24,311 results match your criteria Diabetes Mellitus and Pregnancy


Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study.

BMC Endocr Disord 2019 Feb 15;19(1):22. Epub 2019 Feb 15.

The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, No. 1961, Huashan Road, Shanghai, 200030, China.

Background: To investigate the frequency and risk factors for recurrent gestational diabetes mellitus (GDM) in Chinese primiparous women.

Methods: Case control study. We investigated primiparous women who experienced GDM complications and had a subsequent pregnancy in the same hospital from January, 2012 to January, 2017. Read More

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http://dx.doi.org/10.1186/s12902-019-0349-4DOI Listing
February 2019

Hyperglycaemia cause vascular inflammation through advanced glycation end products/early growth response-1 axis in gestational diabetes mellitus.

Mol Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, Tamil Nadu, India.

Hyperglycaemia during pregnancy is the main reason for developing diabetes mediated vascular complications. Advanced glycation end products (AGEs) are formed due to non-enzymatic glycation of proteins, lipids and nucleic acids during hyperglycaemia. It has the potential to damage vasculature by modifying the substrate or by means of AGEs and receptor of AGE (RAGE) interaction. Read More

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http://dx.doi.org/10.1007/s11010-019-03503-0DOI Listing
February 2019

Erratum: Effect of Physical Activity during Pregnancy on Gestational Diabetes Mellitus.

Authors:

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):866

[This corrects the article on p. 661 in vol. 22, PMID: 30294578. Read More

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http://dx.doi.org/10.4103/2230-8210.246857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330856PMC
February 2019

Pregnancy Outcomes in Women with Strictly Controlled Type 1 Diabetes Mellitus.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):798-800

Department of Obstetrics and Gynecology, Trakya University, Edirne, Turkey.

Objective: To evaluate the pregnancy outcomes in mothers with controlled Type 1 diabetes mellitus (T1DM).

Materials And Methods: Thirty seven pregnant patients with controlled T1DM were included in the study.

Results: Twenty (54%) out of 37 patients had preterm delivery (<37 weeks of gestation). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330866PMC
February 2019

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion.

J Am Heart Assoc 2019 Feb;8(4):e010647

1 Division of Nephrology & Hypertension Mayo Clinic Rochester MN.

Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy-specific hypertensive disorder characterized by endothelial dysfunction and activation. Methods and Results We examined the sublingual glycocalyx noninvasively using sidestream dark field imaging in the third trimester among women with normotensive pregnancies (n=73), early (n=14) or late (n=29) onset preeclampsia, or gestational diabetes mellitus (n=21). Read More

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http://dx.doi.org/10.1161/JAHA.118.010647DOI Listing
February 2019

Maternal hepatitis B surface antigen carrier status increased the incidence of gestational diabetes mellitus.

BMC Infect Dis 2019 Feb 13;19(1):147. Epub 2019 Feb 13.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13th Hangkong Road, Wuhan, 430030, Hubei, China.

Background: The relationship between chronic hepatitis B virus (HBV) infection with gestational diabetes mellitus (GDM) remains unclear. This study aimed to identify the association between maternal HBsAg-positive status and GDM.

Methods: A retrospective cohort study was performed on the pregnant women who delivered from June 2012 to May 2016 at Wuhan Medical Care Center for Women and Children, Wuhan, China. Read More

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http://dx.doi.org/10.1186/s12879-019-3749-1DOI Listing
February 2019

Mild gestational diabetes: towards a redefined threshold?

Expert Rev Endocrinol Metab 2012 Nov;7(6):669-676

b Obstetric Department, São Paulo Federal University, São Paulo, Brazil.

Gestational diabetes mellitus (GDM), the most common medical complication of pregnancy, is defined as carbohydrate intolerance resulting in hyperglycemia of variable severity with onset or first recognition during pregnancy. In reality, gestational diabetes mellitus is a spectrum of maternal hyperglycemia caused or exacerbated by pregnancy, in which blood glucose levels lie along a continuum, associated with a wide spectrum of metabolic abnormalities and conferring varying degrees of pregnancy-related risk. In recent years, the WHO diagnostic thresholds in current use have been called into question, as increasing evidence mounts that 'mild gestational diabetes' confers increased maternal and fetal risk, despite glucose levels falling below current thresholds. Read More

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http://dx.doi.org/10.1586/eem.12.59DOI Listing
November 2012

Effects of nutritional nursing intervention based on glycemic load for patient with gestational diabetes mellitus.

Ginekol Pol 2019 ;90(1):46-49

Department of Gynecology and Obstetrics, Yantai Hospital of Traditional Chinese Medicine, Yantai City, China.

Objectives: To determine the effects of nutritional nursing intervention based on glycemic load (GL) for patients with gestational diabetes mellitus.

Material And Methods: One hundred thirty-four patients diagnosed with gestational diabetes mellitus at our hospital were selected from March 2015 to March 2017 and randomly divided into the observation (n = 67) and control groups (n = 67). All of the patients in the observation and control groups received conventional nutritional nursing. Read More

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http://dx.doi.org/10.5603/GP.2019.0007DOI Listing
January 2019

Estimation of Serum Zinc, Copper and Magnesium Levels in Bangladeshi women with Gestational Diabetes Mellitus Attending in a Tertiary Care Hospital.

Mymensingh Med J 2019 Jan;28(1):157-162

Dr Farzana Akonjee Mishu, Assistant Professor of Biochemistry, Department of Physiology and Molecular Biology, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine & Metabolic Disorders (BIRDEM), Dhaka, Bangladesh; E-mail:

Zinc (Zn), Copper (Cu) and Magnesium (Mg) are essential trace elements for normal embryogenesis and fetal growth. Alteration of Zn, Cu and Mg concentrations in blood has been observed in normal pregnancy as well as in gestational diabetes mellitus (GDM). Aim of this study was to evaluate the serum Zn, Cu and Mg levels in Bangladeshi women with GDM in their second and third trimester of pregnancy. Read More

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January 2019

[The Impact of Prolonged Use of Continuous Subcutaneous Insulin Infusion in the Control of Type-1 Diabetes].

Acta Med Port 2019 Feb 1;32(1):17-24. Epub 2019 Feb 1.

Serviço de Endocrinologia, Diabetes e Metabolismo. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.

Introduction: The use of continuous subcutaneous insulin infusion therapy in type 1 diabetes mellitus has increased due to its benefits on glycemic control and on the lifestyle flexibility. The aim of this study was to assess the impact of continuous subcutaneous insulin infusion therapy on glycemic control, body mass index, total daily dose of insulin and complications associated with this therapy, during 20 years of experience in Centro Hospitalar e Universitário de Coimbra.

Material And Methods: This retrospective study included patients with type 1 diabetes mellitus who started continuous subcutaneous insulin infusion therapy up until 2005, followed at Centro Hospitalar e Universitário de Coimbra. Read More

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http://dx.doi.org/10.20344/amp.10778DOI Listing
February 2019
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Maternal Dietary Patterns and Their Association with Pregnancy Outcomes.

Clin Nutr Res 2019 Jan 25;8(1):64-73. Epub 2019 Jan 25.

Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Maternal nutritional status during pregnancy will affect the outcomes for the mother and the newborn. Maternal diet was assessed in 150 pregnant women during the first trimester of pregnancy by a 168-item food frequency questionnaire. Dietary patterns were explored by Factor analysis, and association of patterns with maternal and neonatal outcomes such as gestational diabetes mellitus (GDM), anemia and anthropometric indices were determined by analysis of variance and linear regression analysis. Read More

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http://dx.doi.org/10.7762/cnr.2019.8.1.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355947PMC
January 2019

Methylation of HIF3A promoter CpG islands contributes to insulin resistance in gestational diabetes mellitus.

Mol Genet Genomic Med 2019 Feb 11:e583. Epub 2019 Feb 11.

Department of Obstetrics, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Background: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance during pregnancy, and will lead to high risk of diabetes even after pregnancy. Hypoxia-inducible factor (HIF) family proteins are transcriptional factors that are highly correlated with methylation, which might be involved in the regulation of GDM.

Methods: Baseline clinical characteristics of the GDM patients and healthy women were analyzed. Read More

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http://dx.doi.org/10.1002/mgg3.583DOI Listing
February 2019
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Severe cardiovascular morbidity in women with hypertensive diseases during delivery hospitalization.

Am J Obstet Gynecol 2019 Feb 8. Epub 2019 Feb 8.

New Haven CT, Yale School of Medicine.

Background: Cardiovascular disease (CVD) is the leading cause of pregnancy-related death in the United States. (1) Identification of short-term indicators of cardiovascular morbidity has the potential to alter the course of this devastating disease among women. It has been established that hypertensive disorders of pregnancy (HDP) are associated with increased risk of cardiovascular disease 10-30 years after delivery; however, little is known about the association of hypertensive disorders of pregnancy with cardiovascular (CV) morbidity during the delivery hospitalization. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.010DOI Listing
February 2019
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17α-Hydroxyprogesterone Caproate and the Risk of Glucose Intolerance in Pregnancy: A Systematic Review and Meta-analysis.

Obstet Gynecol 2019 Feb 4. Epub 2019 Feb 4.

Division of Maternal Fetal Medicine and Clinical Pharmacology, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine; and Doctoral (PhD) Program in Clinical Investigation, Graduate Training Program in Clinical Investigation (GTPCI), Johns Hopkins University School of Public Health, Baltimore, Maryland.

Objective: To evaluate whether 17α-hydroxyprogesterone caproate use in preventing preterm birth increases the risk of gestational diabetes mellitus (GDM).

Data Sources: Electronic databases (MEDLINE, Scopus, ClinicalTrials.gov, PROSPERO, EMBASE, Scielo and the Cochrane Central Register of Controlled Trials) were searched for studies published before October 2018. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003115DOI Listing
February 2019
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5.175 Impact Factor

Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 7. Epub 2019 Feb 7.

INRS-Institut Armand-Frappier, Université du Québec and Biomed Research Center, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada; Center for Interdisciplinary Research on Well-Being, Health, Society and Environment, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.

Serotonin (5-hydroxytryptamine, 5-HT) regulates diverse physiological and behavioural and processes, also acts as a developmental signal in early embryogenesis and in regulation of fetal development. A number of studies have implicated the prominent role of serotonin transporter (SERT or 5-HTT) and 5-HT receptor subtypes in placental development and function. Here, in this article we have provided a comprehensive review on the important role of 5-HT homeostasis in pregnancy outcomes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.017DOI Listing
February 2019
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Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index.

Clin Epigenetics 2019 Feb 8;11(1):22. Epub 2019 Feb 8.

Diabetes Research Center, Medical School, Ningbo University, 818 Fenghua Road, Ningbo, 315211, Zhejiang, China.

Background: Circular RNA (circRNA) is involved in the pathological processes of various diseases. CircRNA is more stable than linear RNAs and is expressed in high levels in tissues, making it a better biomarker candidate than linear RNAs. In this study, we aimed to identify potential circRNA biomarkers of gestational diabetes mellitus (GDM). Read More

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http://dx.doi.org/10.1186/s13148-019-0610-8DOI Listing
February 2019
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Association between serum thallium in early pregnancy and risk of gestational diabetes mellitus: The Ma'anshan birth cohort study.

J Trace Elem Med Biol 2019 Mar 19;52:151-156. Epub 2018 Dec 19.

Department of Maternal, Child & Adolescent Health, Anhui Medical University, Hefei, China; Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical University, Hefei, China. Electronic address:

Background: High blood glucose has been noted in case reports of acute thallium poisoning, however, effects of low-level exposure of thallium on risk of gestational diabetes mellitus (GDM) has not been explored yet.

Objectives: We aimed to explore the association of serum thallium concentration (STC) in early pregnancy and risk of GDM.

Methods: Data of 3013 women from the Ma'anshan birth cohort study (MABC), China was used. Read More

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http://dx.doi.org/10.1016/j.jtemb.2018.12.011DOI Listing
March 2019
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How diet, physical activity and psychosocial well-being interact in women with gestational diabetes mellitus: an integrative review.

BMC Pregnancy Childbirth 2019 Feb 7;19(1):60. Epub 2019 Feb 7.

Institute of Higher Education and Research in Healthcare (IUFRS), University of Lausanne, 1010, Lausanne, Switzerland.

Background: Gestational Diabetes Mellitus (GDM) is associated with future cardio-metabolic risks for the mother and her child. In addition, one-third of women with recent GDM develop postpartum depression. Given these adverse impacts of GDM on the health of the mother and her offspring, it is important to intervene on modifiable factors, such as diet, physical activity, and psychosocial well-being. Read More

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http://dx.doi.org/10.1186/s12884-019-2185-yDOI Listing
February 2019
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Chewing gum for 1 h does not change gastric volume in healthy fasting subjects. A prospective observational study.

J Clin Anesth 2019 Feb 5;56:100-105. Epub 2019 Feb 5.

Department of Anesthesia, Toronto Western Hospital, 399 Bathurst St, Main Pavilion 2-405, Toronto, ON M5T 2S8, Canada.

Study Objective: Perioperative fasting guidelines differ in their approaches to chewing gum in the preoperative period. Current recommendations range from canceling the surgery to proceeding with it. Given this lack of consensus, we performed gastric ultrasound assessments in healthy volunteers before and after a standardized period of chewing gum. Read More

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http://dx.doi.org/10.1016/j.jclinane.2019.01.021DOI Listing
February 2019
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The relationship between pre-pregnancy dietary patterns adherence and risk of gestational diabetes mellitus in Iran: A case-control study.

Nutr Diet 2019 Feb 6. Epub 2019 Feb 6.

Nutrition and Metabolic Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Aim: The present study aimed to investigate major dietary patterns and their association with risk of gestational diabetes mellitus (GDM) in Yazd city located in Iran.

Methods: This case-control designed study was conducted at six healthcare centres. Two hundred and seventy-eight pregnant women who referred for GDM screening participated. Read More

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http://dx.doi.org/10.1111/1747-0080.12514DOI Listing
February 2019
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History of gestational diabetes mellitus and postpartum maternal retinal microvascular structure and function.

Diabet Med 2019 Feb 6. Epub 2019 Feb 6.

Division of O&G, KK Women's and Children's Hospital, Singapore.

Gestational diabetes mellitus (GDM) is one of the most common complications in pregnancy. The presence of GDM identifies women with increased risks of long-term health problems after delivery, including Type 2 diabetes and cardiovascular diseases (CVD). Because retinal microcirculation may mirror systemic microcirculation, exploring microvascular changes after delivery among women with or without a history of GDM might be key to better understanding such pathophysiological mechanisms. Read More

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http://dx.doi.org/10.1111/dme.13928DOI Listing
February 2019
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Advances in the proteomics of amniotic fluid to detect biomarkers for chromosomal abnormalities and fetomaternal complications during pregnancy.

Expert Rev Proteomics 2019 Feb 5:1-10. Epub 2019 Feb 5.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , SVKM'S NMIMS , V.L. Mehta Road, Vile Parle west, Mumbai - 400056 , India.

Introduction: Amniotic fluid (AF) is a dynamic and complex mixture that reflects the physiological condition of developing fetus. In the last decade, proteomic analysis of AF for 16-18 weeks normal pregnancy has been done for the composition and functions of this fluid. Other body fluids such as urine, sweat, tears, etc. Read More

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http://dx.doi.org/10.1080/14789450.2019.1578213DOI Listing
February 2019
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Association of food groups intake and physical activity with gestational diabetes mellitus in Iranian women.

J Matern Fetal Neonatal Med 2019 Feb 5:1-11. Epub 2019 Feb 5.

h Shirvan Center of Higher Health Education , North Khorasan University of Medical Sciences , Shirvan , Iran.

Background: It is suggested that combining healthy diet with physical activity during and before pregnancy have a significant effect on insulin sensitivity. This study aimed to investigate the relationship between physical activity and diet before and during pregnancy with the risk of gestational diabetes mellitus (GDM).

Methods: A case-control study was conducted on 173 women with GDM diagnosed during the pregnancy as the case group and 168 women with negative test for GDM as controls. Read More

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http://dx.doi.org/10.1080/14767058.2019.1579189DOI Listing
February 2019
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Diet-Gut Microbiota Interactions and Gestational Diabetes Mellitus (GDM).

Nutrients 2019 Feb 3;11(2). Epub 2019 Feb 3.

Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Medical nutritional therapy is the first-line approach in managing gestational diabetes mellitus (GDM). Diet is also a powerful modulator of the gut microbiota, whose impact on insulin resistance and the inflammatory response in the host are well known. Changes in the gut microbiota composition have been described in pregnancies either before the onset of GDM or after its diagnosis. Read More

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http://dx.doi.org/10.3390/nu11020330DOI Listing
February 2019
2 Reads

Large for gestational age and macrosomia in pregnancies without gestational diabetes mellitus.

J Matern Fetal Neonatal Med 2019 Feb 3:1-11. Epub 2019 Feb 3.

a Department of Epidemiology & Biostatistics , School of Public Health , Anhui Medical University , Hefei , China.

Objective: This study aims to estimate the prevalence and risk factors of macrosomia and LGA (large for gestational age) among non-GDM (gestational diabetes mellitus) pregnant women in Fuyang, Anhui Province of China.

Methods: A large population-based cohort study was conducted among non-GDM pregnant women aged 18-45 years. Maternal sociodemographic data prior to pregnancy were collected using interviewer-administered standardized questionnaire. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1578746DOI Listing
February 2019
4 Reads

Why Polycystic Ovary Syndrome (PCOS) needs long-term management?

Curr Pharm Des 2019 Jan 29. Epub 2019 Jan 29.

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing. China.

Background: Polycystic ovary syndrome (PCOS) is a frequent female reproductive endocrine disease. It has been associated with numerous severe reproductive and metabolic abnormalities. However, there are still open questions especially regarding the best long-term management. Read More

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http://www.eurekaselect.com/169465/article
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http://dx.doi.org/10.2174/1381612825666190130104922DOI Listing
January 2019
4 Reads

Maternal obesity and gestational diabetes mellitus affect body composition through infancy: the PONCH study.

Pediatr Res 2018 Dec 10. Epub 2018 Dec 10.

Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: To determine how maternal obesity or gestational diabetes mellitus (GDM) affect infant body size and body composition during the first year of life.

Methods: Eighty three normal-weight (NW) women, 26 obese (OB) women, and 26 women with GDM were recruited during pregnancy. Infant body composition was determined by air-displacement plethysmography at 1 and 12 weeks, and anthropometric measurements made until 1 year of age. Read More

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http://dx.doi.org/10.1038/s41390-018-0248-9DOI Listing
December 2018
1 Read

Maternal metabolic factors during pregnancy predict early childhood growth trajectories and obesity risk: the CANDLE Study.

Int J Obes (Lond) 2019 Jan 31. Epub 2019 Jan 31.

Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

Background: We investigated the individual and additive effects of three modifiable maternal metabolic factors, including pre-pregnancy overweight/obesity, gestational weight gain (GWG), and gestational diabetes mellitus (GDM), on early childhood growth trajectories and obesity risk.

Methods: A total of 1425 mother-offspring dyads (953 black and 472 white) from a longitudinal birth cohort were included in this study. Latent class growth modeling was performed to identify the trajectories of body mass index (BMI) from birth to 4 years in children. Read More

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http://dx.doi.org/10.1038/s41366-019-0326-zDOI Listing
January 2019
2 Reads

[INFLUENCE OF CHRONIC IMMOBILIZATION STRESS DURING PREGNANCY ON MORPHOFUNCTIONAL STATE OF THE LIVER IN FEMALE RATS DURING POSTPARTUM PERIOD].

Georgian Med News 2018 Dec(285):92-96

Kharkiv National Medical University, Ukraine.

Morphofunctional state of the liver (in particular, indexes of carbohydrate, protein, and fat metabolism, structural elements and condition of vascular endothelium of the liver) in female rats subjected to immobilization stress during pregnancy, has been studied. Morphological changes in the liver include discomplexation of beam-radial structure, pyknosis of hepatocyte nucleus, increased regeneration activity of parenchyma, and increased stromal parenchymal index. Functional disorders are manifested by development of dysproteinemia, hyperlipidemia, hyperglycemia, and increased activity of organo-specific liver enzymes. Read More

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December 2018
3 Reads

Vitamin D: effects on pregnancy, maternal, fetal and postnatal outcomes.

Ter Arkh 2018 Nov;90(10):115-127

National Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia.

A high prevalence of vitamin D deficiency and its negative consequences for health is identified as area of primary concern for scientists and clinicians worldwide. Vitamin D deficiency affects not only bone health but many socially significant acute and chronic diseases. Observational studies support that pregnant and lactating women, children and teenagers represent the high risk groups for developing vitamin D deficiency. Read More

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http://ter-arkhiv.ru/en/archive/2018/vol-90-10-2018/vitamin-
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http://dx.doi.org/10.26442/terarkh20189010115-127DOI Listing
November 2018
2 Reads

Adenosine kinase and cardiovascular fetal programming in gestational diabetes mellitus.

Biochim Biophys Acta Mol Basis Dis 2019 Jan 27. Epub 2019 Jan 27.

Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD, 4029, Queensland, Australia. Electronic address:

Gestational diabetes mellitus (GDM) is a detrimental condition for human pregnancy associated with endothelial dysfunction and endothelial inflammation in the fetoplacental vasculature and leads to increased cardio-metabolic risk in the offspring. In the fetoplacental vasculature, GDM is associated with altered adenosine metabolism. Adenosine is an important vasoactive molecule and is an intermediary and final product of transmethylation reactions in the cell. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.01.023DOI Listing
January 2019
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Lean maternal hyperglycemia alters offspring lipid metabolism and susceptibility to Diet-Induced obesity in mice.

Biol Reprod 2019 Jan 29. Epub 2019 Jan 29.

Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, MO, USA.

We previously developed a model of gestational diabetes mellitus (GDM) in which dams exhibit glucose intolerance, insulin resistance and reduced insulin response to glucose challenge only during pregnancy, without accompanying obesity. Here, we aimed to determine how lean gestational glucose intolerance affects offspring risk of metabolic dysfunction. One cohort of offspring was sacrificed at 19 weeks, and one at 31 weeks, with half of the second cohort placed on a high fat high sucrose diet (HFHS) at 23 weeks. Read More

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http://dx.doi.org/10.1093/biolre/ioz009DOI Listing
January 2019
1 Read

Effects of Social Media and Mobile Health Apps on Pregnancy Care: Meta-Analysis.

JMIR Mhealth Uhealth 2019 Jan 30;7(1):e11836. Epub 2019 Jan 30.

Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hong Kong, China (Hong Kong).

Background: The use of social media and mobile health (mHealth) apps has been increasing in pregnancy care. However, the effectiveness of these interventions is still unclear.

Objectives: We conducted a meta-analysis to examine the effectiveness of these interventions with regard to different health outcomes in pregnant and postpartum women and investigate the characteristics and components of interventions that may affect program effectiveness. Read More

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https://mhealth.jmir.org/2019/1/e11836/
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http://dx.doi.org/10.2196/11836DOI Listing
January 2019
8 Reads

Maternal education predicts compliance to exercise during pregnancy.

Acta Obstet Gynecol Scand 2019 Jan 30. Epub 2019 Jan 30.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.

We thank Dr Martin-Arias et al for their interest in our study. They are leaders on the study of the effect of exercise in pregnancy, contributing with several, large, important randomized controlled trails on this topic. Exercise during pregnancy has been shown to be associated with different benefits, including a significantly higher incidence of vaginal delivery and a significantly lower incidence of cesarean delivery, gestational diabetes mellitus, hypertensive disorders and with a reduction in the incidence of preterm birht and gestational diabetes mellitus in overweight and obese pregnant women. Read More

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http://dx.doi.org/10.1111/aogs.13550DOI Listing
January 2019
1 Read
1.985 Impact Factor

Insulin Therapy of Gestational Diabetes Does Not Fully Protect Offspring from Diet-Induced Metabolic Disorders.

Diabetes 2019 Jan 29. Epub 2019 Jan 29.

The Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Zhejiang university school of medicine, Hangzhou, Zhejiang, China

Gestational diabetes mellitus (GDM) is associated with increased risk of metabolic disorders in offspring in later life. Although mounting evidence suggests that therapy for GDM could improve neonatal health, it is not known whether the therapy confers long-term metabolic benefits to offspring in their later adult lives. Here, using a mouse model of diabetes in the latter half of pregnancy to mimic human GDM, we find that the efficient insulin therapy of GDM confers significant protection against glucose intolerance and obesity in offspring fed on normal chow diet. Read More

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http://dx.doi.org/10.2337/db18-1151DOI Listing
January 2019
1 Read

An update on clinical care for pregnant women with acromegaly.

Expert Rev Endocrinol Metab 2019 Jan 17:1-12. Epub 2019 Jan 17.

d Service d'Endocrinologie et des Maladies Métaboliques , Centre Hospitalier Universitaire de Toulouse, Hôpital Larrey , Toulouse , France.

Introduction: As pregnancy is rare in women with acromegaly, only case reports and few series have been published. Areas covered: All case reports and publications dealing with pregnancy in patients with acromegaly were collated. Information concerning the effects of acromegaly on pregnancy outcomes, the impact of pregnancy on GH/IGF-I measurements, acromegaly comorbidity and pituitary adenoma size, the effects of treatment of acromegaly on fetus outcomes were retrieved and analyzed. Read More

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https://www.tandfonline.com/doi/full/10.1080/17446651.2019.1
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http://dx.doi.org/10.1080/17446651.2019.1571909DOI Listing
January 2019
8 Reads

Diabetes screening in pregnancy failing women in rural Western Australia: An audit of oral glucose tolerance test completion rates.

Aust J Rural Health 2019 Feb 29;27(1):64-69. Epub 2019 Jan 29.

Rural Clinical School of Western Australia, University of Western Australia, Bunbury, Western Australia, Australia.

Objective: To quantify screening rate for gestational diabetes mellitus and completion of oral glucose tolerance test in rural and remote Western Australia.

Design And Participants: Retrospective audit of 551 antenatal records from women of 16 years and older without pre-existing diabetes and with singleton pregnancies delivered in 2013.

Main Outcome Measures: Number of women recorded screened for gestational diabetes mellitus in second or third trimester using oral glucose tolerance test or other tests; gestational diabetes mellitus rate. Read More

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http://dx.doi.org/10.1111/ajr.12465DOI Listing
February 2019
1 Read

Osteocalcin Serum Levels in Gestational Diabetes Mellitus and Their Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis.

J Diabetes Res 2018 30;2018:4986735. Epub 2018 Dec 30.

Fetal i+D Fetal Medicine Research Center, BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, Spain.

Background: Undercarboxylated osteocalcin (ucOC) increases insulin release and insulin resistance in mice. In humans, evidence is scarce but a correlation of ucOC and total osteocalcin (tOC) with glycemic status markers has been demonstrated. The relationship of ucOC and tOC with gestational diabetes mellitus (GDM) has been even less characterized. Read More

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http://dx.doi.org/10.1155/2018/4986735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332945PMC
December 2018
1 Read

Diagnostic accuracy of HbA1c in detecting gestational diabetes mellitus.

J Matern Fetal Neonatal Med 2019 Feb 11:1-4. Epub 2019 Feb 11.

a Department of Obstetrics and Gynecology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.

Objective: To investigate the diagnostic value of glycated hemoglobin A1c (HbA1c) in detecting gestational diabetes mellitus (GDM).

Methods: Pregnant women at gestational age 24 weeks or more, who had abnormal GDM screening test, were enrolled in this prospective study. A HbA1c assessment was performed at the same time of 3-h 100 g oral glucose tolerance test (OGTT). Read More

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http://dx.doi.org/10.1080/14767058.2019.1576169DOI Listing
February 2019
3 Reads

Role of gestational weight gain, gestational diabetes, breastfeeding, and hypertension in mother-to-child obesity transmission.

Pol Arch Intern Med 2019 Jan 28. Epub 2019 Jan 28.

Given the reported 30% prevalence of early-life obesity in Western countries, the non-genetic maternally-derived risk factors for excess body mass in offspring have been widely investigated recently. This review article aimed to analyze the results of 67 articles published from 2014 onwards that investigated causative non-genetic-based associations between maternal and infantile excess body mass. Excessive gestational weight gain was found to increase the incidence of excess body mass in offspring, reaching nearly 20% by 2 years of age. Read More

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http://pamw.pl/en/node/4426
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http://dx.doi.org/10.20452/pamw.4426DOI Listing
January 2019
6 Reads

Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies.

Clin Sci (Lond) 2019 Jan 25;133(2):315-319. Epub 2019 Jan 25.

Epigenetics Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia and Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia

Healthy development in utero relies on the appropriate exchange of nutrients and other signalling between the maternal and fetal circulations. Disruption to this fine balance is associated with several pregnancy and adverse birth outcomes, including gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. Read More

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http://dx.doi.org/10.1042/CS20180901DOI Listing
January 2019
1 Read
5.598 Impact Factor

Evidence in support of the international association of diabetes in pregnancy study groups' criteria for diagnosing gestational diabetes worldwide in 2019.

Am J Obstet Gynecol 2019 Jan 22. Epub 2019 Jan 22.

Mater Health and Mater Research, University of Queensland, Queensland, Australia.

Gestational diabetes mellitus is the most frequent medical complication of pregnancy, affecting 5-6% of women in the USA using the currently predominant Carpenter Coustan criteria, which still represent the preferred approach of the American College of Obstetricians and Gynecologists. Alternative criteria proposed by the International Association of Diabetes in Pregnancy Study Groups (IADPSG) would likely increase gestational diabetes (GDM) prevalence to 15 - 20%, due both to a one step testing policy and the requirement for only one elevated glucose value for diagnosis. Increasing GDM prevalence relates to older maternal age and the increasing prevalence of overweight and obesity. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.206DOI Listing
January 2019
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Low empowerment and diabetes regimen distress are related to HbA1c in low income type 1 diabetes patients in a Brazilian tertiary public hospital.

Diabetol Metab Syndr 2019 22;11. Epub 2019 Jan 22.

2Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, São Paulo Brazil.

Background: Adults with type 1 diabetes (T1D) have a high risk of developing depressive symptoms and diabetes-related distress (DD). Low socioeconomic level is associated with increased risk of poor self-management, treatment difficulties and psychological distress. The goals of this study were to document the frequency of major depressive disorder (MDD), high depressive symptoms and high DD, to assess levels of empowerment and to determine the association with each of these measures and glycemic control in a low-income Brazilian sample of adults with T1D. Read More

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https://dmsjournal.biomedcentral.com/articles/10.1186/s13098
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http://dx.doi.org/10.1186/s13098-019-0404-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341746PMC
January 2019
3 Reads

Isolated effect of maternal thyroid-stimulating hormone, free thyroxine and antithyroid peroxidase antibodies in early pregnancy on gestational diabetes mellitus: a birth cohort study in China.

Endocr J 2019 Jan 24. Epub 2019 Jan 24.

School of Public Health, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

This article aims to understand the isolated effect of maternal thyroid-stimulating hormone (TSH), free thyroxine (FT) and antithyroid peroxidase antibodies (TPOAb) in early pregnancy on gestational diabetes mellitus (GDM). Based on a birth cohort, pregnant women presented to maternity hospitals for the first antenatal care from Nov 2008 to Oct 2010 were invited to participate in the study. A self-administered questionnaire was asked to complete to collect data on socio-economic variables, previous adverse pregnancy outcomes, method of conception, previous endocrinic and metabolic diseases, and pregnancy-related anxiety in 1 trimester of the index pregnancy. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0340DOI Listing
January 2019
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Is there a connection between gestational diabetes mellitus, human immunodeficiency virus infection, and tuberculosis?

Int J Tuberc Lung Dis 2019 Jan;23(1):19-25

Center for Global Health, Weill Cornell Medicine, New York, New York, USA.

Pregnancy is associated with insulin resistance similar to that found in type 2 diabetes mellitus (DM). The prevalence of gestational diabetes mellitus (GDM) in key tuberculosis (TB) endemic countries, such as India and China, has been increasing rapidly in the last decade and may be higher in human immunodeficiency virus (HIV) infected women. Pregnancy is also an independent risk factor for developing active TB; however, little is known about the interaction of GDM, HIV and TB. Read More

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http://dx.doi.org/10.5588/ijtld.18.0337DOI Listing
January 2019
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Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity-A systematic review, meta-analysis, and meta-regression.

Obes Rev 2019 Jan 23. Epub 2019 Jan 23.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Polycystic ovary syndrome (PCOS) is associated with an increased risk of maternal pregnancy and delivery complications. However, the impact of clinical features of PCOS and other potential risk factors in PCOS is still unknown. We aimed to investigate the association of PCOS with maternal pregnancy and delivery complications with consideration of risk factors and potential confounders. Read More

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http://dx.doi.org/10.1111/obr.12829DOI Listing
January 2019
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The risk of Helicobacter pylori infection for adverse pregnancy outcomes: A systematic review and meta-analysis.

Helicobacter 2019 Jan 22:e12562. Epub 2019 Jan 22.

School of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Objective: To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes.

Materials And Methods: A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size. Read More

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http://doi.wiley.com/10.1111/hel.12562
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http://dx.doi.org/10.1111/hel.12562DOI Listing
January 2019
6 Reads

Early Subclinical Atherosclerosis in Gestational Diabetes: The Predictive Role of Routine Biomarkers and Nutrigenetic Variants.

J Diabetes Res 2018 24;2018:9242579. Epub 2018 Dec 24.

Department of Medicine and Aging, School of Medicine and Health Sciences, "G. d'Annunzio" University, Chieti-Pescara, Chieti, Italy.

Gestational diabetes mellitus (GDM) can be considered a silent risk for out-of-pregnancy diabetes mellitus (DM) and cardiovascular disease (CVD) later in life. We aimed to assess the predictive role of 3 trimester lipid profile during pregnancy for the susceptibility to markers of subclinical atherosclerosis (CVD susceptibility) at 3 years in a cohort of women with history of GDM. A secondary aim is to evaluate the usefulness of novel nutrigenetic markers, in addition to traditional parameters, for predicting early subclinical atherosclerosis in such women in order to plan adequate early prevention interventions. Read More

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https://www.hindawi.com/journals/jdr/2018/9242579/
Publisher Site
http://dx.doi.org/10.1155/2018/9242579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323479PMC
December 2018
2 Reads

Validity of over the counter finger stick glucose measurement devices in comparison with laboratory venous plasma glucose measurements on pregnant women with diabetes

Ceylon Med J 2018 Dec;63(4):180-185

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Peradeniya, Sri Lanka.

Introduction: Self-monitoring of fasting, pre and postprandial blood glucose (SMBG) is an integral part of diabetic care. The validity and accuracy of different glucometer types vary significantly and at present ,none of the local authorities carry out pre or post marketing evaluation of these devices in Sri Lanka. This study evaluated the accuracy and validity of 3 types of SMBG devices available over the counter, Device 1, Device 2 and Device 3 against a standard laboratory reference method. Read More

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http://dx.doi.org/10.4038/cmj.v63i4.8769DOI Listing
December 2018
1 Read