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    Divided consumption of late-night-dinner improves glycemic excursions in patients with type 2 diabetes: A randomized cross-over clinical trial.
    Diabetes Res Clin Pract 2017 May 16;129:206-212. Epub 2017 May 16.
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
    Aims: To explore the acute effect of late-night-dinner and divided dinner on postprandial glucose levels in patients with type 2 diabetes.

    Methods: Sixteen patients were randomly assigned to this cross-over study. Each patient wore a continuous glucose monitor for 5days and consumed identical test meals for 3days. Read More

    Metformin Inhibits P. gingivalis Lipopolysaccharide (LPS)-influenced Inflammatory Response in Human Gingival Fibroblasts via Regulating Activating Transcription Factor-3 (ATF3) Expression.
    J Periodontol 2017 May 26:1-20. Epub 2017 May 26.
    Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Shandong, Jinan, China.
    Background: Chronic periodontitis is one of the most prevalent oral diseases, which is associated with Porphyromonas gingivalis (P. gingivalis) Lipopolysaccharide (LPS) infection, and has profound effects on type 2 diabetes mellitus (DM2). Metformin, a well-known antidiabetic agent, has been reported to exert anti-inflammatory effects on various cells. Read More

    Aqueous humor endothelin-1 and total retinal blood flow in patients with non-proliferative diabetic retinopathy.
    Eye (Lond) 2017 May 26. Epub 2017 May 26.
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
    PurposeThe purpose of this study was to determine the association between aqueous ET-1 levels and total retinal blood flow (TRBF) in patients with non-insulin-dependent type 2 diabetes mellitus (T2DM) and early non-proliferative diabetic retinopathy (NPDR).Patients and methodsA total of 15 age-matched controls and 15 T2DM patients with NPDR were recruited into the study. Aqueous humor (~80-120 μl) was collected before cataract surgery to measure the levels of ET-1 using suspension multiplex array technology. Read More

    Influencing of antioxidants' gene variants on risk of diabetes mellitus and its complications: a systematic review.
    Minerva Endocrinol 2017 May 26. Epub 2017 May 26.
    Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
    Introduction: Oxidative stress has a key role in pathophysiology of type 2 diabetes mellitus (T2DM) and its complications as a most common health problem. Due to controversial evidence regarding the association between antioxidants' gene varients and T2DM, our aim was a systematic review of the current meta-analyses.

    Evidence Acquistion: All meta-analysis' studies which assessed the association of single nucleotide polymorphisms of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX), glutathione S transferase (GST), nitric oxide synthase (NOS) and nicotinamide adenine dinucleotide phosphate oxidase (NOX) with T2DM and its complications were systematically extracted from PubMed, Scopus and Web of Science databases up to January 2016. Read More

    A randomized clinical trial evaluating the efficacy and safety of the once-weekly dipeptidyl peptidase-4 inhibitor omarigliptin in patients with type 2 diabetes inadequately controlled on metformin monotherapy.
    Curr Med Res Opin 2017 May 26:1-20. Epub 2017 May 26.
    b Merck & Co., Inc. , Kenilworth , NJ , USA.
    Objective: To examine the efficacy and safety of the once-weekly (q.w.) dipeptidyl peptidase-4 inhibitor, omarigliptin, in patients with type 2 diabetes (T2DM) and inadequate glycemic control on metformin monotherapy. Read More

    High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect.
    Eur J Drug Metab Pharmacokinet 2017 May 25. Epub 2017 May 25.
    Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.
    Background And Objective: Gliclazide is a drug commonly used in type 2 diabetes mellitus. Recently, gliclazide has shown desirable pharmacological effects such as immunoregulatory and anti-clotting effects, which suggests potential applications in type 1 diabetes mellitus (T1DM). Gliclazide has variable absorption after oral administration, and thus using targeted-delivery techniques, such as microencapsulation, may optimise gliclazide absorption and potential applications in T1DM. Read More

    Effect of variable antidiabetic treatments strategy on oxidative stress markers in obese patients with T2DM.
    Diabetol Metab Syndr 2017 25;9:27. Epub 2017 May 25.
    Medical Biochemistry Department, Faculty of Medicine, Ain Shams University (ASU), Cairo, Egypt.
    Aim: To evaluate the effect of different anti-diabetic treatment strategy on oxidative stress markers in patients with type 2 diabetes mellitus (T2DM).

    Subject And Methods: A total of 93 patients with T2DM treated with metformin (G1 = 25), OHA (G2 = 22), OA and insulin (G3 = 26) and insulin alone (G4 = 20). In all patients, lipid profile and glycemic indices were assessed using routine laboratory tests. Read More

    Effect of Sodium-Glucose Cotransport-2 Inhibitors on Blood Pressure in People With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of 43 Randomized Control Trials With 22 528 Patients.
    J Am Heart Assoc 2017 May 25;6(6). Epub 2017 May 25.
    Non-Communicable Disease Research Unit, South African Medical Research Council and University of Cape Town, South Africa.
    Background: The sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of oral hypoglycemic agents. We undertake a systematic review and meta-analysis of prospective studies to determine the effect of SGLT2 on blood pressure (BP) among individuals with type 2 diabetes mellitus.

    Methods And Results: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched to identify trial registries evaluating the impact of SGLT2 on BP. Read More

    Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes.
    FASEB J 2017 May 25. Epub 2017 May 25.
    Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Osaka, Japan;
    Glial fibrillary acidic protein (GFAP) is expressed in peri-islet Schwann cells as well as in glia cells and has been reported to be an autoantigen candidate for type 1 diabetes mellitus (T1DM). We confirmed that the production of the autoantibodies GFAP and glutamic acid decarboxylase 65 (GAD65) was increased and inversely correlated with the concentration of secreted C peptide in female nonobese diabetic mice (T1DM model). Importantly, the development of T1DM in female nonobese diabetic mice at 30 wk of age was predicted by the positive GFAP autoantibody titer at 17 wk. Read More

    Haemoglobin A1c as a screening tool for type 2 diabetes and prediabetes in populations of Swedish and Middle-East ancestry.
    Prim Care Diabetes 2017 May 22. Epub 2017 May 22.
    Center for Primary Health Care Research, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
    Aims: To explore and compare sensitivity and specificity for HbA1c ≥48mmol/mol as a predictor for type 2 diabetes mellitus (T2DM) in two populations with different ethnicity and to examine the predictive value of two levels of HbA1c (≥42mmol/mol, ≥39mmol/mol) for prediabetes in these populations.

    Methods: Four cohorts were examined with an oral glucose tolerance test. (1) The MEDIM Study (n=1991 individuals of Swedish and Iraqi ancestry); (2) The Skaraborg Project (n=1327 individuals of Swedish ancestry); (3) The 4-D study (n=424 individuals of Swedish, Iraqi and Turkish ancestry); (4) The Flemingsberg study (n=212 participants of Turkish ancestry). Read More

    Pro- and Antiarrhythmic Actions of Sulfonylureas: Mechanistic and Clinical Evidence.
    Trends Endocrinol Metab 2017 May 22. Epub 2017 May 22.
    Center for Pharmacoepidemiology Research and Training, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
    Sulfonylureas are the most commonly used second-line drug class for treating type 2 diabetes mellitus (T2DM). While the cardiovascular safety of sulfonylureas has been examined in several trials and nonrandomized studies, little is known of their specific effects on sudden cardiac arrest (SCA) and related serious arrhythmic outcomes. This knowledge gap is striking, because persons with DM are at increased risk of SCA. Read More

    Design and rationale of the ODYSSEY DM-DYSLIPIDEMIA trial: lipid-lowering efficacy and safety of alirocumab in individuals with type 2 diabetes and mixed dyslipidaemia at high cardiovascular risk.
    Cardiovasc Diabetol 2017 May 25;16(1):70. Epub 2017 May 25.
    Sanofi, Paris, France.
    Background: Type 2 diabetes mellitus (T2DM) is often associated with mixed dyslipidaemia, where non-high-density lipoprotein cholesterol (non-HDL-C) levels may more closely align with cardiovascular risk than low-density lipoprotein cholesterol (LDL-C). We describe the design and rationale of the ODYSSEY DM-DYSLIPIDEMIA study that assesses the efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, versus lipid-lowering usual care in individuals with T2DM and mixed dyslipidaemia at high cardiovascular risk with non-HDL-C inadequately controlled despite maximally tolerated statin therapy. For the first time, atherogenic cholesterol-lowering with a PCSK9 inhibitor will be assessed with non-HDL-C as the primary endpoint with usual care as the comparator. Read More

    The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism.
    Nutr J 2017 May 25;16(1):34. Epub 2017 May 25.
    Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, International Campus, Tehran University of Medical Sciences, Hojatdoost Ave., Naderi St., Keshavarz Blvd., Tehran, Iran.
    Background: People may have different responses to the same environmental changes. It has been reported that genome variations may be responsible for these differences. Also, HDL subfractions may be influenced by different genetic variations. Read More

    β-Cell function in postmenopausal women with isolated postchallenge hyperglycemia.
    J Diabetes 2017 May 22. Epub 2017 May 22.
    Department of Medicine, National Yang-Ming University Hospital, Yi-Lan, Taiwan.
    Background: Isolated postchallenge hyperglycemia (IPH) is an early stage of type 2 diabetes mellitus (T2DM) with fasting glucose < 126 mg/dL and 2 h glucose ≥ 200 mg/dL. Observations of insulin secretion profile in subjects with IPH may provide insight to the pathogenesis of T2DM in older women.

    Methods: We recruited 555 naturally postmenopausal women without a history of T2DM for this study. Read More

    Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy.
    J Gene Med 2017 May 22. Epub 2017 May 22.
    School of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.
    Background: Little is known about the contribution of ARHGAP22 polymorphism to diabetic retinopathy (DR) risk. We performed a case-control study to investigate the associations between ARHGAP22 and the risk of DR in a Chinese Han population.

    Methods: A total of 341 patients with type 2 diabetes mellitus (T2DM) were selected. Read More

    Preventing Progression from Gestational Diabetes Mellitus to Diabetes: A Thought-filled Review.
    Diabetes Metab Res Rev 2017 May 19. Epub 2017 May 19.
    Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY.
    Women with a history of gestational diabetes (GDM) are at high risk for developing type 2 diabetes mellitus (T2DM). In studies with long periods of follow up, diabetes incidence of up to 70% has been reported. The appropriate follow up of women following a pregnancy complicated by GDM has not been studied. Read More

    Direct medical costs of severe hypoglycaemic events in patients with type 2 diabetes in England: A retrospective database study.
    Int J Clin Pract 2017 May 23. Epub 2017 May 23.
    Pharmatelligence, Cardiff, UK.
    Aims: Hypoglycaemia in patients with diabetes can be induced by insulins and sulfonylureas. We assessed the real-world impact of specific monotherapy and combination regimens on hypoglycaemic events requiring hospitalisation and related secondary costs to the English healthcare system.

    Methods: This retrospective observational study used the Clinical Practice Research Datalink with linked hospital admission data during 2008-2012. Read More

    Influence of diabetes mellitus on the immunity to human tuberculosis.
    Immunology 2017 May 22. Epub 2017 May 22.
    National Institutes of Health-International Center for Excellence in Research, Chennai, India.
    Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary tuberculosis, with development of DM pandemic in countries where tuberculosis (TB) is also endemic. Understanding the impact of DM on TB and the determinants of co-morbidity is essential in responding to this growing public health problem with improved therapeutic approaches. Despite the clinical and public health significance posed by the dual burden of TB and DM, little is known about the immunological and biochemical mechanisms of susceptibility. Read More

    Validating the European Health Literacy Survey Questionnaire in people with type 2 diabetes. Latent trait analyses applying multidimensional Rasch modelling and confirmatory factor analysis.
    J Adv Nurs 2017 May 24. Epub 2017 May 24.
    University of Oslo.
    Aim: To validate the European Health Literacy Survey Questionnaire (HLS-EU-Q47) in people with type 2 diabetes mellitus.

    Background: The HLS-EU-Q47 latent variable is outlined in a framework with four cognitive domains integrated in three health domains, implying 12 theoretically defined subscales. Valid and reliable health literacy measurers are crucial to effectively adapt health communication and education to individuals and groups of patients. Read More

    Polycystic Ovary Morphology Is Associated with Insulin Resistance in Women with Polycystic Ovary Syndrome.
    Clin Endocrinol (Oxf) 2017 May 20. Epub 2017 May 20.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea.
    Background/objectives: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterised by chronic anovulation, hyperandrogenenism, polycystic ovary morphology (PCOM), and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, recent studies have shown controversial results. The aim of this study was to determine the relationship between PCOM and insulin resistance. Read More

    Relationship between carotid atherosclerosis and coronary artery calcification in asymptomatic diabetic patients: A prospective multicenter study.
    Clin Cardiol 2017 May 25. Epub 2017 May 25.
    Department of Cardiology, Royal Free Hospital, London, United Kingdom.
    Background: The value of screening sub-clinical atherosclerosis in asymptomatic patients with type 2 diabetes mellitus (T2DM) remains controversial.

    Hypothesis: An integrated model incorporating carotid intima-media thickness (CIMT) and carotid plaque with traditional risk factors can be used to predict prevalence and severity of coronary artery calcification in asymptomatic T2DM patients.

    Methods: A cohort of 262 asymptomatic T2DM patients were prospectively studied with carotid ultrasound to evaluate CIMT and carotid plaque and also a computed tomography coronary artery calcium (CT-CAC) scan. Read More

    The population impact of obesity, sedentary lifestyle, and tobacco and alcohol consumption on the prevalence of type 2 diabetes: Analysis of a health population survey in Chile, 2010.
    PLoS One 2017 25;12(5):e0178092. Epub 2017 May 25.
    Public Health Nutrition Program, School of Public Health, University of Chile, Santiago, Chile.
    Aim: To estimate the impact of tobacco use, sedentary lifestyle, obesity and alcohol consumption on type 2 diabetes mellitus (T2DM) prevalence in the Chilean population.

    Methods: The study-included 5,293 subjects with fasting glycaemia levels from the nationwide cross-sectional health survey in 2010, commissioned by the Ministry of Health, Chile. Crude and Adjusted Odds Ratio to T2DM and its corresponding 95% confidence interval were estimated through logistic regressions. Read More

    Insulin resistance according to β-cell function in women with polycystic ovary syndrome and normal glucose tolerance.
    PLoS One 2017 25;12(5):e0178120. Epub 2017 May 25.
    Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
    Background: Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and compensatory hyperinsulinemia. IR is recognized as a major risk factor for the development of type 2 diabetes mellitus. However, few studies have investigated IR in women with PCOS and normal glucose tolerance. Read More

    Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity.
    PLoS One 2017 24;12(5):e0176267. Epub 2017 May 24.
    Clinical Research Unit, Center of Internal Medicine, Justus Liebig University, Giessen, Germany.
    The onset and progression of diabetes mellitus type 2 is highly contingent on the amount of functional beta-cell mass. An underlying cause of beta-cell decay in diabetes is oxidative stress, which markedly affects the insulin producing pancreatic cells due to their poor antioxidant defence capacity. Consequently, disturbances of cellular redox signaling have been implicated to play a major role in beta-cell loss in diabetes mellitus type 2. Read More

    Enemies or weapons in hands: investigational anti-diabetic drug glibenclamide and cancer risk.
    Expert Opin Investig Drugs 2017 May 25. Epub 2017 May 25.
    b Department of Hematology , the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing 210029 , China.
    Introduction: Epidemiological evidence suggests that diabetes is associated with elevated cancer risk through the actions of hyperglycemia, hyperinsulinemia and chronic inflammation. Metformin, a first-line medication for type 2 diabetes mellitus, arouses growing concerns on its anti-cancer effect. However, data regarding the effect of glibenclamide on tumor growth and cancer risk are less consistent, which may be a potential anti-cancer drug. Read More

    The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer's Disease, Based on a Mechanistic Target of Rapamycin Pathway.
    CNS Drugs 2017 May 24. Epub 2017 May 24.
    Key Laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan, Shanxi, China.
    The mechanistic target of rapamycin (mTOR) is an important molecule that connects aging, lifespan, energy balance, glucose and lipid metabolism, and neurodegeneration. Rapamycin exerts effects in numerous biological activities via its target protein, playing a key role in energy balance, regulation of autophagy, extension of lifespan, immunosuppression, and protection against neurodegeneration. There are many similar pathophysiological processes and molecular pathways between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), and pharmacologic agents used to treat T2DM, including glucagon-like peptide-1 (GLP-1) analogs, seem to be beneficial for AD. Read More

    Invasive Listeria monocytogenes Gastroenteritis Leading to Stupor, Bacteremia, Fever, and Diarrhea: A Rare Life-Threatening Condition.
    J Investig Med High Impact Case Rep 2017 Apr-Jun;5(2):2324709617707978. Epub 2017 May 9.
    Department of Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, PA, USA.
    Listeria monocytogenes is a gram-positive, rod-shaped organism that can cause serious infections such as meningitis, invasive gastroenteritis, and endocarditis. Every year 1600 people in the United States are affected, with significant mortality of 260 people annually. Listeria gastroenteritis has the third highest mortality rate among all the food-borne infection. Read More

    Diabetes Risk Score in a Young Student Population in Jordan: A Cross-Sectional Study.
    J Diabetes Res 2017 29;2017:8290710. Epub 2017 Apr 29.
    Faculty of Medicine, Hashemite University, Zarqa, Jordan.
    Background. The Middle East is the home to the most obese population in the world, and type 2 diabetes mellitus is endemic in the region. However, little is known about risk factors for diabetes in the younger age groups. Read More

    Effect of diet on type 2 diabetes mellitus: A review.
    Int J Health Sci (Qassim) 2017 Apr-Jun;11(2):65-71
    Faculty of Industrial Management, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300 Gambang, Kuantan, Pahang, Malaysia.
    Globally, type 2 diabetes mellitus (T2DM) is considered as one of the most common diseases. The etiology of T2DM is complex and is associated with irreversible risk factors such as age, genetic, race, and ethnicity and reversible factors such as diet, physical activity and smoking. The objectives of this review are to examine various studies to explore relationship of T2DM with different dietary habits/patterns and practices and its complications. Read More

    [Efficacy of two bariatric surgeries in type 2 diabetic patients with a body mass index of 25-27.5].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 May;37(5):693-697
    Southern Medical University, Guangzhou 510515, China.E-mail:
    Objective: To evaluate the therapeutic effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic duodenal-jejunal bypass with sleeve gastrectomy (SADJB-SG) in patients with type 2 diabetes mellitus and a low body mass index (BMI) of 25-27.5.

    Methods: Thirty-one type 2 diabetic patients with a BMI of 25-27. Read More

    Systematic review and meta-analysis of the effect of metformin treatment on overall mortality rates in women with endometrial cancer and type 2 diabetes mellitus.
    Maturitas 2017 Jul 8;101:6-11. Epub 2017 Apr 8.
    School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Lima 9, Peru; University of Connecticut/Hartford Hospital Evidence-based Practice Center, 80 Seymour St, Hartford, CT 06102, USA. Electronic address:
    Background: Obesity, insulin resistance and type 2 diabetes mellitus (T2DM) have been associated with endometrial cancer (EC). In this systematic review and meta-analysis we evaluated the effect of metformin on clinical outcomes in patients with EC and insulin resistance or T2DM.

    Methods: Four research databases were searched for original articles published in all languages up to 30 October 2016. Read More

    Prescription Patterns and Disease Control in Type 2 Diabetes Mellitus Patients in Nursing Home and Home Care Settings: A Retrospective Analysis in Germany.
    J Diabetes Sci Technol 2017 May 1:1932296817710477. Epub 2017 May 1.
    2 Faculty of Medicine, University of Paris 5, Paris, France.
    Aim: The aim of this study was to analyze prescription patterns and disease control in patients with type 2 diabetes mellitus (T2DM) in nursing home and home care settings in Germany.

    Methods: The present study is based on data from the Disease Analyzer database (QuintilesIMS). Patients with an initial diagnosis of T2DM and documented HbA1c values between January 2011 and December 2015 were included in the analysis. Read More

    Exploring the Effectiveness of Smart Technologies in the Management of Type 2 Diabetes Mellitus.
    J Diabetes Sci Technol 2017 May 1:1932296817711198. Epub 2017 May 1.
    4 John Hunter Hospital, New Lambton, New South Wales, Australia.
    The global epidemic of diabetes, with increasing prevalence of type 2 diabetes (T2D), is placing a huge burden on health care management and financial systems. Unless new strategic solutions are developed, the increasing prevalence of T2D will result in a significant rise in morbidity, health care costs, and complications associated with diabetes. The introduction of smart devices in diabetes management may provide meaningful improvements in clinical outcomes, patient engagement, as well as potential cost reductions for the health care system. Read More

    Do you know this syndrome? Werner syndrome.
    An Bras Dermatol 2017 Mar-Apr;92(2):271-272
    School of Medicine, Selcuk University - Konya, Turkey.
    Werner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include: senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, type 2 diabetes mellitus, ischemic heart disease and hypogonadism. The syndrome begins to become apparent in adolescence but it is usually diagnosed in the third or fourth decade of life. Read More

    Safety and efficiency of SGLT2 inhibitor combining with insulin in subjects with diabetes: Systematic review and meta-analysis of randomized controlled trials.
    Medicine (Baltimore) 2017 May;96(21):e6944
    aDepartment of Endocrinology, Endocrine Key Laboratory of Ministry of Health, Peking Union Medical College Hospital, China Academy of Medical Sciences Peking Union Medical College and Peking Union Medical College, Beijing bDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin cHealth Science Popularization Research Center, Chinese Academy of Medical Sciences, Beijing dDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, China.
    Background: We aimed to assess the safety and efficiency of the novel sodium glucose co-transporter 2 (SGLT2) inhibitor in combinations with insulin for type 1 and type 2 diabetes mellitus (T1DM and T2DM).

    Methods: We searched Medline, Pubmed, Embase, and the Cochrane Collaboration Library from January 2010 to December 2016 without restriction of language. FDA data and Clinical Trials (http://www. Read More

    Differences in risk factors of malignancy between men and women with type 2 diabetes: A retrospective case-control study.
    Oncotarget 2017 May 9. Epub 2017 May 9.
    Warsaw Medical University, Department of Internal Diseases and Diabetology, Warsaw, Poland.
    Background: The aim of this multicenter, retrospective, case-control study was to identify differences in risk factors of malignancy between men and women with type 2 diabetes.

    Results: Among women the most prevalent malignancies were: breast and uterine cancers (35.6% and 14. Read More

    Influence of endurance training on skeletal muscle mitophagy regulatory proteins in type 2 diabetic men.
    Endocr Res 2017 May 24:1-6. Epub 2017 May 24.
    a Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine , German Sport University Cologne , Germany.
    Background: Mitophagy is a form of autophagy for the elimination of mitochondria. Mitochondrial content and function are reduced in the skeletal muscle of patients with type 2 diabetes mellitus (T2DM). Physical training has been shown to restore mitochondrial capacity in T2DM patients, but the role of mitophagy has not been examined in this context. Read More

    Metformin improves the glucose and lipid metabolism via influencing the level of serum total bile acids in rats with streptozotocin-induced type 2 diabetes mellitus.
    Eur Rev Med Pharmacol Sci 2017 May;21(9):2232-2237
    Endocrinology Department, Jinan Central Hospital affiliated to Shandong University, Jinan, Shandong Province, P.R. China.
    Objective: To study the effects of metformin on streptozotocin-induced type 2 diabetes mellitus (T2DM) in rats.

    Materials And Methods: Wistar male rats were divided into two groups: standard diet (SD, n = 20) group and high-fat diet (HFD, n = 80) group. Twenty rats in HFD group were randomly treated with metformin (EI group). Read More

    Intelligent Internet-based information system optimises diabetes mellitus management in communities.
    HIM J 2017 Jan 1:1833358317697717. Epub 2017 Jan 1.
    1 School of General Practice and Continuing Education of Capital Medical University, Beijing, People's Republic of China.
    Objective: To evaluate the effect of an intelligent Internet-based information system upon optimising the management of patients diagnosed with type 2 diabetes mellitus (T2DM).

    Methods: In 2015, a T2DM information system was introduced to optimise the management of T2DM patients for 1 year in Fangzhuang community of Beijing, China. A total of 602 T2DM patients who were registered in the health service centre of Fangzhuang community were enrolled based on an isometric sampling technique. Read More

    The Effect of 12 Weeks Aerobic, Resistance and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women.
    Diabetes Metab J 2017 May 18. Epub 2017 May 18.
    Shiraz HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: Recent studies have shown that omentin-1 derived from adipokines can affect physiological regulations and some metabolic dis-eases such as type 2 diabetes mellitus (T2DM).

    Methods: The purpose of this study was to examine the impact of 12 weeks of aerobic (cycle ergometer), resistance, and combined exercises on omentin-1 level, glucose and insulin resistance indices in overweight middle age women with T2DM. In this study, 60 overweight middle age diabetic women were selected using simple random sampling and they were assigned to three groups of aerobic exercise (n=12), resistant exercise (n=12) and combined exercise (n=13), and one control group (n=15). Read More

    Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs.
    Diabetes Metab J 2017 May 22. Epub 2017 May 22.
    The Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA, USA.
    The notion that obesity-induced inflammation mediates the development of insulin resistance in animal models and humans has been gaining strong support. It has also been shown that immune cells in local tissues, in particular in visceral adipose tissue, play a major role in the regulation of obesity-induced inflammation. Specifically, obesity increases the numbers and activation of proinflammatory immune cells, including M1 macrophages, neutrophils, Th1 CD4 T cells, and CD8 T cells, while simultaneously suppressing anti-inflammatory cells such as M2 macrophages, CD4 regulatory T cells, regulatory B cells, and eosinophils. Read More

    Comparison of Antidiabetic Regimens in Patients with Type 2 Diabetes Uncontrolled by Combination Therapy of Sulfonylurea and Metformin: Results of the MOHAS Disease Registry in Korea.
    Diabetes Metab J 2017 May 11. Epub 2017 May 11.
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
    Background: The aim of this study was to investigate the glucose-lowering efficacy of antidiabetic treatments in patients with type 2 diabetes mellitus (T2DM) uncontrolled by sulfonylurea plus metformin.

    Methods: This open-label, multicenter, prospective, observational study was conducted in 144 centers in Korea, from June 2008 to July 2010, and included patients with T2DM who had received sulfonylurea and metformin for at least 3 months and had levels of glycosylated hemoglobin (HbA1c) >7.0% in the last month. Read More

    Diabetes Prevention in Australia: 10 Years Results and Experience.
    Diabetes Metab J 2017 Feb 2. Epub 2017 Feb 2.
    Centre for Population Health Research, Deakin University, Melbourne, Australia.
    Clinical trials have demonstrated the efficacy of lifestyle modification for the prevention of type 2 diabetes mellitus but it was achieved at higher cost than can be sustained in routine health services. The first clinical trial to report was the Finnish Diabetes Prevention Study. This paper describes how Australia worked with Finnish colleagues to adapt the findings of that study to achieve a statewide diabetes prevention program. Read More

    The Role of SGLT-2 Inhibitors as Part of Optimal Medical Therapy in Improving Cardiovascular Outcomes in Patients with Diabetes and Coronary Artery Disease.
    Cardiovasc Drugs Ther 2017 May 24. Epub 2017 May 24.
    Peter Munk Cardiac Centre, University Health Network, 585 University Avenue, 4N474, Toronto, ON, M5G 2N2, Canada.
    The optimal treatment approach to patients with coronary artery disease (CAD), including those with type 2 diabetes mellitus (T2DM), has been extensively evaluated. Several trials of stable ischemic heart disease including patients with T2DM have demonstrated that medical management is comparable to revascularization in terms of mortality and rates of major adverse cardiovascular events (MACE). There has been a growing appreciation for optimal medical therapy's (OMT) role in improving clinical outcomes. Read More

    Caution advised with dapagliflozin in the setting of male urinary tract outlet obstruction.
    BMJ Case Rep 2017 May 22;2017. Epub 2017 May 22.
    Endocrinology, Austin Health, Heidelberg, Victoria, Australia.
    We describe an adverse outcome in a 70-year-old man with type 2 diabetes mellitus treated with sodium-glucose cotransporter type 2 (SGLT2) inhibitor dapagliflozin. SGLT2 inhibitors act in the proximal tubules to prevent glucose reabsorption and induce urinary glucose excretion, they have been associated with increased risk of urinary tract infection (UTI). Our patient presented to hospital with Escherichia coli septicaemia with positive urine and blood cultures on the background of two previous UTIs occurring post commencement of dapagliflozin in the community. Read More

    [Association between SORCS1 rs1416406 and therapeutic effect of exenatide].
    Zhonghua Yi Xue Za Zhi 2017 May;97(18):1415-1419
    Department of Endocrinology and Metabolism, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
    Objective: To study the relationship between SORCS1 gene rs1416406 and efficiency of exenatide. Methods: Between August 2010 and August 2012, a hundred and one newly diagnosed patients with type 2 diabetes mellitus (T2DM) were from CONFIDENCE study covering 25 university-affiliated hospitals in 13 provinces of China. All patients received exenatide treatment for 48 weeks. Read More

    Ameliorating effect of anti-Alzheimer's drugs on the bidirectional association between type 2 diabetes mellitus and Alzheimer's disease.
    Exp Biol Med (Maywood) 2017 Jan 1:1535370217711440. Epub 2017 Jan 1.
    4 Drug and Poison Information Specialist, Pharmacy Services, Security Forces Hospital, Riyadh, KSA 11481, Saudi Arabia.
    Mild to severe forms of nervous system damage were exhibited by approximately 60-70% of diabetics. It is important to understand the association between type 2 diabetes mellitus and Alzheimer's disease. The aim of the present work is to understand the bidirectional association between type 2 diabetes and Alzheimer's disease pathogenesis, that was monitored by glycaemic status, lipid profile, amyloid beta 40 and 42 (Aβ40 and Aβ42), C-reactive protein, total creatine kinase, total lactate dehydrogenase, D-dimer and magnesium measurements, to assess the association between theses biochemical markers and each other, to estimate the possibility of utilizing the amyloid beta as biochemical marker of T2D in Alzheimer's patients, and to evaluate the effect of piracetam and memantine drugs on diabetes mellitus. Read More

    National Trends in Bariatric Surgery 2012-2015: Demographics, Procedure Selection, Readmissions, and Cost.
    Obes Surg 2017 May 22. Epub 2017 May 22.
    Department of Surgery, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN, 55455, USA.
    Background: Bariatric surgery is widely accepted as the best treatment for obesity and type 2 diabetes mellitus (T2DM). The Roux-en-Y gastric bypass (RYGB) and the sleeve gastrectomy (SG) have become the predominant bariatric procedures in the USA over the last several years, although the most recent trends in selection are unknown.

    Objective: The objective of this study is to assess selection trends, readmission rates, and cost of bariatric procedures in the USA from 2012 to 2015. Read More

    Protocatechuic Acid, a Phenolic from Sansevieria roxburghiana Leaves, Suppresses Diabetic Cardiomyopathy via Stimulating Glucose Metabolism, Ameliorating Oxidative Stress, and Inhibiting Inflammation.
    Front Pharmacol 2017 8;8:251. Epub 2017 May 8.
    Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur UniversityKolkata, India.
    Persistent hyperglycemia, impairment of redox status and establishment of inflammatory pathophysiology integrally play important role in the pathogenesis of diabetic cardiomyopathy (DC). Present study examined the therapeutic potential of protocatechuic acid isolated from the Sansevieria roxburghiana rhizomes against DC employing rodent model of type 2 diabetes (T2D). T2D was induced by high fat diet + a low-single dose of streptozotocin (35 mg/kg, i. Read More

    A retrospective cohort study on the risk of stroke in relation to a priori health knowledge level among people with type 2 diabetes mellitus in Taiwan.
    BMC Cardiovasc Disord 2017 May 22;17(1):130. Epub 2017 May 22.
    Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan.
    Background: Intervention of diabetes care education with regular laboratory check-up in outpatient visits showed long-term benefits to reduce the risk of macrovascular complications among people with type 2 diabetes. However, research on the level of a priori health knowledge to the prevention of diabetic complications in community settings has been scarce. We therefore aimed to investigate the association of health knowledge and stroke incidence in patients with type 2 diabetes in Taiwan. Read More

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