128,199 results match your criteria Diabetes Mellitus Type 2

The Role of Triglyceride Glucose Index in Development of Type 2 Diabetes Mellitus.

Diabetes Res Clin Pract 2018 Jun 21. Epub 2018 Jun 21.

Family and Community Medicine, Khoo Teck Puat Hospital, Singapore.

Aims: Triglyceride-Glucose (TyG) is an emerging surrogate indicator of insulin resistance. We explored the role of TyG in development of Type 2 Diabetes Mellitus(T2DM) and elucidated the mechanism for the relationship.

Methods: 4109 subjects without baseline T2DM participated in a community screening programme in 2013-2016. Read More

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Potential impact of Helicobacter pylori-related metabolic syndrome on upper and lower gastrointestinal tract oncogenesis.

Metabolism 2018 Jun 21. Epub 2018 Jun 21.

Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Both Helicobacter pylori infection and metabolic syndrome present significant global public health burdens. Metabolic syndrome is closely related to insulin resistance, the major underlying mechanism responsible for metabolic abnormalities, and Helicobacter pylori infection has been proposed to be a contributing factor. There is growing evidence for a potential association between Helicobacter pylori infection and insulin resistance, metabolic syndrome and related morbidity, including abdominal obesity, type 2 diabetes mellitus, dyslipidemia, hypertension, all of which increase mortality related to cardio-cerebrovascular disease, neurodegenerative disorders, nonalcoholic fatty liver disease and malignancies. Read More

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Neuroprotective effect of epalrestat mediated through oxidative stress markers, cytokines and TAU protein levels in diabetic rats.

Life Sci 2018 Jun 21. Epub 2018 Jun 21.

Dr. Prabhakar Kore Basic Science Research Center, KLE Academy of Higher Education and Research (KLE University), Nehru Nagar, Belagavi, Karnataka, India.

Aims: Type-2 diabetes mellitus (DM) is associated with cognitive impairment. Increasing evidence establishes that neuro-inflammatory and oxidative stress condition plays a main role in the development of neurodegeneration. Epalrestat, an aldose reductase inhibitor is commonly prescribed for the treatment of diabetic peripheral neuropathy. Read More

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Liver Enzymes, Fatty Liver and Type 2 Diabetes Mellitus in a Jinchang Cohort: A Prospective Study in Adults.

Can J Diabetes 2018 Feb 13. Epub 2018 Feb 13.

Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, People's Republic of China.

Objectives: It is unclear whether liver enzymes or the interactions of various liver enzymes is a predictor of type 2 diabetes mellitus (T2DM), which is independent of fatty liver.

Methods: A total of 48,001 subjects participated in baseline examinations. Among the subjects, 33,355 were followed for an average of 2. Read More

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February 2018

Unmet Need for Adjunctive Dyslipidemia Therapy in Hypertriglyceridemia Management.

J Am Coll Cardiol 2018 Jun 16. Epub 2018 Jun 16.

VA New England Healthcare System, Boston University School of Medicine, Boston, Massachusetts.

Despite the important role of high-intensity statins in reducing atherosclerotic cardiovascular disease events in secondary and primary prevention, substantial residual risk persists, particularly among high-risk patients with type 2 diabetes mellitus, metabolic syndrome, and obesity. Considerable attention is currently directed to the role that elevated triglycerides (TGs) and non-high-density lipoprotein cholesterol levels play as important mediators of residual atherosclerotic cardiovascular disease risk, which is further strongly supported by genetic linkage studies. Previous trials with fibrates, niacin, and most cholesterol ester transfer protein inhibitors that targeted high-density lipoprotein cholesterol raising, and/or TG lowering, have failed to show conclusive evidence of incremental event reduction after low-density lipoprotein cholesterol levels were "optimally controlled" with statins. Read More

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Effects of Canagliflozin on Fatty Liver Indexes in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials.

J Pharm Pharm Sci 2018 ;21(1):222-235

Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Purpose: Non-alcoholic fatty liver disease (NAFLD) affects about 75% of patients with type 2 diabetes mellitus (T2DM). We conducted a meta-analysis to determine the effect of canagliflozin on fatty liver indexes in T2DM patients.

Methods: A literature search of PubMed, Embase and Cochrane was conducted up to March 30, 2017. Read More

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January 2018

Association between sodium glucose co-transporter 2 inhibitors and a reduced risk of heart failure in patients with type 2 diabetes mellitus: a real-world nationwide population-based cohort study.

Cardiovasc Diabetol 2018 Jun 23;17(1):91. Epub 2018 Jun 23.

Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.

Background: Recently, two large randomized controlled trials which only included patients with underlying cardiovascular disease (CVD) or patients at high risk for CVD showed that two sodium glucose co-transporter 2 inhibitors (SGLT-2is) significantly reduced hospitalization for heart failure (hHF), with an early separation in the survival curves for hHF. There were concerns whether SGLT-2i use could protect hHF in patients without CVD and how soon SGLT-2i-treated patients show a lower risk of hHF. Thus, we aimed to evaluate whether the heart failure protective effect of SGLT-2i differs depending on the underlying CVD and the prescription period compared with dipeptidyl peptidase-4 inhibitors (DPP-4i). Read More

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Hipoglicemiantes Orais Para Diabetes Mellitus Tipo 2: Comparação de Preços no Brasil e em Outros Sistemas Universais de Saúde.

Value Health Reg Issues 2018 Jun 20;17:135-141. Epub 2018 Jun 20.

Federal University of Minas Gerais, Faculty of Pharmacy, Belo Horizonte, MG, Brazil.

Objectives: To estimate the average price of oral hypoglycemic agents provided by the Brazilian health system (SUS) and to compare them to other public health systems.

Methods: Cross-sectional study about drug prices purchased by Belo Horizonte (municipal level), Minas Gerais (state level) and federal institutions in January and February of 2014. Average prices were calculated by defined daily dosage (DDD) and were compared to the management levels and the program "Aqui Tem Farmácia Popular" (ATFP). Read More

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Metformin inhibits TGF-beta 1-induced MCP-1 expression through BAMBI-mediated suppression of MEK/ERK1/2 signaling.

Nephrology (Carlton) 2018 Jun 22. Epub 2018 Jun 22.

Research center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, 510120.

Aims: Metformin is a biguanide derivative widely used for the treatment of type 2 diabetes mellitus. Recent evidence implicates that this anti-hyperglycemic drug exerts renal protective effects, yet the mechanisms remain poorly understood. MCP-1 has been recognized as a key mediator of renal fibrosis in chronic kidney diseases including diabetic nephropathy. Read More

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A new experience for incorrect insulin administration.

Acta Diabetol 2018 Jun 22. Epub 2018 Jun 22.

Division of Endocrinology and Metabolism, Internal Medicine Department, Faculty of Medicine, Selcuk University, Konya, Turkey.

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June 2018
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Norepinephrine augmented in vitro growth of uropathogenic E. coli in Type 2 diabetes mellitus and its suppression by silodosin (alpha blocker).

Diagn Microbiol Infect Dis 2018 May 30. Epub 2018 May 30.

Department of Endocrinology and Metabolism, Institute of Medical Sciences Banaras Hindu University Varanasi, India. Electronic address:

Norepinephrine is secreted under conditions of stress in humans. The ability of bacteria to sense mammalian hormone may have a role in propagation of infection. The present study investigated the effect of norepinephrine on in vitro growth of uropathogenic E. Read More

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Safety and efficacy of bariatric surgery in Mexico: A detailed analysis of 500 surgeries performed at a high-volume center.

Rev Gastroenterol Mex 2018 Jun 19. Epub 2018 Jun 19.

Clínica Integral de Cirugía para la Obesidad y Enfermedades Metabólicas del Hospital General Tláhuac, Ciudad de México, México. Electronic address:

Introduction And Objectives: Bariatric surgery is the best method for treating obesity and its comorbidities. Our aim was to provide a detailed analysis of the perioperative outcomes in Mexican patients that underwent surgery at a high-volume hospital center.

Materials And Methods: A retrospective study was conducted on all the patients that underwent bariatric surgery at a single hospital center within a time frame of 4 and one-half years. Read More

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A case risk study of lactic acidosis risk by metformin use in type 2 diabetes mellitus tuberculosis coinfection patients.

Indian J Tuberc 2018 Jul 3;65(3):252-256. Epub 2017 Jun 3.

Department of Clinical Microbology, Faculty of Medicine Airlangga University/Dr. Soetomo Hospital, Indonesia.

Metformin (MET) has possibilities to be utilized as an adjunct of tuberculosis (TB) therapy for controlling the growth of Mycobacterium tuberculosis (M. tuberculosis). MET enhances the production of mitochondrial reactive oxygen species and facilitates phagosome-lysosome fusion; those mechanism are important in M. Read More

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Effects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetes.

Gynecol Endocrinol 2018 Jun 22:1-5. Epub 2018 Jun 22.

d Endocrinology and Metabolism Research Center, Department of Biochemistry and Genetics, School of Medicine , Arak University of Medical Sciences , Arak , Iran.

Patients with type 2 diabetes mellitus (T2DM) have been known to be suffering from coenzyme Q10 (CoQ10) deficiency which results in some complications in them. The purpose of this clinical trial study was to evaluate the effects of CoQ10 supplementation on serum values of adiponectin (A), leptin (L), 8-isoprostane, malondialdehyde (MDA), the A/L ratio in women with T2DM. Sixty-eight women with T2DM were enrolled in the current study and were randomly divided into drug (n = 34) and placebo (n = 34) groups who were consuming 100 mg CoQ10 and 100 mg cellulose acetate per day for 12 weeks, respectively. Read More

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[Hypolipidemic effect of Coptis chinensis and C. deltoidea on type 2 diabetes rats through SCAP/SREBP-1c signal pathway].

Zhongguo Zhong Yao Za Zhi 2018 May;43(10):2129-2133

Medical College, Southwest Jaotong University, Chengdu 610031, China.

The type 2 diabetes rat model was induced with high-sugar and high-fat diet combined with low-dose STZ. This study investigated the hypolipidemic mechanism of Coptis chinensis and C. deltoidea. Read More

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Factors Associated With Inadequate Intraoperative Baseline Lower Extremity Somatosensory Evoked Potentials.

J Clin Neurophysiol 2018 Jun 21. Epub 2018 Jun 21.

Division of Intraoperative Neurophysiological Monitoring, Keck Hospital of University of Southern California, Los Angeles, California, U.S.A.

Purpose: Intraoperative neurophysiologic monitoring involves the use of various modalities, including somatosensory evoked potentials (SEP), to assess the integrity of the at-risk nervous system during surgeries. Reliable baseline tracings are important because they are data against which future tracings are compared to detect potential injury. In some cases, adequate baselines may be difficult to achieve. Read More

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Improving Glycemic Control in a Geriatric Population.

J Natl Black Nurses Assoc 2017 Jul;28(1):24-30

This quality improvement project evaluated whether offering a series of 5 structured interdisciplinary diabetic educational teaching sessions would improve glycemic control as measured by random blood sugars (RBS) in a Program of All-Inclusive Care for the Elderly (PACE). Five diabetic educational sessions were held over a 4-week period with 50 participants (N = 50). Data were analyzed and displayed using descriptive statistics and figures. Read More

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Correlations between plasma strontium concentration, components of calcium and phosphate metabolism and renal function in type 2 diabetes mellitus.

Eur J Clin Invest 2018 Jun 21:e12987. Epub 2018 Jun 21.

Department of Internal Medicine/Nephrology, ZGT Hospital, Almelo and Hengelo, The Netherlands.

Background: Renal function decline in diabetic kidney disease is accompanied by calcium and phosphate metabolism alterations. Whereas Strontium (Sr ) has many similarities with calcium, little is known about Sr in this respect. We studied the association of plasma Sr concentration and parameters associated with an altered calcium and phosphate metabolism in diabetic kidney disease. Read More

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June 2018
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Hypoglycemia Among Patients with Type 2 Diabetes: Epidemiology, Risk Factors, and Prevention Strategies.

Curr Diab Rep 2018 Jun 21;18(8):53. Epub 2018 Jun 21.

Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Purpose Of Review: Hypoglycemia is the most common and often treatment-limiting serious adverse effect of diabetes therapy. Despite being potentially preventable, hypoglycemia in type 2 diabetes incurs substantial personal and societal burden. We review the epidemiology of hypoglycemia in type 2 diabetes, discuss key risk factors, and introduce potential prevention strategies. Read More

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June 2018
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There is a Close Association Between the Recovery of Liver Injury and Glycemic Control after SGLT2 Inhibitor Treatment in Japanese Subjects with Type 2 Diabetes: A Retrospective Clinical Study.

Diabetes Ther 2018 Jun 21. Epub 2018 Jun 21.

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Kurashiki, Japan.

Introduction: Sodium-glucose co-transporter 2 (SGLT2) inhibitors function not only to reduce hyperglycemia but also to ameliorate liver injury and reduce body weight. The aim of this study was to examine in which subjects SGLT2 inhibitors are more effective for glycemic control, liver injury, and obesity in Japanese subjects with type 2 diabetes mellitus.

Methods: We enrolled a total of 156 subjects with type 2 diabetes who initiated SGLT2 inhibitor treatment after September 1, 2014 in Kawasaki Medical School (Protocol No. Read More

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June 2018
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Discrepancies Between BMI and Classic Cardiovascular Risk Factors.

Obes Surg 2018 Jun 21. Epub 2018 Jun 21.

Department of Internal Medicine, Franciscus Gasthuis, PO Box 10900, 3004 BA, Rotterdam, The Netherlands.

Background: Obesity is related to increased cardiovascular risk. It is unknown whether increasing levels of obesity also increase levels of cardiovascular risk factors and systemic inflammation. This study describes the relationship between classic cardiovascular risk factors and inflammatory markers with BMI in a group of obese and non-obese subjects. Read More

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June 2018
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Micro R-410 Binding Site Single Nucleotide Polymorphism rs13702 in Lipoprotein Lipase Gene is Effective to Increase Susceptibility to Type 2 Diabetes in Iranian Population.

Adv Biomed Res 2018 23;7:79. Epub 2018 May 23.

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The relationship between dyslipidemia and type 2 diabetes mellitus (T2DM) has been frequently reported. Lipoprotein lipase (LPL) is considered to be an effective gene in regulating lipid profile. MicroRNAs (miRNAs) are small noncoding RNAs involved in posttranscriptional regulation of gene expression. Read More

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Identification of four genes as novel susceptibility loci for early-onset type 2 diabetes mellitus, metabolic syndrome, or hyperuricemia.

Biomed Rep 2018 Jul 29;9(1):21-36. Epub 2018 May 29.

CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.

Given that early-onset type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), and hyperuricemia have been shown to have strong genetic components, the statistical power of a genetic association study may be increased by focusing on early-onset subjects with these conditions. Although genome-wide association studies have identified various genes and loci significantly associated with T2DM, MetS, and hyperuricemia, genetic variants that contribute to predisposition to these conditions in Japanese subjects remain to be identified definitively. We performed exome-wide association studies (EWASs) for early-onset T2DM, MetS, or hyperuricemia to identify genetic variants that confer susceptibility to these conditions. Read More

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Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.

Arterioscler Thromb Vasc Biol 2018 Jun 21. Epub 2018 Jun 21.

From the Department of Laboratory Medicine and Pathobiology (M.L., M.H.W., A.S.R., D.N., N.S., G.H., M.P.B.)

Objective: Vascular calcification is a common and severe complication in patients with atherosclerosis which is exacerbated by type 2 diabetes mellitus. Our laboratory recently reported that the collagen receptor discoidin domain receptor 1 (DDR1) mediates vascular calcification in atherosclerosis; however, the underlying mechanisms are unknown. During calcification, vascular smooth muscle cells transdifferentiate into osteoblast-like cells, in a process driven by the transcription factor RUNX2 (runt-related transcription factor 2). Read More

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Internal diseases encountered by dental students while treating dental patients during undergraduate training.

BMC Med Educ 2018 Jun 22;18(1):149. Epub 2018 Jun 22.

III. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Background: The number of internal diseases, disorders and syndromes (IMDDSs) encountered in dental practice is increasing. Dentists report to feel ill prepared by their undergraduate dental training for the management of IMDDSs. To increase the effectiveness of internal medicine training at dental school it might be necessary to focus on IMDDs encountered by dental students. Read More

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Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-κB Pathway.

Front Pharmacol 2018 6;9:598. Epub 2018 Jun 6.

Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

The anti-inflammatory and antioxidant capacity of carnosine (CAR) has been investigated in autoimmune diseases. The aim of this study was to evaluate the potential protective effects of oral CAR supplements to ameliorate type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and its mechanism. Seventy male Sprague-Dawley rats were randomly divided into the control group (CG, = 10) and the T2DM group ( = 60). Read More

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June 2018
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Efficacy of epalrestat plus α-lipoic acid combination therapy monotherapy in patients with diabetic peripheral neuropathy: a meta-analysis of 20 randomized controlled trials.

Neural Regen Res 2018 Jun;13(6):1087-1095

Runliang Diabetes Laboratory, Diabetes Research Center, Ningbo University; Medical School, Ningbo University, Ningbo, Zhejiang Province, China.

Objective: To evaluate the efficacy of α-lipoic acid (ALA) plus epalrestat combination therapy in the treatment of diabetic peripheral neuropathy (DPN).

Data Sources: The electronic databases of PubMed, Medline, Embase, the Cochrane Library, the Chinese National Knowledge Infrastructure, the Wanfang Database and the Chinese Biomedical Database were used to retrieve relevant studies without language restrictions. The search was conducted from the inception of each database to 7 October 2016. Read More

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June 2018
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[Effects of aerobic exercise and dieting on chemerin and its receptor CMKLR1 in the livers of type 2 diabetic rats].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2017 May;33(5):426-430

School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.

Objective: To investigate the effects of aerobic exercise and dieting on chemerin and its receptor chemokine like receptor-1 (CMKLR1) in the livers of type 2 diabetes mellitus (DM) rats and its possible roles on the improvements of blood glucose and lipid metabolism.

Methods: Fifty male SD rats were randomly divided into control group (Con, =6) fed with normal diet and DM model group (=44) fed with high fat diet. After 8-week feeding, DM model rats were intraperitoneal injected streptozocin (STZ) at the dose of 30 mg/kg body weight to establish DM rats. Read More

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May 2017
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MEDI0382, a GLP-1-glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomised, phase 1 study.

Br J Clin Pharmacol 2018 Jun 21. Epub 2018 Jun 21.

Cardiovascular, Renal, and Metabolism iMED, MedImmune Inc, Gaithersburg, MD, USA.

Aims: MEDI0382 is a balanced glucagon-like peptide-1/glucagon receptor dual agonist under development for the treatment of type 2 diabetes mellitus and non-alcoholic steatohepatitis. The primary objective was to assess the safety of MEDI0382 in healthy subjects.

Methods: In this placebo-controlled, double-blind, phase 1 study, healthy subjects (aged 18-45 years) were randomised (3:1) to receive a single subcutaneous dose of MEDI0382 or placebo after ≥8 hours of fasting. Read More

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June 2018
2 Reads

Ipragliflozin Add-on Therapy to a GLP-1 Receptor Agonist in Japanese Patients with Type 2 Diabetes (AGATE): A 52-Week Open-Label Study.

Diabetes Ther 2018 Jun 20. Epub 2018 Jun 20.

Astellas Pharma Inc., 2-5-1 Nihonbashi-Honcho Chuo-ku, Tokyo, 103-8411, Japan.

Introduction: Few data are available regarding ipragliflozin treatment in combination with glucagon-like peptide-1 (GLP-1) receptor agonists. The aim of this study was to evaluate the efficacy and safety of ipragliflozin in combination with GLP-1 receptor agonists in Japanese patients with inadequately controlled type 2 diabetes mellitus (T2DM).

Methods: This multicenter study (consisting of three periods: a 4-week washout period, a 6-week observation period, and a 52-week open-label treatment period) included patients aged ≥ 20 years who received a stable dose/regimen of a GLP-1 receptor agonist either solely or in combination therapy with a sulfonylurea for ≥ 6 weeks, with glycosylated hemoglobin (HbA1c) of ≥ 7. Read More

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Beneficial metabolic effects of 2', 3', 5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine in multiple biological matrices and intestinal flora of hyperlipidemic hamsters.

J Proteome Res 2018 Jun 21. Epub 2018 Jun 21.

ABSTRACT:Hyperlipidemia is one of the main causes of obesity, type 2 diabetes mellitus (T2DM) and atherosclerosis. The adenosine derivative, 2', 3', 5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine (IMM-H007) is an effective lipid-lowering compound that has important implications for the development of lipid-lowering drugs. Metabolomic analysis based on 1H-NMR was used to monitor dynamic changes in diverse biological media including serum, liver, urine, and feces in response to high-fat diet (HFD) and IMM-H007 treatments. Read More

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Food restriction promotes damage reduction in rat models of type 2 diabetes mellitus.

PLoS One 2018 20;13(6):e0199479. Epub 2018 Jun 20.

Department of Morphological Sciences, State University of Maringá, Paraná, Brazil.

There are several animal models of type 2 diabetes mellitus induction but the comparison between models is scarce. Food restriction generates benefits, such as reducing oxidative stress, but there are few studies on its effects on diabetes. The objective of this study is to evaluate the differences in physiological and biochemical parameters between diabetes models and their responses to food restriction. Read More

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Efficacy and Safety of the Glucagon Receptor Antagonist PF-06291874: A 12-Week, Randomized, Dose-Response Study in Patients With Type 2 Diabetes Mellitus on Background Metformin Therapy.

Diabetes Obes Metab 2018 Jun 19. Epub 2018 Jun 19.

Pfizer Inc, Cambridge, MA, USA.

Aims: To conduct a dose-response assessment of the efficacy and safety of the glucagon receptor antagonist PF-06291874 in adults with type 2 diabetes (T2DM) receiving stable doses of metformin.

Materials And Methods: This randomized, double-blind, statin-stratified, placebo-controlled, 4-arm, parallel-group study was conducted in patients with T2DM receiving background metformin. After an 8-week, non-metformin oral antidiabetic agent washout period, 206 patients were randomized to placebo or PF-06291874 (30, 60, or 100 mg once daily) for 12 weeks. Read More

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The Cardiovascular Benefits Associated with the Use of Sodium-Glucose Cotransporter 2 Inhibitors - Real-World Data.

Gallwitz Baptist

Eur Endocrinol 2018 Apr 18;14(1):17-23. Epub 2018 Apr 18.

Medizinische Klinik IV, University of Tübingen, Tübingen, Germany.

Type 2 diabetes (T2D) is associated with numerous comorbidities that significantly reduce quality of life, increase mortality and complicate treatment decisions. In a recent cardiovascular outcomes trial, Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME), the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin was shown to reduce cardiovascular (CV) mortality and heart failure in high-risk patients with T2D with a previous CV event or with established CV disease (CVD). Recently published data from the Canagliflozin Cardiovascular Assessment Study (CANVAS-PROGRAM) study suggested that the cardiovascular benefits of empagliflozin are also seen with the SGLT2-inhibitor canagliflozin, indicating a class effect of SGLT2 inhibitors. Read More

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April 2018
2 Reads

Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status.

Front Endocrinol (Lausanne) 2018 25;9:172. Epub 2018 Apr 25.

Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Metabolic surgery is superior to lifestyle intervention in reducing weight and lowering glycemia and recently suggested as treatment for type 2 diabetes mellitus. Especially Roux-en-Y gastric bypass (RYGB) has been focus for much research, but still the mechanisms of action are only partly elucidated. We suggest that several mechanisms might be mediated by sphingolipids like sphingomyelin. Read More

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April 2018
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How do Saudi diabetic patients perceive their illness? A multicenter survey using revised-illness perception questionnaire.

J Family Community Med 2018 May-Aug;25(2):75-81

Department of Undergraduate Medical Students, College of Medicine, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.

Background: Illness perception questionnaires for various medical conditions have become more useful in recent years. However, very few have used this to address the issue of type 2 diabetes in Saudi Arabia.

Materials And Methods: This study was conducted among type 2 diabetic patients attending primary healthcare centers and Al Kharj Military Industries Corporation Hospital in Al Kharj, Saudi Arabia, during November 24, 2016, to April 24, 2017. Read More

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Diagnosis and follow-up of type 2 diabetes in women with PCOS. A role of OGTT?

Eur J Endocrinol 2018 Jun 19. Epub 2018 Jun 19.

D Glintborg, Endocrinology, Odense University Hospital, Odense , DK-5000, Denmark.

Polycystic ovary syndrome (PCOS) is common in premenopausal women. The majority of women with PCOS have insulin resistance and the risk of type 2 diabetes mellitus (T2D) is higher in women with PCOS compared to controls. In non-pregnant women with PCOS, glycemic status may be assessed by oral glucose tolerance test (OGTT), fasting plasma glucose (FPG), or HbA1c. Read More

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Dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid: a retrospective study of 168 pemphigoid and 9,304 diabetes mellitus cases.

J Diabetes Investig 2018 Jun 19. Epub 2018 Jun 19.

Department of Diabetology and Nephrology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.

Aim/introduction: Bullous pemphigoid (BP) may be drug-induced. This study evaluated the relation between BP and dipeptidyl peptidase-4 inhibitors (DPP4Is).

Materials And Methods: We recruited patients diagnosed with BP at Ogaki Municipal Hospital from December 1, 2009 through December 31, 2017. Read More

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June 2018
2 Reads

Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction.

PLoS One 2018 19;13(6):e0199207. Epub 2018 Jun 19.

Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.

A growing body of evidence suggests a protective role of polyphenols and exercise training on the disorders of type 2 diabetes mellitus (T2DM). We aimed to assess the effect of the açaí seed extract (ASE) associated with exercise training on diabetic complications induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type 2 diabetes was induced by feeding rats with HF diet (55% fat) for 5 weeks and a single dose of STZ (35 mg/kg i. Read More

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June 2018
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Clinical utility of bone markers in various diseases.

Bone 2018 Jun 16. Epub 2018 Jun 16.

Department of Clinical Chemistry, Endocrine Laboratory, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Electronic address:

Measurements of bone markers (BMs) in peripheral blood or urine are a pivotal part of bone research within modern clinical medicine. In recent years the use of BMs increased substantially as they can be useful either to diagnose bone (related) disease and to follow its natural history, but also to monitor the effects of interventions. However, the use of BMs is still complicated mainly due to (pre)analytical variability of these substances, limited accessibility of assays, variable cut-off values in different countries and laboratories and heterogeneous results with regard to clinical implications of measuring BMs in several studies. Read More

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DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA.

Brain Behav Immun 2018 Jun 16. Epub 2018 Jun 16.

Respiratory Department, Tianjin Medical University General Hospital, Tianjin Medical University, 300052 Tianjin, China. Electronic address:

Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice (C57 mice) underwent IH or normoxia (control) exposure for 4 weeks. Read More

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June 2018
2 Reads

Exposure to hypoglycemia and risk of stroke.

Ann N Y Acad Sci 2018 Jun 19. Epub 2018 Jun 19.

Cerebral Vascular Disease Research Laboratories, University of Miami, Miami, Florida.

In the treatment of both type 1 and type 2 diabetes mellitus, maintaining a euglycemic state represents one of the key challenges. Improper dosing and administration of glucose-lowering drugs is associated with an increased risk of recurrent hypoglycemia episodes. In addition, the risk of adverse cardiovascular events in diabetic patients, particularly myocardial infarctions and strokes, is well established. Read More

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June 2018
3 Reads

Efficacy and safety of dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes mellitus patients with moderate to severe renal impairment: a meta-analysis.

Eur Rev Med Pharmacol Sci 2018 Jun;22(11):3502-3514

Department of Endocrinology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Objective: Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agents for type 2 diabetes mellitus (T2DM) patients. However, the effects and safety of DPP-4 inhibitors in T2DM patients with renal impairment (RI) remain controversial. Therefore, we conducted this meta-analysis to assess the efficacy and safety of DPP-4 inhibitors in T2DM patients with moderate to severe RI. Read More

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June 2018
2 Reads

Pancreas transplantation in type 2 diabetes: expanding the criteria.

Curr Opin Organ Transplant 2018 Jun 18. Epub 2018 Jun 18.

Department of Surgery, Division of Transplantation, University of Wisconsin Hospital and Clinics Inc, Madison, Wisconsin, USA.

Purpose Of Review: Pancreas transplantation in type 2 diabetes mellitus (T2DM) candidates remains disproportionately lower than in type 1 diabetes mellitus (T1DM); however, outcomes in carefully selected patients mirrors that of T1DM. Despite the 2014 United Network for Organ Sharing (UNOS) eligibility criteria for simultaneous pancreas/kidney transplant (SPK) transplantation in T2DM patients, an expected increase in the number of transplants was not observed.

Recent Findings: In an updated International Pancreas and Transplant Registry (IPTR) analysis, 1514 primary deceased donor pancreas transplants were performed in T2DM recipients [1995-2015, SPK 88%, pancreas after kidney (PAK) 9%, pancreas transplant alone (PTA) 3%]. Read More

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Combined SGLT1 and SGLT2 Inhibitors and Their Role in Diabetes Care.

Diabetes Technol Ther 2018 Jun;20(S2):S269-S277

Diabetes Center for Children and Adolescents Kinder- und Jugendkrankenhaus AUF DER BULT, Hannover, Germany .

The sodium-glucose cotransporter type 1 (SGLT1) is the primary transporter for absorption of glucose and galactose in the gastrointestinal tract. Inhibition blunts and delays postprandial glucose (PPG) excursion. Sodium-glucose cotransporter type 2 (SGLT2) is expressed in the kidney, where it reabsorbs 90% of filtered glucose. Read More

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June 2018
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Liraglutide improves cognitive impairment via the AMPK and PI3K/Akt signaling pathways in type 2 diabetic rats.

Mol Med Rep 2018 Jun 18. Epub 2018 Jun 18.

Second Department of Endocrinology, Tangshan Gongren Hospital, Tangshan, Hebei 063000, P.R. China.

Liraglutide is a type of glucagon‑like‑peptide 1 receptor agonist, which has been reported as a novel type of antidiabetic agent with numerous benefits, including cardiovascular and neuroprotective effects. To the best of our knowledge, few studies to date have reported the potential mechanism underlying the neuroprotective effects of liraglutide on rats with type 2 diabetes mellitus (T2DM). The present study aimed to investigate the neuroprotective actions of liraglutide in diabetic rats and to determine the mechanisms underlying these effects. Read More

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miR‑6835‑3p regulates the function of pancreatic islet cells by modulating the expression of AdipoR1.

Int J Mol Med 2018 Jun 15. Epub 2018 Jun 15.

Department of Cardiac Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Effective drugs and strategies for treating type 2 diabetes mellitus (2‑DM) are urgently required. The aim of the present study was to elucidate the mechanism underlying microRNA (miR)‑6835‑3p regulation of adiponectin receptor 1 (AdipoR1) expression and the miR‑6835‑3p/AdipoR1 signaling pathway in pancreatic islet cells. In addition, the potential anti‑diabetes effect of miR‑6835‑3p on insulin secretion was investigated. Read More

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June 2018
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Emphysematous pyelonephritis and cystitis: A case report and literature review.

J Int Med Res 2018 Jan 1:300060518770341. Epub 2018 Jan 1.

1 Department of Urology, First Hospital of Jilin University, Changchun, Jilin Province, China.

This present case report describes a 64-year-old female patient with type 2 diabetes mellitus who also had emphysematous pyelonephritis (EPN) and emphysematous cystitis (EC). Computed tomography revealed well defined emphysematous pyelonephritis and cystitis. Broad-spectrum antibiotic and percutaneous drainage of the right kidney were used as part of a conservative management regimen. Read More

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January 2018
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Intestinal Glucose Absorption Was Reduced by Vertical Sleeve Gastrectomy via Decreased Gastric Leptin Secretion.

Obes Surg 2018 Jun 18. Epub 2018 Jun 18.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan, 430022, China.

Background: The unique effects of gastric resection after vertical sleeve gastrectomy (VSG) on type 2 diabetes mellitus remain unclear. This work aimed to investigate the effects of VSG on gastric leptin expression and intestinal glucose absorption in high-fat diet-induced obesity.

Methods: Male C57BL/6J mice were fed a high-fat diet (HFD) to induce obesity. Read More

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