135,868 results match your criteria Diabetes Mellitus Type 2


Association between phthalate exposure and glycosylated hemoglobin, fasting glucose, and type 2 diabetes mellitus: A case-control study in China.

Sci Total Environ 2019 Mar 14;670:41-49. Epub 2019 Mar 14.

Metabolic Disease Hospital, Tianjin Medical University, Tianjin, China.

Epidemiological studies have shown that exposure to phthalates (PAEs) is associated with type 2 diabetes mellitus (T2DM) and related markers, but limited evidence has been found in Chinese people. Given that China has the highest number of people with DM and Chinese people show relatively higher exposure levels of PAEs, a case-control study was conducted in China to explore the associations of PAE exposure with T2DM and two glycemic indicators, including fasting glucose and glycosylated hemoglobin (HbA1c). Two hundred fifty people with T2DM and 250 controls were recruited in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2019.03.192DOI Listing

Sweetening the Therapeutic Pot for Type 2 Diabetes with Long Noncoding RNAs.

Cell Chem Biol 2019 Mar;26(3):311-313

Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA. Electronic address:

Long noncoding RNAs (lncRNAs) have emerged as essential cellular regulators and potential disease targets. In this issue of Cell Chemical Biology, Shi et al. (2019) identify a cyclic peptide that results in restored glucose processing in type 2 diabetes mellitus (T2DM) patient derived adipocytes through stabilization of lncRNA GAS5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2019.02.022DOI Listing

Non-alcoholic fatty pancreas disease - practices for clinicians.

Rom J Intern Med 2019 Jan 1. Epub 2019 Jan 1.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Obesity is a growing health burden worldwide, increasing the risk for several diseases featuring the metabolic syndrome - type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease and cardiovascular diseases. With the increasing epidemic of obesity, a new pathologic condition has emerged as a component of the metabolic syndrome - that of non-alcoholic fatty pancreas disease (NAFPD). Similar to non-alcoholic fatty liver disease (NAFLD), NAFPD comprises a wide spectrum of disease - from deposition of fat in the pancreas -fatty pancreas, to pancreatic inflammation and possibly pancreatic fibrosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/rjim-2019-0005DOI Listing
January 2019

Liraglutide Exerts an Anti-Inflammatory Action in Obese Patients with Type 2 Diabetes.

Rom J Intern Med 2019 Jan 1. Epub 2019 Jan 1.

Department of Internal Medicine No.3 with Phthisiology, Ukrainian Medical Stomatological Academy, Shevchenko Str., Poltava, Ukraine.

Introduction: Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify a level of inflammatory biomarkers. L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin 1(SIRT1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/rjim-2019-0003DOI Listing
January 2019

Interaction of antioxidant gene variants and susceptibility to Type 2 Diabetes Mellitus.

Br J Biomed Sci 2019 Mar 22. Epub 2019 Mar 22.

c Department of Physiology , King George's Medical University , Lucknow , Uttar Pradesh , India - 226003.

Background: Diabetes is the seventh most common disease leading to death with a global estimate of 425 million diabetics, which is expected to be 629 million in 2045. The role of reactive metabolites and antioxidants, such as glutathione, glutathione peroxidase, superoxide dismutase and catalase in type 2 diabetes mellitus (T2DM) provides an opportunity for identifying gene variants and risk genotypes. We hypothesised that certain antioxidant gene-gene interactions are linked to susceptibility to T2DM and so can model disease risk prediction. Read More

View Article

Download full-text PDF

Source

Gingival crevicular fluid resistin levels in chronic periodontitis with type 2 diabetes before and after non-surgical periodontal therapy: A clinico-biochemical study.

Indian J Dent Res 2019 Jan-Feb;30(1):47-51

Department of Periodontics, Oxford Dental College, Bengaluru, Karnataka, India.

Aim: Periodontitis and diabetes mellitus share a bidirectional relationship. Resistin is an adipocytokine shown to be associated with type 2 diabetes mellitus. Hence, the present study aims to estimate the effect of non-surgical periodontal therapy (NSPT) on GCF resistin levels in healthy individuals with gingivitis and well controlled diabetics with periodontitis, and correlate the same with HbA1c levels of the diabetic subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijdr.IJDR_215_17DOI Listing

The association of calcium channel blockers with β-cell function in type 2 diabetic patients: A cross-sectional study.

J Clin Hypertens (Greenwich) 2019 Mar 22. Epub 2019 Mar 22.

Beijing Key Laboratory of Diabetes Prevention and Research, Endocrinology Center, Capital Medical University, Beijing Luhe hospital, Beijing, China.

Type 2 diabetes mellitus (T2DM) patients are often accompanied with hypertension. However, the association of antihypertensive drugs with β-cell function has not been well studied. To investigate this question, the authors performed a cross-sectional study involving 882 hypertensive T2DM patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jch.13517DOI Listing

A Propensity Score Matched Comparison of Brand and Biosimilar Basal Insulin in Non-Critical Hospitalized Patients with Type 2 Diabetes Mellitus.

Adv Ther 2019 Mar 21. Epub 2019 Mar 21.

Qingdao Endocrine and Diabetes Hospital, Fuzhou Road 81, Qingdao, 266071, China.

Introduction: Comparisons between brand and biosimilar basal insulin in hospitalized patients are lacking. We aimed to compare the efficacy and safety of brand insulin glargine vs. biosimilar insulin glargine in non-critical hospitalized patients with type 2 diabetes mellitus (T2DM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12325-019-00922-9DOI Listing

Choroidal thickness changes following cataract surgery in patients with type 2 diabetes mellitus.

J Curr Ophthalmol 2019 Mar 11;31(1):49-54. Epub 2018 Aug 11.

Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the choroidal thickness changes after cataract surgery in type 2 diabetic patients.

Methods: Three groups of patients were enrolled into this prospective study. Group A included diabetic patients without diabetic retinopathy (DR) or with mild non-proliferative diabetic retinopathy (NPDR) who underwent phacoemulsification, Group B included non-diabetic patients with significant cataract who underwent phacoemulsification, and Group C included diabetic patients without DR or with mild NPDR who followed up without surgical procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joco.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407067PMC

Gestational diabetes mellitus and macrosomia predispose to diabetes in the Lebanese population.

J Clin Transl Endocrinol 2019 Jun 20;16:100185. Epub 2019 Feb 20.

School of Medicine, Lebanese American University, Beirut, Lebanon.

Aims: The Middle East has the fastest rising rate of Type 2 Diabetes Mellitus (T2DM) worldwide, with Lebanon having 15.8% of its population affected. This study aims at studying Polycystic Ovarian Syndrome (PCOS), Gestational Diabetes Mellitus (GDM), and macrosomia as risk factors of T2DM in Lebanon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcte.2019.100185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406007PMC

Serum free thiols in type 2 diabetes mellitus: A prospective study.

J Clin Transl Endocrinol 2019 Jun 28;16:100182. Epub 2019 Feb 28.

Isala, Diabetes Centre, Zwolle, the Netherlands.

Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcte.2019.100182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407140PMC

Validity of ICD-10-CM codes for determination of diabetes type for persons with youth-onset type 1 and type 2 diabetes.

BMJ Open Diabetes Res Care 2019 16;7(1):e000547. Epub 2019 Feb 16.

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.

Objective: Diagnosis codes might be used for diabetes surveillance if they accurately distinguish diabetes type. We assessed the validity of (ICD-10-CM) codes to discriminate between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) among health plan members with youth-onset (diagnosis age <20 years) diabetes.

Research Design And Methods: Diabetes case identification and abstraction of diabetes type was done as part of the SEARCH for Diabetes in Youth Study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjdrc-2018-000547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398816PMC
February 2019
1 Read

Emphysematous cystitis in an elderly Japanese patient with type 2 diabetes mellitus.

Clin Case Rep 2019 Mar 6;7(3):585-586. Epub 2019 Feb 6.

Department of Medicine, Division of Diabetes, Metabolism and Endocrinology Showa University School of Medicine Tokyo Japan.

We report a rare but fatal case of emphysematous cystitis (EC) that presented as a typical image of gas bubbles within the urinary bladder wall on computed tomography (CT). This disease has a high mortality rate more than that reported previously based on recent literature review in Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.2028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406141PMC

Comparison of the incidence of new malignancies in diabetic patients in urban and rural populations in Poland in the years 2008-2014 based on the database of the National Health Fund.

Arch Med Sci 2019 Mar 5;15(2):330-336. Epub 2017 Oct 5.

Department of Health Care, Center of Postgraduate Medical Education, Warsaw, Poland.

Introduction: Many epidemiological studies show a correlation between the risk of cancer and type 2 diabetes mellitus in various populations.

Material And Methods: The material was obtained from the database of the National Health Fund. This publication presents a comparison of the incidence of new malignancies in rural and urban populations of diabetic patients in Poland based on the database of the National Health Fund for the period between 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/aoms.2017.68409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425219PMC

The effect of the Chinese Famine on type 2 diabetes mellitus epidemics.

Nat Rev Endocrinol 2019 Mar 21. Epub 2019 Mar 21.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41574-019-0195-5DOI Listing

The effect of type 2 diabetes mellitus and obesity on muscle progenitor cell function.

Stem Cell Res Ther 2019 Mar 21;10(1):103. Epub 2019 Mar 21.

The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, People's Republic of China.

In addition to its primary function to provide movement and maintain posture, the skeletal muscle plays important roles in energy and glucose metabolism. In healthy humans, skeletal muscle is the major site for postprandial glucose uptake and impairment of this process contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). A key component to the maintenance of skeletal muscle integrity and plasticity is the presence of muscle progenitor cells, including satellite cells, fibroadipogenic progenitors, and some interstitial progenitor cells associated with vessels (myo-endothelial cells, pericytes, and mesoangioblasts). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13287-019-1186-0DOI Listing

Partial magnetic jejunal diversion (PMJD) in severely obese patients.

Rozhl Chir Winter 2019;98(2):71-76

Most patients with type 2 diabetes mellitus suffer from obesity. Studies show that surgical intervention is a suitable method for the improvement or remission of type 2 diabetes mellitus. However, a very small percentage of the total number of obese patients (diabetics in addition) undergo surgery. Read More

View Article

Download full-text PDF

Source

Bariatric/metabolic surgery: the diabetologists view.

Authors:
M Haluzík

Rozhl Chir Winter 2019;98(2):46-51

Bariatric surgery is a traditional method used for the treatment of higher degrees of obesity. Emerging evidence suggests that it also represents a very efficacious approach to the treatment of metabolic complications of obesity, in particular type 2 diabetes mellitus. In this paper, we summarize the results of the studies exploring the influence of bariatric surgery on the metabolic complications of obesity and discuss possible mecha-nism behind the improvements or remission of diabetes after bariatric surgery. Read More

View Article

Download full-text PDF

Source

Intermittent Fasting in Cardiovascular Disorders-An Overview.

Nutrients 2019 Mar 20;11(3). Epub 2019 Mar 20.

Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.

Intermittent fasting is a form of time restricted eating (typically 16 h fasting and 8 h eating), which has gained popularity in recent years and shows promise as a possible new paradigm in the approach to weight loss and the reduction of inflammation, and has many potential long term health benefits. In this review, the authors will incorporate many aspects of fasting, mainly focusing on its effects on the cardiovascular system, involving atherosclerosis progression, benefits for diabetes mellitus type 2, lowering of blood pressure, and exploring other cardiovascular risk factors (such as lipid profile and inflammation). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11030673DOI Listing

Zinc alpha 2 glycoprotein as an early biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus.

J Bras Nefrol 2019 Mar 18. Epub 2019 Mar 18.

Faculty of Medicine, Clinical Pathology Department, Zagazig University, Egypt.

Introduction: Although microalbuminuria remains the gold standard for early detection of diabetic nephropathy (DN), it is not a sufficiently accurate predictor of DN risk. Thus, new biomarkers that would help to predict DN risk earlier and possibly prevent the occurrence of end-stage kidney disease are being investigated.

Objective: To investigate the role of zinc-alpha-2-glycoprotein (ZAG) as an early marker of DN in type 2 diabetic (T2DM) patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2175-8239-JBN-2018-0200DOI Listing
March 2019
1 Read

Poor risk factor control in outpatients with diabetes mellitus type 2 in Germany: The DIAbetes COhoRtE (DIACORE) study.

PLoS One 2019 21;14(3):e0213157. Epub 2019 Mar 21.

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.

Introduction: Patients with diabetes mellitus type 2 (DM2) are at high risk for micro- and macrovascular disease. Here, we explore the degree of traditional risk factor control in the baseline visit of a cohort of DM2 outpatients.

Methods: DIACORE (DIAbetes COhoRtE) is a prospective cohort study of 3000 adult DM2 outpatients. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213157PLOS

Association Between Age at Natural Menopause and Risk of Type 2 Diabetes in Postmenopausal Obese and Non-Obese Females.

J Clin Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China.

Purpose: The relationship between age at natural menopause and type 2 diabetes mellitus (T2DM) has yielded conflicting results, particularly when confounded by the presence of obesity. We therefore aimed to examine the association between age at natural menopause and development of T2DM, and the influence of postmenopausal obese status on this association.

Methods: The data for this study was derived from one center (Beijing) of the REACTION study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02310DOI Listing
March 2019
1 Read

White Blood Cell Count and C-Reactive Protein Independently Predicted Incident Diabetes: Yuport Medical Checkup Center Study.

Endocr Res 2019 Mar 21:1-11. Epub 2019 Mar 21.

d Akimoto Occupational Health Consultant Office , Tokyo Japan.

Aim: White blood cell (WBC) count or C-reactive protein (CRP) level alone may not fully indicate the chronic inflammation causing type 2 diabetes. We examined both WBC count and CRP level, independently and in combination, as predictive markers for type 2 diabetes and also considered the influence of obesity and other individual characteristics on the relationship.

Materials And Methods: In total, 9,706 participants were enrolled with WBC < 10*10/L and CRP < 10 mg/L using data from the Yuport Medical Checkup Center Study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07435800.2019.1589494DOI Listing

A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF).

Eur J Heart Fail 2019 Mar 21. Epub 2019 Mar 21.

Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.

Background: Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been shown to reduce the risk of incident heart failure hospitalization in individuals with type 2 diabetes who have, or are at high risk of, cardiovascular disease. Most patients in these trials did not have heart failure at baseline and the effect of SGLT2 inhibitors on outcomes in individuals with established heart failure (with or without diabetes) is unknown.

Design And Methods: The Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure trial (DAPA-HF) is an international, multicentre, parallel group, randomized, double-blind, study in patients with chronic heart failure, evaluating the effect of dapagliflozin 10 mg, compared with placebo, given once daily, in addition to standard care, on the primary composite outcome of a worsening heart failure event (hospitalization or equivalent event, i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ejhf.1432DOI Listing
March 2019
1 Read

The Effect of Puguntano Leaf Extract (.) On P38 Mapk Levels and Glut-4 Expression in Type 2 Diabetic Rat Muscle.

Open Access Maced J Med Sci 2019 Feb 26;7(4):521-525. Epub 2019 Feb 26.

Department of Biostatistics, Faculty of Public Health, University of Sumatera Utara, Medan, Indonesia.

Background: Puguntano (.) contains flavonoids, saponins, tannins, and steroids/ terpenoids which improved post-receptor insulin signalling in rats model of type 2 diabetes mellitus (T2DM).

Aim: This study aimed to determine the effect of puguntano leaf extract on p38 mitogen-activated protein kinase (MAPK) levels and glucose transporter-4 (GLUT-4) expression in diabetic rats muscle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3889/oamjms.2019.165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420951PMC
February 2019

In vitro micro-physiological model of the inflamed human adipose tissue for immune-metabolic analysis in type II diabetes.

Sci Rep 2019 Mar 20;9(1):4887. Epub 2019 Mar 20.

Institute of Microelectronics, Agency for Science Technology and Research (A*STAR), 2 Fusionopolis Way, #08-02, Innovis, Singapore, 138634, Singapore.

Chronic inflammation mediated by the interaction of immune cells and adipocytes is a key underlying factor in obesity-associated type 2 diabetes mellitus (T2DM). Therefore, methods to investigate adipocyte-immune cells interaction and their immuno-metabolic status in obese/T2DM subjects not only serve as an early indicator of disease development but also provide an insight into disease mechanism. A microfluidic-based in vitro model of the human adipose that is interfaced with a co-culture of immune cell has been developed for in vitro immune-metabolic analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-41338-3DOI Listing
March 2019
1 Read

Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes.

J Transl Med 2019 Mar 20;17(1):95. Epub 2019 Mar 20.

Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Campus Universitario de Teatinos, s/n., Malaga, Spain.

Background: Oxidized low-density lipoproteins and scavenger receptors (SRs) play an important role in the formation and development of atherosclerotic plaques. However, little is known about their presence in epicardial adipose tissue (EAT). The objective of the study was to evaluate the mRNA expression of different SRs in EAT of patients with ischemic heart disease (IHD), stratifying by diabetes status and its association with clinical and biochemical variables. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12967-019-1842-2DOI Listing
March 2019
1 Read

Metformin treatment improves the spatial memory of the aged mice in an APOE genotype-dependent manner.

FASEB J 2019 Mar 20:fj201802718R. Epub 2019 Mar 20.

Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, China.

Aging and apolipoprotein E4 (ApoE4) can increase the risk of cognitive impairment and neurodegenerative disorders, including Alzheimer's disease (AD), and patients with type 2 diabetes mellitus are highly susceptible to cognitive dysfunction. Recent research has indicated that metformin, a prescribed drug for type 2 diabetes, may affect cognitive function; however, findings regarding its efficacy are largely controversial. The current study reported that a 5-mo metformin administration (300 mg/kg/d) starting at 13 mo old improved the spatial memory of ApoE3-target replacement (TR) mice, not ApoE4-TR mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201802718RDOI Listing

Pancreatic Blood Flow with Special Emphasis on Blood Perfusion of the Islets of Langerhans.

Compr Physiol 2019 Mar 14;9(2):799-837. Epub 2019 Mar 14.

Uppsala University, Department of Medical Cell Biology, Uppsala, Sweden.

The pancreatic islets are more richly vascularized than the exocrine pancreas, and possess a 5- to 10-fold higher basal and stimulated blood flow, which is separately regulated. This is reflected in the vascular anatomy of the pancreas where islets have separate arterioles. There is also an insulo-acinar portal system, where numerous venules connect each islet to the acinar capillaries. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/cphy.c160050
Publisher Site
http://dx.doi.org/10.1002/cphy.c160050DOI Listing
March 2019
3 Reads

Use of sodium-glucose cotransporter-2 inhibitors and urinary tract infections in type 2 diabetes patients: a systematic review.

Rev Assoc Med Bras (1992) 2019 Feb;65(2):246-252

Coordinator of the Medical Clinic Internship of the Graduate program in Medicine, Catholic University of Brasília, Brasília (DF), Brasil.

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are drugs that act by maintaining glycosuria. Recent studies have shown promising effects of these in the treatment of type 2 diabetes mellitus (DM2). However, there may be an increased risk of developing urinary tract infections (UTIs) in patients treated with these. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1806-9282.65.2.246DOI Listing
February 2019
1 Read

Erratum: Periodontal parameters in prediabetes, type 2 diabetes mellitus, and non-diabetic patients. Braz Oral Res. 2018;32:e81. https://doi.org/10.1590/1807-3107bor-2018.vol32.0081.

Authors:

Braz Oral Res 2019 03 18;32:e81err. Epub 2019 Mar 18.

[This corrects the article doi: 10.1590/1807-3107bor-2018.vol32. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1807-3107bor-2018.vol32.0081errDOI Listing
March 2019
2 Reads

Management of Diabetes Mellitus in Adults at the End of Life: A Review of Recent Literature and Guidelines.

J Palliat Med 2019 Mar 20. Epub 2019 Mar 20.

2 Department of Palliative Care, Bruyère Continuing Care, Ottawa, Ontario, Canada.

Background: The prevalence of diabetes mellitus (DM) is rising with an increased risk of developing it as a person ages. Therefore, more persons will have comorbid DM throughout their health journey and are potentially prone to unpleasant symptoms associated with poor glycemic control at the end of life (EOL). We performed an in-depth literature review to examine evidence-based recommendations on DM management at the EOL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jpm.2018.0614DOI Listing
March 2019
2 Reads

Comparative medical characteristics of ZDF-T2DM rats during the course of development to late stage disease.

Animal Model Exp Med 2018 Sep 25;1(3):203-211. Epub 2018 Sep 25.

Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming China.

Background: There are few reports on the comparative medical characteristics of type 2 diabetes models in late stage. An analysis of comparative medical characteristics of Zucker diabetic fatty type 2 diabetes mellitus (ZDF-T2DM) rats during the course of development to late stage disease was performed.

Methods: In this study, ZDF rats were fed with high-sugar and high-fat diets to raise the fasting blood glucose, and develop of type 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ame2.12030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388085PMC
September 2018
1 Read

Activation of cancer-related and mitogen-activated protein kinase signaling pathways in human mature osteoblasts isolated from patients with type 2 diabetes.

Bone Rep 2019 Jun 21;10:100199. Epub 2019 Feb 21.

Department of Orthopaedic and Spinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

Diabetes mellitus is a disease of glucose metabolism, and it adversely affects bone metabolism and increases the risk of cancer development. Previously, we reported a method for the direct isolation of human mature osteoblasts and indicated that osteoblasts were associated with type 2 diabetes mellitus-related signaling pathways. In addition, a recent report suggested that osteoblasts are involved in glucose metabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bonr.2019.100199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406057PMC
June 2019
1 Read

Werner's Syndrome: Understanding the Phenotype of Premature Aging-First Case Described in Colombia.

Case Rep Genet 2019 12;2019:8538325. Epub 2019 Feb 12.

Human Genetics Institute, School of Medicine, Pontifical Xavierian University, Bogotá, Colombia.

Werner's syndrome (WS) is an autosomal recessive genetic disease, which is mainly characterized by scleroderma-like skin changes, juvenile cataracts, short stature, and signs of premature aging. We report a case of a 48-year-old male patient, who presents with cardinal signs of WS including high-pitched voice, sclerotic skin lesions mainly on feet, premature greying of scalp hair, bilateral cataracts, and "bird-like" facial appearance. In addition, the patient presents other clinical characteristics observed in patients with WS such as short stature, type 2 diabetes mellitus, hypogonadism, parental consanguinity, and a history of a sibling with similar clinical characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/8538325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390251PMC
February 2019
6 Reads

Lifestyle intervention programme for Indian women with history of gestational diabetes mellitus.

Glob Health Epidemiol Genom 2019 11;4:e1. Epub 2019 Mar 11.

Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.

Aim: To evaluate the feasibility and potential effectiveness of a lifestyle intervention (diet and physical activity) among women with history of gestational diabetes mellitus (GDM), delivered by trained facilitators.

Methods: Fifty-six normoglycaemic or prediabetic women with prior GDM were recruited at mean of 17 months postpartum. Socio-demographic, medical and anthropometric data were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/gheg.2018.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415123PMC

Prevalence and associated factors of hospitalization for dysglycemia among elderly type 2 diabetes patients: A nationwide study.

World J Diabetes 2019 Mar;10(3):212-223

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, United States.

Background: The prevalence of older individuals with type 2 diabetes mellitus (T2DM) is increasing due to the aging population and improved medical care. These patients are very susceptible to disease and treatment-related hospitalizations, resulting in higher health care costs, morbidity, and decreased quality of life. However, data of treatment-related complications, especially dysglycemia-related hospitalizations, are lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4239/wjd.v10.i3.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422861PMC
March 2019
6 Reads

Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron.

World J Diabetes 2019 Mar;10(3):169-180

Andreas Melidonis 1 Department of Internal Medicine and Diabetes Center, Tzaneio General Hospital of Piraeus, Athens 18536, Greece.

The detrimental effects of constant hyperglycemia on neural function have been quantitatively and qualitatively evaluated in the setting of diabetes mellitus. Some of the hallmark features of diabetic encephalopathy (DE) are impaired synaptic adaptation and diminished spatial learning capacity. Chronic and progressive cognitive dysfunction, perpetuated by several positive feedback mechanisms in diabetic subjects, facilitates the development of early-onset dementia and Alzheimer's disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4239/wjd.v10.i3.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422855PMC
March 2019
1 Read

Exposing the Causal Effect of Body Mass Index on the Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study.

Front Genet 2019 14;10:94. Epub 2019 Feb 14.

School of Life Sciences and Technology, Harbin Institute of Technology, Harbin, China.

High body mass index (BMI) is a positive associated phenotype of type 2 diabetes mellitus (T2DM). Abundant studies have observed this from a clinical perspective. Since the rapid increase in a large number of genetic variants from the genome-wide association studies (GWAS), common SNPs of BMI and T2DM were identified as the genetic basis for understanding their associations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2019.00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413727PMC
February 2019
1 Read

Cardiovascular disease risk factors in Pakistani population with newly diagnosed Type 2 diabetes mellitus: A cross-sectional study of selected family practitioner clinics in four provinces of Pakistan (CardiP Study).

J Pak Med Assoc 2019 Mar;69(3):306-312

Aga Khan University Hospital, Karachi, Pakistan.

Objective: To explore cardiovascular risk factors in people with newly-diagnosed type 2 diabetes mellitus.

Methods: The cross-sectional, prospective, multicentre, study was conducted from June 2014 till July 2015 at family practice clinics in 27 cities across Pakistan, and comprised individuals aged 30-50 years diagnosed with type 2 diabetes mellitus within the preceding six months. Laboratory investigations were conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, and Aga Khan University Hospital, Karachi. Read More

View Article

Download full-text PDF

Source

Rates of Cardiac Rhythm Abnormalities in Patients with CKD and Diabetes.

Clin J Am Soc Nephrol 2019 Mar 19. Epub 2019 Mar 19.

Kidney Research Institute.

Background And Objectives: Cardiac arrhythmias increase mortality and morbidity in CKD. We evaluated the rates of subclinical arrhythmias in a population with type 2 diabetes and patients with moderate to severe CKD who were not on dialysis.

Design, Setting, Participants & Measurements: This is a prospective observational study, using continuous ambulatory cardiac monitors to determine the rate of atrial and ventricular arrhythmias, as well as conduction abnormalities in this group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2215/CJN.09420818DOI Listing
March 2019
1 Read

A polymorphism rs6815464 in the macrophage erythroblast attacher gene is associated with low bone mineral density in postmenopausal Japanese women.

Gene 2019 Mar 16;700:1-6. Epub 2019 Mar 16.

Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background And Purposes: Osteoporosis and osteopenia are multifactorial diseases characterized by low bone mineral density (BMD) and are susceptible to genetic and environmental risk factors. The macrophage erythroblast attacher (MAEA) was discovered as a protein to mediate the attachment of erythroid cells to macrophages and is essential for bone marrow hematopoiesis. MAEA is expressed in a wide range of cells and tissues including osteoblasts and osteoclasts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.03.027DOI Listing
March 2019
1 Read

ε3/4 genotype of the apolipoprotein E is associated with higher risk of Alzheimer's disease in patients with type 2 diabetes mellitus.

Gene 2019 Mar 16. Epub 2019 Mar 16.

Center of Diabetes Mellitus, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, PR China. Electronic address:

As a progressive and chronic disease, type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia with rising prevalence worldwide. The ε4 allele of the apolipoprotein E (ApoE) gene may be risk factor of severe peripheral neuropathy in T2DM patients. The association of ApoE polymorphism and Alzheimer's disease (AD) in T2DM patients remains largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.03.024DOI Listing

Factors influencing self-management in patients with type 2 diabetes in general practice: a qualitative study.

Aust J Prim Health 2019 Mar 20. Epub 2019 Mar 20.

Many Australian adults with type 2 diabetes mellitus (T2DM) do not follow recommended self-management behaviours that could prevent or delay complications. This exploratory study aimed to investigate the factors influencing self-management of T2DM in general practice. Semi-structured qualitative interviews were conducted with patients with T2DM (n = 10) and their GPs (n = 4) and practice nurses (n = 3) in a low socioeconomic area of Sydney, New South Wales, Australia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1071/PY18095DOI Listing

Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study.

Cardiovasc Diabetol 2019 Mar 19;18(1):36. Epub 2019 Mar 19.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #10 63-ro, Yeongdeungpo-gu, Seoul, 07345, South Korea.

Background: Because weight control is a cornerstone of diabetes management, it is important to understand the relationship of weight change to risk of cardiovascular disease (CVD) among patients with type 2 diabetes mellitus (DM). We aimed to investigate whether changes in weight early after diagnosis influence the incidence of CVD and all-cause mortality in patients with type 2 DM.

Methods: Using nationally representative data from the Korean National Health Insurance System, 173,246 subjects with new-onset DM who underwent health examinations during 2007-2012 were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12933-019-0838-9DOI Listing

Mediterranean Diet and Cardiodiabesity: A Systematic Review through Evidence-Based Answers to Key Clinical Questions.

Nutrients 2019 Mar 18;11(3). Epub 2019 Mar 18.

FoodLab Research Group (2017SGR 83), Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), 08018 Barcelona, Spain.

The Mediterranean Diet (MedDiet) has been promoted as a means of preventing and treating cardiodiabesity. The aim of this study was to answer a number of key clinical questions (CQs) about the role of the MedDiet in cardiodiabesity in order to provide a framework for the development of clinical practice guidelines. A systematic review was conducted to answer five CQs formulated using the Patient, Intervention, Comparison, and Outcome (PICO) criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu11030655DOI Listing
March 2019
1 Read

Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling.

Authors:
Krasimir Kostov

Int J Mol Sci 2019 Mar 18;20(6). Epub 2019 Mar 18.

Department of Pathophysiology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.

Magnesium (Mg) is an essential mineral for human health and plays an important role in the regulation of glucose homeostasis and insulin actions. Despite the widespread clinical evidences for the association of Mg deficiency (MgD) and type 2 diabetes mellitus (T2D), molecular mechanisms by which Mg contributes to insulin resistance (IR) are still under discussion. Mg regulates electrical activity and insulin secretion in pancreatic beta-cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20061351DOI Listing
March 2019
1 Read

Rethinking Models of Outpatient Specialist Care in Type 2 Diabetes Using eHealth: Study Protocol for a Pilot Randomised Controlled Trial.

Int J Environ Res Public Health 2019 Mar 18;16(6). Epub 2019 Mar 18.

Centre for Health Services Research, Faculty of Medicine, Brisbane, The University of Queensland, QLD 4102, Australia.

Conventional outpatient services are unlikely to meet burgeoning demand for diabetes services given increasing prevalence of diabetes, and resultant impact on the healthcare workforce and healthcare costs. Disruptive technologies (such as smartphone and wireless sensors) create an opportunity to redesign outpatient services. In collaboration, the Department of Diabetes and Endocrinology at Brisbane Princess Alexandra Hospital, the University of Queensland Centre for Health Services Research and the Australian e-Health Research Centre developed a mobile diabetes management system (MDMS) to support the management of complex outpatient type 2 diabetes mellitus (T2DM) adults. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/1660-4601/16/6/959
Publisher Site
http://dx.doi.org/10.3390/ijerph16060959DOI Listing
March 2019
1 Read

The Epidemiology, Risk Profiling and Diagnostic Challenges of Nonalcoholic Fatty Liver Disease.

Medicines (Basel) 2019 Mar 18;6(1). Epub 2019 Mar 18.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Nonalcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of liver damage from the more prevalent (75%⁻80%) and nonprogressive nonalcoholic fatty liver (NAFL) category to its less common and more ominous subset, nonalcoholic steatohepatitis (NASH). NAFLD is now the most common cause of chronic liver disease in the developed world and is a leading indication for liver transplantation in United States (US). The global prevalence of NAFLD is estimated to be 25%, with the lowest prevalence in Africa (13. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicines6010041DOI Listing
March 2019
1 Read

Understanding the gut-kidney axis among biopsy-proven diabetic nephropathy, type 2 diabetes mellitus and healthy controls: an analysis of the gut microbiota composition.

Acta Diabetol 2019 Mar 19. Epub 2019 Mar 19.

Kidney Research Laboratory, Division of Nephrology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China.

Aims: Type 2 diabetes mellitus (TDM) has a rising prevalence and gut microbiota involvement is increasingly recognized. Diabetic nephropathy (DN) is a major complication of TDM. The aim of the study was to understand the gut-kidney axis by an analysis of gut microbiota composition among biopsy-proven DN, TDM without kidney disease, and healthy control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00592-019-01316-7DOI Listing
March 2019
2 Reads