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    70155 results match your criteria Diabetes Mellitus Type 1

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    Laparoscopic Sleeve Gastrectomy for the Management of Type 1 Diabetes Mellitus.
    Obes Surg 2017 Jun 26. Epub 2017 Jun 26.
    Al Amiri Hospital, Kuwait City, Kuwait.
    Background: The prevalence of obesity is on a continuous rise worldwide, with major studies clearly correlating obesity with the development of chronic metabolic disorders including type 2 diabetes. Bariatric surgery has proven to be beneficial in the management of this condition; however, a limited number of studies exist on its effect on type 1 diabetes.

    Objective: The objective of this study is to evaluate the outcome of laparoscopic sleeve gastrectomy for the management of patients with type 1 diabetes (DM1). Read More

    Streptozocin-induced Type-1 diabetes mellitus results in decreased density of cgrp sensory and th sympathetic nerve fibers that are positively correlated with bone loss at the mouse femoral neck.
    Neurosci Lett 2017 Jun 23. Epub 2017 Jun 23.
    Unidad Académica Multidisciplinaria Reynosa Aztlán, Universidad Autónoma de Tamaulipas, Reynosa, Tamaulipas, 88740, México.
    Type-1 diabetes mellitus (T1DM) results in loss of innervation in some tissues including epidermis and retina; however, the effect on bone innervation is unknown. Likewise, T1DM results in pathological bone loss and increased risk of fracture. Thus, we quantified the density of calcitonin gene-related peptide (CGRP(+)) sensory and tyrosine hydroxylase (TH(+)) sympathetic nerve fibers and determined the association between the innervation density and microarchitecture of trabecular bone at the mouse femoral neck. Read More

    Repeated Paradoxical Brain Infarctions in a Patient on Self-Managed Home Hemodialysis Using a Long-Term Indwelling Catheter.
    J Stroke Cerebrovasc Dis 2017 Jun 23. Epub 2017 Jun 23.
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    We describe the case of a 51-year-old Japanese man with an end-stage kidney disease caused by a 30-year history of type 1 diabetes mellitus. The patient had suffered repeated bilateral multiple brain infarctions within a short period of time after the initiation of a self-managed daily home hemodialysis regimen using a long-term indwelling catheter inserted into the right atrium. Despite extensive examinations, we could not find any embolic causes except for the catheter and a patent foramen ovale (PFO). Read More

    Evaluation of the effectiveness and cost-effectiveness of lightweight fibreglass heel casts in the management of ulcers of the heel in diabetes: a randomised controlled trial.
    Health Technol Assess 2017 May;21(34):1-92
    Swansea Centre for Health Economics, College of Human and Health Science, Swansea University, Swansea, UK.
    Background: Ulcers of the foot in people with diabetes mellitus are slow to heal and result in considerable cost and patient suffering. The prognosis is worst for ulcers of the heel.

    Objective: To assess both the clinical effectiveness and the cost-effectiveness of lightweight fibreglass casts in the management of heel ulcers. Read More

    A case report of hyperosmolar hyperglycemic state in a 7-year-old child: An unusual presentation of first appearance of type 1 diabetes mellitus.
    Medicine (Baltimore) 2017 Jun;96(25):e7369
    Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
    Rationale: A hyperosmolar hyperglycemic state (HHS) is a rare presentation of a hyperglycemic crisis in children with diabetes mellitus. As this condition can be fatal and has high morbidity, early recognition and proper management are necessary for a better outcome. Here, we report a rare case of HHS as the first presentation of type 1 diabetes mellitus (T1DM) in a 7-year-old girl. Read More

    Whole lipid profile and not only HDL cholesterol is impaired in children with coexisting type 1 diabetes and untreated celiac disease.
    Acta Diabetol 2017 Jun 21. Epub 2017 Jun 21.
    Pediatric Clinic, Insubria University, Varese, Italy.
    Aims: Low HDL cholesterol (HDL-C) levels have been described in patients with coexisting type 1 diabetes mellitus (T1DM) and celiac disease (CD). Data on other possible lipid abnormalities that could further increase cardiovascular risk in these patients are scarce and incomplete. Aim of this retrospective multicenter study was to evaluate whole lipid profiles, besides HDL-C, in children with T1DM associated with biopsy-proven CD, and to investigate the influence of age and degree of adherence to gluten-free diet (GFD) on lipid changes. Read More

    Oral Insulin: Myth or Reality.
    Curr Diabetes Rev 2017 Jun 21. Epub 2017 Jun 21.
    Department of Pharmaceutical Sciences, Dr. H. S. Gour Central University, Sagar, 470003, (MP). India.
    Background: Diabetes mellitus (DM) is a disorder of glucose metabolism marked by hyperglycemia, glycosuria, hyperlipidemia, negative nitrogen balance and ketonaemia. DM is a major healthcare problems today and its treatment costs billions of dollars worldwide annually. The cases of diabetes have increased rapidly in recent years throughout the world. Read More

    Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia.
    Exp Biol Med (Maywood) 2017 Jan 1:1535370217716424. Epub 2017 Jan 1.
    2 Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
    Individuals with diabetes mellitus suffer from impaired angiogenesis and this contributes to poorer peripheral arterial disease outcomes. In experimental peripheral arterial disease, angiogenesis and perfusion recovery are impaired in mice with diabetes. We recently showed that a disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) is upregulated in ischemic endothelial cells and plays a key role in post-ischemic angiogenesis and perfusion recovery following experimental peripheral arterial disease. Read More

    Estrogen receptor α gene polymorphism and vascular complications in girls with type 1 diabetes mellitus.
    Mol Cell Biochem 2017 Jun 20. Epub 2017 Jun 20.
    Chair & Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211, Gdańsk, Poland.
    The effect of estrogens is mediated by activation of estrogen receptors (ERs). Because ER-α gene polymorphisms may exert different effects in childhood, we analyzed the associations between the IVS1 -397T>C (PvuII) polymorphism and systemic inflammatory state, proangiogenic factors, frequency of monocyte subsets, lipid profile, blood pressure, and vascular complications in girls with type 1 diabetes mellitus (DM1). We examined 180 young girls with DM1 and 120 healthy age-matched controls. Read More

    Risk of allergic conjunctivitis in patients with type 1 diabetes mellitus: a population-based retrospective cohort study.
    BMJ Open 2017 Jun 19;7(6):e015795. Epub 2017 Jun 19.
    Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, Taichung, Taiwan.
    Objective: In accordance with the dichotomy between T helper type 1(Th1) and T helper type 2 (Th2) responses, the occurrence of allergic conjunctivitis (AC) and type 1 diabetes mellitus (T1DM) is, in theory, inversely related in the individual. However, recent studies investigating the association between the two diseases are controversial.

    Design: Population-based cohort study. Read More

    A Mobile App for the Self-Management of Type 1 Diabetes Among Adolescents: A Randomized Controlled Trial.
    JMIR Mhealth Uhealth 2017 Jun 19;5(6):e82. Epub 2017 Jun 19.
    Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada.
    Background: While optimal blood glucose control is known to reduce the long-term complications associated with type 1 diabetes mellitus, adolescents often struggle to achieve their blood glucose targets. However, their strong propensity toward technology presents a unique opportunity for the delivery of novel self-management interventions. To support type 1 diabetes self-management in this population, we developed the diabetes self-management app bant, which included wireless blood glucose reading transfer, out-of-range blood glucose trend alerts, coaching around out-of-range trend causes and fixes, and a point-based incentive system. Read More

    Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset.
    Arch Oral Biol 2017 Jun 12;82:115-120. Epub 2017 Jun 12.
    Division of Periodontology, Malatya Oral and Dental Health Hospital, The Turkish Ministry of Health, Malatya, Turkey.
    Objective: Recently, increasing concern has been focused on the contribution of oxidative stress in the pathology of periodontal disease and diabetes mellitus. Firstly, the present study aimed to analyze gingival crevicular fluid (GCF), salivary, and serum oxidative status in children with type 1 diabetes mellitus (T1DM) at diagnosis and systemically healthy children with and without gingivitis. Additionally, the diabetic patients were reevaluated after diabetes and periodontal treatment. Read More

    Exploring the Frequency Domain of Continuous Glucose Monitoring Signals to Improve Characterization of Glucose Variability and of Diabetic Profiles.
    J Diabetes Sci Technol 2017 Jan 1:1932296816685717. Epub 2017 Jan 1.
    1 Life Supporting Technologies, Departamento de Tecnología Fotónica y Bioingeniería, Universidad Politécnica de Madrid, Ciudad Universitaria, Madrid, Spain.
    Background: Continuous glucose monitoring (CGM) devices measure interstitial glucose concentrations (normally every 5 minutes), allowing observation of glucose variability (GV) patterns during the whole day. This information could be used to improve prescription of treatments and of insulin dosages for people suffering diabetes. Previous efforts have been focused on proposing indices of GV either in time or glucose domains, while the frequency domain has been explored only partially. Read More

    Insulinotropic action of 2, 4-dinitroanilino-benzoic acid through the attenuation of pancreatic beta-cell lesions in diabetic rats.
    Chem Biol Interact 2017 Jun 15. Epub 2017 Jun 15.
    H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
    Beta cell destruction plays a key role in the pathogenesis of type 1 diabetes mellitus. It has also been argued that beta cell mass may also be compromised in some cases of type 2 diabetes, although this is controversial. Currently, the failure of oral antidiabetic insulin secretagogue drugs to properly correct type 2 diabetes demands novel approaches in the treatment of this condition. Read More

    Basal and Bolus Insulin Dose Changes after Switching Basal Insulin to Insulin Degludec in Patients with Type 1 Diabetes Mellitus: A Pilot Study.
    Clin Drug Investig 2017 Jun 17. Epub 2017 Jun 17.
    Center for Diabetes and Endocrinology, The Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Osaka, Japan.
    Background And Objectives: Ultra-long-acting insulin degludec (DEG) has a longer duration of action and less daily variability relative to other basal insulin (BI), and thus may benefit patients with type 1 diabetes mellitus (T1DM). We examined the impact of switching BI to DEG on glycemic control and insulin dose in T1DM.

    Methods: T1DM patients (n = 22; six male; mean age: 64. Read More

    Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity.
    J Autoimmun 2017 Jun 14. Epub 2017 Jun 14.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Israel. Electronic address:
    Autoimmune diseases (ADs) are a heterogeneous groups of diseases that occur as a results of loss of tolerance to self antigens. While the etiopathogeneis remain obscure, different environmental factors were suggested to have a role in the development of autoimmunity, including infections, low vitamin D levels, UV radiation, and melatonin. Interestingly, such factors possess seasonal variation patterns that could influence disease development, severity and progression. Read More

    Relative amount of telomeric sequences in terminal villi does not differ between normal term placentas and placentas from patients with well-controlled type 1 diabetes mellitus.
    Placenta 2017 Jul 21;55:1-4. Epub 2017 Apr 21.
    Department of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, 128 00 Prague, Czech Republic. Electronic address:
    We applied qPCR to compare relative telomere length in terminal villi microdissected from term control placentas and placentas of patients suffering from type 1 diabetes. Significant differences were not found in the relative T/S ratios between placental groups or between the diabetic placentas affected and those not affected with chorangiosis. We hypothesize that there is no relationship between decreased placental proliferative ability in maternal diabetes type 1 and telomere shortening. Read More

    NGAL as an Early Predictive Marker of Diabetic Nephropathy in Children and Young Adults with Type 1 Diabetes Mellitus.
    J Diabetes Res 2017 15;2017:7526919. Epub 2017 May 15.
    Department of Endocrinology, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden.
    Aims: Type 1 diabetes (T1D) is often associated with early microvascular complications. Previous studies demonstrated that increased systolic (SAP) and diastolic arterial blood pressures (DAP) are linked to microvascular morbidity in T1D. The aim of the study was to investigate the predictive role of neutrophil gelatinase-associated lipocalin (NGAL) in unravelling early cardio-renal dysfunction in T1D. Read More

    Glycemic variability and insulin needs in patients with type 1 diabetes mellitus supplemented with vitamin D: a pilot study using continuous glucose monitoring system.
    Curr Diabetes Rev 2017 Jun 15. Epub 2017 Jun 15.
    University Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Mundurucus Street, 4487, Guamá, Belém, Pará. Brazil.
    Background: Recent studies suggest that glycemic variability could influence the risk of complications in type 1 diabetes mellitus (T1DM). There are no data about the action of vitamin D (VD) on glycemic variability. Our pilot study aims to evaluate glycemic variability and insulin needs in patients with T1DM supplemented with VD. Read More

    Evaluation of polyneuropathy and associated risk factors in children with type 1 diabetes mellitus.
    Turk J Med Sci 2017 Jun 12;47(3):942-946. Epub 2017 Jun 12.
    Department of Pediatric Neurology, Dr. Behçet Uz Children's Training and Research Hospital, İzmir, Turkey.
    Background/aim: Diabetes mellitus (DM) is one of the most common metabolic diseases seen in the world today. Diabetic neuropathy (DN) is a chronic complication of the disease that is rarely reported in children, since it has a relatively longer latency period. Our main objective in this study is to determine the incidence rate of DN in pediatric DM patients and assess the risk factors associated with DN. Read More

    Stem cells: An emerging novel therapeutic for type-1 diabetes mellitus.
    Diabetes Res Clin Pract 2017 Apr 19;130:130-132. Epub 2017 Apr 19.
    Department of Regenerative Medicine and Stem Cell Therapy and Pediatrics, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC), Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), India; Department of Nephrology and Transplantation Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC), Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), India.
    Stem cell based strategies are therapeutically potent for treating type-1 diabetes mellitus owing to their intrinsic regenerative capacity and immunomodulatory properties to arrest autoimmune β-cell destruction, preserve residual β-cell mass, facilitate endogenous regeneration, ameliorate innate/ alloimmune graft rejection, restore β-cell-specific unresponsiveness in absence of chronic immunosuppression and to reverse hyperglycemia. Read More

    Effects of Insulin Plus Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) in Treating Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
    Diabetes Ther 2017 Jun 14. Epub 2017 Jun 14.
    Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
    Introduction: Combination therapy with insulin and glucagon-like peptide-1 receptor agonists (GLP-1RAs) has already been proven an efficient treatment option for type 2 diabetes. This combination can effectively improve glycated hemoglobin levels, cause weight loss and reduce the dosage of insulin. In addition, it can also reduce the risk of hypoglycemia. Read More

    Retinal Ganglion Cell Loss in Children With Type 1 Diabetes Mellitus Without Diabetic Retinopathy.
    Ophthalmic Surg Lasers Imaging Retina 2017 Jun;48(6):473-477
    Background And Objective: Early diabetic retinal changes in children with type 1 diabetes mellitus (T1DM) without diabetic retinopathy (DR) were examined using spectral-domain optical coherence tomography (SD-OCT).

    Patients And Methods: Sixty children with T1DM without DR and 60 normal children were enrolled in the study. SD-OCT was used to measure the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber (RNFL) thicknesses in all participants. Read More

    Telemedicine for the Management of Glycemic Control and Clinical Outcomes of Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.
    Front Pharmacol 2017 30;8:330. Epub 2017 May 30.
    Faculty of Pharmacy, UCSI UniversityKuala Lumpur, Malaysia.
    Importance: Telemedicine has been shown to be an efficient and effective means of providing care to patients with chronic disease especially in remote and undeserved regions, by improving access to care and reduce healthcare cost. However, the evidence surrounding its applicability in type 1 diabetes remains scarce and conflicting. Objective: To synthesize evidence and quantify the effectiveness of telemedicine interventions for the management of glycemic and clinical outcomes in type 1 diabetes patients, relative to comparator conditions. Read More

    Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative.
    Sci Rep 2017 Jun 12;7(1):3313. Epub 2017 Jun 12.
    Department of Medical Sciences, Scientific Institute "Casa Sollievo della Sofferenza", San Giovanni Rotondo (FG), Italy.
    We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR), urinary albumin excretion, HbA1c, lipids, blood pressure. Over a 5-year period 4. Read More

    Effects of exogenous human insulin dose adjustment on body mass index in adult patients with type 1 diabetes mellitus at Kalafong Hospital, Pretoria, South Africa, 2009 - 2014.
    S Afr Med J 2017 May 24;107(6):528-534. Epub 2017 May 24.
    National Department of Health, Pretoria, South Africa; School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, South Africa.
    Background: To maintain fasting blood glucose levels within near to the normal range in type 1 diabetes mellitus (DM), frequent insulin dose adjustments may be required with short-, intermediate- and long-acting insulin formulations. Patients on human insulin generally experience weight gain over time, regardless of the level of glycaemic control achieved.

    Objectives: To determine the effects of human insulin, adjusted quarterly to achieve glycaemic control, on body mass index (BMI), and establish dose regimens that achieve optimal glycaemic control without increasing BMI in patients with type 1 DM at the Kalafong Diabetes Clinic in Pretoria, South Africa. Read More

    Techniques of monitoring blood glucose during pregnancy for women with pre-existing diabetes.
    Cochrane Database Syst Rev 2017 Jun 11;6:CD009613. Epub 2017 Jun 11.
    Institute of Psychology, Health and Society, The University of Liverpool, Liverpool, UK.
    Background: Self-monitoring of blood glucose (SMBG) is recommended as a key component of the management plan for diabetes therapy during pregnancy. No existing systematic reviews consider the benefits/effectiveness of various techniques of blood glucose monitoring on maternal and infant outcomes among pregnant women with pre-existing diabetes. The effectiveness of the various monitoring techniques is unclear. Read More

    Level of Internet use among Greek adolescents with type 1 diabetes.
    Int J Adolesc Med Health 2017 Jun 9. Epub 2017 Jun 9.
    Background Compulsive Internet use has emerged as a contemporary addictive behavior. Our aim was to investigate the reasons for Greek adolescents with type 1 diabetes mellitus (T1DM) and their families to use the Internet and additionally to investigate the level of Internet use and its associations to demographic, socio-economic parameters and glycemic control. Methods Patients with T1DM, aged >12 years and their parents were recruited during their regular visits to the Pediatric Diabetes Clinic. Read More

    GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus.
    Acta Diabetol 2017 Jun 9. Epub 2017 Jun 9.
    Endocrine Division, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, Prédio 12, 4º andar, Zip Code: 90035-003, Porto Alegre, Rio Grande do Sul, Brazil.
    Aims: The transcription factor Gli-similar 3 (GLIS3) plays a key role in the development and maintenance of pancreatic beta cells as well as in the regulation of Insulin gene expression in adults. Accordingly, genome-wide association studies identified GLIS3 as a susceptibility locus for type 1 diabetes mellitus (T1DM) and glucose metabolism traits. Therefore, the aim of this study was to replicate the association of the rs10758593 and rs7020673 single nucleotide polymorphisms (SNPs) in the GLIS3 gene with T1DM in a Brazilian population. Read More

    The beneficial effects of zinc on diabetes-induced kidney damage in murine rodent model of type 1 diabetes mellitus.
    J Trace Elem Med Biol 2017 Jul 12;42:1-10. Epub 2017 Mar 12.
    The Department of Nephropathy, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China. Electronic address:
    Diabetes mellitus is a chronic multi-factorial metabolic disorder resulting from impaired glucose homeostasis. Zinc is a key co-factor for the correct functioning of anti-oxidant enzymes. Zinc deficiency therefore, impairs their synthesis, leading to increased oxidative stress within cells. Read More

    Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota.
    J Autoimmun 2017 Jun 4. Epub 2017 Jun 4.
    Section of Endocrinology, School of Medicine, Yale University, New Haven, CT, 06519, USA; Key Laboratory of Diabetes Immunology, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. Electronic address:
    Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor. To investigate the role of Nod2 in susceptibility to the autoimmune disease, type 1 diabetes mellitus (T1DM), we generated Nod2(-/-) non-obese diabetic (NOD) mice. The Nod2(-/-)NOD mice had different composition of the gut microbiota compared to Nod2(+/+)NOD mice and were significantly protected from diabetes, but only when housed separately from Nod2(+/+)NOD mice. Read More

    [Effect of the use of antibiotics controlled by clinical pharmacist in patients with diabetic ketoacidosis].
    Zhonghua Er Ke Za Zhi 2017 Jun;55(6):415-418
    Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
    Objective: To analyze the effect of the use of antibiotics intervened by clinical pharmacist in diabetic ketoacidosis (DKA) patients. Method: This was a prospective clinical study with a historical control group.The group 1 was the control group which was not intervened for antibiotics use from January 2010 to November 2012. Read More

    Environmental Factors Associated with Type 1 Diabetes Development: A Case Control Study in Egypt.
    Int J Environ Res Public Health 2017 Jun 7;14(6). Epub 2017 Jun 7.
    Department of Pediatrics, Faculty of Medicine (for girls), Al-Azhar University, Cairo 11651, Egypt.
    Uncertainty still exists regarding the role of some environmental risk in the development of type 1 diabetes mellitus (T1DM) both globally and in Egypt. The objective here was to explore the potential environmental risk factors associated with the development of T1DM among children in Egypt. A case-controlled study of 204 T1DM children and an equal number of age and sex-matched controls was conducted in Assiut, Egypt. Read More

    Gender, alexithymia and physical inactivity associated with abdominal obesity in type 1 diabetes mellitus: a cross sectional study at a secondary care hospital diabetes clinic.
    BMC Obes 2017 2;4:21. Epub 2017 Jun 2.
    Department of Clinical Sciences, Diabetes Research Laboratory, Lund University, Faculty of Medicine, Lund, Sweden.
    Background: Obesity is linked to cardiovascular diseases and increasingly common in type 1 diabetes mellitus (T1DM) since the introduction of intensified insulin therapy. Our main aim was to explore associations between obesity and depression, anxiety, alexithymia and self-image measures and to control for lifestyle variables in a sample of persons with T1DM. Secondary aims were to explore associations between abdominal and general obesity and cardiovascular complications in T1DM. Read More

    Dapagliflozin for the treatment of type 1 diabetes mellitus.
    Expert Opin Investig Drugs 2017 Jul 12;26(7):873-881. Epub 2017 Jun 12.
    a Diabetes Centre, Second Department of Internal Medicine , Democritus University of Thrace, University Hospital of Alexandroupolis , Alexandroupolis , Greece.
    Introduction: In 2017, the management of type 1 diabetes mellitus (T1DM) remains intriguing for the clinician, who has to balance between adequate glycemic control and untoward events related to insulin up-titration. Thus, agents that will complement insulin actions and reduce adverse effects are highly welcome. Areas covered: In this review, the authors summarize results from studies on the sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin in T1DM. Read More

    Thyroid Disease and Type 1 Diabetes in Dutch Children: A Nationwide Study (Young Dudes-3).
    J Pediatr 2017 Jun 2. Epub 2017 Jun 2.
    Princess Amalia Children's Centre, Isala, Zwolle, The Netherlands; University Medical Center and University of Groningen Postgraduate School of Medicine, University Medical Center and University of Groningen, The Netherlands.
    Objective: To investigate the prevalence of overt thyroid disease in children in The Netherlands with and without type 1 diabetes mellitus (T1DM).

    Study Design: Nationwide, retrospective cohort study in The Netherlands. Using the national registry of both healthcare reimbursement and pharmaceutical care, data of all Dutch children (aged 0-14 years) with a diagnosis of T1DM, or a diagnosis of hypothyroidism or hyperthyroidism in the period 2009-2011. Read More

    Genome-wide gene expression profiling reveals that CD274 is up-regulated new-onset type 1 diabetes mellitus.
    Acta Diabetol 2017 Jun 2. Epub 2017 Jun 2.
    Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, China.
    Aims: Early studies have identified type 1 diabetes mellitus (T1DM) as a disease that is caused by the autoimmune destruction of the insulin-producing pancreatic β-cells. Genetics, environment and the immune pathogenesis of T1DM are three major pillars of T1DM research. We try to understand the changes in the gene expression profile during the pathogenesis of T1DM. Read More

    Coexistence of celiac disease & type 1 diabetes mellitus in children.
    Indian J Med Res 2017 Jan;145(1):28-32
    Department of Pediatrics, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, India.
    Background & Objectives: Type 1 diabetes mellitus (T1DM) and celiac disease (CD) tend to co-exist due to similar underlying genetic predisposition. Failure to recognize CD in patients with T1DM predisposes them to complications. The present study was aimed to assess children with T1DM for the presence of CD. Read More

    Autoantibodies against voltage-gated potassium channel (VGKC) and glutamic acid decarboxylase (GAD) in psychosis: A systematic review, meta-analysis and case series.
    Psychiatry Clin Neurosci 2017 Jun 2. Epub 2017 Jun 2.
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
    Antibodies to the voltage-gated potassium channel (VGKC) complex and glutamic acid decarboxylase (GAD) have been reported in some cases of psychosis. We conducted the first systematic review and meta-analysis to investigate their prevalence in people with psychosis and report a case series of VGKC-complex antibodies in refractory psychosis. Only five studies presenting prevalence rates of VGKC seropositivity in psychosis were identified, in addition to our case series, with an overall prevalence of 1. Read More

    Projected Long-Term Outcomes in Patients With Type 1 Diabetes Treated With Fast-Acting Insulin Aspart Versus Conventional Insulin Aspart in the Uk Setting.
    Diabetes Obes Metab 2017 Jun 1. Epub 2017 Jun 1.
    Ossian Health Economics and Communications, Basel, Switzerland.
    Aims: Many patients with type 1 diabetes mellitus (T1DM) fail to achieve optimal glycemic control and mealtime insulins that more closely match physiological insulin secretion can help improve treatment. In the onset 1 trial, fast-acting insulin aspart (faster aspart) was shown to improve glycemic control in patients with T1DM compared with conventional insulin aspart (insulin aspart). In the UK, faster aspart and insulin aspart are associated with the same acquisition cost, and therefore the present analysis assessed the impact of faster aspart versus insulin aspart on long-term clinical outcomes and costs for patients with T1DM in the UK setting. Read More

    The Effect of Metformin as an Adjunct Therapy in Adolescents with Type 1 Diabetes.
    J Clin Diagn Res 2017 Apr 1;11(4):SC01-SC04. Epub 2017 Apr 1.
    PhD Candidate of Nutrition, Department of Clinical Nutrition, Nutrition and Food Sciences Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.
    Introduction: The strict control of blood glucose levels in adolescents with Type 1 Diabetes Mellitus (T1DM) is accompanied with a considerable long term decrease in microvasular and macrovascular complications.

    Aim: This study was conducted to investigate the effect of metformin as an adjunct therapy in adolescents with poorly controlled Type 1 diabetes.

    Materials And Methods: It was a quasi-experimental (an uncontrolled before and after) study. Read More

    Exploring factors influencing HbA1c and psychosocial outcomes in people with type 1 diabetes after training in advanced carbohydrate counting.
    Diabetes Res Clin Pract 2017 May 19;130:61-66. Epub 2017 May 19.
    Department of Endocrinology, Hvidovre University Hospital, Hvidovre, Denmark.
    Aims: The purpose of this secondary analysis of the StenoABC Study was to identify determinants of the changes in HbA1c observed after training of people with type 1 diabetes in advanced carbohydrate counting (ACC) and automated bolus calculator (ABC) use, and further to investigate psychosocial effects of these insulin dosing approaches.

    Methods: Validated diabetes-specific questionnaires were used to assess diabetes treatment satisfaction, problem areas in diabetes, fear of hypoglycemia and diabetes dependent quality of life before and one year after the training. In addition, numeracy was tested (using a non-validated test developed specifically for this study) and behavioral measures (number of daily blood glucose measurements and self-reported use of ACC) were obtained. Read More

    Clinical Impact of Blood Glucose Monitoring Accuracy: An In-Silico Study.
    J Diabetes Sci Technol 2017 May 1:1932296817710474. Epub 2017 May 1.
    1 Center for Diabetes Technology, University of Virginia, Charlottesville, VA, USA.
    Background: Patients with diabetes rely on blood glucose (BG) monitoring devices to manage their condition. As some self-monitoring devices are becoming more and more accurate, it becomes critical to understand the relationship between system accuracy and clinical outcomes, and the potential benefits of analytical accuracy.

    Methods: We conducted a 30-day in-silico study in type 1 diabetes mellitus (T1DM) patients using continuous subcutaneous insulin infusion (CSII) therapy and a variety of BG meters, using the FDA-approved University of Virginia (UVA)/Padova Type 1 Simulator. Read More

    GAD antibody-associated limbic encephalitis in a young woman with APECED.
    Endocrinol Diabetes Metab Case Rep 2017 25;2017. Epub 2017 May 25.
    Max Planck Institute of Psychiatry, Clinical Neuroendocrinology Group, MunichGermany.
    The autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome is a genetic disorder caused by a mutation in the autoimmune regulator (AIRE) gene. Immune deficiency, hypoparathyroidism and Addison's disease due to autoimmune dysfunction are the major clinical signs of APECED. We report on a 21-year-old female APECED patient with two inactivating mutations in the AIRE gene. Read More

    Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK/NF-κB/TNF-α and TGF-β1/MAPK/Fibronectin pathways.
    Am J Physiol Renal Physiol 2017 May 31:ajprenal.00393.2016. Epub 2017 May 31.
    All India Institute of Medical Sciences
    Diabetic nephropathy (DN), a microvascular complication of diabetes, has emerged as an important health problem worldwide. There is strong evidence to suggest that oxidative stress, inflammation, and fibrosis play a pivotal role in the progression of DN. Apigenin has been shown to possess antioxidant, anti-inflammatory, anti-apoptotic, anti-fibrotic, as well as anti-diabetic properties. Read More

    Recurrence of frozen shoulder after manipulation under anaesthetic (MUA): the results of repeating the MUA.
    Bone Joint J 2017 Jun;99-B(6):812-817
    University of Bristol, Senate House, Tyndall Avenue, Bristol BS8 1TH, UK.
    Aims: Manipulation under anaesthetic (MUA) is a recognised form of treatment for patients with a frozen shoulder. However, not all patients benefit. Some have persistent or recurrent symptoms. Read More

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