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    Maternal-Fetal Outcomes in 34 Pregnant Women with Type 1 Diabetes in Sensor-Augmented Insulin Pump Therapy.
    Diabetes Technol Ther 2017 Jul;19(7):417-422
    1 Division of Endocrinology, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio , Bogotá, Colombia .
    Background: Pregnancy in women with type 1 diabetes (T1D) is associated with increased risk of maternal complications and neonatal morbidity and mortality. Optimizing glycemic control improves these outcomes.

    Objective: To describe the experience of using sensor-augmented insulin pump therapy (SAPT) and SAPT + low-glucose suspension (LGS) on pregnant women with T1D, including neonatal and maternal outcomes. Read More

    Insulin secretion and action in North Indian women during pregnancy.
    Diabet Med 2017 Jul 21. Epub 2017 Jul 21.
    Department of Endocrinology (Diabetes and Metabolism), Rigshospitalet, Denmark.
    Aim: The relative roles(s) of impaired insulin secretion vs. insulin resistance in the development of gestational diabetes mellitus depend upon multiple risk factors and diagnostic criteria. Here, we explored their relative contribution to gestational diabetes as defined by the WHO 1999 (GDM1999) and adapted WHO 2013 (GDM2013) criteria, excluding the 1-h glucose value, in a high-risk Indian population from Punjab. Read More

    Stroke in women - from evidence to inequalities.
    Nat Rev Neurol 2017 Jul 21. Epub 2017 Jul 21.
    Department of Neurology, Bispebjerg og Frederiksberg Hospital, Bispebjerg Bakke 23, University of Copenhagen, 2400 NV, Denmark.
    Stroke is the second largest cause of disability-adjusted life-years lost worldwide. The prevalence of stroke in women is predicted to rise rapidly, owing to the increasing average age of the global female population. Vascular risk factors differ between women and men in terms of prevalence, and evidence increasingly supports the clinical importance of sex differences in stroke. Read More

    Evidence that Children Born at Early Term (37-38-6/7 weeks) Are at Increased Risk for Diabetes and Obesity-related Disorders.
    Am J Obstet Gynecol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Background: Prematurity is known to be associated with high rates of endocrine and metabolic complications in the offspring. Early term (37 0/7-38 6/7 weeks' gestation) born offspring were also shown to exhibit long term morbidity resembling that of late preterm, in several health categories.

    Objective: We aimed to determine whether early term delivery impacts on the long-term endocrine and metabolic health of the offspring. Read More

    Poor Reliability and Poor Adherence to Self-Monitoring of Blood Glucose Are Common in Women With Gestational Diabetes Mellitus and May Be Associated With Poor Pregnancy Outcomes.
    Diabetes Care 2017 Jul 19. Epub 2017 Jul 19.
    Department of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, AP-HP, Université Paris 13, CRNH-IdF, CINFO, Bondy, France.
    Objective: To evaluate the compliance with self-monitoring of blood glucose (SMBG) and the reliability of diabetes logbooks in women with gestational diabetes mellitus (GDM), as well as the associated determinants and outcomes.

    Research Design And Methods: We prospectively selected French-speaking women with newly diagnosed GDM who had been referred to our diabetes management program and understood SMBG principles. At the next follow-up visit, we collected SMBG results from glucose meters and logbooks. Read More

    Prenatal and postnatal administration of prebiotics and probiotics.
    Semin Fetal Neonatal Med 2017 Jul 15. Epub 2017 Jul 15.
    Department of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, USA. Electronic address:
    Colonization of the neonatal gut by beneficial bacteria is important for the establishment and maintenance of the mucosal barrier, thus protecting the neonate from enteric pathogens and local and systemic inflammation. The neonatal microbiome is influenced by infant diet, environment, and the maternal microbiome. Dysbiosis in pregnancy increases the risk of pre-eclampsia, diabetes, infection, preterm labor, and later childhood atopy. Read More

    Plasma and amniotic fluid PPARγ is involved in the lipid metabolism of maternal-fetal interface cells.
    J Matern Fetal Neonatal Med 2017 Jul 19:1-9. Epub 2017 Jul 19.
    a Obstetrics and Gynecology Hospital , Fudan University , Shanghai , China.
    Objectives: The aim of this study was at detecting the expression of peroxisome proliferator-activated receptor γ (PPARγ) in patients with gestational diabetes mellitus (GDM) and to investigate whether PPARγ regulates the lipid metabolism of maternal-fetal interface cells.

    Methods: We detected the expression of PPARγ in the maternal plasma, fetal plasma and amniotic fluid of two groups of women with GDM or normal pregnancy using ELISA and western blot. Establish the cell models of the indirect coculture model and the separate culture model using BeWo cells and endometrial stromal cells (ESCs). Read More

    A Review of Systemic Corticosteroid Use in Pregnancy and the Risk of Select Pregnancy and Birth Outcomes.
    Rheum Dis Clin North Am 2017 Aug;43(3):489-502
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, Mail Code 0828, La Jolla, CA 92093-0412, USA.
    The evidence to date regarding corticosteroid exposure in pregnancy and select pregnancy and birth outcomes is limited and inconsistent. The authors provide a narrative review of published literature summarizing the findings for oral clefts, preterm birth, birth weight, preeclampsia, and gestational diabetes mellitus. Whenever possible, the results are limited to oral or systemic administration with a further focus on use in autoimmune disease. Read More

    The brown-fat-secreted adipokine neuregulin 4 is decreased in gestational diabetes mellitus.
    Diabetes Metab 2017 Jul 11. Epub 2017 Jul 11.
    Department of Endocrinology and Nephrology, University of Leipzig, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB Adiposity Diseases, 04103 Leipzig, Germany. Electronic address:
    Aims: Neuregulin 4 has recently been recognized as a novel adipokine secreted by brown adipose tissue (BAT), with beneficial effects on murine insulin resistance and hepatic steatosis. Yet, thus far, neither regulation of neuregulin 4 in gestational diabetes mellitus (GDM) nor its longitudinal changes in the peripartum period have been elucidated.

    Methods: Circulating neuregulin 4 levels were measured by ELISA in 74 women with GDM and 74 healthy, gestational-age-matched controls. Read More

    Prediction of Preeclampsia in Early Pregnancy by Estimating the Spot Urinary Albumin/Creatinine Ratio.
    J Obstet Gynaecol India 2017 Aug 19;67(4):258-262. Epub 2016 Dec 19.
    Department of Obstetrics and Gynecology, ESI PGIMSR, Basaidarapur, New Delhi, India.
    Objective: To assess whether a spot urinary albumin:creatinine ratio (ACR) measured before 20 weeks of gestation can predict subsequent development of preeclampsia.

    Methods: The ACR was determined from midstream urine sample taken between 17 and 20 weeks of gestation. Urine albumin was measured by immunoturbidimetric method using commercially available kit (Beckman Coulter) through Beckman AU 480 fully automated biochemistry analyzer. Read More

    Prevalence of gestational diabetes mellitus based on various screening strategies in western Kenya: a prospective comparison of point of care diagnostic methods.
    BMC Pregnancy Childbirth 2017 Jul 14;17(1):226. Epub 2017 Jul 14.
    Department of Diabetes, Endocrinology & Metabolism, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
    Background: Early diagnosis of gestational diabetes mellitus (GDM) is crucial to prevent short term delivery risks and long term effects such as cardiovascular and metabolic diseases in the mother and infant. Diagnosing GDM in Sub-Saharan Africa (SSA) however, remains sub-optimal due to associated logistical and cost barriers for resource-constrained populations. A cost-effective strategy to screen for GDM in such settings are therefore urgently required. Read More

    Epidemiology of gestational diabetes mellitus according to IADPSG/WHO 2013 criteria among obese pregnant women in Europe.
    Diabetologia 2017 Jul 12. Epub 2017 Jul 12.
    Galway Diabetes Research Centre, College of Medicine, Nursing and Health Sciences, National University of Ireland, University Road, Galway, H91 TK33, Ireland.
    Aims/hypothesis: Accurate prevalence estimates for gestational diabetes mellitus (GDM) among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic criteria and screening strategies in both high-risk women and the general pregnant population. Our aims were to report important risk factors for GDM development and calculate the prevalence of GDM in a cohort of women with BMI ≥29 kg/m(2) across 11 centres in Europe using the International Association of the Diabetes and Pregnancy Study Groups (IADPSG)/WHO 2013 diagnostic criteria.

    Methods: Pregnant women (n = 1023, 86. Read More

    Screening and diagnosis of gestational diabetes mellitus - relevance to low and middle income countries.
    Clin Diabetes Endocrinol 2016 1;2:13. Epub 2016 Jun 1.
    Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre WHO Collaborating Center for Non-Communicable Disease Prevention and Control, 4, Conran Smith Road, Gopalapuram, Chennai, 600 086 India.
    Gestational diabetes mellitus (GDM) is one of the most common metabolic complications of pregnancy. Ever since the first systematic evaluation of the oral glucose tolerance test by O'Sullivan and colleagues was carried out in 1964, there has been controversy with respect to the optimal screening and diagnostic criteria to detect GDM. The recently proposed International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for GDM has found fairly widespread acceptance, but it is still debated by several societies. Read More

    Healthy eating and active living after gestational diabetes mellitus (HEALD-GDM): Rationale, design, and proposed evaluation of a randomized controlled trial.
    Contemp Clin Trials 2017 Jul 9;61:23-28. Epub 2017 Jul 9.
    School of Public Health, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
    Background: Gestational diabetes mellitus (GDM) is a common complication in pregnancy and a significant risk factor for type 2 diabetes (T2D). Most women who have had GDM are not engaging in health behaviours known to reduce their risk for developing future T2D. The objective of this study is to evaluate the effectiveness of a lifestyle modification program targeting healthy eating and active living behaviours after a GDM pregnancy. Read More

    Glycated albumin: a potential biomarker in diabetes.
    Arch Endocrinol Metab 2017 May-Jun;61(3):296-304
    Programa de Pós-graduação em Ciências Médicas - Endocrinologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
    Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron deficiency anemia, hemoglobinopathies, pregnancy, and uremia. Read More

    History of Gestational Diabetes Mellitus in Relation to Cardiovascular Disease and Cardiovascular Risk Factors in US Women.
    Front Endocrinol (Lausanne) 2017 26;8:144. Epub 2017 Jun 26.
    Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States.
    Background: Findings from previous studies examining the association between gestational diabetes mellitus (GDM) and subsequent risk of cardiovascular disease (CVD) have been inconsistent and inconclusive. We aimed to examine the associations of a previous history of GDM with risk of CVD and status of cardiovascular risk factors in a nationwide population-based study in the United States.

    Methods: This study included 8,127 parous women aged 20 years or older in the 2007-2014 cycles of the National Health and Nutrition Examination Survey in the United States. Read More

    [Sleep apnea in pregnancy].
    Rev Med Suisse 2016 Oct;12(536):1816-1820
    Unité de recherche en médecine materno-fœtale et obstétrique, Maternité, Département Femme-Mère-Enfant, CHUV, 1011 Lausanne.
    Snoring, chronic rhinitis and fragmentation of sleep are common symptoms in pregnancy, especially in the third trimester. The prevalence of obstructive sleep apnea is also increased in pregnant women and can be associated with pregnancy induced hypertension, preeclampsia and diabetes mellitus. The fetus is as well exposed to a higher risk of prematurity and intra-uterine growth restriction. Read More

    Basal-bolus insulin therapy reduces maternal triglycerides in gestational diabetes without modifying cholesteryl ester transfer protein activity.
    J Obstet Gynaecol Res 2017 Jul 10. Epub 2017 Jul 10.
    Departments of Respiratory Diseases, College of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Aim: Macrosomia in the offspring of overweight/obese mothers with glucose-controlled gestational diabetes mellitus (GDM) is due to excessive rise of maternal triglycerides (TG). We aimed to ascertain whether basal-bolus insulin therapy (BBIT), or other components of the treatment, could reduce TG in GDM.

    Methods: We studied the records of 131 singleton pregnancies with GDM, using stepwise multiple linear regression, Mann-Whitney, χ(2) , and Jonckheere-Terpstra tests. Read More

    Women with Subclinical Hypothyroidism Are at Low Risk of Poor Pregnancy Outcome in Japan.
    Tohoku J Exp Med 2017 ;242(3):167-172
    Department of Obstetrics and Gynecology, School of Medicine, Kyorin University.
    Maternal subclinical hypothyroidism may be associated with adverse pregnancy outcomes, although not consistently across regions. Here, we sought to determine the effect of elevated thyroid-stimulating hormone (TSH) on pregnancy outcomes in Japanese women without known medical complications. TSH was determined by dried blood spots at 8-20 weeks of gestation, and 3. Read More

    Resistin role in development of gestational diabetes mellitus.
    Biomark Med 2017 Jul 7;11(7):579-586. Epub 2017 Jul 7.
    Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Diabetes is estimated to be one of the major causes of deaths in most countries due to its high prevalence rate, which was 8.8% in 2015. Hyperglycemia detected during pregnancy is known as gestational diabetes mellitus and it increases the potential risk of development of Type 2 diabetes in mothers with its varying prevalence rate of 1-14% in different populations. Read More

    Maternal protein intake in pregnancy and offspring metabolic health at age 9-16 y: results from a Danish cohort of gestational diabetes mellitus pregnancies and controls.
    Am J Clin Nutr 2017 Jul 5. Epub 2017 Jul 5.
    Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
    Background: Recent years have seen strong tendencies toward high-protein diets. However, the implications of higher protein intake, especially during developmentally sensitive periods, are poorly understood. Conversely, evidence on the long-term developmental consequences of low protein intake in free-living populations remains limited. Read More

    Use of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) and PROK1/PAPP-A ratio to predict adverse pregnancy outcomes in the first trimester: a prospective study.
    J Matern Fetal Neonatal Med 2017 Jul 16:1-8. Epub 2017 Jul 16.
    a Trakya University Faculty of Medicine, Obstetrics and Gynecology , Edirne , Turkey.
    Introduction: To compare the predictive effectiveness levels of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) and the PROK1/PAPP-A ratio in the first trimester for preeclampsia (PE), foetal growth restriction (FGR), gestational diabetes mellitus (GDM) and spontaneous preterm birth (SPB).

    Materials And Methods: A total of randomly selected 162 pregnant women were included. Peripheral blood samples were obtained between 11(0/7) and 13(6/7) gestational weeks (GWs). Read More

    Effect of Fetal Sex on Maternal and Obstetric Outcomes.
    Front Pediatr 2017 19;5:144. Epub 2017 Jun 19.
    Department Obstetrics and Gynecology, Division Maternal-Fetal Medicine, UConn Health John Dempsey Hospital, Farmington, CT, United States.
    Fetal sex plays an important role in modifying the course and complications related to pregnancy and may also have an impact on maternal health and well-being both during and after pregnancy. The goal of this article is to review and summarize the findings from published research on physiologic and pathologic changes that may be affected by fetal sex and the effect of these changes on the maternal and obstetrical outcomes. This will help create awareness that fetal sex is not just a random chance event but an interactive process between the mother, the placenta, and the fetus. Read More

    Diabetes during Pregnancy: Influence of Body Mass Index on Composite Morbidity.
    AJP Rep 2017 Apr 30;7(2):e128-e133. Epub 2017 Jun 30.
    Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School-The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.
    Objective  This study aims to compare composite maternal and neonatal morbidities (MM, NM) among pregnant women with diabetes mellitus whose body mass index (BMI) at delivery was < 30 (group 1), 30.0 to 39.9 (group 2), and ≥ 40 kg/m (2) (group 3). Read More

    The effect of guided self-determination on self-management in persons with type 1 diabetes mellitus and HbA1c ≥64 mmol/mol: a group-based randomised controlled trial.
    BMJ Open 2017 Jul 3;7(6):e013295. Epub 2017 Jul 3.
    Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
    Objectives: To determine whether the impact of guided self-determination (GSD) applied in group training (GSD-GT) in people with chronically elevated HbA1c and type 1 diabetes mellitus (DM) was superior to 'care as usual' in improving HbA1c and psychological functioning.

    Setting: An outpatient clinic at a university hospital in Western Norway.

    Participants: A total of 178 adults (all Caucasian) aged 18-55 (mean age 36. Read More

    High altitude and pre-eclampsia: Adaptation or protection.
    Med Hypotheses 2017 Jul 10;104:128-132. Epub 2017 May 10.
    Field & Research Stations, Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan.
    Adaptive genes of high altitude can also be protective in diseases like preeclampsia, hypertension, and diabetes mellitus, Alzheimer, Parkinson Disease and Cancer, which may result from deregulation of hypoxia pathway. The example of pre-eclampsia and normal pregnancy were studied to see if the hypoxia-induced disorders can be dragged towards adaptation. Here, we analyse the genetic variants that are known to be associated with adaptation to high altitude hypoxia. Read More

    Gestational diabetes mellitus was related to ambient air pollutant nitric oxide during early gestation.
    Environ Res 2017 Jun 30;158:318-323. Epub 2017 Jun 30.
    Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, Taipei, Taiwan; Department of Environmental and Occupational Medicine, College of Medicine, National Taiwan University (NTU) and NTU Hospital, Taipei, Taiwan; National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Electronic address:
    Background: Ambient air pollution has been linked to the risk of gestational diabetes mellitus (GDM). However, evidence of this association is limited, and no study has examined the effects of nitric oxide (NO).

    Objective: This study investigated the association between air pollution exposure during gestation and GDM. Read More

    The Prevalence of Gestational Diabetes.
    Dtsch Arztebl Int 2017 07;114(24):412-418
    National Association of Statutory Health Insurance Physicians (NASHIP), Department for Cross-Sectoral Quality Improvement, Berlin, Germany; National Association of Statutory Health Insurance Physicians (NASHIP), Section Innovation, Strategic Analysis and IT Consulting, Berlin, Germany.
    Background: Gestational diabetes mellitus (GDM) is defined as a glucose tolerance disorder that arises during pregnancy. Estimates of its prevalence vary widely because of varying threshold values. Screening of all pregnant women with a two-step test has been available in Germany since 2012. Read More

    Targeting Adrenomedullin to Improve Lipid Homeostasis in Diabetic Pregnancies.
    J Clin Endocrinol Metab 2017 Jun 28. Epub 2017 Jun 28.
    Department of Obstetrics and Gynecology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX.
    Context: Gestational diabetes mellitus (GDM) is associated with disturbances in maternal lipid metabolism. Hypertriacylglycerolemia in GDM is associated with an increased risk of large for gestational age neonates, but the pathogenesis of disrupted lipid homeostasis remains unclear.

    Objectives: To determine the role of adrenomedullin (AM), a multifunctional peptide, in lipid metabolism in GDM. Read More

    Association between hypertensive disorders of pregnancy and the risk of postpartum hypertension: a cohort study in women with gestational diabetes.
    J Hum Hypertens 2017 Jun 29. Epub 2017 Jun 29.
    Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
    Previous studies in general people indicated that hypertensive disorders of pregnancy (HDP) increased the risk of subsequent hypertension after delivery. Some studies found that women with gestational diabetes mellitus (GDM) had an increased risk of HDP. However, very few studies have assessed the association between HDP and the risk of postpartum hypertension among GDM women. Read More

    Gestational Diabetes Mellitus Is Associated with Altered Neutrophil Activity.
    Front Immunol 2017 14;8:702. Epub 2017 Jun 14.
    Department of Biomedicine, University of Basel, University Hospital of Basel, Basel, Switzerland.
    Gestational diabetes mellitus (GDM) is a unique form of glucose intolerance, in that it is transient and solely occurs in pregnancy. Pregnancies with GDM are at high risk of developing preeclampsia (PE), a leading cause of fetal and maternal morbidity or mortality. Since PE is associated with excessive activation of circulatory neutrophils and occurrence of neutrophil extracellular traps (NETs) in affected placentae, we examined these features in cases with GDM, as this could be a feature linking the two conditions. Read More

    The Immunosignature of Mother/Fetus Couples in Gestational Diabetes Mellitus: Role of HLA-G 14 bp ins/del and PAPP-A A/C Polymorphisms in the Uterine Inflammatory Milieu.
    Dis Markers 2017 1;2017:4254750. Epub 2017 Jun 1.
    Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy.
    We enrolled 151 healthy mother/newborn couples and 26 with gestational diabetes mellitus (GDM). HLA-G and PAPP-A plasma levels were measured by ELISA at first and second trimesters, at delivery, and in cord blood. HLA-G 14 bp ins/del and PAPP-A A/C polymorphisms were genotyped. Read More

    Determinants of gestational diabetes mellitus: a case-control study.
    J Matern Fetal Neonatal Med 2017 Jul 9:1-6. Epub 2017 Jul 9.
    a Department of Epidemiology & Biostatistics , University of Bahir Dar , Bahir Dar , Ethiopia.
    Background: Gestational diabetes mellitus (GDM) is glucose intolerance first recognized during pregnancy. The objective of this study was to identify the determinant factors of GDM.

    Methods: An unmatched case-control study was conducted. Read More

    Epigenetic adaptation of the placental serotonin transporter gene (SLC6A4) to gestational diabetes mellitus.
    PLoS One 2017 26;12(6):e0179934. Epub 2017 Jun 26.
    Division of Molecular Biology, Rudjer Boskovic Institute, Zagreb, Croatia.
    We tested the hypothesis that gestational diabetes mellitus (GDM) alters the DNA methylation pattern of the fetal serotonin transporter gene (SLC6A4), and examined the functional relevance of DNA methylation for regulation of the SLC6A4 expression in the human placenta. The study included 50 mother-infant pairs. Eighteen mothers were diagnosed with GDM and 32 had normal glucose tolerance (NGT). Read More

    Early Life Risk Factors for Incident Atrial Fibrillation in the Helsinki Birth Cohort Study.
    J Am Heart Assoc 2017 Jun 25;6(6). Epub 2017 Jun 25.
    Folkhälsan Research Center, Helsinki, Finland.
    Background: Early life risk factors are associated with cardiometabolic disease, but have not been fully studied in atrial fibrillation (AF). There are discordant results from existing studies of birth weight and AF, and the impact of maternal body size, gestational age, placental size, and birth length is unknown.

    Methods And Results: The Helsinki Birth Cohort Study includes 13 345 people born as singletons in Helsinki in the years 1934-1944. Read More

    Pregnancy outcome in women with cystic fibrosis-related diabetes.
    Acta Obstet Gynecol Scand 2017 Jun 24. Epub 2017 Jun 24.
    Cystic Fibrosis Adult Referral Care Center, Department of Internal Medicine, Civil Hospices of Lyon, EA-HESPER7425, University of Lyon, Lyon, France.
    Introduction: With increasing life expectancy, more women with cystic fibrosis and diabetes mellitus become pregnant. We investigated how pre-gestational diabetes (cystic fibrosis-related diabetes) influenced pregnancy outcome and the clinical status of these women.

    Material And Methods: We analyzed all pregnancies reported to the French cystic fibrosis registry between 2001 and 2012, and compared forced expiratory volume (FEV1 ) and body mass index before and after pregnancy in women with and without pre-gestational diabetes having a first delivery. Read More

    Metabolomics of Diabetes in Pregnancy.
    Curr Diab Rep 2017 Aug;17(8):57
    Department of Nutritional Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, USA.
    Purpose Of Review: The purpose of this review is to describe ways in which metabolomics may enhance understanding of gestational diabetes mellitus (GDM) etiology and refine current diagnostic criteria.

    Recent Findings: Current clinical recommendations suggest screening for GDM between 24 and 28 of gestational weeks using an oral glucose tolerance test. Despite this consensus, there are discrepancies regarding the exact criteria for GDM diagnosis. Read More

    Impact of birth weight on adult-onset diabetes mellitus in relation to current body mass index: The Japan Nurses' Health Study.
    J Epidemiol 2017 Jun 20. Epub 2017 Jun 20.
    Department of Basic Allied Medicine, School of Health Science, Gunma University, Gunma, Japan.
    Background: Although birth weight is considered as a fetal determinant of the development of adult-onset diabetes mellitus (DM), its public health importance relative to adult body mass index (BMI) remains unclear. We aimed to examine the association between adult-onset DM and birth weight in relation to adult BMI.

    Methods: We conducted a self-administered questionnaire as a baseline survey of the Japanese Nurses' Health Study cohort between 2001 and 2007. Read More

    Gestational diabetes mellitus and risk of type 2 diabetes 10 years after the index pregnancy in Sri Lankan women-A community based retrospective cohort study.
    PLoS One 2017 23;12(6):e0179647. Epub 2017 Jun 23.
    Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
    Background: Women with a history of gestational diabetes mellitus (GDM) have an increased risk of type 2 diabetes mellitus (T2DM) later in life compared to women with no GDM. This study was aimed to determine the risk of developing T2DM 10 years after GDM in Sri Lankan women.

    Methods: A retrospective cohort study was conducted in the Colombo district, Sri Lanka. Read More

    Practice Bulletin No. 180: Gestational Diabetes Mellitus.
    • Authors:
    Obstet Gynecol 2017 07;130(1):e17-e37
    Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. However, debate continues to surround the diagnosis and treatment of GDM despite several recent large-scale studies addressing these issues. The purposes of this document are the following: 1) provide a brief overview of the understanding of GDM, 2) review management guidelines that have been validated by appropriately conducted clinical research, and 3) identify gaps in current knowledge toward which future research can be directed. Read More

    Practice Bulletin No. 180 Summary: Gestational Diabetes Mellitus.
    • Authors:
    Obstet Gynecol 2017 Jul;130(1):244-246
    Gestational Diabetes Mellitus: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. However, debate continues to surround the diagnosis and treatment of GDM despite several recent large-scale studies addressing these issues. The purposes of this document are the following: 1) provide a brief overview of the understanding of GDM, 2) review management guidelines that have been validated by appropriately conducted clinical research, and 3) identify gaps in current knowledge toward which future research can be directed. Read More

    Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes.
    Metabolism 2017 Jul 4;72:27-36. Epub 2017 Jan 4.
    Institute of Neuroscience and Physiology, University of Gothenburg.
    Context: Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM.

    Objective: To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. Read More

    Maternal intake of fried foods and risk of gestational diabetes mellitus.
    Ann Epidemiol 2017 Jun 12;27(6):384-390.e1. Epub 2017 May 12.
    Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.
    Purpose: We examined the relationship of maternal periconceptional (i.e., before conception and early pregnancy) intake of fried foods with gestational diabetes mellitus (GDM) risk. Read More

    Exercise for pregnant women with gestational diabetes for improving maternal and fetal outcomes.
    Cochrane Database Syst Rev 2017 06 22;6:CD012202. Epub 2017 Jun 22.
    Liggins Institute, The University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.
    Background: Gestational diabetes mellitus (GDM) is associated with both short- and long-term complications for the mother and her baby. Exercise interventions may be useful in helping with glycaemic control and improve maternal and infant outcomes.The original review on Exercise for diabetic pregnant women has been split into two new review titles reflecting the role of exercise for pregnant women with gestational diabetes and for pregnant women with pre-existing diabetes. Read More

    Evaluation of 75 g glucose load in non-fasting state [Diabetes in Pregnancy Study group of India (DIPSI) criteria] as a diagnostic test for gestational diabetes mellitus.
    Indian J Med Res 2017 Feb;145(2):209-214
    Department of Obstetrics & Gynaecology, Lok Nayak Hospital, New Delhi, India.
    Background & Objectives: There is no consensus regarding optimal standard for diagnosis of gestational diabetes mellitus (GDM). In this study, use of 75 g glucose load in non-fasting state [Diabetes in Pregnancy Study Group of India (DIPSI) criteria] as a diagnostic test for GDM in pregnant women was compared with different oral glucose tolerance tests (OGTTs).

    Methods: This prospective study included 936 pregnant women, who underwent plasma glucose evaluation two hours after the challenge of 75 g glucose load irrespective of the timing of last meal (DIPSI criteria for GDM). Read More

    Laboratory diagnosis of overt type 2 diabetes in the first trimester of pregnancy.
    J Am Assoc Nurse Pract 2017 Jun 22. Epub 2017 Jun 22.
    School of Nursing, University of Northern Colorado, Greeley, Colorado.
    Objective: The objective of this study was to compare the use of hemoglobin A1C to oral glucose tolerance testing to diagnose overt type 2 diabetes in the first trimester of pregnancy. The study used a nonexperimental descriptive design to compare the use of the hemoglobin A1C test results to oral glucose tolerance test results.

    Methods: The study used a sample of 45 women at high risk for type 2 diabetes in the first trimester of pregnancy. Read More

    Socio-economic status and risk of gestational diabetes mellitus among Chinese women.
    Diabet Med 2017 Jun 21. Epub 2017 Jun 21.
    Department of Maternal and Child Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Aims: The relationship between socio-economic status and gestational diabetes mellitus has received little attention. The purpose of this study was to investigate the association between socio-economic status and risk of gestational diabetes.

    Methods: Data were obtained from the ongoing Healthy Baby Cohort study in Hubei Province, China, in 2012-2014. Read More

    A randomized lifestyle intervention preventing gestational diabetes: effects on self-rated health from pregnancy to postpartum.
    J Psychosom Obstet Gynaecol 2017 Feb 9:1-6. Epub 2017 Feb 9.
    d Department of Obstetrics and Gynecology , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
    Introduction: The purpose was to examine the effects of a randomized lifestyle intervention on self-rated health from pregnancy to postpartum in participants at high risk for gestational diabetes mellitus.

    Methods: We included 266 women with a history of gestational diabetes and/or prepregnancy BMI ≥30 kg/m(2). The intervention group (n = 144) received individualized counseling on diet, physical activity, and weight management from trained nurses at six timepoints between the first trimester of pregnancy and 12 months postpartum, and met three times with a dietitian. Read More

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