665,410 results match your criteria Diabetes Metabolic Syndrome and Obesity: Targets and Therapy [Journal]


Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.

Neuropsychopharmacology 2019 Apr 19. Epub 2019 Apr 19.

Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.

Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition toward rapid unplanned reactions to stimuli, is one of the multifaceted determinants underlying the etiology of dysregulated eating and its evolving pathogenesis. The medial prefrontal cortex (mPFC) is a major neural director of reward-driven behavior and impulsivity. Read More

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http://dx.doi.org/10.1038/s41386-019-0394-8DOI Listing

Population density is beneficially associated with 12-year diabetes risk marker change among residents of lower socio-economic neighborhoods.

Health Place 2019 Apr 16;57:74-81. Epub 2019 Apr 16.

Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia; Swinburne University of Technology, John Street, Hawthorne, VIC 3122, Hawthorn, Australia.

We examined associations of neighborhood population density with 12-year changes in diabetes risk (post-challenge plasma glucose), and potential moderation by neighborhood socio-economic status (SES) among 4,816 Australians. In lower SES neighborhoods, post-challenge plasma glucose increased by 6% in low-density, remained stable in medium-density and decreased by 3% in high-density neighborhoods. In medium SES neighborhoods, glucose remained stable in high-density, but increased by 2% and 3% in medium- and low-density neighborhoods, respectively. Read More

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http://dx.doi.org/10.1016/j.healthplace.2019.02.006DOI Listing

Calcaneal tuberosity fractures through prior Schantz pin sites in patients with diabetic neuropathy.

Foot (Edinb) 2019 Mar 2;39:96-99. Epub 2019 Mar 2.

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, United States.

Schantz pin placement in the calcaneal tuberosity is a common procedure known to be complicated by pin site infections and nerve injuries. Fractures through Schantz pin sites has been reported mostly in diaphyseal bone. This case series highlights three patients with type 2 diabetes mellitus and diabetic neuropathy who were fixed in an external fixator frame with a pin through the calcaneal tuberosity. Read More

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http://dx.doi.org/10.1016/j.foot.2019.02.011DOI Listing

Association between sarcopenia and diabetes in community dwelling elderly in the Amazon region - Viver Mais Project.

Arch Gerontol Geriatr 2019 Mar 27;83:121-125. Epub 2019 Mar 27.

State University Of Pará, Brazil; Hospital Cynthia Charone, Brazil.

Background: Studies indicate the intrinsic relationship between sarcopenia and diabetes mellitus (DM) pathophysiological mechanisms. Changes in insulin and muscular metabolism are features of diabetic patients and can interact as sarcopenic accelerators. Conversely, sarcopenic patients feature lower glucose tolerance and higher serum insulin levels, predisposing them to DM. Read More

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http://dx.doi.org/10.1016/j.archger.2019.03.020DOI Listing

Achievement of low density lipoprotein (LDL) cholesterol targets in primary and secondary prevention: Analysis of a large real practice database in Italy.

Atherosclerosis 2019 Apr 8;285:40-48. Epub 2019 Apr 8.

Hypertension Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, Rome, Italy; IRCCS Neuromed, Pozzilli, IS, Italy. Electronic address:

Background And Aims: Target and intensity of low-density lipoprotein cholesterol (LDL-C) lowering therapy should be tailored according to the individual global cardiovascular (CV) risk. We aimed at retrospectively evaluating real-life LDL-C goal attainment and predictive factors for predefined LDL-C therapeutic goals both in primary and secondary prevention.

Methods: We collected data from a large cohort of outpatients aged 40-65 years, followed by general practitioners, cardiologists and diabetologists in Italy. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.017DOI Listing

Red blood cell membrane cholesterol in type 2 diabetes mellitus.

Thromb Res 2019 Apr 7;178:91-98. Epub 2019 Apr 7.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1 Matieland, 7602, South Africa. Electronic address:

Type II diabetes mellitus (T2DM) affects an estimate of 450 million individuals. Hence, there remains an urgent need to explore the use of novel biomarkers with the aim of preventing and managing cardiovascular risk among these individuals. Hallmarks of this condition are lipid and glucose dyshomeostasis which are accompanied by a prothrombotic phenotype; these pose as eminent links between T2DM and cardiovascular disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193018
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http://dx.doi.org/10.1016/j.thromres.2019.04.005DOI Listing
April 2019
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Randomized trial evaluating the role of weight loss in overweight and obese men with early stage prostate Cancer on active surveillance: Rationale and design of the Prostate Cancer Active Lifestyle Study (PALS).

Contemp Clin Trials 2019 Apr 16. Epub 2019 Apr 16.

Fred Hutchinson Cancer Research Center, United States; Veterans Affairs Puget Sound Health Care System, United States; University of Washington, United States.

Active surveillance (AS) is increasingly used to monitor patients with low-risk prostate cancer; however, approximately 50% of AS patients experience disease reclassification requiring definitive treatment and little is known about patient characteristics that modify the risk of reclassification. Obesity may be one of the major contributing factors. The Prostate Cancer Active Lifestyle Study (PALS) is a clinical trial evaluating the impact of weight loss among overweight/obese (Body Mass Index (BMI) ≥ 25 kg/m) men with clinically localized prostate cancer on AS. Read More

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http://dx.doi.org/10.1016/j.cct.2019.04.004DOI Listing

Role of AMPK and its molecular intermediates in subjugating cancer survival mechanism.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, China.

The gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are caused by an abrupt energy imbalance. As an energy sensor, AMP-activated kinase (AMPK) can regulate the cellular energy status. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.039DOI Listing

RTN1-C is involved in high glucose-aggravated neuronal cell subjected to oxygen-glucose deprivation and reoxygenation injury via endoplasmic reticulum stress.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. Electronic address:

Background: Patients suffering from diabetes mellitus experience poor outcomes after ischemic stroke. RTN1-C, ER-associated proteins localized in endoplasmic reticulum (ER) membrane, plays an important role in ER stress-induced apoptosis and regulates cellular susceptibility to different apoptosis pathways. Overexpression of RTN1-C can aggravate cerebral ischemia/reperfusion injury (IRI). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.010DOI Listing

GLP-1: Molecular mechanisms and outcomes of a complex signaling system.

Neurochem Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Meal ingestion provokes the release of hormones and transmitters, which in turn regulate energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01970186193009
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http://dx.doi.org/10.1016/j.neuint.2019.04.010DOI Listing
April 2019
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Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status.

Physiol Behav 2019 Apr 16. Epub 2019 Apr 16.

Center for Health and Community, Department of Psychiatry, UCSF, United States; Department of Medicine, Division of Cardiology, UCSF, United States. Electronic address:

In general, glucose consumption improves cognitive performance; however, it is unknown whether glucose specifically enhances attentional food bias, and how this process may vary by BMI status. We hypothesized that glucose consumption would increase attentional food bias among individuals of obese BMI status more so than among individuals of lean BMI status. Participants (N = 35) completed the n-back, a working memory task modified to assess attentional food bias (ATT-Food), under fasting and glucose challenge conditions. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.04.014DOI Listing

Pregabalin affords retinal neuroprotection in diabetic rats: Suppression of retinal glutamate, microglia cell expression and apoptotic cell death.

Exp Eye Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology and Toxicology, Faculty of Pharmacy (girls), Al-Azhar University, Cairo, Egypt.

Pregabalin is the first drug to receive FDA approval for treating diabetic neuropathic pain. This study investigated the neuroprotective effect of pregabalin in an experimental model of diabetic retinopathy and tested some possible mechanisms underlying the putative neuroprotective effect. Male Wistar rats received streptozotocin (45 mg/kg) to induce type 1 diabetes mellitus. Read More

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http://dx.doi.org/10.1016/j.exer.2019.04.014DOI Listing

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.

Cell 2019 Apr;177(3):597-607.e9

University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address:

The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their associations with body mass index (BMI) and obesity-related cardiometabolic diseases. Read More

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http://dx.doi.org/10.1016/j.cell.2019.03.044DOI Listing

Ginsenoside Rg1 attenuates hepatic insulin resistance induced by high-fat and high-sugar by inhibiting inflammation.

Eur J Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan, 650500, PR China; Yunnan Province Key Laboratory for Nutrition and Food Safety in Universities, PR China. Electronic address:

Ginsenoside Rg1 is the active ingredient of Chinese herbal medicine ginseng and sanqi, which has remarkable effects on anti-inflammation and anti-diabetes. In this study, we explored the molecular mechanism of ginsenoside Rg1 against diabetes in rat subjected to insulin resistance induced by high-fat and high-sugar (HFHS). Biochemical analysis revealed that ginsenoside Rg1 significantly decreased the serum levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, total cholesterol, triglyceride, low-density lipoprotein and increased the serum levels of high-density lipoprotein, which indicated ginsenoside Rg1 improved the extent of hepatic steatosis. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.027DOI Listing

Laboratory intervention to improve the request of urinary albumin in primary care patients with arterial hypertension and financial implications.

Clin Biochem 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, University of Missouri, Columbia, MO, USA.

Introduction: The request of Urinary albumin in primary care in Spain is insufficient to monitor patients with diabetes and hypertension (HTN). Our aim was to evaluate a strategy designed in consensus with general practitioners (GPs) to improve the request of urinary albumin in primary care patients with HTN according to guidelines, and to study its financial implications.

Materials And Methods: In a meeting with GPs, we decided that the Laboratory Information System (LIS) would automatically register the albumin-to-creatinine ratio (ACR) test in patients with HTN when the former had not been requested in the previous year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00099120193006
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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.012DOI Listing
April 2019
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SMFM Special Statement: State of the Science on Multifetal Gestations: Unique Considerations and Importance.

Am J Obstet Gynecol 2019 Apr 16. Epub 2019 Apr 16.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States.

We sought to review the state of the science for research on multiple gestations. A literature search was performed using PubMed to quantify the representation of multiple gestations for a sample period (2012-2016) limited to Phase III and IV randomized controlled trials and written in English addressing at least one of four major pregnancy complications for illustration: fetal growth restriction or small-for-gestational-age fetus, gestational diabetes, preeclampsia, and preterm delivery. Of the 226 studies included in the analysis, multiple pregnancies were most represented in studies of preterm delivery: 17% of trials recruited both singleton and multiple pregnancies, and another 18% of trials recruited only multiple pregnancies. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.04.013DOI Listing

Chemerin and Dermcidin in Human Milk and Their Alteration in Gestational Diabetes.

J Hum Lact 2019 Apr 19:890334419837523. Epub 2019 Apr 19.

5 Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Medical School, Firat University, Elazig, Turkey.

Background: Chemerin and dermcidin, which have antimicrobial properties, are molecules that are also related to insulin resistance and inflammation.

Research Aims: The aims were to determine the amounts of chemerin and dermcidin in the milk and blood of mothers with gestational diabetes, and to compare the amounts of chemerin and dermcidin in the milk and blood of mothers with and without diabetes.

Methods: This was a two-group nonrandomized longitudinal study with a convenience sampling of mothers without gestational diabetes ( n = 27) and mothers with gestational diabetes ( n = 26). Read More

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http://dx.doi.org/10.1177/0890334419837523DOI Listing

Risk factors for gestational diabetes: An umbrella review of meta-analyses of observational studies.

PLoS One 2019 19;14(4):e0215372. Epub 2019 Apr 19.

Cyprus International Institute for Environmental & Public Health, Cyprus University of Technology, Limassol, Cyprus.

Background/objective: Gestational diabetes mellitus (GDM) is a common pregnancy complication, with complex disease mechanisms, and several risk factors may contribute to its onset. We performed an umbrella review to summarize the evidence from meta-analyses of observational studies on risk factors associated with GDM, evaluate whether there are indications of biases in this literature and identify which of the previously reported associations are supported by convincing evidence.

Methods: We searched PubMed and ISI Web of Science from inception to December 2018 to identify meta-analyses examining associations between putative risk factors for GDM. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215372PLOS

Microsatellite instability is inversely associated with type 2 diabetes mellitus in colorectal cancer.

PLoS One 2019 19;14(4):e0215513. Epub 2019 Apr 19.

Department of Surgery, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo, Japan.

Background: Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. High-frequency MSI (MSI-H) colorectal cancers (CRCs) are known to have different clinicopathological features compared with microsatellite stable (MSS) CRCs. In addition, previous studies have shown that type2 diabetes mellitus (T2DM) is a risk factor for malignant tumors including CRCs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215513PLOS
April 2019
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IgM antibodies against phosphorylcholine measured early after acute ST-elevation myocardial infarction in relation to atherosclerotic disease burden and long-term clinical outcome.

PLoS One 2019 19;14(4):e0215640. Epub 2019 Apr 19.

Department of Cardiology, Oslo University Hospital, Oslo, Norway.

Purpose: Studies have reported an association between low levels of natural immunoglobulin M antibodies against phosphorylcholine(IgM anti-PC) and worse prognosis in patients with coronary artery disease (CAD). The aims of the present study were, in patients with ST-elevation myocardial infarction (STEMI); 1) to compare serum levels of IgM anti-PC measured acutely and after 3 months; 2) to study an association between levels of IgM anti-PC and the severity ofCAD, and; 3) to investigate whether IgM anti-PC levels are associated with long-term clinical outcome.

Methods: A total of 213 patients without known diabetes (median age 59 years) with a PCI treated STEMI were enrolled. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215640PLOS
April 2019
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Diabetes.

Authors:
Suzanne Edison

CMAJ 2018 Oct;190(41):E1232

Seattle, Wash.

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http://dx.doi.org/10.1503/cmaj.180762DOI Listing
October 2018

Association Between Changes in Postpartum Weight and Waist Circumference and Changes in Cardiometabolic Risk Factors Among Women With Recent Gestational Diabetes.

Prev Chronic Dis 2019 Apr 18;16:E47. Epub 2019 Apr 18.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts.

Introduction: Women with gestational diabetes mellitus (GDM) have a 30% to 70% risk for developing type 2 diabetes and are at increased risk for cardiovascular disease. Little is known about how anthropometric changes in the first postpartum year modify cardiometabolic risk factors.

Methods: We randomly assigned women in the Balance After Baby study to an intervention group consisting of participation in a web-based lifestyle program or to a control group in which no program was offered. Read More

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http://dx.doi.org/10.5888/pcd16.180308DOI Listing

Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):47-50

Department of Zoology, Lahore College for Women University, Lahore, Pakistan.

Type 2 diabetes mellitus (T2DM) is the most common metabolic and multifactorial disease in which both genetic and environmental factors are involved. In diabetes, the defects in the cellular metabolism result in higher levels of free radicals. These radicals react with other vital cellular molecules, which are responsible in diabetes side effects and known as diabetic retinopathy (DR), a disease of the retina that results in impairment or loss of vision. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2019025074DOI Listing
January 2019

Myonectin deletion promotes adipose fat storage and reduces liver steatosis.

FASEB J 2019 Apr 19:fj201900520R. Epub 2019 Apr 19.

Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

We recently described myonectin (also known as erythroferrone) as a novel skeletal muscle-derived myokine with metabolic functions. Here, we use a genetic mouse model to determine myonectin's requirement for metabolic homeostasis. Female myonectin-deficient mice had larger gonadal fat pads and developed mild insulin resistance when fed a high-fat diet (HFD) and had reduced food intake during refeeding after an unfed period but were otherwise indistinguishable from wild-type littermates. Read More

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http://dx.doi.org/10.1096/fj.201900520RDOI Listing

Managing costs and care for chronic idiopathic constipation.

Authors:
Dana McCormick

Am J Manag Care 2019 Mar;25(4 Suppl):S63-S69

Director of Pharmacy, Blue Cross Blue Shield of Texas, Richardson, TX. Email:

For decades, chronic idiopathic constipation (CIC) has been one of the most common chronic functional gastrointestinal disorders encountered by clinicians. Common comorbidities include depression, diabetes, functional dyspepsia, hypothyroidism, overweight, obesity, and neurological disorders. CIC imposes a large economic burden on the American healthcare system with estimated costs of $1912 to $7522 in 2007 US dollars per patient per year. Read More

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March 2019
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Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial.

Obesity (Silver Spring) 2019 Apr 19. Epub 2019 Apr 19.

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Objective: This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes.

Methods: Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0. Read More

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http://dx.doi.org/10.1002/oby.22449DOI Listing

Free fatty acid receptor GPR120 and GPR40 are essential for oil-induced GIP secretion.

J Diabetes Investig 2019 Apr 19. Epub 2019 Apr 19.

Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University.

Aims/introduction: Incretin hormone glucose-dependent insulinotropic polypeptide / gastric inhibitory polypeptide (GIP) plays a key role in high-fat diet-induced obesity and insulin resistance. GIP is strongly secreted from enteroendocrine K cells by oil ingestion. GPR120 and GPR40 are two major receptors for long chain fatty acids and are expressed in enteroendocrine K cells. Read More

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http://dx.doi.org/10.1111/jdi.13059DOI Listing

Residual cardiovascular risk among people with diabetes.

Diabetes Obes Metab 2019 Apr;21 Suppl 1:28-38

Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Type 2 diabetes (T2D) is a growing health concern across both developed and developing countries. Cardiovascular disease (CVD) remains the major cause of increased mortality in this patient population. In recent years, effective low density lipoprotein lowering treatments and other risk reduction strategies have substantially reduced the risk of atherosclerotic CVD, yet patients with T2D continue to remain at increased risk for atherosclerotic CVD. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.13646
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http://dx.doi.org/10.1111/dom.13646DOI Listing
April 2019
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The extent to which statins have improved cardiovascular outcomes: Lessons from randomized trials and observational studies of "real world" practice in people with diabetes.

Diabetes Obes Metab 2019 Apr;21 Suppl 1:17-27

College of Public Health, Carver College of Medicine, University of Iowa, Iowa City, Iowa.

Statins are the mainstay of therapy for cardiovascular risk reduction in patients with diabetes mellitus. It is estimated that there are more than half a billion patients with diabetes mellitus worldwide and the numbers of prevalent cases of diabetes are expected to increase in both developed and developing countries in the next decade. Statins reduce risk of mortality and morbidity mainly by reducing blood low density cholesterol. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.13701
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http://dx.doi.org/10.1111/dom.13701DOI Listing
April 2019
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Efficacy and safety of proprotein convertase subtilisin/kexin 9 inhibitors in people with diabetes and dyslipidaemia.

Diabetes Obes Metab 2019 Apr;21 Suppl 1:39-51

L'institut du thorax, INSERM, CNRS, University of Nantes, CHU Nantes, Nantes, France.

Diabetic dyslipidaemia, characterized by quantitative, qualitative and kinetic changes in all major circulating lipids, contributes to the increased cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). A promising therapeutic avenue is the inhibition of the proprotein convertase subtilisin kexin 9 (PCSK9) with human monoclonal antibodies (mAbs) that potently reduce plasma low-density lipoprotein cholesterol (LDL-C) levels on top of statin treatment. The aim of this review is to evaluate the efficacy of PCSK9 inhibitors to lower the residual cardiovascular risk of T2DM patients and to discuss the safety of PCSK9 inhibition in these patients. Read More

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http://dx.doi.org/10.1111/dom.13636DOI Listing

Clinical guidance on the contemporary use of proprotein convertase subtilisin/kexin type 9 monoclonal antibodies.

Diabetes Obes Metab 2019 Apr;21 Suppl 1:52-62

School of Medicine, University of Western Australia, Perth, Australia.

There is now significant evidence for the benefits of lowering low-density lipoprotein cholesterol (LDL-c) to reduce the risk of atherosclerotic cardiovascular disease (ASCVD). Although statins are the most widely prescribed lipid-lowering therapy that effectively lower LDL-c, especially in combination with ezetimibe, some patients require adjunctive therapy to further lower LDL-c and mitigate attendant risk of ASCVD. The gap can be filled by proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies whose use is currently supported by two recent cardiovascular outcome studies and new treatment guidelines. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.13637
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http://dx.doi.org/10.1111/dom.13637DOI Listing
April 2019
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The importance of dyslipidaemia in the pathogenesis of cardiovascular disease in people with diabetes.

Diabetes Obes Metab 2019 Apr;21 Suppl 1:6-16

Department of Primary Care and Public Health, Imperial College London, London, UK.

Atherosclerotic cardiovascular events are the leading cause of mortality and morbidity in those with diabetes. A key contributor to the development of atherosclerosis in this population is the presence of a particularly atherogenic lipid profile often referred to as 'Diabetic Dyslipidemia'. This profile is characterized by elevated triglycerides, triglyceride-rich lipoproteins, small dense LDL particles, and reduced HDL levels. Read More

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http://dx.doi.org/10.1111/dom.13691DOI Listing

External Validation of a Pre-Transplant Biomarker Model (REVERSE) Predictive of Renal Recovery after Liver Transplantation.

Hepatology 2019 Apr 19. Epub 2019 Apr 19.

Baylor University Medical Center, Dallas, TX, United States.

In patients with end stage liver disease, the ability to predict recovery of renal function following liver transplantation alone (LTA) remains elusive. However, several important clinical decisions depend on whether renal dysfunction is recoverable after LTA. We used a cohort of patients undergoing LT to independently validate a pre-LT model predictive of post-LTA renal recovery (REVERSE: high osteopontin (OPN) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels, age <57, no diabetes). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30667
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http://dx.doi.org/10.1002/hep.30667DOI Listing
April 2019
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HbA1c showed a positive association with carcinoembryonic antigen (CEA) level in only diabetes, not prediabetic or normal individuals.

J Clin Lab Anal 2019 Apr 19:e22900. Epub 2019 Apr 19.

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: This study was conducted to investigate the association of carcinoembryonic antigen (CEA) and glycated hemoglobin (HbA1c) in normal, prediabetic, and diabetic subjects.

Methods: A total of 2,911 participants who underwent general health checkups were enrolled and categorized into the normal, prediabetes, and diabetes groups. Demographic, anthropological, and clinical variables were investigated, and correlations with CEA were analyzed. Read More

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http://dx.doi.org/10.1002/jcla.22900DOI Listing

Closed-loop insulin delivery in end-of-life care: a case report.

Diabet Med 2019 Apr 19. Epub 2019 Apr 19.

Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Background: Glucose management for people with diabetes approaching the end of life can be very challenging. The aim is to balance a minimally invasive approach with avoidance of symptomatic hypo- and hyperglycaemia.

Case Report: We present a case of a hospitalized individual whose glucose was managed with closed-loop insulin delivery within a randomized controlled trial setting during a period of terminal illness. Read More

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http://dx.doi.org/10.1111/dme.13974DOI Listing

Systematic review and meta-analysis of clinical trials examining the effect of hyperbaric oxygen therapy in people with diabetes-related lower limb ulcers.

Diabet Med 2019 Apr 19. Epub 2019 Apr 19.

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.

Aim: To examine the efficacy of hyperbaric oxygen therapy in healing diabetes-related lower limb ulcers through a meta-analysis of randomized clinical trials.

Methods: A literature search was conducted to identify appropriate clinical trials. Inclusion required randomized study design and reporting of the proportion of diabetes-related lower limb ulcers that healed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dme.13975
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http://dx.doi.org/10.1111/dme.13975DOI Listing
April 2019
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Use of 4β-hydroxycholesterol plasma concentrations as an endogenous biomarker of CYP3A activity: Clinical validation in individuals with type 2 diabetes.

Clin Pharmacol Ther 2019 Apr 19. Epub 2019 Apr 19.

Faculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.

The relevance of endogenous 4β-hydroxycholesterol (4β-OHC) plasma concentrations or of the 4β-OHC/total cholesterol concentration ratio (4β-OHC ratio) as surrogate markers of CYP3A activity was evaluated in individuals with (n=38) or without (n=35) type 2 diabetes (T2D). Midazolam was used as a comparator to validate exploratory measures of phenotypic CYP3A activity. Metabolic ratios (MR) of orally administered midazolam in the non-diabetic and diabetic populations correlated significantly with 4β-OHC (r =0. Read More

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http://dx.doi.org/10.1002/cpt.1472DOI Listing

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study.

JAMA Netw Open 2019 Apr 5;2(4):e192745. Epub 2019 Apr 5.

Framingham Heart Study, Framingham, Massachusetts.

Importance: Dementia risk may be attenuated by physical activity (PA); however, the specific activity levels optimal for dementia prevention are unclear. Moreover, most older adults are unable to meet the nationally recommended PA guidelines, set at 150 minutes of moderate to vigorous PA per week.

Objective: To assess the association of total steps walked per day and total dose (intensity × duration) of PA with brain volumes on magnetic resonance imaging (MRI) among Framingham Heart Study participants. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2745DOI Listing

Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia: A Pooled Analysis of More Than 1 Million Participants.

JAMA Netw Open 2019 Apr 5;2(4):e192696. Epub 2019 Apr 5.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Asia is home to the largest diabetic populations in the world. However, limited studies have quantified the association of diabetes with all-cause and cause-specific mortality in Asian populations.

Objectives: To evaluate the association of diabetes with all-cause and cause-specific mortality in Asia and to investigate potential effect modifications of the diabetes-mortality associations by participants' age, sex, education level, body mass index, and smoking status. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2696DOI Listing
April 2019
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Boronic Derivatization of Monoacylglycerol and Monitoring in Biofluids.

Anal Chem 2019 Apr 19. Epub 2019 Apr 19.

Monoacylglycerols (MAGs) are active mediators involved in multiple biological processes closely related to the pathological de-velopment of diabetes, obesity and cancers. Sensitive and unambiguous detection of MAG is thus essential; however, previous methods are both indirect and labor-intensive. Herein, we developed a straightforward approach by derivatization of MAGs with 3-nitrophenylboronic acid (3-NPB) for sensitive and selective analysis in cell lysates, tissues and serums by mass spectrometry (MS). Read More

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http://dx.doi.org/10.1021/acs.analchem.9b00805DOI Listing

Associations between fatigue, sleep disturbance and eating style in adults with type 2 diabetes: A correlational study.

J Clin Nurs 2019 Apr 19. Epub 2019 Apr 19.

College of Nursing, University of Illinois at Chicago, Chicago, IL, USA.

Aims And Objectives: To test the hypothesis that fatigue and sleep disturbance account for a significant amount of variation in eating styles among people with type 2 diabetes (T2D).

Background: Healthy eating is an important component of diabetes self-care but remains a major challenge. In people with T2D, symptoms of fatigue and sleep disturbance are pervasive. Read More

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http://dx.doi.org/10.1111/jocn.14883DOI Listing

Nutrition-related factors associated with waiting list mortality in patients with interstitial lung disease: a retrospective cohort study.

Clin Transplant 2019 Apr 19:e13566. Epub 2019 Apr 19.

Department of Metabolism and Clinical Nutrition, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto-city, Kyoto, Japan.

Japanese patients with interstitial lung disease (ILD) sometimes die waiting for lung transplantation (LTx) because it takes about 2 years to receive it in Japan. We evaluated nutrition-related factors associated with waiting list mortality. Seventy-six ILD patients were hospitalized in Kyoto University Hospital at registration for LTx from 2013 to 2015. Read More

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http://dx.doi.org/10.1111/ctr.13566DOI Listing

PET imaging during hypoglycemia to study adipose tissue metabolism.

Eur J Clin Invest 2019 Apr 19:e13120. Epub 2019 Apr 19.

Departments of Radiology and Nuclear Medicine, Nijmegen, Netherlands.

Background: Disturbances in adipose tissue glucose uptake may play a role in the pathogenesis of type 2 diabetes, yet its examination by 2-deoxy-2-[ F]fluorodeoxyglucose ([ F]FDG) PET/CT is challenged by relatively low uptake kinetics. We tested the hypothesis that performing [ F]FDG PET/CT during a hypoglycemic clamp would improve adipose tissue tracer uptake to allow specific comparison of adipose tissue glucose handling between people with or without type 2 diabetes.

Design: We enrolled participants with or without diabetes who were at least overweight, to undergo a hyperinsulinemic hypoglycemic clamp or a hyperinsulinemic euglycemic clamp (n=5 per group). Read More

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http://dx.doi.org/10.1111/eci.13120DOI Listing

VITAL study: an incomplete picture?

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3142-3147

Diabetes Research Institute (DRI) and Clinical Cell Transplant Program, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.26355/eurrev_201904_17599DOI Listing

MiR-92a contributes to the cardiovascular disease development in diabetes mellitus through NF-κB and downstream inflammatory pathways.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3070-3079

International Medical Center, Tianjin First Central Hospital, Tianjin, China.

Objective: To explore the role of microRNA-92a (miR-92a) during the development of cardiovascular disease (CAD) in diabetes mellitus (DM) patients, and to investigate its correlation with NF-κB and downstream inflammatory cytokines in diabetes mellitus-associated cardiovascular disease (DM-CAD).

Patients And Methods: Expression of miR-92a in DM and DM-CAD patients was estimated by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Receiver operating characteristic (ROC) analysis was used to estimate the capability of miR-92a to discriminate between DM-CAD and DM patients. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17589DOI Listing

Risk Factors for MERS-CoV Seropositivity among Animal Market and Slaughterhouse Workers, Abu Dhabi, United Arab Emirates, 2014-2017.

Emerg Infect Dis 2019 May;25(5):927-935

Camel contact is a recognized risk factor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Because specific camel exposures associated with MERS-CoV seropositivity are not fully understood, we investigated worker-camel interactions and MERS-CoV seroprevalence. We assessed worker seroprevalence in 2 slaughterhouses and 1 live-animal market in Abu Dhabi, United Arab Emirates, during 2014-2017 and administered an epidemiologic survey in 2016 and 2017. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-1728_article.htm
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http://dx.doi.org/10.3201/eid2505.181728DOI Listing
May 2019
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[Type 2 Diabetes Mellitus and Heart Failure: Innovative Possibilities for Management of Prognosis].

Kardiologiia 2019 Apr 17;59(4):76-87. Epub 2019 Apr 17.

Peoples Friendship University of Russia (RUDN University).

Type 2 diabetes mellitus (T2DM) has gone beyond the professional interests of one specialty. T2DM, cardiovascular (CV) diseases and chronic kidney disease, considered from the standpoint of a single cardio-reno-metabolic continuum, place a heavy economic burden on society. At the same time, the improvement of diagnostic methods and medical technologies led to distinct decrease in the frequency and mortality from a number of complications of T2DM, including myocardial infarction and stroke, but other states took their place. Read More

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https://lib.ossn.ru/jour/article/view/596
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http://dx.doi.org/10.18087/cardio.2019.4.10253DOI Listing
April 2019
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[Progression of Chronic Heart Failure: Prognostic Criteria and Non-Drug Prevention].

Kardiologiia 2019 Apr 16;59(4):26-32. Epub 2019 Apr 16.

Republic Scientific and Practical Center "Cardiology", Minsk.

Purpose: to study frequency of progression of chronic heart failure (CHF), to develop multifactorial models for evaluation of risk of progression, and measures of non-drug secondary prevention of CHF.

Materials And Methods: We included in this study 531 patients with functional class (FC) I-III CHF (FC I - n=254, FC II - n=255, FC III - n=22). Examination included clinical-instrumental, clinical-functional, and laboratory (with determination of NT-proBNP concentration) investigations, use of the AUDIT and Morisky Green questionnaires. Read More

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https://lib.ossn.ru/jour/article/view/587
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http://dx.doi.org/10.18087/cardio.2019.4.10248DOI Listing
April 2019
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