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    [Psoriasis comorbidities].
    Cas Lek Cesk 2017 ;156(3):119-122
    Psoriasis is a chronic inflammatory skin disease affecting 2-4 % of Central European population. Nowadays, we know that psoriasis is not limited to the skin but is connected with several comorbidities like, psoriatic arthritis (around 25 %), Crohn's disease, ulcerative colitis, Bechterev, non-alcoholic liver steatosis, psychiatric disorders and mainly diseases of the so called metabolic syndrome, like diabetes mellitus type 2, arterial hypertension or dyslipidemia. In the last years, new information is arising which connect psoriasis with sleep apnoe and chronic obstructive pulmonary disease. Read More

    Cost and Health Care Utilization Implications of Bariatric Surgery Versus Intensive Lifestyle and Medical Intervention for Type 2 Diabetes.
    Obesity (Silver Spring) 2017 Jul 19. Epub 2017 Jul 19.
    Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.
    Objective: The aim of this study was to compare the cost and health care utilization of patients with obesity and type 2 diabetes mellitus (T2DM) randomized into either Roux-en-Y gastric bypass (RYGB) surgery or an intensive lifestyle and medical intervention (ILMI).

    Methods: This analysis (N = 745) is based on 2-year follow-up of a small randomized controlled trial (RCT); adult patients with obesity and T2DM were recruited between 2011 and 2012 from Kaiser Permanente Washington. Comparisons were made for patients randomized into either RYGB (N = 15) or ILMI (N = 17). Read More

    Development of a Cardiovascular Diseases Risk Prediction Model and Tools for Chinese Patients with Type 2 Diabetes Mellitus - A Population-based Retrospective Cohort Study.
    Diabetes Obes Metab 2017 Jul 19. Epub 2017 Jul 19.
    Department of Family Medicine and Primary Care, the University of Hong Kong, 3/F Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong.
    Aims: Evidence-based cardiovascular diseases(CVD) risk prediction models and tools specific for Chinese patients with type 2 diabetes mellitus(T2DM) are currently unavailable. This study aimed to develop and validate a CVD risk prediction model for Chinese T2DM patients.

    Materials And Methods: A retrospective cohort study was conducted on 137 935 Chinese patients aged 18-79 years with T2DM and without prior history of CVD, who had received public primary care services between 1 January 2010 and 31 December 2010. Read More

    Therapeutic application of GPR119 ligands in metabolic disorders.
    Diabetes Obes Metab 2017 Jul 18. Epub 2017 Jul 18.
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
    GPR119 belongs to the G protein-coupled receptor family, and exhibits dual modes of action upon ligand-dependent activation: pancreatic secretion of insulin in a glucose-dependent manner, and intestinal secretion of incretins. Hence, GPR119 has emerged as a promising target for treating type 2 diabetes mellitus without causing hypoglycemia. However, despite continuous efforts by many major pharmaceutical companies, no synthetic GPR119 ligand has been approved as a new class of anti-diabetic agents thus far, nor has one passed beyond phase II clinical studies. Read More

    High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies.
    Diabet Med 2017 Jul 18. Epub 2017 Jul 18.
    Institute of Clinical Research and Education in Medicine (IREM), Padova, Italy.
    Erectile dysfunction may be common among men with diabetes, but its prevalence is still debated. We aimed to assess the relative prevalence of erectile dysfunction in diabetes searching major databases from inception to November 2016 for studies reporting erectile dysfunction in men with Type 1 and Type 2 diabetes mellitus. We conducted a meta-analysis of the prevalence [and 95% confidence intervals (95% CIs)] of erectile dysfunction in diabetes compared with healthy controls, calculating the relative odds ratios (ORs) and 95% CIs. Read More

    Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease.
    Eur J Clin Invest 2017 Jul 19. Epub 2017 Jul 19.
    Centre of Inflammation and Metabolism/Centre for Physical Activity Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Background: Persistent inflammation is involved in the pathogenesis of chronic diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD).

    Aims: The aim of this review was to provide the reader with an update of the mechanisms whereby exercise-induced cytokines may impact cardiometabolic diseases.

    Results: Evidence exists that interleukin (IL)-1β is involved in pancreatic β-cell damage, whereas TNF-α is a key molecule in peripheral insulin resistance. Read More

    Melatonin as pleiotropic molecule with therapeutic potential for type 2 diabetes and cancer.
    Curr Med Chem 2017 Jul 18. Epub 2017 Jul 18.
    Department of Structural Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University of Lodz, Lodz. Poland.
    The incidence both of diabetes, particularly type 2 (T2DM), and cancer is increasing worldwide, making these diseases growing global health problem along with increasing healthcare expenditures. The current therapeutic approach for the treatment of these multifactorial diseases is far from satisfactory. Therefore, there is still considerable interest in searching new therapeutic strategies with the use of both natural and synthetic compounds exhibiting higher efficiency and lower toxicity compared to medicines used currently in clinical practice. Read More

    Left atrium passive ejection fraction is the most sensitive index of type 2 diabetes mellitus-related cardiac changes.
    Int J Cardiovasc Imaging 2017 Jul 18. Epub 2017 Jul 18.
    Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
    The aims of this study were to use cardiovascular magnetic resonance (CMR) cine to assess left atrium (LA) and left ventricle (LV) function and structure in normotensive type 2 diabetes mellitus (T2DM) patients and to identify the most sensitive index of those T2DM-related cardiac changes. Fifty T2DM patients with normotension (25 males, age 54.7 ± 8. Read More

    Detection of Chronic Kidney Disease by Using Different Equations of Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Analysis.
    Cureus 2017 Jun 14;9(6):e1352. Epub 2017 Jun 14.
    Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh.
    Introduction Chronic kidney disease (CKD) is a global threat due to its high mortality. It is essential to know the actual magnitude of diabetic CKD to design a specific management program. However, there is limited knowledge regarding the most suitable equation to measure CKD in patients with Type 2 diabetes mellitus (T2DM). Read More

    Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice.
    NPJ Biofilms Microbiomes 2016 6;2:16009. Epub 2016 Jul 6.
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
    An altered intestinal microbiota composition is associated with insulin resistance and type 2 diabetes mellitus. We previously identified increased intestinal levels of Eubacterium hallii, an anaerobic bacterium belonging to the butyrate-producing Lachnospiraceae family, in metabolic syndrome subjects who received a faecal transplant from a lean donor. To further assess the effects of E. Read More

    MicroRNAs and metabolic disorders - where are we heading?
    Arch Med Sci 2017 Jun 19;13(4):885-896. Epub 2017 Jan 19.
    Department of Internal Diseases, Diabetology and Clinical Pharmacology, Medical University of Lodz, Lodz, Poland.
    MicroRNAs (miRNAs, miRs) are short, non-coding molecules engaged in normal functioning of eukaryotic cells, as negative regulators of gene expression. Since the first discovery of miRNA in the early 1990s, hundreds of different miRNAs and their targets have been identified. A growing number of studies have aimed to search for microRNAs which have a key role in the regulation of insulin signaling and metabolic homeostasis. Read More

    Beneficial effects of n-3 polyunsaturated fatty acids on adiponectin levels and AdipoR gene expression in patients with type 2 diabetes mellitus: a randomized, placebo-controlled, double-blind clinical trial.
    Arch Med Sci 2017 Jun 2;13(4):716-724. Epub 2016 Sep 2.
    Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
    Introduction: There is evidence that n-3 polyunsaturated fatty acids (n-3 PUFAs) exert beneficial effects to improve type 2 diabetes mellitus (T2DM), but its complications remain poorly understood. Hypoadiponectinemia is one of the important mechanisms responsible for T2DM which necessitates developing novel therapeutic strategies. We aimed to determine the effect of n-3 PUFA supplementation on circulating adiponectin and mRNA expression of adiponectin receptors (AdipoR1, AdipoR2) and Sirt-1 in T2DM patients. Read More

    Insulin glargine 300 U/mL for basal insulin therapy in type 1 and type 2 diabetes mellitus.
    Diabetes Metab Syndr Obes 2017 30;10:273-284. Epub 2017 Jun 30.
    Department of Medicine and Geriatrics, Our Lady of Maryknoll Hospital, Hong Kong, China.
    Objective: To review published clinical studies on the efficacy and safety of new insulin glargine 300 units/mL (Gla-300), a new long-acting insulin analog, for the treatment of type 1 and type 2 diabetes mellitus (T1DM, T2DM).

    Materials And Methods: Data sources comprised primary research articles on Gla-300, including pharmacodynamic, pharmacokinetic, and clinical studies.

    Results: In pharmacodynamic and pharmacokinetic studies, Gla-300 showed a flatter time-action profile and longer duration of action than Gla-100. Read More

    Chitosan oligosaccharide improves the therapeutic efficacy of sitagliptin for the therapy of Chinese elderly patients with type 2 diabetes mellitus.
    Ther Clin Risk Manag 2017 27;13:739-750. Epub 2017 Jun 27.
    Department of Geriatrics.
    Sitagliptin improves glycemic control in type 2 diabetes mellitus (T2DM) patients but its side effects are undesirable. Chitosan oligosaccharide (COS) is expected to improve the therapeutic result as a natural product. A total of 200 elderly T2DM patients were evenly assigned into four groups: sitagliptin group (SG), receiving sitagliptin 100 mg/day; COS group (CG), receiving COS 100 mg/day; combination therapy of sitagliptin and COS group (SCG), receiving both sitagliptin and COS 100 mg/day; and placebo group (PG), receiving placebo 100 mg/day. Read More

    Cost of medication adherence and persistence in type 2 diabetes mellitus: a literature review.
    Patient Prefer Adherence 2017 30;11:1103-1117. Epub 2017 Jun 30.
    Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN, USA.
    Purpose: To explore published evidence on health care costs associated with adherence or persistence to antidiabetes medications in adults with type 2 diabetes mellitus (T2DM).

    Methods: Primary research studies published between January 2006 and December 2015 on compliance, adherence, or persistence and treatment in patients with T2DM that document a link with health care costs were identified through literature searches in bibliographic databases and 2015 abstract books for relevant DM congresses. Results were assessed for relevance by two reviewers. Read More

    Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of quinazolin-4(3H)-one derivatives as potential PPARγ and SUR agonists.
    Bioorg Med Chem 2017 Jul 8. Epub 2017 Jul 8.
    National Center for Natural Products Research, University of Mississippi, MS 38677, USA; Department of Pharmaceutics and Drug Delivery University of Mississippi, University, MS 38677, USA. Electronic address:
    Peroxisome proliferator-activated receptor gamma (PPARγ) and sulfonylurea receptor (SUR) play crucial roles in management of type-2 diabetes mellitus. In this study, a series of novel quinazoline-4(3H)-one-sulfonylurea hybrids were designed and synthesized as dual PPARγ and SUR agonists. The synthesized compounds were evaluated for their in vivo anti-hyperglycemic activities against STZ-induced hyperglycemic rats. Read More

    Contribution of family social support to the metabolic control of people with diabetes mellitus: A randomized controlled clinical trial.
    Appl Nurs Res 2017 Aug 28;36:68-76. Epub 2017 May 28.
    Department of General Nursing and Specialist at EERP/USP, Ribeirão Preto, São Paulo, Brazil. Electronic address:
    Aim: This randomized controlled clinical trial aimed to evaluate the contribution of family social support to the clinical/metabolic control of people with type 2 diabetes mellitus.

    Background: Diabetes mellitus is a chronic disease that requires continuous care in order for individuals to reach glycemic control, the primordial goal of treatment. Family social support is essential to the development of care skills and their maintenance. Read More

    Self-efficacy and self-care behaviours among adults with type 2 diabetes.
    Appl Nurs Res 2017 Aug 22;36:25-32. Epub 2017 May 22.
    Fundamentals and Administration, College of Nursing, Sultan Qaboos University, Muscat, Oman. Electronic address:
    Background: Type 2 Diabetes Mellitus (T2DM) has an impact on an individuals' health and is influenced by glycemic control.

    Aim: To examine the relationship between glycemic control, demographic and clinical factors on self-efficacy and self-care behaviours among adults with T2DM.

    Design: A correlational, descriptive study was used. Read More

    Effect Of Sitagliptin On Glycemic Control, Body Weight, Blood Pressure And Serum Lipid Profile In Type 2 Diabetic Hyperlipidemic Patients.
    J Ayub Med Coll Abbottabad 2016 Apr-Jun;28(2):369-372
    Department of Biochemistry, Chandka Medical College, Larkana Sindh, Pakistan.
    Backround: Dyslipidaemia is a global health issue in developed as well as in developing countries. People with type 2 Diabetes mellitus are more susceptible to develop dyslipidaemia and its related complications. The objective of the study was to assess the effect of sitagliptin a (DPP-4 inhibitor) oral antidiabetic drug on blood sugar, body weight, blood pressure and dyslipidaemia in type 2 diabetic patients. Read More

    Drug Non-Adherence In Type 2 Diabetes Mellitus; Predictors And Associations.
    J Ayub Med Coll Abbottabad 2016 Apr-Jun;28(2):302-307
    International Medical City Hospital, East Riffa, Bahrain.
    Background: Diabetes being a serious health issue faced by developing countries with drug adherence having pivot role for recommended glycaemic target. This study aims to determine drug non-adherence in type 2 diabetics and its predictors and associations.

    Methods: This cross sectional study was conducted after ethical approval at Medicine Dept. Read More

    Comparative efficacy and safety of gemigliptin versus linagliptin in type 2 diabetes patients with renal impairment: A 40-week extension of the GUARD randomized study.
    Diabetes Obes Metab 2017 Jul 18. Epub 2017 Jul 18.
    Korea University Ansan Hospital, Ansan, Republic of Korea.
    Aims: The present extension study evaluated the long-term safety and efficacy of gemigliptin during a 40-week follow-up period after a 12-week study.

    Methods: The main study was a randomized, placebo-controlled, double-blinded, phase IIIb study in which 50 mg of gemigliptin (N = 66) or placebo (N = 66) was administered to patients with type 2 diabetes mellitus (T2DM) with moderate or severe renal impairment over a 12-week period. Patients with a glycated haemoglobin (HbA1c) level of 7-11% and an estimated glomerular filtration rate (eGFR) of 15-59 mL/min/1. Read More

    Bacteriology Of Diabetic Foot In Tertiary Care Hospital; Frequency, Antibiotic Susceptibility And Risk Factors.
    J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):234-240
    Department of Medicine, Rawal Institute of Health Sciences, Islamabad, Pakistan.
    Background: Diabetic foot being one of the frequent and disabling complications of diabetes. In view of widespread regional variation in causative organisms and antimicrobial susceptibility, the current study aimed to determine frequency of causative organisms, their antimicrobial susceptibility and associated risk factors.

    Methods: This descriptive cross-sectional study was conducted in 6 months' duration at dept. Read More

    Dose Comparison And Side Effect Profile Of Metformin Extended Release Versus Metformin Immediate Release.
    J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):225-229
    Endocrinology Department, Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan.
    Background: Diabetes Mellitus type 2 is very common worldwide, with majority of cases in Asia Pacific region. Metformin is the first line therapy, along with lifestyle modification for all type 2 diabetics as recommended by ADA. Metformin is available as conventional Metformin Immediate Release (MIR) and Metformin Extended Release (MXR). Read More

    Design and Development of Repaglinide Microemulsion Gel for Transdermal Delivery.
    AAPS PharmSciTech 2017 Jul 17. Epub 2017 Jul 17.
    SPP School of Pharmacy and Technology Management, NMIMS University, Mumbai, 400056, India.
    Microemulsion formulation of repaglinide, a BCS class II hypoglycemic agent with limited oral bioavailability, was developed considering its solubility in various oils, surfactants, and cosurfactants. The pseudo-ternary phase diagrams for microemulsion regions were constructed by water titration method at K m 1:1 and characterized for optical birefringence, percentage transmittance, pH, refractive index, globule size, zeta potential, viscosity, drug content, and thermodynamic stability. To enhance the drug permeation and residence time, the optimized microemulsions having mean globule size of 36. Read More

    Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population.
    PeerJ 2017 13;5:e3414. Epub 2017 Jul 13.
    Endocrinology Research Centre, Moscow, Russian Federation.
    Background: The association of type 2 diabetes mellitus (T2DM) with the KCNJ11, CDKAL1, SLC30A8, CDKN2B, and FTO genes in the Russian population has not been well studied. In this study, we analysed the population frequencies of polymorphic markers of these genes.

    Methods: The study included 862 patients with T2DM and 443 control subjects of Russian origin. Read More

    Evaluation of Therapeutic Effectiveness of Prescribed Medications in Patients with Type 2 Diabetes Mellitus: Findings from a Tertiary Care Hospital, Lahore, Pakistan.
    J Pharm Bioallied Sci 2017 Apr-Jun;9(2):121-125
    Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
    Aim: The present study was aimed to highlight the current prescribing pattern of oral hypoglycemia in type 2 diabetes mellitus and to evaluate the therapeutic effectiveness of these therapeutic categories in achieving target glycemic control.

    Methods: This is a prospective, cross-sectional, observational study of 6 months' duration conducted in a tertiary care hospital of Lahore, Pakistan.

    Results: The current research recruited 145 patients presented in diabetes management center of a tertiary care hospital in Lahore, Pakistan. Read More

    Statin Therapy Prescribing for Patients with Type 2 Diabetes Mellitus: A Review of Current Evidence and Challenges.
    J Pharm Bioallied Sci 2017 Apr-Jun;9(2):80-87
    Department of Pharmacy Practice, Faculty of Pharmacy, Universiti Teknologi Mara, Puncak Alam, Selangor, Malaysia.
    Use of statin therapy in patients with type 2 diabetes mellitus (T2DM) has been recommended by most clinical guidelines. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among T2DM patients. It has been proved that statins are effective for primary or secondary CVD prophylaxis. Read More

    Effect of LDL cholesterol, statins and presence of mutations on the prevalence of type 2 diabetes in heterozygous familial hypercholesterolemia.
    Sci Rep 2017 Jul 17;7(1):5596. Epub 2017 Jul 17.
    Lipid and Vascular Unit, Department of Endocrinology and Nutrition, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Patients with heterozygous familial hypercholesterolemia (HeFH) have been reported to be less vulnerable to type 2 diabetes mellitus (T2DM), although the mechanism is unknown. The aims of the present study were to assess the effects of low density lipoprotein (LDL) cholesterol concentration and the presence of FH-causing mutations on T2DM prevalence in HeFH. Data were collected from the Dyslipidemia Registry of the Spanish Arteriosclerosis Society. Read More

    Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition.
    Sci Rep 2017 Jul 17;7(1):5581. Epub 2017 Jul 17.
    Department of Chemistry and Centre of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
    Carbasugar sodium-glucose cotransporter 2 (SGLT2) inhibitors are highly promising drug candidates for the treatment of Type 2 diabetes mellitus (T2DM). However, the clinical usage of carbasugar SGLT2 inhibitors has been underexplored, due to the lengthy synthetic routes and the lack of structure-activity relationship (SAR) studies of these compounds. Herein, we report a concise and stereodivergent synthetic route towards some novel carbasugar SGLT2 inhibitors, featuring an underexploited, regioselective, and stereospecific palladium-catalyzed allyl-aryl coupling reaction. Read More

    Coronary Artery Disease and Type 2 Diabetes Mellitus.
    Int Heart J 2017 Jul 14. Epub 2017 Jul 14.
    Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine.
    Type 2 diabetes mellitus (T2DM) is a major risk factor of coronary artery diseases (CAD). Clinical outcomes in CAD with T2DM are poor despite improvement in medications and intervention devices. Coronary artery bypass grafting (CABG) is superior to percutaneous coronary intervention (PCI) in treating diabetic patients with multivessel coronary artery diseases (MVD). Read More

    Effective waist circumference reduction rate necessary to avoid the development of type 2 diabetes in Japanese men with abdominal obesity.
    Endocr J 2017 Jul 15. Epub 2017 Jul 15.
    Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan.
    The aim of this study was to determine the effective waist circumference (WC) reduction rate in avoiding the development of type 2 diabetes mellitus (T2DM) in <55 years and ≥55 years Japanese men with abdominal obesity. The study subjects were 795 men with WC ≥85 cm, fasting plasma glucose <126 mg/dL, 2-hr plasma glucose on 75 g of oral glucose tolerance test <200 mg/dL, and HbA1c 5.6-6. Read More

    Diabetes Mellitus, Microalbuminuria, and Subclinical Cardiac Disease: Identification and Monitoring of Individuals at Risk of Heart Failure.
    J Am Heart Assoc 2017 Jul 17;6(7). Epub 2017 Jul 17.
    Multidisciplinary Cardiovascular Research Centre & Division of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom.
    Background: Patients with type 2 diabetes mellitus and elevated urinary albumin:creatinine ratio (ACR) have increased risk of heart failure. We hypothesized this was because of cardiac tissue changes rather than silent coronary artery disease.

    Methods And Results: In a case-controlled observational study 130 subjects including 50 ACR+ve diabetes mellitus patients with persistent microalbuminuria (ACR >2. Read More

    Incidence and Trends in Hypoglycemia Hospitalization in Adults With Type 1 and Type 2 Diabetes in England, 1998-2013: A Retrospective Cohort Study.
    Diabetes Care 2017 Jul 17. Epub 2017 Jul 17.
    Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
    Objective: To determine trends in hospitalization for hypoglycemia in adults with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in England.

    Research Design And Methods: Adults with T1DM or T2DM were identified from 398 of the 684 practices within the Clinical Practice Research Datalink, for which linkage to the Hospital Episode Statistics was possible. Hypoglycemia as primary reason for hospitalization between 1998 and 2013 was extracted. Read More

    Modulating effects of omega-3 fatty acids and pioglitazone combination on insulin resistance through toll-like receptor 4 in type 2 diabetes mellitus.
    Prostaglandins Leukot Essent Fatty Acids 2017 Jun 17. Epub 2017 Jun 17.
    Biochemistry department, Faculty of Pharmacy, Mansoura University, 35516, Egypt.
    Toll-like receptor 4 (TLR-4) plays important roles in innate immunity. Changes in the reduction-oxidation balance of tissues can lead to a pro-inflammatory state and insulin resistance. An action thought to be mediated by TLRs. Read More

    Partial jejunal diversion using an incisionless magnetic anastomosis system: 1-year interim results in subjects with obesity and diabetes.
    Gastrointest Endosc 2017 Jul 14. Epub 2017 Jul 14.
    West Bridgewater, Massachusetts, USA.
    Background And Aims: The majority of patients with type 2 diabetes mellitus (T2DM) have obesity. Studies show that bariatric surgery is superior to medical treatment for remission of T2DM. Nevertheless, very few patients undergo surgery, and a less-invasive endoscopic alternative is desirable. Read More

    Smoking and the risk of type 2 diabetes in Japan: A systematic review and meta-analysis.
    J Epidemiol 2017 Jul 14. Epub 2017 Jul 14.
    Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
    Cigarette smoking is the leading avoidable cause of disease burden. Observational studies have suggested an association between smoking and risk of type 2 diabetes mellitus (T2DM). We conducted a meta-analysis of prospective observational studies to investigate the association of smoking status, smoking intensity, and smoking cessation with the risk of T2DM in Japan, where the prevalence of smoking has been decreasing but remains high. Read More

    Elevated C-reactive protein, interleukin 6, tumor necrosis factor alpha and glycemic load associated with type 2 diabetes mellitus in rural Thais: a cross-sectional study.
    BMC Endocr Disord 2017 Jul 17;17(1):44. Epub 2017 Jul 17.
    Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Rd, Bangkok, 10400, Thailand.
    Background: The elevated levels of inflammatory markers, including C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL6) are supposed to be associated with type 2 diabetes mellitus (T2DM). Frequent high glycemic load (GL) consumption, central obesity, and a lack of physical activity are considered to be T2DM risk factors. This study aimed to determine the difference of these inflammatory markers as well as GL in individuals with versus those without T2DM in rural Thais. Read More

    Active subfractions of Abelmoschus esculentus substantially prevent free fatty acid-induced β cell apoptosis via inhibiting dipeptidyl peptidase-4.
    PLoS One 2017 17;12(7):e0180285. Epub 2017 Jul 17.
    Division of Basic Medical Science, Hungkuang University, Shalu District, Taichung, Taiwan.
    Lipotoxicity plays an important role in exacerbating type 2 diabetes mellitus (T2DM) and leads to apoptosis of β cells. Recently dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as a useful tool in the treatment of T2DM. DPP-4 degrades type 1 glucagon-like peptide (GLP-1), and GLP-1 receptor (GLP-1R) signaling has been shown to protect β cells by modulating AMPK/mTOR, PI3K, and Bax. Read More

    Is cardiovascular disease in patients with diabetes associated with serum levels of MMP-2, LOX, and the elastin degradation products ELM and ELM-2?
    Scand J Clin Lab Invest 2017 Jul 17:1-5. Epub 2017 Jul 17.
    a Department of Clinical Biochemistry and Pharmacology , Odense University Hospital, University of Southern Denmark , Odense , Denmark.
    Background: Diabetes mellitus type 2 (T2DM) is a significant risk factor for the development of cardiovascular diseases (CVDs). In a previous microarray study of internal mammary arteries from patients with and without T2DM, we observed several elastin-related genes with altered mRNA-expression in diabetic patients, namely matrix metalloproteinase 2 (MMP-2), lysyl oxidase (LOX) and elastin itself. In this study we investigate whether the serum concentrations of elastin-related proteins correlate to signs of CVD in patients with T2DM. Read More

    Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients.
    Int J Mol Sci 2017 Jul 15;18(7). Epub 2017 Jul 15.
    Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe University Hospital, 60590 Frankfurt am Main, Germany.
    Sphingolipids are characterized by a broad range of bioactive properties. Particularly, the development of insulin resistance, a major pathophysiological hallmark of Type 2 Diabetes mellitus (T2D), has been linked to ceramide signaling. Since vitamin D supplementation may slow down T2D progression by improving glucose concentrations and insulin sensitivity, we investigated whether vitamin D supplementation impacts on plasma sphingolipid levels in T2D patients. Read More

    The efficacy and safety of adding either vildagliptin or glimepiride to ongoing metformin therapy in patients with type 2 diabetes mellitus.
    Expert Opin Pharmacother 2017 Jul 17:1-8. Epub 2017 Jul 17.
    a Division of Endocrinology and Metabolism, Department of Medicine , Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Republic of Korea.
    Objective: To compare the effects of either vildagliptin or glimepiride on glycemic variability, oxidative stress, and endothelial parameters in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin alone.

    Methods: In this randomized, open-label, parallel study, 34 patients with T2DM being treated with metformin having an HbA1c of 7.0-10. Read More

    Low Prevalence of Insulin Resistance among Iranian Patients with Chronic Hepatitis C Virus Infection: A Case-Control Study.
    Curr Diabetes Rev 2017 Jul 14. Epub 2017 Jul 14.
    Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz. Iran.
    Background: Association between chronic hepatitis C virus (CHC) infection and type 2 diabetes mellitus has been challenging in recent decades. Despite of extensive research in this area, there is no general agreement on the direct effect of HCV infection on insulin resistance.

    Patients And Methods: The study was performed in 52 CHC patients (mean age = 39. Read More

    Metabolic surgery: gastric bypass for the treatment of type 2 diabetes mellitus.
    Transl Gastroenterol Hepatol 2017 6;2:58. Epub 2017 Jun 6.
    Division of Bariatric Surgery Centro CIEN, Diagnomed, Affiliated Institution to the University of Buenos Aires, Buenos Aires, Argentina.
    Type 2 diabetes mellitus (T2DM) is one of the largest health emergencies of the 21st century given the worldwide increase of obesity during the last decades and its close association. T2DM is an inherited, polygenic and chronic disease caused by the interaction between several genetic variants in genes and the environment. The continuous search for new and more effective tools to achieve appropriate glycemic control became imperative in order to reduce long-term complications and mortality rates related to T2DM. Read More

    Association between Hemoglobin Levels and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: A Cross-Sectional Study Using Electronic Health Records.
    J Diabetes Res 2017 21;2017:2835981. Epub 2017 Jun 21.
    Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
    Objective: To investigate the relationship between hemoglobin levels and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM).

    Methods: 1511 patients with T2DM were included in the study. DPN was diagnosed based on symptoms, signs, and laboratory tests. Read More

    Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus.
    Cureus 2017 Jun 13;9(6):e1347. Epub 2017 Jun 13.
    Internal Medicine, Jinnah Sindh Medical University (SMC).
    Context: Dyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes.

    Purpose: The main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. Read More

    E-healthcare for Diabetes Mellitus Type 2 Patients - A Randomised Controlled Trial in Slovenia.
    Zdr Varst 2017 Sep 26;56(3):150-157. Epub 2017 May 26.
    University of Primorska, Institute Andrej Marušič, Muzejski trg 2, 6000Koper, Slovenia.
    Background: Telemonitoring and web-based interventions are increasingly used in primary-care practices in many countries for more effective management of patients with diabetes mellitus (DM). A new approach in treating patients with diabetes mellitus in family practices, based on ICT use and nurse practitioners, has been introduced and evaluated in this study.

    Method: Fifteen Slovene family practices enrolled 120 DM patients treated only with a diet regime and/or tablets into the study. Read More

    Clinically Apparent Arterial Thrombosis in Persons with Systemic Vasculitis.
    Int J Rheumatol 2017 21;2017:3572768. Epub 2017 Jun 21.
    Division of Rheumatology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.
    Objective: To estimate the incidence rate of clinically apparent arterial thrombotic events and associated comorbidities in patients with primary systemic vasculitis.

    Methods: Using large cohort administrative data from Quebec, Canada, we identified patients with vasculitis, including polyarteritis nodosa (PAN) and granulomatosis with polyangiitis (GPA). Incident acute myocardial infarctions (AMIs) and cerebrovascular accidents (CVAs) after the diagnosis of vasculitis were ascertained in the PAN and GPA group via billing and hospitalization data. Read More

    Biological impact of advanced glycation endproducts on estrogen receptor-positive MCF-7 breast cancer cells.
    Biochim Biophys Acta 2017 Jul 13. Epub 2017 Jul 13.
    School of Healthcare Science, Manchester Metropolitan University, Manchester, M1 5GD, United Kingdom.. Electronic address:
    Diabetes mellitus potentiates the risk of breast cancer. We have previously described the pro-tumorigenic effects of advanced glycation endproducts (AGEs) on estrogen receptor (ER)-negative MDA-MB-231 breast cancer cell line mediated through the receptor for AGEs (RAGE). However, a predominant association between women with ER-positive breast cancer and type 2 diabetes mellitus has been reported. Read More

    An overview on biological functions and emerging therapeutic roles of apelin in diabetes mellitus.
    Diabetes Metab Syndr 2017 Jul 4. Epub 2017 Jul 4.
    Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
    Type 2 diabetes mellitus is a common type of diabetes and considered as multifactorial disease. Apelin is an adipokine which secreted from white adipose tissue and involved in various functions such as insulin sensitivity and food intake. Many studies showed that apelin has a crucial role in diabetes and its concentration will change in relation with insulin resistance. Read More

    Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes: Analysis from the Japan Diabetes Complications Study (JDCS).
    J Psychosom Res 2017 Aug 31;99:34-39. Epub 2017 May 31.
    Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan. Electronic address:
    Objective: The aims of this study are to confirm whether the excess mortality caused by depressive symptoms is independent of severe hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and to evaluate the association between all-cause mortality and degrees of severity of depressive symptoms in Japanese patients with T2DM.

    Methods: A total of 1160 Japanese patients with T2DM were eligible for this analysis. Participants were followed prospectively for 3years and their depressive states were evaluated at baseline by the Center for Epidemiologic Studies Depression Scale (CES-D). Read More

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