650,144 results match your criteria Diabetes Therapy [Journal]


Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Gastroenterology and Hepatology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: The recommendation in regards to screening for non-alcoholic fatty liver disease (NAFLD) among type 2 diabetes mellitus (T2DM) patients differs in major guidelines.

Aim: To study the prevalence of NALFD and advanced fibrosis among T2DM patients.

Methods: Cross-sectional study of consecutive adult T2DM patients attending the Diabetes Clinic of a university hospital. Read More

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December 2018

Risk factors for death among patients with Chikungunya virus infection during the outbreak in northeast Brazil, 2016-2017.

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará-UFC. Fortaleza, Ceará, Brazil.

Background: Chikungunya virus (CHIKV) infection is a current public health problem. The aim of this study was to investigate risk factors for death among patients with CHIKV infection during a large epidemic in northeast Brazil.

Methods: This is a cross-sectional study with all registered cases of CHIKV in Ceara, Brazil, during 2016-2017. Read More

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December 2018

Dynamic Changes of Retinal Microaneurysms in Diabetes Imaged With In Vivo Adaptive Optics Optical Coherence Tomography.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5932-5940

Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.

Purpose: To prospectively monitor microaneurysms (MAs) in three dimensions using adaptive optics optical coherence tomography (AOOCT).

Methods: Patients with diabetes mellitus and parafoveal MAs were included in this longitudinal study. At baseline, MAs were identified in standard fluorescein angiography (FA) and subsequently imaged with an AOOCT prototype, incorporated into an AO fundus camera (RTX1, Imagine Eyes) device. Read More

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December 2018

Prevalence and associated risk factors of periodic limb movement in sleep in two German population-based studies.

Sleep 2018 Dec 14. Epub 2018 Dec 14.

Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-Universität Münster, Münster, Germany.

Study Objectives: Periodic limb movements in sleep (PLMS) are frequent motor phenomena; however, population-based data are scarce. We assessed the prevalence of PLMS and factors associated with PLMS within two German population-based cohorts, the SHIP-TREND and BiDirect.

Methods: Single-night polysomnography was performed on 1107 subjects recruited from the general population (mean age: 52. Read More

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December 2018

Aerobic Exercise Training Alleviates Renal Injury by Interfering with Mitochondrial Function in Type-1 Diabetic Mice.

Med Sci Monit 2018 Dec 14;24:9081-9089. Epub 2018 Dec 14.

Department of Sports, Shanghai University of Traditional Chinese Medicine, Shanghai, China (mainland).

BACKGROUND Diabetic nephropathy was one of the most serious and harmful diabetic complications, characterized by progressive loss of renal function and renal fibrosis. Aerobic exercise training is an important non-pharmacologic method to prevent and treat diabetes mellitus and diabetic complications. MATERIAL AND METHODS Intraperitoneal (i. Read More

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December 2018

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Gastroenterology 2018 Dec 11. Epub 2018 Dec 11.

Molecular & Integrative Physiology, University of Michigan School of Public Health, Ann Arbor MI; Internal Medicine Division of Gastroenterology, University of Michigan School of Public Health, Ann Arbor MI; Rogel Cancer Center. University of Michigan Medical School, Ann Arbor MI. Electronic address:

Background & Aims: Neutrophils are among the most prevalent immune cells in the microenvironment of colon tumors, are believed to promote growth of colon tumors, and their numbers correlate with outcomes of patients with colon cancer. Trials of inhibitors of neutrophil trafficking are under way in patients with cancer, but it is not clear how neutrophils contribute to colon tumorigenesis.

Methods: Colitis-associated colon cancer was induced mice with conditional deletion of neutrophils (LysMCre;Mcl1) and wild-type littermates (LysMCre;Mcl1, control mice) by administration of azoxythmethane and/or dextran sulfate sodium. Read More

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December 2018

Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia.

Physiol Behav 2018 Dec 11. Epub 2018 Dec 11.

Kocaeli University Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey; Kocaeli University, Experimental Medical Research and Application Centre, Kocaeli, Turkey.

Diabetes is one of the risk factors for the development of vascular dementia (VD), leading to endothelial dysfunction and cognitive impairment. Resveratrol has been shown to have antioxidant, antiinflammatory, and neuroprotective effects. The previous studies have also reported that resveratrol improves cognitive and vascular endothelial functions in several pathological conditions. Read More

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December 2018

Significance of Obstetrical History with Future Cardiovascular Disease Risk.

Am J Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiovascular Sciences, Morsani College of Medicine 12901 Bruce B. Downs Blvd. Tampa, FL 33612.

The maternal cardiovascular system undergoes profound changes to support the increasing demands of fetal growth during pregnancy. An accumulating body of evidence has shown that common pregnancy complications, including gestational diabetes mellitus, preeclampsia, low birth weight, and preterm delivery, can be associated with future cardiovascular adverse events in mothers. Factors such as glucose metabolism, hyperlipidemia, inflammatory markers, large and small vessel stiffness/functionality have been linked with these pregnancy conditions. Read More

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December 2018

Risk Factors for Severe Dry Eye Disease: Crowdsourced Research Using DryEyeRhythm.

Ophthalmology 2018 Dec 11. Epub 2018 Dec 11.

Juntendo University Faculty of Medicine, Department of Ophthalmology, Tokyo Japan.

This large-scale crowdsourced study using the iPhone application DryEyeRhythm identified the risk factors for severe dry eye disease-type symptoms, which included female sex, collagen disease, hay fever, depression, current contact-lens use, extended screen time, and smoking. Read More

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December 2018

A review of lifestyle, metabolic risk factors and blood-based biomarkers for early diagnosis of pancreatic ductal adenocarcinoma.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health|, University of Oxford, Oxford, UK.

We aimed to review the epidemiologic literature examining lifestyle, metabolic risk factors, and blood-based biomarkers including multi-omics (genomics, proteomics, and metabolomics) and to discuss how these predictive markers can inform early diagnosis of pancreatic ductal adenocarcinoma (PDAC). A search of the PubMed database was conducted in June 2018 to review epidemiologic studies of (1) lifestyle and metabolic risk factors for PDAC, genome-wide association studies (GWAS), and risk prediction models incorporating these factors and (2) blood-based biomarkers for PDAC (conventional diagnostic markers, metabolomics, and proteomics). Prospective cohort studies have reported at least twenty possible risk factors for PDAC, including smoking, heavy alcohol drinking, adiposity, diabetes, and pancreatitis, but the relative risks (RR) and population attributable fractions of individual risk factors are small (mostly <10%). Read More

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December 2018

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5868-5875

Laboratory of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan.

Purpose: Previous experimental studies assessing corneal nerves as a measure of the severity of diabetic peripheral neuropathy have yielded discordant results; this may have been due to the effect of the short duration of the induced diabetes. We investigated whether increases in the duration of hyperglycemia result in the development of corneal lesions in a mouse model of alloxan (AL)- or streptozotocin (STZ)-induced type 1 diabetes. We further determined whether corneal nerve fiber density, intraepidermal nerve fiber density (IENFD), and sural nerve morphology can be used as morphologic markers of diabetic peripheral neuropathy in rodent models. Read More

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December 2018

Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5965-5972

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States.

Purpose: The purpose of this study was to investigate the effect of reducing diabetes-induced lysyl oxidase (LOX) overexpression on vascular cell apoptosis and blood-retinal barrier (BRB) characteristics in diabetic rats.

Methods: Nondiabetic rats, diabetic rats, and diabetic rats intravitreally (IV) injected with LOX siRNA or scrambled (scram) siRNA were used in the study. One month after the onset of diabetes, intravitreal injections were initiated at monthly intervals for up to three times. Read More

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December 2018

CE: Addressing Food Insecurity in Vulnerable Populations.

Am J Nurs 2018 Dec 12. Epub 2018 Dec 12.

Heather L. Flores is an NP at the John and Ella Byrd McCain Health and Counseling Center, Alabama A&M University, Huntsville. Azita Amiri is an assistant professor of nursing at the University of Alabama, Huntsville. Contact author: Heather L. Flores, The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.

A review of risk factors, health effects, screening, and resources. ABSTRACT: Food insecurity affects people of all ages, in every area in which nurses work or volunteer. The U. Read More

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December 2018

Vitamin K: a nutrient which plays a little-known role in glucose metabolism.

Curr Opin Clin Nutr Metab Care 2018 Dec 12. Epub 2018 Dec 12.

Sorbonne Université, Diabetes Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris.

Purpose Of Review: Type 2 diabetes is one of the most important public health diseases. Type 2 diabetes pathophysiology involves multiple pathways, in which micronutrients could play a role. Among them, interest has grown concerning vitamin K. Read More

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December 2018

The impact of anti-vascular endothelial growth factor agents on visual impairment/blindness prevention in patients with diabetic macular edema and on associated patient and caregiver burden in Japan.

J Med Econ 2018 Dec 14:1-28. Epub 2018 Dec 14.

e Market Access, Health Economics and Outcomes Research , Bayer Yakuhin, Ltd , Tokyo , Japan.

Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan.

Methods: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80. Read More

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December 2018

Impact of dose capping in insulin glargine/lixisenatide fixed-ratio combination trials in patients with type 2 diabetes.

Curr Med Res Opin 2018 Dec 14:1-21. Epub 2018 Dec 14.

d National Research Institute , Los Angeles , CA , USA .

Objective: The LixiLan clinical trials of insulin glargine (iGlar)/lixisenatide fixed-ratio combination (iGlarLixi) investigated the safety and efficacy of iGlarLixi versus iGlar: LixiLan-O (NCT02058147) in patients with type 2 diabetes (T2D) inadequately controlled on oral antidiabetes drugs (OADs), and LixiLan-L (NCT02058160) in patients with T2D inadequately controlled on basal insulin ± OADs. In these two trials, both iGlar and iGlarLixi were titrated to a maximum (capped) dose of 60 units. We evaluated whether this may have affected the reported glycemic efficacy of iGlar, and the glycemic differences observed between treatment with iGlarLixi and iGlar. Read More

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December 2018

Comparison of a twice-daily injection of insulin aspart 50 with insulin aspart 30 in patients with poorly controlled type 2 diabetes.

Curr Med Res Opin 2018 Dec 14:1-16. Epub 2018 Dec 14.

a Department of Endocrinology , The First Affiliated Hospital of Dalian Medical University , Dalian , PR China.

Objective: To compare the efficacy and safety of a twice-daily injection of insulin aspart (BIAsp) 30 and BIAsp50 in patients with type 2 diabetes mellitus (T2DM) poorly controlled with oral hypoglycaemic agents (OHAs).

Methods: In this 12-week prospective, randomized, parallel trial, a total of 80 T2DM patients, 59 ± 10 years old with a disease duration of 9.3 ± 6. Read More

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December 2018

Eating pathology and psychological outcomes in young adults in self-regulation interventions using daily self-weighing.

Health Psychol 2018 Dec 13. Epub 2018 Dec 13.

Warren Alpert Medical School.

Objective: Self-regulation interventions encouraging daily weighing prevent weight gain in young adults; however, concerns have been raised that such interventions may have undesirable effects on eating pathology, depression, and health-related quality of life (HRQL). The present study examined whether self-regulation interventions and self-weighing frequency were associated with these indices in normal weight individuals and those with overweight or obesity.

Methods: Young adults ( = 599), 18-35 years with a body mass index (BMI) 21. Read More

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December 2018

Is it time to remodel diabetes self-management education and support?

Authors:
Hope S Warshaw

Am J Manag Care 2018 Sep;24(11 Spec No.):SP449-SP451

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September 2018

[Position paper on taxes to non-basic energy-dense foods and sugar-sweetened beverages].

Salud Publica Mex 2018 Sep-Oct;60(5):586-591

Dirección General, Instituto Nacional de Salud Pública. México.

In 2014 the Mexican government implemented taxes to reduce the consumption of sugar-sweetened beverages and nonessential energy-dense foods. In this manuscript, we analyze the scientific evidence linking the consumption of these products to chronic diseases, and summarize the studies that have evaluated the observed and expected impact of food taxes in Mexico. The implementation of taxes to unhealthy foods has reduced purchases of sugar-sweetened beverages in 7. Read More

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[Development and validation of a screening score for prediabetes and undiagnosed diabetes.]

Salud Publica Mex 2018 Sep-Oct;60(5):500-509

Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Ciudad de México, México.

Objective: To develop and validate an easy-to-use risk score to detect prediabetes and undiagnosed diabetes in Mexican population.

Materials And Methods: Using information from the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán's cohort study of 10 234 adults, risk factors were identified and included in multiple logistic regression models stratified by sex. The beta coefficients of the final model were multiplied by 10, thus obtaining the weights of each variable in the score. Read More

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BDNF Val66Met is Associated with Pre-existing but not with Paclitaxel-induced Peripheral Neuropathy in an Israeli Cohort of Breast Cancer Patients.

Isr Med Assoc J 2018 Dec;20(12):746-748

Department of Hematology, Galilee Medical Center, Nahariya, Israel, affiliated with Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.

Background: Brain-derived neurotrophic factor (BDNF) is a neuronal growth factor that is important for the development, maintenance, and repair of the peripheral nervous system. The BDNF gene commonly carries a single nucleotide polymorphism (Val66Met-SNP), which affects the cellular distribution and activity-dependent secretion of BDNF in neuronal cells.

Objectives: To check the association between BDNF Val66Met-SNP as a predisposition that enhances the development of chemotherapy-induced peripheral neuropathy in an Israeli cohort of patients with breast cancer who were treated with paclitaxel. Read More

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December 2018

Mean Platelet Volume in Patients with Acute Ischemic Stroke with Nonvalvular Atrial Fibrillation.

Clin Lab 2018 Oct;64(11)

Background: Platelets play an important role in the pathogenesis of vascular disease, and the size of the platelets can determine their reactivity. Large platelets secrete more prothrombotic factors and aggregate more quickly. In this study, we aimed to investigate mean platelet volume (MPV) levels, which are considered to be an indication of the increase in platelet function in previous studies, in cases of acute ischemic stroke (AIS) with nonvalvular atrial fibrillation (NVAF). Read More

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October 2018

Diabetes-free survival after extended distal pancreatectomy and islet auto transplantation for benign or borderline/malignant lesions of the pancreas.

Am J Transplant 2018 Dec 14. Epub 2018 Dec 14.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Islet autotransplantation is particularly attractive to prevent diabetes after extended pancreatectomy for benign or borderline/malignant pancreas disease. Between 2008 and 2018, 25 patients underwent left extended pancreatectomy (>60%) and islet autotransplantation for neoplasm located in the pancreatic neck or proximal body. Overall, disease-free and diabetes-free survivals were estimated and compared with those observed in 68 non diabetic patients who underwent distal pancreatectomy for pancreatic neoplasms without islet autotransplantation. Read More

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December 2018

Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals.

Diabetes Metab Res Rev 2018 Dec 14:e3117. Epub 2018 Dec 14.

Department of Endocrinology, Huashan Hospital Fudan University.

Objective: Cathepsin S is highly expressed in subcutaneous and visceral adipose tissue. Cathepsin S correlates with central obesity and contributes to the formation and progression of atherosclerosis. Here, we sought to evaluate the association of serum cathepsin S with metabolic syndrome (MS) in overweight and obese Chinese adults. Read More

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December 2018

Entecavir and peginterferon alfa-2a in adults with HBeAg-positive immune tolerant chronic hepatitis B virus infection.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

University of Michigan.

Background/aim: Monotherapy with interferon or nucleoside analog is generally not recommended during the immune tolerant (IT) phase of chronic hepatitis B virus (HBV) infection. Recognition that high HBV DNA levels are associated with hepatocellular carcinoma has increased interest in treating HBV in the IT phase. Small pediatric studies reported efficacy with combination nucleoside analog and interferon therapy. Read More

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December 2018

FDG-PET/CT for diagnosis and follow-up of necrotizing (malignant) external otitis.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Petach Tikva, Israel.

Objective: Imaging is important for the diagnosis and follow-up of necrotizing external otitis (NEO). The best imaging modality is controversy. To suggest 2-deoxy-2-[fluorine-18] fluoro-D-glucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) as an alternative to technetium-99m and gallium-67 scans for diagnosis and assessment of response to treatment for patients with NEO. Read More

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December 2018

Dysfunctional endothelial progenitor cells in patients with Hodgkin's lymphoma in complete remission.

Cancer Med 2018 Dec 13. Epub 2018 Dec 13.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Patients with a history of Hodgkin's lymphoma (HL) are at increased long-term risk of cardiovascular morbidity and mortality. Studies report an association between the pathophysiology of coronary artery disease (CAD) and levels of circulating endothelial progenitor cells (EPC), which play an essential role in vascular injury repair. The aim of the present study was to investigate the potential involvement of abnormal EPC level or function in the CAD risk of survivors of HL in remission. Read More

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December 2018

The -44 C/G (rs1800972) polymorphism of the β-defensin 1 is associated with increased risk of developing type 2 diabetes mellitus.

Mol Genet Genomic Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Background: The aim of this study was to establish the association of two polymorphisms of the β-defensin 1 gene (DEFB1, OMIM#602056) with the risk of developing type 2 diabetes mellitus (T2DM) in a group of Mexican patients.

Methods: The 5'UTR -20 G/A, and -44 C/G polymorphisms of DEFB1 gene were genotyped by 5' exonuclease TaqMan assays in a group of 252 patients with T2DM and 522 healthy control.

Results: Under dominant and additive models adjusted for the risk factors, the C allele of the -44 C/G polymorphism was associated with increased risk of T2DM (OR = 1. Read More

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December 2018

Integrating a genome-wide association study with a large-scale transcriptome analysis to predict genetic regions influencing the glycaemic index and texture in rice.

Plant Biotechnol J 2018 Dec 13. Epub 2018 Dec 13.

International Rice Research Institute, Los Baños, Laguna, 4030, Philippines.

Reliably generating rice varieties with low glycaemic index (GI) is an important nutritional intervention given the high rates of Type II diabetes incidences in Asia where rice is staple diet. We integrated a genome-wide association study (GWAS) with a transcriptome-wide association study (TWAS) to determine the genetic basis of the GI in rice. GWAS utilized 305 re-sequenced diverse indica panel comprising ~2. Read More

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December 2018

Left ventricular reverse remodelling predicts long-term outcomes in patients with functional mitral regurgitation undergoing MitraClip therapy: results from a multicentre registry.

Eur J Heart Fail 2018 Dec 13. Epub 2018 Dec 13.

Civil Hospital and University of Brescia, Brescia, Italy.

Aims: To explore whether left ventricular reverse remodelling (LVRR) is a predictor of outcomes in patients with functional mitral regurgitation (FMR) undergoing MitraClip procedure.

Methods And Results: We analysed 184 consecutive patients with FMR who underwent successful MitraClip procedure. LVRR was defined as a reduction in left ventricular end-systolic volume ≥ 10% from baseline to 6 months. Read More

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December 2018

Multiple psychological factors predict abdominal pain severity in children with irritable bowel syndrome.

Neurogastroenterol Motil 2018 Dec 13:e13509. Epub 2018 Dec 13.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background: Anxiety and depression are implicated as contributors to abdominal pain in pediatric irritable bowel syndrome (IBS) but is unclear if this pain is associated with other psychological factors. The study objective was to test if the impact of anxiety or depression on IBS symptom severity is mediated by somatization and/or pain catastrophizing.

Methods: We utilized baseline data from local pediatric IBS clinical studies. Read More

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December 2018

The diabetic phenotype is preserved in myotubes established from type 2 diabetic subjects: a critical appraisal.

Authors:
Michael Gaster

APMIS 2019 Jan;127(1):3-26

Laboratory for Molecular Physiology, Department of Pathology and Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Cultured human myotubes offer a unique model to distinguish between primary and environmental factors in the aetiology of insulin resistance in human skeletal muscle. The objective of this review was to summarize our and other group studies on insulin resistance in human myotubes established from lean, obese and type 2 diabetes (T2D) subjects. Overall, studies of human myotubes established from lean, obese and T2D subjects clearly show that part of the diabetic phenotype observed in vivo is preserved in diabetic myotubes. Read More

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January 2019

Insights into the Pulmonary Vascular complications of heart failure with Preserved Ejection Fraction.

J Physiol 2018 Dec 13. Epub 2018 Dec 13.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Pulmonary hypertension in the setting of heart failure with preserved ejection fraction (PH-HFpEF) is a growing public health problem that is increasing in prevalence. While PH-HFpEF is defined by a high mean pulmonary artery pressure, high left ventricular end-diastolic pressure and a normal ejection fraction, some HFpEF patients develop PH in the presence of pulmonary vascular remodeling with a high transpulmonary pressure gradient or pulmonary vascular resistance. Aging, increased left atrial pressure and stiffness, mitral regurgitation, as well as features of metabolic syndrome, which include obesity, diabetes, and hypertension, are recognized as risk factors for PH-HFpEF. Read More

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December 2018

LncRNA NEAT1 promotes extracellular matrix accumulation and epithelial-to-mesenchymal transition by targeting miR-27b-3p and ZEB1 in diabetic nephropathy.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.

Diabetic nephropathy (DN) is a kind of microvascular complications of diabetes. Long noncoding RNAs (lnRNAs) can participate in the development of various diseases, including DN. However, the function of lncRNA NEAT1 is unclear. Read More

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December 2018

Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus.

Compr Physiol 2018 Dec 13;9(1):1-58. Epub 2018 Dec 13.

Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

The objective of this comprehensive review is to summarize and discuss the available evidence of how adipose tissue inflammation affects insulin sensitivity and glucose tolerance. Low-grade, chronic adipose tissue inflammation is characterized by infiltration of macrophages and other immune cell populations into adipose tissue, and a shift toward more proinflammatory subtypes of leukocytes. The infiltration of proinflammatory cells in adipose tissue is associated with an increased production of key chemokines such as C-C motif chemokine ligand 2, proinflammatory cytokines including tumor necrosis factor α and interleukins 1β and 6 as well as reduced expression of the key insulin-sensitizing adipokine, adiponectin. Read More

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December 2018

Peripheral fat distribution versus waist circumference in metabolic syndrome for predicting mortality.

Diabetes Metab Res Rev 2018 Dec 13:e3116. Epub 2018 Dec 13.

Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Objective To elucidate whether the PF-combined definition of metabolic syndrome (MetS) would show a better predictive ability for cause-specific mortality than the common MetS. Methods The data were derived from the National Health and Nutrition Examination Survey from 1999 through 2002. We investigated three types of MetS including WCMetS, PFMetS, and PF-combined definition MetS. Read More

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December 2018

Lactation intensity and duration to postpartum diabetes and prediabetes in women with gestational diabetes.

Diabetes Metab Res Rev 2018 Dec 13:e3115. Epub 2018 Dec 13.

Pennington Biomedical Research Center, Baton Rouge, LA.

Objective: To investigate the association of lactation intensity and duration with postpartum diabetes and prediabetes risks among Chinese women with a history of GDM.

Methods: We included 1260 women with a history of GDM who participated in the whole populationꞋs GDM universal screening survey by using World Health OrganizationꞋs criteria. Lactation intensity and lactation duration were collected by a standardized questionnaire. Read More

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December 2018

Adipokines and macrophage markers during pregnancy -possible role for sCD163 in prediction and progression of gestational diabetes mellitus.

Diabetes Metab Res Rev 2018 Dec 13:e3114. Epub 2018 Dec 13.

Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Aims: The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection of these markers improved prediction of GDM and if they remained modified during long-term follow-up. Read More

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December 2018

Applicability of telemedicine in the screening of diabetic retinopathy (DR): The first multicentre study in Italy. The No Blind Study.

Diabetes Metab Res Rev 2018 Dec 13:e3113. Epub 2018 Dec 13.

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Aims: Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening program many patients who otherwise would be excluded.

Materials And Methods: The NO Blind is a transversal, multicentre, observational study. Read More

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December 2018

The effect of diabetes on tooth loss due to periodontal disease: A nationwide population-based cohort study in south korea.

J Periodontol 2018 Dec 13. Epub 2018 Dec 13.

Department of Prosthodontics, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang-si, , Gyeonggi-do, 10444, Republic of Korea.

Background: Our purpose was to compare the risk of tooth loss due to periodontal disease between diabetic and non-diabetic individuals and to estimate the relative risk of tooth loss according to the severity and control of diabetes.

Methods: We selected 10,215 individuals who diagnosed as diabetes in the Korean National Health Insurance Service - National Sample Cohort (NHIS-NSC) database in 2003 and the same number of individuals who had never been diagnosed with diabetes during the period covered by the NHIS-NSC (2002-2013) with propensity score matching. Diabetic individuals were divided into two groups according to the treatment modality. Read More

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December 2018

Cross-talk of healthy and impaired human tissues for dissection of disease pathogenesis.

Biotechnol Prog 2018 Dec 13:e2766. Epub 2018 Dec 13.

Venetian Institute of Molecular Medicine, Via Orus 2, 35131, Padova, Italy.

Systemic diseases affect multiple tissues that interact with each other within a network difficult to explore at the body level. However, understanding the inter-dependences between tissues could be of high relevance for drug target identification, especially at the first stages of disease development. In vitro systems have the advantages of accessibility to measurements and precise controllability of culture conditions, but currently have limitations in mimicking human in vivo systemic tissue response. Read More

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December 2018

Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men.

Mol Nutr Food Res 2018 Dec 12:e1800605. Epub 2018 Dec 12.

S. Noerman, Dr. O. Kärkkäinen, Prof. T. Nurmi, Prof. T.-P. Tuomainen, Prof. S. Voutilainen, Dr. K. Hanhineva, Dr. J. K. Virtanen, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Scope: Higher egg intake was previously associated with a lower risk of developing type 2 diabetes (T2D) in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in eastern Finland. We explored potential compounds that could explain this association using non-targeted LC-MS-based metabolic profiling.

Methods And Results: We analyzed 239 baseline serum samples from the KIHD in 4 groups: subjects with higher (mean intake 1 egg/d) or lower (mean intake 2 eggs/wk) egg intake who developed T2D (cases) or remained heatlhy (controls) during the mean follow-up of 19. Read More

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December 2018

Weight control before and during pregnancy for patients with gestational diabetes mellitus.

J Diabetes Investig 2018 Dec 12. Epub 2018 Dec 12.

Department of Endocrinology and Diabetes, Saitama Medical University, Iruma-gun, Saitama, 350-0495, Japan.

Aims/introduction: To examine the associations of pregestational body mass index (BMI) and gestational weight change with birthweight for gestational age in Japanese mothers with gestational diabetes mellitus (GDM).

Materials And Methods: We retrospectively examined the clinical and laboratory characteristics of 101 mothers with GDM (pregestational BMI, mean ± SD: 24.7 ± 5. Read More

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December 2018

Cutaneous mucormycosis.

Transpl Infect Dis 2018 Dec 13:e13039. Epub 2018 Dec 13.

Department of Hematology, AZ Delta Roeselare.

Mucormycosis is an aggressive invasive fungal infection that occurs rarely in immunocompetent but frequently in immunocompromised patients. We present a case of a 68-year old patient with cutaneous mucormycosis due to Rhizopus pusillus. He was initially hospitalized for invasive pulmonary aspergillosis and diabetes mellitus secondary to acute graft-versus-host treatment with glucocorticoids after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia. Read More

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December 2018

Predicting Infections in Chronic Leg Ulcers: A Step Ahead.

Int J Clin Pract 2018 Dec 12:e13304. Epub 2018 Dec 12.

New York University School of Medicine, Department of Biochemistry and Molecular Pharmacology.

Chronic wounds, often called ulcers, are a worldwide challenge and were recently referred to as a silent epidemic [1-4]. They have been classified into vascular, diabetic, and pressure ulcers, have a significant impact on the individual, the healthcare system, and society as a whole [5-7], and affect virtually all aspects of life [8, 9]. The medical and socioeconomic impact of chronic ulcers is escalating worldwide, a trend at least partly driven by escalating health care costs, an aging population, an increase in the incidence of diabetes, and the obesity pandemic [1, 10, 11]. Read More

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December 2018

Knockdown of FOXO6 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Oxidative stress and apoptosis in retinal pigment epithelium cells are involved in the pathogenesis of diabetic retinopathy (DR). Forkhead box class O 6 (FOXO6) is a member of the FOXO family that can regulate diabetes-induced oxidative stress. However, the role of FOXO6 in DR has not been clarified. Read More

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December 2018

Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes.

Liver Int 2018 Dec 12. Epub 2018 Dec 12.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

I would like to congratulate Morrison and colleagues for the interesting meta-analysis aimed at investigating the association between non-alcoholic fatty liver disease (NAFLD) and the risk of incident cardiovascular disease (CVD) or type 2 diabetes mellitus (T2DM). In this elegant meta-analysis, the Authors demonstrated that NAFLD was not independently associated with an increased risk of incident CVD (n=13 eligible studies, RR 1.48, 95% CI 0. Read More

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December 2018

Brown adipose tissue thermogenesis in polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

Department of Physiology, Monash University, Melbourne, Victoria, Australia.

Objective: Polycystic ovary syndrome (PCOS) is associated with increased obesity with a greater propensity to weight gain and a lack of sustainable lifestyle interventions. Altered brown adipose tissue (BAT) thermogenesis is a potential contributor to obesity in PCOS. BAT activity and modulation has not been studied in PCOS. Read More

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December 2018
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