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Comput Math Methods Med 2022 18;2022:2851572. Epub 2022 Jun 18.

Department of Endocrine, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, China.

Objective: To evaluate the effectiveness of different glucose monitoring methods on blood glucose control and the incidence of adverse events among patients with type 1 diabetes mellitus.

Methods: Using the method of literature review, the databases PubMed, Cochrane, and Embase were retrieved to obtain relevant research literature, and the selected studies were analyzed and evaluated. This study used Cochrane software RevMan5. Read More

Front Immunol 2022 9;13:917577. Epub 2022 Jun 9.

Department of Respiratory and Critical Care Medicine, The Center for Biomedical Research, National Health Commission (NHC) Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.

Type 1 diabetes (T1D) stems from pancreatic β cell destruction by islet reactive immune cells. Similar as other autoimmune disorders, there is no curative remedy for T1D thus far. Chronic insulitis is the hallmark of T1D, which creates a local inflammatory microenvironment that impairs β cell function and ultimately leads to β cell death. Read More

Front Endocrinol (Lausanne) 2022 10;13:914136. Epub 2022 Jun 10.

National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.

Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells and is becoming a serious public health threat. Despite the increasing incidence rate of T1D worldwide, our understanding of why T1D develops and how T cells lose their self-tolerance in this process remain limited. Recent advances in immunometabolism have shown that cellular metabolism plays a fundamental role in shaping T cell responses. Read More

Nutrients 2022 Jun 16;14(12). Epub 2022 Jun 16.

Department of Bromatology and Nutrition Physiology, Institute of Animal Nutrition and Bromatology, University of Life Sciences in Lublin, Akademicka St. 13, 20-950 Lublin, Poland.

Type 1 diabetes mellitus (T1DM) is a disease marked by oxidative stress, chronic inflammation, and the presence of autoantibodies. The gut microbiota has been shown to be involved in the alleviation of oxidative stress and inflammation as well as strengthening immunity, thus its' possible involvement in the pathogenesis of T1DM has been highlighted. The goal of the present study is to analyze information on the relationship between the structure of the intestinal microbiome and the occurrence of T1DM. Read More

Cells 2022 06 18;11(12). Epub 2022 Jun 18.

KU Leuven, Laboratory of Molecular & Cellular Signaling, Department of Cellular & Molecular Medicine, Campus Gasthuisberg, O/N-I bus 802, Herestraat 49, BE-3000 Leuven, Belgium.

Calcium ions (Ca) operate as important messengers in the cell, indispensable for signaling the underlying numerous cellular processes in all of the cell types in the human body. In neurons, Ca signaling is crucial for regulating synaptic transmission and for the processes of learning and memory formation. Hence, the dysregulation of intracellular Ca homeostasis results in a broad range of disorders, including cancer and neurodegeneration. Read More

Arch Dis Child 2022 Jun 23. Epub 2022 Jun 23.

Paediatric Emergency Department, Sidra Medicine, Doha, Qatar.

Importance: Diabetic ketoacidosis (DKA) is a serious complication of type 1 diabetes mellitus, which may lead to significant morbidity and mortality.

Objectives: To compare the safety and efficacy of liberalised versus conservative intravenous fluid regimens in the management of DKA in children.

Data Source And Study Selection: Databases from inception to January 2022: MEDLINE, EMBASE, CINAHL and the Cochrane Central Register of Controlled Trials were included. Read More

Front Endocrinol (Lausanne) 2022 6;13:919942. Epub 2022 Jun 6.

Department of Endocrinology, St Vincent's Hospital, Sydney, NSW, Australia.

Closed-loop (artificial pancreas) systems for automated insulin delivery have been likened to the holy grail of diabetes management. The first iterations of glucose-responsive insulin delivery were pioneered in the 1960s and 1970s, with the development of systems that used venous glucose measurements to dictate intravenous infusions of insulin and dextrose in order to maintain normoglycemia. Only recently have these bulky, bedside technologies progressed to miniaturized, wearable devices. Read More

Front Bioeng Biotechnol 2022 26;10:809528. Epub 2022 May 26.

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.

Pre-eclampsia is a serious consideration for women with type 1 diabetes mellitus (T1DM) planning pregnancy. Risk stratification strategies, such as biomarkers measured in the first trimester of pregnancy, could help identify high-risk women. The literature on T1DM-specific pre-eclampsia biomarkers is expanding. Read More

Front Endocrinol (Lausanne) 2022 26;13:890090. Epub 2022 May 26.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background/aims: Currently, glycemic variability has more deleterious effects than sustained hyperglycemia and is closely associated with acute and chronic complications of diabetes. Reducing glycemic excursion is becoming another vital goal of glycemic control in clinical practice. This study aimed to determine whether insulin degludec (IDeg) or insulin glargine (IGla) was more beneficial for reducing glycemic fluctuations. Read More

Front Endocrinol (Lausanne) 2022 26;13:841256. Epub 2022 May 26.

Department of Anesthesiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

Background: Although a variety of data showing that diabetes mellitus (DM) (Type 1 or Type 2) is associated with postoperative complication, there is still a lack of detailed studies that go through the specific diabetic subgroups. The goal of this meta-analysis is to assess the relationship between DM and various complications after non-cardiac surgery.

Methods: We searched articles published in three mainstream electronic databases (PubMed, EMBASE, Web of science) before November, 2020. Read More

Front Endocrinol (Lausanne) 2022 30;13:878585. Epub 2022 May 30.

Center of Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Background: The role of metformin in the treatment of adolescents with type 1 diabetes mellitus (T1DM) remains controversial. We conducted this updated meta-analysis to generate a comprehensive assessment regarding the effect and safety of metformin in treating adolescents with T1DM.

Methods: We systematically searched PubMed, Embase, and the Cochrane Central Registry of Controlled Trials (CENTRAL) from their inception to November 2021 to identify randomized controlled trials evaluating the efficacy of metformin in the treatment of adolescents with T1DM. Read More

J Coll Physicians Surg Pak 2022 Jun;32(6):817-819

Department of Medicine, Fatima Memorial Hospital, College of Medicine and Dentistry, Lahore, Pakistan.

Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an inability to store fat in adipocytes. It is extremely rare. Read More

Global Health 2022 Jun 8;18(1):58. Epub 2022 Jun 8.

Shiraz Azad University, Dental Branch, Shiraz, Iran.

Background: Apart from infecting a large number of people around the world and causing the death of many people, the COVID-19 pandemic seems to have changed the healthcare processes of other diseases by changing the allocation of health resources and changing people's access or intention to healthcare systems.

Objective: To compare the incidence of endpoints marking delayed healthcare seeking in medical emergencies, before and during the pandemic.

Methods: Based on a PICO model, medical emergency conditions that need timely intervention was selected to be evaluated as separate panels. Read More

Diabetes Metab Res Rev 2022 Jun 8:e3555. Epub 2022 Jun 8.

Department of Paediatric, Aristotle University, Ippokration General Hospital, Thessaloniki, Greece.

Aims: Cardiovascular disease (CVD) represents the most frequent cause of morbidity and mortality among patients with type 1 diabetes mellitus (T1DM). Our aim was to review the evidence and conduct a meta-analysis assessing measures of arterial stiffness by pulse wave velocity (PWV) and augmentation index (AIx) in children and adolescents with T1DM compared to healthy controls.

Methods: PubMed and the Cochrane Library were searched for relevant studies published up to 10 May 2021. Read More

Cell Mol Life Sci 2022 Jun 8;79(7):351. Epub 2022 Jun 8.

Epigenetics in Human Health and Disease, Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.

Mapping a new therapeutic route can be fraught with challenges, but recent developments in the preparation and properties of small particles combined with significant improvements to tried and tested techniques offer refined cell targeting with tremendous translational potential. Regenerating new cells through the use of compounds that regulate epigenetic pathways represents an attractive approach that is gaining increased attention for the treatment of several diseases including Type 1 Diabetes and cardiomyopathy. However, cells that have been regenerated using epigenetic agents will still encounter immunological barriers as well as limitations associated with their longevity and potency during transplantation. Read More

J Diabetes Metab Disord 2022 Jun 24;21(1):1081-1094. Epub 2022 Feb 24.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health Central South University, Hunan Province 410078, Changsha, People's Republic of China.

Abstract: Type 1 diabetes mellitus (T1DM) is one of the most common chronic immune-mediated diseases. The prevalence is worldwide especially among children and young adults. The destruction of the pancreatic β-cells due to some abnormalities in the immune system characterizes T1DM. Read More

Curr Osteoporos Rep 2022 Jun 8;20(3):194-201. Epub 2022 Jun 8.

Department of Medicine III and Center for Healthy Aging, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.

Purpose Of Review: The incidence of diabetes is increasing worldwide. Diabetes mellitus is characterized by hyperglycemia, which in the long-term damages the function of many organs including the eyes, the vasculature, the nervous system, and the kidneys, thereby imposing an important cause of morbidity for affected individuals. More recently, increased bone fragility was also noted in patients with diabetes. Read More

Diabetes Metab Syndr 2022 Jun 27;16(6):102512. Epub 2022 May 27.

Department of Basic Sciences and New Technologies, Electronical Branch, Islamic Azad University, Tehran, Iran.

Background And Aims: This systematic review and meta-analysis aimed to evaluate the current evidence available to investigate clinical outcomes between patients with type 1 and type 2 diabetes.

Methods: MEDLINE (Pubmed), Scopus, Web of Science, Cochrane library, Google scholar and Clinicaltrials.gov were searched. Read More

BMC Ophthalmol 2022 Jun 4;22(1):250. Epub 2022 Jun 4.

Laboratory of Human Molecular Genetics, Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde (PPGBioSaúde), Universidade Luterana do Brasil (ULBRA), Av. Farroupilha, 8001, Prédio 22, 5° andar, Canoas, RS, 92425-900, Brazil.

Background: Diabetic retinopathy (DR) is characterized by ischemia, hypoxia, and angiogenesis. Erythropoietin (EPO), an angiogenic hormone, is upregulated in DR, and the association of EPO genetic variants with DR is still uncertain, as conflicting results have been reported. Therefore, we performed a case-control study followed by a meta-analysis to investigate whether the rs1617640, rs507392, and rs551238 polymorphisms in EPO gene are associated with DR. Read More

Eur J Sport Sci 2022 Jun 24:1-12. Epub 2022 Jun 24.

Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain.

The aim of the study is to evaluate whether exercise interventions are associated with improved glycaemic control in children and adolescents with type 1 diabetes mellitus (T1DM), and to examine its relationship with the characteristics of the intervention (i.e. type, intensity, length, and duration of the sessions). Read More

Curr Diabetes Rev 2022 Jun 1. Epub 2022 Jun 1.

Department of Human Nutrition, College of Health Sciences, Qatar University. Doha 2713 Qatar.

Celiac disease is diagnosed more commonly with type 1 diabetes, and the most problematic aspect for a child with type 1 diabetes and celiac disease is that most GFD foods have a high glycemic index, while low glycemic index foods are recommended for type 1 diabetes mellitus. As a result, dietary controls becomes more difficult. Diet management could improve the elevated HbA1c levels. Read More

Nat Rev Endocrinol 2022 Jun 1. Epub 2022 Jun 1.

Laboratoire de Virologie ULR3610, Université de Lille, CHU Lille, Lille, France.

Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and type 1 diabetes mellitus (T1DM). Although enteroviruses are primarily involved in acute and lytic infections in vitro and in vivo, they can also establish a persistent infection. Prospective epidemiological studies have strongly associated the persistence of enteroviruses, especially coxsackievirus B (CVB), with the appearance of islet autoantibodies and an increased risk of T1DM. Read More

Curr Diab Rep 2022 Jul 1;22(7):275-281. Epub 2022 Jun 1.

Department of Medicine, Division of Endocrinology, North Shore University Hospital, Manhasset, NY, USA.

Purpose Of Review: The management of diabetes has been revolutionized by the introduction of novel technological treatments and modalities of care, such as continuous glucose monitoring, insulin pump therapy, and telehealth. While these technologies have demonstrated improvement in health outcomes, it remains unclear whether they have reduced inequities from racial/ethnic minority or socioeconomic status. We review the current literature to discuss evidence of benefit, current limitations, and future opportunities of diabetes technologies. Read More

Front Pharmacol 2022 11;13:887298. Epub 2022 May 11.

National Institute for Health and Care Excellence (NICE), London, United Kingdom.

In the UK, 4.7 million people are currently living with diabetes. This is projected to increase to 5 million by 2025. Read More

Curr Diab Rep 2022 Jul 28;22(7):317-332. Epub 2022 May 28.

Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada.

Purpose Of Review: The aim of this review is to summarize existing research investigating the use of sodium glucose cotransporter-2 (SGLT2) inhibitors in patients with type 1 diabetes mellitus (T1DM) while highlighting potential strategies to mitigate the risk of diabetic ketoacidosis (DKA).

Recent Findings: SGLT2 inhibitors have been studied in patients with T1DM in phase 3 clinical trials such as the inTandem, DEPICT, and EASE trials, which demonstrated consistent reductions in HbA1c. Secondary analyses of these trials have also reported potential kidney protective effects that are independent of improved glycemic control. Read More

BMC Endocr Disord 2022 May 25;22(1):138. Epub 2022 May 25.

Department of Health Sciences, Faculty for Health, Science And Technology, Karlstad University, Karlstad, Sweden.

Background: Individually designed interventions delivered through mobile health applications (mHealth apps) may be able to effectively support diabetes self-care. Our aim was to review and synthesize available evidence in the literature regarding perception of adults with type 1 diabetes on the features of mHealth apps that help promote diabetes self-care, as well as facilitators and barriers to their use. An additional aim was to review literature on changes in patient reported outcome measures (PROMs) in the same population while using mHealth apps for diabetes self-care. Read More

Biosens Bioelectron 2022 Sep 13;211:114348. Epub 2022 May 13.

Department of Industrial, Electronic and Mechanical Engineering, University of Roma Tre, Via Vito Volterra, 62, 00146, Rome, Italy. Electronic address:

the work has been aimed to create an overview of available and used methods and ways to determine the concentration of glucose in body fluids, especially from a technical point of view. It also provides an overview of the clinical features of these methods. The survey found that today's market offers a large number of options and approaches to the issue. Read More

Accid Anal Prev 2022 Aug 20;173:106692. Epub 2022 May 20.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, United States.

Background: Diabetes is a major public health challenge, affecting millions of people worldwide. Abnormal physiology in diabetes, particularly hypoglycemia, can cause driver impairments that affect safe driving. While diabetes driver safety has been previously researched, few studies link real-time physiologic changes in drivers with diabetes to objective real-world driver safety, particularly at high-risk areas like intersections. Read More

Front Immunol 2022 4;13:886736. Epub 2022 May 4.

Laboratory of Immunomodulation and Regenerative Cell Therapy, Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands.

Type 1 diabetes (T1D) is an autoimmune disease that develops in the interplay between genetic and environmental factors. A majority of individuals who develop T1D have a HLA make up, that accounts for 50% of the genetic risk of disease. Besides these HLA haplotypes and the insulin region that importantly contribute to the heritable component, genome-wide association studies have identified many polymorphisms in over 60 non-HLA gene regions that also contribute to T1D susceptibility. Read More

J Diabetes Res 2022 12;2022:2650342. Epub 2022 May 12.

University of Kentucky, Barnstable Brown Diabetes Center, Lexington, KY, USA.

Type 1 diabetes is associated with complications affecting muscle and bone, with diabetic bone disease and diabetic myopathy becoming increasingly reported in the past few decades. This review is aimed at succinctly reviewing the literature on the current knowledge regarding these increasingly identified and possibly interconnected complications on the musculoskeletal system. Furthermore, this review summarizes several nonmechanical factors that could be mediating the development and progression of premature musculoskeletal decline in this population and discusses preventative measures to reduce the burden of diabetes on the musculoskeletal system. Read More