650,242 results match your criteria Diabetes Self-Management [Journal]


Primary cultured neuronal networks and type 2 diabetes model mouse fatty liver tissues in aqueous liquid observed by atmospheric SEM (ASEM): Staining preferences of metal solutions.

Micron 2018 Nov 23;118:9-21. Epub 2018 Nov 23.

Biomedical Research Institute, National Institute of Industrial Science and Technology (AIST), Higashi 1-1-1, Tsukuba, Ibaraki, 305-8566, Japan. Electronic address:

Neural networking, including axon targeting and synapse formation, is the basis of various brain functions, including memory and learning. Diabetes-mellitus affects peripheral nerves and is known to cause fatty liver disease. Electron microscopy (EM) provides the resolution required to observe changes in fine subcellular structures caused by such physiological and pathological processes, but samples are observed in vacuum. Read More

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November 2018

Effectiveness of Fosfomycin Tromethamine Prophylaxis in Preventing Infection Following Ultrasound-guided Prostate Needle Biopsies: Results from a Large Canadian Cohort.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology and Infectious Diseases, Université de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4,. Electronic address:

Background: Rates of infection following ultrasound-guided transrectal prostate needle biopsy (TRUSPB) are increasing. We aimed to evaluate the effectiveness of fosfomycin tromethamine (FMT) prophylaxis in preventing post-TRUSPB infectious complications.

Methods: This nested case-control study included patients who underwent TRUSPB in a Canadian tertiary care hospital, and developed post-TRUSPB bacteremia or urinary tract infections. Read More

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December 2018

Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Histology and Embryology, Medical Faculty, Akdeniz University, 07070, Antalya, Turkey. Electronic address:

Objective: The mammalian target of rapamycin (mTOR) signaling pathway has newly been recommended to be a nutrient sensor in the placenta. It is speculated that mTORC1 may be activated in diabetes, associated with increased placental nutrient availability. Thus, we aimed to investigate the mTOR signaling pathway both in diabetic and non-diabetic placenta and searched for the alterations of angiogenic factors VEGF, VEGFR1 and VEGFR2. Read More

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December 2018

Reduction of cerebral blood flow in community-based adults with subclinical cerebrovascular atherosclerosis: A 3.0T magnetic resonance imaging study.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China. Electronic address:

Reduction in cerebral blood flow (CBF), one of the major metrics for cerebral perfusion, is associated with many brain disorders. Therefore, early characterization of CBF prior to occurrence of symptoms is essential for prevention of cerebral ischemic disorders. We hypothesized that large artery atherosclerosis might be a potential indicator for decline in cerebral perfusion. Read More

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December 2018
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PF CAT Outcomes in Diabetic Lumbar Spine Surgical Patients.

Spine J 2018 Dec 12. Epub 2018 Dec 12.

University of Utah Department of Orthopaedic Surgery, 590 Wakara Way, Salt Lake City, UT 84108. Electronic address:

Background Context: Diabetes is a highly prevalent comorbid condition among patients undergoing spine surgery. Several studies have used legacy patient-reported outcome measures to implicate diabetes as a predictor of increased disability, pain, and decreased physical function and quality of life following spine surgery. The effect of diabetes on postoperative physical function has not yet been studied using the PROMIS Physical Function Computer Adaptive Test (PF CAT). Read More

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December 2018

Glucocorticoid receptor (NR3C1) gene polymorphisms are associated with age and blood parameters in Polish Caucasian nonagenarians and centenarians.

Exp Gerontol 2018 Dec 12. Epub 2018 Dec 12.

Mossakowski Medical Research Centre, PAS, Pawinskiego 5, 02-106 Warsaw, Poland; Medical Centre of Postgraduate Education, Marymoncka 99/103, 01-813 Warsaw, Poland. Electronic address:

Introduction: Polymorphism of the glucocorticoid receptor gene (NR3C1) may modify protein abundance or function and therefore disturb human homeostasis.

Methods: Variant frequencies of the three NR3C1 polymorphisms, rs2963154, rs10515522 and rs2918418, selected in silico as associated with longevity, was analyzed in 552 DNA samples from 95 to 106-year-old individuals and in 284 samples of cord blood DNA from newborns.

Results: Frequencies of the TT genotypes of rs2963154 and rs10515522, and of the rs291841 CC genotype, were higher in the long-lived study subjects (p = 0. Read More

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December 2018

Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis.

Ann Phys Rehabil Med 2018 Dec 13. Epub 2018 Dec 13.

576104 Manipal, Karnataka, India. Electronic address:

Background: Insulin resistance is a determining factor in the pathophysiology of type 2 diabetes mellitus (T2DM). Exercise is known to improve insulin resistance, but a systematic review of the literature is lacking.

Objective: This systematic review and meta-analysis focused on identifying evidence for the effectiveness of a structured exercise intervention program for insulin resistance in T2DM. Read More

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December 2018

Tear Inflammatory Cytokines Analysis and Clinical Correlations in Diabetes and Non-diabetes with Dry Eye.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, 100191, China. Electronic address:

Purpose: To enhance the understanding of dry eye (DE) in diabetes by evaluating the ocular surface characteristics and the levels of tear inflammatory cytokines.

Design: Cross-sectional study.

Methods: Subjects were divided into four groups: 32 patients in diabetes with DE group; 24 patients in diabetes without DE group; 28 patients in non-diabetes with DE group and 29 volunteers in normal group. Read More

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December 2018

Sexual dysfunction factors in patients with schizophrenia treated with second generation antipsychotics: not only prolactin.

Actas Esp Psiquiatr 2018 Nov 1;46(6):217-25. Epub 2018 Nov 1.

Unidad de Gestión Clínica de Salud Mental. Hospital Universitario de Valme. Sevilla. España.

Introduction: Despite the high prevalence of sexual dysfunction in patients with schizophrenia, its origins are still unclear.

The Aim Of This Study: to determine the prevalence and causal factors of sexual dysfunction in a group of outpatients with schizophrenia.

Methods: The study was designed to be cross-sectional and naturalistic, including outpatients with schizophrenia undergoing second generation antipsychotic monotherapy. Read More

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November 2018

A comparative effectiveness study of degludec and insulin glargine 300U/mL in insulin-naïve patients with type 2 diabetes.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Clinical Research, Endocrine and Metabolic Consultants, Rockville, MD, USA.

Aims: To compare the real-world effectiveness of insulin degludec (degludec) and glargine 300 units/mL (glargine U300) in insulin-naïve adult patients with type 2 diabetes in routine US clinical practice.

Materials And Methods: CONFIRM is a non-interventional comparative effectiveness study following US patients across the continuum of care, through electronic medical records from multiple health systems and integrated delivery networks. Propensity-score matching controlled for confounding. Read More

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December 2018
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Comparative effectiveness and harms of long-acting insulins for Type 1 and Type 2 diabetes: a systematic review and meta-analysis.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Pacific Northwest Evidence-based Practice Center Oregon Health & Science University, Portland, Oregon.

Aims: To review evidence comparing benefits and harms of long-acting insulins in Type 1 and 2 diabetes.

Methods: MEDLINE and two Cochrane databases were searched through February 2018. Two authors selected studies meeting inclusion criteria and assessed their quality. Read More

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December 2018

Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen, Tuebingen, Germany.

Aim: Pharmacologic administration of insulin as nasal spray in humans has demonstrated a modulation of endogenous glucose production via the brain when systemic insulin levels are high. Results are conflicting under fasting insulin concentrations. To evaluate effects of brain insulin on endogenous glucose production in fasting humans with focus on hepatic glucose release, we performed a randomized, placebo controlled, blinded, cross-over experiment. Read More

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December 2018
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Healthcare staff's evaluation of a walk-in centre at a healthcare centre in an immigrant-dense area.

J Clin Nurs 2018 Dec 15. Epub 2018 Dec 15.

Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

Aims And Objectives: To evaluate a walk-in centre at a healthcare centre in an immigrant-dense area where a high proportion of the patients have limited language ability in Swedish, from the perspective of healthcare personnel.

Background: Increased global migration results in higher vulnerability in migrants, with the risk of increased morbidity and mortality. Migrants' health often deteriorates, which can be attributed to an increased level of stress and adaptation to a new lifestyle. Read More

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December 2018

Remission of hyperglycemia in spontaneously diabetic NOD mice upon transplant of microencapsulated human umbilical cord Wharton jelly-derived mesenchymal stem cells (hUCMS).

Xenotransplantation 2018 Dec 15:e12476. Epub 2018 Dec 15.

Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology, and Laboratory for Endocrine Cell Transplants and Biohybrid Organs, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Our previous in vitro demonstration of the immunoregulatory effects of microencapsulated hUCMS on human peripheral blood mononuclear cells (PBMCs) extracted from patients with recent onset, type 1 diabetes mellitus (DM), prompted us to test our product for xenograft (TX) in non obese diabetic (NOD) mice with spontaneous DM.

Methods: We transplanted microencapsulated hUCMS into the peritoneal cavity of NOD mice with either severe or mild DM. Blood glucose (BG) levels were monitored following TX, in either basal or upon glucose stimulation. Read More

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December 2018

Variability in sleep disturbance, physical activity and quality of life according to level of depressive symptoms in women with Type 2 diabetes.

Diabet Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Social Sciences and Health Policy, Wake Forest School of Medicine.

Aims: To examine (1) the prevalence of depressive symptoms in women with Type 2 diabetes, (2) the associations between depressive symptoms and the following dependent variables: sleep disturbance; physical activity; physical health-related; and global quality of life, and (3) the potential moderating effects of antidepressants and optimism on the relationship between depressive symptoms and dependent variables.

Methods: Participants in the Women's Health Initiative who had Type 2 diabetes and data on depressive symptoms (N=8895) were included in the analyses. In multivariable linear regression models controlling for sociodemographic, medical and psychosocial covariates, we examined the main effect of depressive symptoms, as well as the interactions between depressive symptoms and antidepressant use, and between depressive symptoms and optimism, on sleep disturbance, physical activity, physical health-related quality of life and global quality of life. Read More

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December 2018
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Depressive symptoms and cerebral microvascular disease in adults with Type 1 diabetes mellitus.

Diabet Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Aim: To assess the prevalence of and risk factors for depressive symptoms, comparing a sample of middle-aged adults with and without juvenile-onset Type 1 diabetes mellitus, and to determine if depressive symptoms were associated with white matter hyperintensity volume among those with Type 1 diabetes.

Methods: Depressive symptoms and white matter hyperintensities were compared between adults (age range 30-65 years) with juvenile-onset Type 1 diabetes (n=130) and adults without Type 1 diabetes (n=133). The association of Type 1 diabetes with depression was computed before and after adjustment for white matter hyperintensities. Read More

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December 2018

The apparent low incidence of paediatric Type 2 diabetes in the Republic of Ireland is multifactorial.

Diabet Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Paediatrics, Midland Regional Hospital, Mullingar, Co. Westmeath.

We read with interest the study by Candler et al. [1], evaluating the incidence of paediatric Type 2 diabetes mellitus in the UK and Republic of Ireland. They identified an overall incidence in UK children of 0. Read More

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December 2018

Blood pressure reactivity at onset of mental stress determines sympathetic vascular response in young adults.

Physiol Rep 2018 Dec;6(24):e13944

School of Medicine, Western Sydney University, Sydney, New South Wales, Australia.

We have previously shown in young males that the rate of rise in blood pressure (BP) at the onset of mental stress determines whether or not muscle sympathetic nerve activity (MSNA) has a role in driving the pressor response. The aim of this study was to investigate these interactions in young females. BP and MSNA were recorded continuously in 19 females and 21 males during 2-min mental stressors (mental arithmetic and Stroop test). Read More

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December 2018

Efficacy of Mindfulness-Based Stress Reduction in Emerging Adults with Poorly Controlled, Type 1 Diabetes: A Pilot Randomized Controlled Trial.

Pediatr Diabetes 2018 Dec 15. Epub 2018 Dec 15.

Center for Mind-Body Research, Johns Hopkins University, Baltimore, MD.

Background And Objective: The negative effects of stress on persons with type 1 diabetes (T1D) are well-established, but effective interventions to reduce stress among emerging adults with T1D are limited. The study objective was to conduct a pilot randomized controlled trial (RCT) to obtain preliminary data on the efficacy of mindfulness-based stress reduction (MBSR) to reduce stress and improve diabetes health outcomes in a population of high-risk, urban emerging adults with poorly controlled diabetes METHODS: 48 participants aged 16-20 years of age with T1D (mean duration= 8 years) were randomly assigned to one of three conditions: MSBR, cognitive-behavioral stress management (CBSM), or a diabetes support group. Data were collected at baseline, end of treatment and three months after treatment completion. Read More

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December 2018

Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, 130021, China.

Homeostasis imbalance of selenium (Se) in diabetes has received great attention. This study investigated serum and urinary Se levels in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 1 diabetes (T1D), and type 2 diabetes (T2D) in Northeast Chinese populations. From January 2010 to October 2011, patients with IFG (n = 12), IGT (n = 15), T1D (n = 25), T2D (n = 137), and healthy controls (n = 50) were enrolled in the First Hospital of Jilin University. Read More

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December 2018

Out-of-home informal support important for medication adherence, diabetes distress, hemoglobin A1c among adults with type 2 diabetes.

J Behav Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.

Adults with type 2 diabetes mellitus (T2DM) often receive self-management support from adult children, siblings or close friends residing outside of their home. However, the role of out-of-home support in patients' self-management and well-being is unclear. Patients (N = 313) with HbA1c > 7. Read More

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December 2018
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Heller myotomy is the optimal index procedure for esophageal achalasia in adolescents and young adults.

Surg Endosc 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

Background: There is limited and conflicting data on the optimal intervention for the treatment of achalasia in adolescents and young adults (AYA), Heller myotomy (HM), esophageal dilation (ED) or botulinum toxin injection (botox). The goal of this study is to determine the most appropriate index intervention for achalasia in the AYA population.

Methods: We completed a longitudinal, population-based analysis of the California (2005-2010) and New York (1999-2014) statewide databases. Read More

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December 2018

Development and validation of a simple LC-MS/MS method for the simultaneous quantitative determination of trimethylamine-N-oxide and branched chain amino acids in human serum.

Anal Bioanal Chem 2018 Dec 15. Epub 2018 Dec 15.

School of Science, Edith Cowan University, Joondalup, WA, 6027, Australia.

Serum branched chain amino acids and trimethylamine-N-oxide are monitored as potential indicators of diabetes and cardiovascular health respectively. A rapid method for their simultaneous determination using liquid chromatography and tandem mass spectrometry is described here. Branched chain amino acids and trimethylamine-N-oxide were quantified based on their specific MS/MS fragments using a selected reaction monitoring approach. Read More

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December 2018

Determinants of pulse pressure amplification in hypertensive and diabetic patients.

Hypertens Res 2018 Dec 14. Epub 2018 Dec 14.

Paris-Descartes University; Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention Unit, Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Hypertensive diabetic patients remain at high cardiovascular risk despite adequate blood pressure and glycemic control. Pulse pressure amplification (PPA) is expressed as the peripheral-to-central PP ratio and provides complementary information for use in assessing cardiovascular risk. The aim of our study was to determine the clinical and biological determinants of PPA in hypertensive and diabetic patients. Read More

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December 2018

Relieving ER stress to target NASH-driven hepatocellular carcinoma.

Nat Rev Endocrinol 2018 Dec 14. Epub 2018 Dec 14.

Division of Diabetes & Metabolism, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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December 2018

Connectivity of the Superficial Muscles of the Human Perineum: A Diffusion Tensor Imaging-Based Global Tractography Study.

Sci Rep 2018 Dec 14;8(1):17867. Epub 2018 Dec 14.

Department of Bioengineering, Medicine & Radiology, University of California, San Diego, CA, USA.

Despite the importance of pelvic floor muscles, significant controversy still exists about the true structural details of these muscles. We provide an objective analysis of the architecture and orientation of the superficial muscles of the perineum using a novel approach. Magnetic Resonance Diffusion Tensor Images (MR-DTI) were acquired in 10 healthy asymptomatic nulliparous women, and 4 healthy males. Read More

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December 2018
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Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet.

Sci Rep 2018 Dec 14;8(1):17863. Epub 2018 Dec 14.

The Rowett Institute, University of Aberdeen, Aberdeen, UK.

Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy. Affected individuals almost completely lack adipose tissue and suffer from severe diabetes and metabolic complications. Likewise, mice lacking Bscl2 in all tissues have dramatically reduced adipose mass, glucose intolerance and hyperinsulinaemia. Read More

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December 2018

Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product.

Sci Rep 2018 Dec 14;8(1):17864. Epub 2018 Dec 14.

Pediatric Endocrinology group, (Girona Biomedical Research Institute) IDIBGI, Girona, Spain.

Although alkaline phosphatase (ALP) correlates with cardiovascular risk in adults, there are no studies in children. We evaluated the association between serum ALP levels, calcium-phosphorus product (Ca*P) and cardiovascular risk markers in healthy children. Children aged 7. Read More

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December 2018
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Identification of the salusin-β receptor using proteoliposomes embedded with endogenous membrane proteins.

Sci Rep 2018 Dec 14;8(1):17865. Epub 2018 Dec 14.

Protosera Inc., 4-3-22 Nishinakajima, Yodogawa-ku, Osaka, 532-0011, Japan.

Although orphan G protein-coupled receptors (GPCRs) have been used as targets to discover unidentified natural ligands, increasing numbers of non-GPCRs have been found to mediate important biological functions. Bioinformatics of genome and cDNA resources predict putative bioactive peptides, demanding an alternative approach to efficiently unravel cell surface targets. In silico analysis of a full-length cDNA library previously allowed us to identify salusin-β, a parasympathomimetic/pro-atherosclerotic peptide with unique physicochemical properties. Read More

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December 2018

Injury factors alter miRNAs profiles of exosomes derived from islets and circulation.

Aging (Albany NY) 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Islets damage is a major abnormality underling diabetes. Recent studies suggested the value of exosomes in diagnosis. This study aimed to investigate the impact of injury factors on the miRNA profiles of islet exosomes and determine whether circulating exosomal miRNAs is suitable as biomarkers of islets damage. Read More

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December 2018

Empagliflozin, an SGLT2 inhibitor, reduced the mortality rate after acute myocardial infarction with modification of cardiac metabolomes and anti-oxidants in diabetic rats.

J Pharmacol Exp Ther 2018 Dec 14. Epub 2018 Dec 14.

Sapporo Medical University

Background: Mechanism by which sodium glucose cotransporter 2 (SGLT2) inhibitors reduce cardiac events in diabetic patients remains unclear. Here we examined effects of an SGLT2 inhibitor on the acute survival rate after myocardial infarction (MI) in an animal model of type 2 diabetes mellitus (DM) and possible involvement of modification of cardiac metabolomes and anti-oxidative proteins.

Methods And Results: MI was induced in DM rats (OLETF) and control rats (LETO). Read More

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December 2018

Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function.

J Lipid Res 2018 Dec 14. Epub 2018 Dec 14.

Nanjing Agricultural University, China

In obesity and diabetes, intramuscular fat (IMF) content correlates markedly with insulin sensitivity, which makes IMF manipulation an area of therapeutic interest. Melatonin, an important circadian rhythm-regulating hormone, reportedly regulates fat deposition, but its effects on different types of adipose vary. Little is known about the role of melatonin in IMF deposition. Read More

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December 2018

Supported self-management for people with type 2 diabetes: a meta-review of quantitative systematic reviews.

BMJ Open 2018 Dec 14;8(12):e024262. Epub 2018 Dec 14.

Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

Objectives: Self-management support aims to give people with chronic disease confidence to actively manage their disease, in partnership with their healthcare provider. A meta-review can inform policy-makers and healthcare managers about the effectiveness of self-management support strategies for people with type 2 diabetes, and which interventions work best and for whom.

Design: A meta-review of systematic reviews of randomised controlled trials (RCTs) was performed adapting Cochrane methodology. Read More

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December 2018

Informed shared decision-making programme for patients with type 2 diabetes in primary care: cluster randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e024004. Epub 2018 Dec 14.

Health Sciences and Education, University of Hamburg, Hamburg, Germany.

Objective: To translate an informed shared decision-making programme (ISDM-P) for patients with type 2 diabetes from a specialised diabetes centre to the primary care setting.

Design: Patient-blinded, two-arm multicentre, cluster randomised controlled trial of 6 months follow-up; concealed randomisation of practices after patient recruitment and acquisition of baseline data.

Setting: 22 general practices providing care according to the German Disease Management Programme (DMP) for type 2 diabetes. Read More

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December 2018

Survival and new-onset morbidity after critical care admission for acute pancreatitis in Scotland: a national electronic healthcare record linkage cohort study.

BMJ Open 2018 Dec 14;8(12):e023853. Epub 2018 Dec 14.

Surgery, School of Medicine, University of Edinburgh, Edinburgh, UK.

Introduction: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival.

Objective: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP.

Design: Cohort study. Read More

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December 2018

Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with a extract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity.

BMJ Open 2018 Dec 14;8(12):e022195. Epub 2018 Dec 14.

Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia.

Introduction: Hyperlipidaemia, hyperglycaemia and chronic inflammation are risk factors for chronic diseases cardiovascular disease and type 2 diabetes. Polyphenols are bioactive compounds found in marine algae with potential antihyperlipidaemic, antihyperglycaemic and anti-inflammatory effects. The modulation of these risk factors using bioactive polyphenols may represent a useful strategy for disease prevention and management; research in humans, however, remains limited. Read More

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December 2018
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Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: a cross-sectional study.

BMJ Open 2018 Dec 14;8(12):e020759. Epub 2018 Dec 14.

Center of Biotechnology, Khalifa University, Abu Dhabi, United Arab Emirates.

Objectives: Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated. The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD.

Research Design And Methods: Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained. Read More

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December 2018

Indigenous health worker support for patients with poorly controlled type 2 diabetes: study protocol for a cluster randomised controlled trial of the Mana Tū programme.

BMJ Open 2018 Dec 14;8(12):e019572. Epub 2018 Dec 14.

Te Kupenga Hauora Māori, University of Auckland, Auckland, New Zealand.

Introduction: Type 2 diabetes mellitus (T2DM) and its complications are more common among Māori and Pacific people compared with other ethnic groups in New Zealand. Comprehensive and sustained approaches that address social determinants of health are required to address this condition, including culturally specific interventions. Currently, New Zealand has no comprehensive T2DM management programme for Māori or Pacific people. Read More

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December 2018

Aging of Antiviral CD8 Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing.

J Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045;

Aging of established antiviral T cell memory can foster a series of progressive adaptations that paradoxically improve rather than compromise protective CD8 T cell immunity. We now provide evidence that this gradual evolution, the pace of which is contingent on the precise context of the primary response, also impinges on the molecular mechanisms that regulate CD8 memory T cell (T) homeostasis. Over time, CD8 T generated in the wake of an acute infection with the natural murine pathogen lymphocytic choriomeningitis virus become more resistant to apoptosis and acquire enhanced cytokine responsiveness without adjusting their homeostatic proliferation rates; concurrent metabolic adaptations promote increased CD8 T quiescence and fitness but also impart the reacquisition of a partial effector-like metabolic profile; and a gradual redistribution of aging CD8 T from blood and nonlymphoid tissues to lymphatic organs results in CD8 T accumulations in bone marrow, splenic white pulp, and, particularly, lymph nodes. Read More

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December 2018

Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset.

Diabetes Care 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN

Objective: This study investigated the temporal dynamics of pancreas volume and microstructure in children and adolescents with recent-onset type 1 diabetes (T1D) and individuals without diabetes, including a subset expressing autoantibodies associated with the early stages of T1D.

Research Design And Methods: MRI was performed in individuals with recent-onset stage 3 T1D ( = 51; median age 13 years) within 100 days after diagnosis (mean 67 days), 6 months, and 1 year postdiagnosis. Longitudinal MRI measurements were also made in similarly aged control participants ( = 57) and in autoantibody-positive individuals without diabetes ( = 20). Read More

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December 2018
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Impaired Sensitivity to Thyroid Hormones Is Associated With Diabetes and Metabolic Syndrome.

Diabetes Care 2018 Dec 14. Epub 2018 Dec 14.

Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Universidad de Zaragoza, Zaragoza, Spain.

Objective: Diabetes prevalence and incidence increase among individuals with hypothyroidism but also among those with hyperthyroxinemia, which seems contradictory. Both high free thyroxine (fT4) and high thyroid-stimulating hormone (TSH) are present in the resistance to thyroid hormone syndrome. A mild acquired resistance to thyroid hormone might occur in the general population and be associated with diabetes. Read More

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December 2018
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Youth With Type 1 Diabetes Taking Responsibility for Self-Management: The Importance of Executive Functioning in Achieving Glycemic Control: Results From the Longitudinal DINO Study.

Diabetes Care 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Psychology, VU University Medical Center, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.

Objective: Successful self-management of type 1 diabetes requires cognitive skills such as executive functioning (EF). In the transition to adolescence, youth take over responsibility for diabetes management. We set out to test: ) the association between EF and glycemic control over time and ) whether this association was moderated: ) by youth, shared, or parent responsibility for diabetes management and ) youth's age. Read More

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December 2018

Clinical and MRI Features of Cerebral Small-Vessel Disease in Type 1 Diabetes.

Diabetes Care 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Karolinska University Hospital, and Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

Objective: To assess the prevalence of cerebral small-vessel disease (SVD) in subjects with type 1 diabetes compared with healthy control subjects and to characterize the diabetes-related factors associated with SVD.

Research Design And Methods: This substudy was cross-sectional in design and included 191 participants with type 1 diabetes and median age 40.0 years (interquartile range 33. Read More

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December 2018

Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes.

Diabetes Care 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL.

Objective: Pancreas size is reduced in patients at type 1 diabetes onset and in autoantibody (AAB)-positive donors without diabetes. We sought to determine whether pancreas volume (PV) imaging could improve understanding of the loss of pancreas size in first-degree relatives (FDRs) of patients with type 1 diabetes. We also examined relationships among PV, AAB status, and endocrine and exocrine functions. Read More

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December 2018

Circulating Exosomal miR-20b-5p is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle.

Diabetes 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Pharmacology Karolinska Institutet, SE-171 77 Stockholm, Sweden,

MicroRNAs (miRNAs) are noncoding RNAs representing an important class of gene expression modulators. Extracellular circulating miRNAs are both candidate biomarkers for disease pathogenesis and mediators of cell-to-cell communication. We examined the miRNA expression profile of total serum and serum derived exosome-enriched extracellular vesicles in people with normal glucose tolerance or type 2 diabetes. Read More

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December 2018

Low Level Insulin Content Within Abundant Non-Beta Islet Endocrine Cells in Long-Standing Type 1 Diabetes.

Diabetes 2018 Dec 14. Epub 2018 Dec 14.

McNair Medical Institute, Baylor College of Medicine, Houston, TX, 77030

Although most type 1 diabetes (T1D) patients continue to produce small amounts of insulin decades after disease onset, very few β-cells persist within their pancreata. Consequently, the source of persistent insulin secretion within T1D remains unclear. We hypothesized low-level insulin content within non-β-cells could underlie persistent T1D insulin secretion. Read More

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December 2018

Genetic Nicotinamide N-Methyltransferase () Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance.

Diabetes 2018 Dec 14. Epub 2018 Dec 14.

Sanofi Research and Development, Industriepark Hoechst, H823, D-64926 Frankfurt am Main, Germany.

Antisense oligonucleotide knockdown (ASO-KD) of nicotinamide N-methyltransferase (NNMT) in high-fat diet (HFD)-fed mice has been reported to reduce weight gain, plasma insulin and improve glucose tolerance. Using NNMT-ASO-KD or NNMT knockout mice (NNMT), we tested the hypothesis that deletion protects against diet-induced obesity and its metabolic consequences in males and females on obesity-inducing diets. We also examined samples from a human weight reduction (WR) study for adipose (a) expression and plasma 1-methylnicotinamide (MNAM) levels. Read More

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December 2018

A genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in on Chromosome 12q13.13 Associated with Susceptibility to Fulminant Type 1 Diabetes.

Diabetes 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka, Japan

The first genome-wide association study of fulminant type 1 diabetes mellitus was performed in Japanese individuals. As previously reported using a candidate gene approach, a strong association was observed with multiple SNPs in the HLA region, and the strongest association was observed with rs9268853 in the class II DR region (P=1.56 x 10, odds ratio [OR] 3. Read More

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December 2018
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