BMC Ophthalmol 2022 Jun 4;22(1):250. Epub 2022 Jun 4.
Laboratory of Human Molecular Genetics, Programa de Pós-Graduação em Biologia Celular e Molecular Aplicada à Saúde (PPGBioSaúde), Universidade Luterana do Brasil (ULBRA), Av. Farroupilha, 8001, Prédio 22, 5° andar, Canoas, RS, 92425-900, Brazil.
Background: Diabetic retinopathy (DR) is characterized by ischemia, hypoxia, and angiogenesis. Erythropoietin (EPO), an angiogenic hormone, is upregulated in DR, and the association of EPO genetic variants with DR is still uncertain, as conflicting results have been reported. Therefore, we performed a case-control study followed by a meta-analysis to investigate whether the rs1617640, rs507392, and rs551238 polymorphisms in EPO gene are associated with DR. Read More