133,873 results match your criteria Diabetes Mellitus Type 2


[Utilisation of Psychotherapeutic Assistance By Diabetes Patients with a History of Migration].

Psychother Psychosom Med Psychol 2019 Jan 14. Epub 2019 Jan 14.

Klinik für Psychosomatische Medizin und Psychotherapie, LVR Klinikum, Kliniken der Heinrich-Heine Universität Düsseldorf.

According to available studies, migrant patients are more often affected by diabetes mellitus and comorbid psychological complaints than patients without a history of migration. Less is known about whether these patients receive psychotherapeutic assistance for their complaints and which factors may influence the utilisation of psychotherapy in this patient group. We sought to answer these questions by using culture sensitive material which included a screening for depressive symptoms (the Patient Health Questionnaire) and sociodemographic items. Read More

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http://dx.doi.org/10.1055/a-0754-2459DOI Listing
January 2019

An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: the ADRESA study.

Diabetes Res Clin Pract 2019 Jan 11. Epub 2019 Jan 11.

Department of Endocrinology, Diabetes and Clinical Pharmacology Dubrava University Hospital, Zagreb, Croatia; School of Medicine, University of Zagreb, Croatia.

Aims: To compare the effectiveness of different titration algorithms for insulin glargine U100 used in everyday practice to achieve glycaemic targets in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 526 patients (278 in Slovenia, 248 in Croatia) with T2DM (aged ≥18 years) and treated with insulin glargine prior to inclusion were enrolled. Patients self-titrated insulin glargine according to physicians' guidance. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.001DOI Listing
January 2019

HM47118A, a novel insulinotropic GPR119 agonist and potential oral antidiabetic agent.

Diabetes Res Clin Pract 2019 Jan 11. Epub 2019 Jan 11.

College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Seoul 06974, Republic of Korea. Electronic address:

Aims: The G protein-coupled receptor 119 (GPR119), mainly expressed in the pancreas and gastrointestinal tract, increases the intracellular cyclic AMP accumulation, enhances glucose-dependent insulin secretion from pancreatic β cells, and promotes glucagon-like peptide-1 (GLP-1) production by intestinal L cells. We investigated the activities of a novel GPR119 agonist, HM47118A, in vitro and in vivo.

Methods: In vitro HM47118A activities were evaluated in several cell lines. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.011DOI Listing
January 2019

Conducting and Interpreting Results of Network Meta-Analyses in Type 2 Diabetes Mellitus: A Review of Network Meta-Analyses That Include Sodium Glucose Co-transporter 2 Inhibitors.

Diabetes Res Clin Pract 2019 Jan 11. Epub 2019 Jan 11.

Janssen Global Services, LLC, Raritan, NJ, USA. Electronic address:

Aims: Network meta-analyses (NMAs) are valuable ways to generate comparative effectiveness data for therapies available to treat type 2 diabetes mellitus (T2DM). This review assesses NMAs that evaluate sodium glucose co-transporter 2 (SGLT2) inhibitors for treatment of T2DM and discusses potential issues in conducting and interpreting NMAs.

Methods: A systematic literature search was conducted on September 13, 2018 using the search terms "network meta-analysis," "SGLT2," variations of these terms and individual SGLT2 inhibitor names. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.005DOI Listing
January 2019

Formononetin attenuates kidney damage in type 2 diabetic rats.

Life Sci 2019 Jan 11. Epub 2019 Jan 11.

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, V.L.Mehta road, Vile Parle (W), Mumbai 400056, India. Electronic address:

Aim: Diabetic nephropathy is the commonly developed complication of vasculature in type 2 diabetic patients. Chronic hyperglycemia leads to nephropathy in diabetics because of the formation of excessive reactive oxygen species and advanced glycation end products which is reflected in the form of glomerulosclerosis, tubular atrophy and interstitial fibrosis. As per the various reports reduction in SIRT1 expression in kidney tissue is key factor in the development of nephropathy in diabetes because its reduction in tissue is linked with excessive formation of ROS. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.013DOI Listing
January 2019

Prognostic value of visit-to-visit systolic blood pressure variability related to diabetic kidney disease among patients with type 2 diabetes.

J Hypertens 2019 Jan 11. Epub 2019 Jan 11.

Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou.

Background: This study aimed to evaluate the impact of visit-to-visit variability (VVV) of blood pressure on the risk of diabetic nephropathy and whether it provides additional predictive information among patients with type 2 diabetes mellitus (T2DM) in China.

Methods: We included 12 630 T2DM patients during January 2008-December 2012 using a retrospective cohort design. VVV of SBP was assessed as standard deviation, coefficient of variation and variation independent of mean of the blood pressure readings during the measurement period. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002038DOI Listing
January 2019

Letter by Koh Regarding Article, "Canagliflozin and Heart Failure in Type 2 Diabetes Mellitus: Results From the CANVAS Program (Canagliflozin Cardiovascular Assessment Study)".

Authors:
Kwang Kon Koh

Circulation 2019 Jan;139(3):416-417

Department of Cardiovascular Medicine, Heart Center, Gachon University, Gil Medical Center, Incheon, Korea. Gachon Cardiovascular Research Institute, Incheon, Korea.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037209DOI Listing
January 2019

[Relation between sexual dysfunction and metabolic syndrome].

Orv Hetil 2019 Jan;160(3):98-103

Egészségfejlesztési és Népegészségtani Tanszék, Pécsi Tudományegyetem, Egészségtudományi Kar Pécs.

The prevalence of the metabolic syndrome, type 2 diabetes mellitus, cardiovascular diseases, obesity and depression have increased during the recent years. As the sexual dysfunction is also frequent, we aimed to search for the associations between sexual dysfunction and the metabolic syndrome and its components, respectively, by reviewing the literature. The clinical and biochemical components of the metabolic syndrome included cardiovascular disease, type 2 diabetes mellitus, visceral obesity and depression, furthermore, insulin resistance, atherogenic lipid profile, hypogonadism, chronic systemic inflammation and endothelial dysfunction were all demonstrated to affect adversely the sexual function. Read More

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http://dx.doi.org/10.1556/650.2019.31235DOI Listing
January 2019

The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome.

Redox Biol 2018 Dec 26;21:101091. Epub 2018 Dec 26.

Human Nutrition Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Metabolic syndrome (MetS) is a constellation of cardiometabolic risk factors, which together predict increased risk of more serious chronic diseases. We propose that one consequence of dietary overnutrition is increased abundance of Gram-negative bacteria in the gut that cause increased inflammation, impaired gut function, and endotoxemia that further dysregulate the already compromised antioxidant vitamin status in MetS. This discussion is timely because "healthy" individuals are no longer the societal norm and specialized dietary requirements are needed for the growing prevalence of MetS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183094
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http://dx.doi.org/10.1016/j.redox.2018.101091DOI Listing
December 2018
1 Read

HSP22 suppresses diabetes-induced endothelial injury by inhibiting mitochondrial reactive oxygen species formation.

Redox Biol 2019 Jan 3;21:101095. Epub 2019 Jan 3.

Department of Cardiology, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang 330006, Jiangxi, PR China. Electronic address:

The induction of mitochondrial reactive oxygen species (mtROS) by hyperglycemia is a key event responsible for endothelial activation and injury. Heat shock protein 22 (HSP22) is a stress-inducible protein associated with cytoprotection and apoptosis inhibition. However, whether HSP22 prevents hyperglycemia-induced vascular endothelial injury remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183110
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http://dx.doi.org/10.1016/j.redox.2018.101095DOI Listing
January 2019
1 Read

Elevated levels of α-dicarbonyl compounds in the plasma of type II diabetics and their relevance with diabetic nephropathy.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 29;1106-1107:19-25. Epub 2018 Dec 29.

National Engineering Research Center for Miniaturized Detection Systems and College of Life Sciences, Northwest University, 229 North Taibai Road, Xi'an, Shaanxi 710069, China. Electronic address:

The presence of α‑dicarbonyl compounds (α-DCs) in vivo has been associated with the development of complications of diabetes mellitus (DM) and also with other chronic diseases. Therefore, quantitative analysis of α-DCs in body fluids is crucial to understand their roles in the formation of these chronic diseases. We established in this study a practical HPLC-UV method to measure 3‑deoxyglucosone (3-DG), glyoxal (GO), methylglyoxal (MGO), diacetyl (DA), and pentane‑2,3‑dione (PD) in blood plasma using 4‑(2,3‑dimethyl‑6‑quinoxalinyl)‑1,2‑benzenediamine (DQB) as a derivatizing reagent. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183140
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http://dx.doi.org/10.1016/j.jchromb.2018.12.027DOI Listing
December 2018
1 Read

SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes.

Eur J Pharmacol 2019 Jan 10. Epub 2019 Jan 10.

Center for Pharmacy and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, Georgia, USA; Charlie Norwood VA Medical Center, Augusta, Georgia, USA; Vascular Biology Center, Department of Pharmacology and Toxicology, Augusta University, Augusta, Georgia, USA; Department of Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. Electronic address:

The prevalence of type 2 diabetes mellitus (T2D) has risen in the United States and worldwide, with an increase in global prevalence from 4.7% to 8.5% between 1980 and 2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193001
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http://dx.doi.org/10.1016/j.ejphar.2019.01.002DOI Listing
January 2019
2 Reads

Preliminary efficacy and feasibility of referral to exercise specialists, psychologists and provision of a technology-based behavior change support package to promote physical activity in school teachers 'at risk' of, or diagnosed with, type 2 diabetes: The 'SMART Health' Pilot Study Protocol.

Contemp Clin Trials 2019 Jan 10. Epub 2019 Jan 10.

University of Newcastle, Australia, Priority Research Centre for Physical Activity and Nutrition, Level 3 Advanced Technology Centre (ATC316), Callaghan, NSW 2308, Australia. Electronic address:

Introduction: Type 2 diabetes mellitus (T2DM) is a global public health concern. Aerobic physical activity (PA) and resistance training (RT) play significant roles in the prevention and management of T2DM. The aim of this pilot trial is to determine the preliminary efficacy and confirm feasibility of referral to exercise physiologists, psychologists, and provision of a technology-based behavior change support package to promote aerobic PA and RT in school teachers 'at risk' of or diagnosed with T2DM. Read More

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http://dx.doi.org/10.1016/j.cct.2019.01.007DOI Listing
January 2019
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Kaposi's sarcoma associated herpesvirus seropositivity is associated with type 2 diabetes mellitus: A case-control study in Xinjiang, China.

Int J Infect Dis 2019 Jan 9. Epub 2019 Jan 9.

Key Laboratory of Xinjiang Endemic and Ethnic Disease & Department of Biochemistry, School of Medicine, Shihezi University, Shihezi 832000, China. Electronic address:

Objectives: To assess the potential relationship between Kaposi's sarcoma-associated herpesvirus (KSHV) infection and type 2 diabetes mellitus (DM-2) in Xinjiang, China.

Methods: A case-control study of consecutively included DM-2 patients and normal controls was conducted among the Uygur and Han populations in Xinjiang Uygur Autonomous Region, China. Blood samples were collected and KSHV seroprevalence, antibody titers, and viral load were detected. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.003DOI Listing
January 2019
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[Evaluation of the effectiveness of rehabilitation of elderly patients with metabolic syndrome, taking into account the provisions of International classification of functioning, disability and health.]

Adv Gerontol 2018 ;31(5):768-773

G.A.Albrecht Federal Scientific Center of Rehabilitation of the Disabled, 50, Bestuzhevskaya str., St. Petersburg 195067, Russian Federation; e-mail:

The article contains data on rehabilitation measures in elderly patients with metabolic syndrome. Individual-oriented treatment and rehabilitation programs implemented in primary health care allow to reliably reduce the severity and risk of progression of restrictions of life, increase the independence of patients The elderly, having metabolic syndrome, complicated the development of type 2 diabetes mellitus. It is proposed to assess the effectiveness of rehabilitation, taking into account the provisions of the International Classification of functioning, restrictions on life and health and by drawing up an individual geriatric profile. Read More

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January 2018

The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice.

Neurol Res 2019 Jan 13:1-13. Epub 2019 Jan 13.

b Institute of Anatomy , University of Leipzig , Leipzig , Germany.

Introduction: Here, we investigated inflammatory signs of peripheral nerves in leptin-deficient obese ob/ob mice and the modulating effects of the exogenous iron load.

Methods: Ob/ob and ob/+ control mice were fed with high, standard, or low iron diet for four months.

Results: We found intraepidermal nerve fiber degeneration in foot skin and low-grade neuropathic abnormalities including mildly slowed motor and compound sensory nerve conduction velocities and low-grade macrophage and T-cell infiltration without overt neuropathology in sciatic nerves of all ob/ob mice. Read More

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http://dx.doi.org/10.1080/01616412.2018.1564191DOI Listing
January 2019

Sulfonylurea and neuroprotection: The bright side of the moon.

J Adv Pharm Technol Res 2018 Oct-Dec;9(4):120-123

Department of Clinical Pharmacology and Therapeutic, Medical Faculty, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.

Sulfonylurea (SUR) agents are the second and most used oral hypoglycemic drugs after metformin and they still as an imperative tool for most favorable of glucose control. SURs are used mainly in the management of Type 2 diabetes mellitus since; they are effective in the glycemic control and reduction of microvascular complications. First-generation SUR represents 3% of used oral hypoglycemic agents while second and third generations are used in about 25% in patients with Type 2 diabetes mellitus. Read More

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http://dx.doi.org/10.4103/japtr.JAPTR_317_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302683PMC
January 2019

Uropathogens antibiotic resistance patterns among type 2 diabetic patients in Kisii Teaching and Referral Hospital, Kenya.

Pan Afr Med J 2018 23;30:286. Epub 2018 Aug 23.

Department of Medical Laboratory Sciences, Kenyatta University, Nairobi, Kenya.

Introduction: Non-insulin dependent diabetes mellitus is a major risk factor for urinary tract infections. Irrational use of antibiotics has led to the emergency of uropathogens resistant to available antibiotics. The main objective was to determine the bacterial causative agents of urinary tract infections and their antibiotic resistance patterns. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.286.15380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317395PMC
August 2018
2 Reads

Influence of self-efficacy management on adherence to self-care activities and treatment outcome among diabetes mellitus type 2.

Pharm Pract (Granada) 2018 Oct-Dec;16(4):1274. Epub 2018 Dec 25.

Jabir Abu Elizz Diabetes Centre. Khartoum (Sudan).

Background: High level of self-efficacy and adherence to self-care activities have a positive impact on the achievement of glycemic goal among diabetic patients. In Sudan, there is a gap in knowledge related to self-efficacy management and its influence on adherence to self-care activities and overall disease control.

Objective: To identify the influence of management self-efficacy on adherence to self-care activities and treatment outcome among Sudanese patients with type 2 diabetes mellitus. Read More

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http://dx.doi.org/10.18549/PharmPract.2018.04.1274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322981PMC
December 2018

Incipient Albuminuria in Persons with Newly Diagnosed Type 2 Diabetes Mellitus: A 5-Year Retrospective Cohort Study.

Ann Acad Med Singapore 2018 Dec;47(12):502-508

Chronic Disease Epidemiology, Population Health, National Healthcare Group, Singapore.

Introduction: This study aimed to determine the 5-year incidence of albuminuria among Asian persons with newly diagnosed type 2 diabetes mellitus (DM), and to identify the risk factors at diagnosis for progression to albuminuria.

Materials And Methods: A retrospective 5-year closed cohort study was conducted among 1016 persons aged ≥18 years old who were diagnosed with type 2 DM between 1 January 2007 and 31 December 2009 at primary care facilities in Singapore. The cumulative incidence of progression from normoalbuminuria to albuminuria-termed "progression"-was determined. Read More

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December 2018
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Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes.

J Periodontal Res 2019 Jan 11. Epub 2019 Jan 11.

Discipline of Periodontology, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Background And Objective: Subjects with diabetes and periodontitis are at high risk of cardiovascular events, while the subclinical alterations of cardiac function in this cohort remain unclear. This cross-sectional study investigated the association of periodontitis with left ventricle (LV) structural and functional abnormalities in subjects with type 2 diabetes mellitus (T2DM).

Material And Methods: A total of 115 subjects with T2DM were divided into Control group (n = 32) with no or mild periodontitis, and the rest with moderate to severe chronic periodontitis (CP) were further categorized into CP-1 (n = 41) and CP-2 (n = 42) based on disease severity. Read More

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http://doi.wiley.com/10.1111/jre.12634
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http://dx.doi.org/10.1111/jre.12634DOI Listing
January 2019
3 Reads

Rare diagnosis in a patient with diabetes with nephrotic proteinuria.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Nephrology Department, Centro Hospitalar de Lisboa Central, Lisboa, Portugal.

We report a 63-year-old man with well-controlled type 2 diabetes mellitus and hypertension, who presented with new onset nephrotic proteinuria and rapid deterioration in renal function. The atypical clinical presentation prompted us to consider a non-diabetic and non-hypertensive cause and to perform a renal biopsy. A diagnosis of fibrillarglomerulonephritis (FGn) was made based on electronic microscopy. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22383
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http://dx.doi.org/10.1136/bcr-2017-223835DOI Listing
January 2019
1 Read

Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach.

Cardiovasc Diabetol 2019 Jan 11;18(1). Epub 2019 Jan 11.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, People's Republic of China.

Background: Serum haptoglobin (Hp) has been closely associated with cardio-cerebrovascular diseases. We investigated a metabolic profile associated with circulating Hp and carotid arterial functions via a targeted metabolomics approach to provide insight into potential mechanisms.

Methods: A total of 240 participants, including 120 patients with type 2 diabetes mellitus (T2DM) and 120 non-diabetes mellitus (non-DM) subjects were recruited in this study. Read More

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https://cardiab.biomedcentral.com/articles/10.1186/s12933-01
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http://dx.doi.org/10.1186/s12933-019-0808-2DOI Listing
January 2019
1 Read

Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects.

Cardiovasc Diabetol 2019 Jan 11;18(1). Epub 2019 Jan 11.

U.O.C. Clinica Medica e Malattie Vascolari, Department of Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo F. Vito 1, 00168, Rome, Italy.

Background: Sortilin is a 95-kDa protein which has recently been linked to circulating cholesterol concentration and lifetime risk of developing significant atherosclerotic disease. Sortilin is found inside different cell types and circulating in blood. Higher circulating sortilin concentration has been found in patients with coronary atherosclerosis compared to control subjects. Read More

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https://cardiab.biomedcentral.com/articles/10.1186/s12933-01
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http://dx.doi.org/10.1186/s12933-019-0805-5DOI Listing
January 2019
1 Read

Discontinuously supervised aerobic training vs. physical activity promotion in the self-management of type 2 diabetes in older Italian patients: design and methods of the 'TRIPL-A' randomized controlled trial.

BMC Geriatr 2019 Jan 11;19(1):11. Epub 2019 Jan 11.

IRCCS INRCA, Scientific Direction, Via della Montagnola, 81-60127, Ancona, Italy.

Background: Physical activity (PA) has health benefits for people with type 2 diabetes (T2D). Indeed, regular PA is considered an important part of any T2D management plan, yet most patients adopt a sedentary lifestyle. Exercise referral schemes (ERS) have the potential to effectively promote physical activity among T2D patients, and their effectiveness may be enhanced when they are supported by computer-based technologies. Read More

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http://dx.doi.org/10.1186/s12877-018-1022-xDOI Listing
January 2019
1 Read

Vitamin D status is associated with 1,5-anhydro-D-glucitol status in type 2 diabetes mellitus patients.

Appl Physiol Nutr Metab 2019 Jan 11. Epub 2019 Jan 11.

Shanghai Xuhui Central Hospital, Department of Endocrinology, Shanghai, China ;

Purpose: Serum 1,5-anhydro-D-glucitol (1,5-AG) concentrations are short-term hyperglycemia indicators and were used to estimate the effects of serum vitamin D concentrations on glycemic control in type 2 diabetes mellitus (T2DM) patients.

Methods: 1,5-AG and 25-hydroxy vitamin D2 (25-OH-D2) and 25-hydroxy vitamin D3 (25-OH-D3) serum concentrations from 11,026 T2DM patients, hospitalized in the Department of Endocrinology, Shanghai Central Hospital of Xuhui District from January 2012 to June 2015 were retrospectively analyzed.

Results: Correlation analyses revealed correlations between 1,5-AG and 25-OH-D3 (r = 0. Read More

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http://www.nrcresearchpress.com/doi/10.1139/apnm-2018-0719
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http://dx.doi.org/10.1139/apnm-2018-0719DOI Listing
January 2019
1 Read

Acupuncture and related techniques for type 2 diabetes mellitus: A systematic review protocol.

Medicine (Baltimore) 2019 Jan;98(2):e14059

Evidence-based Medicine Research Center, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi.

Background: Type 2 diabetes mellitus (T2DM) is a major global health problem. As a complementary treatment, acupuncture and related techniques are widely used to treat metabolic and endocrine diseases, but their efficacy and safety for T2DM are yet to be established. This systematic review will qualitatively and quantitatively summarize the current randomized controlled trial (RCT) evidence regarding the efficacy and safety of acupuncture and related techniques in patients with T2DM. Read More

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http://dx.doi.org/10.1097/MD.0000000000014059DOI Listing
January 2019
2 Reads

[Antidiabetic role of high density lipoproteins].

Biomed Khim 2018 Nov;64(6):463-471

Institute of Biochemistry, Federal Research Center of Fundamental and Translation Medicine, Novosibirsk, Russia.

Disturbance in lipid metabolism can be both a cause and a consequence of the development of diabetes mellitus (DM). One of the most informative indicator of lipid metabolism is the ratio of atherogenic and antiatherogenic fractions of lipoproteins and their protein components. The review summarizes literature data and own results indicating the important role of high-density lipoprotein (HDL) and their main protein component, apolipoprotein A-I (apoA-I), in the pathogenesis of type 2 DM. Read More

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http://dx.doi.org/10.18097/PBMC20186406463DOI Listing
November 2018
1 Read

Mobile App for Improved Self-Management of Type 2 Diabetes: Multicenter Pragmatic Randomized Controlled Trial.

JMIR Mhealth Uhealth 2019 Jan 10;7(1):e10321. Epub 2019 Jan 10.

Women's College Hospital Institute for Health System Solutions and Virtual Care, Women's College Hospital, Toronto, ON, Canada.

Background: As the increasing prevalence of type 2 diabetes mellitus has put pressure on health systems to appropriately manage these patients, there have been a growing number of mobile apps designed to improve the self-management of diabetes. One such app, BlueStar, has been shown to significantly reduce hemoglobin A (HbA) levels in small studies and is the first app in the United States to receive Food and Drug Administration approval as a mobile prescription therapy. However, the impact of the app across real-world population among different clinical sites and health systems remains unclear. Read More

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https://mhealth.jmir.org/2019/1/e10321/
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http://dx.doi.org/10.2196/10321DOI Listing
January 2019
2 Reads

Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential.

Crit Rev Food Sci Nutr 2019 Jan 11:1-14. Epub 2019 Jan 11.

a College of Life Sciences and Agronomy , Zhoukou Normal University , Zhoukou , China.

Type 2 diabetes mellitus (T2DM) has become one of the most prevalent diseases on earth and several treatments have been developed. However, the current intervention approaches have not been as effective as expected. One promising supplementary strategy is the use of probiotics through direct or indirect approaches. Read More

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https://www.tandfonline.com/doi/full/10.1080/10408398.2018.1
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http://dx.doi.org/10.1080/10408398.2018.1547268DOI Listing
January 2019
1 Read

Association of Serum 25-Hydroxyvitamin D Concentrations With Glucose Profiles in Male Collegiate Football Athletes.

Int J Sport Nutr Exerc Metab 2019 Jan 11:1-23. Epub 2019 Jan 11.

5 Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan.

Low serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with high risk of insulin resistance and type 2 diabetes mellitus (T2DM) in adults. However, it is unknown whether this is the case in American collegiate football and rugby athletes. This study investigated the associations between serum 25(OH)D concentrations and glucose profiles in male collegiate football athletes. Read More

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https://journals.humankinetics.com/doi/10.1123/ijsnem.2018-0
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http://dx.doi.org/10.1123/ijsnem.2018-0225DOI Listing
January 2019
1 Read

Left ventricular metabolic remodeling and accompanied dysfunction in type 2 diabetic patients: A 3D speckle tracking analysis.

Echocardiography 2019 Jan 10. Epub 2019 Jan 10.

Department of Ultrasound, Xinqiao Hospital, The Third Military Medical University, Chongqing, China.

Purposes: The purposes of our study were to determine the risk factors related to metabolic left ventricular remodeling (LVR) in type 2 diabetes mellitus (T2DM) patients and to assess the LV function with different geometry in such population.

Methods: Seventy-eight T2DM patients with normal 2D-LVEF (≥55%) were enrolled and divided into two groups with LV normal geometry (LVN) and with LV remodeling (LVR). The control group was composed of forty age- and sex-matched healthy individuals with LVN. Read More

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http://doi.wiley.com/10.1111/echo.14248
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http://dx.doi.org/10.1111/echo.14248DOI Listing
January 2019
1 Read

The Antidiabetic Potential of Black Mulberry Extract-Enriched Pasta through Inhibition of Enzymes and Glycemic Index.

Plant Foods Hum Nutr 2019 Jan 10. Epub 2019 Jan 10.

Department of Food Science and Technology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.

In the present work, pasta enriched in different formulations by black mulberry extract in order to inhibit enzymes related to starch hydrolyzation. Total phenol content (TPC), antioxidant activity and anthocyanin components of ethanol/water black mulberry extract were investigated. TPC of the black mulberry extract was found 65. Read More

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http://link.springer.com/10.1007/s11130-018-0711-0
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http://dx.doi.org/10.1007/s11130-018-0711-0DOI Listing
January 2019
2 Reads

The effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study.

Diabetologia 2019 Jan 10. Epub 2019 Jan 10.

MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

Aims/hypothesis: Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, is indicated for improving glycaemic control in type 2 diabetes mellitus. Whether its effects on HbA and other variables, including safety outcomes, in clinical trials are obtained in real-world practice needs to be established.

Methods: We used data from the comprehensive national diabetes register, the Scottish Care Information-Diabetes (SCI-Diabetes) collaboration database, available from 2004 to mid-2016. Read More

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http://dx.doi.org/10.1007/s00125-018-4806-9DOI Listing
January 2019

Euglycemic Diabetic Ketoacidosis Due to Sodium-Glucose Cotransporter 2 Inhibitor Use in Two Patients Undergoing Pancreatectomy.

J Pancreat Cancer 2018 15;4(1):95-99. Epub 2018 Nov 15.

Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.

Euglycemic diabetic ketoacidosis (euDKA) is a potential side effect associated with inhibitors of the sodium-glucose cotransporter 2 (SGLT-2). This effect is most often recognized during physiologic stress (i.e. Read More

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https://www.liebertpub.com/doi/10.1089/pancan.2018.0016
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http://dx.doi.org/10.1089/pancan.2018.0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319615PMC
November 2018
1 Read

Thyroid Function in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy: A Single Center Study.

J Thyroid Res 2018 2;2018:9507028. Epub 2018 Dec 2.

Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian 116033, China.

Background: Diabetes mellitus is a common metabolic disease and the prevalence is increasing rapidly. Thyroid disorders including subclinical hypothyroidism (SCH) and low triiodothyronine (T3) syndrome are frequently observed in diabetic patients. We conducted a study to explore thyroid function in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). Read More

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https://www.hindawi.com/journals/jtr/2018/9507028/
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http://dx.doi.org/10.1155/2018/9507028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304540PMC
December 2018
1 Read

Systemic Factors During Metabolic Disease Progression Contribute to the Functional Decline of Adipose Tissue-Derived Mesenchymal Stem Cells in Reproductive Aged Females.

Front Physiol 2018 18;9:1812. Epub 2018 Dec 18.

Division of Endocrinology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

It is known that advanced metabolic disorders such as type 2 diabetes compromise the functional and regenerative capacity of endogenous adipose-tissue resident stem cells (ADSCs). It is, however, still unclear at which stage of disease progression ADSCs become compromised and whether systemic factors contribute to their functional decline. It was therefore hypothesized that inflammatory changes in the systemic microenvironment during distinct stages of disease progression negatively affect the functional capacity of ADSCs. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2018.01812
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http://dx.doi.org/10.3389/fphys.2018.01812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315119PMC
December 2018
2 Reads

Aortic-to-brachial artery stiffness gradient is not blood pressure independent.

J Hum Hypertens 2019 Jan 10. Epub 2019 Jan 10.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

Aortic stiffness predicts cardiovascular mortality but is limited as a risk marker because it is dependent on blood pressure (BP). A potential solution is provided from the ratio of aortic-to-brachial artery stiffness (ab-ratio), which has been shown to be a BP-independent risk marker among patients with renal dysfunction (RD). We sought to determine the BP independence of the ab-ratio in patients with disease, including RD, and healthy populations. Read More

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http://www.nature.com/articles/s41371-018-0154-y
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http://dx.doi.org/10.1038/s41371-018-0154-yDOI Listing
January 2019
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Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population.

Acta Med Indones 2018 Oct;50(4):314-319

Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya - Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia.

Background: diabetic nephropathy (DN) is the leading cause of blood dialysis worldwide and a major etiology of End-Stage Renal Disease cases in Indonesia. Previous studies showed a relevant link between A1166C polymorphism of Angiotensin II Type-1 Receptor (AT1R) gene and glomerular hyper-filtration as a part of pathogenesis of DN. The aim of this study was to elaborate the association between A1166C AT1R polymorphism and susceptibility of individual with type-2 diabetes to DN in Malay Indonesian population. Read More

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October 2018
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Prediction of individual life-years gained without cardiovascular events from lipid, blood pressure, glucose, and aspirin treatment based on data of more than 500 000 patients with Type 2 diabetes mellitus.

Eur Heart J 2019 Jan 9. Epub 2019 Jan 9.

Department of Vascular Medicine, University Medical Center Utrecht, GA Utrecht, the Netherlands.

Aims: Although group-level effectiveness of lipid, blood pressure, glucose, and aspirin treatment for prevention of cardiovascular disease (CVD) has been proven by trials, important differences in absolute effectiveness exist between individuals. We aim to develop and validate a prediction tool for individualizing lifelong CVD prevention in people with Type 2 diabetes mellitus (T2DM) predicting life-years gained without myocardial infarction or stroke.

Methods And Results: We developed and validated the Diabetes Lifetime-perspective prediction (DIAL) model, consisting of two complementary competing risk adjusted Cox proportional hazards functions using data from people with T2DM registered in the Swedish National Diabetes Registry (n = 389 366). Read More

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http://dx.doi.org/10.1093/eurheartj/ehy839DOI Listing
January 2019
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Impact of obesity on longitudinal changes to cardiac structure and function in patients with Type 2 diabetes mellitus.

Eur Heart J Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Division of Cardiology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Room 1929B, Block K, Pokfulam Road, Hong Kong, China.

Aims: Few prospective studies have evaluated the natural progression of left ventricular (LV) remodelling in patients with Type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the impact of obesity on longitudinal cardiac structural and functional changes in patients with T2DM.

Methods And Results: This study comprised of 274 patients with T2DM (mean age, 62. Read More

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https://academic.oup.com/ehjcimaging/advance-article/doi/10.
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http://dx.doi.org/10.1093/ehjci/jey217DOI Listing
January 2019
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Herbal medicine in the treatment of patients with type 2 diabetes mellitus.

Chin Med J (Engl) 2019 Jan;132(1):78-85

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.

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http://Insights.ovid.com/crossref?an=00029330-201901050-0001
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http://dx.doi.org/10.1097/CM9.0000000000000006DOI Listing
January 2019
2 Reads

[Macrophage migration inhibitory factor (MIF) gene -173 G>C polymorphism and its relationship to coronary artery disease and type 2 diabetes].

Turk Kardiyol Dern Ars 2019 Jan;47(1):29-37

Department of Genetics, İstanbul University Aziz Sancar Experimental Medicine Research Institute, İstanbul, Turkey.

Objective: Recent studies indicate that macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine which mediates the inflammatory process during atherosclerosis. The purpose of the study was to investigate an association between MIF gene polymorphism and type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) in the Turkish population.

Methods: A total of 139 unselected Turkish patients with significant CAD (coronary lesion with 50-100% stenosis) and 120 control participants (coronary lesion with <30% stenosis) were genotyped for MIF rs755622 polymorphisms using hybridization probes in a Roche LightCycler 480 Real-Time Polymerase Chain Reaction 480 device. Read More

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http://dx.doi.org/10.5543/tkda.2018.35005DOI Listing
January 2019

Lower BMI is of not more benefit to diabetic complications.

J Diabetes Investig 2019 Jan 9. Epub 2019 Jan 9.

Department of Endocrinology, the First Affiliated Hospital of Fujian Medical University, Diabetes Research Institute of Fujian Province, 20 Cha Zhong Road, Fuzhou, Fujian, 350005, China.

Aim: To investigate the relationship between different body mass index (BMI) levels and vascular complications in type 2 diabetic mellitus (T2DM) patients.

Methods: Data were collected from 3,224 individuals with T2DM (M/F: 1635/1589; age: 61.31±11. Read More

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http://doi.wiley.com/10.1111/jdi.13003
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http://dx.doi.org/10.1111/jdi.13003DOI Listing
January 2019
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Molecular evidence of field cancerization initiated by diabetes in colon cancer patients.

Mol Oncol 2019 Jan 9. Epub 2019 Jan 9.

Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain.

The potential involvement of type 2 diabetes mellitus (T2DM) as a risk factor for colon cancer (CC) has been previously reported. While several clinical studies show a higher incidence of CC and a lower survival rate in diabetics, others report no association. Our own experience indicates that diabetes does not seem to worsen the prognosis once the tumor is present. Read More

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http://doi.wiley.com/10.1002/1878-0261.12438
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http://dx.doi.org/10.1002/1878-0261.12438DOI Listing
January 2019
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Effect of the EndoBarrier Device: a 4-Year Follow-up of a Multicenter Randomized Clinical Trial.

Obes Surg 2019 Jan 9. Epub 2019 Jan 9.

Department of General Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Objective: To evaluate the long-term effect of the duodenal-jejunal bypass liner (DJBL) on weight loss and glycemic control.

Background: Data on the long-term effect of DJBL treatment is still missing.

Methods: From 2010 to 2012, 29 patients were treated with the DJBL at center A and center B, as part of a multicenter randomized controlled trial. Read More

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http://link.springer.com/10.1007/s11695-018-03659-6
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http://dx.doi.org/10.1007/s11695-018-03659-6DOI Listing
January 2019
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Differential associations between diet and prediabetes or diabetes in the KORA FF4 study.

J Nutr Sci 2018 27;7:e34. Epub 2018 Dec 27.

Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Independent Research Unit Clinical Epidemiology, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.

Type 2 diabetes mellitus (T2DM) is a global public health epidemic. Diet and lifestyle changes have been demonstrated as effective measures in managing T2DM and preventing or delaying the progression from prediabetes to diabetes, yet the relationship between diet, prediabetes and diabetes is still not entirely clear. The present study aimed to further elucidate the relationship between diet, diabetes and especially prediabetes. Read More

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https://www.cambridge.org/core/product/identifier/S204867901
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http://dx.doi.org/10.1017/jns.2018.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313408PMC
December 2018
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Effects of Sitagliptin on Pancreatic Beta-Cells in Type 2 Diabetes With Sulfonylurea Treatment: A Prospective Randomized Study.

J Clin Med Res 2019 Jan 3;11(1):15-20. Epub 2018 Dec 3.

Department of Diabetes, Endocrinology and Metabolism, Division of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Background: This prospective randomized, multicenter, open-label, comparative study was performed to analyze the effects of sitagliptin on glycemic control and maintenance of beta-cell function in patients with poorly controlled type 2 diabetes treated with low-dose glimepiride.

Methods: Forty-one patients with type 2 diabetes mellitus treated with low-dose glimepiride (≤ 2 mg/day) were prospectively enrolled in this study (age: 20 - 75 years; hemoglobin A1c (HbA1c): 7.4- 9. Read More

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http://dx.doi.org/10.14740/jocmr3632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306137PMC
January 2019
2 Reads

Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Division of Cardiology, Department of Medicine, the Lillehei Heart Institute, University of Minnesota at Twin Cities, Minneapolis, Minnesota.

In heart failure and type 2 diabetes mellitus (DM), the majority of patients have hypomagnesemia, and magnesium (Mg) supplementation has improved cardiac function and insulin resistance. Recently, we have shown that DM can cause cardiac diastolic dysfunction (DD). Therefore, we hypothesized that Mg supplementation would improve diastolic function in DM. Read More

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https://insight.jci.org/articles/view/123182
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http://dx.doi.org/10.1172/jci.insight.123182DOI Listing
January 2019
7 Reads