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    Negative impact of hyperglycaemia on mouse alveolar development.
    Cell Cycle 2017 Nov 16:1-42. Epub 2017 Nov 16.
    b Division of Histology & Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education , Medical College , Jinan University , Guangzhou 510632 , China.
    Diabetes mellitus in pregnancy has been known to affect the embryonic development of various systems, including cardiovascular and nervous systems. However, whether this disease could have a negative impact on embryonic respiratory system remains controversial. In this study, we demonstrated that pregestational diabetes mellitus (PGDM)-induced defects in lung development in mice are mainly characterized by the changes in the morphological structure of the lung. Read More

    Successful glycemic control using a flash glucose monitoring system for a pregnant woman with diabetes: a case report.
    J Diabetes Metab Disord 2017 6;16:44. Epub 2017 Nov 6.
    Clinical Research Center, Department of Medicine, International University of Health and Welfare, Tokyo, Japan.
    Background: Glucose control for pregnant women with glucose intolerance is important, as hyperglycemia may adversely affect the mother and the fetus.

    Case Presentation: We report the case of a pregnant Japanese woman who experienced gestational diabetes mellitus during her first pregnancy and developed impaired glucose tolerance after the delivery. During her second pregnancy with twins, she required up to 75 units of injected insulin to control her postprandial hyperglycemia and occasionally experienced hypoglycemia. Read More

    Prevention of Insulin Resistance by Dietary Intervention among Pregnant Mothers: A Randomized Controlled Trial.
    Int J Prev Med 2017 24;8:85. Epub 2017 Oct 24.
    Department of Midwifery, Nursing and Midwifery School, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Chronic insulin resistance (IR) is a basic part of the pathophysiology of gestational diabetes mellitus. Nutrition significantly impacts IR and weight loss reduces insulin levels, whereas weight gain increases the concentrations. Therefore, we surveyed the effect of nutrition intervention on IR in pregnant women and whether this effect is irrespective of weight gaining in accordance with Institute of Medicine limits. Read More

    Delivery outcomes of large-for-gestational-age newborns stratified by the presence or absence of gestational diabetes mellitus.
    Int J Gynaecol Obstet 2017 Nov 15. Epub 2017 Nov 15.
    Lis Maternity and Women's Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
    Objective: To evaluate separate and combined contributions of gestational diabetes mellitus (GDM) and large-for-gestational age (LGA) on delivery outcomes.

    Methods: In a retrospective cohort study of term singleton deliveries between 2007 and 2014 in Tel Aviv, Israel, outcomes were compared between non-GDM/AGA pregnancies (reference) and three study groups: non-GDM/LGA, GDM/appropriate for gestational age (AGA) and GDM/LGA.

    Results: Overall, there were 62 102 deliveries, of which 53 201 (85. Read More

    Assessing the consequences of gestational diabetes mellitus on offspring's cardiovascular health: MySweetHeart Cohort study protocol, Switzerland.
    BMJ Open 2017 Nov 14;7(11):e016972. Epub 2017 Nov 14.
    Paediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
    Introduction: Gestational diabetes mellitus (GDM) is a state of glucose intolerance with onset during pregnancy. GDM carries prenatal and perinatal risks as well as long-term risks for the mother and her child. GDM may be involved in the foetal programming of long-term cardiovascular health. Read More

    Investigating antenatal nutrition education preferences in South-East Queensland, including Maori and Pasifika women.
    Women Birth 2017 Nov 11. Epub 2017 Nov 11.
    Nutrition and Dietetics, Logan Hospital, Metro South Health, Meadowbrook, Queensland 4131, Australia; Griffith University, School of Allied Health Sciences, Gold Coast Campus, Queensland 4222, Australia.
    Background: Little is reported about the nutrition-related needs and preferences of women seeking maternity services, particularly Maori and Pasifika (M&P) women who have higher chronic disease rates in Queensland.

    Aim: Nutrition-related knowledge, needs, behaviours and education preferences were compared between women of M&P ancestry and non-Maori and Pasifika women (NMP).

    Method: Women (≥18 years) admitted to the postnatal ward were surveyed. Read More

    Normalized Weight of Iranian Newborns According to Gestational Age: A Nationwide Study.
    Arch Iran Med 2017 Oct;20(10):626-632
    Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
    Background: By organizing birth weights according to gestational age at birth, reference weight values for different sex-gestational ages are provided.

    Methods: Data of 1,090,779 mothers and their neonates were gathered from 30 provinces of Iran. Pregnancy complications, maternal risk factors, type of delivery, maternal outcome, neonatal sex and APGAR score were determined. Read More

    Exposure to Perfluoroalkyl Substances and Metabolic Outcomes in Pregnant Women: Evidence from the Spanish INMA Birth Cohorts.
    Environ Health Perspect 2017 11 13;125(11):117004. Epub 2017 Nov 13.
    ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
    Background: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility.

    Objective: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women. Read More

    [Relationship between serum 25(OH)D levels at birth and respiratory distress syndrome in preterm infants].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Nov;19(11):1134-1137
    Department of Neonatology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, China.
    Objective: To investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels at birth and respiratory distress syndrome (RDS) in preterm infants.

    Methods: This retrospective study recruited preterm infants with gestational age of below 34 weeks who were born between January 2014 and December 2016. These preterm infants were divided into two groups: RDS (n=72) and control (n=40). Read More

    Weight gain in early pregnancy and risk of gestational diabetes mellitus among Latinas.
    Diabetes Metab 2017 Nov 9. Epub 2017 Nov 9.
    401 Arnold House, Department of Biostatistics & Epidemiology, School of Public Health & Health Sciences, University of Massachusetts, 715, North Pleasant Street, Amherst, MA 01003, United States. Electronic address:
    Aim: To evaluate the association between gestational weight gain (GWG) in early pregnancy and incidence of abnormal glucose tolerance (AGT) and gestational diabetes mellitus (GDM) among Latinas.

    Methods: We conducted a retrospective cohort study of 2039 Latinas using pooled data from two medical centres in Massachusetts. Gestational weights were abstracted from medical records and GWG was categorized as low, appropriate and excessive according to 2009 Institute of Medicine Guidelines. Read More

    Combined diet and exercise interventions for preventing gestational diabetes mellitus.
    Cochrane Database Syst Rev 2017 Nov 13;11:CD010443. Epub 2017 Nov 13.
    ARCH: Australian Research Centre for Health of Women and Babies, Robinson Research Institute, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, South Australia, Australia, 5006.
    Background: Gestational diabetes mellitus (GDM) is associated with a wide range of adverse health consequences for women and their infants in the short and long term. With an increasing prevalence of GDM worldwide, there is an urgent need to assess strategies for GDM prevention, such as combined diet and exercise interventions. This is an update of a Cochrane review that was first published in 2015. Read More

    Vitamin D receptor (VDR) polymorphisms are associated to spontaneous preterm birth and maternal aspects.
    Gene 2017 Nov 8. Epub 2017 Nov 8.
    Department of Genetics, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife, Pernambuco, Brazil. Electronic address:
    Preterm birth (PTB) is featured by less than 37weeks of gestational age or fewer than 259days since the first day from the last menstrual period. Complications of PTB are the major cause of neonatal deaths, several factors are linked to PTB increased risk including immunological and genetics. Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy. Read More

    Association Between Gestational Diabetes and Incident Maternal CKD: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
    Am J Kidney Dis 2017 Nov 8. Epub 2017 Nov 8.
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
    Background: Gestational diabetes mellitus (GDM) is associated with increased risk for diabetes mellitus, metabolic syndrome, and cardiovascular disease. We evaluated whether GDM is associated with incident chronic kidney disease (CKD), controlling for prepregnancy risk factors for both conditions.

    Study Design: Prospective cohort. Read More

    Very tight versus tight control: which should be the criteria for pharmacologic therapy dose adjustment in diabetes in pregnancy? Evidence from randomized controlled trials.
    Acta Obstet Gynecol Scand 2017 Nov 10. Epub 2017 Nov 10.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.
    Introduction: There is inconclusive evidence from randomized controlled trials (RCTs) to support any specific criteria for pharmacologic therapy dose adjustment in diabetes in pregnancy. Our objective was to analyze the criteria for dose adjustment of pharmacologic treatment for diabetes mellitus (DM) in pregnancy.

    Material And Methods: Data sources: MEDLINE, OVID and Cochrane Library were searched from their inception to September 2017. Read More

    Adiponectin Concentration in Gestational Diabetic Women: a Case-Control Study.
    Clin Nutr Res 2017 Oct 27;6(4):267-276. Epub 2017 Oct 27.
    Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
    Gestational diabetes mellitus (GDM) is an impaired fasting glucose condition during pregnancy. Adiponectin is a polypeptide hormone that is extensively released by adipocytes which regulates energy homeostasis and carbohydrate and lipid metabolism. In addition, adiponectin has antidiabetic and anti-inflammatory properties. Read More

    Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes.
    Diabetes Care 2017 Nov 9. Epub 2017 Nov 9.
    Centre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland, U.K.
    Objective: This study was conducted to determine the utility of tubular (urinary/plasma neutrophil gelatinase-associated lipocalin [NGAL] and urinary kidney injury molecule 1 [KIM-1]) and glomerular (estimated glomerular filtration rate [eGFR]) biomarkers in predicting preeclampsia (PE) in pregnant women with type 1 diabetes mellitus (T1DM) who were free of microalbuminuria and hypertension at the first trimester.

    Research Design And Methods: This was a prospective study of T1DM pregnancy. Maternal urinary and plasma NGAL urinary KIM-1 (ELISA of frozen samples), and eGFR (Chronic Kidney Disease Epidemiology Collaboration equation) were determined at three study visits (V1: 12. Read More

    Fetal overgrowth in women with type 1 and type 2 diabetes mellitus.
    PLoS One 2017 9;12(11):e0187917. Epub 2017 Nov 9.
    Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö, Sweden.
    Objectives: Despite improved glycemic control, the rate of large-for-gestational-age (LGA) infants remains high in pregnancies complicated by diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Poor glycemic control, obesity, and excessive gestational weight gain are the main risk factors. The aim of this study was to determine the relative contribution of these risk factors for LGA in women with T1DM and T2DM, after controlling for important confounders such as age, smoking, and parity. Read More

    History of mood or anxiety disorders and risk of gestational diabetes mellitus in a population-based cohort.
    Diabet Med 2017 Nov 9. Epub 2017 Nov 9.
    Department of Medicine, University of Alberta, Edmonton.
    Aim: To examine the association between mood and anxiety disorders and the development of gestational diabetes mellitus in a retrospective population-based cohort study.

    Methods: Clinical data from a provincial perinatal health registry were linked to physician claims, hospitalization records and emergency visits to identify any diagnoses of mood or anxiety disorders in the 2 years prior to pregnancy and a subsequent diagnosis of gestational diabetes during pregnancy. The study population included all singleton pregnancies in the Canadian province of Alberta from 1 April 2000 to 31 March 2010. Read More

    Effect of maternal smoking on stress physiology in healthy neonates.
    J Perinatol 2017 Nov 9. Epub 2017 Nov 9.
    Division of Obstetrics, Kantonsspital Baden, Baden, Switzerland.
    Objective: To assess the impact of maternal smoking during pregnancy (MSDP) on the neonatal hypothalamic-pituitary-adrenal axis.

    Study Design: In a prospective observational study, salivary cortisol and cortisone levels were measured at the fourth day of life during resting conditions and in response to a pain-induced stress event in healthy neonates whose mothers smoked cigarettes during each stage of pregnancy and compared with controls.

    Results: Neonates in the control group (n=70) exhibited a physiologic stress response with a significant increase in cortisol (1. Read More

    [Indirect causes of maternal deaths (except stroke, cardiovascular diseases and infections): Results from the French confidential enquiry into maternal deaths, 2010-2012].
    Gynecol Obstet Fertil Senol 2017 Nov 4. Epub 2017 Nov 4.
    Maternité les vallées, département de gynécologie obstétrique, hôpital privé d'Antony, 1, rue Velpeau, 92160 Antony, France.
    Maternal deaths of indirect causes result of a preexisting disease or an affection appeared during the pregnancy without any relationship with obstetrical causes, but worsened by the physiological effects of pregnancy. Among the 23 deaths of indirect cause related to a preexisiting pathology, 22 (96 %) have been analyzed by the expert comity. A known or preexisting chronic disease was documented in 16 patients (sick-cell disorder, n=3, treated epilepsy, n=3, intracerebral carvenomas, n=1, multifocal glial tumor, n=1, breast cancer, n=1, systemic lupus, n=1, diabetes mellitus, n=3, antiphospholipid syndrome, n=1). Read More

    High Neonatal Blood Iron Content Is Associated with the Risk of Childhood Type 1 Diabetes Mellitus.
    Nutrients 2017 Nov 6;9(11). Epub 2017 Nov 6.
    Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Paediatrics, Herlev University Hospital, 2730 Herlev, Denmark.
    (1) Background: Iron requirement increases during pregnancy and iron supplementation is therefore recommended in many countries. However, excessive iron intake may lead to destruction of pancreatic β-cells. Therefore, we aim to test if higher neonatal iron content in blood is associated with the risk of developing type 1 diabetes mellitus (T1D) in childhood; (2) Methods: A case-control study was conducted, including 199 children diagnosed with T1D before the age of 16 years from 1991 to 2005 and 199 controls matched on date of birth. Read More

    Maternal Diabetes Mellitus and Genital Anomalies in Male Offspring: A Nationwide Cohort Study in two Nordic Countries.
    Epidemiology 2017 Nov 6. Epub 2017 Nov 6.
    1Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark 2Perinatal Epidemiology Research Unit, Department of Child and Adolescent Health, Aarhus University Hospital, Aarhus, Denmark 3Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark 4Clinical Epidemiology Unit, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden 5Department of Public Health, Section for Biostatistics, Aarhus University, Aarhus, Denmark.
    Background: Diabetes in pregnancy has been associated with an increased risk of congenital malformations overall, but studies on genital anomalies in boys are conflicting and possible causal mechanisms are not well understood. Previous studies have mainly assessed pre-gestational and gestational diabetes in combination. Yet considering the vulnerable time windows for the genital anomalies, associations could well differ between types of diabetes and between the two genital anomalies and we therefore aimed to study this further. Read More

    Vascular-derived connective tissue growth factor (Ctgf) is critical for pregnancy-induced β cell hyperplasia in adult mice.
    Islets 2017 Nov 7:e1356963. Epub 2017 Nov 7.
    a Department of Medicine , Vanderbilt University Medical Center , Nashville , TN , USA.
    During pregnancy, maternal β cells undergo compensatory changes including hypertrophy, hyperplasia, and increased glucose-stimulated insulin secretion (GSIS). Failure of these adaptations to occur can result in gestational diabetes mellitus. The secreted protein, Connective tissue growth factor (Ctgf), is critical for normal β cell development and promotes regeneration after partial β cell ablation. Read More

    Long non-coding RNA MALAT1 expression in patients with gestational diabetes mellitus.
    Int J Gynaecol Obstet 2017 Nov 6. Epub 2017 Nov 6.
    Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, China.
    Objective: To monitor expression of long non-coding RNAs (lncRNAs) and changes in metabolic profiles among patients with gestational diabetes mellitus (GDM).

    Methods: A retrospective case-control study was conducted using data for women treated at a hospital in China between October 8, 2014, and April 15, 2015. The cases were women diagnosed with GDM using an oral glucose tolerance test at 24-28 weeks of pregnancy (n=50). Read More

    Mesenchymal stromal cells isolated from gestationally diabetic human placenta exhibit insulin resistance, decreased clonogenicity and angiogenesis.
    Placenta 2017 Nov 5;59:1-8. Epub 2017 Sep 5.
    School of Regenerative Medicine, Manipal University, MAHE, GKVK Post, Bellary Road, Allalasandra, Near Royal Orchid, Yelahanka, 560 065 Bangalore, India. Electronic address:
    Pregnancy is known to be a diabetogenic state. With sedentary lifestyle and wrong dietary choices, gestational diabetes mellitus is on the rise. This raises a concern as placenta is becoming an acceptable choice, as a source of Mesenchymal Stromal Cells (MSCs). Read More

    Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy.
    J Diabetes Res 2017 14;2017:5947859. Epub 2017 Sep 14.
    Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, 8330024 Santiago, Chile.
    Insulin resistance is characteristic of pregnancies where the mother shows metabolic alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or abnormal maternal conditions such as pregestational maternal obesity (PGMO). Insulin signalling includes activation of insulin receptor substrates 1 and 2 (IRS1/2) as well as Src homology 2 domain-containing transforming protein 1, leading to activation of 44 and 42 kDa mitogen-activated protein kinases and protein kinase B/Akt (Akt) signalling cascades in the human foetoplacental vasculature. PE, GDM, and PGMO are abnormal conditions coursing with reduced insulin signalling, but the possibility of the involvement of similar cell signalling mechanisms is not addressed. Read More

    Risk of abnormal fetal growth in women with early- and late-onset preeclampsia.
    Pregnancy Hypertens 2017 Sep 11. Epub 2017 Sep 11.
    Department of Physical Medicine and Rehabilitation, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan.
    Objectives: To investigate the risks of delivering small-for-gestational-age (SGA) and large-for-gestational-age (LGA) infants in women with early- (delivered before 34weeks of gestation) and late-onset (delivered at or after 34weeks of gestation) preeclampsia.

    Study Design: We conducted a retrospective cohort study of 29,494 singleton deliveries after 24weeks' gestation, excluding pregnancies complicated by fetal anomalies, stillbirths, and prepregnancy diabetes mellitus. Univariate and multivariate logistic analyses adjusted for potential confounding factors, including prepregnancy body mass index (BMI), gestational weight gain (GWG), and gestational diabetes mellitus (GDM), were performed. Read More

    Insulin for the treatment of women with gestational diabetes.
    Cochrane Database Syst Rev 2017 Nov 5;11:CD012037. Epub 2017 Nov 5.
    Liggins Institute, The University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.
    Background: Gestational diabetes mellitus (GDM) is associated with short- and long-term complications for the mother and her infant. Women who are unable to maintain their blood glucose concentration within pre-specified treatment targets with diet and lifestyle interventions will require anti-diabetic pharmacological therapies. This review explores the safety and effectiveness of insulin compared with oral anti-diabetic pharmacological therapies, non-pharmacological interventions and insulin regimens. Read More

    Assessment of novel cardiovascular biomarkers in women with a history of recurrent miscarriage.
    Pregnancy Hypertens 2017 Oct 28. Epub 2017 Oct 28.
    Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands; Division Women and Baby, Department of Obstetrics, Birth Centre, University Medical Centre Utrecht, Utrecht, The Netherlands.
    Objectives: A history of recurrent miscarriage is associated with future cardiovascular disease. The aim of this study was to determine novel cardiovascular biomarkers in women with a history of recurrent miscarriage as this might lead to a better understanding of the association.

    Study Design: Women who visited the recurrent miscarriage clinic at Leiden University Medical Centre (between 2000 and 2010), and had three consecutive miscarriages ≤30 years were invited to participate in this follow-up study (between 2012 and 2014). Read More

    Metformin as a prophylactic treatment of gestational diabetes in pregnant patients with pregestational insulin resistance: A randomized study.
    J Obstet Gynaecol Res 2017 Nov 2. Epub 2017 Nov 2.
    Department of Obstetrics and Gynecology, Hospital Barros Luco Trudeau, Santiago, Chile.
    Aim: We aimed to assess the use of metformin (MTF) in the prevention of gestational diabetes mellitus (GDM) in patients with pregestational insulin resistance (PIR).

    Methods: A double blind, multicenter, randomized trial was carried out in patients with a history of PIR and pregestational MTF treatment. Groups were allocated either to MTF 1700 mg/day or placebo. Read More

    Hypertensive disorders of pregnancy: a strong risk factor for subsequent hypertension 5 years after delivery.
    Hypertens Res 2017 Nov 2. Epub 2017 Nov 2.
    Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
    Hypertensive disorders of pregnancy are known to be a risk factor for future cardiovascular diseases. In contrast, there is a paucity of data on the not so distant future prognosis of hypertensive disorders of pregnancy. In the present study, we evaluated the incidence of the diseases causing cardiovascular problems (hypertension, diabetes mellitus, dyslipidemia and metabolic syndrome) 5 years after delivery in Japanese women with hypertensive disorders of pregnancy. Read More

    Reprioritizing life: a conceptual model of how women with type 1 diabetes deal with main concerns in early motherhood.
    Int J Qual Stud Health Well-being 2017 ;12(sup2):1394147
    b Centre for Person-Centered Care (GPCC) , Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
    Purpose: Becoming a mother is related to increased demands for women with type 1 diabetes mellitus, and more research is needed to identify their needs for support in everyday living. Thus, the aim of this study was to explore the main concerns in daily life in early motherhood for women with type 1 diabetes and how they deal with these concerns.

    Method: A grounded theory study was conducted in which 14 women with type 1 diabetes were interviewed individually 7 to 17 months after childbirth. Read More

    Are women positive for the One Step but negative for the Two Step screening tests for gestational diabetes at higher risk for adverse outcomes?
    Acta Obstet Gynecol Scand 2017 Nov 1. Epub 2017 Nov 1.
    Division of Maternal-Fetal Medicine Department of Obstetrics and Gynecology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.
    Introduction: To evaluate if women meeting criteria for gestational diabetes mellitus (GDM) by the One Step test as per International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria but not by other less strict criteria have adverse pregnancy outcomes compared to GDM negative controls. The primary outcome was the incidence of macrosomia, defined as birth weight >4,000 grams.

    Material And Methods: Electronic databases were searched from their inception until May 2017. Read More

    Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia.
    Oncotarget 2017 Sep 8;8(43):75254-75263. Epub 2017 Sep 8.
    International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
    Background: Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of diabetes in offspring. However, the mechanisms involved in the insulin resistance in offspring are still unclear. Mitochondrial dysfunction is related with insulin resistance. Read More

    Intergenerational diabetes and obesity-A cycle to break?
    PLoS Med 2017 Oct 31;14(10):e1002415. Epub 2017 Oct 31.
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Ronald Ma and Barry Popkin discuss the urgent need and challenges to reduce intergenerational transmission of obesity and diabetes. Read More

    An early-customized low glycaemic-index diet prevents adverse pregnancy outcomes in overweight/obese women.
    Minerva Ginecol 2017 Oct 27. Epub 2017 Oct 27.
    Obstetric Unit, Mother-Infant Department, Policlinico Hospital, University of Modena and Reggio Emilia, Modena, Italy -
    Objective: To determine whether the prescription and follow-up of a behavioral program (customized nutritional advices and a constant physical activity) influences the occurrence of unfavorable maternal/neonatal outcomes among overweight/obese women.

    Methods: A case-control study (1:3) included single pregnant women with BMI≥25, enrolled at 1st trimester. Cases (95) were prescribed (by both the dietitian and gynecologist) a low-glycemic index diet with an average intake of 1700/1800 Kcal/day plus 30 minutes walking at least 3 times/week (with four follow-up visits until delivery). Read More

    Evaluation of late adolescent pregnancies: Is late adolescence a risk factor for preterm labor?
    J Matern Fetal Neonatal Med 2017 Oct 29:1-6. Epub 2017 Oct 29.
    a Department of Obstetrics and Gynaecology, Faculty of Medicine , Marmara University , Maltepe, Istanbul , Turkey.
    Study Objective: We evaluated effect of late adolescence during pregnancy and its confounding factors on neonatal and maternal results.

    Objective: The aim of the present study is to evaluate the effect of late adolescence on maternal, perinatal outcomes and preterm labor.

    Methods: This retrospective study was carried out on 172 late adolescents and 160 adult women who delivered in a tertiary center. Read More

    Effect of metformin on maternal and neonatal outcomes in pregnant obese non-diabetic women: A meta-analysis.
    Int J Reprod Biomed (Yazd) 2017 Aug;15(8):461-470
    Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Background: Metformin reduces maternal and neonatal weight gain in gestational diabetes mellitus; however, this effect is poorly investigated in non-diabetic women.

    Objective: We performed this meta-analysis to investigate the effect of metformin intake during pregnancy on maternal and neonatal outcomes in obese non-diabetic women.

    Materials And Methods: We searched Medline, EMBASE, and Cochrane CENTRAL for eligible randomized controlled trials addressing the efficacy of metformin in pregnant obese non-diabetic women. Read More

    Different methods and settings for glucose monitoring for gestational diabetes during pregnancy.
    Cochrane Database Syst Rev 2017 10 29;10:CD011069. Epub 2017 Oct 29.
    King Edward Memorial Hospital, Perth, Western Australia, Australia.
    Background: Incidence of gestational diabetes mellitus (GDM) is increasing worldwide. Blood glucose monitoring plays a crucial part in maintaining glycaemic control in women with GDM and is generally recommended by healthcare professionals. There are several different methods for monitoring blood glucose which can be carried out in different settings (e. Read More

    Gut microbiome in gestational diabetes: A Cross-sectional study of mothers and offspring 5 years post-partum.
    Acta Obstet Gynecol Scand 2017 Oct 27. Epub 2017 Oct 27.
    Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki.
    Introduction: An altered gut microbiome composition is shown to be associated with various diseases and health outcomes. We compare the gut microbiota of women who developed gestational diabetes mellitus (GDM) to those who did not, and the gut microbiota of their offspring, to determine any differences in the composition and diversity of their gut microbiota, which may be correlated with their GDM state.

    Material And Methods: All women were at high risk for GDM and participated in the Finnish Gestational Diabetes Prevention Study (RADIEL). Read More

    Effects of Late Gestational Fetal Exposure to Dexamethasone Administration on the Postnatal Hypothalamus-Pituitary-Adrenal Axis Response to Hypoglycemia in Pigs.
    Int J Mol Sci 2017 Oct 27;18(11). Epub 2017 Oct 27.
    Institute for Biochemistry II, Jena University Hospital-Friedrich Schiller University, 07743 Jena, Germany.
    Background: Prenatal glucocorticoid administration alters the activity of the fetal hypothalamic-pituitary-adrenocortical axis (HPAA), and correspondingly the adenocorticotropic hormone (ACTH) and cortisol levels after birth. The dosages required for these effects are critically discussed. Activation of the HPAA is related to metabolic syndrome and diabetes mellitus. Read More

    Obesity and gynaecological and obstetric conditions: umbrella review of the literature.
    BMJ 2017 Oct 26;359:j4511. Epub 2017 Oct 26.
    Department of Surgery and Cancer, IRDB, Faculty of Medicine, Imperial College, London W12 0NN, UK.
    Objective To study the strength and validity of associations between adiposity and risk of any type of obstetric or gynaecological conditions.Design An umbrella review of meta-analyses.Data sources PubMed, Cochrane database of systematic reviews, manual screening of references for systematic reviews or meta-analyses of observational and interventional studies evaluating the association between adiposity and risk of any obstetrical or gynaecological outcome. Read More

    External Validation Study of First Trimester Obstetric Prediction Models (Expect Study I): Research Protocol and Population Characteristics.
    JMIR Res Protoc 2017 Oct 26;6(10):e203. Epub 2017 Oct 26.
    Care and Public Health Research Institute (CAPHRI), Department of Epidemiology, Maastricht University, Maastricht, Netherlands.
    Background: A number of first-trimester prediction models addressing important obstetric outcomes have been published. However, most models have not been externally validated. External validation is essential before implementing a prediction model in clinical practice. Read More

    Dietary iron intake, iron status, and gestational diabetes.
    Am J Clin Nutr 2017 Oct 25. Epub 2017 Oct 25.
    Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
    Pregnant women are particularly vulnerable to iron deficiency and related adverse pregnancy outcomes and, as such, are routinely recommended for iron supplementation. Emerging evidence from both animal and population-based studies, however, has raised potential concerns because significant associations have been observed between greater iron stores and disturbances in glucose metabolism, including increased risk of type 2 diabetes among nonpregnant individuals. Yet, the evidence is uncertain regarding the role of iron in the development of gestational diabetes mellitus (GDM), a common pregnancy complication which has short-term and long-term adverse health ramifications for both women and their children. Read More

    Metformin in Gestational Diabetes Mellitus: predictors of poor response.
    Eur J Endocrinol 2017 Oct 25. Epub 2017 Oct 25.
    M Almeida, Department of Obstetrics, Coimbra Hospital and Universitary Centre, Coimbra, Portugal.
    Objective: Metformin can be regarded as a first-line treatment in Gestational Diabetes Mellitus (GDM) due to its safety and effectiveness. However, a proportion of women do not achieve adequate glycemic control with metformin alone. We aim to identify predictors of this poor response to metformin. Read More

    Metabolomics in gestational diabetes.
    Clin Chim Acta 2017 Oct 21;475:116-127. Epub 2017 Oct 21.
    Mass Spectrometry Centre, China-Canada-New Zealand Joint Laboratory of Maternal and Foetal Medicine, Chongqing Medical University, Chongqing, China; Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
    Gestational diabetes mellitus (GDM) is a form of diabetes that is first diagnosed during pregnancy in the absence of existing type 1 or type 2 diabetes. Early screening tools for GDM are currently unavailable, but metabolomics is a promising approach for detecting biomarkers of GDM. This review evaluates recent GDM studies employing metabolomic techniques, highlighting the challenges in those studies and envisions the future directions for metabolomic study of GDM. Read More

    Gestational diabetes mellitus and maternal breast cancer risk: a meta-analysis of the literature.
    J Matern Fetal Neonatal Med 2017 Nov 7:1-11. Epub 2017 Nov 7.
    e Division of Birth Cohort Study , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China.
    Objective: The association between gestational diabetes mellitus (GDM) and maternal breast cancer risk was controversial and inclusive. In this study, we aimed to examine the association between GDM and maternal breast cancer using meta-analysis method.

    Methods: Researchers searched and reviewed the topic related articles comprehensively. Read More

    Abnormal 1-hour post-load glycemia during pregnancy impairs post-partum metabolic status: a single-center experience.
    J Endocrinol Invest 2017 Oct 24. Epub 2017 Oct 24.
    Endocrinology Section, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Hospital, University of Catania, via Palermo 636, 95122, Catania, Italy.
    Purpose: Recent evidence indicates that people with normal glucose tolerance (NGT) but 1-h post-load plasma glucose (1-h OGTT) ≥ 155 mg/dl have an increased risk for developing Type 2 diabetes mellitus (T2DM), determining a new risk category with deeper metabolic impairment. The aim of this study was to identify, among women with gestational diabetes (GDM), which alterations at OGTT during pregnancy are more frequently associated with 1-h OGTT ≥ 155 mg/dl at post-partum examination.

    Methods: Among 297 women affected by GDM, we retrospectively evaluated 244 resulted NGT after delivery. Read More

    Exercise and its role in gestational diabetes mellitus.
    Chronic Dis Transl Med 2016 Dec 20;2(4):208-214. Epub 2016 Dec 20.
    Department of Obstetrics and Gynecology of Peking University First Hospital, Beijing 100034, China.
    Gestational diabetes mellitus (GDM) refers to diabetes diagnosed in the second or third trimester of pregnancy that is not clearly either type 1 or type 2 diabetes. GDM is a common medical complication in pregnancy that has been rapidly increasing worldwide. GDM is associated with both short- and long-term health issues for both mothers and offspring. Read More

    National study of the prevalence of gestational diabetes mellitus among Danish women from 2004 to 2012.
    Scand J Public Health 2017 Oct 1:1403494817736943. Epub 2017 Oct 1.
    1 Department of Public Health, Aarhus University, Denmark.
    Aims: The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. We studied the prevalence of GDM from 2004 to 2012 in Danish women aged 15-49 years using registries with records of the diagnosis of GDM at delivery.

    Methods: We conducted a national register-based study of 12,538 women with a diagnosis of GDM during a pregnancy leading to a live birth in the period 2004-2012. Read More

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