149,779 results match your criteria Diabetes Mellitus Type 2


Changes of saliva microbiota in the onset and after the treatment of diabetes in patients with periodontitis.

Aging (Albany NY) 2020 07 7;12. Epub 2020 Jul 7.

Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.

The relationship between type 2 diabetes mellitus (T2DM) and oral microbiota is still insufficiently recognized. In the present study, we compared the salivary microbiome of nondiabetic individuals, treatment-naïve diabetic patients, and diabetic patients treated with metformin or a combination of insulin and other drugs. The α- and β-diversity demonstrated significant differences in the salivary microbiome between the nondiabetic people and patients with a history of diabetes, while little divergence was found among individuals with a history of diabetes. Read More

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http://dx.doi.org/10.18632/aging.103399DOI Listing

Non-Dietary Factors Associated with Glycemic Status among Adults Diagnosed with Type 2 Diabetes Mellitus in Malawi.

Soc Work Public Health 2020 Jul 7:1-12. Epub 2020 Jul 7.

Department of Food Science and Human Nutrition, Michigan State University , East Lansing, Michigan, USA.

We assessed glycemic status and associations with socio-demographic, biomedical, anthropometric, and physical activity (PA) levels among adults with type 2 diabetes mellitus (T2DM) (n = 428; urban n = 288; semi-urban n = 140) using a cross-sectional study. Multivariate linear regression was used to determine factors associated with glycosylated hemoglobin (A1C) . A1C was clinically elevated ≥8% for 60. Read More

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http://dx.doi.org/10.1080/19371918.2020.1785367DOI Listing

Metabolic syndrome coexists with adult Léri-Weill dyschondrosteosis: A case report.

J Diabetes Investig 2020 Jul 7. Epub 2020 Jul 7.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, P. R. China.

Léri-Weill dyschondrosteosis (LWD) is usually caused by haploinsufficiency of the short stature homeobox-containing gene (SHOX). The clinical manifestation of this disease is classic triad which are short stature, mesomelia, and Madelung deformity. LWD also includes other features such as high body mass index (BMI). Read More

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http://dx.doi.org/10.1111/jdi.13350DOI Listing

[Association of APOA5-1131T>C polymorphism with obesity in coronary artery disease].

Turk Kardiyol Dern Ars 2020 Jul;48(5):461-471

Department of Genetics, Aziz Sancar Institute for Experimental Medicine, Istanbul University, İstanbul.

Objective: Genetic risk factors that cause coronary artery disease (CAD) demonstrate variations in different populations. In this study, a single nucleotide polymorphism in the APOA5 gene was targeted to determine genetic contributors to atherosclerotic CAD. The effects of this polymorphism on the development of CAD and known risk factors of the disease were examined. Read More

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http://dx.doi.org/10.5543/tkda.2020.62874DOI Listing

Men with type 2 diabetes mellitus have a lower detection rate of prostate cancer.

Int J Urol 2020 Jul 6. Epub 2020 Jul 6.

Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.

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http://dx.doi.org/10.1111/iju.14304DOI Listing

has_circ_CCNB1 and has_circ_0009024 function as potential biomarkers for the diagnosis of type 2 diabetes mellitus.

J Clin Lab Anal 2020 Jul 6:e23439. Epub 2020 Jul 6.

Department of Endocrinology, School of Medicine, Geriatric Research Center, Jinling Hospital, Nanjing University, Nanjing, China.

Circular RNAs (circRNAs) have been reported to be associated with various diseases, including type 2 diabetes mellitus (T2DM). The aim of present study was to investigate the clinical value of has_circ_CCNB1 and has_circ_0009024 in T2DM. Serum samples from patients with T2DM (n = 166) and healthy volunteers (n = 166) were recruited. Read More

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http://dx.doi.org/10.1002/jcla.23439DOI Listing

NR2F2 plays a major role in insulin-induced epithelial-mesenchymal transition in breast cancer cells.

BMC Cancer 2020 Jul 6;20(1):626. Epub 2020 Jul 6.

Department of Pathophysiology, Weifang Medical University, Weifang, 261053, China.

Background: The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclear receptor subfamily 2, group F, member 2 (NR2F2) has been implicated in the development of breast cancer, however its contribution to insulin-induced EMT in breast cancer remains unclear. Read More

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http://dx.doi.org/10.1186/s12885-020-07107-6DOI Listing

Prior bariatric surgery and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus: hint from National Inpatient Sample Database.

Cardiovasc Diabetol 2020 Jul 6;19(1):103. Epub 2020 Jul 6.

Department of Endocrinology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhong Shan Er Lu, Guangzhou, 510080, China.

Background: Both diabetes and obesity are risk factors for perioperative major adverse events. This study aims to evaluate the association between prior bariatric surgery (prior-BS) and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus (T2DM).

Methods: We used the National Inpatient Sample Database to identify T2DM patients undergoing major noncardiac surgery from 2006 to 2014. Read More

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http://dx.doi.org/10.1186/s12933-020-01084-7DOI Listing

Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights.

Int J Mol Sci 2020 Jul 2;21(13). Epub 2020 Jul 2.

Fundación Biofisika Bizkaia, Barrio Sarriena s/n, 48940 Leioa, Spain.

Statins are the gold-standard treatment for the prevention of primary and secondary cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety and relative tolerability of statins, observational studies, clinical trials and meta-analyses indicate an increased risk of developing new-onset type 2 diabetes mellitus (T2DM) after long-term statin treatment. It has been shown that statins can impair insulin sensitivity and secretion by pancreatic β-cells and increase insulin resistance in peripheral tissues. Read More

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http://dx.doi.org/10.3390/ijms21134725DOI Listing

Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis.

Biomedicines 2020 Jul 2;8(7). Epub 2020 Jul 2.

Institute of Visual and Analytic Computing, University of Rostock, Albert-Einstein-Straße 22, 18059 Rostock, Germany.

Optical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We introduce an enhanced deviation map-based analysis (MA) and demonstrate its effectiveness in detecting early changes in intraretinal layer thickness in adults with type 2 diabetes mellitus (T2DM) compared to common early treatment diabetic retinopathy study (ETDRS) grid-based analysis (GA). Read More

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http://dx.doi.org/10.3390/biomedicines8070190DOI Listing

The Impact of Sugar-Sweetened Beverage Consumption on the Liver: A Proteomics-based Analysis.

Antioxidants (Basel) 2020 Jul 1;9(7). Epub 2020 Jul 1.

Center for Cardio-Metabolic Research in Africa (CARMA), Department of Physiological Sciences, Stellenbosch University, Stellenbosch 7600, South Africa.

Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this study aimed to obtain greater mechanistic insights. Male Wistar rats (~200 g) were gavaged with a local SSB every day for a period of six months while the control group was gavaged with an iso-volumetric amount of water. Read More

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http://dx.doi.org/10.3390/antiox9070569DOI Listing

Relationship between plasma total homocysteine and the severity of renal function in Chinese patients with type 2 diabetes mellitus aged ≥75 years.

Medicine (Baltimore) 2020 Jul;99(27):e20737

Department of Endocrinology and Metabolism, First Affiliated Hospital of Soochow University.

We aimed to investigate the relationship between total homocysteine (tHcy) levels in the plasma and renal function severity in patients with type 2 diabetes mellitus (T2DM) aged ≥75 years.We included 221 patients with T2DM aged ≥60 years (59 aged ≥75 years).tHcy levels among the 4 groups of patients aged ≥60 years significantly differed, but not in those aged ≥75 years. Read More

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http://dx.doi.org/10.1097/MD.0000000000020737DOI Listing

Mitochondrial Haplogroup Reveals the Genetic Basis of Diabetes Mellitus Type 2 Comorbidity in Psoriasis.

Med Princ Pract 2020 Jul 6. Epub 2020 Jul 6.

Objective: Published data has shown a clear link between psoriasis (Ps) and the increasing prevalence of comorbid conditions, such as diabetes mellitus type 2 (DM2). The mitochondrial genomic haplogroup's role in the potential coexistence of psoriasis and DM2 comorbidity is the subject of this study.

Material And Method: Ninety-eight Kuwaiti individuals were recruited in 4 cohorts (20 healthy controls (HC), 15 with DM2, 34 with psoriasis, and 29 with psoriasis and diabetes mellitus (PsDM2). Read More

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http://dx.doi.org/10.1159/000509937DOI Listing

Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet.

J Nutr Biochem 2020 Jun 2;84:108441. Epub 2020 Jun 2.

Department of Biochemistry, Christian Medical College, Vellore 632002, Tamil Nadu, India. Electronic address:

Type 2 diabetes mellitus (T2DM) and insulin resistance (IR) have been associated with dysregulation of iron metabolism. The basis for this association is not completely understood. To attempt to investigate this, we studied temporal associations between onset of insulin resistance (IR) and dysregulated iron homeostasis, in a mouse model of T2DM. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108441DOI Listing

Metabolic endoscopy: Today's science-tomorrow's treatment.

United European Gastroenterol J 2020 Jul;8(6):685-694

Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Obesity, type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis are increasing pandemic metabolic disorders. Lifestyle intervention (LSI) is the cornerstone treatment for these but is successful as standard care alone in only a few patients, given the modest weight loss at mid and long term. Conversely, bariatric surgery is the only proven effective treatment for these metabolic disorders, albeit offered only in a small percentage of cases because of its invasiveness and cost. Read More

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http://dx.doi.org/10.1177/2050640620926837DOI Listing

Fixed-Ratio Combinations of Basal Insulin and Glp-1ra in the Management of Type 2 Diabetes Mellitus: Highlight from Literature.

Endocr Metab Immune Disord Drug Targets 2020 Jul 5. Epub 2020 Jul 5.

Interdisciplinary Department of Medicine - Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases. University of Bari "Aldo Moro", Bari. Italy.

Introduction: New evidences suggest that combining basal insulin with glucagone-like peptide 1 receptor agonists (GLP-1RA) in patients with type 2 diabetes could promptly ameliorate the glucose control and prevent both hypoglycaemia and weight gain compared with more intensive insulin regimens.

Aim Of The Study: To review the efficacy/effectiveness and safety of fixed-ratio combinations of basal insulin and GLP-1RA (FRCs).

Methods: We asked the web for freely available medical data concerning the aim of the study, and selected original articles, randomized clinical trials (RCTs), clinical reviews, and meta-analysis written in English. Read More

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http://dx.doi.org/10.2174/1871530320666200705211224DOI Listing

Effects of Antidiabetic Drugs on Muscle Mass in Type 2 Diabetes Mellitus.

Curr Diabetes Rev 2020 Jul 5. Epub 2020 Jul 5.

Department of Diabetes and Metabolism, Ise Red Cross Hospital, Mie. Japan.

Background: When considering the administration of glucagon-like peptide-1 receptor agonists (GLP-1RAs), sodium-glucose cotransporter-2 (SGLT2) inhibitors, or metformin, it is important to understand their weight loss effect as well as the degree of muscle loss caused by each drug in clinical practice.

Objective: To comparatively examine the effects of GLP-1RAs and oral antidiabetic drugs, including SGLT2 inhibitors and metformin, on muscle mass and body weight in patients with type 2 diabetes via a network meta-analysis of randomized controlled trials.

Methods: We included randomized controlled trials evaluating the effects of antidiabetic drugs on muscle mass and body weight. Read More

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http://dx.doi.org/10.2174/1573399816666200705210006DOI Listing

GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.

Curr Diabetes Rev 2020 Jul 5. Epub 2020 Jul 5.

Biomedical Research Center [BRC], Qatar University, Doha. Qatar.

Background: Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition.

Discussion: The anti-adipogenic transcription factor GATA-3 was identified as one of the potential molecular targets responsible for impairment of adipogenesis. The expression of GATA-3 is higher in insulin resistant obese individuals compared to BMI-matched insulin sensitive counterparts. Read More

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http://dx.doi.org/10.2174/1573399816666200705210417DOI Listing

Essential Amino Acids-Essential in Arterial Thrombosis.

Circulation 2020 Jul 6;142(1):65-67. Epub 2020 Jul 6.

Aab Cardiovascular Research Institute (Z.T.H., C.N.M.), University of Rochester School of Medicine, New York.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046817DOI Listing

Lower intake of saturated fatty acids is associated with persistently higher arterial stiffness in patients with type 2 diabetes.

J Diabetes Investig 2020 Jul 6. Epub 2020 Jul 6.

Department of Metabolism & Endocrinology, Tokyo, Japan.

Aim/introduction: There are few studies to investigate between the relationship between macronutrients and longitudinal changes in arterial stiffness in patients with type 2 diabetes mellitus. This exploratory study sought to determine whether macronutrients were correlated with increased arterial stiffness independently of conventional atherosclerotic risk factors.

Materials And Methods: The study subjects comprised 733 type 2 diabetes outpatients who had no apparent history of cardiovascular diseases. Read More

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http://dx.doi.org/10.1111/jdi.13347DOI Listing

Association of Body Mass Index in Youth With Adult Cardiometabolic Risk.

J Am Heart Assoc 2020 Jul 4:e015288. Epub 2020 Jul 4.

Menzies Institute for Medical ResearchUniversity of Tasmania Hobart Australia.

Background Whether long-term exposure to overweight or obesity from early life to adulthood has a detrimental influence on health outcomes is unknown. We aimed to investigate whether duration of overweight or obesity from youth to adulthood is associated with adult cardiometabolic risk. Methods and Results A population-based cohort study was performed of 1268 youths, aged 3 to 18 years, with follow-ups at 3, 6, 9, 12, 21, 27, and 31 years. Read More

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http://dx.doi.org/10.1161/JAHA.119.015288DOI Listing

Patient and Provider Perspectives on a Novel Mobile Health Intervention for Low-Income Pregnant Women With Gestational or Type 2 Diabetes Mellitus.

J Diabetes Sci Technol 2020 Jul 5:1932296820937347. Epub 2020 Jul 5.

Departments of Obstetrics and Gynecology and Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Management of diabetes mellitus (DM) during pregnancy is burdensome given the intensity of required patient engagement and skills, especially for women with greater social disadvantage. Mobile health (mHealth) technology is a promising avenue for DM health promotion, but few evidence-based mHealth tools exist for pregnancy. Thus, we designed a theory-driven mHealth tool called SweetMama, and planned a priori to gather usability and acceptability feedback from patients and providers to ensure a user-centered design. Read More

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http://dx.doi.org/10.1177/1932296820937347DOI Listing

Sodium glucose cotransporter-2 inhibitor was associated with an improvement in left ventricular systolic function in patients with type 2 diabetes mellitus with impaired left ventricular systolic function.

ESC Heart Fail 2020 Jul 6. Epub 2020 Jul 6.

The Cardiovascular Department, Chang Gung Memorial Hospital, Linkou, Taoyuan, 33305, Taiwan.

Aims: Recent studies indicated that sodium glucose cotransporter-2 inhibitors (SGLT2i) reduced heart failure hospitalization in patients with type 2 diabetes mellitus (T2DM). However, whether SGTL2i can improve left ventricular (LV) systolic and diastolic function remained unclear. This study aimed to compare the change in echocardiographic parameters in T2DM patients receiving SGLT2i with a different baseline LV ejection fraction (LVEF). Read More

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http://dx.doi.org/10.1002/ehf2.12877DOI Listing

miR-217/Mafb Axis Involve in High Glucose-Induced β-TC-tet Cell Damage Via Regulating NF-κB Signaling Pathway.

Biochem Genet 2020 Jul 5. Epub 2020 Jul 5.

Department of Endocrinology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, P.R. China.

We attempt to explore the role of miR-217 during the process of type 2 diabetes mellitus (T2DM). Mouse β-TC-tet was dealt with 16.7 mM glucose (HG) to imitate the cells in T2DM. Read More

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http://dx.doi.org/10.1007/s10528-020-09984-9DOI Listing

Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study.

J Diabetes Res 2020 13;2020:3982831. Epub 2020 Jun 13.

Endocrinology Department, Peking University International Hospital, Beijing, China.

Objective: To analyze the association between uric acid levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus.

Methods: We retrospectively analyzed 262 postmenopausal women with type 2 diabetes mellitus, to assess uric acid levels and bone mineral density using the score of dual-energy X-ray absorptiometry.

Results: (1) Women in the osteoporosis group demonstrated higher uric acid levels and lower estimated glomerular filtration rate ( < 0. Read More

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http://dx.doi.org/10.1155/2020/3982831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313031PMC

Is Telenursing an Effective Method to Control BMI and HbA1c in Illiterate Patients Aged 50 Years and Older With Type 2 Diabetes? A Randomized Controlled Clinical Trial.

J Caring Sci 2020 Jun 1;9(2):73-79. Epub 2020 Jun 1.

Department of Nursing, School of Nursing, Lorestan University of Medical Sciences, Khorramabad, Iran.

Telenursing is a simple method to provide and maintain nursing care for patients with chronic illness such as diabetes. This study aimed to determine the effectiveness of telenursing on body mass index (BMI) and glycosylated hemoglobin (HbA1c) in illiterate patients aged 50 years and older with type 2 diabetes. A randomized controlled clinical trial was performed. Read More

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http://dx.doi.org/10.34172/JCS.2020.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322411PMC

Dimensions, application, and outcomes of person-centered self-management interventions for those living with type 2 diabetes: A scoping review.

Patient Educ Couns 2020 Jun 22. Epub 2020 Jun 22.

School of Nursing, University of Sherbrooke, Longueuil, Québec, J4K 0A8, Canada. Electronic address:

Objectives: To explore which dimensions of the person-centered approach (PCA) are adopted in self-management interventions, how they are applied, and its outcomes.

Methods: A review team carried out a scoping review using the methodology of Arksey and O'Malley on diabetes mellitus type 2, person-centered care, and self-management.

Results: Of the 364 titles identified, 22 articles were included in this review. Read More

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http://dx.doi.org/10.1016/j.pec.2020.06.020DOI Listing

The relationship between Helicobacter pylori and chronic kidney disease: update 2020.

Minerva Gastroenterol Dietol 2020 Jul 3. Epub 2020 Jul 3.

Renal Transplantation Center "A. Vercellone", Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.

A number of studies has confirmed that the epidemiology of Helicobacter pylori (H. pylori) is changing worldwide, with a decrease especially in developed Countries. Nevertheless, since this Gram-negative bacterium infects almost 50% of the world's population, it remains a global problem. Read More

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http://dx.doi.org/10.23736/S1121-421X.20.02729-4DOI Listing

Relationships between microvascular complications of diabetes mellitus and levels of macro and trace elements.

Minerva Endocrinol 2020 Jul 3. Epub 2020 Jul 3.

Internal Medicine, Girne Univercıty, Kuzey Kıbrıs Türk Cumhuriyeti, Ciprus.

Background: The aim of this study was to determine relationships between microvascular complications of type 2 diabetes mellitus (T2DM) and trace element levels measured by ICP-MS.

Methods: One hundred eighteen patients with T2DM, ages 30-65 years, and 40 control subjects were included in the study. The T2DM patients were divided into three groups according to their types of microvascular complications. Read More

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http://dx.doi.org/10.23736/S0391-1977.20.03139-9DOI Listing

Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type 2 diabetes mellitus: Sub-analysis of a prospective, randomized, controlled study (PRIME-V study).

J Diabetes Investig 2020 Jul 4. Epub 2020 Jul 4.

Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba, 260-8677, Japan.

Introduction: Recent randomized clinical trials have suggested that sodium-glucose co-transporter-2 (SGLT2) inhibitors may reduce cardiovascular events and heart failure and have renal protective effects. Despite these remarkable benefits, the effects of SGLT2 inhibitors on bone and muscle are unclear.

Methods: A sub-analysis of a randomized controlled study was performed to evaluate the effects of the SGLT2 inhibitor, ipragliflozin, versus metformin on bone and muscle in Japanese patients with type 2 diabetes mellitus (baseline BMI ≥ 22 kg/m and HbA1c 7-10 %) who were already receiving sitagliptin. Read More

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http://dx.doi.org/10.1111/jdi.13340DOI Listing

A comparative study of microbial community and functions of type 2 diabetes mellitus patients with obesity and healthy people.

Appl Microbiol Biotechnol 2020 Jul 4. Epub 2020 Jul 4.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.

The gut microbiota is crucial in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the metabolism of T2DM patients is not well-understood. We aimed to identify the differences on composition and function of gut microbiota between T2DM patients with obesity and healthy people. Read More

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http://dx.doi.org/10.1007/s00253-020-10689-7DOI Listing

Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia.

J Alzheimers Dis 2020 Jul 2. Epub 2020 Jul 2.

Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.

We explored the association of type 2 diabetes related blood markers with brain amyloid accumulation on PiB-PET scans in 41 participants from the FINGER PET sub-study. We built logistic regression models for brain amyloid status with12 plasma markers of glucose and lipid metabolism, controlled for diabetes and APOEɛ4 carrier status. Lower levels of insulin, insulin resistance index (HOMA-IR), C-peptide, and plasminogen activator (PAI-1) were associated with amyloid positive status, although the results were not significant after adjusting for multiple testing. Read More

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http://dx.doi.org/10.3233/JAD-200145DOI Listing

The impact of personality traits on medication adherence and self-care in patients with type 2 diabetes mellitus: The moderating role of gender and age.

J Psychosom Res 2020 Jun 28;136:110178. Epub 2020 Jun 28.

Department of Health Education and Promotion, School of Health, Qom University of Medical Sciences, Qom, Iran; South Tehran Heath Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: This study aimed to investigate the role of the five-factor model of personality (FFM) and the moderating role of gender and age in predicting medication adherence (MA) and self-care behaviors (SCB) among Iranian patients with type 2 diabetes mellitus (T2DM).

Methods: This study was conducted on 495 patients with T2DM (73.5% female; n = 364) from two major cities of Iran (Tehran and Qom) in 2019. Read More

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http://dx.doi.org/10.1016/j.jpsychores.2020.110178DOI Listing

Long-term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus.

Cardiovasc Diabetol 2020 Jul 4;19(1):100. Epub 2020 Jul 4.

Department of Cardiology, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.

Background: In this study, we compared the outcomes of medical therapy (MT) with successful percutaneous coronary intervention (PCI) in chronic total occlusions (CTO) patients with and without type 2 diabetes mellitus.

Methods: A total of 2015 patients with CTOs were stratified. Diabetic patients (n = 755, 37. Read More

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http://dx.doi.org/10.1186/s12933-020-01087-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335447PMC

Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus.

Stem Cell Res 2020 Jun 26;47:101880. Epub 2020 Jun 26.

Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University Health System (NUHS), National University of Singapore, 1E Kent Ridge Rd, Singapore 119228, Singapore.

Gestational diabetes mellitus (GDM) has been strongly associated with an increased risk of type 2 diabetes mellitus (T2DM) in later child and adulthood. The human umbilical cord and its contents are of fetal origin and represent the fetus genetically and physiologically. Since it is not possible to obtain tissues from the fetus and newborn to investigate the association between GDM and later T2DM, we reprogrammed the stem cells from the Wharton's jelly of umbilical cords (hWJSCs) of GDM and non-GDM mothers into induced pluripotent stem cells (iPSCs) and then differentiated the iPSCs into insulin-producing cells (IPCs) to provide pancreatic tissues that represent the fetus of GDM and normal mothers. Read More

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http://dx.doi.org/10.1016/j.scr.2020.101880DOI Listing

Resolution of Metabolic syndrome with reduction of visceral adipose tissue in a 47 year old patient with Type 2 Diabetes Mellitus.

Diabetes Metab Syndr 2020 Jun 16;14(5):1001-1004. Epub 2020 Jun 16.

20Lighter, LLC Cheyenne, Wyoming, 82007, USA. Electronic address:

Background And Aims: Metabolic syndrome (MetS), defined as a cluster of metabolic abnormalities including visceral adiposity, insulin resistance, hypertension, and dyslipidemia, now affects more than a third of adults in the United States highlighting the need for effective complementary approaches to current treatments.

Methods: We present a case report of a 47-year-old man with a history of MetS and poorly controlled Type 2 Diabetes Mellitus (T2D) who completed a 20Lighter program (20L) including a very low calorie diet (VLCD). At the time of enrollment his BMI was 32. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.05.036DOI Listing

Analysis of the relationship between treatment networks and the evolution of patients with Type 2 Diabetes Mellitus.

J Biomed Inform 2020 Jul 1:103497. Epub 2020 Jul 1.

Family Medicine Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

Type 2 Diabetes Mellitus (T2DM) is a chronic disease that has been increasing in prevalence in recent years and that can cause severe complications. To ensure patient care is administered correctly, it is necessary for medical treatment teams to be both multidisciplinary and cohesive. The analysis of health processes is a constant challenge due to their high variability and complexity. Read More

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http://dx.doi.org/10.1016/j.jbi.2020.103497DOI Listing

A new screening strategy and whole-exome sequencing for the early diagnosis of maturity-onset diabetes of the young.

Diabetes Metab Res Rev 2020 Jul 4:e3381. Epub 2020 Jul 4.

Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Aims: This study aimed to establish a systematic screening strategy to select candidates for genetic testing among patients with maturity-onset diabetes of the young (MODY) and to accomplish early diagnosis of MODY.

Materials And Methods: We enrolled 1478 sporadic patients from the outpatient department of Endocrinology. Out of the1478 patients, 1279 participants were successfully screened according to the "AACM" strategy, which includes the age of onset, autoantibody to islet antigen, C-peptide, and metabolic syndrome. Read More

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http://dx.doi.org/10.1002/dmrr.3381DOI Listing

Primary Care Physicians' Knowledge of the Cardiovascular Effects of Diabetes Medications: Findings from an Online Survey.

Adv Ther 2020 Jul 4. Epub 2020 Jul 4.

University of California, San Diego, CA, USA.

Introduction: Cardiovascular (CV) outcomes trial (CVOT) results have led to changes in indications for some glucose-lowering agents, with recommendations based on the presence of comorbidities.

Objective: This study aimed to understand internal medicine (IM) and family medicine (FM) physicians' knowledge of CVOTs and beliefs about type 2 diabetes mellitus (T2DM) medications, excluding insulin, for CV disease risk reduction.

Methods: WebMD, LLC, fielded a 23-item online survey from September 18 to 20, 2018, to 47,534 Medscape members (US IM and FM physicians) who were invited to participate via e-mail (quota = 500). Read More

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http://dx.doi.org/10.1007/s12325-020-01405-yDOI Listing

LEADER Trial Eligibility and Preventable Cardiovascular Events in US Adults with Diabetes: the National Health and Nutrition Examination Surveys 2007-2016.

Cardiovasc Drugs Ther 2020 Jul 3. Epub 2020 Jul 3.

Heart Disease Prevention Program, Division of Cardiology, University of California Irvine, Irvine, CA, USA.

Purpose: The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial showed the cardiovascular disease (CVD) benefits of liraglutide therapy among patients with type 2 diabetes mellitus (T2DM). We applied this trial to US adults with T2DM in terms of eligibility and preventable CVD events.

Methods: We included US adults with T2DM from the National Health and Nutrition Examination Survey (NHANES) 2007-2016. Read More

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http://dx.doi.org/10.1007/s10557-020-07032-7DOI Listing

Pancreatic ductal adenocarcinoma is associated with a unique endocrinopathy distinct from type 2 diabetes mellitus.

Pancreatology 2020 May 22. Epub 2020 May 22.

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address:

Introduction: The majority of patients with pancreatic ductal adenocarcinoma (PC) display either impaired fasting glucose/glucose intolerance or overt diabetes. However, the pathophysiologic basis of this association remains largely unexplained.

Methods: In this case-control study we aimed to study the morphological changes in the islets of patients with PC, compared to control patients with and without type 2 diabetes mellitus (T2DM). Read More

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http://dx.doi.org/10.1016/j.pan.2020.05.010DOI Listing

Burden of diabetic kidney disease among persons with type 2 diabetes mellitus registered in a tertiary care center, Puducherry.

Diabetes Metab Syndr 2020 Jun 23;14(5):991-993. Epub 2020 Jun 23.

Department of Preventive and Social Medicine, JIPMER, India. Electronic address:

Background & Aims: To determine burden of diabetic kidney disease (DKD) and estimate yield and number needed to screen (NNS) in a tertiary diabetes care center.

Methods: DKD was diagnosed if estimated Glomerular Filtration Rate (eGFR) < 60 ml/min/1.73 m or Urinary Albumin Creatinine Ratio (UACR) ≥30 mg/g in two urine samples. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.06.037DOI Listing

Metabolic and cardiovascular outcomes of bariatric surgery.

Curr Opin Lipidol 2020 Jun 28. Epub 2020 Jun 28.

Faculty of Biology, Medicine and Health, University of Manchester.

Purpose Of Review: Bariatric surgery is an effective therapy for morbid obesity that also improves weight-related metabolic parameters and reduces morbidity and mortality. The purpose of this review is to consolidate our current understanding of metabolic, macrovascular and microvascular benefits of bariatric surgery and to provide an update.

Recent Findings: Early resolution of insulin resistance and type 2 diabetes mellitus (T2DM) varies by type of bariatric surgery and appears to be mediated by changes in secretion of gut hormones, metabolism of bile acids, expression of glucose transporters and the gut microbiome. Read More

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http://dx.doi.org/10.1097/MOL.0000000000000696DOI Listing

Correction to: Design Flaws in Study of Mortality and Hospitalization After Post-Pancreatitis Diabetes Mellitus and Type 2 Diabetes Mellitus.

Am J Gastroenterol 2020 Jul;115(7):1144

Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.

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http://dx.doi.org/10.14309/ajg.0000000000000701DOI Listing

Sodium glucose co-transporter-2 inhibitors in heart failure: beyond glycaemic control. The Position Paper of the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy.

Heart failure (HF) is common and associated with a poor prognosis, despite advances in treatment. Over the last decade cardiovascular outcome trials with sodium-glucose co-transporter 2 (SGLT-2) inhibitors in patients with type 2 diabetes mellitus (T2DM) have demonstrated beneficial effects for three SGLT-2) inhibitors (empagliflozin, canagliflozin and dapagliflozin) in reducing hospitalisations for HF. More recently, dapagliflozin reduced the risk of worsening HF or death from CV causes in patients with chronic HF with reduced left ventricular ejection fraction, with or without T2DM. Read More

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http://dx.doi.org/10.1002/ejhf.1954DOI Listing

Effect of an aqueous extract of Terminalia chebula on endothelial dysfunction, systemic inflammation, and lipid profile in type 2 diabetes mellitus: A randomized double-blind, placebo-controlled clinical study.

Phytother Res 2020 Jul 2. Epub 2020 Jul 2.

Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.

Endothelial dysfunction is a crucial complication in type 2 diabetic patients, related to cardiovascular risk. Terminalia chebula (TC), a traditional ayurvedic herb, is known for its antioxidant and antihyperlipidemic activity. A prospective, randomized, double-blind, placebo-controlled clinical study was undertaken to evaluate the effects of an aqueous extract of T. Read More

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http://dx.doi.org/10.1002/ptr.6771DOI Listing

Effects of MK-7 Supplementation on Glycemic Status, Anthropometric Indices and Lipid Profile in Patients with Type 2 Diabetes: A Randomized Controlled Trial.

Diabetes Metab Syndr Obes 2020 26;13:2239-2249. Epub 2020 Jun 26.

Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Type 2 diabetes mellitus (T2DM) is a prevalent disorder which accounts for 90-95% of diabetic patients. The aim of this study was to assess the effects of menaquinone (MK-7) supplementation on glycemic indices, anthropometric indices and lipid profile, among patients with T2DM.

Methods: In this double-blind placebo-controlled randomized clinical trial, 60 men and women with T2DM were allocated equally into either the MK-7 (200 µg/day) or the placebo group. Read More

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http://dx.doi.org/10.2147/DMSO.S253014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326202PMC

Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?

Nutr Diabetes 2020 Jul 2;10(1):24. Epub 2020 Jul 2.

Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Ciudad de México, México.

Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (HFD), and high carbohydrate-high fat diet (HCHHFD). We analyzed data from at least 35 articles per diet, from different research groups, to determine their effect on the development of the MS, aimed to aid researchers in choosing the model that better suits their research question; and also the best parameter that defines obesity, as there is no consensus to determine this condition in rats. Read More

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http://dx.doi.org/10.1038/s41387-020-0127-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331639PMC

Increased Risk of Myocardial Infarction Among Patients With Type 2 Diabetes Who Carry the Common rs10830963 Variant in the Gene.

Diabetes Care 2020 Jul 2. Epub 2020 Jul 2.

Department of Neuroscience, Uppsala University, Uppsala, Sweden.

Objective: The common single nucleotide polymorphism rs10830963 associates with risk of type 2 diabetes mellitus (T2D). Here, we examine the association between this gene variant and the risk of myocardial infarction (MCI) among patients with T2D. MCI is a main cause of death and disability among such individuals. Read More

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http://dx.doi.org/10.2337/dc20-0507DOI Listing

Prediction of cardiovascular health by non-exercise estimated cardiorespiratory fitness.

Heart 2020 Jul 2. Epub 2020 Jul 2.

Cardiovascular and Nutritional Epidemiology, IMDEA-Food, Madrid, Spain.

Objective: To estimate the incidence of major biological cardiovascular disease (CVD) risk factors in adults using non-exercise estimated cardiorespiratory fitness (eCRF).

Methods: 200 039 healthy people (99 957 women), aged ≥18 years (38.5±12. Read More

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http://dx.doi.org/10.1136/heartjnl-2020-316871DOI Listing
July 2020
5.595 Impact Factor