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    Impact of adopting the 2013 World Health Organization criteria for diagnosis of gestational diabetes in a multi-ethnic Asian cohort: a prospective study.
    BMC Pregnancy Childbirth 2018 Mar 21;18(1):69. Epub 2018 Mar 21.
    Department of Obstetrics & Gynaecology, National University Hospital, Singapore, 119074, Singapore.
    Background: We assessed the impact of adopting the 2013 World Health Organization (WHO) diagnostic criteria on the rates of gestational diabetes (GDM), pregnancy outcomes and identification of women at future risk of type 2 diabetes.

    Methods: During a period when the 1999 WHO GDM criteria were in effect, pregnant women were universally screened using a one-step 75 g 2-h oral glucose tolerance test at 26-28 weeks' gestation. Women were retrospectively reclassified according to the 2013 criteria, but without the 1-h glycaemia measurement. Read More

    Endocr Pract 2018 Mar 21. Epub 2018 Mar 21.
    Objective: Our pilot study examined the effectiveness of sitagliptin-metformin (SITA-MET), metformin (MET), and placebo (P) therapy on fasting and post-glucose challenge glucose levels in postpartum women with prior gestational diabetes mellitus (GDM) and impaired glucose regulation.

    Methods: Prediabetic women (N = 36, age 18 to 42 years) with recent GDM were randomized to P (one pill twice a day), MET (1,000 mg twice a day), or SITA-MET (50 mg SITA, 1,000 mg MET twice a day) for 16 weeks in a single-blind fashion. An individualized diet and exercise plan were provided to all participants. Read More

    Transient epigenomic changes during pregnancy and early postpartum in women with and without type 2 diabetes.
    Epigenomics 2018 Mar 21. Epub 2018 Mar 21.
    Centre for Cellular & Molecular Biology, School of Life & Environmental Sciences, Deakin University, Burwood, Victoria 3125, Australia.
    Aim: To investigate epigenomic changes in pregnancy and early postpartum in women with and without type 2 diabetes.

    Methods: Dimethylation of histones H3K4, H3K9, H3K27, H3K36 and H3K79 was measured in white blood cells of women at 30 weeks pregnancy, at 8-10 and 20 weeks postpartum and in never-pregnant women.

    Results: Dimethylation levels of all five histones were different between women in pregnancy and early postpartum compared with never-pregnant women and were different between women with and without type 2 diabetes. Read More

    Relationship between advanced glycation end products and gestational diabetes mellitus.
    J Matern Fetal Neonatal Med 2018 Mar 21:1-7. Epub 2018 Mar 21.
    b Peking University First Hospital , Obstetrics and Gynecology , Beijing , China.
    Objective: To investigate the levels of and dynamic changes of advanced glycation end products (AGEs) in maternal plasma during pregnancy and explore the association between these levels and gestational diabetes mellitus (GDM).

    Methods: This study recruited 90 GDM women and 90 healthy pregnant controls. The women received prenatal care and were hospitalized for delivery in Peking University First Hospital in China between October 2015 and April 2016. Read More

    Comparison of umbilical artery Doppler and non-stress test in assessment of fetal well-being in gestational diabetes mellitus: A prospective cohort study.
    Electron Physician 2017 Dec 25;9(12):6087-6093. Epub 2017 Dec 25.
    Ph.D. of Reproductive Health, Assistant professor, Department of Midwifery, School of Nursing & Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran.
    Background: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy and is related to poor perinatal outcomes. Reduction of neonatal complications of GDM is feasible by assessment of fetal well-being. Both fetal Doppler and NST are used for the screening of high-risk pregnancies. Read More

    Gestational Diabetes Mellitus: Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds.
    Diabetes Care 2018 Mar 20. Epub 2018 Mar 20.
    Department of Endocrinology, Odense University Hospital, Odense, Denmark.
    Objective: To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort.

    Research Design And Methods: This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria. FVPG measured at 28 weeks' gestation was related to pregnancy outcomes. Read More

    Comparing the Efficacy of a Mobile Phone-Based Blood Glucose Management System With Standard Clinic Care in Women With Gestational Diabetes: Randomized Controlled Trial.
    JMIR Mhealth Uhealth 2018 Mar 20;6(3):e71. Epub 2018 Mar 20.
    Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom.
    Background: Treatment of hyperglycemia in women with gestational diabetes mellitus (GDM) is associated with improved maternal and neonatal outcomes and requires intensive clinical input. This is currently achieved by hospital clinic attendance every 2 to 4 weeks with limited opportunity for intervention between these visits.

    Objective: We conducted a randomized controlled trial to determine whether the use of a mobile phone-based real-time blood glucose management system to manage women with GDM remotely was as effective in controlling blood glucose as standard care through clinic attendance. Read More

    Non-dioxin-like polychlorinated biphenyls in early pregnancy and risk of gestational diabetes mellitus.
    Environ Int 2018 Mar 17;115:127-132. Epub 2018 Mar 17.
    The Key Laboratory of Food Safety Risk Assessment, Ministry of Health (CFSA) and China National Center for Food Safety Risk Assessment, Beijing, China.
    Several studies support a plausible association of human exposure to polychlorinated biphenyls (PCBs) with type 2 diabetes mellitus. However, little is known about the potential link between circulating PCBs levels in early pregnancy and development of gestational diabetes mellitus (GDM). Here, we conducted a prospective study with a nested case-control design to determine the association of PCB exposure in early pregnancy with GDM risk. Read More

    Preliminary evaluation of foetal liver volume by three-dimensional ultrasound in women with gestational diabetes mellitus.
    J Obstet Gynaecol 2018 Mar 19:1-5. Epub 2018 Mar 19.
    a Department of Obstetrics and Gynecology , Health Sciences University, Süleymaniye Women and Children's Health Training and Research Hospital , İstanbul , Turkey.
    The aim of the study was to assess the standard foetal biometric measurements and foetal liver volume (FLV) in pregnancies complicated by gestational diabetes mellitus (GDM) at the time of GDM screening and to compare the results with foetuses in normal pregnancies. Ninety-seven pregnant women with normal singleton uncomplicated pregnancies between 24 and 28 weeks of gestation were allocated into GDM (+) (n: 33) and GDM (-) (n: 64) groups based on their 75 g oral glucose tolerance test results. Foetal biometric measurements and FLV measurements of the groups were compared. Read More

    History of spontaneous miscarriage and the risk of diabetes mellitus among middle-aged and older Chinese women.
    Acta Diabetol 2018 Mar 15. Epub 2018 Mar 15.
    Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, Hubei, China.
    Aims: Epidemiological studies of the long-term maternal health outcomes of spontaneous miscarriages have been sparse and inconsistent. The objective of our study is to examine the association between spontaneous miscarriages and diabetes among middle-aged and older Chinese women.

    Methods: A total of 19,539 women from the Dongfeng-Tongji cohort study who completed a questionnaire and had medical examinations performed on were included in the analysis. Read More

    Continuous subcutaneous insulin infusion versus multiple daily injections in pregnant women with type 1 diabetes mellitus - a systematic review and meta-analysis of randomised controlled trials and observational studies.
    Eur J Endocrinol 2018 Mar 15. Epub 2018 Mar 15.
    M Malecki, Department of Metabolic Disease, Jagiellonian University, Medical College, Krakow, Poland.
    Background: Randomised controlled trials (RCTs) have shown an advantage of continuous subcutaneous insulin infusion (CSII) over multiple daily injections (MDI) in the general type 1 diabetes mellitus (T1DM) population. RCT data on T1DM management in pregnancy remain limited.

    Objective: We performed a systematic review of both RCTs and non-RCTs evaluating CSII versus MDI in T1DM-complicated pregnancy. Read More

    Gestational Diabetes Mellitus: Using the Fasting Plasma Glucose Level to Simplify the International Association of Diabetes and Pregnancy Study Groups Diagnostic Algorithm in an Adult South Asian Population.
    Can J Diabetes 2017 Dec 15. Epub 2017 Dec 15.
    Department of Obstetrics and Gynecology, St. Stephen's Hospital, Delhi, India.
    Objectives: To evaluate the value of the fasting plasma glucose (FPG) level for simplifying the International Association of Diabetes and Pregnancy Study Groups (IADPSG) diagnostic algorithm of gestational diabetes mellitus (GDM) in a South Asian population.

    Methods: In 6,520 pregnant women undergoing universal screening with the 75 g oral glucose tolerance test (OGTT), the area under receiver operating characteristic curve was used to determine the overall FPG performance to detect GDM (IADPSG criteria). Specifically, 2 different FPG thresholds of the OGTT were used to rule in and rule out GDM so as to decrease the need for the cumbersome OGTT. Read More

    Intra-partum management of women with diabetes.
    J Pak Med Assoc 2018 Mar;68(3):490-493
    Endocrine and Diabetes Unit, Christian Medical College and Hospital, Ludhiana, Punjab, India.
    Management of hyperglycaemia is crucial during labour to improve outcomes both in the newborn and in the mother. This is particularly crucial in mothers with pregestational type 1 diabetes and in all mothers requiring insulin treatment during pregnancy. The use of antenatal steroids in mothers at risk of preterm delivery complicates management of hyperglycaemia in the immediate antepartum period and requires appropriate dosing adjustments of insulin therapy. Read More

    Postpartum urinary tract infection by mode of delivery: a Danish nationwide cohort study.
    BMJ Open 2018 03 14;8(3):e018479. Epub 2018 Mar 14.
    Department of Gynecology and Obstetrics, Nordsjaellands Hospital, Hilleroed, Denmark.
    Objectives: To examine the association between postpartum urinary tract infection and intended mode of delivery as well as actual mode of delivery.

    Design: Retrospective cohort study.

    Setting And Participants: All live births in Denmark between 2004 and 2010 (n=450 856). Read More

    Cost-effectiveness of healthy eating and/or physical activity promotion in pregnant women at increased risk of gestational diabetes mellitus: economic evaluation alongside the DALI study, a European multicenter randomized controlled trial.
    Int J Behav Nutr Phys Act 2018 Mar 14;15(1):23. Epub 2018 Mar 14.
    Department of Health Sciences and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
    Background: Gestational diabetes mellitus (GDM) is associated with perinatal health risks to both mother and offspring, and represents a large economic burden. The DALI study is a multicenter randomized controlled trial, undertaken to add to the knowledge base on the effectiveness of interventions for pregnant women at increased risk for GDM. The purpose of this study was to evaluate the cost-effectiveness of the healthy eating and/or physical activity promotion intervention compared to usual care among pregnant women at increased risk of GDM from a societal perspective. Read More

    Higher levels of thyrotropin in pregnancy and adverse pregnancy outcomes.
    J Matern Fetal Neonatal Med 2018 Mar 14:1-131. Epub 2018 Mar 14.
    a University Hospital in Mostar , Mostar , Bosnia and Herzegovina.
    Objective: To determine the frequency of subclinical hypothyroidism in women with pathological pregnancies and the association between elevated thyroid-stimulating hormone (TSH) and pregnancy outcome.

    Subjects And Methods: A cross-sectional prospective study investigated value of TSH and free thyroxine (FT4) in: 1. pregnant women with hypertension (HTA) (N = 62) or preeclampsia (PE) (N = 50), 2. Read More

    Pregnancy outcomes in women with polycystic ovary syndrome in two Latin American populations.
    J Obstet Gynaecol 2018 Mar 14:1-6. Epub 2018 Mar 14.
    c Endocrinology and Metabolism Laboratory, School of Medicine , San Juan de Dios Hospital, University of Chile , Santiago , Chile.
    Pregnancy complications and obstetric outcomes were compared in 80 Chilean (PPCOS) and 70 Argentinian (PPCOS) pregnant women. Reference groups of Chilean and Argentinian normal pregnant women from the same antenatal care units were also compared. PPCOSshowed a higher prevalence of gestational diabetes mellitus (GDM) (OR, 2. Read More

    Maternal and Perinatal Outcome in Gestational Diabetes Mellitus in a Tertiary Care Hospital in Delhi.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):116-120
    Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
    Background: Gestational diabetes mellitus (GDM) is defined as a carbohydrate intolerance first diagnosed in pregnancy and may be associated with adverse maternal and perinatal outcome.

    Aim: The aim of the study was to determine the maternal and perinatal outcome in GDM during pregnancy.

    Materials And Methods: It is a retrospective analysis of women diagnosed with GDM who got antenatal care and delivered in our hospital in previous 5 years. Read More

    Evaluation of Oxidative Stress and Proinflammatory Cytokines in Gestational Diabetes Mellitus and Their Correlation with Pregnancy Outcome.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):79-84
    Department of Obstetrics and Gynecology, JSS Medical College, JSS University, Mysuru, Karnataka, India.
    Background: Prevalence of Gestational Diabetes Mellitus in India is increasing. In addition to performing physiological role in fetoplacental unit during pregnancy, cytokines also play pathophysiological role if expressed in abnormal amounts or sites.

    Objective: To estimate Proinflammatory Cytokines TNF-α, IL-6, IL-8 and anti-oxidants Glutathione Peroxidase (GTX), Superoxide dismutase (SOD), uric acid and Bilirubin levels in GDM and correlate with pregnancy outcome. Read More

    Do Postpartum Levels of Apolipoproteins Prospectively Predict the Development of Type 2 Diabetes in Women with Previous Gestational Diabetes Mellitus?
    Exp Clin Endocrinol Diabetes 2018 Mar 12. Epub 2018 Mar 12.
    Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia.
    Aims: The risk of developing type 2 diabetes is greater in women with previous gestational diabetes mellitus (GDM). Apolipoprotein (Apo) species have been associated with the development of type 2 diabetes in the general population. The aim of this study was to determine if circulating levels of Apo species can predict development of type 2 diabetes in women with previous GDM. Read More

    Polysaccharide IV from. Improves Lipid Profiles of Gestational Diabetes Mellitus of Pregnancy by Upregulating ABCA1 and Downregulating Sterol Regulatory Element-Binding Transcription 1miR-33.
    Front Endocrinol (Lausanne) 2018 23;9:49. Epub 2018 Feb 23.
    Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun, China.
    . (LBL) has beneficial effects on gestational diabetes mellitus (GDM) but the related mechanism remains unclear. Polysaccharides of LBL (LBLP) are the main bioactive components of LBL. Read More

    Hyperglycemia in pregnancy among South Asian women: a single tertiary care center experience from Colombo, Sri Lanka.
    Diabetes Res Clin Pract 2018 Mar 8. Epub 2018 Mar 8.
    Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Colombo, Sri Lanka.
    Aim: To study case mix, risk factors, adverse outcomes and associations of hyperglycemia in pregnancy in a cohort of Sri Lankans.

    Methods: Prospective observational study, from April 2011-October 2015 at a tertiary care referral center, Colombo, Sri Lanka. Data from first trimester to delivery of HIP was analyzed. Read More

    The prevalence of gestational diabetes mellitus amongst black South African women is a public health concern.
    Diabetes Res Clin Pract 2018 Mar 8. Epub 2018 Mar 8.
    MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Postal address: Private Bag 3, Wits, 2050, South Africa. Electronic address:
    Aims: This study aimed to determine the prevalence of GDM amongst black South African women, describe GDM-associated risk factors and clinical management, and evaluate the efficacy of the fasting plasma glucose reading in diagnosing GDM.

    Methods: A cross-sectional screening study was performed. Pregnant women were recruited from the Chris Hani Baragwanath Academic Hospital in Johannesburg. Read More

    [Odontogenic foci and systemic diseases. A review].
    Orv Hetil 2018 Mar;159(11):415-422
    Konzerváló és Esztétikai Fogászati Tanszék, Szegedi Tudományegyetem, Fogorvostudományi Kar Szeged.
    The aim of the present review is to provide an up-to-date picture of what we know about the connection between odontogenic foci and non-oral diseases. After a brief historical summary, we give an overview on how the odontogenic focus causes disease in distant areas of the body in general, and then we start the discussion of the particular conditions, such as cardiovascular diseases, pneumonia, diabetes mellitus, metabolic syndrome, rheumatoid arthritis and adverse pregnancy outcomes. The review is centered around the two main odontogenic foci: periodontitis and periapical periodontitis, the latter being a widely recognized but rarely discussed oral focus. Read More

    Comparing the risk of adverse pregnancy outcomes of Chinese patients with polycystic ovary syndrome with and without antiandrogenic pretreatment.
    Fertil Steril 2018 Mar 7. Epub 2018 Mar 7.
    Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China; Research Centre for Women's Health and University Women's Hospital of Tuebingen, University of Tuebingen, Tuebingen, Germany.
    Objective: To evaluate the prevalence of adverse pregnancy outcomes in healthy Chinese women and to investigate whether these outcomes could be decreased in patients with polycystic ovary syndrome (PCOS) by ethinylestradiol/cyproterone acetate (EE/CPA) pretreatment.

    Design: Retrospective study.

    Setting: Medical university. Read More

    The effects of metformin on maternal haemodynamics in gestational diabetes mellitus: A pilot study.
    Diabetes Res Clin Pract 2018 Mar 7. Epub 2018 Mar 7.
    University of Leicester. Electronic address:
    Background: Gestational diabetes mellitus (GDM) is a major clinical challenge and is likely to remain so as the incidence of GDM continues to increase AIM: To assess longitudinal changes in maternal haemodynamics amongst women diagnosed with GDM requiring either metformin or dietary intervention in comparison to low-risk healthy controls.

    Methodology: Fifty-six pregnant women attending their first appointment at the GDM clinic and 60 low-risk healthy pregnant controls attending their routine antenatal clinics were recruited and assigned to three groups: GDM Metformin (GDM-M), GDM Diet (GDM-D) and Control. Non-invasive assessment of maternal haemodynamics, using recognised measures of arterial stiffness and central blood pressure (Arteriograph®), were undertaken under controlled conditions within four gestational windows: antenatal; AN1 (26-28 weeks), AN2 (32-34 weeks) and AN3 (37-40 weeks), and postnatal (PN) (6-8 weeks after delivery). Read More

    Resolution of severe fetal distress following treatment of maternal diabetic ketoacidosis.
    BMJ Case Rep 2018 Mar 9;2018. Epub 2018 Mar 9.
    Singapore General Hospital, Singapore.
    Diabetic ketoacidosis (DKA) during pregnancy is a serious metabolic complication of diabetes with high mortality and morbidity if not detected and treated immediately. We report a case of a woman with type 1 diabetes mellitus who had poorly controlled diabetes in the first half of pregnancy and developed DKA at 29 weeks gestation. At presentation, she had a pathological fetal heart tracing but delivery was delayed for maternal stabilisation and reversal of acidosis. Read More

    Outcomes for Women with Gestational Diabetes Treated with Metformin: A Retrospective, Case-Control Study.
    J Clin Med 2018 Mar 9;7(3). Epub 2018 Mar 9.
    Department of Diabetes, Endocrinology and Metabolism, Level 3, Acute Services Building, Royal North Shore Hospital, St Leonards, Sydney NSW 2065, Australia.
    Metformin is increasingly being used a therapeutic option for the management of gestational diabetes mellitus (GDM). The aim of this study was to compare the maternal characteristics and perinatal outcomes of women with GDM treated with metformin (with or without supplemental insulin) with those receiving other management approaches. A retrospective, case-control study was carried out and 83 women taking metformin were matched 1:1 with women receiving insulin or diet and lifestyle modification alone. Read More

    Pre-Pregnancy Fitness and Risk of Gestational Diabetes: A Longitudinal Analysis.
    Med Sci Sports Exerc 2018 Mar 8. Epub 2018 Mar 8.
    Department of Health and Human Physiology, University of Iowa, Iowa City, IA.
    Purpose: To assess the associations of pre-pregnancy cardiorespiratory fitness, moderate-to vigorous-intensity physical activity (MVPA), and time spent watching television with subsequent development of gestational diabetes mellitus (GDM).

    Methods: Participants were 1,333 women enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study who did not have diabetes either at baseline (1985-86) or prior to births occurring after baseline. Baseline fitness was estimated using a graded symptom-limited maximal exercise treadmill test and expressed in metabolic equivalent (MET) units. Read More

    Prevalence of diabetes five years after having gestational diabetes during pregnancy - Croatian national study.
    Prim Care Diabetes 2018 Mar 5. Epub 2018 Mar 5.
    University Hospital Merkur, Zajčeva 19, 10000 Zagreb, Croatia. Electronic address:
    Aims: The aim of this study was to determine the prevalence of diabetes among women 5 years after having gestational diabetes during pregnancy. Also, we sought to determine whether women who develop diabetes after GD during pregnancy differ from women who do not develop diabetes after GD during pregnancy.

    Methods: This longitudinal study was performed using data from medical birth certificates and CroDiab diabetes registry. Read More

    Interactions among insulin resistance, inflammation factors, obesity-related gene polymorphisms, environmental risk factors, and diet in the development of gestational diabetes mellitus.
    J Matern Fetal Neonatal Med 2018 Mar 8:1-9. Epub 2018 Mar 8.
    a Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University , Zhengzhou, Henan Province , China.
    Purpose: The aim of this study was to investigate the correlations and interactions between the polymorphisms of insulin resistance-related genes (ADIPOQ rs2241766), inflammation factors (TNF-α rs1800629, IL-6 rs1800795), obesity-related genes (GNB3 rs5443, ADRB rs1042714), and risk factors for gestational diabetes mellitus (GDM) such as diet structure in the development of GDM.

    Materials And Methods: This research was conducted among women who visited the third-affiliate hospital of Zhengzhou University for pregnancy checkups from 1 June 2014 to 30 December 2014. Based on the results of a 75-g glucose tolerance test (OGTT), 140 pregnant women with GDM were randomly selected as a part of the GDM group and140 healthy, pregnant women as part of the control group. Read More

    Pan Afr Med J 2017 10;28:126. Epub 2017 Oct 10.
    Département de Gynécologie Obstétrique, CHU Ibn El Jazzar, Kairouan, Tunisie.
    The delivery of a macrosomic infant is a relatively common situation. It can put mother and fetus at high risk. The main maternal complications are the increase in cesarean rates, postpartum hemorrhage and cervicovaginal traumatic lacerations. Read More

    Increased Risk of Pregnancy Complications After Stroke: The FUTURE Study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation).
    Stroke 2018 Mar 6. Epub 2018 Mar 6.
    From the Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Center for Neuroscience (M.E.v.A., M.d.V., R.M.A., H.S., E.J.v.D., F.-E.d.L.) and Department of Cardiology (M.J.v.d.V.), Radboud University Nijmegen Medical Center, the Netherlands; Center for Neurology and Neurorehabilitation, State Hospital, Switzerland (N.A.M.M.M.); Department of Neurology, St. Elisabeth Hospital, the Netherlands (N.E.S.); Division of Woman and Baby, Birth Center, University Utrecht Medical Center, the Netherlands (R.d.H.); and German Center for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany (L.C.A.R.-J.).
    Background And Purpose: The study goal was to investigate the prevalence of pregnancy complications and pregnancy loss in women before, during, and after young ischemic stroke/transient ischemic attack.

    Methods: In the FUTURE study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation), a prospective young stroke study, we assessed the occurrence of pregnancy, miscarriages, and pregnancy complications in 223 women aged 18 to 50 years with a first-ever ischemic stroke/transient ischemic attack. Pregnancy complications (gestational hypertension, diabetes mellitus, preeclampsia, and hemolysis, elevated liver enzymes, low platelet count syndrome) were assessed before, during, and after stroke using standardized questionnaires. Read More

    Barriers to Exclusive Breastfeeding Among Women With Gestational Diabetes Mellitus in the United States.
    J Obstet Gynecol Neonatal Nurs 2018 Mar 3. Epub 2018 Mar 3.
    Objective: To identify differences in breastfeeding-related knowledge, attitudes, beliefs, and experiences between women with gestational diabetes mellitus (GDM) and women without GDM.

    Design: Cross-sectional and prospective cohort study.

    Setting: Secondary analysis of data from the U. Read More

    Vaginal anti-mycotics and the risk for spontaneous abortions.
    Am J Obstet Gynecol 2018 Mar 3. Epub 2018 Mar 3.
    Department of Public Health; Department of Faculty of Health Sciences, Ben-Gurion University of the Negev. Electronic address:
    Background: Spontaneous abortions are the most common complication of pregnancy. Clotrimazole and miconazole are widely used vaginal-anti-mycotic agents used for the treatment of vulvovaginal candidiasis. A previous study has suggested an increased risk of miscarriage associated with these azoles, which may lead health professionals to refrain from their use even if clinically indicated. Read More

    EADSG Guidelines: Insulin Therapy in Diabetes.
    Diabetes Ther 2018 Mar 5. Epub 2018 Mar 5.
    MKPGMS-Uganda Martyrs University | St. Francis Hospital, Nsambya, Kampala, Uganda.
    A diagnosis of diabetes or hyperglycemia should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) (A). Typically, patients with T1DM will require initiation with multiple daily injections at the time of diagnosis. Read More

    Metabolomic profiling of women with gestational diabetes mellitus and their offspring: Review of metabolomics studies.
    J Diabetes Complications 2018 Jan 31. Epub 2018 Jan 31.
    Department of Public Health Sciences, Clemson University, Clemson, SC, United States. Electronic address:
    Background: Gestational diabetes mellitus (GDM) reflects an increased risk of developing type 2 diabetes (T2D) after pregnancy in women. Offspring born to mothers with GDM are at an elevated risk of obesity and T2D at a young age. Currently, there are lack of ways for identifying women in early pregnancy who are at risk of developing GDM. Read More

    Which criteria should be used for starting pharmacologic therapy for management of gestational diabetes in pregnancy? Evidence from randomized controlled trials.
    J Matern Fetal Neonatal Med 2018 Mar 20:1-10. Epub 2018 Mar 20.
    c Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine , Sidney Kimmel Medical College of Thomas Jefferson University , Philadelphia , PA , USA.
    Introduction: There is inconclusive evidence to support any specific criteria for starting pharmacologic therapy after diet in women with gestational diabetes mellitus (GDM). We aimed to analyze the most used criteria for starting pharmacologic treatment for patients with GDM.

    Material And Methods: Electronic databases were searched from their inception to September 2017. Read More

    Pre-pregnancy consumption of starchy vegetables and legumes and risk of gestational diabetes mellitus among Tehranian women.
    Diabetes Res Clin Pract 2018 Mar 2;139:131-138. Epub 2018 Mar 2.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
    Aims: The aim of this study was to investigate the association between legumes and starchy vegetables, including 1. potatoes and 2. other starchy vegetables (corn, squash, green pea, and green lima beans), and GDM among Tehranian women. Read More

    The role of obesity in the risk of gestational diabetes among immigrant and U.S.-born women in New York City.
    Ann Epidemiol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY; Women's Health Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
    Purpose: To examine if the role of obesity in the risk of gestational diabetes differs between immigrant and U.S.-born women. Read More

    Pharmacological treatment of gestational diabetes mellitus: point/counterpoint.
    Am J Obstet Gynecol 2018 Feb 28. Epub 2018 Feb 28.
    Knoxville, NY. Electronic address:
    Controversies persist over the most efficacious pharmacologic treatment for gestational diabetes mellitus. For purposes of accuracy in this article, the individual American College of Obstetricians and Gynecologists Practice Bulletin and American Diabetes Association Standards of Medical Care positions on each issue are quoted and then deliberated with evidence of counter claims presented in point/counterpoint. This is a review of all the relevant evidence for the most holistic picture possible. Read More

    Optimal Gestational Weight Gain for Women with Gestational Diabetes and Morbid Obesity.
    Matern Child Health J 2018 Mar 1. Epub 2018 Mar 1.
    Diabetes and Pregnancy Unit, Department of Obstetrics, La Paz University Hospital, Madrid, Spain.
    Objectives: Our aim was to investigate the greatest gestational weight gain (GWG) without adverse pregnancy complications in women with gestational diabetes mellitus (GDM) and morbid obesity.

    Methods: An observational retrospective study including 3284 patients with single pregnancies and GDM was completed. Of the patients, 131 (4. Read More

    Long-term BMI and growth profiles in offspring of women with gestational diabetes.
    Diabetologia 2018 Feb 28. Epub 2018 Feb 28.
    Department of Internal Medicine and Infectious Diseases, the University Medical Center Utrecht, Utrecht, the Netherlands.
    Aims/hypothesis: Gestational diabetes mellitus (GDM) is reported to be associated with childhood obesity, however the magnitude of this association and relation to intrauterine growth is uncertain. We, therefore, aimed to assess whether the growth trajectories of large for gestational age (LGA) and non-LGA offspring of mothers with GDM (OGDM) are different until early adolescence. We also aimed to explore whether growth trajectories of OGDM differ from those of offspring of mothers with type 1 or 2 diabetes (ODM1, ODM2). Read More

    Increased secreted frizzled-related protein 4 and ficolin-3 levels in gestational diabetes mellitus women.
    Endocr J 2018 Feb 27. Epub 2018 Feb 27.
    Department of Prenatal Diagnosis Laboratory, Changzhou Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, China.
    By biochemical and epidemiological similarity with type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM) has some overlap between prediction markers and risk factors of T2DM. The present study aimed to establish that secreted frizzled-related protein 4 (SFRP4) and ficolin-3 levels, which have been linked to insulin resistance and the development of T2DM, are elevated in GDM women. A longitudinal prospective cohort study of 86 GDM and 273 normal glucose tolerant (NGT) pregnant women was performed. Read More

    Metformin use in PCOS pregnancies increases the risk of offspring overweight at 4 years of age; follow-up of two RCTs.
    J Clin Endocrinol Metab 2018 Feb 27. Epub 2018 Feb 27.
    Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
    Context: Metformin is used in pregnancy in women with gestational diabetes mellitus, polycystic ovary syndrome (PCOS) and obesity. Metformin passes the placenta.

    Objective: To explore the effects of metformin use in PCOS pregnancies on offspring growth to 4 years of age. Read More

    Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis.
    PLoS Med 2018 Feb 28;15(2):e1002507. Epub 2018 Feb 28.
    Section of Paediatrics, Department of Medicine, Imperial College London, London, United Kingdom.
    Background: There is uncertainty about the influence of diet during pregnancy and infancy on a child's immune development. We assessed whether variations in maternal or infant diet can influence risk of allergic or autoimmune disease.

    Methods And Findings: Two authors selected studies, extracted data, and assessed risk of bias. Read More

    Improving cardiometabolic and mental health in women with gestational diabetes mellitus and their offspring: study protocol for, a randomised controlled trial.
    BMJ Open 2018 02 27;8(2):e020462. Epub 2018 Feb 27.
    Institute of Higher Education and Research in Healthcare (IUFRS), University of Lausanne, Lausanne, Switzerland.
    Introduction: Gestational diabetes mellitus (GDM) carries prenatal and perinatal risk for the mother and her offspring as well as longer-term risks for both the mother (obesity, diabetes, cardiovascular disease) and her child (obesity, type 2 diabetes). Compared with women without GDM, women with GDM are twice as likely to develop perinatal or postpartum depression. Lifestyle interventions for GDM are generally limited to physical activity and/or nutrition, often focus separately on the mother or the child and take place either during or after pregnancy, while their results are inconsistent. Read More

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