Search our Database of Scientific Publications and Authors

I’m looking for a

    126464 results match your criteria Diabetes Mellitus Type 2

    1 OF 2530

    Breastfeeding and growth during infancy among offspring of mothers with gestational diabetes mellitus: a prospective cohort study.
    Pediatr Obes 2018 Apr 24. Epub 2018 Apr 24.
    Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
    Background: Breastfeeding (BF) may protect against obesity and type 2 diabetes mellitus in children exposed to maternal diabetes in utero, but its effects on infant growth among this high-risk group have rarely been evaluated.

    Objectives: The objective of this study was to evaluate BF intensity and duration in relation to infant growth from birth through 12 months among offspring of mothers with gestational diabetes mellitus (GDM).

    Methods: Prospective cohort of 464 GDM mother-infant dyads (28% White, 36% Hispanic, 26% Asian, 8% Black, 2% other). Read More

    Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance.
    Pediatr Diabetes 2018 Apr 25. Epub 2018 Apr 25.
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Background And Aims: A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted attention as a potential prevention or therapeutic option for obesity and type 2 diabetes mellitus (T2DM). MOTS-c profiles have not yet been reported in human obesity and T2DM. We aimed to determine circulating MOTS-c levels in obesity and explore the association between MOTS-c levels and various metabolic parameters. Read More

    Relationships between chronic comorbidities and the atherosclerosis indicators ankle-brachial index and brachial-ankle pulse wave velocity in patients with type 2 diabetes mellitus.
    J Investig Med 2018 Apr 24. Epub 2018 Apr 24.
    Department of Medicine, Mackay Medical Collage, New Taipei City, Taiwan.
    This study aimed to determine associations between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) with different comorbidities in patients with type 2 diabetes mellitus (DM). Records of patients with type 2 DM who received an ABI and baPWV examination between August 2013 and February 2015 were retrospectively reviewed. Associations of ABI and baPWV with chronic kidney disease (CKD), chronic liver disease (CLD), coronary artery disease (CAD) and diabetic nephropathy (DN) were examined by regression analysis. Read More

    Clinical assessment and treatment of diabetes in patients with chronic kidney disease.
    Rev Clin Esp 2018 Apr 21. Epub 2018 Apr 21.
    Servicio de Medicina Interna, Hospital Comarcal de Zafra, Badajoz, España.
    Diabetes mellitus type 2 is the main cause of chronic kidney disease. Patients with this disease have higher morbidity and mortality and risk of hypoglycaemia than those without this disease. In 2010, type 2 diabetes was the reason for starting renal replacement therapy in 24. Read More

    Association between Plasma Levels of PAI-1, tPA/PAI-1 Molar Ratio, and Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes Mellitus.
    J Alzheimers Dis 2018 Apr 16. Epub 2018 Apr 16.
    Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, PR China.
    Background: Plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (tPA) are involved in the complications of type 2 diabetes mellitus (T2DM) and early pathology of Alzheimer's disease.

    Objective: This study aimed to investigate the association between plasma PAI-1, tPA/PAI-1 molar ratio, and mild cognitive impairment (MCI) in Chinese T2DM patients.

    Methods: A total of 162 Chinese T2DM patients were recruited and divided into two groups according to the Montreal Cognitive Assessment score. Read More

    Increasing incidence of type 2 diabetes in New Zealand children <15 years of age in a regional-based diabetes service, Auckland, New Zealand.
    J Paediatr Child Health 2018 Apr 24. Epub 2018 Apr 24.
    Auckland District Health Board, Starship Children's Hospital, Auckland, New Zealand.
    Aim: It is important to understand whether type 2 diabetes mellitus (T2DM) is increasing in childhood for health-care planning and clinical management. The aim of this study is to examine the incidence of T2DM in New Zealand children, aged <15 years from a paediatric diabetes centre, Auckland, New Zealand.

    Methods: Retrospective analysis of prospectively collected data from a population-based referral cohort from 1995 to 2015. Read More

    The Clinical Value of Diffusion Weighted Magnetic Resonance Imaging in Diabetic Foot Infection.
    J Am Podiatr Med Assoc 2018 Apr 24. Epub 2018 Apr 24.
    ¶ Harran University.
    Background: Osteomyelitis is a common complication in the diabetic foot which can be concluded with amputation. The purpose of this study was to evaluate the role of diffusion-weighted MRI (DWI) in the diagnosis of osteomyelitis in the diabetic foot ulcer (DFU).

    Methods: Thirty patients with type 2 diabetes mellitus having DFU were enrolled. Read More

    Correlation between changes in inflammatory cytokines and the combination with hypertension in patients with type 2 diabetes mellitus.
    Minerva Endocrinol 2018 Apr 24. Epub 2018 Apr 24.
    Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing, China -
    Background: We aimed to analyze the relationship between the combination with hypertension and the level of inflammatory cytokines in peripheral serum in patients with type 2 diabetes mellitus (DM), and to explore the value of inflammatory cytokines in predicting type 2 DM combined with hypertension.

    Methods: A total of 120 patients diagnosed with type 2 DM in our hospital from March 2014 to September 2016 were selected. The clinical data were retrospectively analyzed. Read More

    Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus.
    Diabet Med 2018 Apr 23. Epub 2018 Apr 23.
    Department of Internal Medicine, University of Groningen, University Medical Centre Groningen.
    Aim: The United Kingdom Prospective Diabetes Study (UKPDS) study showed that glycaemic control (HbA ) can predict vascular complications in Type 2 diabetes mellitus. The Diabetes Control and Complications Trial (DCCT) study showed that accumulation of advanced glycation end products (AGEs) from skin biopsies predicts vascular complications in Type 1 diabetes. Previously, we showed that tissue AGEs can be measured non-invasively using skin autofluorescence (SAF). Read More

    Bone: another potential target to treat, prevent and predict diabetes.
    Diabetes Obes Metab 2018 Apr 23. Epub 2018 Apr 23.
    Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China.
    Type 2 diabetes mellitus is now a worldwide health problem with increasing prevalence. Mounting efforts have been made to treat, prevent and predict this chronic disease. In recent years, increasing evidence from mice and clinical studies suggest that bone-derived molecules modulate glucose metabolism. Read More

    Antidiabetic Effects of a Chinese Herbal Medicinal Compound Sangguayin Preparation via PI3K/Akt Signaling Pathway in Mice.
    Evid Based Complement Alternat Med 2018 4;2018:2010423. Epub 2018 Mar 4.
    Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China.
    Sangguayin (SGY), comprising four types of Chinese herbs, can be used as both food and medicine and has been clinically used to treat type 2 diabetes mellitus (T2DM) for a long time. Our previous study demonstrated the antidiabetic effect of SGY in experimental T2DM rats fed with a high-fat diet and treated with a low dose of streptozotocin. However, its mechanism of action is questionable. Read More

    Systems biology in hepatology: approaches and applications.
    Nat Rev Gastroenterol Hepatol 2018 Apr 23. Epub 2018 Apr 23.
    Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden.
    Detailed insights into the biological functions of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota can be used to develop novel strategies for the prevention and treatment of liver-associated diseases, including fatty liver disease, cirrhosis, hepatocellular carcinoma and type 2 diabetes mellitus. Biological network models, including metabolic, transcriptional regulatory, protein-protein interaction, signalling and co-expression networks, can provide a scaffold for studying the biological pathways operating in the liver in connection with disease development in a systematic manner. Here, we review studies in which biological network models were used to integrate multiomics data to advance our understanding of the pathophysiological responses of complex liver diseases. Read More

    The Effectiveness of Aerobic Exercise in Improving Peripheral Nerve Functions in Type 2 Diabetes Mellitus: An Evidence Based Case Report.
    Acta Med Indones 2018 Jan;50(1):82-87
    Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
    Background: peripheral neuropathy is known as one of most common complication in diabetes mellitus type 2 patient. This complication is caused by uncontrolled condition of blood glucose level in long periode. Regular physical activity in moderate to high intensity is beneficial in management of diabetes mellitus. Read More

    Indonesia Cohort of IO HAT Study to Evaluate Diabetes Management, Control, and Complications in Retrospective and Prospective Periods Among Insulin-Treated Patients with Type 1 and Type 2 Diabetes.
    Acta Med Indones 2018 Jan;50(1):26-37
    Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Malang, Indonesia.
    Background: hypoglycemia is a major adverse event of insulin therapy for diabetes mellitus patients. The study was conducted to evaluate the incidence of hypoglycemia among insulin treated patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) in the Indonesian cohort.

    Methods: this Indonesian cohort study consisted of retrospective and prospective evaluation of hypoglycemic episodes, using International Operations Hypoglycemia Assessment Tool (IO HAT) in 374 patients with diabetes (T1DM; n=17 or T2DM; n=357). Read More

    Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis.
    Stroke 2018 Apr 23. Epub 2018 Apr 23.
    Department of Clinical Neurosciences, Stroke Research Group, University of Cambridge, United Kingdom (J.L., L.R.-J., H.S.M., M.T.)
    Background And Purpose: The relationship between type 2 diabetes mellitus (T2D) and cerebral small vessel disease (CSVD) is unclear. We aimed to examine the causal effect of T2D, fasting glucose levels, and higher insulin resistance on CSVD using Mendelian randomization.

    Methods: Five CSVD phenotypes were studied; 2 were clinical outcomes associated with CSVD (lacunar stroke: n=2191/27 297 and intracerebral hemorrhage [ICH]: n=2254/8195 [deep and lobar ICH]), whereas 3 were radiological markers of CSVD (white matter hyperintensities: n=8429; fractional anisotropy [FA]: n=8357; and mean diffusivity: n=8357). Read More

    The benefits of yoga practice compared to physical exercise in the management of type 2 Diabetes Mellitus: A systematic review and meta-analysis.
    Diabetes Metab Syndr 2018 Apr 18. Epub 2018 Apr 18.
    Fortis-C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, Chirag Enclave, New Delhi, India, National Diabetes Obesity and Cholesterol Foundation and Diabetes Foundation, India.
    Yoga is increasingly used as an adjunctive therapy in the management of Type-2 Diabetes Mellitus (T2DM). The present study aims to systematically evaluate the literature and perform a meta-analysis on the effects of yoga practice compared to physical exercise in the management of T2DM. Data were obtained using a stepwise search process using keywords in the following online medical databases; PubMed, Web of Science and Scopus. Read More

    Validity and reliability of functional assessment of chronic illness treatment-fatigue scale in Turkish patients with type 2 diabetes.
    Endocrinol Diabetes Nutr 2018 Apr 20. Epub 2018 Apr 20.
    Hasan Kalyoncu University, Faculty of Health Science, Gaziantep, Turkey.
    Background: A long-term diabetic complication, fatigue, which is a direct result of treatment and psychological processes, is a common symptom in diabetic individuals.

    Aims: To determine the reliability and validity of Functional Assessment of Chronic Illness Treatment-Fatigue Scale in Turkish patients with type 2 diabetes.

    Study Design: A methodological study. Read More

    Association of K6.2 gene rs5219 variation with type 2 diabetes: A meta-analysis of 21,464 individuals.
    Prim Care Diabetes 2018 Apr 20. Epub 2018 Apr 20.
    Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
    Aims: rs5219 is in Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene, located at 11p15.1. Researches on the association between rs5219 gene polymorphism with type 2 diabetes mellitus (T2DM) were performed extensively, but the results remain controversial. Read More

    Insulin resistance adipocyte-derived exosomes aggravate atherosclerosis by increasing vasa vasorum angiogenesis in diabetic ApoE mice.
    Int J Cardiol 2018 Apr 9. Epub 2018 Apr 9.
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China. Electronic address:
    Background: Vasa vasorum (VV) angiogenesis is increased in type 2 diabetes mellitus (T2DM) and may promote atherosclerotic plaque rupture. We sought to determine whether insulin resistance adipocyte-derived exosomes (IRADEs) played a major role in modulating VV angiogenesis and the mechanisms involved.

    Methods: The characterization of IRADEs was performed by electron microscopy, NTA (Nanoparticle Tracking Analysis) and western blot. Read More

    Postprandial endotoxemia may influence the development of type 2 diabetes mellitus: From the CORDIOPREV study.
    Clin Nutr 2018 Apr 11. Epub 2018 Apr 11.
    Lipids and Atherosclerosis Unit, GC9 Nutrigenomics, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain. Electronic address:
    Background & Aims: Insulin resistance (IR) and impaired beta-cell function are key determinants of type 2 diabetes mellitus (T2DM). Intestinal absorption of bacterial components activates the toll-like receptors inducing inflammation, and this in turn IR. We evaluated the role of endotoxemia in promoting inflammation-induced insulin resistance (IR) in the development of T2DM, and its usefulness as predictive biomarker. Read More

    Excess Hospitalization Expenses Attributable to Type 2 Diabetes Mellitus in Singapore.
    Value Health Reg Issues 2018 Apr 20;15:106-111. Epub 2018 Apr 20.
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
    Objectives: To estimate the excess hospitalization expenses attributable to type 2 diabetes mellitus (T2DM) in a high-income Asian country from the health system perspective and the patient perspective.

    Methods: Electronic medical records from a tertiary academic hospital in Singapore from 2012 to 2013 were used to create propensity score-matched cohorts with and without T2DM on the basis of their entry characteristics. A two-part model was then used to control for remaining differences between the cohorts. Read More

    Serum fibrinogen predicts diabetic ESRD in patients with type 2 diabetes mellitus.
    Diabetes Res Clin Pract 2018 Apr 20. Epub 2018 Apr 20.
    Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address:
    Aims: Although increased serum fibrinogen level was often observed in patients with diabetic nephropathy (DN), its association with DN severity and progression remains unclear. The aim of this study was to investigate the relationship between the serum fibrinogen levels and clinicopathological features and renal prognosis in Chinese patients with type 2 diabetes mellitus (T2DM) and DN.

    Methods: A total of 174 patients with T2DM and biopsy-proven DN were enrolled. Read More

    Protective effects of sulforaphane on cognitive impairments and AD-like lesions in diabetic mice are associated with the upregulation of Nrf2 transcription activity.
    Neuroscience 2018 Apr 20. Epub 2018 Apr 20.
    Type 2 diabetes mellitus (T2DM)-associated oxidative stress contributes to cognitive deficiencies and Alzheimer's disease (AD). Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions. This study investigated the effects of SFN on DM-related cognitive decline and its potential mechanisms. Read More

    The efficacy of selected bariatric surgery methods on lipid and glucose metabolism: a retrospective 12-month study.
    Cent Eur J Public Health 2018 Mar;26(1):49-53
    Faculty of Informatics and Management, University of Hradec Králové, Hradec Králové, Czech Republic.
    Objective: Approximately 25% of the Czech population is currently obese. Obesity rates are expected to increase in the future. Obesity not only raises the risk of health complications for individuals, but increasing rates also represent a significant and steadily growing economic burden for healthcare systems and society as a whole. Read More

    Computationally identified novel agonists for GPRC6A.
    PLoS One 2018 23;13(4):e0195980. Epub 2018 Apr 23.
    Department of Medicine, University of Tennessee Health Science Center, Tennessee, United States of America.
    New insights into G protein coupled receptor regulation of glucose metabolism by β-cells, skeletal muscle and liver hepatocytes identify GPRC6A as a potential therapeutic target for treating type 2 diabetes mellitus (T2D). Activating GPRC6A with a small molecule drug represents a potential paradigm-shifting opportunity to make significant strides in regulating glucose homeostasis by simultaneously correcting multiple metabolic derangements that underlie T2D, including abnormalities in β-cell proliferation and insulin secretion and peripheral insulin resistance. Using a computational, structure-based high-throughput screening approach, we identified novel tri-phenyl compounds predicted to bind to the venus fly trap (VFT) and 7-transmembrane (7-TM) domains of GPRC6A. Read More

    ACOG Committee Opinion No. 734: The Role of Transvaginal Ultrasonography in Evaluating the Endometrium of Women With Postmenopausal Bleeding.
    • Authors:
    Obstet Gynecol 2018 May;131(5):e124-e129
    Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding. Read More

    ACOG Committee Opinion No. 734 Summary: The Role of Transvaginal Ultrasonography in Evaluating the Endometrium of Women With Postmenopausal Bleeding.
    • Authors:
    Obstet Gynecol 2018 May;131(5):945-946
    Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding. Read More

    Human Recombinant Epidermal Growth Factor in skin lesions: 77 cases in EPItelizando Project.
    J Dermatolog Treat 2018 Apr 23:1-23. Epub 2018 Apr 23.
    a Centro Médico Teknon , Barcelona , Spain.
    Objective: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series.

    Design: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. Read More

    Piperine Promotes Glucose Uptake Through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle.
    Mol Nutr Food Res 2018 Apr 23:e1800086. Epub 2018 Apr 23.
    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, 657-8501, Japan.
    Scope: The prevalence of type 2 diabetes mellitus (T2DM) is increasing yearly worldwide. Glycemic control is the basis for the treatment of T2DM, as it can prevent the progress of associated complications. Spices possess various health beneficial effects on humans. Read More

    Pioglitazone Therapy and Fractures: Systematic Review and Meta-Analysis.
    Endocr Metab Immune Disord Drug Targets 2018 Apr 23. Epub 2018 Apr 23.
    Medical University, Faculty of Pharmacy, Dean, Pleven. Bulgaria.
    Introduction: Thiazolidinediones are group of synthetic medications used in type 2 diabetes treatment. Among available thiazolidinediones pioglitazone is gaining increased attention due to its lower cardiovascular risk in type 2 diabetes mellitus sufferers and seems a promising future therapy. Accumulating evidence suggests that diabetic patients may exert bone fractures due to such treatments. Read More

    Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study.
    J Diabetes Res 2018 26;2018:5637130. Epub 2018 Feb 26.
    Unitat de Suport a la Recerca Barcelona Ciutat, Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), Universitat Autonoma de Barcelona, Bellaterra, Spain.
    Aims: To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients.

    Methods: A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Read More

    Association of MiR-146a Expression and Type 2 Diabetes Mellitus: A Meta-Analysis.
    Int J Mol Cell Med 2017 14;6(3):156-163. Epub 2017 Aug 14.
    Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Although deregulation of miR-146a has been reported in type 2 diabetes repeatedly, the direction of deregulation events (up or down) remained to be inconsistent in literatures. Therefore, in this study we performed a meta-analysis on the possible association between miR-146a expression levels and type 2 diabetes. A systematic literature searching of PubMed, ISI Web of Science and Google Scholar was performed up to the end of September 2016. Read More

    Chemerin induces endothelial cell inflammation: activation of nuclear factor-kappa beta and monocyte-endothelial adhesion.
    Oncotarget 2018 Mar 30;9(24):16678-16690. Epub 2018 Mar 30.
    Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK.
    Chemerin, a chemoattractant protein, acts a G-protein coupled chemokine receptor, Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM patients are at high risk of developing cardiovascular disorders such as atherosclerosis. We have reported that chemerin induces human endothelial cell angiogenesis and since dysregulated angiogenesis and endothelial dysfunction are hallmarks of vascular disease; we sought to determine the effects of chemerin on monocyte-endothelial adhesion, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a critical pro-inflammatory transcription factor. Read More

    Cardiovascular Disease in Japanese Patients with Type 2 Diabetes Mellitus.
    Ann Vasc Dis 2018 Mar;11(1):2-14
    Department of Internal Medicine, Niigata University Faculty of Medicine, Niigata, Niigata, Japan.
    Individuals with diabetes have a two- to four-fold increased risk of coronary artery disease (CAD) and higher mortality rates than those without diabetes. Because not only microvascular but also macrovascular disease in patients with diabetes are known to predispose patients to a lower quality of life as well as lead to higher mortality rates, identifying and managing risk factors of CAD is of clinical relevance in diabetes care. A number of antihyperglycemic drugs are currently approved for the treatment of hyperglycemia in patients with type 2 diabetes mellitus (T2DM), with several new drugs having been developed during the last decade. Read More

    The relationship between MnSOD Val16Ala gene polymorphism and the level of serum total antioxidant capacity with the risk of chronic kidney disease in type 2 diabetic patients: a nested case-control study in the Tehran lipid glucose study.
    Nutr Metab (Lond) 2018 11;15:25. Epub 2018 Apr 11.
    6Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Several studies have shown significant associations between manganese superoxide dismutase (MnSOD) Val16Ala polymorphism and diabetic complications, but this association has not been explored in relation with chronic kidney disease (CKD) in Type 2 diabetes mellitus (T2DM) patients. Total antioxidant capacity (TAC) level changes in diabetic condition and may play important role in onset or progression of the disease and its complications. The present study investigated the association of MnSOD Val16Ala polymorphism and serum TAC with the risk of CKD in T2DM patients. Read More

    Genotypic and Phenotypic Factors Influencing Drug Response in Mexican Patients With Type 2 Diabetes Mellitus.
    Front Pharmacol 2018 6;9:320. Epub 2018 Apr 6.
    Molecular Genetics Laboratory, Vitagénesis, S.A. de C.V., Monterrey, Mexico.
    The treatment of Type 2 Diabetes Mellitus (T2DM) consists primarily of oral antidiabetic drugs (OADs) that stimulate insulin secretion, such as sulfonylureas (SUs) and reduce hepatic glucose production (e.g., biguanides), among others. Read More

    Gender-specific independent and combined dose-response association of napping and night sleep duration with type 2 diabetes mellitus in rural Chinese adults: the RuralDiab study.
    Sleep Med 2018 May 7;45:106-113. Epub 2018 Feb 7.
    Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Henan, PR China. Electronic address:
    Objective: The aim of this study was to explore the independent and combined dose-response association of napping and night sleep duration with type 2 diabetes mellitus (T2DM) among different genders in the rural Chinese population.

    Methods: For this research, a total of 19,257 participants were enrolled in the Rural Diabetes, Obesity and Lifestyle (RuralDiab) study. Napping and night sleep duration were assessed using the Pittsburgh Sleep Quality Index (PSQI). Read More

    COMRADE: A randomized trial of an individually tailored integrated care intervention for uncontrolled type 2 diabetes with depression and/or distress in the rural southeastern US.
    Contemp Clin Trials 2018 Apr 19. Epub 2018 Apr 19.
    Department of Family Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, USA; Center for Health Disparities, East Carolina University, Greenville, NC, USA.
    Background: Emerging evidence suggests that people living with Type 2 diabetes mellitus (T2D) are also at greater risk for depression and distress. If left untreated, these comorbid mental health concerns can have long-lasting impacts on medical and physical health outcomes.

    Design: This prospective trial randomized rural men and women with uncontrolled T2D (HbA1c ≥ 7. Read More

    Pharmacotherapy for Hyperglycemia in Pregnancy - Do Oral Agents have a Place?
    Diabetes Res Clin Pract 2018 Apr 18. Epub 2018 Apr 18.
    Helen Schneider Hospital for Women, Rabin Medical Center, Petach-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:
    Diabetes is a frequent condition in pregnancy and achieving adequate glycemic control is of paramount importance. Insulin treatment is the gold standard, oral agents are more attractive, but their safety and efficiency should be a prerequisite for their use. We have more information regarding treatment of women with gestational diabetes mellitus where glyburide can induce a picture of fetal hyperinsulinism (higher birthweight and more neonatal hypoglycemia) whereas metformin requires supplemental insulin in a larger proportion of women but achieves satisfactory perinatal outcomes with the exception of preterm birth. Read More

    LSG vs MGB-OAGB-3 Year Follow-up Data: a Randomised Control Trial.
    Obes Surg 2018 Apr 20. Epub 2018 Apr 20.
    Department of Minimal Access & Bariatric Surgery, ILS Hospitals, DD-6, Sector 1, Salt Lake City, Kolkata, West Bengal, 700064, India.
    Aim: The objective of this study is to compare 3-year follow-up results of one anastomosis gastric bypass (MGB-OAGB) and laparoscopic sleeve gastrectomy (LSG) in terms of weight loss, complications, resolution of comorbidities and quality of life.

    Materials And Methods: A prospective randomised study of results between 100 LSG patients and 101 MGB-OAGB patients was done from 2012 to 2015. The results were compared regarding operative outcomes, percentage of excess weight loss (%EWL), complications, resolution of comorbidities and quality of life (BAROS score) at 3 years follow-up. Read More

    Bariatric Surgery in Immunocompromised Patients: Outcomes from One Year Follow-up.
    Obes Surg 2018 Apr 20. Epub 2018 Apr 20.
    Yenepoya Research Centre, Yenepoya University, University Road, Mangalore, India.
    Background: Recent Research evidences from across the world indicate the usefulness of bariatric surgery in improving the immunological co-morbidities in patients with morbid obesity.

    Aim: The aim of the study was to evaluate the outcome from bariatric surgery in patients presenting with diabetes mellitus and or morbid obesity with immunological co-morbidities.

    Methods: It was a retrospective cross-sectional study. Read More

    Metabolic Surgery and Diabesity: a Systematic Review.
    Obes Surg 2018 Apr 20. Epub 2018 Apr 20.
    Departement of Digestive Surgery, CHU Félix Guyon, Saint Denis, La Réunion, France.
    Bariatric surgery is used to induce weight loss (baros = weight). Evidence has shown that bariatric surgery improves the comorbid conditions associated with obesity such as hypertension, hyperlipidemia, and type 2 diabetes mellitus T2DM. Hence, shifting towards using metabolic surgery instead of bariatric surgery is currently more appropriate in certain subset of patients. Read More

    Do the SGLT-2 Inhibitors Offer More than Hypoglycemic Activity?
    Cardiovasc Drugs Ther 2018 Apr 20. Epub 2018 Apr 20.
    Atherothrombosis Research Unit, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, USA.
    Type 2 diabetes mellitus (T2DM) is one of the most common chronic health conditions in the USA; it affects approximately 10% of adults with up to one-quarter being undiagnosed. T2DM is associated with substantial cardiovascular (CV) morbidity and mortality. T2DM is a pathological condition characterized by elevated levels of glucose and associated with high CV risk. Read More

    The association between skin auto-fluorescence of palmoplantar sites and microvascular complications in Asian patients with type 2 diabetes mellitus.
    Sci Rep 2018 Apr 20;8(1):6309. Epub 2018 Apr 20.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Skin auto-fluorescence (SAF) has generated broad interest about the prospects for non-invasive advanced glycation end product assessment and its direct interplay with the development of microvascular complications, but clinical application of the existing SAF measuring of non-palmoplantar sites in non-Caucasian subjects with dark skin type is still controversial. Here, we tested the diabetic complication screening performance of a novel SAF measuring system in Asian type 2 diabetes mellitus (T2DM) subjects. A total of 166 Korean patients with T2DM were enrolled in this study and palmoplantar SAF was measured by a newly developed transmission-geometry noninvasive optical system. Read More

    Hypoglycemia in Type 2 DM patients: Review article.
    Diabetes Metab Syndr 2018 Apr 12. Epub 2018 Apr 12.
    Family and Community Medicine Department, Chronic Diseases Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
    Hypoglycemia is an essential issue for diabetic patients and considered a limiting factor in the glycemic management. Heterogeneity of the diseases in Type 2 Diabetes Mellitus can affect the frequency of hypoglycemia, especially when the patient has cardiovascular diseases. There are several factors lead to hypoglycemia sulfonylurea therapy, insulin therapy, delayed or missed a meal, physical exercise, or drug or alcohol consumption. Read More

    Behavioral and familial predictors of diabetes mellitus in adults aged 20-69 in Yazd, Iran during 2014-2015.
    Diabetes Metab Syndr 2018 Apr 11. Epub 2018 Apr 11.
    Department of Endocrinology, Faculty of Medicine, Shahid Sadoughi University, Yazd, Iran.
    Introduction: The present study aimed to assess the behavioral and familial predictors of diabetes mellitus as well as their interaction in the risk of diabetes mellitus type2.

    Methods: The present cross-sectional study was conducted using the Yazd health study (YaHS) data which was collected in 2013-14. Statistical population of this study consisted of all 9340 individuals aged between 20 and 69 in Yazd City. Read More

    G-protein-coupled receptors (GPCRs) in the treatment of diabetes: Current view and future perspectives.
    Best Pract Res Clin Endocrinol Metab 2018 Apr 15;32(2):201-213. Epub 2018 Mar 15.
    Department of Medicine, Surgery and Neurosciences, University of Siena, Italy; Fondazione Umberto Di Mario ONLUS c/o Toscana Life Science, Siena, Italy. Electronic address:
    G-protein coupled receptors (GPCRs) represent the largest receptor family in the genome and are of great interest for the design of novel drugs in a wide variety of diseases including neurologic disorders, obesity and Type 2 diabetes mellitus. The latter is a chronic disease characterized by insulin resistance and impaired insulin secretion, affecting >400 million patients worldwide. Here we provide an overview on: a) The molecular basis of GPCR signalling and of its involvement in the regulation of insulin secretion and of glucose homeostasis; b) the role of GPCRs in type 2 diabetes pathophysiology and as therapeutic targets of current and future glucose-lowering drugs. Read More

    Proresolving protein Annexin A1: The role in type 2 diabetes mellitus and obesity.
    Biomed Pharmacother 2018 Apr 17;103:482-489. Epub 2018 Apr 17.
    Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
    Background: Annexin A1 (AnxA1) is a protein involved in inflammation resolution that might be altered in obesity-associated type 2 diabetes mellitus (DM), which is a chronic inflammatory disease. The aim of this study was to evaluate AnxA1 serum levels in individuals with and without DM stratified according to the body mass index (BMI), and the dynamic of AnxA1 expression in adipose tissue from humans with obesity and non-obesity.

    Methods: Serum samples were obtained from 41 patients with DM (lean, overweight and obese) and 40 controls, and adipose tissue samples were obtained from 16 individuals with obesity (with or without DM), and 15 controls. Read More

    Characteristics of Retinal Structural and Microvascular Alterations in Early Type 2 Diabetic Patients.
    Invest Ophthalmol Vis Sci 2018 Apr;59(5):2110-2118
    School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
    Purpose: To investigate early retinal structural and microvascular changes in patients with type 2 diabetes mellitus (DM) and to analyze relationships among the retinal structure, microvasculature, and choroid.

    Methods: Seventy-seven patients with type 2 DM (40 with no diabetic retinopathy [DR], 37 with nonproliferative diabetic retinopathy [NPDR]), and 34 control subjects were enrolled. Spectral-domain optical coherence tomography, operating in radial 18-line mode, obtained macular images of the eight intraretinal layers and the choroid. Read More

    Behavioral, morphological and electrophysiological assessment of the effects of type 2 diabetes mellitus on large and small nerve fibers in Zucker diabetic fatty rat, Zucker lean and Wistar rats.
    Eur J Pain 2018 Apr 20. Epub 2018 Apr 20.
    Boehringer Ingelheim Pharma GmbH& Co. KG, Biberach an der Riss, Germany.
    Background: Peripheral neuropathy is a common complication in type 2 diabetes mellitus (T2DM). The most common presentation is in the form of a distal axonal sensory-motor polyneuropathy that involves large and small nerve fibers in variable proportion.

    Methods: Zucker Diabetic Fatty rats (ZDF), Zucker Lean (ZL) and Wistar Han (WH) rats were used to asses the behavioral, morphological and electrophysiological effects that T2DM have on peripheral large and small nerve fibers of 6-40 week-old rats. Read More

    1 OF 2530