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    The effects of probiotics supplementation on metabolic health in pregnant women: An evidence based meta-analysis.
    PLoS One 2018 21;13(5):e0197771. Epub 2018 May 21.
    Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    The prevalence of maternal obesity and gestational diabetes mellitus (GDM) is increasing rapidly. Probiotics supplementation have been shown to improve metabolic health in humans. In our study, we aimed to evaluate the effects of probiotics supplementation on metabolic health and pregnancy complications in pregnant women. Read More

    The role of new adipokines in gestational diabetes mellitus pathogenesis.
    Ginekol Pol 2018 ;89(4):222-227
    Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Poland, Jaczewskiego 8, 20-954 Lublin, Poland.
    Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition dur-ing pregnancy. Explanation of the GDM pathogenesis is important due to preventing gestational complications. During pregnancy there are significant changes in maternal metabolism. Read More

    The trends and risk factors to predict adverse outcomes in gestational diabetes mellitus: a 10-year experience from 2006 to 2015 in a single tertiary center.
    Obstet Gynecol Sci 2018 May 17;61(3):309-318. Epub 2018 Apr 17.
    Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Objective: To investigate the change of maternal characteristics, delivery and neonatal outcomes in gestational diabetes mellitus (GDM) over recent 10 years and to identify the risk factors associated with adverse outcome.

    Methods: Consecutive GDM patients (n=947) delivered in our institution were included. Research period was arbitrarily divided into 2 periods (period 1: from 2006 to 2010, period 2: from 2011 to 2015). Read More

    Fulminant Type 1 Diabetes Mellitus Presenting 15 Days after Delivery Diagnosed in Cooperation with Obstetricians.
    Intern Med 2018 May 18. Epub 2018 May 18.
    Department of Endocrinology and Diabetes, National Hospital Organization KURE Medical Center, Japan.
    The patient was a 32-year-old Japanese woman who was given a 75-g oral glucose tolerance test at the 35th week of pregnancy and was normoglycemic. She had excessive thirst and polyuria from 15 days after delivery. When she visited for the 1-month postpartum checkup, her plasma glucose level was 479 mg/dL, HbA1c was 7. Read More

    Guidelines on Diabetic Eye Care: The International Council of Ophthalmology Recommendations for Screening, Follow-up, Referral, and Treatment Based on Resource Settings.
    Ophthalmology 2018 May 15. Epub 2018 May 15.
    Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
    Diabetes mellitus (DM) is a global epidemic and affects populations in both developing and developed countries, with differing health care and resource levels. Diabetic retinopathy (DR) is a major complication of DM and a leading cause of vision loss in working middle-aged adults. Vision loss from DR can be prevented with broad-level public health strategies, but these need to be tailored to a country's and population's resource setting. Read More

    Knowledge and Health Beliefs about Gestational Diabetes and Healthy Pregnancy's Breastfeeding Intention.
    J Clin Nurs 2018 May 18. Epub 2018 May 18.
    College of Nursing, Gachon University, Incheon, Republic of Korea.
    Aims And Objectives: If the knowledge and health beliefs relating to gestational diabetes mellitus (GDM) during pregnancy are associated with behaviours during pregnancy and lactation, this suggests potential educational interventions.

    Backgrounds: Women with GDM are more likely to develop type 2 diabetes mellitus (T2DM), and babies with GDM incur increased risk of neonatal hypoglycaemia and childhood obesity. Breastfeeding is an effective way to improve maternal and lipid metabolism of gestational diabetes mothers, and to lower the risk of T2DM after birth, to prevent conception. Read More

    Epidemiological analysis of maternal lipid levels during the second trimester in pregnancy and the risk of adverse pregnancy outcome adjusted by pregnancy BMI.
    J Clin Lab Anal 2018 May 17:e22568. Epub 2018 May 17.
    Department of Laboratory Medicine, Obstetrics and Gynecology, Hospital of Fudan University, Shanghai, China.
    Background: Pregnancy is accompanied by profound changes in lipid metabolism. We aimed to assess whether effects of second trimester body mass index and maternal lipid concentrations are associated with an increased risk of adverse pregnancy outcomes.

    Methods: We investigated the serum levels of maternal lipids during the second trimester in pregnancy, and analyzed associations between the lipid levels and the risk of adverse pregnancy outcome. Read More

    Effect of inositol stereoisomers at different dosages in gestational diabetes: an open-label, parallel, randomized controlled trial.
    Acta Diabetol 2018 May 17. Epub 2018 May 17.
    Department of Medicine and Aging, School of Medicine and Health Sciences, "G. d'Annunzio" University Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy.
    Aims: Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women.

    Methods: Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27. Read More

    Poor sleep during early pregnancy increases subsequent risk of gestational diabetes mellitus.
    Sleep Med 2018 Jun 22;46:20-25. Epub 2018 Mar 22.
    Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
    Objectives: To examine the relationship between poor sleep quality during pregnancy and the risk of gestational diabetes mellitus (GDM).

    Methods: A total of 4066 singleton pregnant women from the Tongji Maternal and Child Health Cohort (TMCHC) without overt diabetes before pregnancy were analyzed. Sleep quality and duration during early pregnancy were self-reported by enrolled women at their first antenatal care visit before 16 weeks of gestation. Read More

    Low placental visfatin expression is related to impaired glycaemic control and fetal macrosmia in pregnancies complicated by type 1 diabetes.
    J Physiol Pharmacol 2018 Feb 8;69(1):61-66. Epub 2018 May 8.
    Department of Obstetrics and Women's Diseases, Karol Marcinkowski University of Medical Sciences, Poznan, Poland.
    Type 1 diabetes mellitus (T1DM) is still related to altered fetal growth and severe maternal complications. We studied the possible role of placental visfatin/nicotinamide phosphoribosyltransferase (NAMPT) in fetal development in T1DM pregnancies, the possible role of placental visfatin in fetal macrosomia. Sixty five pregnant women with T1DM and singleton pregnancy were qualified into the study. Read More

    Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum.
    Microbiome 2018 May 15;6(1):89. Epub 2018 May 15.
    Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Genetics, Faculty of Health and Medical Science, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
    Background: Imbalances of gut microbiota composition are linked to a range of metabolic perturbations. In the present study, we examined the gut microbiota of women with gestational diabetes mellitus (GDM) and normoglycaemic pregnant women in late pregnancy and about 8 months postpartum.

    Methods: Gut microbiota profiles of women with GDM (n = 50) and healthy (n = 157) pregnant women in the third trimester and 8 months postpartum were assessed by 16S rRNA gene amplicon sequencing of the V1-V2 region. Read More

    Iron Status and Gestational Diabetes-A Meta-Analysis.
    Nutrients 2018 May 15;10(5). Epub 2018 May 15.
    Department of Laboratory Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02215, USA.
    A meta-analysis of the association of iron overload with gestational diabetes mellitus (GDM) may inform the health debate. We performed a meta-analysis investigating the association of iron biomarkers and dietary iron exposure with GDM. We identified 33 eligible studies ( = 44,110) published in 2001⁻2017. Read More

    Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus.
    Gut 2018 May 14. Epub 2018 May 14.
    Computational Genomics Lab, Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
    Objective: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates.

    Design: Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected. Read More

    Screening of Gestational Diabetes and Hypertension Among Antenatal Women in Rural West India.
    Cent Asian J Glob Health 2014 8;3(1):140. Epub 2014 Dec 8.
    Gujarat Cancer Society (GCS) Medical College Hospital & Research Centre, Ahmedabad, Gujarat, India.
    Background: Hypertension and gestational diabetes are among the leading causes of maternal and perinatal mortality, especially in rural areas of developing countries with meager health facilities. With early diagnosis and timely treatment, these adverse events can be decreased. The primary aim of this study was to implement a screening program for gestational diabetes and hypertension, and to assess risk factors associated with these conditions among antenatal women in the rural area of the Gujarat province in India. Read More

    Pregnancy-Related Risk Factors Are Associated With a Significant Burden of Treated Hypertension Within 10 Years of Delivery: Findings From a Population-Based Norwegian Cohort.
    J Am Heart Assoc 2018 May 13;7(10). Epub 2018 May 13.
    Divisions of Health Data and Digitalization and Mental and Physical Health, Norwegian Institute of Public Health, Bergen and Oslo, Norway.
    Background: The association between pregnancy complications and women's later cardiovascular disease has, primarily, been evaluated in studies lacking information on important covariates. This report evaluates the prospective associations between pregnancy-related risk factors (preeclampsia/eclampsia, gestational hypertension, pregestational and gestational diabetes mellitus, preterm delivery, and fetal growth restriction) and pharmacologically treated hypertension within 10 years after pregnancy, while adjusting for a wide range of covariates.

    Methods And Results: Prepregnancy normotensive women participating in the MoBa (Norwegian Mother and Child Cohort Study) from January 2004 through July 2009 were linked to the Norwegian Prescription Database to identify women with pharmacologically treated hypertension beyond the postpartum period of 3 months. Read More

    Impact of a History of Hypertension in Pregnancy on Later Diagnosis of Atrial Fibrillation.
    J Am Heart Assoc 2018 May 13;7(10). Epub 2018 May 13.
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
    Background: Atrial fibrillation/flutter (AF) produces significant morbidity in women and is typically attributed to cardiac remodeling from multiple causes, particularly hypertension. Hypertensive pregnancy disorders (HPDs) are associated with future hypertension and adverse cardiac remodeling. We evaluated whether women with AF were more likely to have experienced a HPD compared with those without. Read More

    Maternal diabetes alters the development of ductus venosus shunting in the fetus.
    Acta Obstet Gynecol Scand 2018 May 11. Epub 2018 May 11.
    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen.
    Introduction: Despite adequate glycemic control, the risks of fetal macrosomia and perinatal complications are increased in diabetic pregnancies. Adjustments of the umbilical venous (UV) distribution, including increased ductus venosus (DV) shunting, can be important fetal compensatory mechanisms, but the impact of pregestational diabetes on UV and DV flow is not known.

    Material And Methods: In this prospective study, 49 women with pregestational diabetes mellitus underwent monthly ultrasound examinations from gestational week 20 to 36. Read More

    Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study.
    Acta Diabetol 2018 May 12. Epub 2018 May 12.
    Unit for Pediatric Endocrinology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
    Aims: Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study.

    Methods: Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis. Read More

    Advances in assessing body composition during pregnancy.
    Eur J Clin Nutr 2018 May 2;72(5):645-656. Epub 2018 May 2.
    Reproductive Endocrinology and Women's Health, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
    The prevalence of excess gestational weight gain is increasing worldwide and is associated with pregnancy complications, including gestational diabetes mellitus, pre-eclampsia, preterm birth, macrosomia, and development of obesity in offspring. Whereas gestational weight gain positively correlates with the gain in fat mass (FM), fat-free mass (FFM) gain is relatively consistent across pregnancies. Commonly used methods to assess body composition include anthropometry, densitometry (air displacement plethysmography, underwater weighing), and hydrometry (isotope dilution, bioimpedance analysis). Read More

    Gestational Diabetes: Underpinning Principles, Surveillance, and Management.
    Obstet Gynecol Clin North Am 2018 Jun;45(2):299-314
    Department of Obstetrics and Gynecology, Section on Maternal-Fetal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
    Gestational diabetes mellitus (GDM) is carbohydrate intolerance resulting in hyperglycemia with onset during pregnancy. The article aims to provide clinicians with a working framework to minimize maternal and neonatal morbidity. Landmark historical and recent data are reviewed and presented to provide clinicians with a quick, easy reference for recognition and management of GDM. Read More

    Pregnancy outcomes in women with gestational diabetes mellitus diagnosed according to the WHO-2013 and WHO-1999 diagnostic criteria: a multicentre retrospective cohort study.
    BMC Pregnancy Childbirth 2018 May 10;18(1):152. Epub 2018 May 10.
    Department of Obstetrics and Gynaecology, Deventer Hospital, Deventer, the Netherlands.
    Background: The World Health Organization (WHO) adopted more stringent diagnostic criteria for GDM in 2013, to improve pregnancy outcomes. However, there is no global consensus on these new diagnostic criteria, because of limited evidence. The objective of the study was to evaluate maternal characteristics and pregnancy outcomes in two cohorts in the Netherlands applying different diagnostic criteria for GDM i. Read More

    The treatment of booking gestational diabetes mellitus (TOBOGM) pilot randomised controlled trial.
    BMC Pregnancy Childbirth 2018 May 10;18(1):151. Epub 2018 May 10.
    School of Medicine, Western Sydney University, Penrith, NSW, 2571, Australia.
    Background: We piloted a randomised controlled trial (RCT) comparing pregnancy outcomes among women with booking gestational diabetes (GDM) receiving immediate or deferred treatment.

    Methods: Consecutive, consenting women < 20 weeks gestation, with GDM risk factors attending the hospital book-in clinic, completed an oral glucose tolerance test (OGTT). Clinicians were blinded to OGTT results. Read More

    BENEFITS OF EARLY SCREENING AND PROPER TREATMENT IN PATIENT WITH SIGNIFICANT RISK FACTORS FOR GESTATIONAL DIABETES MELLITUS (CASE REPORT).
    Georgian Med News 2018 Apr(277):44-48
    University clinic of endocrinology, diabetes and metabolic disorders; PHI General Hospital "8th of September", Skopje, Macedonia.
    Gestational diabetes mellitus (GDM) occurs in 2-9% of all pregnancies. Evidence suggests that the use of insulin in treating hyperglycemia in GDM patients reduces the risk of perinatal morbidity. Pregnancy is an exciting time in a woman's life. Read More

    DIABETIC NEPHROPATHY IN PREGNANT WOMEN WITH TYPE 1 DIABETES (MULTIPLE CASES REVIEW AND DISCUSSION).
    Georgian Med News 2018 Apr(277):15-20
    Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Vojvodina, Medical Faculty, University of Novi Sad, Serbia; Clinic for Gynecology and Obstetrics, Clinical Center of Vojvodina, Medical Faculty, University of Novi Sad, Serbia.
    Pregnancy in women with pre-existing diabetes is associated with a doubled, or even up to four-fold increased risk of preeclampsia, preterm delivery, and perinatal mortality compared to the risk observed in a background population. Diabetic nephropathy (DN) is a progressive disease that affects about one third of diabetic patients and is among the most frequent causes of the end stage renal disease (ESRD) worldwide. In the random population, it is present in up to 7% of women with type 1 diabetes mellitus (T1DM), and it represents the most common chronic kidney disease occurring in graviditas, complicating between 2. Read More

    Maternal Non-glycemic Contributors to Fetal Growth in Obesity and Gestational Diabetes: Spotlight on Lipids.
    Curr Diab Rep 2018 May 9;18(6):37. Epub 2018 May 9.
    Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado, Anschutz Medical Campus, 12801 E 17th Ave, Room 7103; Mail Stop 8106, Aurora, CO, 80045, USA.
    Purpose Of Review: Excess fetal growth is increasingly recognized as a risk factor for childhood obesity, and mounting evidence supports that maternal glucose is not the only driver. This review focuses on the role of clinically applicable maternal non-glycemic contributors to excess fetal growth, particularly lipids, in addition to amino acids (AA), insulin resistance, inflammation, maternal nutrition, and gestational weight gain (GWG) in obesity and gestational diabetes mellitus (GDM).

    Recent Findings: Lipids, specifically triglycerides and free fatty acids, appear to be strong contributors to excess fetal fat accretion and adiposity at birth, particularly in obese pregnancies, which account for the largest number of large-for-gestational-age infants. Read More

    The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus.
    J Endocrinol 2018 May 9. Epub 2018 May 9.
    M Haluzik, First Faculty of Medicine, Institute of Medical Biochemistry and Laboratory Diagnostics, Charles University, Prague, Czech Republic
    Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most common complication of pregnancy. The underlying pathophysiology shares some common features with type 2 diabetes mellitus combining relatively insufficient insulin secretion with increased peripheral insulin resistance. Read More

    Gestational diabetes with diabetes and prediabetes risks: A large observational study.
    Eur J Endocrinol 2018 May 9. Epub 2018 May 9.
    G Hu, Chronic disease epidemiology, Pennington Biomedical Research Center, Baton Rouge, United States
    Aims To compare risks of early postpartum diabetes and prediabetes in Chinese women with and without gestational diabetes mellitus (GDM) during pregnancy Subjects and methods Tianjin GDM observational study included 1263 women with a history of GDM and 705 women without GDM who participated in the urban GDM universal screening survey by using World Health Organization's criteria. Postpartum diabetes and prediabetes were identified after a standard oral glucose tolerance test. Cox proportional hazards regression was used to assess risks of postpartum diabetes and prediabetes between women with and without GDM. Read More

    Risk factors for hyperglycemia in pregnancy in the DALI study differ by period of pregnancy and OGTT time point.
    Eur J Endocrinol 2018 May 8. Epub 2018 May 8.
    R Corcoy, Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    OBJECTIVE Risk factors are widely used to identify women at risk for gestational diabetes mellitus (GDM) without clear distinction by pregnancy period or oral glucose tolerance test (OGTT) time points. We aimed to assess clinical risk factors for HiP differentiating by these two aspects. DESIGN AND METHODS 971 overweight/obese pregnant women, enrolled in the DALI study for preventing GDM. Read More

    Angiogenic Dysregulation in Pregnancy-Related Hypertension-A Role for Metformin.
    Reprod Sci 2018 Jan 1:1933719118773484. Epub 2018 Jan 1.
    1 Department of Human Physiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
    In the face of escalating maternal and fetal health threats, hypertensive pregnancy disorders (HPDs) is one of the leading cause of maternal and fetal morbidity and mortality. The range of HPDs include white-coat hypertension, chronic hypertension, gestational hypertension, mild-to-moderate and severe preeclampsia and eclampsia. Current evidence implicates an imbalance of circulating anti- and angiogenic factors in HPDs emanating from the placental vasculature, impacting on angiogenesis. Read More

    Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice.
    Am J Obstet Gynecol 2018 May 4. Epub 2018 May 4.
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA. Electronic address:
    Background: Diabetes mellitus in early pregnancy increases the risk of birth defects in infants. Maternal hyperglycemia stimulates the expression of nitric oxide (NO) synthase 2 (NOS2), which can be regulated by transcription factors of the nuclear factor-κB (NF-κB) family. Increases in reactive nitrogen species (RNS) generate intracellular stress conditions, including nitrosative, oxidative, and endoplasmic reticulum (ER) stresses, and trigger programmed cell death (or apoptosis) in the neural folds, resulting in neural tube defects (NTDs) in the embryo. Read More

    Previous Gestational Diabetes Increases Atherogenic Dyslipidemia in Subsequent Pregnancy and Postpartum.
    Lipids 2018 May 6. Epub 2018 May 6.
    Department of Medicine, Universitat Autònoma de Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
    In a cohort of women with previous gestational diabetes mellitus (GDM), we aimed to ascertain whether women with abnormal glucose tolerance 1-year postdelivery had a more atherogenic lipid profile during and after pregnancy than those with normal glucose tolerance. A prospective cohort study with longitudinal design between January 2004 and March 2016 was conducted. Three hundred and six (56. Read More

    Predictive factors of gestational diabetes in pregnancies following assisted reproductive technology: a nested case-control study.
    Arch Gynecol Obstet 2018 May 5. Epub 2018 May 5.
    Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.
    Purpose: To evaluate predictive factors for gestational diabetes mellitus (GDM) in singleton pregnancy following assisted reproductive technology (ART).

    Methods: This nested case-control study was performed during October 2016-June 2017. Pregnant women who conceived following ART procedures referred to infertility clinic were selected and categorized into GDM and non-GDM based on ADA/IAPDSG criteria. Read More

    Pharmacotherapy for Hyperglycemia in Pregnancy- The New Insulins.
    Diabetes Res Clin Pract 2018 May 3. Epub 2018 May 3.
    Division of Maternal Fetal Medicine, Helen Schneider Women's Hospital, Rabin Medical Center, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
    Hyperglycemia in pregnancy may lead to adverse maternal, fetal and neonatal outcomes. Tight glycemic control is prudent in order to reduce pregnancy complications. For many years, the gold standard pharmacological therapy during pregnancy was human insulin. Read More

    Early Elevated Alkaline Phosphatase Increases the Risk of Large-for-Gestational-Age Birth Weight in Pregnant Women with Normal Glucose Tolerance.
    Diabetes Res Clin Pract 2018 May 3. Epub 2018 May 3.
    Shanghai Key Laboratory of Diabetes, Department of Endocrinology & Metabolism, Shanghai Jiao-Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai, China.
    Aims: The aim of this study was to assess the association between levels of alkaline phosphatase (ALP) in early pregnancy and the incidence of large-for-gestational-age (LGA) neonates in pregnant women without gestational diabetes mellitus.

    Methods: A prospective cohort was carried out in 544 women and their biochemical parameters including serum ALP and demographic characteristics were collected in 13-16th gestational week. At 24-28th weeks of gestation, 50g oral glucose challenge test and oral 75 g glucose tolerance test was performed. Read More

    Altered expression of PGC-1α and PDX1 and their methylation status are associated with fetal glucose metabolism in gestational diabetes mellitus.
    Biochem Biophys Res Commun 2018 Jun 7;501(1):300-306. Epub 2018 May 7.
    Department of Neonatology, Affiliated Taizhou Hospital of Wenzhou Medical College, Linhai, Zhejiang Province, 317000, China.
    Purpose: To investigate the effect of gestational diabetes mellitus (GDM) on the expression and methylation of PGC-1α and PDX1 in placenta and their effects on fetal glucose metabolism.

    Methods: 20 cases of full-term placenta without pregnancy complications and umbilical cord abnormalities and 20 cases of GDM group were collected. DNA and RNA were isolated from samples of tissue collected from the fetal side of the placenta immediately after delivery. Read More

    Gestational Diabetes Mellitus and Renal Function: A Prospective Study With 9- to 16-Year Follow-up After Pregnancy.
    Diabetes Care 2018 May 4. Epub 2018 May 4.
    Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD
    Objective: To examine whether gestational diabetes mellitus (GDM), independent of subsequent diabetes, is an early risk factor for renal impairment long term after the index pregnancy.

    Research Design And Methods: In the Diabetes & Women's Health (DWH) study (2012-2016), we examined the independent and joint associations of GDM and subsequent diabetes with long-term renal function among 607 women with and 619 women without GDM in the Danish National Birth Cohort (DNBC) index pregnancy (1996-2002). At median follow-up of 13 years after the index pregnancy, serum creatinine (mg/dL) and urinary albumin (mg/L) and creatinine (mg/dL) were measured, from which estimated glomerular filtration rate (eGFR) (mL/min/1. Read More

    Implementation and Effects of Risk-Dependent Obstetric Care in the Netherlands (Expect Study II): Protocol for an Impact Study.
    JMIR Res Protoc 2018 May 4;7(5):e10066. Epub 2018 May 4.
    Care and Public Health Research Institute, Department of Epidemiology, Maastricht University, Maastricht, Netherlands.
    Background: Recently, validated risk models predicting adverse obstetric outcomes combined with risk-dependent care paths have been made available for early antenatal care in the southeastern part of the Netherlands. This study will evaluate implementation progress and impact of the new approach in obstetric care.

    Objective: The objective of this paper is to describe the design of a study evaluating the impact of implementing risk-dependent care. Read More

    Obesity Management Task Force of the European Association for the Study of Obesity Released "Practical Recommendations for the Post-Bariatric Surgery Medical Management".
    Obes Surg 2018 May 4. Epub 2018 May 4.
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
    Bariatric patients may face specific clinical problems after surgery, and multidisciplinary long-term follow-up is usually provided in specialized centers. However, physicians, obstetricians, dieticians, nurses, clinical pharmacists, midwives, and physical therapists not specifically trained in bariatric medicine may encounter post-bariatric patients with specific problems in their professional activity. This creates a growing need for dissemination of first level knowledge in the management of bariatric patients. Read More

    First-Trimester Abdominal Adipose Tissue Thickness to Predict Gestational Diabetes.
    J Obstet Gynaecol Can 2018 Apr 30. Epub 2018 Apr 30.
    Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec City, QC; CHU de Québec-Université Laval Research Center, Québec City, QC. Electronic address:
    Objective: To estimate the discriminative capacity of first-trimester subcutaneous (SATT), visceral (VATT), and total (TATT) adipose tissue thickness in predicting gestational diabetes mellitus (GDM), including that requiring insulin.

    Methods: We prospectively recruited a cohort of 1048 nulliparous women. Ultrasound images were used to determine abdominal SATT, VATT, and TATT at 11 to 14 weeks' gestation. Read More

    Higher cord blood levels of fatty acids in pregnant women with type 1 diabetes mellitus.
    J Clin Endocrinol Metab 2018 May 1. Epub 2018 May 1.
    Referral Center for Diabetes in Pregnancy, Ministry of Health Republic of Croatia, Clinical Department of Obstetrics and Gynecology, Zagreb University Hospital Center, School of Medicine, University of Zagreb, Zagreb, Croatia.
    Context: Type 1 diabetes mellitus is associated with a disturbance of carbohydrate and lipid metabolism.

    Objective: To determine whether type 1 diabetes mellitus (T1DM) alters maternal and neonatal fatty acid levels.

    Design: Observational study. Read More

    The Influence of Maternal Obesity on Pregnancy Complications and Neonatal Outcomes in Diabetic and Nondiabetic Women.
    Geburtshilfe Frauenheilkd 2018 Apr 26;78(4):400-406. Epub 2018 Apr 26.
    Zekai Tahir Burak Women's Health Education and Research Hospital, Perinatology Department, Ankara, Turkey.
    Introduction: This study aimed to investigate the influence of obesity on pregnancy complications and neonatal outcomes in diabetic and nondiabetic women.

    Materials And Methods: This retrospective case control study was conducted on 1193 pregnant women and their neonates at a tertiary level maternity hospital between March 2007 and 2011. The pregnant women were classified into 2 groups according to the presence of diabetes mellitus. Read More

    A retrospective cohort survey of problems related to second childbirths during the 2-child policy period in Jiangbei District of Ningbo City in China.
    Medicine (Baltimore) 2018 May;97(18):e0604
    From 1979 to 2014 in China, a 1-child policy was imposed to control population growth. During 2014 to 2015, families in which 1 spouse was only 1 child were eligible to apply for planning a second child. To foresee issues affecting obstetrical departments related to the introduction of the universal 2-child policy in 2016, we retrospectively investigated the demographics and health-related outcomes of second pregnancies in families applying for a second child in Jiangbei District of Ningbo City during January 17, 2014, to January 14, 2016. Read More

    Obesity, gestational diabetes and macrosomia are associated with increasing rates of early-term induction of labour at The Canberra Hospital.
    Aust N Z J Obstet Gynaecol 2018 May 2. Epub 2018 May 2.
    Australian National University Medical School, The Canberra Hospital, Canberra, ACT, Australia.
    Background: Early-term delivery is an important cause of short-term neonatal morbidity and associated high healthcare costs, with possible additional long-term developmental ramifications. As a form of 'iatrogenic' delivery, induction of labour (IOL) is a potentially modifiable contributor to this burden.

    Aims: To determine patterns of, and primary indication for, early-term IOL, as well as temporal trends in this primary indication and differences from other modes of delivery with respect to maternal factors and maternal/neonatal outcomes. Read More

    Comparison of placental three-dimensional power Doppler indices and volume in the first and second trimesters of pregnancy complicated by gestational diabetes mellitus.
    J Matern Fetal Neonatal Med 2018 May 1:1-181. Epub 2018 May 1.
    a Department of Medicine , Mackay Medical College , New Taipei City , Taiwan.
    Objective: To compare the changes of placental three-dimensional power Doppler indices and volume in the first and second trimesters of pregnancy with gestational diabetes mellitus (GDM).

    Methods: This was a prospective case-control study of singleton pregnancies with risk factors for GDM. Data on placental vascular indices including vascularization index (VI), flow index (FI), and vascularization flow index (VFI), as well as placental volume were obtained and analyzed during the first and second trimesters between pregnant women with and without GDM. Read More

    Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial.
    JAMA 2018 05;319(17):1773-1780
    Centre for Research in Epidemiology and Population Health, Université Paris-Saclay, Université Paris-Sud, Université de Versailles Saint-Quentin-en-Yvelines, INSERM, Villejuif, France.
    Importance: Randomized trials have not focused on neonatal complications of glyburide for women with gestational diabetes.

    Objective: To compare oral glyburide vs subcutaneous insulin in prevention of perinatal complications in newborns of women with gestational diabetes.

    Design, Settings, And Participants: The Insulin Daonil trial (INDAO), a multicenter noninferiority randomized trial conducted between May 2012 and November 2016 (end of participant follow-up) in 13 tertiary care university hospitals in France including 914 women with singleton pregnancies and gestational diabetes diagnosed between 24 and 34 weeks of gestation. Read More

    Diabetes During Pregnancy: Surveillance, Preconception Care, and Postpartum Care.
    J Womens Health (Larchmt) 2018 May 1;27(5):536-541. Epub 2018 May 1.
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention , Atlanta, Georgia .
    Diabetes during pregnancy can adversely affect the health of women and infants. In this report, we provide an overview of the state of the science, and highlight Centers for Disease Control and Prevention (CDC) activities related to (1) surveillance of preexisting and gestational diabetes mellitus (GDM); (2) preconception care for women with preexisting diabetes; (3) postpartum diabetes screening among women with GDM-affected pregnancies; and (4) preventing the progression to Type 2 diabetes among women with GDM-affected pregnancies through lifestyle intervention programs. Improving preconception care, increasing postpartum diabetes screening rates, and promoting lifestyle interventions in the postpartum period all provide opportunities to improve the health of women and their infants. Read More

    Does pregnancy interval after laparoscopic sleeve gastrectomy affect maternal and perinatal outcomes?
    J Matern Fetal Neonatal Med 2018 May 17:1-7. Epub 2018 May 17.
    c Department of Obstetrics and Gynecology , SB Istanbul Medeniyet University Goztepe Education and Research Hospital , Istanbul , Turkey.
    Background: Obesity is a global health epidemic and is associated with many maternal and neonatal complications. Laparoscopic sleeve gastrectomy (LSG) is among the surgical treatments for obesity. The appropriate timing of pregnancy following LSG remains controversial and few studies have evaluated this public health issue. Read More

    Reduced Cortical Excitability, Neuroplasticity, and Salivary Cortisol in 11-13-Year-Old Children Born to Women with Gestational Diabetes Mellitus.
    EBioMedicine 2018 Apr 10. Epub 2018 Apr 10.
    Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5006, Australia. Electronic address:
    Background: Children exposed to gestational diabetes mellitus (GDM) in utero are at increased risk of neurodevelopmental difficulties, including autism and impaired motor control. However, the underlying neurophysiology is unknown.

    Methods: Using transcranial magnetic stimulation, we assessed cortical excitability, long-term depression (LTD)-like neuroplasticity in 45 GDM-exposed and 12 control children aged 11-13 years. Read More

    Risk factors for adverse maternal and perinatal outcomes in women with preeclampsia: analysis of 1396 cases.
    J Clin Hypertens (Greenwich) 2018 Apr 30. Epub 2018 Apr 30.
    Department of Obstetrics, Xiangya Hospital, Central South University, Changsha, China.
    Preeclampsia is a major cause of adverse maternal and perinatal outcomes, but how to identify women and fetuses at increased risk for later adverse events is a challenge. This study aimed to investigate the risk factors for adverse maternal and perinatal outcomes in women with preeclampsia. Data from 1396 women with preeclampsia were retrospectively collected and analyzed. Read More

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