BMC Pregnancy Childbirth 2017 May 26;17(1):154. Epub 2017 May 26.

Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: Excessive maternal pre-pregnancy and gestational weight gain are related to pregnancy- and birth outcomes. The interpregnancy time window offers a unique opportunity to intervene in order to acquire a healthy lifestyle before the start of a new pregnancy.

Methods: INTER-ACT is an e-health driven multicentre randomised controlled intervention trial targeting women at high risk of pregnancy- and birth related complications. Read More

Diabetes Metab Res Rev 2017 May 19. Epub 2017 May 19.

Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY.

Women with a history of gestational diabetes (GDM) are at high risk for developing type 2 diabetes mellitus (T2DM). In studies with long periods of follow up, diabetes incidence of up to 70% has been reported. The appropriate follow up of women following a pregnancy complicated by GDM has not been studied. Read More

PLoS One 2017 25;12(5):e0178528. Epub 2017 May 25.

Unit for Social Epidemiology, Faculty of Medicine, Lund University, Malmö, Sweden.

Background: Preeclampsia (PE) is associated with a high risk of perinatal morbidity and mortality. However, there is no consensus in the definition of high-risk women.

Aim: To question current definition of high PE risk and propose a definition that considers individual heterogeneity to improves risk classification. Read More

PLoS One 2017 22;12(5):e0178150. Epub 2017 May 22.

Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.

Preeclampsia and gestational diabetes (GDM) have several mechanisms in common. The aim of this study was to determine whether women with preeclampsia have an increased risk of GDM in a subsequent pregnancy. Study data were collected from the Korea National Health Insurance Claims Database of the Health Insurance Review and Assessment Service for 2007-2012. Read More

PLoS One 2017 23;12(5):e0178100. Epub 2017 May 23.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Although thyroid dysfunction in early pregnancy may have adverse effects on pregnancy outcomes, few studies have examined the relationship between maternal low free thyroxin (FT4) levels in both first and third trimesters of pregnancy and the incidence of adverse pregnancy outcomes. We hypothesized that low FT4 levels in either first or third trimesters of pregnancy may have different effects on pregnancy outcomes. The study included 6,031 mothers who provided both first and third pregnancy serum samples for analyses of thyroid function. Read More

Scand J Clin Lab Invest 2017 May 24:1-6. Epub 2017 May 24.

a Department for Congenital Disorders , Statens Serum Institut , Copenhagen , Denmark.

Risk stratification and patient management in heart failure (HF) is difficult due to the unpredictable progression of the disease, necessitating the development of reliable diagnostic biomarkers to facilitate decision-making in clinical practice. Pregnancy-associated plasma protein-A (PAPP-A) is a marker of arteriosclerotic heart disease. PAPP-A is a serum protease, which is involved in the insulin-like growth factor 1 (IGF-1) axis where it is inhibited by the proform of the eosinophil major basic protein (proMBP). Read More

Am J Epidemiol 2017 May 23. Epub 2017 May 23.

Chain event graphs are a graphical representation of a statistical model derived from event trees, previously applied to cohort studies but not to case-control studies. We apply the chain event graph framework to a Yorkshire case-control study of childhood type I diabetes, to examine four exposure variables associated with the mother, three of which are fully observed (her school-leaving-age, amniocenteses during pregnancy and delivery type) and one with missing values (her rhesus factor), while incorporating previous type I diabetes knowledge. We conclude that the unknown rhesus factor values are likely to be missing not at random, and are mainly rhesus positive. Read More

Obstet Gynecol Sci 2017 May 15;60(3):274-282. Epub 2017 May 15.

Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon, Korea.

Objective: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first detected during pregnancy. It can result in pregnancy complications such as birth injury, stillbirth. Fatty acid-binding protein 4 (FABP4), found in adipose tissue, is associated with insulin resistance, and type 2 diabetes. Read More

Diabetes Metab Syndr 2017 May 10. Epub 2017 May 10.

Nutrition Program, School of Dentistry and Health Sciences, Charles Sturt University, Wagga Wagga, Australia. Electronic address:

Aims: This review examined whether maternal and paternal periconceptional nutrition effects an offspring's likelihood of developing chronic metabolic related conditions due to epigenetic imprinting.

Methods: A literature search was conducted in multiple science databases and limited to studies published after 2012, in English language and peer reviewed. The data from selected articles were extracted and a qualitative approach was employed due to heterogeneity of results. Read More

Diabetes Res Clin Pract 2017 Apr 25;129:148-153. Epub 2017 Apr 25.

Diabetes and Endocrine Service, Liverpool Hospital, Australia.

Aims: In this study, we assessed changes in prevalence of gestational diabetes mellitus (GDM) in a region with diverse cultural backgrounds in Australia under the new World Health Organization (WHO) diagnostic criteria, with reference to the woman's ethnicity, age and pre-pregnant body mass index (BMI).

Methods: We recorded results of all 75-gram oral glucose tolerance tests (OGTTs) performed on pregnant women between February and December 2015 together with their demographic details, and determined the prevalence of GDM based on the old Australian Diabetes in Pregnancy Society (ADIPS) and the new WHO criteria respectively.

Results: Over that period, 2140 OGTTs were performed in 1725 pregnant women. Read More

Diabetes Res Clin Pract 2017 May 5;129:105-115. Epub 2017 May 5.

Royal Darwin Hospital, Darwin, Australia; Menzies School of Health Research, Darwin, Australia. Electronic address:

Aims: Preconception care may decrease adverse pregnancy outcomes associated with pre-existing diabetes mellitus. Aboriginal Australians are at high risk of type 2 diabetes mellitus (T2DM), with earlier onset. We explored practitioner views on preconception care delivery for women with T2DM in the Northern Territory, where 31% of births are to Aboriginal women. Read More

Arch Gynecol Obstet 2017 May 16. Epub 2017 May 16.

Department of Gynecology and Obstetrics, Herning Hospital, Gl. Landevej 61, 7400, Herning, Denmark.

Purpose: The cornerstone in treatment of gestational diabetes mellitus (GDM) is medical nutrition therapy (MNT), but the effect on birth weight is disputed. The birth weight was evaluated with respect to length of MNT and adherence to diet.

Methods: We performed a cohort study on 436 women with GDM and 254 non-diabetic women. Read More

Ultrasound Obstet Gynecol 2017 May 15. Epub 2017 May 15.

Harris Birthright Research Centre for Fetal Medicine, King's College, London, UK.

Objective: A survival-time regression model for the gestational age at delivery with preeclampsia (PE) in singleton pregnancies using maternal demographic characteristics and medical history was previously reported. The objective of this paper is to extend this model for dichorionic (DC) and monochorionic (MC) twin pregnancies.

Methods: The study population included 1,789 DC and 430 MC twin pregnancies and 93,297 singleton pregnancies. Read More

Diabetol Metab Syndr 2017 12;9:32. Epub 2017 May 12.

Endocrine Research Unit, National Medical Center, IMSS, Cuauhtemoc 330, 06720 Mexico City, Mexico.

Background: Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared with healthy pregnant controls. Read More

CMAJ 2017 May;189(19):E682-E689

Departments of Medicine (Booth, Ray) and Obstetrics and Gynecology (Ray), St. Michael's Hospital; Institute for Clinical Evaluative Sciences (Booth, Luo, Park, Feig, Moineddin, Ray); Department of Medicine (Feig), Mount Sinai Hospital; Department of Family and Community Medicine (Moineddin), and Department of Medicine (Booth, Feig, Ray), University of Toronto, Toronto, Ont.

Background: Cold-induced thermogenesis is known to improve insulin sensitivity, which may become increasingly relevant in the face of global warming. The aim of this study was to examine the relation between outdoor air temperature and the risk of gestational diabetes mellitus.

Methods: We identified all births in the Greater Toronto Area from 2002 to 2014 using administrative health databases. Read More

Can J Diabetes 2017 May 12. Epub 2017 May 12.

Canadian Vigour Centre, University of Alberta, Edmonton, Alberta, Canada; School of Public Health, University of Alberta, Edmonton, Alberta, Canada; Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Objectives: We assessed the rate and type of postpartum glycemic testing in women with impaired glucose tolerance of pregnancy (IGTp) and gestational diabetes mellitus (GDM). We examined whether the likelihood of testing was modulated by patients' characteristics and pregnancy outcomes.

Methods: Our population-level cohort study included data from 132,905 pregnancies between October 1, 2008, and December 31, 2011, in Alberta, Canada. Read More

Clin Nutr Res 2017 Apr 25;6(2):81-88. Epub 2017 Apr 25.

Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.

Gestational diabetes mellitus (GDM) is described as glucose intolerance diagnosed during pregnancy. Increased oxidative stress has implicated in diabetic problems. The aim of the current study was to compare antioxidant capacity and antioxidant nutrient intake between women with GDM (n = 40) and healthy pregnant women (n = 40). Read More

Clin Epigenetics 2017 8;9:49. Epub 2017 May 8.

Institute of Behavioral Sciences, University of Helsinki, Helsinki, 00014 Finland.

Background: A recent study has shown that it is possible to accurately estimate gestational age (GA) at birth from the DNA methylation (DNAm) of fetal umbilical cord blood/newborn blood spots. This DNAm GA predictor may provide additional information relevant to developmental stage. In 814 mother-neonate pairs, we evaluated the associations between DNAm GA and a number of maternal and offspring characteristics. Read More

Am J Obstet Gynecol 2017 May 11. Epub 2017 May 11.

Nutrition and Diabetology Department, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.

Reprod Toxicol 2017 May 10;71:118-123. Epub 2017 May 10.

Department of Paediatrics, Subdivision of Endocrinology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands.

Glucocorticoids are given during pregnancy when rheumatoid arthritis (RA) is too active. It could lead to increased risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) in the offspring. Elevated RA disease activity during pregnancy is associated with low birth weight and rapid post-natal growth. Read More

J Renal Inj Prev 2017 25;6(2):137-141. Epub 2016 Dec 25.

Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Restless leg syndrome (RLS) is a sensory motor disorder. Patients with this syndrome have serious and uncontrollable desire to move their legs, which is mostly due to an uncomfortable feeling intensified when they are motionless. It may be a genetic disorder or secondary to iron deficiency, neurodegenerations, pregnancy, some drugs and severe kidney diseases. Read More

Eur J Obstet Gynecol Reprod Biol 2017 May 3;214:91-96. Epub 2017 May 3.

Department of Obstetrics and Gynaecology, Groote Schuur Hospital, Cape Town, 7937, South Africa.

Background: In contrast to sporadic miscarriage, recurrent miscarriage (RM) is a rare entity which affects 1% of couples attempting conception. It is distressing for couples and healthcare professionals as the aetiology is unclear with limited treatment options. Apart from anti-phospholipid syndrome (APS), the strength of associations between RM and commonly investigated endocrine, autoimmune, thrombophilic and uterine structural abnormalities remains uncertain and variable. Read More

Int J Gynaecol Obstet 2017 May 11. Epub 2017 May 11.

Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey.

Objective: To determine the prevalence of gestational diabetes mellitus (GDM) and its association with maternal age among Turkish women diagnosed by International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria.

Methods: A cross-sectional study was conducted in 2013-2015 among non-diabetic pregnant women aged 18-49 years who were universally screened for GDM by IADPSG criteria. The percentage of women meeting each diagnostic threshold and the prevalence of GDM by age group were calculated. Read More

J Coll Physicians Surg Pak 2017 Apr;27(4):203-208

Department of Obstetrics and Gynecology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.

Objective: To compare the status of female sexual dysfunction (FSD) between women with a history of previous gestational diabetes mellitus (GDM) and those with follow-up of a healthy pregnancy, using the female sexual function index (FSFI) questionnaire.

Study Design: Cross-sectional study.

Place And Duration Of Study: Department of Obstetrics and Gynecology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey, from September to December 2015. Read More

Case Rep Obstet Gynecol 2017 11;2017:6061313. Epub 2017 Apr 11.

Department of Obstetrics & Gynecology, University of New Mexico, Albuquerque, NM, USA.

Background. Hyperparathyroidism is underdiagnosed in pregnancy, yet early diagnosis is necessary for the potentially severe sequelae of hypercalcemia for both the woman and fetus. Case. Read More

Epigenetics 2017 May 9. Epub 2017 May 9.

a Department of Biochemistry , Université de Sherbrooke , Sherbrooke , QC , Canada.

Gestational diabetes mellitus (GDM) is associated with obesity in childhood. This suggests that consequences of in utero exposure to maternal hyperglycemia extend beyond the fetal development, possibly through epigenetic programming. The aims of this study were to assess whether placental DNA methylation (DNAm) marks were associated with maternal GDM status and to offspring body composition at 5 years old in a prospective birth cohort. Read More

Am J Epidemiol 2017 May 6. Epub 2017 May 6.

Previous studies have found associations between individual healthy behaviors and reduced risk of gestational diabetes mellitus (GDM); however, the association of composite healthy lifestyle during pregnancy with GDM has not been examined. Participants (n = 3,005) in the Omega study, a pregnancy cohort in Washington State (1996-2008), reported diet, physical activity, smoking, and stress during early pregnancy. Lifestyle components were dichotomized into healthy/unhealthy, then combined into a total lifestyle score (0-4). Read More

Reprod Sci 2017 Jan 1:1933719117707055. Epub 2017 Jan 1.

1 Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany.

The incidence of diabetes mellitus for young people rises since years. A preconceptional diabetes mellitus leads to subfertility. Most of the causes for a diabetic subfertility are still unknown. Read More

Sex Reprod Healthc 2017 Jun 22;12:16-23. Epub 2016 Nov 22.

The University of Texas at El Paso, College of Health Sciences, Department of Public Health Sciences, 500 W University Ave, El Paso, TX 79902, United States. Electronic address:

Aim: The aim of this study was to explore the experiences of Hispanic women of Mexican origin with gestational diabetes mellitus (GDM).

Background: GDM is associated with poorer maternal and infant outcomes. Rates of GDM occur at higher rates among Hispanic women of Mexican origin compared to non-Hispanic White women. Read More

Mutat Res 2017 Jun 13;818:27-30. Epub 2017 Apr 13.

Department of Biology and Medical Genetics, Medical University of Lodz, Haller's Square 1, 90-647 Lodz, Poland. Electronic address:

Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance which results in hyperglycemia first diagnosed during pregnancy. It is associated with an increased levels of oxidative stress due to overproduction of reactive oxygen species (ROS). Overproduction of ROS induces protein oxidation, lipid peroxidation and different types of DNA damage. Read More

Ir J Med Sci 2017 May 5. Epub 2017 May 5.

UCD Obstetrics and Gynaecology, School of Medicine, National Maternity Hospital, University College Dublin, Holles Street, Dublin 2, Ireland.

Background: Gestational diabetes mellitus (GDM) is identified in pregnancy and resolves following delivery. It increases maternal and foetal morbidity and may increase risk of future type 2 diabetes. Women diagnosed with GDM need high-quality multidisciplinary education in order to apply necessary changes to their diet and lifestyle. Read More

Nutrients 2017 May 5;9(5). Epub 2017 May 5.

Be Active Sleep & Eat (BASE) Facility, Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC 3168, Australia.

The metabolic effects of probiotic administration in women with gestational diabetes mellitus (GDM) is unknown. The objective of this review was to investigate the effect of probiotics on fasting plasma glucose (FPG), insulin resistance (HOMA-IR) and LDL-cholesterol levels in pregnant women diagnosed with GDM. Seven electronic databases were searched for RCTs published in English between 2001 and 2017 investigating the metabolic effects of a 6-8 week dietary probiotic intervention in pregnant women following diagnosis with GDM. Read More

Hum Reprod 2017 May 4:1-11. Epub 2017 May 4.

Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Halle (Saale), Germany.

Study Question: How does a maternal diabetic hyperadiponectineamia affect signal transduction and lipid metabolism in rabbit preimplantation blastocysts?

Summary Answer: In a diabetic pregnancy increased levels of adiponectin led to a switch in embryonic metabolism towards a fatty acid-dependent energy metabolism, mainly affecting genes that are responsible for fatty acid uptake and turnover.

What Is Known Already: Although studies in cell culture experiments have shown that adiponectin is able to regulate lipid metabolism via 5'-AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor α (PPARα), data on the effects of adiponectin on embryonic lipid metabolism are not available. In a diabetic pregnancy in rabbits, maternal adiponectin levels are elevated fourfold and are accompanied by an increase in intracellular lipid droplets in blastocysts, implying consequences for the embryonic hormonal and metabolic environment. Read More

Chin Med J (Engl) 2017 May;130(9):1019-1025

World Diabetes Foundation, Gentofte 2820, Denmark.

Background: Gestational diabetes mellitus (GDM) is associated with both short- and long-term adverse health consequences for both the mother and her offspring. The aim was to study the prevalence and risk factors for GDM in Beijing.

Methods: The study population consisted of 15,194 pregnant women attending prenatal care in 15 hospitals in Beijing, who delivered between June 20, 2013, and November 30, 2013, after 28 weeks of gestation. Read More

Chin Med J (Engl) 2017 May;130(9):1012-1018

Helen Schneider Hospital for Women, Rabin Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Petah-Tiqva, Tel-Aviv 6997801, Israel.

Background: Hyperglycemia is associated with adverse pregnancy outcomes. However, the relationships between them remain ambiguous. This study aimed to analyze the effect of different oral glucose tolerance test (OGTT) results on adverse perinatal outcomes. Read More

BMC Res Notes 2017 May 2;10(1):174. Epub 2017 May 2.

Department Obstetrics and Gynaecology, St. Francis Hospital Nsambya, P.O.Box 7146, Kampala, Uganda.

Background: Women with hyperglycaemia detected during pregnancy are at greater risk for adverse pregnancy outcomes. Data on hyperglycaemia in pregnancy in sub-Saharan Africa is scanty and varied depending on the populations studied and the methodologies used to define hyperglycaemia in pregnancy. With the recent 2013 World Health Organisation (WHO) diagnostic criteria and classification, there is yet no sufficient data on the prevalence of hyperglycaemia in sub-Saharan Africa. Read More

Curr Diabetes Rev 2017 May 1. Epub 2017 May 1.

Department of Obstetrics and Gynecology, Ain Shams University Hospital, Cairo. Egypt.

Background: Gestational diabetes mellitus is any degree of glucose intolerance with first diagnosis during pregnancy; it affects 3-10% of pregnancies. The presence of diabetes-related autoantibodies has shown to be able to predict the development of type 1 diabetes before hyperglycemia arises.

Objective: To recognize the prevalence of islet cell antibodies among a sample of Egyptian females with gestational diabetes and its possible relation to development of Type 1 diabetes within one year postpartum. Read More

Int J Reprod Biomed (Yazd) 2017 Feb;15(2):109-114

Islamic Azad University, South Tehran Branch, Tehran, Iran.

Background: The outbreak of gestational diabetes has a significant increase during recent years. This disease has complications for mother and her baby. Screening is an opportunity for preventing of gestational diabetes complications. Read More

J Clin Endocrinol Metab 2017 Apr 28. Epub 2017 Apr 28.

Research Institute of Internal Medicine.

Context: Fetuses exposed to an obese intrauterine environment are more likely to be born large-for-gestational age (LGA) and are at increased risk of obesity in childhood and cardiovascular disease (CVD) and/or type 2 diabetes mellitus (T2DM) as adults, but which factors that influence the intrauterine environment is less clear.

Objective: To investigate the association between circulating levels of leptin and adiponectin, measured multiple times during pregnancy, and birth weight and prevalence of LGA or small-for-gestational age (SGA) infants. The association between birth weight and mRNA expression of adiponectin receptors and genes involved in nutrient transport in the placenta was also investigated. Read More

Climacteric 2017 Jun 29;20(3):222-227. Epub 2017 Apr 29.

a Department of Reproductive Medicine and Gynecology , University Medical Center Utrecht , Utrecht , The Netherlands.

To date, the world's leading cause of death amongst women is cardiovascular disease. Polycystic ovary syndrome (PCOS) is associated with an unfavorable cardiometabolic profile in early life. Apart from dyslipidemia, obesity and onset of type 2 diabetes mellitus, androgens are thought to influence cardiovascular health. Read More

Am J Obstet Gynecol 2017 Apr 26. Epub 2017 Apr 26.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:

Gestational diabetes mellitus poses well-established risks to both the mother and infant. As >50% of women with gestational diabetes mellitus will develop type 2 diabetes mellitus in their lifetime, performing postpartum oral glucose tolerance testing is paramount to initiation of appropriate lifestyle interventions and pharmacologic therapy. Nonetheless, test completion among women with gestational diabetes mellitus is estimated to be <50%, with particularly low rates in Latina patients, as well as patients with public insurance, low education levels, and low health literacy. Read More

Can J Diabetes 2017 Apr 25. Epub 2017 Apr 25.

University of Alberta, Canadian Vigour Centre, Edmonton, Alberta, Canada; University of Alberta, School of Public Health, Edmonton, Alberta, Canada.

Objectives: To examine outcomes associated with alternative glucose thresholds in a 2-step approach for screening and diagnosing gestational diabetes mellitus (GDM).

Methods: We studied 178,527 pregnancies between 2008 and 2012 in Alberta, Canada. They were categorized retrospectively as normal 50 g screen (n=144,191); normal 75 g oral glucose tolerance test (OGTT) (n=21,248); abnormal at glucose thresholds suggested by the International Association of Diabetes and Pregnancy Group (IADPSG) (HAPO 1. Read More

Placenta 2017 Apr 1;52:94-99. Epub 2017 Mar 1.

Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Pathology & Laboratory Medicine, Women & Infants Hospital of Rhode Island, Providence, RI, USA; Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. Electronic address:

Introduction: Data on the correlation among Hemoglobin A1c (HbA1c), placental pathology, and perinatal outcome in the pregestational diabetic population is severely lacking. We believe that this knowledge will enhance the management of pregnancies complicated by pregestational diabetes. We hypothesize that placental pathology correlates with glycemic control at an early gestational age. Read More

Gynecol Endocrinol 2017 Apr 28:1-4. Epub 2017 Apr 28.

a Xiangyang Central hospital (The Affiliated Hospital of Hubei University of Arts and Science) , Xiangyang , China.

Objective: To investigate the association between chemerin level in the first trimester of pregnancy and the risk of gestational diabetes mellitus.

Methods: The blood samples of 212 women at 8-12 weeks of gestation were collected. After screening for gestational diabetes mellitus (GDM), 19 women with GDM and 20 women randomly selected from 144 women with normal glucose tolerance (NGT) were included in the study. Read More

Pan Afr Med J 2017 2;26:62. Epub 2017 Feb 2.

Medeniyet University School of Medicine, Department of Obstetrics and Gynecology, Turkey.

Introduction: There has been an increased incidence of macrosomic newborns in the world and most of the macrosomic newborns are born from non-GDM pregnant women. The objective of this study was to determine the frequency and the associated risk factors of fetal macrosomia in non-GDM pregnant women.

Methods: A total 4246 consequtive pregnant women who had no GDM was included the study population. Read More

Diabetes Care 2017 Apr 27. Epub 2017 Apr 27.

Division of Hematology, Brigham and Women's Hospital, Boston, MA

Objective: Plasma glycated CD59 (pGCD59) is an emerging biomarker in diabetes. We assessed whether pGCD59 could predict the following: the results of the glucose challenge test (GCT) for screening of gestational diabetes mellitus (GDM) (primary analysis); and the diagnosis of GDM and prevalence of large for gestational age (LGA) newborns (secondary analyses).

Research Design And Methods: Case-control study of 1,000 plasma samples from women receiving standard prenatal care, 500 women having a normal GCT (control subjects) and 500 women with a failed GCT and a subsequent oral glucose tolerance test (case patients). Read More

Ethiop J Health Sci 2016 Sep;26(5):409-414

Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, KSA.

Background: Gestational diabetes mellitus (GDM) is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the disease in the non-pregnant state but also helpful in preventing the occurrence of GDM. The aim of the study was to assess the effect of aerobic exercises on insulin sensitivity and fasting plasma glucose level in pregnant women with risk for gestational diabetes mellitus. Read More

Clin Diabetes 2017 Apr;35(2):84-89

Ohio University, Heritage College of Osteopathic Medicine, Athens, OH.

IN BRIEF Traditional methods of screening for and diagnosing gestational diabetes mellitus (GDM) have been challenged, leading to the development of new screening guidelines by the International Association of Diabetes and Pregnancy Study Groups (IADPSG). This study is a retrospective comparison of pregnancy outcomes based on the Carpenter and Coustan (CC) and IADPSG screening guidelines. It demonstrates that adoption of IADPSG guidelines increased the rate of GDM diagnosis and resulted in more women with diet-controlled GDM. Read More

Zhonghua Fu Chan Ke Za Zhi 2017 Apr;52(4):227-232

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

Objective: To analyze the characteristics of pre-gestational diabetes mellitus (PGDM) diagnosed during pregnancy (missed diagnosis before pregnancy), and to evaluate the effects of diagnostic time on pregnancy outcomes. Methods: A retrospective study of 746 pregnant women who were diagnosed PGDM and delivered in Peking University First Hospital from January 1st, 2005 to December 31st, 2015 was conducted. The patients were divided into 2 group. Read More