Metabolism 2017 Aug 24. Epub 2017 Aug 24.

Division of Obstetrics & Gynaecology, School of Medicine, Faculty of Health and Medical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia. Electronic address:

Background: Cytokines produced by adipose and placental tissues (adipokines) have been implicated in the development of gestational diabetes mellitus (GDM). There is, however, limited research regarding the relationship between advancing pregnancy, maternal adipokine profile, insulin resistance and the development of GDM. Furthermore, no studies have investigated these parameters in women with a history of GDM who are at the highest risk of recurrence. Read More

BMC Pregnancy Childbirth 2017 Sep 21;17(1):314. Epub 2017 Sep 21.

Department of Obstetrics and Gynaecology, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, 28029, Madrid, ES, Spain.

Background: In an era of worldwide population displacement, recent studies have identified strong associations between social situations and perinatal outcomes among immigrants. Little is known about the effect of maternal social background on pregnancy outcomes. The Human Development Index (HDI) assesses the following dimensions of human development: life expectancy, education level and income. Read More

Front Physiol 2017 6;8:675. Epub 2017 Sep 6.

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing, China.

Gestational diabetes mellitus (GDM) has significant implications for the future health of the mother and child. However, the associations between human placental microbiota and GDM are poorly understood. We aimed to profile the placental microbiota of GDM and further define whether or not certain placental microbiota taxon correlates with specific clinical characteristics. Read More

Orthop Nurs 2017 Sep/Oct;36(5):323-327

Catherine O. Durham, DNP, FNP-BC, Director, MSN DN Program, College of Nursing, Medical University of South Carolina, MSC 160, Charleston. Kathy VanRavenstein, PhD, FNP-BC, Instructor, Medical University of South Carolina, College of Nursing, Charleston.

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy accounting for 90% of similar disorders, occurring in 3.8% of the population, common in adults aged 40-60 years, and is associated with an average 32 lost days of work and lost productivity. In addition to occupational exposure, there are several common chronic disorders that can preclude CTS, obesity, diabetes mellitus, rheumatoid arthritis, pregnancy, metabolic syndrome, and thyroid disorder, to name a few. Read More

Medicine (Baltimore) 2017 Sep;96(38):e7939

Department of Epidemiology and Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.

Background: The safety and efficacy of different drugs in treatment of gestational diabetes mellitus (GDM) patients who could not maintain normal glucose level only through diet and exercise remains to be debated. We performed this network meta-analysis (NAM) to compare and rank different antidiabetic drugs in glucose level control and pregnancy outcomes in GDM patients.

Methods: We searched PubMed, Cochrane Library, Web of Science, and Embase up to December 31, 2016. Read More

PeerJ 2017 13;5:e3809. Epub 2017 Sep 13.

Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, United States of America.

Bisphenol A (BPA) is a synthetic unit of polycarbonate polymers and epoxy resins, the types of plastics that could be found in essentially every human population and incorporated into almost every aspect of the modern human society. BPA polymers appear in a wide range of products, from liquid storages (plastic bottles, can and glass linings, water pipes and tanks) and food storages (plastics wraps and containers), to medical and dental devices. BPA polymers could be hydrolyzed spontaneously or in a photo- or temperature-catalyzed process, providing widespread environmental distribution and chronic exposure to the BPA monomer in contemporary human populations. Read More

J Pregnancy 2017 27;2017:4935397. Epub 2017 Aug 27.

Department of Maternal Fetal Medicine, Pregnancy Research Centre, Royal Women's Hospital, 20 Flemington Road, Parkville, Melbourne, VIC, Australia.

Background: Current data on the rates of macrosomia in women with gestational diabetes mellitus (GDM) are heterogenous. No study has specifically examined macrosomia rates in women with diet-controlled gestational diabetes.

Aims: To compare the rates of macrosomia between mothers with diet-controlled GDM to mothers without diabetes mellitus. Read More

PLoS One 2017 19;12(9):e0184966. Epub 2017 Sep 19.

Department of Epidemiology, Harvard T. Chan School of Public Health, Boston, Massachusetts, United States of America.

Background: Obstructive sleep apnea (OSA) or habitual snoring is known to be associated with impaired glucose tolerance and type 2 diabetes among both men and non-pregnant women. We examined the association of habitual snoring during early pregnancy with risk of impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM).

Methods: A cohort of 1,579 women was interviewed during early pregnancy. Read More

Mymensingh Med J 2017 Jul;26(3):658-666

Dr Kaniz Fatema, Assistant Professor, Department of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

This study was done to find out the maternal risk factors associated with congenital anomaly. This cross-sectional observational study was carried out in the Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital, Dhaka, Bangladesh from January 2011 to December 2011. During this study period 78 patients had pregnancy with congenital anomaly and delivered in the Department of Obstetrics and Gynaecology. Read More

Diabetes Res Clin Pract 2017 Aug 30;133:85-91. Epub 2017 Aug 30.

Department of Medicine, Universitat Pompeu Fabra, Campus del Mar, Passeig Marítim, 25-29, 08003 Barcelona, Spain; Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Passeig Marítim, 25-29, 08003 Barcelona, Spain; Department of Gynecology and Obstetrics, Hospital del Mar, Passeig Marítim, 25-29, 08003 Barcelona, Spain.

Aims: To evaluate the usefulness and efficacy of first-trimester HbA1c in the diagnosis of gestational diabetes (GDM).

Methods: Prospective observational of consecutive pregnant women. All women had a first-trimester HbA1c determination and GDM screening at 24-28weeks of pregnancy using a two-step approach. Read More

Turk J Obstet Gynecol 2017 Jun 15;14(2):94-99. Epub 2017 Jun 15.

Başkent University Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and IVF, Adana, Turkey.

Objective: To evaluate the effects of percutaneous pigtail catheter drainage on the outcomes of intracytoplasmic sperm injection (ICSI) pregnancies following moderate or severe ovarian hyperstimulation syndrome (OHSS).

Materials And Methods: This retrospective study included 189 patients hospitalized for OHSS following ICSI treatment in a tertiary in vitro fertilization unit between 2006 and 2014. Pigtail catheters were applied in 63 patients; the other 126 patients did not need that treatment. Read More

Turk J Obstet Gynecol 2017 Mar 15;14(1):23-27. Epub 2017 Mar 15.

Zekai Tahir Burak Women's Health Training and Research Hospital, Clinic of Perinatology, Ankara, Turkey.

Objective: To evaluate the correlation between reversed a-wave in ductus venosus at 16-20 weeks' gestation and trisomy 21 and adverse perinatal outcomes.

Materials And Methods: Our study included 174 pregnant women who were under follow-up at a tertiary center between May and September 2010. Ductus venosus Doppler (DVD) measurements were obtained throughout the 6-month period from women who underwent amniocentesis procedures due to increased risk for trisomy 21 in terms of first or second trimester screening test results. Read More

Turk J Obstet Gynecol 2017 Mar 15;14(1):18-22. Epub 2017 Mar 15.

Selçuk University Faculty of Medicine, Department of Biochemistry, Konya, Turkey.

Objective: The two-step approach recommended by the National Diabetes Data Group (NDDG), Carpenter and Coustan (C&C), and O'Sullivan, and the single-step approach recommended by the International Association of Diabetes and Pregnancy Study Group (IADPSG) are used to diagnose gestational diabetes mellitus (GDM). We aimed to determine GDM prevalence and to compare the two-step and single-step approaches used in the southeastern region of Turkey.

Materials And Methods: In total, 3048 records of pregnant women screened for GDM between 2008 and 2014 were retrospectively extracted from our laboratory information system. Read More

J Diabetes Complications 2017 Aug 9. Epub 2017 Aug 9.

Institut national de santé publique du Québec, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

Aims: We assessed the long-term risk of cataract following a pregnancy complicated by gestational diabetes.

Methods: We carried out a longitudinal cohort study of 1,108,541 women who delivered infants between 1989-2013 in Quebec, Canada, with follow-up extending up to 25years later. The cohort included 71,862 women with gestational diabetes and 5247 with cataracts. Read More

Adv Biomed Res 2017 31;6:109. Epub 2017 Aug 31.

Department of Obstetrics and Gynecology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Magnesium (Mg) is an essential mineral required to regulate body temperature, nucleic acid, and protein synthesis with an important role in maintaining nerve and muscle cell electrical potentials. It may reduce fetal growth restriction and preeclampsia as well as increase birth weight. This study aimed to assess the effects of consuming Mg supplementation during pregnancy on pregnancy outcomes. Read More

Pan Afr Med J 2017 11;27:189. Epub 2017 Jul 11.

Laboratoire Biochimie, Biotechnologie, Santé et Environnement, Département de Biologie, Faculté des Sciences, Université Ibn Tofail, BP 133, Kénitra 14 000, Maroc.

Introduction: Diabetes is a disorder of assimilation, use and storage of sugars provided in the diet. Its management is based on follow-up of overweight and obese patients and on regular glycemic control. This study aimed to analyze overweight, obesity and glycemic control in 2227 patients with different types of diabetes (type 1, 2 and gestational) presenting to the Provincial referral center of diabetes (RCD) in Kenitra, Morocco. Read More

Pan Afr Med J 2017 29;27:148. Epub 2017 Jun 29.

Service d'Anesthésie-Réanimation du Centre Hospitalier Universitaire de Bouaké, Côte d'Ivoire.

Ketoacidosis complicating gestational diabetes is rare and responsible for severe maternal-fetal mortality. It is an acute metabolic emergency whose management is multidisciplinary. Early diagnosis and treatment affect the vital prognosis of both the mother and the fetus. Read More

Pan Afr Med J 2017 16;27:128. Epub 2017 Jun 16.

Department of Neonatology, University of Monastir, Tahar Sfar University Hospital, 5111 Mahdia, Tunisia.

The caudal regression syndrome is defined as total or partial agenesis of the sacrum and lumbar spine, frequently associated with other developmental malformations (orthopedic, neurological, genito-urinary, gastrointestinal…). Prenatal diagnosis is possible through fetal ultrasound (US) and magnetic resonance imaging (MRI). A case of fetal caudal regression syndrome with omphalocele from a diabetic mother is presented, demonstrating the sonographic, MRI, CT and X-Ray features diagnostic. Read More

Rev Recent Clin Trials 2017 Sep 11. Epub 2017 Sep 11.

University of Maryland School of Medicine Department of Internal Medicine, Division of Endocrinology, Diabetes, and Nutrition 827 Linden Avenue Baltimore, MD 21201. United States.

Background: Women with gestational diabetes mellitus (GDM) are at an increased risk for developing metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. In this review, we will discuss postpartum cardiovascular and diabetes risk in women with a history of GDM and different ways to improve postpartum screening.

Methods: This review involves a comprehensive literature review on gestational diabetes and post-partum risk for cardiovascular disease and diabetes mellitus as well as post-partum screening methods. Read More

Aust N Z J Obstet Gynaecol 2017 Sep 13. Epub 2017 Sep 13.

School of Medicine, University of Notre Dame Australia, Fremantle, Western Australia, Australia.

Background: Rates of pre-gestational obesity and gestational diabetes mellitus (GDM) are increasing in Australia. While both are established risk factors for neonatal hypoglycaemia, the additive effect of both risks on neonatal hypoglycaemia is not well understood.

Aims: To determine the influence of obesity on neonatal hypoglycaemia among infants born to GDM mothers. Read More

BMC Pregnancy Childbirth 2017 Sep 12;17(1):302. Epub 2017 Sep 12.

Department of Anesthesiology, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.

Background: During pregnancy, the hyperdynamic physiology of circulation can exacerbate many cardiovascular disorders. Congestive heart failure (CHF) usually occurs during late pregnancy, which is significantly associated with a high level of maternal and neonatal morbidities and mortalities. The profile of women who develop peripartum CHF (PCHF) is unknown. Read More

Eur J Obstet Gynecol Reprod Biol 2017 Sep 1;217:137-143. Epub 2017 Sep 1.

Paris 13 University, Sorbonne Paris Cité, AP-HP, Jean Verdier Hospital, Department of Endocrinology-Diabetology-Nutrition, CRNH-IdF, Bondy, France; Paris 13 University, Sorbonne Paris Cité, UMR U1153 INSERM/U11125 INRA/CNAM/Université Paris13, Unité de Recherche Epidémiologique Nutritionnelle, Bobigny, France.

Objectives: To study the role of ovarian stimulation procedures on the risk of pregnancy-induced hypertension, gestational diabetes mellitus and neonatal outcomes according to women's characteristics and the causes of infertility.

Design: Retrospective, observational, case/control study.

Patients: Spontaneous pregnancies (group A, n=8107), pregnancies achieved after mild ovarian ovulation induction without other Assisted Reproductive Technology (ART) procedures (group B, n=44), pregnancies after mild ovarian stimulation and ART procedures (group C, n=53) or pregnancies after multi (>2) follicular stimulation with gonadotrophin therapy and ART procedures (group D, n=133); all of the groups had identical protocols for prenatal care. Read More

Diabetologia 2017 Sep 11. Epub 2017 Sep 11.

Department of Public Health, University of Helsinki, Helsinki, Finland.

Aims/hypothesis: The aim of this study was to explore the association between type 1 diabetes and reproductive health indicators in women, focusing on termination of pregnancy and sterilisation.

Methods: We conducted a registry-based cohort study involving 2281 women with childhood-onset type 1 diabetes, matched for age and birthplace with women without diabetes: two control participants for each woman with diabetes. We compared the frequencies of termination of pregnancy and sterilisation over a 25 year period between women with type 1 diabetes and women without, and estimated standardised incidence ratios (SIRs). Read More

Sci Rep 2017 Sep 11;7(1):11107. Epub 2017 Sep 11.

Department of Obstetrics, Gynecology and Reproductive Sciences,University of Maryland School of Medicine, Baltimore, Maryland, USA.

Diabetes mellitus in early pregnancy can cause neural tube defects (NTDs) in embryos by perturbing protein activity, causing cellular stress, and increasing programmed cell death (apoptosis) in the tissues required for neurulation. Hyperglycemia augments a branch pathway in glycolysis, the hexosamine biosynthetic pathway (HBP), to increase uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc). GlcNAc can be added to proteins by O-GlcNAc transferase (OGT) to regulate protein activity. Read More

Environ Int 2017 Sep 8;108:253-260. Epub 2017 Sep 8.

Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark; Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark.

Background: Road traffic is a main source of air pollution and noise. Both exposures have been associated with type 2 diabetes, but associations with gestational diabetes mellitus (GDM) have been studied less.

Objectives: We aimed to examine single and joint associations of exposure to air pollution and road traffic noise on GDM in a prospective cohort. Read More

Biomark Med 2017 Sep 11. Epub 2017 Sep 11.

Department of Immunology, School of Biology & Basic Medical Sciences, Medical College, Soochow University, Suzhou, China.

Aim: Accumulating evidence suggested that challenge of the maternal-fetal interaction during pregnancy might cause the impairment of immunological hemostasis and lead to gestational diabetes mellitus (GDM) pathological process. Immune checkpoint molecule PD-1 is one of the critical molecule balancing immune response and immunological tolerance.

Methods: PD-1 expressions on T-cell subsets of GDM patients and control groups were measured via flow cytometric analysis and followed up. Read More

Prostaglandins Leukot Essent Fatty Acids 2017 Aug 15. Epub 2017 Aug 15.

Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, India. Electronic address:

Maternal nutrition plays a crucial role in influencing fetal growth and birth outcome. Any nutritional insult starting several weeks before pregnancy and during critical periods of gestation is known to influence fetal development and increase the risk for diseases during later life. Literature suggests that chronic adult diseases may have their origin during early life - a concept referred to as Developmental Origins of Health and Disease (DOHaD) which states that adverse exposures early in life "program" risks for later chronic disorders. Read More

BMC Pregnancy Childbirth 2017 Sep 7;17(1):293. Epub 2017 Sep 7.

Department of Public and Occupational Health and, Amsterdam Public Health research institute, VU University Medical Centre, Van der Boechorststraat 7, 1081BT Amsterdam, Amsterdam, The Netherlands.

Background: Process evaluation is an essential part of designing and assessing complex interventions. The vitamin D and lifestyle intervention study (DALI) study is testing different strategies to prevent development of gestational diabetes mellitus among European obese pregnant women with a body mass index ≥29 kg/m(2). The intervention includes guidance on physical activity and/or healthy eating by a lifestyle coach trained in motivational interviewing (MI). Read More

Minerva Endocrinol 2017 Sep 7. Epub 2017 Sep 7.

Department of Endocrinology, Suizhou Hospital, Hubei University of Medicine, Hubei, China -

Background: To investigate the levels of thyroid hormone and antithyroid antibodies and their relationship with pregnancy outcome in patients with gestational diabetes mellitus (GDM) and diabetic patients.

Methods: Fifty patients with GDM and 50 pregnant patients with diabetes were selected. Their levels of fasting blood glucose (FBG), glycosylated hemoglobin, FT3, FT4, TGab, TSH, TPOab were measured until parturition. Read More

Int Ophthalmol 2017 Sep 6. Epub 2017 Sep 6.

University Malaya Medical Center, Lembah Pantai, 59100, Kuala Lumpur, Malaysia.

Background: Purpose of this study is to evaluate changes in the central corneal thickness (CCT) in patients during the third trimester and postpartum phases of normal pregnancy, pregestational diabetes mellitus (DM), and gestational diabetes mellitus (GDM).

Methods: This was a prospective study. Patients that fulfilled the inclusion criteria were recruited from the obstetric clinic. Read More

J Matern Fetal Neonatal Med 2017 Sep 19:1-4. Epub 2017 Sep 19.

b Dipartimento di Medicina Clinica e Sperimentale , Università degli Studi di Messina , Messina , Italy.

Background: Some studies have already investigated about the short-term favorable metabolic effects of breastfeeding in women with previous gestational diabetes mellitus (GDM).

Aim: The aim of our study is to confirm whether the positive effects reported are maintained in the larger cohorts of patients with mild form of gestational diabetes mellitus (GDM) because recently diagnosed according to IADPSG criteria.

Materials And Methods: This retrospective study includes 97 evaluable consecutive women with prior GDM who have the follow-up oral glucose tolerance test at least 3 months after delivery. Read More

Cureus 2017 Jul 3;9(7):e1420. Epub 2017 Jul 3.

Department of Internal Medicine, MGM Medical College, Navi Mumbai, India.

Introduction During the last two trimesters of pregnancy, glucose is spared (for the foetus), while the concentration of fatty acids in plasma increases, which can create complications like preeclampsia, gestational diabetes mellitus (GDM), and preterm delivery. Aim To study the association of serum lipid levels during the second and third trimesters with the development of pregnancy-associated diseases, such as preeclampsia, GDM, and preterm delivery. Methods and Materials The present study was carried out at MGM Hospital, Navi Mumbai, India. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Aug;42(8):966-972

Customer Service Center, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, China.

Objective: To study the effect of one-day outpatient intervention on gestational diabetes mellitus (GDM) patients, and to explore the pregnancy outcome relevant to GDM patients and their fetus.
 Methods: The GDM patients were divided into two groups according to their own intention to the one-day outpatient. According to systematic sampling method, we chose 200 GDM patients from the above 2 groups, respectively. Read More

J Obstet Gynaecol India 2017 Oct 10;67(5):343-348. Epub 2017 Mar 10.

Institute of Obstetrics and Gynaecology, Govt. Hospital for Women and Children, 40/78, Second Cross Street, Collectorate Colony, Aminjikarai, Chennai, Tamil Nadu 600 029 India.

Introduction: Complete loss of vision is an uncommon ocular complication of pre-eclampsia/eclampsia. The conditions which lead to visual loss in pre-eclampsia include cortical blindness, retinal detachment, retinal vascular thrombosis and optic nerve atrophy.

Objectives: The objective was to describe the cause, clinical course and prognosis in blindness complicating pre-eclampsia. Read More

Drugs 2017 Sep 2. Epub 2017 Sep 2.

University of Toronto, Toronto, ON, Canada.

Gestational diabetes mellitus (GDM) is associated with an increased risk of adverse pregnancy outcomes in the setting of poor glycemic control. The initial management for GDM includes intensive lifestyle modification, which often requires behavioral and nutritional changes to optimize glycemic control. Pharmacotherapy for GDM is initiated when glycemic targets are not met. Read More

Placenta 2017 Sep 29;57:129-136. Epub 2017 Jun 29.

Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Introduction: The prorenin (PR) receptor [(P)RR] contributes to the regulation of the tissue renin-angiotensin system (RAS) and Wnt signaling, which is involved in embryogenesis and the pathological progression of malignant tumors and diabetes mellitus. Placental (P)RR is significantly upregulated in placental tissues from preeclamptic women. However, because it cannot be examined during pregnancy, the chronological relationship between the acceleration of tissue RAS and the disease state of hypertensive disorder of pregnancy (HDP) has not been reported. Read More

Diab Vasc Dis Res 2017 Aug 1:1479164117728011. Epub 2017 Aug 1.

1 Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Background: Women with a history of gestational diabetes mellitus and preeclampsia are at increased risk of cardiovascular disease later in life, but the mechanism remains unclear. The aim of the study was to evaluate the association between CXC chemokine ligand 16 and indices of glucose metabolism, dyslipidemia and systemic inflammation in gestational diabetes mellitus and preeclampsia.

Methods: This sub-study of the population-based prospective cohort included 310 women. Read More

Scand J Caring Sci 2017 Aug 30. Epub 2017 Aug 30.

Department of Public Health, Aarhus University, Aarhus, Denmark.

Background: Women with gestational diabetes mellitus (GDM) receive acute but short-term care during pregnancy. There is less direct support during the postpartum period; women are offered general advice on how to follow a healthy lifestyle to avoid developing future type 2 diabetes. Observational studies suggest that a substantial proportion of women with prior GDM do not sustain recommended lifestyle changes postpartum. Read More

Sci Rep 2017 Aug 29;7(1):9654. Epub 2017 Aug 29.

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.

The genetic variants near the Melanocortin-4 receptor gene (MC4R), a key protein regulating energy balance and adiposity, have been related to obesity and glucose metabolism. We aimed to assess whether the MC4R genotype affected longitudinal changes in body weight and glucose metabolism biomarkers among women with prior gestational diabetes mellitus (GDM). The MC4R genotype, postpartum weight reduction, and glycemic changes between after delivery and pregnancy were assessed in a cohort of 1208 Chinese women who had experienced GDM. Read More

Zhonghua Fu Chan Ke Za Zhi 2017 Aug;52(8):514-520

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

Objective: To evaluate the maternal age at delivery in Beijing and the effect of maternal age on pregnancy outcomes. Methods: A retrospective analysis was conducted on 14 970 singleton pregnancies from 15 hospitals in Beijing from June 20(th) to November 30(th) in 2013. These hospitals were sorted by the numbers of delivery and chosen as clusters by systemic cluster sampling method. Read More

Zhonghua Fu Chan Ke Za Zhi 2017 Aug;52(8):508-513

Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Objective: To explore the association between maternal age and perinatal outcomes. Methods: Totally, 3 151 women with advanced maternal age and 6 098 women younger than 35 years old who delivered in Beijing Obstetrics and Gynecology Hospital in 2016 were recruited. Their clinic characteristics and perinatal outcomes were collected to divide into 3 groups based on delivery age, Group 1 (aged 35-39 years, 2 683 cases), Group 2 (aged ≥40 years, 366 cases) and the control group (aged<35 years, 6 098 cases). Read More

Adv Exp Med Biol 2017 ;975:295-305

Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

This study tests the hypothesis that perinatal taurine supplementation prevents diabetes mellitus and hypertension in adult offspring of maternal diabetic rats. Female Wistar rats were fed normal rat chow and tap water with (Diabetes group) or without diabetic induction by intraperitoneal streptozotocin injection (Control group) before pregnancy. Then, they were supplemented with 3% taurine in water (Control+T and Diabetes+T groups) or water alone from conception to weaning. Read More

Mol Med Rep 2017 Oct 14;16(4):5189-5194. Epub 2017 Aug 14.

Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, P.R. China.

Gestational diabetes mellitus (GDM) is characterized by an initial diagnosis of glucose intolerance during pregnancy. There is increasing evidence supporting the association between GDM and the inhibited development of several organs in offspring. In the present study, a murine GDM model was established in mice by intraperitoneal injection of streptozotocin to evaluate the effect of maternal diabetes on the initiation of meiosis in female germ cells of offspring. Read More

Gynecol Endocrinol 2017 Aug 28:1-7. Epub 2017 Aug 28.

a Department of Obstetrics and Gynecology , Maastricht University Medical Center , Maastricht , The Netherlands.

Background: Gestational diabetes mellitus (GDM) complicates 1-14% of pregnancies and relates to increased risk of adverse obstetric outcomes. Currently GDM is diagnosed using an oral glucose tolerance test (OGTT), which is burdensome and time intensive.

Objective: To compare current literature on whether the homeostatic model assessment beta cell function (HOMA-β) is an accurate predictor of an abnormal OGTT in pregnant women. Read More

Sex Reprod Healthc 2017 Oct 27;13:14-22. Epub 2017 Feb 27.

The University of Texas at El Paso, College of Health Sciences, Department of Psychology, 500 W University Ave, El Paso, TX 79902, United States. Electronic address:

Background And Objective: Gestational Diabetes Mellitus (GDM) is a serious health concern for pregnant women, with Hispanic women at particular risk for developing the condition. The aim of this review was to critically examine GDM intervention programs for Hispanic women, in the United States of America (US).

Methods: English and Spanish electronic databases were searched for relevant studies published between 1995 and 2015. Read More

BMC Med 2017 Aug 28;15(1):163. Epub 2017 Aug 28.

School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK.

Background: Personalised treatment that is uniquely tailored to an individual's phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases. For type 2 diabetes, the importance of the underlying clinical heterogeneity of the condition is emphasised and a range of treatments are now available, with personalised approaches being developed. While a close connection between risk factors for type 2 diabetes and gestational diabetes has long been acknowledged, stratification of screening, treatment and obstetric intervention remains in its infancy. Read More

Diabetologia 2017 Aug 25. Epub 2017 Aug 25.

School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.

Aims/hypothesis: The role of glucose effectiveness (S G) in training-induced improvements in glucose metabolism in individuals with type 2 diabetes is unknown. The objectives and primary outcomes of this study were: (1) to assess the efficacy of interval walking training (IWT) and continuous walking training (CWT) on S G and insulin sensitivity (S I) in individuals with type 2 diabetes; and (2) to assess the association of changes in S G and S I with changes in glycaemic control.

Methods: Fourteen participants with type 2 diabetes underwent three trials (IWT, CWT and no training) in a crossover study. Read More

Diabetes Metab Res Rev 2017 Aug 24. Epub 2017 Aug 24.

Department of Internal Medicine, Charles University 2nd Faculty of Medicine, Prague, Czech Republic.

Background: MODY (Maturity-onset diabetes of the young) is a genetically linked group of clinically heterogeneous subtypes of diabetes. Roughly 5% of people with diabetes mellitus diagnosed prior to age 45 have MODY diabetes, the majority of whom have been erroneously diagnosed as patients with either Type 1 or Type 2 diabetes and, as a result, have been improperly treated. Genetic identification of MODY diabetes and its subtypes allows proper treatment and enables clinicians to switch many patients to oral antidiabetic agents, mainly sulphonylureas. Read More

Endocrinology 2017 Aug;158(8):2522-2532

School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Autophagy is a dynamic process that degrades and recycles cellular organelles and proteins to maintain cell homeostasis. Alterations in autophagy occur in various diseases; however, the role of autophagy in gestational diabetes mellitus (GDM) is unknown. In the present study, we characterized the roles and functions of autophagy in GDM patient samples and extravillous trophoblasts cultured with glucose. Read More