21,406 results match your criteria Diabetes Technology & Therapeutics[Journal]


Anti-α-Glucosidase Activity by a Protease from .

Molecules 2019 Feb 15;24(4). Epub 2019 Feb 15.

Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan.

Anti-α-glucosidase (AAG) compounds have received great attention due to their potential use in treating diabetes. In this study, TKU004, an isolated bacterial strain from Taiwanese soil, produced AAG activity in the culture supernatant when squid pens were used as the sole carbon/nitrogen (C/N) source. The protein TKU004P, which was isolated from TKU004, showed stronger AAG activity than acarbose, a commercial anti-diabetic drug (IC = 0. Read More

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http://dx.doi.org/10.3390/molecules24040691DOI Listing
February 2019

Dietary Patterns during Pregnancy Are Associated with the Risk of Gestational Diabetes Mellitus: Evidence from a Chinese Prospective Birth Cohort Study.

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

Department of Social Medicine, School of Public Health, China Medical University, Shenyang 110122, China.

Dietary patterns during pregnancy have been shown to influence the development of gestational diabetes mellitus (GDM). However, evidence from Asian populations is limited and inconsistent. We conducted a prospective cohort study in China to assess the relationship between dietary patterns and GDM. Read More

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http://dx.doi.org/10.3390/nu11020405DOI Listing
February 2019

Novel Ran-RCC1 Inhibitory Peptide-Loaded Nanoparticles Have Anti-Cancer Efficacy In Vitro and In Vivo.

Cancers (Basel) 2019 Feb 14;11(2). Epub 2019 Feb 14.

Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK.

The delivery of anticancer agents to their subcellular sites of action is a significant challenge for effective cancer therapy. Peptides, which are integral to several oncogenic pathways, have significant potential to be utilised as cancer therapeutics due to their selectivity, high potency and lack of normal cell toxicity. Novel Ras protein-Regulator of chromosome condensation 1 (Ran-RCC1) inhibitory peptides designed to interact with Ran, a novel therapeutic target in breast cancer, were delivered by entrapment into polyethylene glycol-poly (lactic-co-glycolic acid) PEG-PLGA polymeric nanoparticles (NPs). Read More

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http://dx.doi.org/10.3390/cancers11020222DOI Listing
February 2019

Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India. Electronic address:

Aims: Renin-angiotensin system (RAS) and natriuretic peptides system (NPS) perturbations govern the development of diabetic nephropathy (DN). Hence, in search of a novel therapy against DN, present study targeted both, NPS and RAS simultaneously using a neprilysin inhibitor (NEPi) in combination with either angiotensin receptor blocker (ARB) or angiotensin-converting enzyme 2 (ACE2) activator.

Methods: We induced diabetes in male Wistar rats by a single dose of streptozotocin (55 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.027DOI Listing
February 2019

Recent Development on Anti-Obesity Compounds and Their Mechanisms of Action: A Review.

Curr Med Chem 2019 Feb 14. Epub 2019 Feb 14.

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Drug Research Institute, School of Pharmacy, Hunan University of Chinese Medicine,Changsha, 410208. China.

Obesity, associated with a series of complications such as diabetes, hypertension, and heart disease, is a great threat to human health and leads to increased morbidity and mortality. In spite of the presence of anti-obesity agents on the market, the application of these drugs is limited because of their typical side effects. More effective and safe weight-loss drugs are being pursued by many researchers, correspondingly, growing small molecules and natural products with anti-obesity effects have been identified and the molecular mechanisms underlying the action of novel and known compounds have at least partially been revealed. Read More

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http://dx.doi.org/10.2174/0929867326666190215114359DOI Listing
February 2019

Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial.

Obesity (Silver Spring) 2019 Feb 14. Epub 2019 Feb 14.

Center for Nutrition Research, Institution for Food Safety and Health, Illinois Institute of Technology, Chicago, Illinois, USA.

Objective: This study investigated the effect of red raspberry intake on meal-induced postprandial metabolic responses in individuals who have overweight or obesity with prediabetes and insulin resistance (PreDM-IR), and in metabolically healthy individuals (Reference).

Methods: Thirty-two adults (PreDM-IR, n = 21; Reference, n = 11) were randomized to a controlled, three-arm, single-blinded, crossover trial. Participants were provided 0 g of frozen red raspberries (Control), 125 g of frozen red raspberries (RR-125) (~1 cup), or 250 g of frozen red raspberries (RR-250) (~2 cups), with a challenge breakfast meal (high carbohydrate/moderate fat) on three separate days. Read More

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http://doi.wiley.com/10.1002/oby.22406
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http://dx.doi.org/10.1002/oby.22406DOI Listing
February 2019
2 Reads

Antidiabetic properties of aqueous and methanol extracts from the trunk bark of Ceiba pentandra in type 2 diabetic rat.

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon.

The type 2 diabetes is one of the major global health issues that affects millions of people. This study evaluated the antidiabetic activity of aqueous extracts (AECP) and methanol extracts (MECP) from Ceiba pentandra trunk bark on an experimental model of type 2 diabetes (T2D). This model was induced in rats by the combination of a high-fat diet (HFD) and a single dose of streptozotocin (40 mg/kg, intraperitoneal) at the seventh day of experimentation. Read More

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http://dx.doi.org/10.1002/jcb.28437DOI Listing
February 2019
3.263 Impact Factor

Genetic risk score combining six genetic variants associated with the cellular NRF2 expression levels correlates with Type 2 diabetes in the human population.

Genes Genomics 2019 Feb 14. Epub 2019 Feb 14.

Department of Biomedical Science, Hallym University, Chuncheon, 200-702, Gangwon-do, Republic of Korea.

Background: Type 2 diabetes (T2D) is known as an inflammatory disease. NRF2 (Nuclear Factor Erythroid 2 Like2) encodes a transcription factor that binds to antioxidant response elements (AREs) and regulates the expression of genes involved in many antioxidant responses.

Objective: This study aimed to gain insight into individual anti-inflammatory activity to prevent T2D development in humans. Read More

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http://dx.doi.org/10.1007/s13258-019-00791-0DOI Listing
February 2019

Mechanisms of age and race differences in receiving minimally invasive inguinal hernia repair.

Surg Endosc 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, University of Michigan, 2800 Plymouth Road, Building 16, 1st Floor, Ann Arbor, MI, 48109, USA.

Background: Black patients and older adults are less likely to receive minimally invasive hernia repair. These differences by race and age may be influenced by surgeon-specific utilization rate of minimally invasive repair. In this study, we explored the association between race, age, and surgeon utilization of minimally invasive surgery (MIS) with the likelihood of receiving MIS inguinal hernia repair. Read More

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http://dx.doi.org/10.1007/s00464-019-06695-0DOI Listing
February 2019

Hyperglycaemia cause vascular inflammation through advanced glycation end products/early growth response-1 axis in gestational diabetes mellitus.

Mol Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, Tamil Nadu, India.

Hyperglycaemia during pregnancy is the main reason for developing diabetes mediated vascular complications. Advanced glycation end products (AGEs) are formed due to non-enzymatic glycation of proteins, lipids and nucleic acids during hyperglycaemia. It has the potential to damage vasculature by modifying the substrate or by means of AGEs and receptor of AGE (RAGE) interaction. Read More

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http://dx.doi.org/10.1007/s11010-019-03503-0DOI Listing
February 2019

Prevalence and knowledge of hypertension among people living in rural communities in Ghana: a mixed method study.

Afr Health Sci 2018 Dec;18(4):931-941

School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: Knowledge and understanding of hypertension and its associated health risks remain inadequate despite increasing trend of hypertension prevalence. This study was conducted to assess the prevalence, knowledge and perceptions of hypertension in rural communities in Ghana.

Methods: A mixed method study involving 534 subjects was employed. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354880PMC
December 2018

Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria.

Afr Health Sci 2018 Dec;18(4):900-908

Department of Biochemistry, School of Sciences, The Federal University of Technology, P.M.B. 704, Akure, Nigeria.

Background: Type 2 Diabetes Mellitus (T2DM) is associated with diabetic nephropathy and hyperlipidemia. Gender, age, medication adherence, lifestyle, culture and socioeconomic status could be sources of diversity in T2DM leading to differences in predisposition, development and clinical presentation.

Objectives: Therefore, this study aimed to investigate the influence of gender, age and treatment duration on kidney and lipid-related biochemical indices of T2DM patients attending Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria (EKSUTH). Read More

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http://dx.doi.org/10.4314/ahs.v18i4.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354870PMC
December 2018

Impact of weight reduction on insulin resistance, adhesive molecules and adipokines dysregulation among obese type 2 diabetic patients.

Afr Health Sci 2018 Dec;18(4):873-883

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

Background: Type 2 diabetes mellitus is usually related to vascular problems and is associated with impairment in endothelial function characterized by impaired endothelial-dependent vasodilation and increased platelet adhesion. There is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of endothelial dysfunction and adipokines dysregulation for obesity associated with type 2 diabetes mellitus.

Objective: This study was designed to detect the effects of weight loss on insulin resistance, adhesive molecules and adipokines dysregulation in obese type 2 diabetic patients. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354881PMC
December 2018

HMGA1 variant IVS5-13insC is associated with insulin resistance and type 2 diabetes: an updated meta-analysis.

Afr Health Sci 2018 Dec;18(4):865-872

Sports Science Research Center of Shandong Province, Jinan, 250102, China.

Background: High-mobility group A1 (HMGA1) polymorphism has been suspected as a gene variant associated with type 2 diabetes (T2D). However, conflicting outcomes have been reported.

Objective: This meta-analysis aimed to predict the association between the HMGA1 variant IVS5-13insC and T2D. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354845PMC
December 2018

Audit of insulin prescription patterns and associated burden among diabetics in a tertiary health institution in Nigeria.

Afr Health Sci 2018 Dec;18(4):852-864

Department of Medicine, BOWEN University & BOWEN University Teaching Hospital, Ogbomoso.

Background: Insulin is one of the most important anti-diabetic agents in the management of diabetes even among type 2 diabetic.

Objective: There was need to assess insulin adherence, mode of insulin delivery and burden of insulin usage among diabetics.

Methods: A cross-sectional, prospective questionnaire, orally administered at a Diabetes Clinic of a University Teaching Hospital, SouthWest, Nigeria. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354893PMC
December 2018

Lf nanodispersion is a hypoglycemic product with a potent α-glucosidase and pancreatic lipase inhibitor effect.

Saudi Pharm J 2019 Feb 17;27(2):191-199. Epub 2018 Oct 17.

Pharmacy Department, Faculty of Natural Sciences, University of Oriente, Patricio Lumumba s/n, Santiago de Cuba, CP 84500 Santiago de Cuba, Cuba.

Purpose: This study aimed to evaluate the hypoglycemic effect, antioxidant, α-glucosidase and lipase inhibitory activity, and the cytotoxicity of the nanodispersion (CgND).

Methods: The hypoglycemic effect was evaluated in alloxan-induced diabetic mice. The particle size, polydispersion index, ζ-potential, and conductivity, as well as the drug-loaded content, were monitored in shelf-live, along a year. Read More

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http://dx.doi.org/10.1016/j.jsps.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362179PMC
February 2019

Novel Approach to the Treatment of Diabetes: Embryonic Stem Cell and Insulin-Loaded Liposomes and Nanocochleates.

J Nanosci Nanotechnol 2019 Jul;19(7):3706-3719

Department of Pathology, 19 Mayıs University Faculty of Veterinary Medicine, 55220 Samsun, Turkey.

This study aims to investigate and compare the effects of insulin and embryonic stem-cell (ESC) loaded liposomes (LPs) and nanocochleate formulations and their PEGylated forms on the glucose levels. All formulations were characterized considering particle size, zeta potential, polydispersity index and encapsulation efficiencies. insulin that releases from the formulations was determined using Franz-type diffusion cells. Read More

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http://dx.doi.org/10.1166/jnn.2019.16321DOI Listing

Stigma in health facilities: why it matters and how we can change it.

BMC Med 2019 Feb 15;17(1):25. Epub 2019 Feb 15.

Centre for Longitudinal & Life Course Studies, University of Antwerp, Sint-Jacobstraat 2, B-2000, Antwerp, Belgium.

Stigma in health facilities undermines diagnosis, treatment, and successful health outcomes. Addressing stigma is fundamental to delivering quality healthcare and achieving optimal health. This correspondence article seeks to assess how developments over the past 5 years have contributed to the state of programmatic knowledge-both approaches and methods-regarding interventions to reduce stigma in health facilities, and explores the potential to concurrently address multiple health condition stigmas. Read More

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http://dx.doi.org/10.1186/s12916-019-1256-2DOI Listing
February 2019

The association of metabolic syndrome components and diabetes mellitus: evidence from China National Stroke Screening and Prevention Project.

BMC Public Health 2019 Feb 14;19(1):192. Epub 2019 Feb 14.

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China.

Background: The metabolic syndrome (MetS) is related with cardiovascular disease. However, its relationship with diabetes mellitus (DM) has not been examined in Chinese population with a larger sample. We aimed to assess the relationship between metabolic syndrome (MetS) and its components, and DM, and to determine the best one from the available definitions of Mets when assessing the risk of DM. Read More

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http://dx.doi.org/10.1186/s12889-019-6415-zDOI Listing
February 2019

Proportional subcellular localization of Arabidopsis thaliana RabA1a.

Plant Signal Behav 2019 Feb 14:1-4. Epub 2019 Feb 14.

e Department of Biology Education , Kyungpook National University , Daegu , South Korea.

Subcellular localization of trafficking proteins in a single cell affects the assembly of trafficking machinery between organelles and vesicles throughout the targeting pathway. RabGTPase is one of the regulators to direct specific targeting of cargo molecules depending on GDP/GTP bound status. We have recently determined the crystal structures of GDP-bound inactive and both GTP- and GppNHp-bound active forms of Arabidopsis RabA1a. Read More

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http://dx.doi.org/10.1080/15592324.2019.1581561DOI Listing
February 2019

Autism Spectrum Disorder (ASD) with and without Mental Regression is Associated with Changes in the Fecal Microbiota.

Nutrients 2019 Feb 5;11(2). Epub 2019 Feb 5.

Pediatric Research and Metabolism Unit, Reina Sofia University Hospital, Maimónides Institute forBiomedical Research of Córdoba (IMIBIC), University of Córdoba, 14010 Córdoba, Spain.

New microbiome sequencing technologies provide novel information about the potential interactions among intestinal microorganisms and the host in some neuropathologies as autism spectrum disorders (ASD). The microbiota⁻gut⁻brain axis is an emerging aspect in the generation of autistic behaviors; evidence from animal models suggests that intestinal microbial shifts may produce changes fitting the clinical picture of autism. The aim of the present study was to evaluate the fecal metagenomic profiles in children with ASD and compare them with healthy participants. Read More

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http://dx.doi.org/10.3390/nu11020337DOI Listing
February 2019

[Specialized food products with modified carbohydrate profile for dietary correction of diet of patients with type 2 diabetes].

Vopr Pitan 2018 13;87(6):76-88. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In recent years, the incidence of diabetes mellitus (DM) in the world is growing steadily. According to the international diabetes Federation (IDF), the number of DM patients in the world in 2015 was 415 million, of them more than 90% - patients with type 2 diabetes. According to forecasts, in 2040 their number will increase to 642 million. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10069DOI Listing
November 2018

A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes.

Mol Nutr Food Res 2019 Feb 14:e1800967. Epub 2019 Feb 14.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Introduction: Few data exist examining the effects of whole grain (WG) versus refined grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and β-cell function.

Methods: In a double-blind crossover randomized controlled trial, 13 sedentary prediabetic adults (37.2±1. Read More

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http://dx.doi.org/10.1002/mnfr.201800967DOI Listing
February 2019

Is type of depressive symptoms associated with patient-perceived need for professional psychological care in depressed individuals with diabetes?

PLoS One 2019 14;14(2):e0212304. Epub 2019 Feb 14.

Department of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Aims: The objective of this study is to investigate whether type of depressive symptoms (i.e. cognitive-affective or somatic) is related to a patient-perceived need for professional psychological care in individuals with diabetes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212304PLOS
February 2019

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm.

Circ Res 2019 Feb;124(4):619-630

From the Wallace H. Coulter Department of Biomedical Engineering, Emory University, Georgia Institute of Technology, Atlanta (S.K., H.J.).

Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall and is among the most challenging cardiovascular diseases as without urgent surgical intervention, ruptured AAA has a mortality rate of >80%. Most patients present acutely after aneurysm rupture or dissection from a previously asymptomatic condition and are managed by either surgery or endovascular repair. Patients usually are old and have other concurrent diseases and conditions, such as diabetes mellitus, obesity, and hypercholesterolemia making surgical intervention more difficult. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31243
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http://dx.doi.org/10.1161/CIRCRESAHA.118.312438DOI Listing
February 2019
1 Read

Characteristics of CF-related Diabetes: Data from Two Different Sources the ECFS Patient Registry and the DPV Registry.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, 89081 Ulm, Germany.

Background: Standardized patient registries provide a unique basis to get insight into cystic fibrosis-related diabetes (CFRD), the most common comorbidity in cystic fibrosis.

Methods: 3,853 CFRD patients from the European CF Society Patient Registry (ECFSPR) and 752 from the German/Austrian diabetes prospective follow-up (DPV) were studied. To adjust for age and sex, multivariable regression was used (SAS 9. Read More

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http://dx.doi.org/10.1111/pedi.12831DOI Listing
February 2019

Assessing patient-reported outcomes for automated insulin delivery systems: the psychometric properties of the INSPIRE measures.

Diabet Med 2019 Feb 14. Epub 2019 Feb 14.

Bournemouth University, Bournemouth, UK.

Aim: Participants in clinical trials assessing automated insulin delivery systems report perceived benefits and burdens that reflect their experiences and may predict their likelihood of uptake and continued use of this novel technology. Despite the importance of understanding their perspectives, there are no available validated and reliable measures assessing the psychosocial aspects of automated insulin delivery systems. The present study assesses the initial psychometric properties of the INSPIRE measures, which were developed for youth and adults with Type 1 diabetes, as well as parents and partners. Read More

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http://dx.doi.org/10.1111/dme.13930DOI Listing
February 2019

IL-33 at the Crossroads of Metabolic Disorders and Immunity.

Authors:
Lei Tu Lijing Yang

Front Endocrinol (Lausanne) 2019 30;10:26. Epub 2019 Jan 30.

Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China.

As a cytokine in interleukin-1(IL-1) family, interleukin-33(IL-33) usually exists in the cytoplasm and cell nucleus. When the cells are activated or damaged, IL-33 can be secreted into extracellular and regulate the functions of various immune cells through binding to its specific receptor suppression of tumorigenicity 2 (ST2). Except regulating the function of immune cells including T cells, B cells, dendritic cells (DCs), macrophages, mast cells, and innate lymphoid cells, IL-33 also plays an important role in metabolic diseases and has received an increasing attention. Read More

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https://www.frontiersin.org/article/10.3389/fendo.2019.00026
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http://dx.doi.org/10.3389/fendo.2019.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363685PMC
January 2019
1 Read

Migraine and increased risk of developing open angle glaucoma: a population-based cohort study.

BMC Ophthalmol 2019 Feb 13;19(1):50. Epub 2019 Feb 13.

Department of Ophthalmology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.

Background: Migraine is linked to endothelial dysfunction and is considered to be a systemic vasculopathy. Interestingly, systemic vascular diseases also occur in glaucoma patients and are considered to be vascular risk factors. Whether migraine is simply a concomitant condition in glaucoma patients or a risk factor per se for glaucoma remains unknown. Read More

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http://dx.doi.org/10.1186/s12886-019-1062-9DOI Listing
February 2019

Maternal hepatitis B surface antigen carrier status increased the incidence of gestational diabetes mellitus.

BMC Infect Dis 2019 Feb 13;19(1):147. Epub 2019 Feb 13.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13th Hangkong Road, Wuhan, 430030, Hubei, China.

Background: The relationship between chronic hepatitis B virus (HBV) infection with gestational diabetes mellitus (GDM) remains unclear. This study aimed to identify the association between maternal HBsAg-positive status and GDM.

Methods: A retrospective cohort study was performed on the pregnant women who delivered from June 2012 to May 2016 at Wuhan Medical Care Center for Women and Children, Wuhan, China. Read More

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http://dx.doi.org/10.1186/s12879-019-3749-1DOI Listing
February 2019

Oxidative stress and small, dense low-density lipoproteins: current and future perspectives.

Expert Rev Endocrinol Metab 2012 Jul;7(4):415-417

a Division of Endocrinology, Diabetes and Metabolism, University of South Carolina School of Medicine, Columbia, SC, USA.

Small, dense low-density lipoproteins (LDLs) are more susceptible to oxidation than their larger, more buoyant counterparts and therefore the biological modification of these LDL particles may, in part, be responsible for their atherogenic properties. Kotani et al. found that at multiple regression analysis there was an independent and significant inverse correlation between the mean LDL particle size and the oxidative stress status; notably, the authors adjusted not only for the traditional cardiovascular risk factors, but also for drug treatments. Read More

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http://dx.doi.org/10.1586/eem.12.30DOI Listing

Fasting serum glucose, thyroid-stimulating hormone, and thyroid hormones and risk of papillary thyroid cancer: A case-control study.

Head Neck 2019 Feb 13. Epub 2019 Feb 13.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Background: This study was to investigate the association of fasting serum glucose (FSG), thyroid-stimulating hormone (TSH), and thyroid hormones with papillary thyroid cancer (PTC).

Methods: A total of 649 participants were included in this case-control study. The associations of FSG, TSH, free triiodothyronine (FT3) and free thyroxine (FT4) with PTC were estimated using an unconditional logistic regression. Read More

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http://dx.doi.org/10.1002/hed.25691DOI Listing
February 2019

Combination therapy of an iNKT cell ligand and CD40-CD154 blockade establishes islet allograft acceptance in nonmyeloablative bone marrow transplant recipients.

Acta Diabetol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

Aims: Islet transplantation is an effective therapeutic option for type 1 diabetes. Although maintenance immunosuppression therapy is required to prevent allogeneic rejection and recurrence of autoimmunity, long-term allograft survival has not yet been achieved partly because of its adverse effects. The induction of donor-specific immunotolerance is a promising approach for long-term allograft survival without maintenance immunosuppression therapy. Read More

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http://dx.doi.org/10.1007/s00592-019-01289-7DOI Listing
February 2019
2.399 Impact Factor

Helminths protect against type 1 diabetes: effects and mechanisms.

Parasitol Res 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, People's Hospital of Songzi City, Songzi, 434200, Hubei, China.

Type 1 diabetes (T1D) is an autoimmune disease in which cells of the immune system destroy pancreatic β cells, which secrete insulin. The high prevalence of T1D in developed societies may be explained by environmental changes, including lower exposure to helminths. Indeed, infection by helminths such as Schistosoma, Filaria, and Heligmosomoides polygyrus and their by-products has been reported to ameliorate or prevent the development of T1D in human and animal models. Read More

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http://dx.doi.org/10.1007/s00436-019-06247-4DOI Listing
February 2019

Effectiveness of a Behavior Change Technique-Based Smartphone Game to Improve Intrinsic Motivation and Physical Activity Adherence in Patients With Type 2 Diabetes: Randomized Controlled Trial.

JMIR Serious Games 2019 Feb 13;7(1):e11444. Epub 2019 Feb 13.

Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.

Background: Regular physical activity (PA) is an essential component of a successful type 2 diabetes treatment. However, despite the manifest evidence for the numerous health benefits of regular PA, most patients with type 2 diabetes remain inactive, often due to low motivation and lack of PA enjoyment. A recent and promising approach to help overcome these PA barriers and motivate inactive individuals to change their PA behavior is PA-promoting smartphone games. Read More

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http://dx.doi.org/10.2196/11444DOI Listing
February 2019

Meta-analysis on the association between the frequency of tooth brushing and diabetes mellitus risk.

Diabetes Metab Res Rev 2019 Feb 13:e3141. Epub 2019 Feb 13.

School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China.

Background And Objective: Epidemiological studies suggested that the frequency of tooth brushing might be associated with the risk of diabetes mellitus (DM), but the results were inconsistent and no systematic review was conducted to focus on this topic. In this meta-analysis, we synthesized available observational epidemiological evidences to identify the association between tooth brushing and DM risk and investigate the potential dose-response relationship of them.

Methods: We searched PubMed and Embase from their inception through December 2017 to identify observational studies examining the association between tooth brushing and the risk of DM. Read More

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http://dx.doi.org/10.1002/dmrr.3141DOI Listing
February 2019

Synergic effects of oxygen supply and antioxidants on pancreatic β-cell spheroids.

Sci Rep 2019 Feb 12;9(1):1802. Epub 2019 Feb 12.

Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama, 240-8501, Japan.

Diabetes is one of the most common metabolic disorders, and is characterized by the inability to secrete/sense insulin and abnormal blood glucose concentration. Many researchers have concentrated their efforts on improving islet transplantation, in particular by fabricating bioartificial pancreatic islets in vitro. One of the critical points for the success of this research direction is the improvement of culture conditions, such as oxygen supply, in the engineering of bioartificial pancreatic islets to ensure their viability and functionality after transplantation. Read More

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http://dx.doi.org/10.1038/s41598-018-38011-6DOI Listing
February 2019

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors.

Cell Death Dis 2019 Feb 12;10(2):128. Epub 2019 Feb 12.

Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, PR China.

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer's disease, Prion diseases, type 2 diabetes, and some infectious diseases. It has been found that a variety of stimuli including danger-associated molecular patterns (DAMPs, such as silica and uric acid crystals) and pathogen-associated molecular patterns (PAMPs) can activate NLRP3 inflammasome, but the specific regulatory mechanisms of NLRP3 inflammasome activation remain unclear. Read More

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http://www.nature.com/articles/s41419-019-1413-8
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http://dx.doi.org/10.1038/s41419-019-1413-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372664PMC
February 2019
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Diabetic macular oedema and diode subthreshold micropulse laser (DIAMONDS): study protocol for a randomised controlled trial.

Trials 2019 Feb 12;20(1):122. Epub 2019 Feb 12.

The Northern Ireland Clinical Trials Unit (NICTU), Belfast, UK.

Background: In the UK, macular laser is the treatment of choice for people with diabetic macular oedema with central retinal subfield thickness (CST) < 400 μm, as per National Institute for Health and Care Excellence guidelines. It remains unclear whether subthreshold micropulse laser is superior and should replace standard threshold laser for the treatment of eligible patients.

Methods: DIAMONDS is a pragmatic, multicentre, allocation-concealed, randomised, equivalence, double-masked clinical trial that aims to determine the clinical effectiveness and cost-effectiveness of subthreshold micropulse laser compared with standard threshold laser, for the treatment of diabetic macular oedema with CST < 400 μm. Read More

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http://dx.doi.org/10.1186/s13063-019-3199-5DOI Listing
February 2019
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Separate and combined associations of physical activity and obesity with lipid-related indices in non-diabetic and diabetic patients.

Lipids Health Dis 2019 Feb 12;18(1):49. Epub 2019 Feb 12.

Institute of Health Management, Chinese PLA General Hospital, No.28, Fuxing Road, Haidian District, Beijing, 100853, People's Republic of China.

Background: This study evaluated the separate and combined associations of physical activity and obesity with blood lipids in Chinese adults with and without diabetes.

Methods: Data of 17,535 participants aged 18 to 78 years old were collected. Physical activity was categorized as inactive (low) or active (moderate or high) according to the International Physical Activity Questionnaire. Read More

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http://dx.doi.org/10.1186/s12944-019-0987-6DOI Listing
February 2019

Urban environment as an independent predictor of insulin resistance in a South Asian population.

Int J Health Geogr 2019 Feb 12;18(1). Epub 2019 Feb 12.

PURSE-HIS Study Center, Sri Ramachandra University, Chennai, India.

Background: Developing countries, such as India, are experiencing rapid urbanization, which may have a major impact on the environment: including worsening air and water quality, noise and the problems of waste disposal. We used health data from an ongoing cohort study based in southern India to examine the relationship between the urban environment and homeostasis model assessment of insulin resistance (HOMA-IR).

Methods: We utilized three metrics of urbanization: distance from urban center; population density in the India Census; and satellite-based land cover. Read More

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http://dx.doi.org/10.1186/s12942-019-0169-9DOI Listing
February 2019

Early risk assessment of circulating endothelial progenitor cells and plasma stromal cell-derived factor-1 for nondisabling ischemic cerebrovascular events.

BMC Neurol 2019 Feb 12;19(1):22. Epub 2019 Feb 12.

Department of Neurology, Second Peoples Hospital of Chengdu, Chengdu, 610000, Sichuan Province, China.

Background: Endothelial progenitor cells (EPCs) play an important role in ischemic stroke. However, there are few studies on the relationship between EPC and nondisabling ischemic cerebrovascular events. Our aim was to investigate the association of EPCs and SDF-1 (serum stromal cell-derived factor-1) with NICE (nondisabling ischemic cerebrovascular events). Read More

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http://dx.doi.org/10.1186/s12883-019-1250-5DOI Listing
February 2019

Hepatoprotective activity of metformin: A new mission for an old drug?

Eur J Pharmacol 2019 Feb 10;850:1-7. Epub 2019 Feb 10.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Metformin, as a dimethyl biguanide prescribed as the first-line medication for treatment of type 2 diabetes mellitus, is one of the most frequently used drugs, worldwide. However, the beneficial effects of metformin are not limited to insulin sensitizing and blood glucose lowering effects as recent clinical trials deciphered lower cancer risk in metformin users. In addition, metformin protected the liver against chemical or viral hepatotoxicants through various mechanisms including activation of AMPK via inhibition of mitochondrial complex I, inhibition of mitogen activated protein kinase (MAPK) and inhibition of Smads phosphorylation. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.004DOI Listing
February 2019
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Metformin alters human host responses to Mycobacterium tuberculosis in healthy subjects.

J Infect Dis 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Background: Metformin, the most widely administered diabetes drug, has been proposed as a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its effects on human host responses to Mycobacterium tuberculosis.

Methods: We investigated in-vitro and in-vivo effects of metformin in humans.

Results: Metformin added to peripheral blood mononuclear cells from healthy volunteers enhanced in-vitro cellular metabolism whilst inhibiting the mammalian target of rapamycin (mTOR) targets p70S6K and 4EBP1, with decreased cytokine production and cellular proliferation, and increased phagocytosis. Read More

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http://dx.doi.org/10.1093/infdis/jiz064DOI Listing
February 2019
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Plasma alkylresorcinol metabolite, a biomarker of whole-grain wheat and rye intake, and risk of ischemic stroke: a case-control study.

Am J Clin Nutr 2019 Feb;109(2):1-7

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety.

Background: Epidemiologic studies on whole grains and risk of stroke have reported inconsistent results, with some suggesting a protective effect but others showing a null association.

Objectives: The aim of this study was to examine whether plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, is associated with risk of ischemic stroke.

Methods: A hospital-based case-control study was conducted between March 2011 and May 2016. Read More

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http://dx.doi.org/10.1093/ajcn/nqy323DOI Listing
February 2019
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Hallmarks of improved immunological responses in the vaccination of more physically active elderly females.

Exerc Immunol Rev 2019 ;25:20-33

Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos, Singapore.

Physical inactivity is one of the leading contributors to worldwide morbidity and mortality. The elderly are particularly susceptible since the features of physical inactivity overlap with the outcomes of natural aging - including the propensity to develop cardiovascular diseases, cancer, diabetes mellitus, sarcopenia and cognitive impairment. The age-dependent loss of immune function, or immunosenescence, refers to the progressive depletion of primary immune resources and is linked to the development of many of these conditions. Read More

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January 2019
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Expression Changes of NMDA and AMPA Receptor Subunits in the Hippocampus in rats with Diabetes Induced by Streptozotocin Coupled with Memory Impairment.

Neurochem Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, 1168 West Chunrong Road, Kunming, 650500, People's Republic of China.

Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR); however, the pathogenesis involved in this has not been fully understood, especially at early phase of DM. Here, we sought to determine the cognitive changes and aim to correlate this with the expression changes of NMDAR and AMPAR of glutamate signaling pathways in the rat hippocampus from early phase of DM and in the course of the disease progression. Read More

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http://dx.doi.org/10.1007/s11064-019-02733-4DOI Listing
February 2019

Mitochondria Associated Membranes (MAMs): Emerging drug targets for diabetes.

Curr Med Chem 2019 Feb 12. Epub 2019 Feb 12.

Biochemistry and Molecular Mechanism Laboratory Agro-processing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram, Kerala. India.

MAMs, the physical association between the endoplasmic reticulum (ER) and mitochondria are functional domains, performing a significant role in the maintenance of cellular homeostasis. It is evolving as an important signaling center that coordinates nutrient and hormonal signaling for the proper regulation of hepatic insulin action and glucose homeostasis. Moreover, MAMs can be considered as hot spots for the transmission of stress signals from ER to mitochondria. Read More

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http://dx.doi.org/10.2174/0929867326666190212121248DOI Listing
February 2019
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Anti-inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways.

J Cell Physiol 2019 Feb 11. Epub 2019 Feb 11.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. Read More

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http://dx.doi.org/10.1002/jcp.28315DOI Listing
February 2019
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Prompting Patients with Poorly Controlled Diabetes to Identify Visit Priorities Before Primary Care Visits: a Pragmatic Cluster Randomized Trial.

J Gen Intern Med 2019 Feb 11. Epub 2019 Feb 11.

Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA.

Background: Most patients with diabetes do not meet all evidence-based goals of care, and many patients report poor communication and lack of involvement in decision-making during primary care visits.

Objective: To test the hypothesis that a "Pre-Visit Prioritization" secure email message could improve visit communication and glycemic control among patients with type 2 diabetes.

Design: We conducted a pragmatic, provider-randomized, multi-site clinical trial from March 2015 to October 2016 across 30 primary care practices within Kaiser Permanente Northern California (KPNC), a large integrated care delivery system. Read More

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http://dx.doi.org/10.1007/s11606-018-4756-4DOI Listing
February 2019