22,173 results match your criteria Diabetes Technology & Therapeutics[Journal]


The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs.

J Cell Physiol 2019 Apr 24. Epub 2019 Apr 24.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Diabetes mellitus (DM) and cancer are global problems carrying huge human, social, and economic impact. Type 2 diabetes (T2DM) is associated with an increased risk for a number of cancers, including breast, pancreatic, and liver cancer. Moreover, adverse drug reactions are higher in paitents with cancer with T2DM compared to cancer patients without T2DM. Read More

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http://dx.doi.org/10.1002/jcp.28644DOI Listing

Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus.

J Cachexia Sarcopenia Muscle 2019 Apr 23. Epub 2019 Apr 23.

Foundation for Diabetes Research in Older People, Diabetes Frail Ltd, Luton, UK.

Background: Type 2 diabetes, a highly prevalent chronic disease, is associated with increasing frailty and functional decline in older people. We aimed to evaluate the effectiveness of a multimodal intervention on functional performance in frail and pre-frail participants aged ≥70 years with type 2 diabetes mellitus.

Methods: The MID-Frail study was a cluster-randomized multicenter clinical trial conducted in 74 trial sites across seven European countries. Read More

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http://dx.doi.org/10.1002/jcsm.12432DOI Listing

Association of Interleukin-6 -174G/C Polymorphism with the Risk of Diabetic Nephropathy in Type 2 Diabetes: A Meta-analysis.

Curr Med Sci 2019 Apr 23;39(2):250-258. Epub 2019 Apr 23.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Previous studies reported the association between interleukin-6 (IL-6) -174G/C gene polymorphism and the risk of diabetic nephropathy in type 2 diabetes mellitus (T2DN). However, the results remain controversial. In the present study, we conducted a meta-analysis to further examine this relationship between IL-6-174G/C gene polymorphism and T2DN. Read More

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http://dx.doi.org/10.1007/s11596-019-2027-1DOI Listing

Safety and Efficacy of Bipolar Radiofrequency Ablation Device in Hemostasis during Thyroidectomy in Comparison with Ultrasonic Scalpel: A Comparative Study.

Indian J Endocrinol Metab 2019 Jan-Feb;23(1):76-80

The Specialized Endocrine and Diabetes Center, Al-Mawani Teaching Hospital, Basra, Iraq.

Aim: Ultrasonic scalpel is one of the recent advances in surgical technology. The main limitation of their use is the cost. However, radiofrequency ablation device is a refined type of electrosurgical cautery that can be used with conventional reusable bipolar cautery forceps. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_519_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446675PMC

Pharmacological Evaluation of Secondary Metabolites and Their Simultaneous Determination in the Arabian Medicinal Plant Using HPTLC Validated Method.

J Anal Methods Chem 2019 19;2019:7435909. Epub 2019 Mar 19.

National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Oxford 38677, USA.

is an important genus of the Loranthaceae family, and it is a semiparasitic plant grown in Saudi Arabia, traditionally used as a cure for diabetes and cancer in human and for increasing lactation in cattle. A flavonoid quercetin (), (-)-catechin (), and a flavane gallate 2S,3R-3,3',4',5,7-pentahydroxyflavane-5-O-gallate () were isolated from the methanol extract of the aerial parts of (PCME). The PCME and the isolated compounds were subjected to pharmacological assays to estimate peroxisome proliferator-activated receptors PPAR and PPAR agonistic, anti-inflammatory, cytotoxic, and antimicrobial activities. Read More

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http://dx.doi.org/10.1155/2019/7435909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444227PMC

A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation.

Chem Sci 2019 Apr 27;10(14):3976-3986. Epub 2019 Feb 27.

Biophysics and Department of Chemistry , University of Michigan , Ann Arbor , MI 48109-1055 , USA . Email:

In humans, β-amyloid and islet amyloid polypeptide (IAPP, also known as amylin) aggregations are linked to Alzheimer's disease and type-2 diabetes, respectively. There is significant interest in better understanding the aggregation process by using chemical tools. Here, we show the ability of a cationic polymethacrylate-copolymer (PMAQA) to quickly induce a β-hairpin structure and accelerate the formation of amorphous aggregates of β-amyloid-1-40, whereas it constrains the conformational plasticity of amylin for several days and slows down its aggregation at substoichiometric polymer concentrations. Read More

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http://dx.doi.org/10.1039/c8sc05771kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457205PMC

Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic Cell Identity in db/db Mice.

Evid Based Complement Alternat Med 2019 19;2019:1232913. Epub 2019 Mar 19.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, China.

Huanglian-Renshen-Decoction (HRD) is widely used to treat type 2 diabetes mellitus (T2DM) in China. However, the underlying mechanism is unclear. We aimed to investigate the mechanism by which HRD regulates the glucose level. Read More

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http://dx.doi.org/10.1155/2019/1232913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444265PMC

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.

Nat Commun 2019 Apr 23;10(1):1835. Epub 2019 Apr 23.

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.

Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are decreased in rats with limited proteinuria. In experimental models of diabetes, phenyl sulfate administration induces albuminuria and podocyte damage. Read More

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http://dx.doi.org/10.1038/s41467-019-09735-4DOI Listing

Hemoglobin A1c and 10-year information processing speed in Japanese community dwellers.

Environ Health Prev Med 2019 Apr 23;24(1):24. Epub 2019 Apr 23.

Section of NILS-LSA, National Center for Geriatrics and Gerontology, 7-430, Morioka-cho, Obu, Aichi, 474-8511, Japan.

Background: Hyperglycemia is believed to be a risk factor for cognitive decline, but the longitudinal relationship between hyperglycemia and cognitive decline in the Japanese population is unclear. The present study aimed to clarify the association between blood glucose levels and information processing ability in middle-aged and older adults.

Methods: The subjects were 866 men and 815 women aged 40-79 years not taking medication for diabetes who participated in the first study wave (1997-2000) and then participated at least once in the subsequent six study waves (2000-2012) of the National Institute for Longevity Sciences-Longitudinal Study of Aging, Japan. Read More

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http://dx.doi.org/10.1186/s12199-019-0778-8DOI Listing

A Selective Role of Dietary Anthocyanins and Flavan-3-ols in Reducing the Risk of Type 2 Diabetes Mellitus: A Review of Recent Evidence.

Nutrients 2019 Apr 13;11(4). Epub 2019 Apr 13.

Department of Food Science and Nutrition, Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL 60616, USA.

Type 2 diabetes mellitus (T2DM) is the most common form of DM and its prevalence is increasing worldwide. Because it is a progressive disease, prevention, early detection and disease course modification are possible. Diet plays a critical role in reducing T2DM risk. Read More

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http://dx.doi.org/10.3390/nu11040841DOI Listing

Anti-Obesity Effects of Tocotrienols and Bran in High-Fat Diet-Treated Mice.

Nutrients 2019 Apr 12;11(4). Epub 2019 Apr 12.

Molecular Cell Biology Laboratory, Systems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Fukasaku 307, Minuma-ku, Saitama 337-8570, Japan.

Obesity is a serious public health issue in developed countries, and is known to increase the risk of several diseases such as diabetes, cardiovascular events and arteriosclerosis. These phenomena are closely correlated with oxidative damage. Recently, several lines of evidence have demonstrated that neurodegenerative diseases such as Alzheimer's and Parkinson's are also related to oxidative damage. Read More

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http://dx.doi.org/10.3390/nu11040830DOI Listing

Memory and Learning Complaints in Relation to Depression among Elderly People with Multimorbidity.

Geriatrics (Basel) 2017 May 9;2(2). Epub 2017 May 9.

Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Although current models of care are generally well-suited to providing treatment for individual medical conditions, the emergence of multimorbidity is becoming a serious concern for practitioners and policy researchers, particularly in developing countries. The challenges of tackling multimorbidity are further compounded when the multimorbidity co-occurs with psychiatric conditions such as cognitive and depressive disorders. Understanding the relationships between multimorbidity and psychiatric illnesses is therefore of considerable clinical importance. Read More

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http://dx.doi.org/10.3390/geriatrics2020015DOI Listing

Hypertension Contributes to Neuropathy in Patients with Type 1 Diabetes.

Am J Hypertens 2019 Apr 23. Epub 2019 Apr 23.

Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.

Background: Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and amputation. There are currently no disease modifying therapies for DPN. The aim of this study was to determine if hypertension contributes to DPN in patients with T1DM. Read More

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http://dx.doi.org/10.1093/ajh/hpz058DOI Listing

Into the deep blue sea: A review of the safety of recreational diving in people with diabetes mellitus.

Eur J Sport Sci 2019 Apr 23:1-16. Epub 2019 Apr 23.

a Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School , Aristotle University of Thessaloniki, AHEPA University Hospital , Thessaloniki , Greece.

People with diabetes, particularly those being insulin treated, have been for many years considered ineligible for diving, because of the high risk of adverse events. Blood glucose levels tend to decline during diving, probably because of changes in insulin requirements and resistance, due to increased physical activity and effects of hyperbaric environment on glucose tolerance. Strict adherence to safety protocols, in conjunction with optimal physical status, lack of diabetic complications (especially impaired awareness of hypoglycaemia) and satisfactory baseline glycaemic control, seem to minimise the risk of complications during diving. Read More

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https://www.tandfonline.com/doi/full/10.1080/17461391.2019.1
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http://dx.doi.org/10.1080/17461391.2019.1606286DOI Listing
April 2019
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Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Sciences, School of Allied Health Sciences, Walailak Univ., Nakhon Si Thammarat, 80161, Thailand.

Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)-induced T2D nephropathy of albino mice. Read More

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http://dx.doi.org/10.1111/1750-3841.14511DOI Listing

A randomized controlled trial of a wearable technology-based intervention for increasing moderate to vigorous physical activity and reducing sedentary behavior in breast cancer survivors: The ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: The benefits of an active lifestyle after a breast cancer diagnosis are well recognized, but the majority of survivors are insufficiently active. The ACTIVATE Trial examined the efficacy of an intervention (use of the Garmin Vivofit 2 activity monitor coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions) to increase moderate to vigorous physical activity (MVPA) and reduce sedentary behavior in breast cancer survivors.

Methods: This randomized controlled trial recruited 83 inactive, postmenopausal women diagnosed with stage I-III breast cancer who had completed primary treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32143
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http://dx.doi.org/10.1002/cncr.32143DOI Listing
April 2019
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Maintenance of physical activity and sedentary behavior change, and physical activity and sedentary behavior change after an abridged intervention: Secondary outcomes from the ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: This brief report examines the maintenance of moderate to vigorous physical activity (MVPA) and sedentary behavior changes approximately 12 weeks after the delivery of the ACTIVATE Trial primary intervention (use of the Garmin Vivofit 2 activity tracker coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions). We also examine the efficacy of an abridged intervention (use of the Garmin Vivofit 2 only) in the waitlist control group.

Methods: A pre-post design was employed to examine the secondary aims of the ACTIVATE Trial (n = 80; mean age = 62 years). Read More

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http://dx.doi.org/10.1002/cncr.32142DOI Listing

A Noninvasive, Economical, and Instant-Result Method to Diagnose and Monitor Type 2 Diabetes Using Pulse Wave: Case-Control Study.

JMIR Mhealth Uhealth 2019 Apr 23;7(4):e11959. Epub 2019 Apr 23.

Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of Traditional Chinese Medicine Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: We should pay more attention to the long-term monitoring and early warning of type 2 diabetes and its complications. The traditional blood glucose tests are traumatic and cannot effectively monitor the development of diabetic complications. The development of mobile health is changing rapidly. Read More

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http://dx.doi.org/10.2196/11959DOI Listing

Validating the Sedentary Sphere method in children: Does wrist or accelerometer brand matter?

J Sports Sci 2019 Apr 23:1-9. Epub 2019 Apr 23.

a Physical Activity Exchange, Research Institute of Sport and Exercise Sciences , Liverpool John Moores University , Liverpool , UK.

This study aimed to validate the Sedentary Sphere posture classification method from wrist-worn accelerometers in children. Twenty-seven 9-10-year-old children wore ActiGraph GT9X (AG) and GENEActiv (GA) accelerometers on both wrists, and activPAL on the thigh while completing prescribed activities: five sedentary activities, standing with a phone, walking (criterion for all 7: observation) and 10-min free-living play (criterion: activPAL). In an independent sample, 21 children wore AG and GA accelerometers on the non-dominant wrist and activPAL for two days of free-living. Read More

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https://www.tandfonline.com/doi/full/10.1080/02640414.2019.1
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http://dx.doi.org/10.1080/02640414.2019.1605647DOI Listing
April 2019
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Reduced medical spending associated with increased use of a remote diabetes management program and lower mean blood glucose values.

J Med Econ 2019 Apr 23. Epub 2019 Apr 23.

d Eli Lilly and Company , Indianapolis , IN , USA.

Aims: Many new mobile technologies are available to assist people in managing chronic conditions, but data on the association between the use of these technologies and medical spending remains limited. As the available digital technology offerings to aid in diabetes management increase, it is important to understand their impact on medical spending. The aim of this study was to investigate the financial impact of a remote digital diabetes management program using medical claims and real-time blood glucose data. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609483DOI Listing

Cost Effectiveness of Treatments for Diabetic Retinopathy: A Systematic Literature Review.

Pharmacoeconomics 2019 Apr 22. Epub 2019 Apr 22.

NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK.

Background: Diabetic retinopathy (DR) affects approximately one-third of people diagnosed with diabetes, can be sight-threatening, and generates significant human and economic burden. Over the last 2 decades, newer therapies have emerged, offering significant clinical benefits, however at a cost. Given the scarcity of available budgets, the cost effectiveness of these newer treatments is of vital importance to policy makers. Read More

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http://dx.doi.org/10.1007/s40273-019-00800-wDOI Listing

Identification of α-glucosidase inhibitors from leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking.

J Pharm Anal 2019 Apr 15;9(2):91-99. Epub 2018 Nov 15.

Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang Darul Makmur, Malaysia.

The present study used and techniques, as well as the metabolomics approach to characterise α-glucosidase inhibitors from different fractions of is a medicinal plant belonging to the Acanthaceae family, and is traditionally used to treat diabetes in Malaysia. Hexane, hexane: ethyl acetate (1:1, v/v), ethyl acetate, ethyl acetate: methanol (1:1, v/v), and methanol fractions were obtained via partitioning of the 80% methanolic crude extract. The α-glucosidase inhibitory activity was analyzed using all the fractions collected, followed by profiling of the metabolites using liquid chromatography combined with mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.jpha.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460329PMC

Investigating the Enduring Impact of a Community-Based Health Education Program to Promote African American Elders' Use of Technology Designed to Support Chronic Disease Self-Management.

Geriatrics (Basel) 2018 Oct 13;3(4). Epub 2018 Oct 13.

School of Communication and Information, Rutgers University, New Brunswick, NJ 08901, USA.

Elders experience chronic disease disparities and barriers to access technology designed to support recommended self-management behaviors. Elders from racial minority groups are among those who experience particular disparities in chronic disease incidence, outcomes, and barriers to technology use. In order to investigate strategies to address barriers, the study team recruited elder African Americans with diabetes and young adults connected to the elders through naturally occurring familial or social networks. Read More

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http://dx.doi.org/10.3390/geriatrics3040070DOI Listing
October 2018

Diabetes, Care Homes, and the Influence of Technology on Practice and Care Delivery in Care Homes: Systematic Review and Qualitative Synthesis.

JMIR Diabetes 2019 Apr 22;4(2):e11526. Epub 2019 Apr 22.

Division of Rural Health and Wellbeing, Centre for Health Science, University of the Highlands and Islands, Inverness, United Kingdom.

Background: Diabetes is increasing in prevalence and complexity in the care home setting, affecting up to a quarter of care home residents. Health outcomes for these residents are impacted by management of the disease, health care professionals (HCPs)' decision-making skills within the care home setting, and access to specialist services. The use of technology has the potential to recognize opportunities for early intervention that enables efficient responsive care, taking a fundamental role in linking the care home community to wider multidisciplinary teams for support. Read More

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http://dx.doi.org/10.2196/11526DOI Listing

Adaptive Optics (rtx1) High-Resolution Imaging of Photoreceptors and Retinal Arteries in Patients with Diabetic Retinopathy.

J Diabetes Res 2019 17;2019:9548324. Epub 2019 Mar 17.

Medical University of Warsaw, Department of Ophthalmology, Warsaw, Poland.

Background: Diabetic retinopathy (DR) is the leading cause of impaired vision in patients with diabetes mellitus. An adaptive optics retinal camera (rtx1™; Imagine Eyes, France) was used to capture images of cones and retinal arteries from patients with DR.

Objective: Cone parameters (density, interphotoreceptor distance, and regularity) and retinal artery parameters (wall thickness, lumen diameter, WLR, and WCSA) were analyzed in 36 patients with nonproliferative DR (NPDR; 22 with mild NPDR and 14 with moderate NPDR) and in 20 healthy volunteers (the control group). Read More

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http://dx.doi.org/10.1155/2019/9548324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441527PMC

Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 in human periodontal ligament fibroblasts.

J Cell Biochem 2019 Apr 21. Epub 2019 Apr 21.

Department of Oral Biochemistry, Field of Developmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Periodontal ligament fibroblasts (PDLFs) have osteogenic capacity, producing bone matrix proteins. Application of bone morphogenic proteins (BMPs) to PDLFs is a promising approach for periodontal regeneration. However, in chronic bone metabolic disorders, such as periodontitis, proper control of accompanying inflammation is essential for optimizing the effects of BMPs on PDLFs. Read More

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http://dx.doi.org/10.1002/jcb.28727DOI Listing

Hidden blood loss and its risk factors in patients undergoing laparoscopy and laparotomy for cervical cancer management.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynaecology and Obstetrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.

Purpose: Laparoscopy and laparotomy are the two most common surgical options used to treat women with early-stage cervical cancer. This study aimed to examine the volume of hidden blood loss (HBL) between laparoscopy and laparotomy for cervical cancer and to identify its risk factors.

Methods: Sixty-one patients treated with laparotomy and 50 patients treated with laparoscopy were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s00404-019-05162-4DOI Listing

The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose-response of randomized clinical trials.

Clin Transl Oncol 2019 Apr 22. Epub 2019 Apr 22.

School of Public Health and Health Management, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.

Purpose: Breast cancer is a leading cause of cancer mortality in developed countries. We performed a meta-analysis of randomized clinical trials to investigate the effect of metformin on biomarkers associated with breast cancer outcomes and to explore the dose-response relationship.

Methods: A systematic search was performed from onset of the database to January 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane library to identify randomized clinical trials investigating the impact of metformin on insulin, glucose, CRP, leptin, body mass indices (BMI), cholesterol, Ki-67, and Homeostatic Model Assessment for Insulin-Resistance (HOMA-IR). Read More

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http://dx.doi.org/10.1007/s12094-019-02108-9DOI Listing

Higher Numbers of Pregnancies Associated with an Increased Prevalence of Gestational Diabetes Mellitus: Results from the Healthy Baby Cohort Study.

J Epidemiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology.

BackgroundPregnancy leads to substantial maternal metabolic and lifestyle alterations. However, it is still unclear whether repeated exposure to these changes will influence the development of gestational diabetes mellitus (GDM). In the present study, we aimed to investigate the association between the number of pregnancies and GDM among Chinese women. Read More

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https://www.jstage.jst.go.jp/article/jea/advpub/0/advpub_JE2
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http://dx.doi.org/10.2188/jea.JE20180245DOI Listing
April 2019
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Correlation of factors associated with postoperative infection in patients with malignant oral and maxillofacial tumours: a logistic regression analysis.

Br J Oral Maxillofac Surg 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430074.

Patients with oral and maxillofacial malignant tumours have a relatively high incidence of postoperative infections. We have analysed the risk factors and the distribution of pathogens in infected patients to try and find out how to prevent them. We recruited 312 patients over 60 years old with malignant oral and maxillofacial tumours and investigated their incidence of postoperative infection between January 2007 and December 2017. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.04.003DOI Listing

Time-dependent functional, morphological, and molecular changes in diabetic bladder dysfunction in streptozotocin-induced diabetic mice.

Neurourol Urodyn 2019 Apr 20. Epub 2019 Apr 20.

Department of pharmacology of Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Aim: Diabetic bladder dysfunction (DBD) is one of the most common and bothersome complications of diabetes mellitus (DM). This study aimed to investigate the functional, structural, and molecular changes of the bladder at 0, 3, 6, 9, and 12 weeks after DM induction by streptozotocin (STZ) in male C57BL/6 mice.

Methods: Male C57BL/6J mice were injected with STZ (130 mg/kg). Read More

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http://dx.doi.org/10.1002/nau.24008DOI Listing

Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Department of Clinical Science, KG Jebsen Centre for Diabetes Research, University of Bergen, Bergen, Norway.

Background: Elevated circulating cystathionine levels are related to atherosclerotic cardiovascular disease, a leading cause of death globally.

Objective: We investigated whether plasma cystathionine was associated with mortality in patients with suspected or established coronary heart disease (CHD).

Methods: Data from 2 independent cohorts of patients with suspected stable angina pectoris (SAP) (3033 patients; median 10. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqy391DOI Listing
April 2019
1 Read

Rapid automatic identification of parameters of the Bergman Minimal Model in Sprague-Dawley rats with experimental diabetes for adaptive insulin delivery.

Comput Biol Med 2019 Apr 8;108:242-248. Epub 2019 Apr 8.

IEEE Engineering in Medicine and Biology, Mexico City, Mexico. Electronic address:

Glucose-Insulin regulation models can be used to individualize insulin therapy. However, the experimental techniques currently used to identify the appropriate parameter sets of an individual are expensive, time consuming, and very unpleasant for the patient. Since there is a wide range of intrapersonal parameter variability, the identified parameters in a laboratory setting (at rest) are not optimal for dynamic conditions of daily activities. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.028DOI Listing

Insulin transcriptionally down-regulates carboxylesterases through pregnane X receptor in an Akt-dependent manner.

Toxicology 2019 Apr 18. Epub 2019 Apr 18.

Department of Pharmacology, School of Basic Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address:

Insulin is a major therapy for diabetes, and therefore, its role and mechanisms in the regulation of drug-metabolizing enzymes (DMEs), is of clinical importance to facilitate the rational drug use. Carboxylesterases are regarded as one of the major determinants of the metabolism and disposition of various substrates through their actions in the liver and intestine, alterations in the activity of CESs enzymes are often important causes of drug interactions. Therefore, investigation on the mechanism of CESs regulation is significantly important. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X183056
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http://dx.doi.org/10.1016/j.tox.2019.04.008DOI Listing
April 2019
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The present and future of deep learning in radiology.

Eur J Radiol 2019 May 2;114:14-24. Epub 2019 Mar 2.

Stroke Monitoring and Diagnostic Division, AtheroPoint™, Roseville, CA, USA. Electronic address:

The advent of Deep Learning (DL) is poised to dramatically change the delivery of healthcare in the near future. Not only has DL profoundly affected the healthcare industry it has also influenced global businesses. Within a span of very few years, advances such as self-driving cars, robots performing jobs that are hazardous to human, and chat bots talking with human operators have proved that DL has already made large impact on our lives. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193009
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http://dx.doi.org/10.1016/j.ejrad.2019.02.038DOI Listing
May 2019
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Circulating neuromedin U levels are similar in subjects with NGT and newly diagnosed T2DM and do not correlate with insulin secretion.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Department of Endocrinology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. Electronic address:

Aims: Neuromedin U (NMU), a highly conserved peptide, is implicated in energy homeostasis and is involved in regulating insulin secretion as a decretin hormone in animals. However, there have been no reports on the relationship between NMU and type 2 diabetes mellitus (T2DM). The aim of this study was to investigate circulating NMU concentrations in healthy subjects and T2DM patients and to evaluate the association between serum NMU levels and glucose-stimulated insulin secretion. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.020DOI Listing

A contemporary biological pathway of islet amyloid polypeptide for the management of diabetic dementia.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, NSW 2007, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, The University of Newcastle (UoN), Callaghan, NSW 2308, Australia. Electronic address:

Major challenges of dealing elder patients with diabetes mellitus (DM) are the individualization of consideration in persons with various comorbid types of conditions. In spite of the fact that microvascular and macrovascular problems associated with DM are well documented, there is only a few numbers of reports viewing different conditions, for example, cognitive dysfunction. Cognitive dysfunction is of specific significance due to its effect on self-care and quality of life. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.022DOI Listing

Detection rate of unknown primary tumour by using somatostatin receptor PET/CT in patients with metastatic neuroendocrine tumours: a meta-analysis.

Endocrine 2019 Apr 19. Epub 2019 Apr 19.

Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Bellinzona, Switzerland.

Purpose: The high diagnostic performance of somatostatin receptor positron emission tomography with computed tomography (PET/CT) in neuroendocrine tumours (NETs) was demonstrated by several articles. However, only some studies evaluated the detection rate (DR) of this imaging method in patients with metastatic NETs and unknown primary tumours (CUP-NETs). Therefore, we aimed to perform a meta-analysis to add evidence-based data in this setting. Read More

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http://dx.doi.org/10.1007/s12020-019-01934-9DOI Listing

Study Protocol for a Prospective, Multicenter, Randomized, Open-Label, Parallel-Group Clinical Trial Comparing the Efficacy and Safety of a Needle-Free Insulin Injector and a Conventional Insulin Pen in Controlling Blood Glucose Concentrations in Chinese Patients with Type 2 Diabetes Mellitus (The FREE Study).

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

Department of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Introduction: China has the largest number of diabetic patients in the world. In the past 2 decades, the prevalence of diabetes in China has increased dramatically, and the current status of diabetes control in the diabetic population is not satisfactory. Although insulin is currently recognized in diabetes treatment guidelines as the therapeutic option for patients not adequately controlled by diet/exercise and oral agents, the proportion of patients with type 2 diabetes using insulin is still very low, and the time when insulin therapy is initiated is relatively late. Read More

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http://dx.doi.org/10.1007/s12325-019-00951-4DOI Listing

Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.

Mol Cell Biochem 2019 Apr 20. Epub 2019 Apr 20.

Department of Cell and Molecular Biology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, ICMR-Centre for Advanced Research on Diabetes, Gopalapuram, Chennai, 600086, India.

There is a striking interaction of genes and environment in the etiology of type 2 diabetes mellitus (T2DM). While endocrine disrupting chemicals (EDCs) like bisphenol-A (BPA) have received special attention for their mechanistic role in metabolic disruption, there is a lack of clinically relevant data on BPA levels in Asian Indians, a population which is more susceptible to type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Therefore, we measured systemic levels of BPA in patients with T2DM compared to individuals with normal glucose tolerance (n = 30 each). Read More

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http://dx.doi.org/10.1007/s11010-019-03540-9DOI Listing

The effect of luteal GnRH antagonist on moderate and severe early ovarian hyperstimulation syndrome during in vitro fertilization treatment: a prospective cohort study.

Arch Gynecol Obstet 2019 Apr 19. Epub 2019 Apr 19.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, 100034, People's Republic of China.

Purpose: Ovarian hyperstimulation syndrome (OHSS) is a serious complication of assisted reproductive technology (ART) treatment. However, there are limited data regarding the ability of the luteal GnRH antagonist cetrorelix to reduce the incidence of moderate and severe OHSS, and the mechanism remains unclear. Thus, we designed a study to assess the effectiveness of cetrorelix to prevent early moderate and severe OHSS in high-risk patients undergoing controlled ovarian stimulation for IVF/ICSI. Read More

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http://link.springer.com/10.1007/s00404-019-05163-3
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http://dx.doi.org/10.1007/s00404-019-05163-3DOI Listing
April 2019
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Lung cancer survival and comorbidities in lung cancer screening participants of the Gdańsk screening cohort.

Eur J Public Health 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Medical University of Gdańsk, Gdańsk, Poland.

Background: In 2010, the World Health Organisation recommended implementation of screening programmes in four groups of diseases-neoplasms, cardiovascular diseases (CVD), diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD). It is due to the fact that they share the same, modifiable risk factors.

Methods: Between 2009 and 2011, 8637 heavy smokers (aged 50-75, smoking history >20 pack-years) were screened in the Pomeranian Pilot Lung Cancer Screening Programme (PPP) in Gdańsk, Poland. Read More

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http://dx.doi.org/10.1093/eurpub/ckz052DOI Listing

Differential circulating and visceral fat microRNA expression of non-obese and obese subjects.

Clin Nutr 2019 Apr 8. Epub 2019 Apr 8.

Nutrition and Metabolism Research Division, Korea Food Research Institute, Wanju-gun, Republic of Korea; Department of Food Biotechnology, University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

Background & Aims: Altered microRNA (miRNA) expression is associated with the pathophysiology of obesity; however, little is known about the miRNAs commonly dysregulated in the blood and visceral fat tissue of obese patients. This study compared the circulating and visceral fat miRNA expression in subjects with and without obesity.

Methods: For the circulating miRNA study, 20 healthy control and 30 obese subjects were recruited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193014
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http://dx.doi.org/10.1016/j.clnu.2019.03.033DOI Listing
April 2019
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Characteristics of yoga and meditation users among older Australian women - results from the 45 and up study.

Complement Ther Clin Pract 2019 May 6;35:219-223. Epub 2019 Mar 6.

Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney, Sydney, Australia; Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.

Background And Purpose: Yoga and meditation are predominantly utilised by healthy well-educated young women, but little is known about utilisation by older chronically ill women. Therefore, the purpose of this study was to investigate the characteristics of yoga and meditation use among middle-to-higher aged Australian women with chronic conditions.

Materials And Methods: This is a sub-study of the 45 and Up Study including 1925 Australian women aged 53-95 years diagnosed with chronic conditions (asthma, depression, diabetes, osteoarthritis, and osteoporosis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17443881183055
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http://dx.doi.org/10.1016/j.ctcp.2019.03.001DOI Listing
May 2019
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Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.

Neuropsychopharmacology 2019 Apr 19. Epub 2019 Apr 19.

Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.

Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition toward rapid unplanned reactions to stimuli, is one of the multifaceted determinants underlying the etiology of dysregulated eating and its evolving pathogenesis. The medial prefrontal cortex (mPFC) is a major neural director of reward-driven behavior and impulsivity. Read More

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http://dx.doi.org/10.1038/s41386-019-0394-8DOI Listing

Population density is beneficially associated with 12-year diabetes risk marker change among residents of lower socio-economic neighborhoods.

Health Place 2019 Apr 16;57:74-81. Epub 2019 Apr 16.

Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia; Swinburne University of Technology, John Street, Hawthorne, VIC 3122, Hawthorn, Australia.

We examined associations of neighborhood population density with 12-year changes in diabetes risk (post-challenge plasma glucose), and potential moderation by neighborhood socio-economic status (SES) among 4,816 Australians. In lower SES neighborhoods, post-challenge plasma glucose increased by 6% in low-density, remained stable in medium-density and decreased by 3% in high-density neighborhoods. In medium SES neighborhoods, glucose remained stable in high-density, but increased by 2% and 3% in medium- and low-density neighborhoods, respectively. Read More

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http://dx.doi.org/10.1016/j.healthplace.2019.02.006DOI Listing

Ginsenoside Rg1 attenuates hepatic insulin resistance induced by high-fat and high-sugar by inhibiting inflammation.

Eur J Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan, 650500, PR China; Yunnan Province Key Laboratory for Nutrition and Food Safety in Universities, PR China. Electronic address:

Ginsenoside Rg1 is the active ingredient of Chinese herbal medicine ginseng and sanqi, which has remarkable effects on anti-inflammation and anti-diabetes. In this study, we explored the molecular mechanism of ginsenoside Rg1 against diabetes in rat subjected to insulin resistance induced by high-fat and high-sugar (HFHS). Biochemical analysis revealed that ginsenoside Rg1 significantly decreased the serum levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, total cholesterol, triglyceride, low-density lipoprotein and increased the serum levels of high-density lipoprotein, which indicated ginsenoside Rg1 improved the extent of hepatic steatosis. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.027DOI Listing
April 2019
2.532 Impact Factor

Laboratory intervention to improve the request of urinary albumin in primary care patients with arterial hypertension and financial implications.

Clin Biochem 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, University of Missouri, Columbia, MO, USA.

Introduction: The request of Urinary albumin in primary care in Spain is insufficient to monitor patients with diabetes and hypertension (HTN). Our aim was to evaluate a strategy designed in consensus with general practitioners (GPs) to improve the request of urinary albumin in primary care patients with HTN according to guidelines, and to study its financial implications.

Materials And Methods: In a meeting with GPs, we decided that the Laboratory Information System (LIS) would automatically register the albumin-to-creatinine ratio (ACR) test in patients with HTN when the former had not been requested in the previous year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00099120193006
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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.012DOI Listing
April 2019
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