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    Vitrified-warmed single-embryo transfers may be associated with increased maternal complications compared with fresh single-embryo transfers.
    Reprod Biomed Online 2017 Apr 6. Epub 2017 Apr 6.
    Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada.
    Cryopreservation of embryos allows single-embryo transfer and storage of supernumerary embryos, maximizing cumulative pregnancy rates. The purpose of this retrospective cohort study was to compare pregnancy outcome in singletons born after fresh or vitrified-warmed single blastocyst transfer (SBT). Singleton live births resulting from SBT of fresh or vitrified-warmed embryos were compared. Read More

    Prenatal determinants of physical activity and cardiorespiratory fitness in adolescence - Northern Finland Birth Cohort 1986 study.
    BMC Public Health 2017 Apr 20;17(1):346. Epub 2017 Apr 20.
    Chronic Disease Prevention Unit, Department of Health, National Institute for Health and Welfare, Oulu and Helsinki, Finland.
    Background: Lower levels of physical activity and cardiorespiratory fitness are key risk factors of chronic adult diseases. Physical activity and cardiorespiratory fitness are predicted by birth weight, but the underlying parental and pregnancy-related factors remain largely unknown. We examined how prenatal determinants are associated with physical activity and cardiorespiratory fitness in adolescence. Read More

    Diabetic pregnancy, maternal and fetal docosahexaenoic acid: a review of existing evidence.
    J Matern Fetal Neonatal Med 2017 Apr 19:1-6. Epub 2017 Apr 19.
    a Faculté de médecine et des sciences de la santé, Université de Sherbrooke , Sherbrooke , Canada.
    Objective: Docosahexaenoic acid (DHA) is vital for fetal development especially during the third trimester of gestation when the speed of fetal brain growth is at its peak. Diabetes modifies the maternal fatty acid profile, which may in turn change the quantity and/or quality of lipids transferred to the fetus. Neonates born to diabetic mothers might be more vulnerable to DHA deficiency leading to lower cognitive scores together with lower overall intellectual quotients when compared to control. Read More

    Serum placental growth factor and soluble fms-like tyrosine kinase 1 at mid-gestation in healthy women: Association with small-for-gestational-age neonates.
    J Obstet Gynaecol Res 2017 Apr 19. Epub 2017 Apr 19.
    Department of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
    Aim: This study was performed to determine the associations between serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels at mid-gestation with the risk of small-for-gestational-age (SGA) neonates born at gestational week (GW) ≥ 36 in healthy women.

    Methods: PlGF and sFlt-1 concentrations were determined at GW 24-27 in 183 women with births at GW ≥ 36, but without gestational diabetes mellitus and hypertension.

    Results: Thirteen (7. Read More

    Breastfeeding after Gestational Diabetes: Does Perceived Benefits Mediate the Relationship?
    J Pregnancy 2017 22;2017:9581796. Epub 2017 Mar 22.
    Division of Epidemiology, Department of Family Medicine and Population Health, School of Medicine, Virginia Commonwealth University, 830 East Main Street, Suite 821, P.O. Box 980212, Richmond, VA 23298-0212, USA.
    Introduction. Breastfeeding is recognized as one of the best ways to decrease infant mortality and morbidity. However, women with gestational diabetes mellitus (GDM) may have breastfeeding barriers due to the increased risk of neonatal and pregnancy complications. Read More

    Gestational diabetes mellitus: Berlin and beyond.
    • Authors:
    J Pak Med Assoc 2017 Apr;67(4):641-644
    The Berlin Declaration is a landmark call to action, which encourages policy makers to take early action to halt the type 2 diabetes epidemic. It emphasizes the need for prevention, early detection, early control, and early access to the right interventions. We believe these four pillars of early action in type 2 diabetes are as relevant to gestational diabetes mellitus (GDM) and action in the latter will impact on the former. Read More

    Fasting plasma glucose and body mass index during the first trimester of pregnancy as predictors of gestational diabetes mellitus in a Chinese population.
    Endocr J 2017 Apr 14. Epub 2017 Apr 14.
    Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
    This retrospective study assessed fasting plasma glucose (FPG) and body mass index (BMI) during the first trimester of pregnancy as potential screening indicators of later gestational diabetes mellitus (GDM). The study population included 820 pregnant women who delivered in our hospital between 17 September 2013 and 3 March 2014. Demographics and baseline characteristics were collected at the first antenatal visit; FPG levels were measured at 8 or 9 weeks. Read More

    High insulin impaired ovarian function in early pregnant mice and the role of autophagy in this process.
    Endocr J 2017 Apr 18. Epub 2017 Apr 18.
    Laboratory of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China.
    Metabolic disorders, such as PCOS (polycystic ovarian syndrome) and T2DM (type 2 diabetes mellitus), are associated with menstrual dysfunction, anovulation, infertility, and early pregnancy loss. Ovarian dysfunction is not only related to low pregnancy rates but also to the increased risk of miscarriage. Women with PCOS or T2DM, characterized by hyperinsulinemia, commonly experience ovarian dysfunction. Read More

    Pregnancy and Labor Complications in Female Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study.
    J Natl Cancer Inst 2017 Nov;109(11)
    Affiliations of authors: Centre for Childhood Cancer Survivor Studies, Institute of Applied Health Research, Robert Aitken Building, University of Birmingham, Edgbaston, Birmingham, UK (RCR, CJB, DLW, MMF, KW, JG, JSK, CF, MMH); Department of Paediatric Haematology and Oncology, Royal Hospital for Sick Children, University of Edinburgh, Edinburgh, UK (ABE, WHBW); Department of Paediatric and Adolescent Haematology and Oncology, and Children's BMT Unit, Great North Children's Hospital, Royal Victoria Infirmary, Newcastle upon Tyne, UK (RS).
    Background: Female survivors of childhood cancer treated with abdominal radiotherapy who manage to conceive are at risk of delivering premature and low-birthweight offspring, but little is known about whether abdominal radiotherapy may also be associated with additional complications during pregnancy and labor. We investigated the risk of developing pregnancy and labor complications among female survivors of childhood cancer in the British Childhood Cancer Survivor Study (BCCSS).

    Methods: Pregnancy and labor complications were identified by linking the BCCSS cohort (n = 17 980) to the Hospital Episode Statistics (HES) for England. Read More

    Fetal Nasal Bone Length as a Novel Marker for Prediction of Adverse Perinatal Outcomes in the First-Trimester of Pregnancy.
    Balkan Med J 2017 Apr;34(2):127-131
    Clinic of Obstetrics and Gynaecology, Kent Hospital, İzmir, Turkey.
    Background: Adverse outcomes of pregnancy are a challenging health-care problem. Prediction of adverse pregnancy outcomes is important to prevent the morbidities of the foetus and the mother.

    Aims: To study the clinical interest of fetal nasal bone length in predicting adverse pregnancy outcomes in the first trimester of pregnancy. Read More

    Cardiorespiratory fitness and health-related quality of life in women at risk for gestational diabetes.
    Scand J Med Sci Sports 2017 Apr 17. Epub 2017 Apr 17.
    Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Finland.
    This study examined the associations of cardiorespiratory fitness (CRF) and leisure-time physical activity (LTPA) with health-related quality of life (HRQoL) in women at risk for gestational diabetes mellitus (GDM). The participants were 39 women planning pregnancy with a history of GDM and/or BMI > 29 kg·m(-2) . We assessed CRF by measuring maximal oxygen consumption (O2max ) during incremental cycle ergometer exercise until voluntary fatigue. Read More

    Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy.
    Clin Epigenetics 2017 13;9:37. Epub 2017 Apr 13.
    Diabetes and Metabolism, Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark.
    Background: Offspring of women with diabetes in pregnancy are at increased risk of type 2 diabetes mellitus (T2DM), potentially mediated by epigenetic mechanisms. The adipokines leptin, adiponectin, and resistin (genes: LEP, ADIPOQ, RETN) play key roles in the pathophysiology of T2DM. We hypothesized that offspring exposed to maternal diabetes exhibit alterations in epigenetic regulation of subcutaneous adipose tissue (SAT) adipokine transcription. Read More

    Effect of exercise during pregnancy to prevent gestational diabetes mellitus: a systematic review and meta-analysis.
    J Matern Fetal Neonatal Med 2017 Apr 14:1-12. Epub 2017 Apr 14.
    a Obstetrics and Gynecology Department , Fenghua people's hospital of Ningbo , Zhejiang , China.
    Introduction: Exercise showed some potential in preventing gestational diabetes mellitus. However, the results remained controversial. We conducted a systematic review and meta-analysis to evaluate the impact of exercise during pregnancy on gestational diabetes mellitus. Read More

    Use of placental vascularization indices and uterine artery peak systolic velocity in early detection of pregnancies complicated by gestational diabetes, chronic or gestational hypertension, and preeclampsia at risk.
    Croat Med J 2017 Apr;58(2):161-169
    Andrea Surányi, Semmelweis str. 1., Szeged, Csongrád, H-6725, Hungary,
    Aim: We aimed to investigate correlations between uterine artery peak systolic velocity (AUtPSV), and placental vascularization in groups of normal blood pressure (NBP) and hypertensive disorders of pregnancy (chronic hypertension (CHT), gestational hypertension (GHT) and preeclampsia (PE)) alone or in combination with gestational diabetes mellitus (GDM), and hypothesized that AUtPSV rises when GDM complicates pregnancy hypertension.

    Methods: Placental 3-dimensional power Doppler indices, such as vascularization index (VI), flow index (FI), and vascularization-flow index (VFI), and uterine artery peak systolic velocity (AUtPSV) were measured in CHT (N=43), CHT+GDM (N=15), GHT (N=57), GHT+GDM (N=23) and PE (N=17) pregnancies, and compared to NBP (N=109). Correlations were analyzed between vascularization indices, AUtPSV, pregestational BMI and adverse pregnancy outcome rates. Read More

    Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility.
    Croat Med J 2017 Apr;58(2):96-104
    Robert Gaspar, Eotvos Street 6., Szeged, H-6720, Hungary,
    Obesity is a global health problem even among pregnant women. Obesity alters quality of labor, such as preterm labor, prolonged labor, and higher oxytocin requirements in pregnant women. The most important factors to play a role in the altered gestational period and serve as drug targets to treat the consequences are female sexual hormones, calcium channels, adrenergic system, oxytocin, and prostaglandins. Read More

    A core outcome set for studies evaluating the effectiveness of prepregnancy care for women with pregestational diabetes.
    Diabetologia 2017 Apr 13. Epub 2017 Apr 13.
    Galway Diabetes Research Centre, Department of Medicine, National University of Ireland Galway, Galway, Ireland.
    Aims/hypothesis: The aim of this study was to develop a core outcome set (COS) for trials and other studies evaluating the effectiveness of prepregnancy care for women with pregestational (pre-existing) diabetes mellitus.

    Methods: A systematic literature review was completed to identify all outcomes reported in prior studies in this area. Key stakeholders then prioritised these outcomes using a Delphi study. Read More

    Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study.
    Cardiovasc Diabetol 2017 Apr 13;16(1):49. Epub 2017 Apr 13.
    School of Medicine, University of Tampere, Tampere, Finland.
    Background: Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother. Some clinical studies have suggested subclinical inflammation and vascular dysfunction after GDM. We aimed to study whether concentrations of high-sensitivity C-reactive protein (hsCRP), tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-8 (MMP-8) and -9, as well as values of arterial stiffness differ between women with and without a history of GDM a few years after delivery. Read More

    Peripheral Immunological Cells in Pregnant Women and their Change during Diabetes.
    Exp Clin Endocrinol Diabetes 2017 Apr 13. Epub 2017 Apr 13.
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Ulm, Ulm, Germany.
    During the last decades the incidence of diabetes has dramatically increased as well as the number of pregnant diabetic women. There is still missing data regarding patterns and shifts of immune cell populations due to pregnancy with or without diabetes. The study aimed to investigate the impact of pregnancy, type 1 diabetes (T1D) and gestational diabetes mellitus (GDM) on different immune cells in female. Read More

    Low Glycemic Index Prototype Isomaltulose-Update of Clinical Trials.
    Nutrients 2017 Apr 13;9(4). Epub 2017 Apr 13.
    Clinical Research Unit, Centre of Internal Medicine, Justus Liebig University, 35392 Giessen, Hesse, Germany.
    Low glycemic index diets are supposed to achieve a more beneficial effect on blood glucose control in people with diabetes mellitus and may also provide metabolic benefits for the general population. A prototype of a low-glycemic index carbohydrate is the natural occurring disaccharide isomaltulose that can be commercially produced from sucrose (beet sugar) to industrial scale. It is currently used in various food and drink applications as well as special and clinical nutrition feeds and formula diet as a food ingredient and alternative sugar. Read More

    Lower glycemic load meals reduce diurnal glycemic oscillations in women with risk factors for gestational diabetes.
    BMJ Open Diabetes Res Care 2017 29;5(1):e000351. Epub 2017 Mar 29.
    Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia; Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, The University of Sydney, Sydney, New South Wales, Australia.
    Objective: Maternal glycemia plays a key role in fetal growth. We hypothesized that lower glycemic load (GL) meals (lower glycemic index, modestly lower carbohydrate) would substantially reduce day-long glucose variability in women at risk of gestational diabetes mellitus (GDM).

    Research Design And Methods: A crossover study of 17 women (mean±SD age 34. Read More

    Postpartum glucose testing, related factors and progression to abnormal glucose tolerance in a rural population with a known history of gestational diabetes.
    Diabetes Metab Syndr 2017 Apr 3. Epub 2017 Apr 3.
    Faculty of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Abadan School of Medical Sciences, Abadan, Iran. Electronic address:
    Aims: Gestational diabetes is a strong risk factor for postpartum progression to glucose intolerance. The aims of the study were to determine rate of postpartum glucose testing , its related factors and rate of progression to glucose intolerance in women who underwent postpartum glucose testing after pregnancy that complicated by gestational diabetes.

    Materials: this is a retrospective study and women with gestational diabetes who received prenatal care during 2005-2015 in 3 rural health centers of Khuramshahr (southwestern of Iran) were enrolled. Read More

    Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus.
    Oxid Med Cell Longev 2017 16;2017:5629341. Epub 2017 Mar 16.
    Department of Obstetrics and Gynecology, Puerta del Mar University Hospital, Cádiz, Spain.
    Dysregulation of NO production is implicated in pregnancy-related diseases, including gestational diabetes mellitus (GDM). The role of NO and its placental targets in GDM pregnancies has yet to be determined. S-Nitrosylation is the NO-derived posttranslational protein modification that can modulate biological functions by forming NO-derived complexes with longer half-life, termed S-nitrosothiol (SNO). Read More

    Increased Oxidative Stress and Cytokinesis-block Micronucleus Cytome Assay Parameters in Pregnant Women with Gestational Diabetes Mellitus and Gestational Arterial Hypertension.
    Reprod Toxicol 2017 Apr 8. Epub 2017 Apr 8.
    Genetic Laboratory Department, Obstetrics and Gynecology Clinic "Narodni Front", Street Kraljice Natalije 62, 11000 Belgrade, Serbia.
    We investigated whether gestational diabetes mellitus (GDM) and gestational arterial hypertension (GH) are associated with increased oxidative stress and DNA damage. Study included 3 groups of pregnant women (GDM, GH and control). DNA damage biomarkers (micronuclei MNi, nucleoplasmic bridges NPBs and nuclear buds NBUDs) were assessed by cytokinesis-block micronucleus cytome assay. Read More

    Preconception care for women with type 1 or type 2 diabetes mellitus: a mixed-methods study exploring uptake of preconception care.
    Health Technol Assess 2017 Mar;21(14):1-130
    Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK.
    Background: Diabetes mellitus is a global health problem and one of the most common medical conditions in pregnancy. A wide range of modifiable risk factors are associated with diabetes mellitus in pregnancy, and it is widely acknowledged that preconception care (PCC) is beneficial for women with pre-existing diabetes mellitus. However, uptake of PCC services is low. Read More

    Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk-an exploratory study.
    Clin Epigenetics 2017 5;9:35. Epub 2017 Apr 5.
    Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
    Background: Prenatal environmental conditions may influence disease risk in later life. We previously found a gene-environment interaction between the paraoxonase 1 (PON1) Q192R genotype and prenatal pesticide exposure leading to an adverse cardio-metabolic risk profile at school age. However, the molecular mechanisms involved have not yet been resolved. Read More

    Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects.
    Proc Natl Acad Sci U S A 2017 Apr 10. Epub 2017 Apr 10.
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201.
    Diabetes mellitus in early pregnancy increases the risk in infants of birth defects, such as neural tube defects (NTDs), known as diabetic embryopathy. NTDs are associated with hyperglycemia-induced protein misfolding and Caspase-8-induced programmed cell death. The present study shows that misfolded proteins are ubiquitinylated, suggesting that ubiquitin-proteasomal degradation is impaired. Read More

    Early screening for type 2 diabetes following gestational diabetes mellitus in France: hardly any impact of the 2010 guidelines.
    Acta Diabetol 2017 Apr 9. Epub 2017 Apr 9.
    Service de Biostatistique et d'Informatique Médicale (DIM), CHRU Dijon, 21000, Dijon, France.
    Aims: Women who had gestational diabetes mellitus (GDM) have a high risk of type 2 diabetes mellitus (T2DM) in the years following pregnancy. Most follow-up screening studies have been conducted in limited geographical areas leading to large variability in the results. The aim of our investigation was to measure how the publication of guidelines affected early screening for T2DM after a pregnancy with GDM during the period 2007-2013, in France. Read More

    The Challenges and Recommendations for Gestational Diabetes Mellitus Care in India: A Review.
    Front Endocrinol (Lausanne) 2017 24;8:56. Epub 2017 Mar 24.
    FSRC (a Part of phamax) , Bangalore , India.
    Gestational diabetes mellitus (GDM) is a primary concern in India affecting approximately five million women each year. Existing literature indicate that prediabetes and diabetes affect approximately six million births in India alone, of which 90% are due to GDM. Studies reveal that there is no consensus among physicians and health-care providers in India regarding management of GDM prepartum and postpartum despite available guidelines. Read More

    Carbohydrate Counting during Pregnancy in Women with Type 1 Diabetes: Are There Predictable Changes That We Should Know?
    Ann Nutr Metab 2017 Apr 8;70(2):140-146. Epub 2017 Apr 8.
    Federal University of Rio de Janeiro, Maternity-School of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
    Background/aims: Carbohydrate counting (CC) is a helpful strategy for the treatment of type 1 diabetes mellitus (T1DM) and the main parameters used in this method are the insulin to carbohydrate ratio (ICR) and the sensitivity factor (SF). Throughout pregnancy, a state of insulin resistance develops. Therefore, we hypothesized that ICR and SF change and our aim was to describe the pattern of modification of these parameters in pregnant women with T1DM on CC. Read More

    Gestational diabetes mellitus and first-trimester pregnancy-associated plasma protein-A: a case-control study in a Chinese population.
    J Diabetes Investig 2017 Apr 7. Epub 2017 Apr 7.
    Department of Obstetrics and Gynecology, Maternal and Child Healthcare Hospital of Shenzhen City, Southern Medical University, Shenzhen, Guangdong, China.
    Aims: To investigate the relationship between pregnancy-associated plasma protein A (PAPP-A) and gestational diabetes mellitus (GDM) and to determine whether PAPP-A has improved value for predicting GDM in a Chinese population.

    Methods: Clinical data for 599 GDM patients and 986 unaffected pregnant women undergoing both antenatal examinations and delivery were retrospectively analyzed. First-trimester serum PAPP-A levels were compared between the groups. Read More

    Prevalence and Complications of Pregestational and Gestational Diabetes in Saudi Women: Analysis from Riyadh Mother and Baby Cohort Study (RAHMA).
    Biomed Res Int 2017 12;2017:6878263. Epub 2017 Mar 12.
    Department of Primary Health Care, High Institute of Public Health, Alexandria University, Alexandria, Egypt.
    The objectives of this study were to estimate the burden of diabetes and to explore the adverse pregnancy outcomes associated with pregestational diabetes mellitus (pre-GDM) and gestational diabetes mellitus (GDM) among the Saudi pregnant population. In this subcohort, we compared the maternal and the neonatal outcomes of diabetic women with pre-GDM and GDM to the outcomes of nondiabetic mothers who delivered during the same period. From the total cohort, 9723 women participated in this study. Read More

    Simple approach based on maternal characteristics and mean arterial pressure for the prediction of preeclampsia in the first trimester of pregnancy.
    J Perinat Med 2017 Apr 6. Epub 2017 Apr 6.
    Department of Nursing, Federal University of Ceará (UFC), Fortaleza, State of Ceará.
    Aim: To propose a simple model for predicting preeclampsia (PE) in the 1st trimester of pregnancy on the basis of maternal characteristics (MC) and mean arterial pressure (MAP).

    Methods: A prospective cohort was performed to predict PE between 11 and 13+6 weeks of gestation. The MC evaluated were maternal age, skin color, parity, previous PE, smoking, family history of PE, hypertension, diabetes mellitus and body mass index (BMI). Read More

    Interactions between General and Central Obesity in Predicting Gestational Diabetes Mellitus in Chinese Pregnant Women: A Prospective Population-Based Study in Tianjin, China.
    J Diabetes 2017 Apr 6. Epub 2017 Apr 6.
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
    Objective: To define cutoff points of body mass index and waist circumference for GDM and to check any additive interactions between high body mass index and high waist circumference for GDM in Chinese pregnant women.

    Methods: From 2010 to 2012, we recruited 17,803 women who registered at 4 to12 weeks of gestation in Tianjin, China. GDM was diagnosed by the International Association of Diabetes and Pregnancy Study Group's criteria at 24 to 28 weeks of gestation. Read More

    High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus.
    Clin Nutr 2017 Mar 24. Epub 2017 Mar 24.
    Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address:
    Background & Aims: B-vitamins and homocysteine may contribute to the development of gestational diabetes mellitus (GDM), but existing studies are inconsistent. We examined the cross-sectional associations of plasma folate, vitamins B6, B12, and homocysteine concentrations with GDM and glycemia in a sample of multi-ethnic Asian pregnant women.

    Methods: Plasma concentrations of folate, vitamins B6, B12, homocysteine and glucose were measured at 26-weeks' gestation in 913 pregnant women. Read More

    Maternal urinary phthalates and sex-specific placental mRNA levels in an urban birth cohort.
    Environ Health 2017 Apr 5;16(1):35. Epub 2017 Apr 5.
    Department of Environmental Health Sciences, Mailman School of Public Health, 722 W 168th Street, New York, NY, 10032, USA.
    Background: Prenatal urinary concentrations of phthalates in women participants in an urban birth cohort were associated with outcomes in their children related to neurodevelopment, autoimmune disease risk, and fat mass at 3,5,7, and 8 years of life. Placental biomarkers and outcomes at birth may offer biologic insight into these associations. This is the first study to address these associations with candidate genes from the phthalate and placenta literature, accounting for sex differences, and using absolute quantitation methods for mRNA levels. Read More

    Pregnancy-associated plasma protein-A is a stronger predictor for adverse cardiovascular outcomes after acute coronary syndrome in type-2 diabetes mellitus.
    Cardiovasc Diabetol 2017 Apr 5;16(1):45. Epub 2017 Apr 5.
    Clinical Atherosclerosis Research Lab, Division of Cardiology, University of Washington, Seattle, WA, USA.
    Background: The risk prediction of pregnancy-associated plasma protein-A (PAPP-A) for future cardiovascular (CV) events post acute coronary syndrome (ACS) in patients with type-2 diabetes mellitus (T2DM) was investigated in comparison to other risk factors.

    Methods: PAPP-A was measured at hospital admission in 320 consecutive ACS patients (136 with T2DM and 184 without). All patients were followed for 2 years for occurrence of CV death, non-fatal MI or stroke. Read More

    Effect of eicosapentaenoic acid and docosahexaenoic acid supplementation on C-peptide preservation in pregnant women with type-1 diabetes: randomized placebo controlled clinical trial.
    Eur J Clin Nutr 2017 Apr 5. Epub 2017 Apr 5.
    Referral Center for Diabetes in pregnancy Ministry of Health Republic of Croatia, Department of Obstetrics and Gynecology Clinical Hospital Center Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia.
    Background/objectives: Type-1 diabetes mellitus (T1DM) is caused by autoimmune insulitis. There are evidences that pregnancy and n-3 fatty acids exhibit suppressive effect on human inflammatory system.

    Subjects/methods: Ninety pregnant women with T1DM were included in the prospective randomized placebo controlled clinical trial. Read More

    MicroRNAs in Pregnancy and Gestational Diabetes Mellitus: Emerging Role in Maternal Metabolic Regulation.
    Curr Diab Rep 2017 May;17(5):35
    Department of Biochemistry, Universite de Sherbrooke, Sherbrooke, QC, Canada.
    Purpose Of The Review: This review focuses on the recent emergence of microRNAs (miRNAs) as metabolic and developmental regulators in pregnancy and their role in the development of gestational diabetes mellitus (GDM). MiRNAs are short and stable RNA sequences that repress protein synthesis through interference with messenger RNA translation.

    Recent Findings: The placenta produces numerous miRNAs with some of them being released in the maternal circulation. Read More

    Routine Use of Prophylactic Antibiotics during Laparoscopic Cholecystectomy Does Not Reduce the Risk of Surgical Site Infections.
    Surg Infect (Larchmt) 2017 Apr 4. Epub 2017 Apr 4.
    1 Department of General Surgery, Uludag University , Bursa, Turkey .
    Background: Laparoscopic cholecystectomy (LC) is the gold standard for the treatment of symptomatic gallbladder stones. As infections are rare in uncomplicated LC, it is widely accepted that prophylactic antibiotics need not be administered, and guidelines do not support routine antibiotic prophylaxis during elective LC. However, routine antibiotic prophylaxis for elective LC is still popular in many clinical settings. Read More

    Maternal Antihypertensive Medication Use and Congenital Heart Defects: Updated Results From the National Birth Defects Prevention Study.
    Hypertension 2017 May 3;69(5):798-805. Epub 2017 Apr 3.
    From the Congenital Malformations Registry, New York State Department of Health, Albany (S.C.F., A.R.V.Z., C.M.D., M.L.B.); Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY (A.R.V.Z., C.M.D., M.L.B.); Department of Epidemiology, School of Public Health, Boston University, MA (M.M.W.); Genetics Unit, MassGeneral Hospital for Children, Boston, MA (A.E.L.); Massachusetts Department of Public Health, Massachusetts Center for Birth Defects Prevention, Boston (A.E.L.); and Department of Epidemiology, College of Public Health, University of Iowa, Iowa City (P.A.R.).
    Previous NBDPS (National Birth Defects Prevention Study) findings from 1997 to 2003 suggested that maternal antihypertensive use was associated with congenital heart defects (CHDs). We re-examined associations between specific antihypertensive medication classes and specific CHDs with additional NBDPS data from 2004 to 2011. After excluding mothers missing hypertension information or who reported pregestational diabetes mellitus, a multiple birth, or antihypertensive use but no hypertension, we compared self-reported maternal exposure data on 10 625 CHD cases and 11 137 nonmalformed controls. Read More

    Preliminary screening of mutations in the glucokinase gene of Chinese patients with gestational diabetes.
    J Diabetes Investig 2017 Mar 30. Epub 2017 Mar 30.
    Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
    Introduction: Mutations in the glucokinase gene (GCK) are a pathogenetic cause of maturity-onset diabetes of the young (MODY). Studies have found that female patients with GCK-MODY often present with gestational diabetes during pregnancy. Our aim was to preliminarily assess the prevalence of mutations in the glucokinase gene in Chinese subjects with gestational diabetes MATERIALS AND METHODS: Chinese gestational subjects who underwent a 100 g oral glucose tolerance test in Peking Union Medical College Hospital (PUMCH) from July 2005 to May 2008 were retrospectively analyzed. Read More

    Pregnancy Outcomes Following Ulipristal Acetate Emergency Contraception Failure: A Report of Five Cases.
    Fetal Pediatr Pathol 2017 Apr 3:1-7. Epub 2017 Apr 3.
    a Department of Clinical Pharmacology and Toxicology , Izmir Atatürk Research Hospital , Izmir , Turkey.
    Introduction: The emergency contraceptive ulipristal acetate (UPA) 30 mg is increasingly used by women, but there is no published data on UPA exposure in pregnancy.

    Case Report: Here we describe five cases of unintended pregnancies following the use of UPA for emergency contraception. Of five pregnant women exposed to UPA, one decided to terminate the pregnancy for personal reasons. Read More

    Fine-particulate matter (PM2.5), a risk factor for rat gestational diabetes with altered blood glucose and pancreatic GLUT2 expression.
    Gynecol Endocrinol 2017 Apr 3:1-6. Epub 2017 Apr 3.
    c Department of Gynaecology and Obstetrics , The Second Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang Province , P. R. China , Wenzhou, China.
    Recent studies have shown an intriguing association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter2 (GLUT2) expression in a gestational diabetes mellitus (GDM) rat model. Read More

    Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial.
    Br J Nutr 2017 Apr 3:1-10. Epub 2017 Apr 3.
    1University of Otago,Wellington 6021,New Zealand.
    The study aims to assess whether supplementation with the probiotic Lactobacillus rhamnosus HN001 (HN001) can reduce the prevalence of gestational diabetes mellitus (GDM). A double-blind, randomised, placebo-controlled parallel trial was conducted in New Zealand (NZ) (Wellington and Auckland). Pregnant women with a personal or partner history of atopic disease were randomised at 14-16 weeks' gestation to receive HN001 (6×109 colony-forming units) (n 212) or placebo (n 211) daily. Read More

    [The myo-inositol is beneficial in the therapy of pregnancy with insulin-dependent type 2 diabetes and polycystic ovary syndrome].
    Orv Hetil 2017 Apr;158(14):541-545
    Megyei Diabétesz Gondozó, Tolna Megyei Balassa János Kórház Szekszárd.
    Authors would like to demonstrate the beneficial effect of myo-inositol supplementation in a pregnant woman with insulin-dependent type 2 diabetes mellitus and polycystic ovary syndrome. Insulin and metformin treatment could not achieve normalization of glucose homeostasis for 3 years, and hypoglycemic episodes were frequent. Myo-inositol and folic acid supplementation added to the basic treatment resulted in improved glucose levels in 2 months. Read More

    Alterations of fatty acid profiles in gestational diabetes and influence of the diet.
    Maturitas 2017 May 27;99:98-104. Epub 2017 Jan 27.
    Endocrinology and Nephrology Unit, Centre de recherche du CHU de Québec-Université Laval, Quebec, QC, Canada. Electronic address:
    Gestational diabetes mellitus (GDM) is a pregnancy-induced complication with increased prevalence, especially in overweight women. Fatty acid (FA) composition in tissues can reflect dietary fat intake, especially essential FA intake. Moreover, it has been shown that FA profiles in blood lipid fractions are altered in diabetic patients. Read More

    Sleep Quality and Nocturnal Sleep Duration in Pregnancy and Risk of Gestational Diabetes Mellitus.
    Sleep 2017 Feb;40(2)
    Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, Singapore, Singapore.
    Study Objectives: To examine the influence of maternal sleep quality and nocturnal sleep duration on risk of gestational diabetes mellitus (GDM) in a multiethnic Asian population.

    Methods: A cohort of 686 women (376 Chinese, 186 Malay, and 124 Indian) with a singleton pregnancy attended a clinic visit at 26-28 weeks of gestation as part of the Growing Up in Singapore Towards healthy Outcomes mother-offspring cohort study. Self-reported sleep quality and sleep duration were assessed using the Pittsburgh Sleep Quality Index (PSQI). Read More

    Serum levels of nesfatin-1 are increased in gestational diabetes mellitus.
    Gynecol Endocrinol 2017 Mar 31:1-4. Epub 2017 Mar 31.
    c Key Laboratory for Major Obstetric Diseases of Guangdong Higher Education Institutes , Guangzhou , PR China.
    Objective: To analyze the concentrations of nesfatin-1 in maternal and cord serum, to evaluate the expression of nesfatin-1 in subcutaneous adipose tissue (SAT) from pregnant women with gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT).

    Methods: We studied a total of 50 GDM and 50 NGT subjects. The clinical features, serum nesfatin-1, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profiles were measured at the third trimester of pregnancy. Read More

    GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes.
    Can J Diabetes 2017 Mar 27. Epub 2017 Mar 27.
    Department of Physiology, Pomeranian Medical University, Szczecin, Poland. Electronic address:
    Objectives: Gestational diabetes mellitus (GDM) is the carbohydrate intolerance that can occur in pregnancy. Genetic polymorphisms associated with type 2 diabetes could be considered as genetic determinants of GDM. The aim of this study was to examine the association between GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 gene polymorphisms and the development of gestational diabetes. Read More

    Comparison of leukocyte IL6 expression in patients with gestational diabetes mellitus (GDM) diagnosed by the Polish Diabetes Association (PDA) 2011 and 2014 criteria.
    Endokrynol Pol 2017 Mar 29. Epub 2017 Mar 29.
    Medical University of Lodz.
    Introduction: Controversial data exist in the literature regarding relationship of IL-6 with gestational diabetes mellitus (GDM), partially resulting from different criteria for GDM classification. In the present study, we revised this linkage by investigating leukocyte IL6 expression and its associations with clinical characteristics of patients diagnosed by the Polish Diabetes Association (PDA) 2011 and 2014 criteria.

    Materials And Methods: 145 pregnant women underwent a 75 g 2-h OGTT and GDM was diagnosed according to the PDA 2011 and 2014 recommendations. Read More

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