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    Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease.
    Neuropharmacology 2018 Feb 17. Epub 2018 Feb 17.
    Neurology Department, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; Division of Biomed and Life Sciences, Faculty of Health and Medicine Lancaster University, Lancaster, LA1 4YQ, UK.
    Type 2 diabetes mellitus (T2DM) is a risk factors for developing Parkinson's disease (PD). Insulin desensitization is observed in the brains of PD patients, which may be an underlying mechanism that promotes neurodegeneration. Incretin hormones are growth factors that can re-sensitize insulin signalling. Read More

    MiR-29 family members interact with SPARC to regulate glucose metabolism.
    Biochem Biophys Res Commun 2018 Feb 17. Epub 2018 Feb 17.
    Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Hormone and Endocrinology Key Laboratory of Harbin Medical University, Xuefu Road 246, Harbin, 150080, China. Electronic address:
    MicroRNA (miR)-29 family members have been reported to play important regulatory roles in metabolic disease. We used TargetScan to show that "secreted protein acidic rich in cysteine" (SPARC) is a target of the miR-29s. SPARC is a multifunctional secretory protein involved in a variety of biological activities, and SPARC dysregulation is associated with a wide range of obesity-related disorders, including type 2 diabetes mellitus (T2DM). Read More

    Association of job sectors with type 2 diabetes mellitus, hypercholesterolemia and obesity: a cross-sectional study from the Malaysian Cohort (TMC) project.
    Int Health 2018 Feb 15. Epub 2018 Feb 15.
    UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia.
    Background: The investigation of risk factors of cardiovascular disease (e.g., major endocrine, nutritional and metabolic diseases) across job sectors is useful for targeted public health intervention. Read More

    Correlations of 25(OH)D level with blood lipid, inflammatory factors and vascular endothelial function in diabetic patients.
    Eur Rev Med Pharmacol Sci 2018 Feb;22(3):731-735
    Department of Endocrinology, Anhui Provincial Hospital, Hefei, China.
    Objective: To investigate the correlation between 25-hydroxyvitamin D [25(OH)D] and the lipid profile, inflammatory cytokines, and endothelial function in diabetic patients.

    Patients And Methods: A total of 77 patients with type 2 diabetes mellitus treated in our hospital from January 2015 to March 2017 and 73 healthy volunteers were selected. The 25(OH)D, lipids, inflammatory factors, and endothelial function were compared between the two groups. Read More

    Cardiovascular Disease Risk Factors in Québec Male Firefighters.
    J Occup Environ Med 2018 Feb 15. Epub 2018 Feb 15.
    Département des sciences de l'activité physique (Philippe Gendron, Claude Lajoie, Louis Laurencelle, François Trudeau); Département d'anatomie, Université du Québec à Trois-Rivières (UQTR), 3351, boul. des Forges, Trois-Rivières, Québec, G9A 5H7 (Philippe Gendron).
    Objective: We aimed to document the prevalence of cardiovascular disease (CVD) risk factors and symptoms in Québec firefighters.

    Methods: Seven hundred and seventy-nine (779) male firefighters (age: 41.6 ± 10. Read More

    Georgian Med News 2018 Jan(274):125-130
    Kharkiv National Medical University, Ukraine.
    To improve the effectiveness of diagnosis and prediction of adverse asthma comorbid conditions based on research of clinical manifestations features, functional disorders of the airways and endothelial dysfunction. 79 patients were selected for the study. All the patients were divided into 3 groups: group 1 - patients with asthma (n-22); group II (n-24) - patients with asthma + diabetes mellitus type 2; group III (n-33) - patients with asthma + obesity + arterial hypertension (AH) and control group (n-17) - healthy people. Read More

    Georgian Med News 2018 Jan(274):103-107
    Kharkiv National Medical University; SI «V. Danilevskiy Institute for Endocrine Pathology Problems at AMS of Ukraine, Kharkiv, Ukraine.
    To study the features of secretion of melatonin in the urine in patients with DM type 2 and NAFLD with manifestations of fibrosis and its relationship with some metabolic and immunological parameters, 23 patients with DM type 2 and NAFLD were examined. The degree of fibrosis in patients was diagnosed on the basis of static elastography and the study of indirect fibrosis markers 16 persons (72%) diagnosed with mild fibrosis (F0-F1 on METAVIR), 5 people (18.2%) - with moderate fibrosis (F2-F3 on METAVIR). Read More

    Georgian Med News 2018 Jan(274):92-97
    Kharkov Natonal Medical University, Ukraine.
    Aim of study‒ estimate the influence of the metformin therapy on the sCD40-ligand and sVE-cadherinlevels among patients with acute myocardial infarction and concomitant type 2 diabetes mellitus. The study included44patients with AMI and type 2 diabetes whichweredividedintotwo groupsdependingonthe glucose lowering drugs they have been taken: I group ‒ 21patients who have been taken metformin; II group ‒ 23patients, who have been taken short-acting insulin. Accordingtotheobtainedresults using of metformin as a glucose lowering drug in comparison with patients who have been taken short-acting insulin causes faster decreasing of the sCD40L level (-29,3% and -24,4% accordingly; р<0,05). Read More

    Development of a screening tool using electronic health records for undiagnosed Type 2 diabetes mellitus and impaired fasting glucose detection in the Slovenian population.
    Diabet Med 2018 Feb 20. Epub 2018 Feb 20.
    Faculties of Health Sciences, University of Maribor.
    Aim: To develop and validate a simplified screening test for undiagnosed Type 2 diabetes mellitus and impaired fasting glucose for the Slovenian population (SloRisk) to be used in the general population.

    Methods: Data on 11 391 people were collected from the electronic health records of comprehensive medical examinations in five Slovenian healthcare centres. Fasting plasma glucose as well as information related to the Finnish Diabetes Risk Score questionnaire, FINDRISC, were collected for 2073 people to build predictive models. Read More

    [The efficacy of cocarnit in diabetic neuropathy].
    Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(1):37-42
    Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia.
    Aim: To study the efficacy of the complex therapy, including cocarnit (group B vitamins, triphosadenine and nicotinamide), of diabetic neuropathy.

    Material And Methods: Forty-one patients with diabetes mellitus type 2 and distal symmetric sensorimotor polyneuropathy were examined. Patients were divided into 2 groups. Read More

    Metabolic syndrome among rural Indian adults.
    Clin Nutr ESPEN 2018 Feb 1;23:129-135. Epub 2017 Dec 1.
    Society for Health and Demographic Surveillance, Suri, Birbhum 731101, West Bengal, India. Electronic address:
    Background & Aims: To prevent an increasing level of mortality due to type 2 diabetes mellitus and cardiovascular disease among the rural Indian population, a management strategy of the metabolic syndrome (MetS) should be devised. This study aims to estimate the burden of MetS and its associated risk factors.

    Methods: Data from the Birbhum Population Project covering 9886 individuals (4810 male and 5076 female population) aged ≥18 years were used. Read More

    Serum Metabolomics Study of Gliclazide Modified-release Treated Type 2 Diabetes Mellitus Patients Using a Gas Chromatography-Mass Spectrometry Method.
    J Proteome Res 2018 Feb 20. Epub 2018 Feb 20.
    Sulfonylureas are one of the commonly used drugs in type 2 diabetes mellitus (T2DM), but with considerable incidence of monotherapy failure. However, the mechanism of patients' drug response is unclear and suitability evaluation biomarkers are in urgent need for precision medicine. In this study, a pseudotargeted gas chromatography-mass spectrometry method was employed to investigate the serum metabolic profiling of 66 significant responders and 24 non-significant responders at baseline and 16-week after gliclazide modified-release (MR) monotherapy. Read More

    Clinical Benefit of Basal Insulin Analogue Treatment in Persons with Type 2 Diabetes Inadequately Controlled on Prior Insulin Therapy: A Prospective, Noninterventional, Multicenter Study.
    Diabetes Ther 2018 Feb 19. Epub 2018 Feb 19.
    Clinic for Endocrinology, Faculty of Medicine, University of Nis, Nis, Serbia.
    Introduction: Basal insulin analogues offer persons with type 2 diabetes mellitus (T2DM) adequate glycemic control combined with a favorable safety profile. BASAL-BALI-a prospective, noninterventional, multicenter disease registry-assessed the effectiveness and safety of basal insulin analogues in adult Serbians with T2DM previously inadequately controlled on other insulin types.

    Methods: The primary objective was to assess the reduction in glycated hemoglobin (HbA) from basal insulin analogue initiation to the end of a 6-month observation period. Read More

    Analysis of Postprandial Glycemia in Relation to Metabolic Compensation and Other Observed Parameters of Outpatients with Type 2 Diabetes Mellitus in the Czech Republic.
    Diabetes Ther 2018 Feb 19. Epub 2018 Feb 19.
    Department of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
    Introduction: The goal of the study was to determine the level of metabolic compensation expressed by glycosylated hemoglobin, fasting plasma glucose, and postprandial glucose as determined after a standardized breakfast; further, to evaluate interrelationships between the studied parameters and postprandial glucose levels.

    Methods: The study included 1055 patients with type 2 diabetes mellitus. Their fasting plasma glucose and postprandial glucose were measured before and after a standardized breakfast. Read More

    Assessing the risk of type 2 diabetes mellitus among children and adolescents with psychiatric disorders treated with atypical antipsychotics: a population-based nested case-control study.
    Eur Child Adolesc Psychiatry 2018 Feb 19. Epub 2018 Feb 19.
    College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Incheon, 21983, Republic of Korea.
    To examine the associations between atypical antipsychotic (AAP) exposure and the development of type 2 diabetes mellitus (T2DM) in Korean pediatric patients with psychiatric disorders, we conducted a nested case-control study using the claims data of the National Health Insurance system of Korea between 2010 and 2014. A cohort of patients with psychiatric disorders was identified, and enrollment was taken as the date of the first psychiatric diagnosis. Cases involved patients with a diagnosis of T2DM or prescriptions for glucose lowering drugs after enrollment, and the identification of T2DM was defined as the index date. Read More

    Relative Handgrip Strength Is Inversely Associated with Metabolic Profile and Metabolic Disease in the General Population in China.
    Front Physiol 2018 5;9:59. Epub 2018 Feb 5.
    Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China.
    Absolute handgrip strength has been correlated with metabolic profile and metabolic disease. Whether relative handgrip strength is also associated with metabolic disease has not been assessed. This study aimed at assessing the association of relative handgrip strength with metabolic profile and metabolic disease in the general population in China. Read More

    Erythrocyte Glucose-6-Phosphate Dehydrogenase Level in Type 2 Diabetes Male.
    Mymensingh Med J 2018 Jan;27(1):103-107
    Dr Afruza Khanam, Assistant Professor, Department of Physiology, Marks Medical College, Dhaka, Bangladesh; E-mail:
    The patient with diabetes mellitus (DM) and its complication is increasing in our country and all over the world. There is also significant increase in the prevalence of erythrocyte glucose-6-phosphate dehydrogenase (eG6PD) deficiency in the men with longer duration of diabetes mellitus. To assess the eG6PD in type 2 diabetes male subjects to observe their enzyme status. Read More

    Effect of Sleep-Disordered Breathing on Albuminuria in 273 Patients With Type 2 Diabetes.
    J Clin Sleep Med 2018 Feb 13. Epub 2018 Feb 13.
    Study Objectives: Sleep-disordered breathing (SDB) can induce hyperglycemia, hypertension, and oxidative stress, conditions that are known to cause kidney damage. Therefore, SDB may exacerbate albuminuria, which is an established marker of early-stage kidney damage in patients with type 2 diabetes mellitus (T2DM). The association between SDB and albuminuria in patients with T2DM was investigated in this study. Read More

    Genomic screening for monogenic forms of diabetes.
    BMC Med 2018 Feb 20;16(1):25. Epub 2018 Feb 20.
    Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
    Adult-onset, or type II diabetes mellitus (T2DM) has a complex genetic architecture, from hundreds of genes with low penetrance, common susceptibility variants (e.g., TCF7L2), to a set of more than ten genes that, when mutated, can cause a single-gene or Mendelian form of T2DM (e. Read More

    Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial.
    Drug Res (Stuttg) 2018 Feb 19. Epub 2018 Feb 19.
    Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    Introduction: Curcuminoids have been shown to reduce glycemia and related complications in diabetes. In the present study, we evaluated the impact of curcuminoids plus piperine administration on glycemic, hepatic and inflammatory biomarkers in type 2 diabetes (T2D) patients.

    Methods: T2D patients aged 18-65 years were enrolled in a randomized double-blind placebo-controlled trial and randomly allocated to standard-of-care treatment and dietary advises plus either curcuminoids (daily dose of 500 mg/day co-administered with piperine 5 mg/day) or placebo for a period of 3 months. Read More

    Alcohol and CV Health: Jekyll and Hyde J-Curves.
    Prog Cardiovasc Dis 2018 Feb 16. Epub 2018 Feb 16.
    Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, United States.
    A routine of light or moderate alcohol consumption (≤1 drink/day for women and 1 to 2 drinks/day for men) were associated with a lower risk for all-cause mortality, coronary artery disease (CAD), type 2 diabetes mellitus (T2D), heart failure (HF), and stroke. Conversely, heavy drinking, (>4 drinks/day) is associated with an increased risk for death and cardiovascular (CV) disease (CVD). Excessive alcohol intake trails behind only smoking and obesity among the 3 leading causes of premature deaths in the United States (US). Read More

    Sulfenamide and sulfonamide derivatives of metformin can exert anti-coagulant and pro-fibrinolytic properties.
    Chem Biol Interact 2018 Feb 16. Epub 2018 Feb 16.
    Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, ul. Muszyńskiego1, 90-151 Lodz, Poland.
    Type 2 diabetes mellitus (T2DM) is characterised not only by hyperglycaemia and insulin resistance but also an impaired balance between the processes of coagulation and fibrinolysis. The aim of this study was to examine the effects of metformin, a widely-used oral anti-diabetic drug, phenformin and eight sulfenamide and sulfonamide derivatives of metformin on several haemostasis parameters. Thrombin Time (TT) tests were performed according to the available commercial method. Read More

    Exploring Self-Management on Glycemic Control Using a Modified Information-Motivation-Behavioral Skills Model in Type 2 Diabetes Mellitus Patients in Shanghai, China: a Cross-Sectional Study.
    J Diabetes 2018 Feb 19. Epub 2018 Feb 19.
    School of Public Health, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China.
    Background: The utility and maturity of the original Information-Motivation-Behavioral Skills (IMB) model have been verified in Type 2 Diabetes Mellitus (T2DM) patients. But little research has clarified whether the model has effect on glycemic control. The main purpose of this study is to modify the IMB model to explore self-management on glycemic control in T2DM patients in Shanghai, China. Read More

    The role of type 2 diabetes mellitus on hypertensive-related aortic stiffness.
    Echocardiography 2018 Feb 19. Epub 2018 Feb 19.
    Cardiology Unit, University and ASST Spedali Civili, Brescia, Italy.
    Background: Hypertension is strongly related to arterial stiffness in a cause-effect fashion. Diabetes mellitus is also thought to determine vascular damage, mostly by means of advanced glycosylation end-products (AGEs). Aim of our study was to study the role of type 2 diabetes mellitus (T2DM) as regard ascending aortic elastic properties in hypertensive patients. Read More

    Prevalence and Social Determinants of Type 2 Diabetes in a Coastal Area of Kerala, India.
    J Endocrinol Diabetes 2017 15;4(3). Epub 2017 Sep 15.
    Professor, Chair of Non-Communicable Disease Control &Director of the Centre for Health Equity, Melbourne School of Population and Global Health, University of Melbourne, Australia.
    Introduction: Varying prevalence rates of type 2 diabetes have been observed in different parts of the southern state of Kerala, India which is in an advanced stage of epidemiologic transition. Social patterning is evident in diabetes and therefore it was decided to undertake a study on estimating the prevalence of diabetes and associated social determinants.

    Methodology: The adopted local self administration unit of the Medical College which is also the field practice area with a population of 25,096 was taken for the study. Read More

    Metformin and aspirin treatment could lead to an improved survival rate for Type 2 diabetic patients with stage II and III colorectal adenocarcinoma relative to non-diabetic patients.
    Mol Clin Oncol 2018 Mar 11;8(3):504-512. Epub 2018 Jan 11.
    Department of Medical Sciences, University of Trieste, Cattinara Hospital, I-34149 Trieste, Italy.
    Metformin, the drug of choice in the treatment of type 2 diabetes mellitus (DM2), in addition to aspirin (ASA), the drug prescribed for cardioprotection of diabetic and non-diabetic patients, have an inhibitory effect on cancer cell survival. The present population-based study conducted in the province of Trieste (Italy), aimed to investigate the prevalence of DM2 in patients with colorectal adenocarcinoma (CRC) and survival for CRC in diabetic and nondiabetic patients. All permanent residents diagnosed with a CRC between 2004 and 2007 were ascertained through the regional health information system. Read More

    Correlation of blood glucose, serum chemerin and insulin resistance with NAFLD in patients with type 2 diabetes mellitus.
    Exp Ther Med 2018 Mar 16;15(3):2936-2940. Epub 2018 Jan 16.
    Department of Internal Medicine, Jining Municipal Government Hospital, Jining, Shandong 272100, P.R. China.
    Non-alcoholic fatty liver disease (NAFLD) is a form of clinical syndrome characterized by the fatty degeneration in liver histology and should be further investigated. The aim of the study was to investigate the effects of blood glucose, serum chemerin and insulin resistance on non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus to provide a basis for the prevention and treatment thereof. In total, 300 patients with type 2 diabetes mellitus treated and admitted into the Endocrinology Department of our hospital from June 2015 to June 2017 were enrolled and divided into the simple type 2 diabetes mellitus (group A) and concurrent NAFLD (group B) groups. Read More

    Relationship between fat mass and obesity-associated gene expression and type 2 diabetes mellitus severity.
    Exp Ther Med 2018 Mar 15;15(3):2917-2921. Epub 2018 Jan 15.
    Neurological Intensive Care Unit, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
    This study sought to investigate any correlation between fat mass and obesity-associated gene (FTO) expression and the severity of type 2 diabetes mellitus (T2DM). In total 110 patients newly diagnosed with T2DM in the outpatient department of Yantai Yuhuangding Hospital between September 2016 and March 2017 were selected as study subjects and were divided into severe (58 cases) and mild groups (52 cases) according to T2DM severity. Patients in the severe group were followed up for 12 weeks. Read More

    Drug-drug Interaction-related Uncontrolled Glycemia.
    J Pharm Bioallied Sci 2017 Oct-Dec;9(4):221-228
    Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pehang, Malaysia.
    Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited.

    Aims: The aim of this study is to identify the prevalence, mechanism, severity, with Type 2 diabetes.

    Settings And Design: A cross-sectional study was conducted in Penang General Hospital. Read More

    Elevated tissue sodium deposition in patients with type 2 diabetes on hemodialysis detected byNa magnetic resonance imaging.
    Kidney Int 2018 Feb 15. Epub 2018 Feb 15.
    Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
    Long-term elevated blood sugar levels result in tissue matrix compositional changes in patients with diabetes mellitus type 2 (T2DM). We hypothesized that hemodialysis patients with T2DM might accumulate more tissue sodium than control hemodialysis patients. To test this,Na magnetic resonance imaging (Na MRI) was used to estimate sodium in skin and muscle tissue in hemodialysis patients with or without T2DM. Read More

    A Randomized Trial of Weight Change in a National Home Visiting Program.
    Am J Prev Med 2018 Mar;54(3):341-351
    Prevention Research Center in St. Louis, Brown School, Washington University in St. Louis, St. Louis, Missouri.
    Introduction: Clinical trials have demonstrated significant impact in reducing weight and incidence of type 2 diabetes mellitus. However, the intensity of these trials limits their scalability to real world settings. The purpose of this study was to embed a lifestyle intervention for overweight and obese mothers within the routine practice of a parent education, home visiting organization. Read More

    Evaluation of fractalkine (FKN) and secreted frizzled-related protein 4 (SFRP-4) serum levels in patients with prediabetes and type 2 diabetes.
    Bratisl Lek Listy 2018 ;119(2):112-115
    Objective: The objective of this study is to compare serum levels of FKN and SFRP-4 in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM).

    Methods: A total of 152 patients presented to the endocrinology outpatient clinic of our hospital were included in the study. Eighty-two patients with a history of T2DM were assigned to the T2DM group. Read More

    The risk of type 2 diabetes mellitus according to the categories of body mass index: the Korean Genome and Epidemiology Study (KoGES).
    Acta Diabetol 2018 Feb 17. Epub 2018 Feb 17.
    Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Aims: Obesity is an established risk factor for type 2 diabetes mellitus (T2DM). However, there is limited information on the pattern of relationship between the risk for T2DM and body mass index (BMI) categories including underweight and overweight. Thus, this study was to evaluate the risk of T2DM according to BMI categories defined by Asian-specific cutoff of BMI. Read More

    Serum cystatin C level is associated with carotid arterial wall elasticity in subjects with type 2 diabetes mellitus: a potential marker of early-stage atherosclerosis.
    Diabetes Res Clin Pract 2018 Feb 14. Epub 2018 Feb 14.
    Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:
    Aims: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. Read More

    Glucagon-like peptide-1 contributes to increases ABCA1 expression by downregulating miR-758 to regulate cholesterol homeostasis.
    Biochem Biophys Res Commun 2018 Feb 14. Epub 2018 Feb 14.
    Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. Electronic address:
    Abnormal regulation of lipid metabolism is associated with type 2 diabetes mellitus (T2DM). GLP-1 as a new treatment for T2DM, has unique effects in modulating cholesterol homeostasis. However, the mechanism of this effect is largely missing. Read More

    Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats.
    Endocr Regul 2018 Jan;52(1):6-16
    3Department of Physiology, Benjamen S. Carson (Snr) School of Medicine, Babcock University, Babcock, Nigeria.
    Objective: We investigated the effects of magnesium supplementation on glucose tolerance, insulin sensitivity, oxidative stress as well as the concentration of insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide induced type-2 diabetic (T2D) rats.

    Methods: Rats were divided into four groups designated as: 1) control (CTR); 2) diabetic untreated (DU); 3) diabetic treated with 1 mg of Mg/kg diet (Mg1-D); and 4) diabetic treated with 2 mg of Mg/kg diet (Mg2-D). T2D was induced with a single intraperitoneal (i. Read More

    The Effect of Physical Activity Interventions on Glycosylated Haemoglobin (HbA) in Non-diabetic Populations: A Systematic Review and Meta-analysis.
    Sports Med 2018 Feb 16. Epub 2018 Feb 16.
    Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain.
    Background: Physical activity is widely perceived to be beneficial for preventing type 2 diabetes mellitus and for controlling glycaemic levels in patients with type 2 diabetes, but evidence supporting a positive effect in the control of glycaemic levels in healthy people is rather weak. The aim of this review was to estimate the effect of physical activity on glycaemic control measured by glycosylated haemoglobin (HbA) levels in non-diabetic populations, and to determine which type of physical activity has a greater influence on glycaemic control.

    Methods: We systematically searched the MEDLINE, EMBASE, Cochrane Library and Web of Science databases, from inception to May 2017, for experimental studies addressing the effect of physical activity on glycaemic control measured by HbAlevels in non-diabetic populations. Read More

    Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy.
    Acta Diabetol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Er Road, Yuexiu District, Guangzhou, Guangdong, China.
    Aims: To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA).

    Methods: A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Read More

    The effect of n-3 PUFAs on circulating adiponectin and leptin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.
    Acta Diabetol 2018 Feb 16. Epub 2018 Feb 16.
    Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
    Aim: N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines. Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes, we conducted a systematic review and meta-analysis study of randomized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes.

    Methods: The electronic databases, without regard to language restrictions including PubMed/Medline, Google Scholar, SCOPUS and ISI Web of Science until August 2017, were used to identify randomized controlled trials that assessed the effect of n-3 PUFAs on serum leptin and adiponectin concentrations in type 2 diabetes. Read More

    Serum apolipoprotein A-1 concentrations and the prevalence of cardiovascular autonomic neuropathy in individuals with type 2 diabetes.
    J Diabetes Complications 2018 Jan 31. Epub 2018 Jan 31.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju 501-757, Republic of Korea. Electronic address:
    Objective: To evaluate the relationship between levels of serum apolipoproteins and the prevalence of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes.

    Methods: In total, 3199 individuals with type 2 diabetes were investigated in a cross-sectional study. The diagnosis of CAN was made based on the results of a cardiovascular reflex test. Read More

    Impact of the off-clamp endoscopic robot-assisted simple enucleation (ERASE) of clinical T1 renal tumors on the postoperative renal function: Results from a matched-pair comparison.
    Eur J Surg Oncol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Urology, University of Florence, Careggi Hospital, Florence, Italy. Electronic address:
    Purpose: To evaluate the surgical and functional outcomes of a matched-paired series of on-clamp vs off-clamp endoscopic robot-assisted simple enucleation (ERASE) and standardized renorraphy in a tertiary referral institution, to search for predictors of functional drop after surgery and to investigate the influence of off-clamp technique in patients presenting these characteristics.

    Materials And Methods: A matched-pair comparison of 120 on-clamp vs 120 off-clamp over 491 patients treated with ERASE was performed. Perioperative and functional outcomes were compared between groups. Read More

    The risks of sarcopenia, falls and fractures in patients with type 2 diabetes mellitus.
    Maturitas 2018 Mar 15;109:70-77. Epub 2017 Dec 15.
    Maastricht University, CAPHRI Research School, Department of Family Medicine, Maastricht University, Maastricht, The Netherlands. Electronic address:
    Fracture risk in patients with type 2 diabetes mellitus (T2DM) is increased, and the mechanism is multifactorial. Recent research on T2DM-induced bone fragility shows that bone mineral density (BMD) is often normal or even slightly elevated. However, bone turnover may be decreased and bone material and microstructural properties are altered, especially when microvascular complications are present. Read More

    Dietary zinc intake and whole blood zinc concentration in subjects with type 2 diabetes versus healthy subjects: A systematic review, meta-analysis and meta-regression.
    J Trace Elem Med Biol 2018 Feb 7. Epub 2018 Feb 7.
    International Institute of Nutritional Sciences and Food Safety Studies, University of Central Lancashire, Darwin Building, c/o Psychology School Office, Preston, Lancashire PR1 2HE, UK. Electronic address:
    The aim of this systematic review, meta-analysis and meta-regression was to examine the relationship between type 2 diabetes mellitus (T2DM) and concentration of zinc in whole blood, as well as dietary zinc intake. Searches were performed using Ovid MEDLINE, Embase (Ovid) and The Cochrane Library (CENTRAL). Observational studies conducted on diabetic and healthy adults, with data on dietary zinc intake and/or concentration of zinc in whole blood, were selected. Read More

    GIT2-a keystone in ageing and age-related disease.
    Ageing Res Rev 2018 Feb 13. Epub 2018 Feb 13.
    Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Translational Neurobiology Group, Center of Molecular Neurology, VIB, Antwerp, Belgium. Electronic address:
    Since its discovery, G protein-coupled receptor kinase-interacting protein 2, GIT2, and its family member, GIT1, have received considerable interest concerning their potential key roles in regulating multiple inter-connected physiological and pathophysiological processes. GIT2 was first identified as a multifunctional protein that is recruited to G protein-coupled receptors (GPCRs) during the process of receptor internalization. Recent findings have demonstrated that perhaps one of the most important effects of GIT2 in physiology concerns its role in controlling multiple aspects of the complex ageing process. Read More

    Effects of Canagliflozin Versus Glimepiride on Adipokines and Inflammatory Biomarkers in Type 2 Diabetes.
    Metabolism 2018 Feb 13. Epub 2018 Feb 13.
    Janssen Scientific Affairs, LLC, 1125 Trenton-Harbourton Rd, Titusville, NJ 08560, USA. Electronic address:
    Objective: Type 2 diabetes and obesity are pro-inflammatory states associated with increased risk of cardiovascular disease. Canagliflozin, an SGLT2 inhibitor, demonstrated superiority in lowering HbA1c versus glimepiride with less hypoglycemia and greater weight reduction via loss of fat mass in a 52-week trial of type 2 diabetes patients. This post hoc, exploratory analysis assessed the effects of canagliflozin versus glimepiride on select adipokines, inflammatory biomarkers, and chemokines. Read More

    The role of adiponectin and adipolin as anti-inflammatory adipokines in the formation of macrophage foam cells and their association with cardiovascular diseases.
    Clin Biochem 2018 Feb 13. Epub 2018 Feb 13.
    Department of Biochemistry, Institute Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
    Obesity is one of the major public health concerns that is closely associated with obesity-related disorders such as type 2 diabetes mellitus (T2DM), hypertension, and atherosclerosis. Atherosclerosis is a chronic disease characterized by excess cholesterol deposition in the arterial intima and the formation of foam cells. Adipocytokines or adipokines are secreted by the adipose tissue as endocrine glands; adiponectin and adipolin are among these adipokines that are associated with obese and insulin-resistant phenotypes. Read More

    Glucose effectiveness is a critical pathogenic factor leading to the emergence of glucose intolerance and type 2 diabetes mellitus: an ignored hypothesis.
    Diabetes Metab Res Rev 2018 Feb 16. Epub 2018 Feb 16.
    Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Odense, Denmark.
    Background: Although the ability of glucose to mediate its own in vivo metabolism is long documented, the quantitative measurement of whole body glucose-mediated glucose disposal at basal insulin levels, [glucose effectiveness (GE)], followed the introduction of the Minimal Model IVGTT technique.

    Methods: A literature review, combined with our own studies, of the role of GE in glucose metabolism in normal and "at risk" individuals, was undertaken to determine GE's contribution to glucose homeostasis.

    Results: GE accounts for ~45-65% of glucose disposal in man. Read More

    Profile of patients with Fournier's gangrene and their clinical evolution.
    Rev Col Bras Cir 2018 15;45(1):e1430. Epub 2018 Feb 15.
    State University of Western Paraná, Cascavel, PR, Brazil.
    Objective: to analyze the profile of patients with Fournier's gangrene treated in a public tertiary hospital in western Paraná State.

    Methods: we conducted a cross-sectional, retrospective and descriptive study of patients with Fournier's gangrene treated between January 2012 and November 2016.

    Results: there were 40 patients with Fournier's gangrene treated in the period, 29 (72. Read More

    Different Indexes of Glycemic Variability as Identifiers of Patients with Risk of Hypoglycemia in Type 2 Diabetes Mellitus.
    J Diabetes Sci Technol 2018 Feb 1:1932296818758105. Epub 2018 Feb 1.
    2 Hospital Universitario San Ignacio, Bogotá, Colombia.
    Introduction: Recent publications frequently introduce new indexes to measure glycemic variability (GV), quality of glycemic control, or glycemic risk; however, there is a lack of evidence supporting the use of one particular parameter, especially in clinical practice.

    Methods: A cohort of type 2 diabetes mellitus (T2DM) patients in ambulatory care were followed using continuous glucose monitoring sensors (CGM). Mean glucose (MG), standard deviation, coefficient of variation (CV), interquartile range, CONGA1, 2, and 4, MAGE, M value, J index, high blood glucose index, and low blood glucose index (LBGI) were estimated. Read More

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