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    Presence of diabetes-specific autoimmunity in women with gestational diabetes mellitus (GDM) predicts impaired glucose regulation at follow-up.
    J Endocrinol Invest 2018 Jan 16. Epub 2018 Jan 16.
    Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, 00161, Rome, Italy.
    Purpose: Gestational diabetes mellitus (GDM) is the most frequent complication of pregnancy; around 10% of GDM cases may be determined by autoimmunity, and our aims were to establish the role of autoimmunity in a population of Sardinian women affected by GDM, to find predictive factors for autoimmune GDM, and to determine type 1 diabetes (T1D) auto-antibodies (Aabs) together with glucose tolerance after a mean 21.2 months of follow-up.

    Methods: We consecutively recruited 143 women affected by GDM and 60 without GDM; clinical data and pregnancy outcomes were obtained by outpatient visit or phone recall. Read More

    Effect of gene-lifestyle interaction on gestational diabetes risk.
    Oncotarget 2017 Dec 6;8(67):112024-112035. Epub 2017 Dec 6.
    Almazov National Medical Research Centre, Saint Petersburg, Russia.
    We hypothesized that the association of certain lifestyle parameters with gestational diabetes mellitus (GDM) risk would depend on susceptibility loci. In total, 278 Russian women with GDM and 179 controls completed questionnaires about lifestyle habits (food consumption, physical activity and smoking). GDM was diagnosed according to the criteria of the International Association of Diabetes and Pregnancy Study Groups. Read More

    The diversity of gestational diabetes - a therapeutic challenge.
    Eur J Endocrinol 2018 Jan 16. Epub 2018 Jan 16.
    E Qvigstad, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Rikshospitalet , Oslo, Norway
    Metformin as the first drug of choice for glucose lowering in gestational diabetes (GDM) is still controversial, despite recent publications reporting similar outcomes in comparison to insulin, both for offspring and mothers. The use of metformin during pregnancy is increasing and several recent guidelines recommend metformin use in GDM pregnancies. Background, current metformin use and unresolved concerns are discussed in the context of the article from Gante et al. Read More

    Relation between cadmium exposure and gestational diabetes mellitus.
    Environ Int 2018 Jan 12. Epub 2018 Jan 12.
    Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:
    Background: Cadmium (Cd) has been associated with type 2 diabetes in general population. However, the role of Cd in the occurrence of Gestational diabetes mellitus (GDM) remains unclear.

    Objectives: Our study was aimed at investigating whether Cd exposure during pregnancy was associated with increased risk of GDM. Read More

    Asymptomatic bacteriuria and urinary tract infection in pregnant women with and without diabetes: Cohort study.
    Eur J Obstet Gynecol Reprod Biol 2017 Dec 7. Epub 2017 Dec 7.
    Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
    Objective: To compare the prevalence of asymptomatic bacteriuria (ASB) and the incidence of urinary tract infection (UTI) in pregnant women with and without diabetes mellitus (DM) or gestational DM (GDM).

    Study Design: We performed a cohort study in five hospitals and two midwifery clinics in the Netherlands. Pregnant women with and without DM or GDM were screened for the presence of ASB around 12 and 32 weeks' gestation. Read More

    Obstetric complications after frozen versus fresh embryo transfer in women with polycystic ovary syndrome: results from a randomized trial.
    Fertil Steril 2018 Jan 12. Epub 2018 Jan 12.
    Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; The Key Laboratory of Reproductive Endocrinology of Ministry of Education, and National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Key Laboratory of Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China. Electronic address:
    Objective: To evaluate the effect of frozen embryo transfer on maternal and neonatal complications of singleton and twin pregnancies compared with fresh embryo transfer in women with polycystic ovary syndrome (PCOS).

    Design: A secondary analysis of a multicenter, randomized, controlled trial comparing live birth after frozen vs. fresh embryo transfer (FreFro-PCOS). Read More

    Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study.
    PLoS Med 2018 Jan 16;15(1):e1002488. Epub 2018 Jan 16.
    Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom.
    Background: Gestational diabetes mellitus (GDM) is associated with developing type 2 diabetes, but very few studies have examined its effect on developing cardiovascular disease.

    Methods And Findings: We conducted a retrospective cohort study utilizing a large primary care database in the United Kingdom. From 1 February 1990 to 15 May 2016, 9,118 women diagnosed with GDM were identified and randomly matched with 37,281 control women by age and timing of pregnancy (up to 3 months). Read More

    Circulating adipokines and mRNA expression in adipose tissue and the placenta in women with gestational diabetes mellitus.
    Peptides 2018 Jan 11. Epub 2018 Jan 11.
    2nd Department of Internal Medicine, Research Institute and Diabetes Center, National and Kapodistrian University of Athens, Medical School, University General Hospital Attikon, Rimini 1, 12462 Haidari, Athens, Greece.
    Maternal adipose tissue and the placenta secrete various molecules commonly called adipokines such as chemerin, omentin-1, visfatin, adiponectin, and leptin that are important players in the pathogenesis of insulin resistance. Gestational diabetes mellitus (GDM) is defined as a state of glucose intolerance characterized by β-cell dysfunction and insulin resistance. To examine whether circulating adipokines and their mRNA expression in the adipose tissue and the placenta are altered in GDM pregnancy, we compared 15 GDM women [obese (BMI > 30) and non-obese (BMI < 30)] to 23 NGT (normal glucose tolerance) women [obese and non-obese], at the time of the Cesarean section. Read More

    The Health Behaviors of Ethnically Diverse Women at Increased Risk of Gestational Diabetes: The Behaviors Affecting Baby and You (B.A.B.Y.) Study.
    Matern Child Health J 2018 Jan 15. Epub 2018 Jan 15.
    Department of Biostatistics & Epidemiology, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA, USA.
    Objectives Cigarette smoking, low physical activity, and sedentary behavior are modifiable risk factors for adverse pregnancy outcomes. However, only one study has evaluated predictors of these health risk behaviors among women at high risk for gestational diabetes mellitus (GDM). Therefore, our goal was to examine predictors of smoking, low physical activity, and sedentary behavior during pregnancy in an ethnically diverse high risk cohort. Read More

    Association of Dietary Pattern during Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study in Northern China.
    Biomed Environ Sci 2017 Dec;30(12):887-897
    Department of Maternal, Child and Adolescent Health, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China.
    Objective: To examine the association of maternal dietary patterns during pregnancy with gestational diabetes mellitus (GDM) in northern China.

    Methods: The dietary intakes of pregnant women were recorded twice by 24-hour dietary recalls for three days prior to having been diagnosed with GDM, at 5-15 and 24-28 gestational weeks, respectively. GDM was diagnosed, and serum glycosylated hemoglobin (HbA1c) was measured at 24-28 weeks. Read More

    [Diet and nutrition interventions prevent gestational diabetes mellitus].
    Zhonghua Yu Fang Yi Xue Za Zhi 2018 Jan;52(1):101-106
    National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention; Key Laboratory of Trace Element Nutrition, National Health and Family Planning Commission, Beijing 100050, China.
    Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, with rising trend over the years. Dietary nutrient intake (protein, fat and fatty acids, carbohydrate, vitamin D, vitamin E, iron, zinc, selenium and inositol et al.), dietary pattern and probiotics may be related to GDM occurrence. Read More

    miR-494 protects pancreatic β-cell function by targeting PTEN in gestational diabetes mellitus.
    EXCLI J 2017 12;16:1297-1307. Epub 2017 Dec 12.
    Department of Obstetrics and Gynecology; Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, China.
    Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications characterized by insulin resistance and pancreatic β-cell dysfunction. Increasing evidence suggests that microRNAs (miRNAs) play key roles in the diverse types of diabetes, including GDM. However, the underlying mechanisms remain largely unknown. Read More

    Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis.
    Fertil Steril 2018 Jan 11. Epub 2018 Jan 11.
    Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, Hunan, People's Republic of China.
    Objective: To provide an updated comparison of pregnancy-related complications and adverse perinatal outcomes of pregnancies conceived after frozen embryo transfer (FET) versus fresh embryo transfer (fresh ET).

    Design: Meta-analysis.

    Setting: University. Read More

    Obesity and abnormal glucose tolerance in offspring of diabetic mothers: A systematic review and meta-analysis.
    PLoS One 2018 12;13(1):e0190676. Epub 2018 Jan 12.
    Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
    Background: Rising prevalence of childhood obesity and type 2 diabetes mellitus (T2DM) is an emerging public health issue.

    Objectives: To investigate the association of maternal hyperglycemia exposure during pregnancy with obesity and abnormal glucose tolerance in offspring, and the age at occurrence.

    Methods: We searched MEDLINE and EMBASE for observational studies on obesity and diabetes in offspring of diabetic mothers (gestational diabetes mellitus (GDM), type 1 diabetes mellitus (T1DM) and T2DM), and those on non-diabetic mothers. Read More

    Nutrigenetic variants and cardio-metabolic risk in women with or without Gestational Diabetes.
    Diabetes Res Clin Pract 2018 Jan 8. Epub 2018 Jan 8.
    Department of Medicine and Aging, School of Medicine and Health Sciences, "G. d'Annunzio" University, Chieti-Pescara, Chieti, Italy. Electronic address:
    Aim: Gestational diabetes mellitus (GDM) is the most frequent metabolic disorder in pregnancy and it can be considered a silent risk associated to T2DM and CVD later in life. The aim of this study was to investigate the association of clinical parameters with nine single nucleotide polymorphisms (SNPs) involved with nutrients and metabolism in women with or without GDM in order to identify potential routine clinical markers for early prevention.

    Methods: Nine gene variants associated with nutrients and metabolism, namely PPARG2 rs1801282 (C>G); PPARGC1A rs8192678 (C>T); TCF7L2 rs7903146 (C>T); LDLR rs2228671 (C>T); MTHFR rs1801133 (C>T); APOA5 rs662799 (T>C); GCKR rs1260326 (C>T); FTO rs9939609 (T>A); MC4R rs17782313 (T>C) were genotyped in 104 GDM cases and 124 controls using High Resolution Melting (HRM) analysis. Read More

    How safe is metformin when initiated in early pregnancy ? A retrospective 5-year study of pregnant women with Gestational Diabetes mellitus from India.
    Diabetes Res Clin Pract 2018 Jan 8. Epub 2018 Jan 8.
    Department of Endocrinology, Diabetes and Metabolism, Christian Medical College (CMC) Vellore, India.
    Background: The initiation of metformin in early pregnancy in Gestational Diabetes mellitus(GDM) remains controversial. The aim of our study was to assess the influence of Metformin on maternal and fetal outcomes when initiated within the first trimester of pregnancy in GDM.

    Methods And Materials: A retrospective analysis of 540 women with diabetes complicating pregnancy (IADPSG criteria) over five years(January 2011 to May 2016)was done. Read More

    Experiences of gestational diabetes and gestational diabetes care: a focus group and interview study.
    BMC Pregnancy Childbirth 2018 Jan 11;18(1):25. Epub 2018 Jan 11.
    Adult Nursing, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK.
    Background: Gestational diabetes mellitus (GDM) is an increasingly common condition of pregnancy. It is associated with adverse fetal, infant and maternal outcomes, as well as an increased risk of GDM in future pregnancies and type 2 diabetes for both mother and offspring. Previous studies have shown that GDM can result in an emotionally distressing pregnancy, but there is little research on the patient experience of GDM care, especially of a demographically diverse UK population. Read More

    [Obstetric outcome in pregnancy complained with pulmonary hypertension].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(47):3711-3715
    Department of Obstetrics and Gynecology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
    Objective: To identify whether pregnancy outcomes vary by the severity of pulmonary hypertension. Methods: A retrospective study was conducted on 78 cases of pregnancies complained with pulmonary hypertension who delivered in the First Affiliated Hospital, Sun Yat-sen University from 2006 to 2016.The selected cases were divided into three groups according to severity of pulmonary hypertension: mild pulmonary hypertension group (mild PAH group) was defined as a mean pulmonary artery pressure 30-49 mmHg, moderate pulmonary hypertension (moderate PAH group) as mean pulmonary artery pressure 50-69 mmHg and severe pulmonary hypertension (severe PAH group) as mean pulmonary artery pressure 70 mmHg or greater. Read More

    [Clinical analysis of 105 intrauterine fetal deaths in 17 years].
    Zhonghua Fu Chan Ke Za Zhi 2017 Dec;52(12):818-821
    Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.
    Objective: To study the cause of intrauterine fetal death (IUFD) in 17 years. Methods: From June 1(st), 2000 to May 31(st), 2017, 65 621 women delivered in Peking University First Hospital. Clinical data of 105 cases of IUFD (including 82 singleton pregnancies and 23 twin pregnancies) during the 17 years were analyzed retrospectively. Read More

    The Women's Health Diagnostic Gap.
    Endocrinology 2018 Feb;159(2):776-778
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
    Pregnancy remains a significant health risk to women in both developed and underdeveloped countries. Worldwide, 10 to 20 million women have pregnancy complications including ectopic pregnancy, preterm birth, gestational diabetes mellitus, and hypertensive states, including preeclampsia. Despite advancements in women's health research, there is a large gap in the diagnostic tools available to screen, diagnose, and monitor these conditions. Read More

    Pregnancy-Associated Hypertension and Offspring Cardiometabolic Health.
    Obstet Gynecol 2018 Jan 9. Epub 2018 Jan 9.
    George Washington University Biostatistics Center, Washington, DC; and the Departments of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, University of Utah Health Sciences Center, Salt Lake City, Utah, University of Texas Southwestern Medical Center, Dallas, Texas, Columbia University, New York, New York, Brown University, Providence, Rhode Island, University of Alabama at Birmingham, Birmingham, Alabama, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio, University of Texas Medical Branch, Galveston, Texas, Northwestern University, Chicago, Illinois, and University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
    Objective: To evaluate whether pregnancy-associated hypertension (gestational hypertension and preeclampsia) was associated with the cardiometabolic health of young offspring.

    Methods: This was a prospective observational follow-up study from 2012 to 2013 of children born to women previously enrolled in a mild gestational diabetes mellitus treatment trial or nongestational diabetes mellitus observational study. At 5-10 years after birth, children were examined and fasting blood samples obtained to determine the following cardiometabolic risk factors: blood pressure (BP), high-density lipoprotein cholesterol, triglycerides, glucose, homeostatic model assessment of insulin resistance, waist circumference, and body mass index (BMI). Read More

    The Association Between Low 50 g Glucose Challenge Test Values and Adverse Pregnancy Outcomes.
    J Womens Health (Larchmt) 2018 Jan 11. Epub 2018 Jan 11.
    2 Institute of Women's Life Medical Science, Yonsei University College of Medicine , Seoul, Republic of Korea.
    Background: The implications of low values on the 50 g glucose challenge test (GCT) in pregnancy are not clearly defined. Few studies have evaluated the influence of maternal low GCT values on obstetrical outcomes. This study aimed to compare pregnancy outcomes between women with low 50 g GCT values and those with normal values. Read More

    Impact of new diagnostic criteria for gestational diabetes.
    J Obstet Gynaecol Res 2018 Jan 11. Epub 2018 Jan 11.
    Mackay Base Hospital, Mackay, Australia.
    Aim: In January 2015, the diagnostic and therapeutic criteria for gestational diabetes changed, with the goal of increasing the sensitivity of diagnosis and improving overall glycemic control, and thus reducing adverse pregnancy outcomes. Our primary aim was to evaluate the effect of the new guidelines on the incidence of diagnosis of gestational diabetes and the incidence of therapeutic interventions. Our secondary aim was to look at the incidence of adverse pregnancy outcomes. Read More

    Correlation Between Third Trimester Glycemic Variability in Non-Insulin-Dependent Gestational Diabetes Mellitus and Adverse Pregnancy and Fetal Outcomes.
    J Diabetes Sci Technol 2018 Jan 1:1932296817752374. Epub 2018 Jan 1.
    1 Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: Gestational diabetes mellitus (GDM) is a pregnancy-related metabolic complication. Despite optimal glycemic control from self-monitoring blood glucose (SMBG) in non-insulin-dependent GDM, variations in pregnancy outcomes persist. Glycemic variability is believed to be a factor that causes adverse pregnancy outcomes. Read More

    Association between fetal fraction on cell-free DNA testing and first trimester markers for pre-eclampsia.
    Ultrasound Obstet Gynecol 2018 Jan 10. Epub 2018 Jan 10.
    Discipline of Obstetrics, Gynaecology and Neonatology, University of Sydney, New South Wales, Australia.
    Aims: To evaluate the association of fetal fraction on cell-free DNA (cfDNA) testing with first trimester markers for pre-eclampsia and to investigate a possible association of low fetal fraction with increased risk for pre-eclampsia (PE) and fetal growth restriction (FGR).

    Methods: This was a retrospective cohort study including all women with singleton pregnancies who had risk calculation for PE and FGR between 11+0 and 13+6 weeks' gestation and also decided to have cfDNA as a primary or secondary screening test for chromosomal abnormalities at any gestational age in two Fetal Medicine clinics in Sydney and Melbourne, Australia, between March 2013 and May 2017. Logarithmically transformed fetal fraction results were adjusted for gestational age and maternal characteristics. Read More

    Development and Evaluation of a Mobile Personalized Blood Glucose Prediction System for Patients With Gestational Diabetes Mellitus.
    JMIR Mhealth Uhealth 2018 Jan 9;6(1):e6. Epub 2018 Jan 9.
    Institute of Endocrinology, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation.
    Background: Personalized blood glucose (BG) prediction for diabetes patients is an important goal that is pursued by many researchers worldwide. Despite many proposals, only a few projects are dedicated to the development of complete recommender system infrastructures that incorporate BG prediction algorithms for diabetes patients. The development and implementation of such a system aided by mobile technology is of particular interest to patients with gestational diabetes mellitus (GDM), especially considering the significant importance of quickly achieving adequate BG control for these patients in a short period (ie, during pregnancy) and a typically higher acceptance rate for mobile health (mHealth) solutions for short- to midterm usage. Read More

    Combined Metabolomic Analysis of Plasma and Urine Reveals AHBA, Tryptophan and Serotonin Metabolism as Potential Risk Factors in Gestational Diabetes Mellitus (GDM).
    Front Mol Biosci 2017 21;4:84. Epub 2017 Dec 21.
    Department of Ecogenomics and Systems Biology, University of Vienna, Vienna, Austria.
    Gestational diabetes mellitus during pregnancy has severe implications for the health of the mother and the fetus. Therefore, early prediction and an understanding of the physiology are an important part of prenatal care. Metabolite profiling is a long established method for the analysis and prediction of metabolic diseases. Read More

    Circulating microRNA (miRNA) Expression Profiling in Plasma of Patients with Gestational Diabetes Mellitus Reveals Upregulation of miRNA miR-330-3p.
    Front Endocrinol (Lausanne) 2017 12;8:345. Epub 2017 Dec 12.
    Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
    Gestational diabetes mellitus (GDM) is characterized by insulin resistance accompanied by low/absent beta-cell compensatory adaptation to the increased insulin demand. Although the molecular mechanisms and factors acting on beta-cell compensatory response during pregnancy have been partially elucidated and reported, those inducing an impaired beta-cell compensation and function, thus evolving in GDM, have yet to be fully addressed. MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs, which negatively modulate gene expression through their sequence-specific binding to 3'UTR of mRNA target. Read More

    Analysis of sequential hair segments reflects changes in the metabolome across the trimesters of pregnancy.
    Sci Rep 2018 Jan 8;8(1):36. Epub 2018 Jan 8.
    Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    The hair metabolome has been recognized as a valuable source of information in pregnancy research, as it provides stable metabolite information that could assist with studying biomarkers or metabolic mechanisms of pregnancy and its complications. We tested the hypothesis that hair segments could be used to reflect a metabolite profile containing information from both endogenous and exogenous compounds accumulated during the nine months of pregnancy. Segments of hair samples corresponding to the trimesters were collected from 175 pregnant women in New Zealand. Read More

    Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis.
    BMC Pregnancy Childbirth 2018 Jan 8;18(1):14. Epub 2018 Jan 8.
    Department of Obstetrics and Gynecology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.
    Background: Probiotics are living microorganisms that, when administered in adequate amounts, confer a health benefit. It has been speculated that probiotics might help prevent preterm birth, but in two previous systematic reviews possible major increases in this risk have been suggested. Our objective was to perform a systematic review and meta-analysis of the risk of preterm birth and other adverse pregnancy outcomes in pregnant women taking probiotics, prebiotics or synbiotics. Read More

    Trends in Obstetric Intervention and Pregnancy Outcomes of Canadian Women With Diabetes in Pregnancy From 2004 to 2015.
    J Endocr Soc 2017 Dec 20;1(12):1540-1549. Epub 2017 Nov 20.
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
    Context: Multiple consensus statements decree that women with diabetes mellitus should have comparable birth outcomes to women without diabetes mellitus; however, there is a scarcity of contemporary population-based studies on this issue.

    Objective: To examine temporal trends in obstetric interventions and perinatal outcomes in a population-based cohort of women with type 1, type 2, or gestational diabetes mellitus compared with a control population.

    Design: Cross-sectional study. Read More

    Intrapartum and neonatal mortality among low-risk women in midwife-led versus obstetrician-led care in the Amsterdam region of the Netherlands: a propensity score matched study.
    BMJ Open 2018 Jan 5;8(1):e018845. Epub 2018 Jan 5.
    School of Paediatrics and Reproductive Health, The Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia.
    Objective: To compare intrapartum and neonatal mortality in low-risk term women starting labour in midwife-led versus obstetrician-led care.

    Study Design: We performed a propensity score matched study using data from our national perinatal register, completed with data from medical files. We studied women without major risk factors with singleton pregnancies who gave birth at term between 2005 and 2008 in the Amsterdam region of the Netherlands. Read More

    Corticosteroid Injection for an Orthopedic Complaint in a Female with Gestational Diabetes.
    Sports Med Open 2018 Jan 5;4(1). Epub 2018 Jan 5.
    , Birmingham, USA.
    A female with gestational diabetes presented with hip pain characteristic of meralgia paresthetica and trochanteric bursitis. She had similar episodes prior to pregnancy that were treated successfully with non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroid injections. However, NSAID use during pregnancy poses risks to the fetus and corticosteroids carry a risk of hyperglycemia, especially in those with diabetes. Read More

    Urine albumin is a superior predictor of preeclampsia compared to urine plasminogen in type I diabetes patients.
    J Am Soc Hypertens 2017 Dec 13. Epub 2017 Dec 13.
    Department of Gynecology and Obstetrics, Institute of Clinical Medicine, Aarhus University Hospital Skejby, Denmark.
    Pregnant women with type I diabetes mellitus (T1DM) are at increased risk of developing preeclampsia (PE). Plasminogen is aberrantly filtrated from plasma into tubular fluid in PE patients and activated to plasmin. Plasmin activates the epithelial sodium channel in the collecting ducts potentially causing impaired sodium excretion, suppression of the renin-angiotensin-aldosterone system, and hypertension in PE. Read More

    The prevalence of elevated high-sensitivity C-reactive protein in normal pregnancy and gestational diabetes mellitus.
    J Family Med Prim Care 2017 Apr-Jun;6(2):259-264
    Department of Internal Medicine, Sri Balaji Action Medical Institute, New Delhi, India.
    Objective: The objective of this study is to determine the prevalence of elevated high-sensitivity C-reactive protein (hs-CRP) in normal pregnancy and gestational diabetes mellitus (GDM) and to compare the prevalence in both groups.

    Materials And Methods: We conducted a case-control study between April 2015 and April 2016. Statistical analysis was performed by the SPSS program version 17. Read More

    Comparison of Total Antioxidant Capacity of Saliva in Women with Gestational diabetes mellitus and Non-diabetic Pregnant Women.
    J Clin Exp Dent 2017 Nov 1;9(11):e1282-e1286. Epub 2017 Nov 1.
    Post-graduate Student, Department of oral and maxillofacial surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: Pregnancy is considered a stressful event, results in higher levels of oxidative stress and considerable changes in physiological and metabolic functions such as gestational diabetes mellitus (GDM). Due to the cumulative effect of antioxidants and considering the controversies in this area, this study was undertaken to investigate the total antioxidant capacity (TAC) of saliva in pregnant women whit gestational diabetes in comparison to non-diabetic pregnant women.

    Material And Methods: In this cross-sectional study (2015-16), a total of 31 women with a diagnosis of GDM and 59 non-diabetic pregnant women were included in the diabetic and control groups, respectively. Read More

    Body mass index at 11-13 weeks' gestation and pregnancy complications in a Southern Chinese population: A retrospective cohort study.
    J Matern Fetal Neonatal Med 2018 Jan 4:1-11. Epub 2018 Jan 4.
    a Department of Obstetrics and Gynecology , the Chinese University of Hong Kong , Hong Kong.
    Objective: To assess the association between body mass index (BMI) and adverse pregnancy outcomes.

    Materials And Methods: A multicentre retrospective cohort study was conducted in three hospitals in Hong Kong including 67 248 women with singleton pregnancy at 11-13 weeks between 2010-2016. The relationship between maternal BMI and [1] miscarriage or stillbirth, [2] development of preeclampsia (PE), [3] gestational hypertension (GH), [4] development of gestational diabetes mellitus (GDM), [5] spontaneous preterm delivery (sPTD) < 34 and < 37 weeks, [6] delivery of a small for gestational age (SGA) or large for gestational age (LGA) neonate, [7] caesarean section (CS) and [8] postpartum haemorrhage (PPH) were examined after adjusting for confounding factors. Read More

    New criteria for gestational diabetes mellitus - do they impact the outcome?
    Neuro Endocrinol Lett 2017 Dec 4;38(6):441-448. Epub 2017 Dec 4.
    2nd Department of Obstetrics and Gynecology, Medical University of Warsaw , Poland.
    Objective: The aim of the study was to compare the perinatal outcome of pregnancies in mothers who were diagnosed with gestational diabetes mellitus (GDM) with previous versus current Polish Gynecological Society (PTG) criteria.

    Methods: 475 patients were divided into three groups. In group A, the patients only met the previous PTG criteria for a GDM diagnosis, i. Read More

    Functional Defects of Regulatory T Cell Through Interleukin 10 Mediated Mechanism in the Induction of Gestational Diabetes Mellitus.
    DNA Cell Biol 2018 Jan 3. Epub 2018 Jan 3.
    1 Department of Endocrinology, Affiliated Hospital of Zunyi Medical College , Zunyi, China .
    Gestational diabetes mellitus (GDM) is a metabolic and low-grade inflammatory disease most commonly found in pregnant women with high body mass index and non-Caucasian ethnicities; however, not all women of high-risk groups develop GDM. We hypothesized that regulatory T cells (Tregs) might present a role in suppressing GDM development. To this end, 55 high-risk women at early pregnancy (first trimester) were recruited, and 21 of them developed GDM while the other 34 did not. Read More

    Should pregnant women be excluded from a community-based lifestyle intervention trial? A case study.
    Reprod Health 2017 Dec 14;14(Suppl 3):165. Epub 2017 Dec 14.
    Department of Public Health and Community Medicine, Central University of Kerala, Kasaragod, Kerala, India.
    Kerala, the southernmost Indian state, is known as the diabetes capital of the country. A community-based lifestyle modification program was implemented in the rural areas of Kerala, India, to assess effectiveness in reducing the incidence of type 2 diabetes mellitus (T2DM) among individuals at high risk. High-risk individuals for T2DM were identified through home screening and enrolled into the program after an oral glucose tolerance test to rule out T2DM. Read More

    Prevalence and Determinants of Gestational Diabetes Mellitus: A Cross-Sectional Study in China.
    Int J Environ Res Public Health 2017 Dec 8;14(12). Epub 2017 Dec 8.
    School of Public Health and Management, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, China.
    Objectives: This study aimed to identify the prevalence of gestational diabetes mellitus (GDM) and to examine its associations with social and behavioral factors, maternal body mass index (BMI), anemia, and hypertension. Methods: A cross-sectional analysis was performed on data collected from 2345 pregnant women from 16 hospitals in five selected provinces in mainland China.

    Results: Prevalence of GDM was as follows: overall: 3. Read More

    Gestational diabetes from A to Z.
    World J Diabetes 2017 Dec;8(12):489-511
    Iatriko Paleou Falirou Medical Center, Division of Diabetes and Clinical Research Center, Athens 17562, Greece.
    Gestational diabetes mellitus (GDM) is defined as any degree of hyperglycaemia that is recognized for the first time during pregnancy. This definition includes cases of undiagnosed type 2 diabetes mellitus (T2DM) identified early in pregnancy and true GDM which develops later. GDM constitutes a greater impact on diabetes epidemic as it carries a major risk of developing T2DM to the mother and foetus later in life. Read More

    Attitudes, barriers and enablers to physical activity in pregnant women: a systematic review.
    J Physiother 2018 Jan 27;64(1):24-32. Epub 2017 Dec 27.
    Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, Monash University; Centre for Allied Health Research and Education, Cabrini Health, Melbourne, Australia.
    Question: What are the attitudes, barriers and enablers to physical activity perceived by pregnant women?

    Design: In a systematic literature review, eight electronic databases were searched: AMED, CINAHL, Embase, Joanna Briggs Institute, Medline, PsycInfo, SPORTDiscus (from database inception until June 2016) and PubMed (from 2011 until June 2016). Quantitative data expressed as proportions were meta-analysed. Data collected using Likert scales were synthesised descriptively. Read More

    Early postpartum metabolic syndrome in women with or without gestational diabetes: Results from Life after Gestational Diabetes Ahvaz cohort study.
    Diabetes Metab Syndr 2017 Dec 22. Epub 2017 Dec 22.
    Department of Midwifery, Ardabil University of medical sciences, Ardabil, Iran. Electronic address:
    Aims: This study aimed to determine the prevalence rate of metabolic syndrome and its potential risk factors, 6-12 weeks postpartum in women with GDM compared to women with normal glucose tolerance.

    Methods: LAGAs is an ongoing population-based prospective cohort study that started in March 2015 in Ahvaz, Iran. During 11 months of study progression, 176 women with GDM pregnancy and 86 healthy women underwent a fasting glucose test, 75-g OGTT and fasting lipid tests at 6-12 weeks postpartum. Read More

    Prevalence of Pharamcologically-treated Diabetes in Term Pregnancies in Haryana, India.
    Indian J Endocrinol Metab 2017 Nov-Dec;21(6):926-927
    Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
    Gestational diabetes mellitus (GDM) is common in pregnancy. Epidemiological studies have described the prevalence of GDM in the antenatal period, but do not assess the number of women who require pharmacological therapy at term. This information is important for obstetric care providers and health planners. Read More

    Maternal and Neonatal Outcome in Mothers with Gestational Diabetes Mellitus.
    Indian J Endocrinol Metab 2017 Nov-Dec;21(6):854-858
    Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Introduction: Gestational diabetes mellitus (GDM) is common and is accompanied with other comorbidities. Challenges to treatment exist at our institute as it serves women with low income. This study assessed the burden of comorbidities and the outcome of GDM. Read More

    Characteristics and clinical outcomes of living renal donors in Hong Kong.
    Hong Kong Med J 2017 Dec 29. Epub 2017 Dec 29.
    SH Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
    Introduction: In Asia, few reports are available on the outcomes for living renal donors. We report the short- and long-term clinical outcomes of individuals following living donor nephrectomy in Hong Kong.

    Methods: We retrospectively reviewed the characteristics and clinical outcomes of all living renal donors who underwent surgery from January 1990 to December 2015 at our centre in Hong Kong. Read More

    Clinical significance of neuregulin 4 (NRG4) in gestational diabetes mellitus.
    Gynecol Endocrinol 2017 Dec 28:1-4. Epub 2017 Dec 28.
    f Department of Biochemistry , Adnan Menderes University School of Medicine , Aydin , Turkey.
    Objective: Gestational diabetes mellitus (GDM) is defined as glucose intolerance detected during pregnancy. GDM is increasing worldwide and is associated with adverse maternal and fetal outcomes. Neuregulin 4 (NGR4) is epidermal growth factor like signaling molecule. Read More

    Development of Multimarker Diagnostic Models from Metabolomics Analysis for Gestational Diabetes Mellitus.
    Mol Cell Proteomics 2017 Dec 27. Epub 2017 Dec 27.
    Shanghai Jiao Tong University Affiliated Sixth Peoples Hospital.
    Although metabolomics are desirable to understand the pathophysiology of gestational diabetes mellitus (GDM), comprehensive metabolomic studies of GDM are rare. We aimed to offer a holistic view of metabolites alteration in GDM patients and investigate the possible multimarker models for GDM diagnosis. Biochemical parameters and perinatal data of 131 GDM cases and 138 controls were collected. Read More

    Efficacy of maternal and biological parameters at the time of diagnosis of gestational diabetes mellitus in predicting neonatal morbidity.
    Eur J Obstet Gynecol Reprod Biol 2017 Dec 19;221:113-118. Epub 2017 Dec 19.
    Department of Endocrinology, Centre Hospitalier Departemental, La Roche sur Yon, France.
    Objective: Gestational diabetes mellitus (GDM) is independently associated with an increased risk of maternal-fetal complications. Improved glycemic control allows reducing perinatal morbidity and mortality and, specifically, the risk of macrosomia and shoulder dystocia which are the most common complications associated with GDM. Nonetheless, a need for early antenatal predictor of neonatal morbidity in women suffering from GDM is required. Read More

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