flaxseed oil (FS), as well as assess the impact of exercise and FS on insulin signaling and inflammation. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2018.12.003DOI Listing
December 2018

Atherogenic cytokines and chemokines in chronic hepatitis C are not associated with the presence of cardiovascular diseases.

Cytokine 2019 Feb 13;115:24-31. Epub 2019 Feb 13.

Faculdade de Farmácia, Laboratório de Pesquisa em Imunologia, Universidade Federal da Bahia, Brazil. Electronic address:

There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CHC patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183048
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http://dx.doi.org/10.1016/j.cyto.2018.12.005DOI Listing
February 2019
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Depression is associated with diabetes status of family members: NHANES (1999-2016).

J Affect Disord 2019 Feb 6;249:121-126. Epub 2019 Feb 6.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Background: The majority of the studies in this area focus on the psychological impact of having diabetic children or adolescents on parents, while a limited number of studies have investigated the effect of diabetes on the mental health status of family members in the general population. Thus, the aim of the current study is to explore the possible association between mental health disorders (depression, anxiety and panic) and diabetes status of family members among a national sample of adults in the United States.

Methods: Our analysis included 1,787 and 25,574 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2016, respectively. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.019DOI Listing
February 2019

Socioeconomic differences in the associations between diabetes and hospital admission and mortality among older adults in Europe.

Econ Hum Biol 2019 Jan 17;33:89-100. Epub 2019 Jan 17.

Department of Economics and GEN, University of Cantabria. Avenue. Los Castros, s/n, Santander, CP 39005, Spain. Electronic address:

The aim of this study is to explain the trends in socioeconomic inequality and diabetes outcomes in terms of hospital admission and death in old European people. The sample includes 73,301 individuals, across 16 European countries taken from the Survey of Health, Ageing and Retirement in Europe (SHARE). People being diagnosed of diabetes were more likely to be admitted to hospital than those without diabetes, although its effect dropped after controlling for clinical and functional complications. Read More

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http://dx.doi.org/10.1016/j.ehb.2018.12.007DOI Listing
January 2019

Reliability of peak foot pressure in patients with previous diabetic foot ulceration.

Gait Posture 2019 Feb 4;70:6-11. Epub 2019 Feb 4.

Department of Physiotherapy, Singapore General Hospital, Singapore. Electronic address:

Background: Previous reliability studies on peak plantar pressure measurements in patients with previous diabetic foot ulceration (DFU) did not stratify their analyses according to whether the foot had a previous ulcer.

Research Question: Does test-retest reliability of peak foot pressure measurements from the various foot regions differ between the ulcerated and non-ulcerated feet?

Methods: Data from 23 participants with peripheral neuropathy and healed plantar DFU were analysed in this test-retest reliability comparison study. Plantar pressure was evaluated on two sessions using Pedar-X in-shoe system, with a mean of 7. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.02.001DOI Listing
February 2019

Arriba por la vida Estudio (AVE): Study protocol for a standing intervention targeting postmenopausal Latinas.

Contemp Clin Trials 2019 Feb 13. Epub 2019 Feb 13.

University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.

Background: Postmenopausal Latinas are a growing population group in the US who are at high risk for cardiovascular disease. Epidemiological studies have shown that excessive sitting is related to cardiovascular disease risk. Older women sit for prolonged periods and most individuals do not meet physical activity guidelines. Read More

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http://dx.doi.org/10.1016/j.cct.2019.02.004DOI Listing
February 2019

Perceptions of Canadian vascular surgeons toward pharmacologic risk reduction in patients with peripheral artery disease: 2018 update.

Ann Vasc Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Vascular Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, and University of Toronto, Toronto, ON, Canada; Department of Surgery, King Saud University, Riyadh, Kingdom of Saudi Arabia; King Saud University-Li Ka Shing Collaborative Research Program, Toronto, Ontario, Canada; and Riyadh, Kingdom of Saudi Arabia. Electronic address:

Background: Vascular surgeons have a central role in managing peripheral artery disease (PAD). This study assessed their knowledge, attitudes, and behaviours regarding pharmacologic risk reduction in PAD and results were compared to a similar 2004 survey conducted by our group.

Methods: An online questionnaire was administered to 161 active members of the Canadian Society for Vascular Surgery. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.034DOI Listing
February 2019

Objective physical activity and physical performance in middle-aged and older adults.

Exp Gerontol 2019 Feb 13. Epub 2019 Feb 13.

Framingham Heart Study, Framingham, MA, USA; Department of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA.

Background: Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important determinant of physical performance in older adults. Our objective was to explore associations of PA/SED with physical performance across mid-older age in adults without overt mobility disability. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.003DOI Listing
February 2019

Diabetes and cancer: debating the link through Ca/cAMP signalling.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669, Vila Clementino, São Paulo, SP, Brazil, CEP: 04039-032. Electronic address:

The incidence of both cancer and diabetes is dramatically increasing in worldwide population, costing many millions from governments into expenditures related to medical health systems. Diabetes has been clinically linked to an increased risk for developing several types of cancer. The cellular mechanisms involved in this link are still under intensive debate in literature. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.017DOI Listing
February 2019

Assessment of risk of fasting during Ramadan under optimal diabetes care, in high-risk patients with diabetes and coronary heart disease through the use of FreeStyle Libre flash continuous glucose monitor (FSL-CGMS).

Diabetes Res Clin Pract 2019 Feb 13. Epub 2019 Feb 13.

Endocrine department, Dubai Hospital, United Arab Emirates.

Aim: Most of Muslims patients with diabetes and Coronary Heart Disease (CHD) elect to fast in Ramadan, but the actual risk in this subset of patients with diabetes is largely unknown. We aimed to understand the safety of fasting in CHD patients with diabetes insisting on fasting Ramadan under optimal care. We also monitored the change in biophysical and biochemical parameters of these patients before and after Ramadan. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.038DOI Listing
February 2019

Longitudinal Study of Peripapillary Thinning in Sickle Cell Hemoglobinopathies.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL. Electronic address:

Purpose: To determine the rate of retinal nerve fiber layer (RNFL) thinning in patients with sickle cell hemoglobinopathies. Design; Prospective cohort study METHODS: Sixty-seven patients averaging 35.8±11. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.006DOI Listing
February 2019

Pancreatic pericytes originate from the embryonic pancreatic mesenchyme.

Dev Biol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

The embryonic origin of pericytes is heterogeneous, both between and within organs. While pericytes of coelomic organs were proposed to differentiate from the mesothelium, a single-layer squamous epithelium, the embryonic origin of pancreatic pericytes has yet to be reported. Here, we show that adult pancreatic pericytes originate from the embryonic pancreatic mesenchyme. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.020DOI Listing
February 2019

Comparisons of bone density and body composition among adolescents with anorexia nervosa and atypical anorexia nervosa.

Int J Eat Disord 2019 Feb 16. Epub 2019 Feb 16.

Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Objective: To compare bone mineral density (BMD) and body composition among adolescents: (a) with atypical anorexia nervosa (AAN) versus anorexia nervosa (AN) and (b) those with and without a prior history of overweight.

Method: Electronic medical records of patients 9-20 years with AN or AAN who underwent dual-energy x-ray absorptiometry scans were retrospectively reviewed and analyzed.

Results: A total of 286 adolescents with AN or AAN were included. Read More

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http://dx.doi.org/10.1002/eat.23048DOI Listing
February 2019

Recent advances in the pathogenesis of microvascular complications in diabetes.

Arch Pharm Res 2019 Feb 15. Epub 2019 Feb 15.

Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu, South Korea.

Millions of people worldwide have diabetes, which is diagnosed by fasting blood glucose levels exceeding 126 mg/dL. Regardless of the type of diabetes, prolonged hyperglycemia is damaging to several organs including eyes, kidneys, nerve, and/or heart. The damages are associated with a high risk of morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s12272-019-01130-3DOI Listing
February 2019

Improvement in Quality of Care for Patients with Type 2 Diabetes in Hungary Between 2008 and 2016: Results from Two Population-Based Representative Surveys.

Diabetes Ther 2019 Feb 15. Epub 2019 Feb 15.

Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.

Introduction: Due to the increasing trends of recent decades, diabetes prevalence has reached a frequency of 1/11 adults worldwide. However, this disadvantageous trend has not been accompanied by worsened outcome indicators; better short-term (e.g. Read More

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http://dx.doi.org/10.1007/s13300-019-0582-xDOI Listing
February 2019

Three-stage laparoscopic surgery in a morbidly obese patient with Hinchey III diverticulitis: a case report.

Surg Case Rep 2019 Feb 15;5(1):24. Epub 2019 Feb 15.

Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan.

Background: Perforated diverticulitis with purulent peritonitis (Hinchey III diverticulitis) has traditionally been treated with a Hartmann's procedure in order to avoid the considerable postoperative morbidity and mortality associated with one-stage resection and primary anastomosis. Although there have been reports regarding laparoscopic lavage as the initial treatment of perforated Hinchey III diverticulitis, a formal treatment strategy has not been established yet. We performed a three-stage surgery, including laparoscopic lavage and drainage with diverting ileostomy (first stage), laparoscopic sigmoidectomy (second stage), and ileostomy closure (third stage) in a morbidly obese patient with Hinchey III diverticulitis. Read More

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http://dx.doi.org/10.1186/s40792-019-0588-7DOI Listing
February 2019

Pathologic findings of the removed stomach during sleeve gastrectomy.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Bariatric Surgery, Orlando Regional Medical Center, Orlando Health, Orlando, FL, USA.

Background: Laparoscopic sleeve gastrectomy (LSG) is the preferred surgical intervention to treat morbid obesity. Despite the rising popularity of LSG, little is known on the histopathologic findings of the resected partial stomach specimens. Our study aims to identify prevalent pathologic findings of the removed stomach and explore the association between patient characteristics and abnormal findings. Read More

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http://dx.doi.org/10.1007/s00464-019-06689-yDOI Listing
February 2019

First-in-class positron emission tomography tracer for the glucagon receptor.

EJNMMI Res 2019 Feb 15;9(1):17. Epub 2019 Feb 15.

Antaros Medical AB, Uppsala Science Park, Dag Hammarskjölds Väg 14B, Mölndal, SE-751 83, Uppsala, Sweden.

The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy, especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP-1/GCG) receptor agonists. However, currently, there are no suitable biomarkers that reliably demonstrate GCG receptor target engagement.

Methods: Two potent GCG receptor peptide agonists, S01-GCG and S02-GCG, were labeled with positron emission tomography (PET) radionuclide gallium-68. Read More

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http://dx.doi.org/10.1186/s13550-019-0482-0DOI Listing
February 2019

Diabetes Management in Older Adults With Chronic Kidney Disease.

Curr Diab Rep 2019 Feb 15;19(3):11. Epub 2019 Feb 15.

Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, CA, USA.

Purpose Of Review: Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management.

Recent Findings: Although there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities. Read More

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http://dx.doi.org/10.1007/s11892-019-1128-3DOI Listing
February 2019

Agonistic autoantibodies against B2-adrenergic receptors correlating with macrovascular disease in longstanding diabetes type 2.

Acta Diabetol 2019 Feb 15. Epub 2019 Feb 15.

Department of Internal Medicine III, Jena University Hospital, Jena, Germany.

Aims: Agonistic autoantibodies directed against adrenergic, endothelin, and angiotensin receptors are known as pathogenic factors in disease-causing vascular impairments such as Buergers' disease, dilatative cardiomyopathy, dementia, and preeclampsia. Diabetes mellitus also causes micro- and macrovascular damages, but pathogenesis is still not fully understood. Following indications for a pathogenic role of the mentioned antibodies from our preliminary investigations, we investigated the prevalence in a bigger cohort of patients with longstanding diabetes with or without diabetic complications. Read More

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http://dx.doi.org/10.1007/s00592-019-01296-8DOI Listing
February 2019

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries.

Arch Gynecol Obstet 2019 Feb 15. Epub 2019 Feb 15.

Division of Obstetrics and Prenatal Medicine, Department of Medicine and Surgery (DIMEC) Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

Purpose: To estimate the impact of increasing pre-pregnancy Body Mass Index (BMI) on the risk of adverse maternal and perinatal outcomes, in patients who delivered in an Italian tertiary care Obstetric department.

Methods: Data, related to women who delivered at Sant'Anna Hospital, Turin, between 2011 and 2015, were collected retrospectively from the hospital database. According to BMI, women were considered as normal weight, overweight, and class 1, 2 and 3 obese (WHO criteria). Read More

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http://dx.doi.org/10.1007/s00404-019-05093-0DOI Listing
February 2019

Aging alters phenotypic traits of thyroid dysfunction in male mice with divergent effects on complex systems but preserved thyroid hormone action in target organs.

J Gerontol A Biol Sci Med Sci 2019 Feb 16. Epub 2019 Feb 16.

Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany.

Clinical manifestation of hyperthyroidism and hypothyroidism vary with age, with an attenuated, oligosymptomatic presentation of thyroid dysfunction (TD) in older patients. We asked, whether in rodents TD phenotypes are influenced by age and whether this involves changes in systemic and/or organ thyroid hormone (TH) signaling. Chronic hyper- or hypothyroidism was induced in male mice at different life stages (5, 12, 20 months). Read More

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http://dx.doi.org/10.1093/gerona/glz040DOI Listing
February 2019

MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis.

Carcinogenesis 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen Pauwelsstrasse, Germany.

In Western countries, a rising incidence of obesity and type 2 diabetes correlates with an increase of non-alcoholic steatohepatitis (NASH)-a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). NASH is associated with chronic liver injury, triggering hepatocyte death and enhanced translocation of intestinal bacteria, leading to persistent liver inflammation through activation of Toll-like receptors and their adapter protein myeloid differentiation factor 88 (MyD88). Therefore, we investigated the role of MyD88 during progression from NASH to HCC using a mouse model of chronic liver injury (hepatocyte-specific deletion of nuclear factor κB essential modulator, Nemo; NemoΔhepa). Read More

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http://dx.doi.org/10.1093/carcin/bgy173DOI Listing
February 2019

Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling.

Exp Mol Med 2019 Feb 15;51(2):18. Epub 2019 Feb 15.

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea.

Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces mesangial cell proliferation; however, its effect and molecular mechanisms remain unknown. Read More

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http://dx.doi.org/10.1038/s12276-019-0217-3DOI Listing
February 2019

Performance of HbA1c versus oral glucose tolerance test (OGTT) as a screening tool to diagnose dysglycemic status in high-risk Thai patients.

BMC Endocr Disord 2019 Feb 15;19(1):23. Epub 2019 Feb 15.

Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.

Background: Dysglycemic status defined by prediabetes and diabetes is known to be related with future risk of diabetic complications and cardiovascular diseases. Herein, we aimed to determine the diagnostic accuracy of glycated hemoglobin (HbA1c) when compared with oral glucose tolerance test (OGTT) as a reference test in identifying dysglycemic status among high-risk Thai patients receiving care in an out-patient setting.

Methods: An 11-year retrospective cross-sectional study of high-risk Thai patients who underwent OGTT during 2007-2017 was analysed. Read More

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http://dx.doi.org/10.1186/s12902-019-0339-6DOI Listing
February 2019

The Health and economic effects of light rail lines: design, methods, and protocol for a natural experiment.

BMC Public Health 2019 Feb 15;19(1):200. Epub 2019 Feb 15.

Center for Health Research, Kaiser Permanente Northwest, Oregon, Portland, USA.

Background: The health impacts of community design have been studied extensively over the past two decades. In particular, public transportation use is associated with more walking between transit stops and shops, work, home and other destinations. Change in transit access has been linked with physical activity and obesity but seldom to health outcomes and associated costs, especially within a causal framework. Read More

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http://dx.doi.org/10.1186/s12889-019-6518-6DOI Listing
February 2019

First case report of thyroid abscess caused by Helicobacter cinaedi presenting with thyroid storm.

BMC Infect Dis 2019 Feb 15;19(1):166. Epub 2019 Feb 15.

Division of Pulmonary Medicine, Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, 4-2-22 Nishikicho, Tachikawa, Tokyo, 190-8531, Japan.

Background: Helicobacter cinaedi is a microaerobic Gram-negative spiral-shaped bacterium that causes enteritis, cellulitis, and bacteremia in both immunocompromised and immunocompetent patients. While there have been increasing numbers of reported H. cinaedi infections recently, there has been no thyroid abscess case caused by H. Read More

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http://dx.doi.org/10.1186/s12879-019-3808-7DOI Listing
February 2019

[Consideration of Application of Insulin Pen Needles and Supervision].

Authors:
Na Zhan

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):63-64

Center for Medical Device Evaluation, CFDA, Beijing, 100081.

With the increasing incidence of diabetes mellitus in China, hypodermic injection of artificial insulin to control blood sugar has been popularized. Insulin pen needles are widely used in hospitals, communities and families. This article attempts to explore and think about the harm and countermeasures brought about by the reuse of insulin pen needles from the perspective of medical device supervision. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.016DOI Listing
January 2019

Impact of gender on echocardiographic characteristics in heart transplant recipients.

Clin Physiol Funct Imaging 2019 Feb 15. Epub 2019 Feb 15.

Lund University, Department of Clinical Sciences Lund, Cardiology, Lund, Sweden.

Aims: Assessment following heart transplantation (HTx) is routinely performed using transthoracic echocardiography. Differences in long-term mortality following HTx related to donor-recipient matching have been reported, but effects of gender on cardiac size and function are not well studied. The aims of this study were to evaluate differences in echocardiographic characteristics of HTx recipients defined by gender. Read More

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http://dx.doi.org/10.1111/cpf.12565DOI Listing
February 2019

Gallbladder: the Metabolic Orchestrator.

Diabetes Metab Res Rev 2019 Feb 15:e3140. Epub 2019 Feb 15.

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.

It is commonly held that the gallbladder (GB) is not indispensable for life. However, recent studies strongly suggest that GB removal can lead to the development of metabolic syndrome (MetS). With the recent recognition of the role of bile acids (BAs) in systemic metabolic regulation, it is worthwhile to re-examine the function of the GB, which can be regarded as the physiological 'pacemaker' of BA flow. Read More

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http://dx.doi.org/10.1002/dmrr.3140DOI Listing
February 2019

Matrine attenuates high-fat diet-induced in vivo and ox-LDL-induced in vitro vascular injury by regulating the PKCα/eNOS and PI3K/Akt/eNOS pathways.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, PR China.

Lipid metabolism disorders lead to vascular endothelial injury. Matrine is an alkaloid that has been used to improve obesity and diabetes and for the treatment of hepatitis B. However, its effect on lipid metabolism disorders and vascular injury is unclear. Read More

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http://dx.doi.org/10.1111/jcmm.14180DOI Listing
February 2019

The James Lind Alliance research priorities for diabetes.

Authors:
N Oliver R I G Holt

Diabet Med 2019 Mar;36(3):267-268

Diabetic Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/dme.13917DOI Listing

PPAR-γ: Its ligand and its regulation by microRNAs.

J Cell Biochem 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily. PPARs are categorized into three subtypes, PPARα, β/δ, and γ, encoded by different genes, expressed in diverse tissues and participate in various biological functions and can be activated by their metabolic derivatives in the body or dietary fatty acids. The PPAR-γ also takes parts in the regulation of energy balance, lipoprotein metabolism, insulin sensitivity, oxidative stress, and inflammatory signaling. Read More

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http://dx.doi.org/10.1002/jcb.28419DOI Listing
February 2019

Factors associated with readmission and mortality in adult patients with skin and soft tissue infections.

Int J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Clinical Microbiology Department, Son Llàtzer Hospital, Balearic Islands, Spain.

Background: Skin and soft tissue infections (SSTIs) are a common cause of consultation, and complicated cases require hospitalization. We describe factors that are related to readmission and/or mortality of hospitalized patients diagnosed with SSTIs.

Methods: Retrospective review of hospital-admitted patients with a diagnosis of cellulitis, abscess, hidradenitis, fasciitis, and Fournier's gangrene. Read More

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http://dx.doi.org/10.1111/ijd.14390DOI Listing
February 2019

PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.

Proc Natl Acad Sci U S A 2019 Feb 15. Epub 2019 Feb 15.

Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC, Canada H2W 1R7;

Precise modulation of hepatic glucose metabolism is crucial during the fasting and feeding cycle and is controlled by the actions of circulating insulin and glucagon. The insulin-signaling pathway requires insulin receptor substrate 1 (IRS1) and IRS2, which are found to be dysregulated in diabetes and obesity. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1A) is a fasting-induced transcriptional coactivator. Read More

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http://dx.doi.org/10.1073/pnas.1815150116DOI Listing
February 2019

Identification Potential Plasma Biomarkers and Metabolic Dysfunction for Unstable Angina Pectoris and Its Complication based on Global Metabolomics.

Biosci Rep 2019 Feb 15. Epub 2019 Feb 15.

Beijing University of Chinese Medicine, Beijing, China

Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the diagnosis, prognosis, and treatment of UA remains a challenge in the clinic. A global metabolomics research based on ultra performance liquid chromatography (UPLC) combined with time of flight mass spectrometry (Q-TOF/MS) was performed to discover the metabolic profile of health controls, UA patients, and UA patients with diabetes mellitus (DM), and screen for potential biomarkers. Read More

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http://dx.doi.org/10.1042/BSR20181658DOI Listing
February 2019

The search for a PKR code - Differential regulation of Protein Kinase R activity by diverse RNA and protein regulators.

RNA 2019 Feb 15. Epub 2019 Feb 15.

National Institute of Diabetes and Digestive and Kidney Diseases

The interferon-inducible protein kinase R (PKR) is a key component of host innate immunity that restricts viral replication and propagation. As one of the four eIF2alpha kinases that sense diverse stresses and direct the integrated stress response (ISR) crucial for cell survival and proliferation, PKR's versatile roles extend well beyond antiviral defense. Targeted by numerous host and viral regulators made of RNA and proteins, PKR is subject to multiple layers of endogenous control and external manipulation, driving its rapid evolution. Read More

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http://dx.doi.org/10.1261/rna.070169.118DOI Listing
February 2019

Increased Clinical Sensitivity and Specificity of Plasma Protein -Glycan Profiling for Diagnosing Congenital Disorders of Glycosylation by Use of Flow Injection-Electrospray Ionization-Quadrupole Time-of-Flight Mass Spectrometry.

Clin Chem 2019 Feb 15. Epub 2019 Feb 15.

Division of Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA

Background: Congenital disorders of glycosylation (CDG) represent 1 of the largest groups of metabolic disorders with >130 subtypes identified to date. The majority of CDG subtypes are disorders of -linked glycosylation, in which carbohydrate residues, namely, -glycans, are posttranslationally linked to asparagine molecules in peptides. To improve the diagnostic capability for CDG, we developed and validated a plasma -glycan assay using flow injection-electrospray ionization-quadrupole time-of-flight mass spectrometry. Read More

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http://dx.doi.org/10.1373/clinchem.2018.296780DOI Listing
February 2019

Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: confirmation between eye screening and comprehensive eye examination diagnoses.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Glaucoma Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Aims: To evaluate agreement between ocular findings of a telemedicine eye screening (visit 1) with diagnoses of a comprehensive eye examination (visit 2).

Methods: A primary care practice (PCP)-based telemedicine screening programme incorporating fundus photography, intraocular pressure (IOP) and clinical information was conducted. Eligible individuals were African American, Hispanic/Latino or Asian over the age of 40; Caucasian individuals over age 65; and adults of any ethnicity over age 40 with a family history of glaucoma or diabetes. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313451DOI Listing
February 2019

Targeted assessment of methylation identifies a rapidly recurrent, routinely fatal molecular subtype of adrenocortical carcinoma.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Internal Medicine - Metabolism, Endocrinology & Diabetes, University of Michigan-Ann Arbor

Purpose: Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with few therapies; however, patients with locoregional disease have variable outcomes. The Cancer Genome Atlas project on ACC (ACC-TCGA) identified that cancers of patients with homogeneously rapidly recurrent or fatal disease bear a unique CpG island hypermethylation phenotype, "CIMP-high." We sought to identify a biomarker that faithfully captures this subgroup. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2693DOI Listing
February 2019

Obesity, visceral adiposity and carotid atherosclerosis.

J Diabetes Complications 2019 Jan 17. Epub 2019 Jan 17.

Department of Cardiology, School of Health Sciences, Medical University of Silesia, Katowice, Poland.

Carotid artery atherosclerosis is a complex and multifactorial chronic disease. Our aim was to assess the associations between obesity, fat depots and carotid artery stenosis (CAS) in patients with high cardiovascular (CV) risk.

Methods: The study group included 391 patients (F/M: 136/255 pts. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.002DOI Listing
January 2019

Prognostic Significance of Obesity and Diabetes Mellitus in Women With Brain Metastases From Breast Cancer Should Be Revisited.

Clin Breast Cancer 2019 Jan 23. Epub 2019 Jan 23.

MKA Breast Cancer Clinic, Tepe Prime, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.clbc.2019.01.004DOI Listing
January 2019

Prognostic factors in patients with active non-variceal upper gastrointestinal bleeding.

Arab J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address:

Background And Study Aims: Acute upper gastrointestinal bleeding is one of the main causes of hospitalisation. The purpose of this study was to determine the prognostic factors in non-variceal upper gastrointestinal bleeding.

Patients And Methods: Clinical outcomes, demographic and laboratory variables of the subjects were collected from the HIS software and national code with the SQL format from three hospitals in Qazvin. Read More

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http://dx.doi.org/10.1016/j.ajg.2019.01.001DOI Listing
February 2019

MODY 3 diabetes, not every early onset diabetes is type 1 diabetes.

Endocrinol Diabetes Nutr 2019 Feb 12. Epub 2019 Feb 12.

Unidad de Diabetes Pediátrica, Hospital Universitario Miguel Servet, Zaragoza, España.

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http://dx.doi.org/10.1016/j.endinu.2018.12.003DOI Listing
February 2019

Lipid control and associated risk factors, before suffering from the first cardiovascular event.

Clin Investig Arterioscler 2019 Feb 12. Epub 2019 Feb 12.

Atención primaria, Costa de Ponent, Institut Català de la Salut, Barcelona, España.

Objective: To ascertain the degree of lipidic control before the first cardiovascular accident in population attended during 2013 at Primary Care. To analyze the distribution of these events depending on control intervals of cholesterol LDL (LDL-chol), cholesterol HDL (HDL-chol) and triglycerides (TG).

Method: A multicentric cross-sectional, descriptive study on above 18-year-old people attended at the centres of the Primari Care Service (PCS) Baix Llobregat Nord, who had suffered a first cardiac or cerebral ischemic attack from 01/01/2013 to 31/12/2013. Read More

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http://dx.doi.org/10.1016/j.arteri.2018.12.002DOI Listing
February 2019

The accuracy evaluation of four blood glucose monitoring systems according to ISO 15197:2003 and ISO 15197:2013 criteria.

Prim Care Diabetes 2019 Feb 12. Epub 2019 Feb 12.

Department of Endocrinology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address:

Self-monitoring of blood glucose is recommended to monitor glycaemic levels for the prevention and treatment of diabetes mellitus.The accuracy of blood glucose monitoring systems (BGMS) directly affects the health of the patients. In this study, we evaluated the accuracy of four different blood glucose monitoring systems, including Gold-Accu Meter, Nova StatStrip Xpress Glucose Hospital Meter, Freestyle Optium Neo H and Accu-Chek Performa according to ISO15197:2003 and ISO15197:2013 criteria. Read More

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http://dx.doi.org/10.1016/j.pcd.2018.12.010DOI Listing
February 2019

Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: A proof of concept study.

J Sci Med Sport 2019 Jan 31. Epub 2019 Jan 31.

School of Health and Life Sciences, Glasgow Caledonian University, UK; Department of Movement and Sports Science, Ghent University, Belgium.

Objectives: This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control.

Design: Randomised three-treatment, two-period balanced incomplete block trial.

Methods: Twelve adults with type 2 diabetes (age, 60±11years; body mass index, 30. Read More

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http://dx.doi.org/10.1016/j.jsams.2019.01.017DOI Listing
January 2019

Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Number 1, Youyi Road Yuzhong District, 400042, Chongqing, China. Electronic address:

Glucagon-like peptide-1 (GLP-1) and its receptor, GLP-1R, are valuable tools in the therapy of type 2 diabetes mellitus. Although GLP-1R stimulation is also potentially applicable to neurological disorders, few investigators have evaluated its beneficial effects in neurological disease models. Thus, we aimed to look into the antiepileptic effects of GLP-1R on epilepsy and its underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.028DOI Listing
February 2019
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