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    Prediction of a new body shape index and body adiposity estimator for development of type 2 diabetes mellitus: The Rural Chinese Cohort Study.
    Br J Nutr 2017 Nov 16:1-6. Epub 2017 Nov 16.
    1Department of Preventive Medicine,Shenzhen University Health Sciences Center,3688 Nanhai Avenue,Shenzhen,Guangdong 518060,People's Republic of China.
    To compare the ability of a body shape index (ABSI) and body adiposity estimator (BAE) to BMI, waist circumference (WC) and waist:height ratio (WHtR) for predicting development of type 2 diabetes mellitus (T2DM) in rural adult Chinese. The prospective cohort study included 11 687 eligible participants who were free of T2DM at baseline. The risk of new-onset T2DM for ABSI, BAE, BMI, WC and WHtR quintiles was estimated by Cox proportional-hazards regression at follow-up. Read More

    Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease.
    Kidney Int Rep 2017 May 16;2(3):470-480. Epub 2016 Dec 16.
    Diabetes Centre, Khoo Teck Puat Hospital, Singapore.
    Introduction: Pathophysiology of diabetic kidney disease (DKD) is incompletely understood. We aim to elucidate metabolic abnormalities associated with DKD in type 2 diabetes mellitus (T2DM) by targeted plasma metabolomics.

    Methods: A total of 126 T2DM participants with early DKD (urinary albumin-to-creatinine ratio [ACR] 30-299 mg/g and eGFR ≥ 60 ml/min/1. Read More

    Frequency of Type-2 diabetes mellitus in Nephropathic patients and comparison of mean magnesium levels in Nephropathic patients with and without Type-2 diabetes mellitus.
    Pak J Med Sci 2017 Sep-Oct;33(5):1254-1259
    Uzma Malik, Department of Medicine, Mayo Hospital, Lahore, Pakistan.
    Objective: The objective of this study was to determine the frequency of Type 2 diabetes mellitus (T2DM) in patients with nephropathy (i.e. Chronic Kidney Disease Stage 1 to 3) and to compare the mean magnesium levels in diabetic nephropathic patients and non-diabetic nephropathic patients. Read More

    Unusual Salmonella typhi periprosthetic joint infection involving bilateral knees: management options and literature review.
    BMJ Case Rep 2017 Nov 14;2017. Epub 2017 Nov 14.
    Department of Microbiology, Fortis Escorts Heart Institute, New Delhi, Delhi, India.
    A 70-year-old Indian woman, who had undergone primary bilateral total knee arthroplasty (TKA) for rheumatoid arthritis 10 months prior, presented with 10 days history of pain, swelling and erythema over both knees with pus discharging from the right knee. She had type 2 diabetes mellitus and was on long-term steroid, leflunomide and antitumour necrosis factor therapy for rheumatoid arthritis. Her clinical and laboratory features were suggestive of a haematogenous periprosthetic joint infection (PJI). Read More

    Association of dietary patterns with diabetes complications among type 2 diabetes patients in Gaza Strip, Palestine: a cross sectional study.
    J Health Popul Nutr 2017 Nov 15;36(1):37. Epub 2017 Nov 15.
    Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, International Campus (TUMS- IC), Tehran, Iran.
    Background: The prevalence of diabetes mellitus is rising worldwide. When diabetes is uncontrolled, it has dire consequences for health and well-being. However, the role of diet in the origin of diabetes complications is not understood well. Read More

    Safety and efficacy of metformin up-titration in Japanese patients with type 2 diabetes mellitus treated with vildagliptin and low-dose metformin.
    Expert Opin Pharmacother 2017 Nov 15:1-8. Epub 2017 Nov 15.
    a Department of Metabolism & Endocrinology , Juntendo University Graduate School of Medicine , Tokyo , Japan.
    Background: This study investigated the safety and efficacy of metformin up-titration in Japanese patients with type 2 diabetes mellitus treated with vildagliptin (100 mg/day) and low-dose metformin (500 or 750 mg/day).

    Research Design And Methods: Fifty patients were randomly allocated to the control group (maintaining the initial low-dose of metformin) and the dose increase group (up-titrating of metformin to 1,500-2,250 mg/day) for 24 weeks. The primary outcome was change in HbA1c from baseline to 24 weeks. Read More

    Diabetes area patent participation analysis - Part II: Years 2011-2016.
    Expert Opin Ther Pat 2017 Nov 15. Epub 2017 Nov 15.
    a Worldwide Research and Development , Pfizer Inc., 1 Portland St., Cambridge , MA 02139.
    Introduction: Diabetes is a metabolic disease characterized by elevated levels of plasma glucose. When untreated, diabetes increases the risk of developing co-morbidities such as cardiovascular disease. Several drugs, often used as part of combination therapies, have been approved to treat the disease, but these drugs will eventually fail to effectively control blood glucose levels, at which point insulin replacement therapy is required. Read More

    Statin use and risk for type 2 diabetes: what clinicians should know.
    Postgrad Med 2017 Nov 15. Epub 2017 Nov 15.
    b MB Clinical Research , Boca Raton , Florida , United States.
    Statins are the first line of pharmacologic treatment for the management of hypercholesterolemia in patients at risk for atherosclerotic cardiovascular (CV) disease. In recent years, several randomized, controlled trials (RCTs) and observational studies have reported increased risk for new-onset type 2 diabetes mellitus (T2D) with statin treatment, particularly with use of high-intensity statins that reduce low-density lipoprotein cholesterol (LDL-C) by 50% or more. This paper summarizes the data from RCTs and observational studies for statin-associated T2D risk, and puts into perspective this evidence, weighed against the established benefits of statin therapy for CV risk reduction. Read More

    Design of a 24-week trial of empagliflozin once daily in hypertensive Black/African American patients with type 2 diabetes mellitus.
    Curr Med Res Opin 2017 Nov 15:1-15. Epub 2017 Nov 15.
    b Boehringer Ingelheim Pharmaceuticals Inc. , Ridgefield , CT , USA.
    Objective: Black/African American patients have higher prevalence of type 2 diabetes mellitus (T2DM), diabetes-related complications, and hypertension, but they are often underrepresented in clinical trials. The sodium-glucose co-transporter 2 inhibitor, empagliflozin, was associated with significant improvements in glucose control (via hemoglobin [Hb] A1c) and reductions in blood pressure (BP; via office and ambulatory BP monitoring) in a primarily white population with T2DM and hypertension. The aim of this ongoing study is to assess the safety and efficacy of empagliflozin in terms of glucose- and BP-lowering in a self-identified black/African American population with T2DM and hypertension. Read More

    Lower risk of dementia with pioglitazone, compared with other second-line treatments, in metformin-based dual therapy: a population-based longitudinal study.
    Diabetologia 2017 Nov 14. Epub 2017 Nov 14.
    Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, 1 University Road, Tainan, 7010, Taiwan.
    Aims/hypothesis: The effect of pioglitazone was compared with that of other second-line glucose-lowering drugs on the risk of dementia among individuals with type 2 diabetes receiving metformin-based dual therapy.

    Methods: A total of 204,323 individuals with type 2 diabetes aged ≥18 years who were stable metformin users and dementia-free before the initiation of second-line glucose-lowering medication were identified in the period 2000-2011 from Taiwan's National Health Insurance Research Database and followed to the end of 2013. Primary analyses included 51,415 individuals aged ≥65 years without dementia events in the first year of second-line glucose-lowering treatment. Read More

    Five-Year Effectiveness of the Multidisciplinary Risk Assessment and Management Program for Primary Care Patients With Type 2 Diabetes Mellitus‎ (RAMP-DM) on DM-Related Complications and Health Service Uses-A Population-Based and Propensity-Matched Cohort Study.
    Diabetes Care 2017 Nov 14. Epub 2017 Nov 14.
    Department of Family Medicine and Primary Care, Ap Lei Chau Clinic, Ap Lei Chau, The University of Hong Kong, Hong Kong, People's Republic of China.
    Objective: To evaluate the 5-year effectiveness of a multidisciplinary Risk Assessment and Management Program for primary care patients with type 2 Diabetes Mellitus (RAMP-DM)‎.

    Research Design And Methods: A 5-year prospective cohort study was conducted with 121,584 Chinese primary care patients with type 2 DM who were recruited between August 2009 and June 2011. Missing data were dealt with multiple imputations. Read More

    Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions.
    Am J Physiol Endocrinol Metab 2017 Nov 14:ajpendo.00211.2017. Epub 2017 Nov 14.
    Osaka Prefecture University.
    A deficient pancreatic β-cell mass increases the risk of type 2 diabetes mellitus. Here, we investigated the effects of testosterone on the development of pancreatic β-cell mass in male rats. The β-cell mass of male rats castrated at 6 weeks of age was reduced to ~30% of that of control rats at 16 weeks of age, and castration caused glucose intolerance. Read More

    A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training.
    Proteomes 2017 Nov 11;5(4). Epub 2017 Nov 11.
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.
    We performed a systematic review and meta-analysis of proteomics literature that reports human skeletal muscle responses in the context of either pathological decline associated with obesity/T2DM and physiological adaptations to exercise training. Literature was collected from PubMed and DOAJ databases following PRISMA guidelines using the search terms 'proteom*', and 'skeletal muscle' combined with either 'obesity, insulin resistance, diabetes, impaired glucose tolerance' or 'exercise, training'. Eleven studies were included in the systematic review, and meta-analysis was performed on a sub-set (four studies) of the reviewed literature that reported the necessary primary data. Read More

    Chorea associated with nonketotic hyperglycemia: A case report with atypical imaging changes.
    Medicine (Baltimore) 2017 Nov;96(45):e8602
    Department of Neurology, Ningbo No.2 Hospital, Ningbo, China.
    Introduction: This is a unique case of nonketotic hyperglycemic (NKH) chorea in 84-year-old Asian woman. The patient had a history of type 2 diabetes mellitus more than 30 years, but had a poor control of blood sugar. She complained of acute onset of bilateral limb involuntary activities, and being easy to fall within a week. Read More

    Outcomes of percutaneous coronary intervention in patients with coronary chronic total occlusions with versus without type 2 diabetes mellitus: A systematic review and meta-analysis.
    Medicine (Baltimore) 2017 Nov;96(45):e8499
    aInstitute of Cardiovascular Diseases, Yichang Central People's Hospital, Yichang, Hubei Province bInstitute of Cardiovascular Diseases, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P. R. China.
    Background: Nowadays, due to advanced techniques and well-trained interventionists in catheter labs, new scientific research has shown percutaneous coronary intervention (PCI) to be a safe treatment procedure in patients with chronic total occlusion (CTO). However, no study has systematically compared PCI outcomes in CTO patients with versus without type 2 diabetes mellitus (T2DM). Therefore, through this meta-analysis we aimed to systematically solve this issue. Read More

    Prognostic value of glucose metabolism for non-ST-segment elevation infarction patients with diabetes mellitus and single concomitant chronic total occlusion following primary percutaneous coronary intervention.
    Medicine (Baltimore) 2017 Nov;96(45):e8362
    aNO 2 Cadre Wards Medicine bDepartment of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.
    Glucose metabolism status may play a predictive role in the severity of the complications among patients with type 2 diabetes mellitus (DM). However, few studies have focused on the prognostic value of glycosylated hemoglobin (HbA1c) and Homeostatic Model Assessment 2 for Insulin Resistance (HOMA2-IR) in patients with DM, non-ST-segment elevation infarction (NSTEMI), and single concomitant chronic total occlusion (CTO) following primary percutaneous coronary intervention (PCI). Short- and long-term prognostic value of HbA1c and HOMA2-IR in patients with DM with NSTEMI and single CTO who received primary percutaneous transluminal coronary intervention (pPCI). Read More

    The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes mellitus.
    Medicine (Baltimore) 2017 Nov;96(45):e8289
    aZhujiang Hospital, Southern Medical University bState Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann-Whitney U test, or χ test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis. Read More

    CML/CD36 accelerates atherosclerotic progression via inhibiting foam cell migration.
    Biomed Pharmacother 2017 Nov 8;97:1020-1031. Epub 2017 Nov 8.
    Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. Electronic address:
    Among the various complications of type 2 diabetes mellitus, atherosclerosis causes the highest disability and morbidity. A multitude of macrophage-derived foam cells are retained in atherosclerotic plaques resulting not only from recruitment of monocytes into lesions but also from a reduced rate of macrophage migration from lesions. Nε-carboxymethyl-Lysine (CML), an advanced glycation end product, is responsible for most complications of diabetes. Read More

    Hepcidin in Iron Homeostasis: Diagnostic and Therapeutic Implications in Type 2 Diabetes Mellitus Patients.
    Acta Haematol 2017 Nov 15;138(4):183-193. Epub 2017 Nov 15.
    Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    The prevalence of type 2 diabetes is increasing in epidemic proportions worldwide. Evidence suggests body iron overload is frequently linked and observed in patients with type 2 diabetes. Body iron metabolism is based on iron conservation and recycling by which only a part of the daily need is replaced by duodenal absorption. Read More

    Non-apnoea sleep disorder increases the risk of subsequent female infertility- a nationwide population-based cohort study.
    Sleep 2017 Nov 9. Epub 2017 Nov 9.
    School of Public Health, National Defense Medical Center, Taipei, Taiwan.
    Study Objectives: Non-apnoea sleep disorder (NASD) increases the risk of hypertension, type 2 diabetes mellitus (DM), chronic kidney disease (CKD), cardiovascular disease and stroke. However, the risk and the time interval of NASD to female infertility has not been thoroughly understood. Our study aimed to determine whether NASD increases subsequent risk of female infertility. Read More

    Determining the optimal screening interval for type 2 diabetes mellitus using a risk prediction model.
    PLoS One 2017 14;12(11):e0187695. Epub 2017 Nov 14.
    Medicine Institute, Cleveland Clinic, Cleveland OH, United States of America.
    Background: Progression to diabetes mellitus (DM) is variable and the screening time interval not well defined. The American Diabetes Association and US Preventive Services Task Force suggest screening every 3 years, but evidence is limited. The objective of the study was to develop a model to predict the probability of developing DM and suggest a risk-based screening interval. Read More

    Gene expression profiling demonstrates WNT/β-catenin pathway genes alteration in Mexican patients with colorectal cancer and diabetes mellitus.
    J BUON 2017 Sep-Oct;22(5):1107-1114
    Doctorate Program in Molecular Biology, Health Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
    Purpose: Several studies have shown a strong association between diabetes mellitus (DM) and increased risk of colorectal cancer (CRC). The fundamental mechanisms that support this association are not entirely understood; however, it is believed that hyperinsulinemia and hyperglycemia may be involved. Some proposed mechanisms include upregulation of mitogenic signaling pathways like MAPK, PI3K, mTOR, and WNT, which are involved in cell proliferation, growth, and cancer cell survival. Read More

    The modulatory role of cytokines IL-4 and IL-17 in the functional activity of phagocytes in diabetic pregnant women.
    APMIS 2017 Nov 14. Epub 2017 Nov 14.
    Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil.
    The study investigated the role of cytokines IL-4 and IL-17 in the modulation of the functional activity of mononuclear phagocytes in diabetic pregnant women with hyperglycemia. Sixty pregnant women were assigned to the following groups: nondiabetic (ND), mild gestational hyperglycemia (MGH), gestational diabetes mellitus (GDM), or type 2 diabetes mellitus (DM2). The functional activity of phagocytes from maternal blood, cord blood, and colostrum was assessed by determining their superoxide release, phagocytosis, microbicidal activity, and intracellular Ca(2+) release. Read More

    Factors that may Account for Cardiovascular Risk Reduction with a Dipeptidyl Peptidase-4 Inhibitor, Vildagliptin, in Young Patients with Type 2 Diabetes Mellitus.
    Diabetes Ther 2017 Nov 13. Epub 2017 Nov 13.
    Department of Medicine, University of Padova, Padua, Italy.
    Introduction: In a meta-analysis, we observed a significant 37% relative risk reduction in prospectively adjudicated major adverse cardiac events [MACEs, comprising of non-fatal myocardial infarction, non-fatal stroke, cardiovascular (CV) death] with vildagliptin vs. comparators in younger (< 65 years) patients with type 2 diabetes mellitus (T2DM), while the risk was similar in older patients (≥ 65 years). We carried out an exploratory analysis to identify the patient characteristics and on-treatment effects that may have contributed to the different outcomes in the two age groups. Read More

    The Cost-effectiveness of Dulaglutide 1.5mg versus Exenatide QW for the Treatment of Patients with Type 2 Diabetes Mellitus in France.
    Diabetes Ther 2017 Nov 13. Epub 2017 Nov 13.
    , Helsinki, Finland.
    Introduction: Dulaglutide is a novel onceweekly administered glucagon-like peptide 1 receptor agonist (GLP-1 RA) for the management of type 2 diabetes mellitus (T2DM). The objective of this analysis was to estimate the cost-effectiveness of dulaglutide 1.5 mg versus exenatide QW for the management of T2DM in France. Read More

    Intravenous Ferric Carboxymaltose in Patients with Type 2 Diabetes Mellitus and Iron Deficiency: CLEVER Trial Study Design and Protocol.
    Diabetes Ther 2017 Nov 13. Epub 2017 Nov 13.
    Medical Clinic and Policlinic III at the University Hospital Dresden, Dresden, Germany.
    Introduction: HbA1c is the gold standard for glycemic control in pre-diabetes and diabetes. However, its validity has been questioned, especially in the presence of imbalanced iron homeostasis. The CLEVER trial aims to evaluate the relationship between iron deficiency and HbA1c (a biomarker for the diagnosis and therapeutic monitoring of type 2 diabetes) in a randomized, placebo-controlled, multicenter clinical trial. Read More

    Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients.
    Sci Rep 2017 Nov 13;7(1):15416. Epub 2017 Nov 13.
    Departments of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
    Xanthine oxidoreductase activity (XOR-a) plays an important role as a pivotal source of reactive oxygen species. In the present study, we investigated factors associated with plasma XOR-a in 163 hemodialysis patients (age 67.3 ± 10. Read More

    Analysis of the Relationship between Helicobacter pylori Infection and Diabetic Gastroparesis.
    Chin Med J (Engl) 2017 Nov;130(22):2680-2685
    Department of Clinical Medicine, Queen Mary School of Nanchang University, Nanchang, Jiangxi 330031, China.
    Background: Whether Helicobacter pylori infection is associated with diabetic gastroparesis (DGP) is unclear. This study aimed to investigate the potential correlation between H. pylori infection and DGP. Read More

    Canagliflozin for Primary and Secondary Prevention of Cardiovascular Events: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study).
    Circulation 2017 Nov 13. Epub 2017 Nov 13.
    Oxford Centre for Diabetes, Endocrinology and Metabolism and Harris Manchester College, University of Oxford, UK.
    BACKGROUND : Canagliflozin is a sodium glucose cotransporter 2 inhibitor that significantly reduces the composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes mellitus and elevated cardiovascular risk. The comparative effects among participants with and without a history of cardiovascular disease (secondary versus primary prevention) were prespecified for evaluation. METHODS : The CANVAS Program (Canagliflozin Cardiovascular Assessment Study) randomly assigned 10 142 participants with type 2 diabetes mellitus to canagliflozin or placebo. Read More

    Cardiovascular Outcomes and Safety of Empagliflozin in Patients With Type 2 Diabetes Mellitus and Peripheral Artery Disease: A Subanalysis of EMPA-REG OUTCOME.
    Circulation 2017 Nov 13. Epub 2017 Nov 13.
    Lunenfeld- Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Endocrinology, University of Toronto, Ontario, Canada.
    Peripheral artery disease (PAD) is one of the most common cardiovascular complications in patients with type 2 diabetes mellitus (T2DM)(1) and is a predictor of cardiovascular death.(2) Interventions that reduce cardiovascular complications in this patient population are urgently required. In the EMPA-REG OUTCOME trial, the sodium glucose cotransporter 2 inhibitor empagliflozin reduced the risk of cardiovascular death by 38% (hazard ratio [HR], 0. Read More

    Clinical and Histologic Characterization of Nonalcoholic Steatohepatitis in African American Patients.
    Diabetes Care 2017 Nov 13. Epub 2017 Nov 13.
    Division of Endocrinology, Diabetes & Metabolism, University of Florida, Gainesville, FL
    Objective: There has been a widespread misconception among physicians that African Americans are protected from developing nonalcoholic steatohepatitis (NASH). However, a formal histologic and metabolic comparison against well-matched Caucasians has never been performed.

    Research Design And Methods: Sixty-seven African American patients were matched 2:1 to Caucasians (n = 134) for age, sex, BMI, hemoglobin A1c, and prevalence of type 2 diabetes mellitus (T2DM). Read More

    Levels of adhesion molecules in peripheral blood correlat with stages of diabetic retinopathy and may serve as bio markers for microvascular complications.
    Cytokine 2017 Nov 10. Epub 2017 Nov 10.
    Department of Ophthalmology, Baruch Padeh Poria Medical Center, Faculty of Medicine in the Galilee Bar Ilan University, Galilee 15208, Israel.
    Background: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy.

    Methods: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus. Read More

    Relation of Muscle Indices with Metabolic Parameters and C-Peptide in Type 2 Diabetes Mellitus.
    J Coll Physicians Surg Pak 2017 Nov;27(11):673-677
    Department of Family Medicine, Istanbul Medeniyet University Medical School, Istanbul, Turkey.
    Objective: To assess the relation between bioimpedance measurements and metabolic parameters and C-peptide in patient with type 2 diabetes mellitus (DM).

    Study Design: Cross-sectional study.

    Place And Duration Of Study: Kartal Dr Lutfi Kirdar Training and Research Hospital, Pendik Kaynarca Diabetes Center, Exercise and Metabolism Unit, between January and March 2015. Read More

    Exploring Factors Associated with Depression and Anxiety among Hospitalized Patients with Type 2 Diabetes Mellitus.
    Med Princ Pract 2017 Nov 3. Epub 2017 Nov 3.
    Objectives: The aims of the current study were to determine the prevalence and severity of anxiety and depression, and to explore associated factors among hospitalized patients with type 2 diabetes mellitus.

    Subjects And Methods: All patients with type 2 diabetes (160 patients) who were admitted to the Internal Medicine Wards, King Abdulaziz Medical City, Riyadh, Saudi Arabia, during the study period were asked to participate and 158 patients agreed to do so. A self-administered questionnaire consisting of two parts was used. Read More

    Non-Diabetic Kidney Disease in Type 2 Diabetic Patients: Prevalence, Clinical Predictors and Outcomes.
    Kidney Blood Press Res 2017 Nov 1;42(5):886-893. Epub 2017 Nov 1.
    Ankara University School of Medicine, Department of Nephrology, Ankara, Turkey.
    Background/aims: Diabetic kidney disease (DKD) is one of the most frequent microvascular complications of diabetes and is the leading cause of end-stage kidney disease worldwide. In patients with diabetes, non-diabetic kidney disease (NDKD) can also occur. NDKD can be either alone or superimposed with the DKD. Read More

    [Relationship between quality of life, physical activity, nutrition, glycemic control and sarcopenia in older adults with type 2 diabetes mellitus].
    Nutr Hosp 2017 Oct 24;34(5):1198-1204. Epub 2017 Oct 24.
    Instituto de Nutrición y Tecnología de los Alimentos. Centro de Investigación Biomédica. Universidad de Granada..
    Introduction: The term sarcopenia is defined as age-related loss of skeletal muscle mass and function, with a consequent impact on quality of life. However, there is a lack of studies examining the prevalence of sarcopenia in patients with type 2 diabetes mellitus (DM).

    Objectives: To analyze the prevalence of sarcopenia in patients over 65 years with type 2 DM and the influence of physical activity, diet, glycemic control, sex, age, and quality of life. Read More

    Role of microRNAs (miRNAs) in pathophysiology of diabetes mellitus.
    Panminerva Med 2017 Nov 10. Epub 2017 Nov 10.
    Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sidney, Australia.
    Diabetes Mellitus is becoming the critical problem among the entire world and it is difficult to understand the molecular mechanism representing the concept of diabetic pathology. Recently the knowledge of the involvement of genetics in type 2 diabetes mellitus (T2DM) susceptibility has sketched a great concentration towards the transcriptional activity of ß cells within the pancreas. This disease becomes the leading cause of death so it is necessary to study the molecular pathogenesis, phenotypes, and characteristics to design the therapeutic parameters. Read More

    Treatment Gaps Found in the Management of Type 2 Diabetes at a Community Health Centre in Johannesburg, South Africa.
    J Diabetes Res 2017 10;2017:9536025. Epub 2017 Oct 10.
    Carbohydrate and Lipid Metabolism Research Unit, Division of Endocrinology and Metabolism, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
    Aims: The management of cardiometabolic goals or "ABCs" (HbA1c, blood pressure (BP), and cholesterol) ultimately determines the morbidity and mortality outcomes in patients with type 2 diabetes mellitus (T2DM). We sought to determine if patients with T2DM attending an urbanized public sector community health centre (CHC) were having their ABCs measured, were treated with appropriate cardioprotective agents and finally, were achieving guideline-based targets.

    Methods And Results: A cross-sectional record review of 519 patients was conducted between May and August 2015. Read More

    ADDRESSING HYPERTENSION IN THE PATIENT WITH TYPE 2 DIABETES MELLITUS: PATHOGENESIS, GOALS, AND THERAPEUTIC APPROACH.
    Eur Med J Diabetes 2017 Oct;5(1):84-92
    Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
    Hypertension is considered a powerful cardiovascular risk factor and is present in up to two-thirds of patients who suffer from diabetes. In the background of an established epidemiological association between lower blood pressure (BP) and improvement in long-term clinical outcomes, several large landmark trials and analyses have attempted to examine the possible benefit of tighter BP control in patients with Type 2 diabetes mellitus. Although aggressive BP targets in patients with diabetes have been advocated for a long time, currently accepted evidence from these studies has led to a general recommendation of systolic BP <140 mmHg and diastolic BP <90 mmHg. Read More

    Deactivation of the NLRP3 inflammasome in infiltrating macrophages by duodenal-jejunal bypass surgery mediates improvement of beta cell function in type 2 diabetes.
    Metabolism 2017 Nov 9. Epub 2017 Nov 9.
    Department of General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, P.R. China. Electronic address:
    Objective: Bariatric surgery could improve pancreatic beta cell function, thereby leading to the remission of the type 2 diabetes mellitus (T2DM). However, the specific mechanism underlying this phenomenon is yet to be revealed. The aim of this study is to test the hypothesis that Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome in infiltrating macrophages plays an important role in the modulation of beta cell function after duodenal-jejunal bypass (DJB) surgery. Read More

    Health literacy in type 2 diabetes patients: a systematic review of systematic reviews.
    Acta Diabetol 2017 Nov 11. Epub 2017 Nov 11.
    Department of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.
    Aim To summarize, critically review, and interpret the evidence related to the systematic reviews on health literacy (HL) amongst type 2 diabetes mellitus (T2DM). Methods The methodology for this study consisted of a systematic review of systematic reviews, using the PRISMA statement and flowchart to select studies, and searching on PubMed, CINAHL, Scopus, and Cochrane. The search covered the period between January 2006 and June 2016. Read More

    Psoriasis and the Risk of Diabetes: A Prospective Population-Based Cohort Study.
    J Am Acad Dermatol 2017 Nov 8. Epub 2017 Nov 8.
    (1)Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA; (2)Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
    Background: Data evaluating the impact of objectively measured psoriasis severity on type 2 diabetes mellitus (T2DM) risk are lacking.

    Objective: To determine the risk of T2DM in patients with psoriasis compared to adults without psoriasis, stratified by categories of directly assessed body surface area (BSA) affected by psoriasis.

    Methods: A prospective, population-based, cohort study from the UK. Read More

    Detection of SNPs of T2DM susceptibility genes by a ligase detection reaction-fluorescent nanosphere technique.
    Anal Biochem 2017 Nov 9;540-541:38-44. Epub 2017 Nov 9.
    Department of Endocrinology, The Second Hospital of Jilin University, Changchun 130000, China.
    Objective: To establish a high throughput, low cost, and simple nanotechnology-based method for the detection of single nucleotide polymorphism (SNP) loci in type 2 diabetes mellitus (T2DM).

    Methods: Multiplex ligase detection reaction (LDR) amplification was performed using fluorescently labeled magnetic nanosphere-bound upstream LDR probes and downstream probes labeled with a unique fluorescent group for each SNP locus. The amplified LDR products were separated by magnetic nanospheres and then scanned by fluorescence spectroscopy. Read More

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