Search our Database of Scientific Publications and Authors

I’m looking for a

    21329 results match your criteria Diabetes Mellitus and Pregnancy

    1 OF 427

    The pathogenesis and pathophysiology of gestational diabetes mellitus: Deductions from a three-part longitudinal metabolomics study in China.
    Clin Chim Acta 2017 Feb 14. Epub 2017 Feb 14.
    Mass Spectrometry Centre, China-Canada-New Zealand Joint Laboratory of Maternal and Foetal Medicine, Chongqing Medical University, Chongqing, China; Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Gestational diabetes mellitus (GDM) is a form of diabetes that is first recognised during pregnancy, with no evidence of pre-existing type 1 or type 2 diabetes. The prevalence of GDM has been rising steadily over the past few decades, coinciding with the ongoing epidemic of obesity and type 2 diabetes. Although GDM normally disappears after delivery, women who have been previously diagnosed with GDM are at a greater risk of developing gestational diabetes in subsequent pregnancies, and type 2 diabetes later in life. Read More

    Awareness of Gestational Diabetes and its Risk Factors among Pregnant Women in Samoa.
    Hawaii J Med Public Health 2017 Feb;76(2):48-54
    Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham.
    Gestational diabetes mellitus (GDM) is a subtype of diabetes mellitus defined as the development, or first recognition, of glucose intolerance during pregnancy. The risk of developing type 2 diabetes mellitus (T2DM) is greater in mothers with GDM compared to the general population. Preventing the development of GDM could help lower the prevalence of T2DM and long-term morbidity in children of affected mothers. Read More

    Gestational diabetes mellitus may be associated with increased risk of breast cancer.
    Br J Cancer 2017 Feb 16. Epub 2017 Feb 16.
    Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
    Background: Although a positive association between type 2 diabetes and breast cancer has been reported, an association with gestational diabetes mellitus (GDM) is less clear.

    Methods: The Sister Study enroled 50 884 women aged 35-74 years, from 2003 through 2009. Cox proportional hazards models were used to estimate breast cancer risk in relation to GDM. Read More

    Screening for diabetes in pregnancy in a regional area with a high Māori population.
    N Z Med J 2017 Feb 17;130(1450):25-31. Epub 2017 Feb 17.
    Clinical Study Coordinator, Medical Service, Bay of Plenty, District Health Board, Tauranga.
    Aims: To identify and document factors associated with screening for diabetes in pregnancy in a regional area with a high Māori population in New Zealand.

    Methods: An audit was undertaken of routine hospital data collected from all 656 women who gave birth, between June and December in 2013 and 2014, in two Mid-North Island hospitals in the Bay of Plenty region.

    Results: Of the 656 woman who gave birth during these periods, only 416 (63%) were screened for diabetes in pregnancy, including 390 (60%) for gestational diabetes mellitus later in pregnancy. Read More

    Is Diabetes Associated with Lower Vitamin C Status in Pregnant Women? A Prospective Study.
    Int J Vitam Nutr Res 2017 Feb 16:1-5. Epub 2017 Feb 16.
    3 Faculty of Health and Medical Sciences, University of Copenhagen.
    Few studies have examined how vitamin C status is affected in diabetic pregnancy and no comparison between normal and diabetic pregnancies has been found. This study evaluated vitamin C status prospectively during pregnancy in women with type 1 diabetes mellitus (n=76), in non-diabetic women (n=60), and in their respective neonates. Vitamin C was lower in diabetic women throughout all trimesters compared to controls (p<0. Read More

    Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study.
    Endocr J 2017 Feb 16. Epub 2017 Feb 16.
    Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.
    Gestational diabetes (GDM) and type 2 diabetes (T2DM) share part of pathomechanism and several T2DM susceptibility genes are demonstrated to be associated with GDM. No information on the genetics of GDM, however, was available in Japanese women. In this study, T2DM risk variants (45 single nucleotide polymorphisms [SNPs] from 36 genes) identified in previous studies were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in a cohort of 171 Japanese women with GDM and 128 normal glucose tolerance (NGT) diagnosed by the new International Association of Diabetes in Pregnancy Study Group criteria. Read More

    Effects of Fish Oil Supplementation on Gestational Diabetes Mellitus (GDM): A Systematic Review.
    Iran Red Crescent Med J 2016 Nov 2;18(11):e24690. Epub 2016 Jul 2.
    Tabriz Health Services Management Research Center, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, IR Iran.
    Context: One of the most common complications of pregnancy is gestational diabetes mellitus (GDM), which is increasing worldwide. Experimental and epidemiological studies have shown that higher intake of n-3 long-chain polyunsaturated fatty acids may decrease the risk of various diseases such as diabetes. The objective of this study was to assess the effect of fish oil supplementation on the prevention and treatment of GDM. Read More

    The fetal cerebro-placental ratio in diabetic pregnancies is influenced more by the umbilical artery rather than middle cerebral artery pulsatility index.
    Eur J Obstet Gynecol Reprod Biol 2017 Feb 3;211:56-61. Epub 2017 Feb 3.
    Mater Research Institute, University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland, QLD 4101, Australia; School of Medicine, The University of Queensland, Brisbane, Australia. Electronic address:
    Objective: This study aimed to assess the relationship between the cerebro-placental ratio (CPR) and intrapartum and perinatal outcomes in pregnancies complicated by pre-existing insulin dependent diabetes (pT1DM) mellitus, pre-existing non-insulin dependent diabetes mellitus (pT2DM) and gestational diabetes mellitus (GDM).

    Study Design: This was a retrospective cohort study of 1281 women with diabetes mellitus birthing at the Mater Mothers' Hospital in Brisbane between 2007 and 2015. The CPR in non-anomalous singleton fetuses was measured between 34+0 and 36+6 weeks gestation and compared between types of DM treatment groups and correlated with intrapartum and perinatal outcomes. Read More

    Biphasic effect of alpha-linolenic acid on glucose-induced dysmorphogenesis and lipoperoxidation in whole rat embryo in culture.
    Biochem Biophys Res Commun 2017 Feb 6. Epub 2017 Feb 6.
    Laboratory of Metabolism of Diabetes Mellitus, Morphology and Function Unit, Mexico. Electronic address:
    Type 1 diabetes mellitus complicated with pregnancy, know as diabetic embryopathy, is the cause of neonatal malformations and low for gestational age neonates. With the use of the whole-embryo culture system, it has been demonstrated that high glucose causes embryo dysmorphogenesis, and that oxidative stress appears to be the main mechanism. In recent years, beneficial effect of omega-3 fatty acids has been demonstrated in various diabetic models, and in diabetic complications. Read More

    Regulation of the novel adipokines/ hepatokines fetuin A and fetuin B in gestational diabetes mellitus.
    Metabolism 2017 Mar 9;68:88-94. Epub 2016 Dec 9.
    University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address:
    Objective: Fetuin B has recently been introduced as a novel adipokine/hepatokine which is significantly increased in hepatic steatosis and mediates impaired insulin action, as well as glucose intolerance. However, regulation of fetuin B in gestational diabetes mellitus (GDM), as well as its longitudinal changes in the peripartum period, have not been elucidated, so far.

    Design And Methods: Circulating fetuin A and fetuin B were quantified in 74 women with GDM and 74 healthy and gestational age-matched controls by enzyme-linked immunosorbent assay during pregnancy (median gestational age: 201days). Read More

    Preliminary validation of an exercise program suitable for pregnant women with abnormal glucose metabolism: inhibitory effects of Tai Chi Yuttari-exercise on plasma glucose elevation.
    J Phys Ther Sci 2016 Dec 27;28(12):3411-3415. Epub 2016 Dec 27.
    Department of Rehabilitation Sciences, Kansai University of Welfare Sciences, Japan; Therapeutic Exercise Research Laboratory, Kansai University of Welfare Sciences, Japan.
    [Purpose] There is insufficient evidence related to exercise programs that are safe and efficacious for pregnant women with abnormal glucose metabolism. Tai Chi Yuttari-exercise is an exercise program with validated safety and efficacy in improving physical function in the elderly. In this study, we investigated this program's inhibitory effects on plasma glucose elevation when it was adapted to a pregnancy model. Read More

    Early age at menarche and gestational diabetes mellitus risk: Results from the Healthy Baby Cohort study.
    Diabetes Metab 2017 Feb 1. Epub 2017 Feb 1.
    Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Hubei, Wuhan, China. Electronic address:
    Aim: Early age at menarche has been reported to increase type 2 diabetes risk, but little is known of its impact on gestational diabetes mellitus (GDM) risk. The aim of this study was to examine the association between age at menarche and plasma glucose levels as well as GDM risk.

    Methods: A total of 6900 pregnant women from the Healthy Baby Cohort Study were included in our analysis. Read More

    A randomized clinical trial of exercise during pregnancy to prevent gestational diabetes mellitus and improve pregnancy outcome in overweight and obese pregnant women.
    Am J Obstet Gynecol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Obstetrics and Gynecology of Peking University First Hospital, Beijing, China. Electronic address:
    Background: Obesity and being overweight are becoming epidemic, and indeed, the proportion of such women of reproductive age has increased in recent times. Being overweight or obese prior to pregnancy is a risk factor for gestational diabetes mellitus (GDM), and increases the risk of adverse pregnancy outcome for both mothers and their offspring. Furthermore, the combination of GDM with obesity/overweight status may increase the risk of adverse pregnancy outcome attributable to either factor alone. Read More

    Maternal Type 1 diabetes activates stress response in early placenta.
    Placenta 2017 Feb 16;50:110-116. Epub 2017 Jan 16.
    Department of Obstetrics and Gynecology, Medical University of Graz, Austria. Electronic address:
    Introduction: Human pregnancy and in particular the first trimester, is a period highly susceptible towards adverse insults such as oxidative stress, which may lead to inadequate embryonic and feto-placental development. Diabetes mellitus is associated with increased oxidative stress caused by hyperglycemia, reactive oxygen species (ROS) production and inflammatory signals. In pregnancy, diabetes elevates the risk for early pregnancy loss, preeclampsia and fetal growth restriction, pathologies that origin from early placental maldevelopment. Read More

    Thiopurines and Methotrexate Use in IBD Patients in a Biologic Era.
    Curr Treat Options Gastroenterol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Gastroenterology, 'Evangelismos-Ophthalmiatreion Athinon-Polycliniki' Hospitals, 45-47 Ypsilantou Street, Kolonaki, 10676, Athens, Greece.
    Opinion Statement: Although we have been living in the era of biologic therapy for several decades, the use of immunomodulators (primarily thiopurines [azathioprine and mercaptopurine] and less so methotrexate) still remains an important component of the inflammatory bowel disease (IBD) pharmaceutical arsenal. Thiopurines as monotherapy exert corticosteroid-sparing effects and can maintain long-term remission in a considerable proportion of patients who have frequent relapses and are or have become mesalazine and/or corticosteroid intolerant or refractory. Withdrawal of thiopurines results in relapse of disease in a significant proportion of patients. Read More

    Biomarkers of oxidative stress in pregnancy complications.
    Biomark Med 2017 Feb 3. Epub 2017 Feb 3.
    School of Medical Science & Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
    Pregnancy complications including pre-eclampsia, gestational-diabetes mellitus, preterm birth and intrauterine growth restriction can cause acute and chronic health problems for the mother and lead to fetal loss or dysregulation of infant physiology. The human placenta is susceptible to oxidative stress and oxidative damage in early gestation contributes to the onset of these conditions later in pregnancy. Current methods of predicting pregnancy complications are limited and although a large number of factors are associated with disease progression, few biomarkers have been used to aid in disease diagnosis early in gestation. Read More

    Towards a European Consensus on Gestational Diabetes Mellitus: A Pragmatic Guide for Diagnosis, Management, and Care. The Polish Diabetes in Pregnancy Study Group and FIGO.
    Ginekol Pol 2017 ;88(1):46-49
    1st Chair and Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland 2nd Chair and Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.

    Preterm Delivery and Maternal Cardiovascular Disease in Young and Middle-Aged Adult Women.
    Circulation 2017 Feb;135(6):578-589
    From Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (L.J.T., J.J.S., P.L.W., E.B.R., S.A.M., J.W.R.-E.); Connors Center for Women's Health and Gender Biology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (L.J.T., J.J.S., J.W.R.-E.); Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (P.L.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (E.B.R., K.J.M.); Division of Adolescent and Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, MA (S.A.M.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA (E.B.R., S.A.M., J.W.R.-E.); Department of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids (S.A.M.); Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (K.M.R.); and Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (K.J.M.).
    Background: Preterm delivery has been shown to be associated with increased risk of cardiovascular disease (CVD), but it is unknown whether this risk remains after adjustment for prepregnancy lifestyle and CVD risk factors.

    Methods: We examined the association between history of having delivered an infant preterm (<37 weeks) and CVD in 70 182 parous women in the Nurses' Health Study II. Multivariable Cox proportional-hazards models were used to estimate hazards ratios (HRs) and 95% confidence intervals (CIs) for CVD events (myocardial infarction and stroke, n=949); we also adjusted for intermediates to determine the proportion of the association between preterm and CVD accounted for by postpartum development of CVD risk factors. Read More

    Acceptability of Virtual Prenatal Visits for Women with Gestational Diabetes.
    Womens Health Issues 2017 Jan 30. Epub 2017 Jan 30.
    Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California. Electronic address:
    Introduction: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy. Current approaches to GDM management and education are labor intensive and costly. Telemedicine offers a potential solution to reduce the time and cost burden of prenatal care for women with GDM. Read More

    Fertility treatments and pediatric neoplasms of the offspring: results of a population-based cohort with a median follow-up of 10 years.
    Am J Obstet Gynecol 2017 Jan 30. Epub 2017 Jan 30.
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Objective: Studies have questioned the long-term health effects of offspring conceived after fertility treatments.

    Methods: We aimed to evaluate whether an association exists between mode of conception (in vitro fertilization, ovulation induction, or spontaneous pregnancy) and neoplasm risk (both benign and malignant tumors) among the offspring; we observed the offspring for up to 18 years.

    Study Design: A population-based cohort analysis was performed that compared the risk for neoplasms among children (up to the age of 18 years) based on mode of conception. Read More

    Patterns of gestational weight gain in early pregnancy and risk of gestational diabetes mellitus.
    Epidemiology 2017 Jan 30. Epub 2017 Jan 30.
    a,d Department of Obstetrics & Gynaecology, University of British Columbia, Vancouver Canada b Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA b,c Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
    Background: Despite a call to study the effect of weight gain pattern on development of gestational diabetes mellitus, few studies have correctly adjusted for independent effects of gain after the first trimester. We used a conditional percentile approach to model the independent association between first and second trimester weight-gain trajectories and development of gestational diabetes.

    Methods: We sampled women delivering singleton infants from 1998-2010 at Magee-Womens Hospital in Pittsburgh, PA (n=124,590) using a case-cohort design. Read More

    Altered oscillation of Doppler-derived renal and renal interlobar venous flow velocities in hypertensive and diabetic patients.
    J Med Ultrason (2001) 2017 Feb 1. Epub 2017 Feb 1.
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Kita-14, Nishi-5, Kita-ku, Sapporo, 060-8648, Japan.
    Background And Purpose: Flow velocity oscillation rate (FVOR) of the renal interlobar vein has been reported to be decreased in patients with urinary obstruction or diabetic nephropathy, and increased in those with hypertension during pregnancy. To clarify the clinical role of the renal interlobar venous FVOR, we investigated the flow velocity patterns of the renal vessels in patients with hypertension (HT) and/or diabetes (DM).

    Methods And Results: Pulsed-wave Doppler sonography was performed in 34 patients: 15 with HT, 10 with DM, and nine with both HT and DM (HT-DM). Read More

    Interventions to Improve Rate of Diabetes Testing Postpartum in Women With Gestational Diabetes Mellitus.
    Curr Diab Rep 2017 Feb;17(2)
    Department of Obstetrics & Gynecology, Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, 02905, USA.
    Purpose Of Review: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. In the USA, four million women are screened annually for GDM in pregnancy in part to improve pregnancy outcomes but also because diagnosis predicts a high risk of future type 2 diabetes mellitus (T2DM). Therefore, among women with GDM, postpartum care should be focused on T2DM prevention. Read More

    Gestational diabetes mellitus and the predisposing factors.
    J Pak Med Assoc 2017 Feb;67(2):261-265
    Department of Physiology, University of Karachi, Karachi, Pakistan.
    Objective: To evaluate the occurrence of gestational diabetes mellitus and its association with demographic and anthropometric variables in pregnant women.

    Methods: This cross-sectional study was conducted at the Aga Khan University Hospital, Abbasi Shaheed Hospital and Memon Hospital in Karachi, from February 2014 to December 2015, and comprised pregnant women who were screened by 75-g 2-hour oral glucose tolerance test, (24-28 weeks of gestation) and classified as per the criteria of the International Association of Diabetes and Pregnancy Study Group. Weight, body mass index and serum glycated haemoglobin levels were measured. Read More

    Association of Pregnancy Complications and Characteristics With Future Risk of Elevated Blood Pressure: The Västerbotten Intervention Program.
    Hypertension 2017 Mar 30;69(3):475-483. Epub 2017 Jan 30.
    From the Division of Cardiology, Department of Medicine, University of California San Francisco (N.I.P.); Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå University, Sweden (M.N.); Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, CA (E.I.); Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden (E.I.); Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (S.C., A.-K.E.B.); Preventive Medicine and Cardiology Sections, Boston University School of Medicine and Department of Epidemiology, Boston University School of Public Health, MA (R.S.V.); Department of Clinical Sciences, Unit of Pediatrics (M.D.) and Department of Public Health and Clinical Medicine, Research Unit Skellefteå (J.H.J.), Umeå University, Sweden; and Department of Women's Children's Health, Karolinska Institutet, Stockholm, Sweden (A.-K.E.B.).
    Pregnancy characteristics are associated with risk of cardiovascular diseases, but their independent associations with hypertension or blood pressure (BP) levels remain uncertain. We linked the Swedish Medical Birth Register with Västerbotten Intervention Program data (Northern Sweden). Using linear and logistic regression, we related pregnancy factors in any prior pregnancy with BP and hypertension at 40 years of age in 15 896 parous women free of prepregnancy hypertension. Read More

    Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women.
    J Diabetes Res 2017 4;2017:4612623. Epub 2017 Jan 4.
    Ce.S.I-Met, "G. d'Annunzio" University, Chieti-Pescara, Via Colle dell'Ara No. 1, 66100 Chieti, Italy; Department of Medicine and Aging, School of Medicine and Health Sciences, "G. d'Annunzio" University, Chieti-Pescara, Chieti, Italy.
    Gestational diabetes mellitus (GDM) is the most frequent metabolic disorder in pregnancy. Women with a GDM history are at increased risk of developing diabetes and cardiovascular diseases. Studies have demonstrated a significant correlation between several genes involved in the metabolic pathway of insulin and environmental factors. Read More

    The temporal trend of vascular function in women with gestational diabetes.
    Vasc Med 2017 Jan 1:1358863X16678479. Epub 2017 Jan 1.
    2 Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
    The objective of the study was to assess the temporal changes in vascular function during pregnancy in healthy women and in those with gestational diabetes mellitus (GDM). Assessment of vascular function was done at three time points, 11-13(+6) weeks(+days), 20-22(+6) weeks(+days) and 30-32(+6) weeks(+days), by flow-mediated dilatation (FMD), augmentation index (AIx) and carotid-radial pulse wave velocity (crPWV) in women ( n=100) with singleton pregnancies. Out of the 100 women, 20 developed GDM, who were compared with 20 healthy, age-matched pregnant women in a nested case-control design. Read More

    Investigation of the vitamin D nutritional status in women with gestational diabetes mellitus in Beijing.
    Lipids Health Dis 2017 Jan 28;16(1):22. Epub 2017 Jan 28.
    Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
    Background: Vitamin D deficiency is a common issue, which has relation with GDM, during the pregnant period. To study the Vitamin D nutritional status of pregnant women with gestational diabetes mellitus (GDM) in the middle and late pregnancy and analyze the different sources of Vitamin D intake.

    Methods: A total of ninety-eight pregnant women with GDM were enrolled voluntarily in this study. Read More

    Higher maternal serum prolactin levels are associated with reduced glucose tolerance during pregnancy.
    J Diabetes Investig 2017 Jan 27. Epub 2017 Jan 27.
    Department of Endocrinology, Austin Health, Melbourne.
    It is unknown if high prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-hour glucose level from an oral glucose tolerance test (OGTT) in pregnancy. 75 gram OGTT was performed at 28 weeks of gestation in 69 participants. Read More

    Pregnancy and neonatal outcomes in women with type 1 diabetes mellitus.
    Bratisl Lek Listy 2017 ;118(1):56-60
    Aim: The aim of study was to compare some perinatal outcomes in mothers with type 1 diabetes mellitus (T1DM).

    Material And Methods: All patients with T1DM delivered at the 1st Department of Obstetrics and Gynaecology of Faculty of Medicine, Comenius University in Bratislava from January 1st 2009 to December 31th 2015 were included to the study.

    Results: Out of 118 diabetic mothers, 46. Read More

    Decidual arteriolopathy with or without associated hypertension modifies the underlying histomorphology in placentas from diabetic mothers.
    J Obstet Gynaecol Res 2017 Jan 27. Epub 2017 Jan 27.
    Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
    Aim: The aim of this study was to retrospectively document the impact of hypertensive conditions in pregnancy and decidual arteriolopathy on the patterns of placental injury in maternal diabetes mellitus (MDM).

    Methods: Among all 5248 > 20 weeks' placentas, the frequencies of 19 selected clinical and 24 placental phenotypes were compared between 287 MDM placentas and 4961 remaining placentas (control group [CG]) before and after further exclusion of 85 and 611 patients with hypertensive conditions (gestational hypertension, pre-eclampsia, chronic hypertension).

    Results: Cesarean section rate, heavy placentas, decidual arteriolopathy, microscopic chorionic pseudocysts, and chorangiosis were more common in MDM than in the CG both before and after exclusion of hypertensive conditions. Read More

    The emerging role of Metformin in Gestational Diabetes Mellitus.
    Diabetes Obes Metab 2017 Jan 27. Epub 2017 Jan 27.
    School of Pharmacy, The University of Queensland, Woolloongabba, QLD 4102, Australia.
    Metformin use during pregnancy is controversial and there is disparity in the acceptance of metformin treatment in women with gestational diabetes mellitus (GDM) in Australia. Despite short term maternal and neonatal safety, the placental transfer of metformin during GDM treatment and absence of long term safety data in offspring has regulators and prescribers cautious about its use. To determine the current role in GDM management, this literature review describes the physiological changes that occur in GDM and other forms of diabetes in pregnancy (DIP), and international changes in guidelines for GDM diagnosis. Read More

    Maternal and neonatal outcomes in Korean women with type 2 diabetes.
    Korean J Intern Med 2017 Jan 26. Epub 2017 Jan 26.
    Division of Endocrinology and Metabolism, Department of Medicine, Cheil General Hospital & Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea.
    Background/aims: The purpose of this study was to compare maternal and neonatal outcomes in Korean women with type 2 diabetes and nondiabetic controls.

    Methods: We performed a retrospective survey of 200 pregnancies in women with type 2 diabetes (n = 100) and nondiabetic controls (n = 100) who delivered from 2003 to 2010 at Cheil General Hospital & Women's Healthcare Center, Korea. We compared maternal characteristics as well as maternal and neonatal outcomes between groups matched by age, pre-pregnancy weight, body mass index, parity, and gestational age at delivery. Read More

    Association between Particulate Matter 2.5 and Diabetes Mellitus- a Meta-Analysis of Cohort Studies.
    J Diabetes Investig 2017 Jan 25. Epub 2017 Jan 25.
    Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
    Aims/introduction: This Meta-analysis was conducted to assess the association between exposure to the level of atmospheric particulate matter 2.5 (PM2.5, fine particulate matter with aerodynamic diameter less than 2. Read More

    Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes.
    Cochrane Database Syst Rev 2017 Jan 25;1:CD011967. Epub 2017 Jan 25.
    Liggins Institute, The University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.
    Background: Gestational diabetes mellitus (GDM) is a major public health issue with rates increasing globally. Gestational diabetes, glucose intolerance first recognised during pregnancy, usually resolves after birth and is associated with short- and long-term complications for the mother and her infant. Treatment options can include oral anti-diabetic pharmacological therapies. Read More

    Pre-pregnancy Obesity as a Modifier of Gestational Diabetes and Birth Defects Associations: A Systematic Review.
    Matern Child Health J 2017 Jan 24. Epub 2017 Jan 24.
    University of Maryland School of Medicine, 655 W. Baltimore Street, Room 14-029, Baltimore, MD, 21201-1559, USA.
    Objective Inconsistent findings of associations between gestational diabetes mellitus (GDM) and birth defects suggest unaccounted confounders may underlie the actual basis for such associations. We conducted a systematic review to assess observed associations between GDM and birth defects and the extent to which these could be explained by pre-pregnancy obesity. Methods Using a combination of search terms for GDM and birth defects, we searched PubMed, Scopus, CINAHL, and ClinicalTrials. Read More

    Review: Alterations in placental glycogen deposition in complicated pregnancies: Current preclinical and clinical evidence.
    Placenta 2017 Jan 11. Epub 2017 Jan 11.
    School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, 4072, Australia; Mater Medical Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD, 4101, Australia.
    Normal placental function is essential for optimal fetal growth. Transport of glucose from mother to fetus is critical for fetal nutrient demands and can be stored in the placenta as glycogen. However, the function of this glycogen deposition remains a matter of debate: It could be a source of fuel for the placenta itself or a storage reservoir for later use by the fetus in times of need. Read More

    Review: Placental derived biomarkers of pregnancy disorders.
    Placenta 2017 Jan 16. Epub 2017 Jan 16.
    School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
    Pregnancy is one of the greatest physiological challenges that a women can experience. The physiological adaptations that accompany pregnancy may increase the risk of developing a number of disorders that can lead to both acute and chronic physiological outcomes. In addition, fetal development may be impaired and, if the fetus survives, the child may be at an increased risk of disease throughout life. Read More

    Microvascular function in women with former gestational diabetes: A cohort study.
    Diab Vasc Dis Res 2017 Jan 1:1479164116683148. Epub 2017 Jan 1.
    1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
    Objective: In the long term, diabetes mellitus is potentially associated with the occurrence of microvascular damage. This study sought to assess whether a history of prior gestational diabetes mellitus is associated with long-term effects on the women's microcirculation.

    Methods: Within the scope of a long-term follow-up of the 'Viennese Post-Gestational Diabetes Project', women with prior gestational diabetes mellitus as well as women with previous pregnancy but with no history of gestational diabetes mellitus (controls) were enrolled in this cross-sectional study. Read More

    Role of Exosomes in Placental Homeostasis and Pregnancy Disorders.
    Prog Mol Biol Transl Sci 2017 16;145:163-179. Epub 2017 Jan 16.
    Exosome Biology Laboratory, Centre for Clinical Diagnostics, UQ Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, QLD, Australia; Ochsner Baptist Hospital, New Orleans, LA, United States.
    The human placenta is a unique organ that performs the function of the majority of fetal organs across gestation. How the placenta communicates with maternal tissues to prepare them for pregnancy is not fully understood. Recently, it has been established that placental cells can communicate with maternal tissues to regulate their biological function via extracellular vesicles (EVs). Read More

    Predictors of caesarean section - a cross-sectional study in Hungary.
    J Matern Fetal Neonatal Med 2017 Jan 23:1-18. Epub 2017 Jan 23.
    a Department of Obstetrics and Gynaecology , University of Szeged , Hungary.
    Purpose: The aim of this study was to analyse the factors associated with caesarean section (CS) at the Department of Obstetrics and Gynaecology, University of Szeged, Hungary.

    Study Design: Data collection was based on self-administered questionnaire and medical records related to the deliveries in the year of 2014. Maternal age, education level, marital status, pre-gestational body mass index (BMI), infertility treatment, previous CS, gestational diabetes mellitus (GDM), pre-pregnancy hypertension and pregnancy induced hypertension (HT/PIH) were examined. Read More

    Low rates of predominant breastfeeding in hospital after gestational diabetes, particularly among Indigenous women in Australia.
    Aust N Z J Public Health 2017 Jan 22. Epub 2017 Jan 22.
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria.
    Objectives: To investigate rates of 'any' and 'predominant' breastfeeding in hospital among Indigenous and non-Indigenous women with and without gestational diabetes mellitus (GDM).

    Methods: A retrospective study of singleton infants born from July 2007 to December 2010 at Cairns Hospital, Australia, following GDM pregnancy, using linked hospital and birth data (n=617 infants), with a subsample of medical record reviews (n=365 infants). Aggregate data were used to compare to breastfeeding rates among infants born following non-GDM pregnancy (n=7,894 infants). Read More

    Role of Insulin in Placental Transport of Nutrients in Gestational Diabetes Mellitus.
    Ann Nutr Metab 2017 Jan 21;70(1):16-25. Epub 2017 Jan 21.
    Department of Physiology, Molecular Biology B and Immunology, Murcia Biohealth Research Institute-University of Murcia (IMIB-UMU), Regional Campus of International Excellence "Campus Mare Nostrum," Murcia, Spain.
    Background: Gestational diabetes mellitus (GDM) is associated with increased fetal adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin receptors and maternal insulin can activate its signaling pathways, affecting the transport of nutrients to the fetus. However, the effects of diet or insulin treatment on the placental pathophysiology of GDM are unknown. Read More

    Pre-pregnancy weight change and incidence of gestational diabetes mellitus: A finding from a prospective cohort study.
    Diabetes Res Clin Pract 2017 Feb 11;124:72-80. Epub 2017 Jan 11.
    Centre for Longitudinal and Life Course Research, School of Public Health, The University of Queensland, Australia.
    Aims: In a population-based cohort study we examined the associations between early adult pre-pregnancy weight change and the risk of gestational diabetes mellitus (GDM).

    Methods: The study included 3111 women from the 1973-78 cohort of the Australian Longitudinal Study on Women's Health. These women have been surveyed regularly since 1996. Read More

    Gestational Diabetes Mellitus (GDM): Relationship Between Higher Cutoff Values for 100 g Oral Glucose Tolerance Test (OGTT) and Insulin Requirement During Pregnancy.
    Matern Child Health J 2017 Jan 19. Epub 2017 Jan 19.
    Endocrinology and Nutrition Department, Hospital Universitario Central de Asturias España, Asturias, Spain.
    Objectives To study if there is any relationship about higher cutoff values for 100 g oral glucose tolerance test and the need for insulin in women diagnosed with gestational diabetes. Materials and Methods This is a retrospective population-based study of 201 women diagnosed with Gestational Diabetes Mellitus (GDM) between January 2012 and June 2014 in the area of Oviedo, Asturias, Spain. According to diagnostic criteria recommended by GEDE, NDDG, gestational diabetes is diagnosed if two or more plasma glucose levels meet or exceed the following threshold: fasting glucose of 105 mg/dl, 1-h 190 mg/dl, 2-h 165 mg/dl, or 3-h 145 mg/dl. Read More

    Seasonal Pattern in the Diagnosis of Gestational Diabetes Mellitus in Southern Sweden.
    J Diabetes Res 2016 26;2016:8905474. Epub 2016 Dec 26.
    Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Endocrinology, Skåne University Hospital, Malmö, Sweden.
    Aim. The aim of this study was to examine seasonal patterns in glucose tolerance and in the diagnosis of gestational diabetes mellitus (GDM). Methods. Read More

    Racial and Ethnic Differences in the Polycystic Ovary Syndrome (PCOS) Metabolic Phenotype.
    Am J Obstet Gynecol 2017 Jan 16. Epub 2017 Jan 16.
    Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO.
    Background: Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome amongst women with polycystic ovarian syndrome is important for prevention strategies. Read More

    Gestational diabetes mellitus and retinal microvasculature.
    BMC Ophthalmol 2017 Jan 18;17(1). Epub 2017 Jan 18.
    Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore, 168751, Singapore.
    Background: Small-vessel dysfunction may be an important consequence of chronic hyperglycemia. We examined the association between gestational diabetes mellitus (GDM), a state of transient hyperglycemia during pregnancy, and retinal microvascular changes in pregnant women at 26-28 weeks of pregnancy.

    Methods: A total of 1136 pregnant women with singleton pregnancies were recruited during their first trimester at two major Singapore maternity hospitals in an on-going birth cohort study. Read More

    Impact of the Implementation of New WHO Diagnostic Criteria for Gestational Diabetes Mellitus on Prevalence and Perinatal Outcomes: A Population-Based Study.
    J Pregnancy 2016 21;2016:2670912. Epub 2016 Dec 21.
    Department of Obstetrics and Gynecology, University Hospital Merkur, Zajčeva 19, 10 000 Zagreb, Croatia; Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.
    Objectives. To determine the impact of the implementation of new WHO diagnostic criteria for gestational diabetes mellitus (GDM) on prevalence, predictors, and perinatal outcomes in Croatian population. Methods. Read More

    "It's a Very Big Burden on Me": Women's Experiences Using Insulin for Gestational Diabetes.
    Matern Child Health J 2017 Jan 13. Epub 2017 Jan 13.
    Group Health Research Institute, 1730 Minor Avenue, Suite 1280, Seattle, WA, USA.
    Objectives Gestational Diabetes Mellitus (GDM) affects hundreds of thousands of women each year. Many require medications to manage their blood glucose levels. Only insulin is approved by the U. Read More

    1 OF 427