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    Screening for non-alcoholic fatty liver disease in children and adolescents with type 1 diabetes mellitus: a cross-sectional analysis.
    Eur J Pediatr 2017 Feb 17. Epub 2017 Feb 17.
    Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Moorenstr. 5, 40225, Duesseldorf, Germany.
    The liver is intensely involved in glucose metabolism and is thereby closely related to diabetes pathophysiology. Adult patients with type 1 diabetes mellitus (DM) are at an increased risk for non-alcoholic fatty liver disease (NAFLD). Here, we studied the prevalence of NAFLD in a cohort of children and adolescents with type 1 DM in a tertiary care paediatric diabetes centre in Germany. Read More

    Hemolytic uremic syndrome complicated by Clostridium septicum bacteremia and new-onset type 1 diabetes mellitus. Report of a case
.
    Clin Nephrol 2017 Feb 17. Epub 2017 Feb 17.
    We report the unusual case of a 5-year-old male hospitalized for management of diabetic ketoacidosis (DKA) and new-onset type 1 diabetes mellitus (T1DM) who developed acute renal injury secondary to hemolytic uremic syndrome (HUS). He was diagnosed with Shiga toxin-producing entero-hemorrhagic Escherichia coli (EHEC) 0157:H7-positive HUS 48 hours after being diagnosed with new-onset T1DM/DKA. His hospital course was complicated by Clostridium septicum sepsis with colonic perforation. Read More

    Early microvascular retinal changes in optical coherence tomography angiography in patients with type 1 diabetes mellitus.
    Acta Ophthalmol 2017 Feb 16. Epub 2017 Feb 16.
    Fondazione G.B.Bietti-IRCCS, Rome, Italy.
    Purpose: Diabetic retinopathy (DR) can lead to significant vision loss and blindness and has a particularly high prevalence in patients with type 1 diabetes (DM1). In this study, we investigate quantitative differences in optical coherence tomography angiography (OCTA) data between DM1 patients with no or mild signs of retinopathy and non-diabetic subjects.

    Methods: Optical coherence tomography angiography (OCTA) imaging was performed on DM1 patients with no or mild nonproliferative diabetic retinopathy and healthy, age-matched controls. Read More

    Evaluating the effectiveness of peer-based intervention in managing type I diabetes mellitus among children and adolescents: A systematic review.
    Med J Islam Repub Iran 2016 19;30:442. Epub 2016 Nov 19.
    PhD, Professor of Clinical Epidemiology, Endocrine Research Center, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran.
    Background: Type 1 diabetes is one of the chronic metabolic disorders among children and adolescents. Peers are also important units in diabetes management through adolescence. This study aimed to evaluate the effectiveness of peer-based intervention in managing type 1 diabetes mellitus among children and adolescents. Read More

    Acute Hyperglycemia Associated with Psychotic Symptoms in a Patient with Type 1 Diabetes Mellitus: A Case Report.
    Innov Clin Neurosci 2016 Nov-Dec;13(11-12):25-27. Epub 2016 Dec 1.
    All from the Department of Psychiatry at the Postgraduate Institute of Medical Education and Research in Chandigarh, India.
    Although psychiatric manifestations in the form of delirium, confusional states, and psychosis have been commonly reported in relation to hypoglycemia, association of hyperglycemia with psychiatric manifestations has been less commonly reported. In this case report, we present the case of a 36-year-old woman suffering from Type 1 diabetes mellitus who developed recurrent episodes of psychosis following poor adherence to her insulin therapy, leading to significantly high levels of blood glucose. Adequate control of blood glucose levels by improving the adherence with insulin led to lack of recurrence of psychosis. Read More

    A Systematic Review and Meta-Analysis of Executive Function Performance in Type 1 Diabetes Mellitus.
    Psychosom Med 2017 Feb 16. Epub 2017 Feb 16.
    1Queensland University of Technology School of Psychology and Counselling; Institute of Health and Biomedical Innovation.
    Objective: To examine the current evidence for executive function (EF) performance differences between groups with Type 1 diabetes mellitus (T1DM) and non-diabetic control groups during adolescence and early adulthood, and to explore the relationships between EF and diabetes-related risk factors.

    Methods: A systematic review of the literature examining EF performance in groups with T1DM was conducted according to the PRISMA guidelines. Electronic database searches for published and unpublished literature yielded a final set of 26 articles after application of inclusion and exclusion criteria. Read More

    Is Diabetes Associated with Lower Vitamin C Status in Pregnant Women? A Prospective Study.
    Int J Vitam Nutr Res 2017 Feb 16:1-5. Epub 2017 Feb 16.
    3 Faculty of Health and Medical Sciences, University of Copenhagen.
    Few studies have examined how vitamin C status is affected in diabetic pregnancy and no comparison between normal and diabetic pregnancies has been found. This study evaluated vitamin C status prospectively during pregnancy in women with type 1 diabetes mellitus (n=76), in non-diabetic women (n=60), and in their respective neonates. Vitamin C was lower in diabetic women throughout all trimesters compared to controls (p<0. Read More

    Attitude, complications, ability of fasting and glycemic control in fasting Ramadan by children and adolescents with type 1 diabetes mellitus.
    Diabetes Res Clin Pract 2017 Feb 1;126:10-15. Epub 2017 Feb 1.
    Institute of Public Health, Emirates University, Al Ain, United Arab Emirates.
    Objectives: Sick individuals and children are exempted from fasting Ramadan. Fasting by type 1 diabetes patients might predispose to acute complications. There are no guidelines on fasting safety or its impact on diabetes control in children and adolescents. Read More

    A Review of the Clinical Efficacy and Safety of Insulin Degludec and Glargine 300 U/mL in the Treatment of Diabetes Mellitus.
    Clin Ther 2017 Feb 7. Epub 2017 Feb 7.
    Section of Endocrinology and Metabolism, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:
    Purpose: The treatment of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) using insulin is not ideal at this time. Despite advances made with basal insulin analogues, many individuals achieve less than optimal glycemic control or are at risk for hypoglycemia. Currently available basal insulin analogues do not deliver steady, peakless, continuous insulin for >24 hours and are associated with adverse events, including hypoglycemia. Read More

    Biphasic effect of alpha-linolenic acid on glucose-induced dysmorphogenesis and lipoperoxidation in whole rat embryo in culture.
    Biochem Biophys Res Commun 2017 Feb 6. Epub 2017 Feb 6.
    Laboratory of Metabolism of Diabetes Mellitus, Morphology and Function Unit, Mexico. Electronic address:
    Type 1 diabetes mellitus complicated with pregnancy, know as diabetic embryopathy, is the cause of neonatal malformations and low for gestational age neonates. With the use of the whole-embryo culture system, it has been demonstrated that high glucose causes embryo dysmorphogenesis, and that oxidative stress appears to be the main mechanism. In recent years, beneficial effect of omega-3 fatty acids has been demonstrated in various diabetic models, and in diabetic complications. Read More

    Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus.
    Mol Neurobiol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Endocrinology, The Second Hospital of Hebei Medical University, No.215, Peace West Road, Shijiazhuang, 050000, Hebei Province, People's Republic of China.
    This study aimed to explore the effects of transient receptor potential melastatin 7 (TRPM7)/microRNA-34a (miR-34a) gene silencing on spatial cognitive function and hippocampal neurogenesis in mice with type 1 diabetes mellitus (T1DM). BALB/c mice were chosen to establish T1DM models and divided into five groups respectively: the negative control (NC), T1DM, T1DM + si-TRPM7, T1DM + si-miR-34a, and T1DM + si-TRPM7 + si-miR-34a groups. Morris water maze (MWM) test was adopted to observe behavioral alterations in mice. Read More

    Childhood cancer, type 1 diabetes and other immune diseases: healthcare visits in the year before diagnosis in Taiwan.
    Arch Dis Child 2017 Feb 8. Epub 2017 Feb 8.
    Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
    Background: Children with cancer, type 1 diabetes and other immune diseases often present initially with non-specific problems. It is unknown how long children with these conditions seek medical help before a diagnosis is reached.

    Methods: During the period 2002 to 2013, 7238 children aged 2-15 years diagnosed with cancer at seven sites, type 1 diabetes, and three other immune diseases were registered in the Taiwan National Health Insurance Catastrophic Illness Database. Read More

    The diabetes management and daily functioning burden of non-severe hypoglycaemia in Japanese people treated with insulin.
    J Diabetes Investig 2017 Feb 8. Epub 2017 Feb 8.
    The Brod Group, 219 Julia Ave, Mill Valley, CA, 94941, USA.
    Aims: This study investigated the impact of non-severe hypoglycaemic events (NSHE) on patients' diabetes management, daily functioning and well-being.

    Methods: A survey assessing the impact of NSHEs was completed by insulin-treated Japanese people with diabetes, aged ≥20 years with self-reported diabetes, who had experienced at least one NSHE in the last 3 months. Survey questions captured reasons for and length of the event, and impacts on diabetes management, daily functioning, sleep and well-being. Read More

    Predictors of Type 1 Diabetes Mellitus Outcomes in Young Adults after Transition from Pediatric Care.
    J Diabetes 2017 Feb 8. Epub 2017 Feb 8.
    Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
    Background: Type 1 diabetes is a common chronic disease. Poor health outcomes are often noted after transfer to adult health care. It is important to determine the predictors of such outcomes to decrease the morbidity and mortality. Read More

    De novo thrombotic microangiopathy following simultaneous pancreas and kidney transplantation managed with eculizumab.
    Nephrology (Carlton) 2017 Feb;22 Suppl 1:23-27
    Department of Nephrology, Monash Health, Melbourne, Victoria, Australia.
    Thrombotic microangiopathy (TMA) is a well-recognised complication following transplantation, often due to an underlying genetic predisposition, medications or rejection. The use of eculizumab in these settings has been previously described, but its role still remains to be clarified. A 45-year-old man, with a history of type 1 diabetes mellitus and subsequent end-stage kidney failure, presented for a simultaneous pancreas-kidney transplant. Read More

    Faster-acting insulin aspart provides faster onset and greater early exposure vs insulin aspart in children and adolescents with type 1 diabetes mellitus.
    Pediatr Diabetes 2017 Feb 6. Epub 2017 Feb 6.
    Clinical Pharmacology, Novo Nordisk A/S, Søborg, Denmark.
    Background: Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide). In adults, faster aspart provides faster onset and greater early exposure and action vs IAsp.

    Aim: This randomized, double-blind, 2-period crossover trial investigated the pharmacological properties of faster aspart vs IAsp in 12 children (6-11 years), 13 adolescents (12-17 years), and 15 adults (18-64 years) with type 1 diabetes mellitus. Read More

    Validity of Actigraphy in Measurement of Sleep in Young Adults with Type 1 Diabetes.
    J Clin Sleep Med 2017 Jan 31. Epub 2017 Jan 31.
    Study Objectives: Accurate objective measurement of sleep, an important health behavior, is needed. Individuals with type 1 diabetes mellitus (T1DM) have altered sleep architecture and reduced sleep quality in comparison with healthy controls. The aim of this investigation was to compare a commonly used actigraphy device, Actiwatch2, with polysomnography (PSG)-based measures of sleep in young adults with T1DM, and to determine which Actiwatch2 threshold setting provides the best correspondence. Read More

    Achieving effective glycaemic control using an insulin micro-pump.
    Br J Community Nurs 2017 Feb;22(2):66-76
    Diabetes Specialist Nurse, Diabetes Centre, Derriford Hospital, Plymouth.
    For those with type 1 diabetes mellitus (T1DM), a deranged blood glucose level can cause hypo/hyperglycaemic episodes and in the long term contribute to microvascular disease. Such outcomes can effect concordance with insulin management regimens and affect the patient's quality of life. A variety of insulin delivery methods are available, including continuous subcutaneous insulin infusion (CSII) via either a tethered or patch pump. Read More

    Maternal Type 1 diabetes activates stress response in early placenta.
    Placenta 2017 Feb 16;50:110-116. Epub 2017 Jan 16.
    Department of Obstetrics and Gynecology, Medical University of Graz, Austria. Electronic address:
    Introduction: Human pregnancy and in particular the first trimester, is a period highly susceptible towards adverse insults such as oxidative stress, which may lead to inadequate embryonic and feto-placental development. Diabetes mellitus is associated with increased oxidative stress caused by hyperglycemia, reactive oxygen species (ROS) production and inflammatory signals. In pregnancy, diabetes elevates the risk for early pregnancy loss, preeclampsia and fetal growth restriction, pathologies that origin from early placental maldevelopment. Read More

    Health-related quality of life and utility values associated to hypoglycemia in patients with type 1 diabetes mellitus treated in the Brazilian Public Health System: a multicenter study.
    Diabetol Metab Syndr 2017 28;9. Epub 2017 Jan 28.
    grid.419171.bInstituto Nacional de Cardiologia-INC, Rio de Janeiro, Brazil.
    Background: Hypoglycemia is a critical and limiting factor of a good metabolic control and can adversely affect the quality of life of diabetic patients. The aim of the study was to evaluate the health-related quality of life and calculate utilities values associated with hypoglycemia in patients with type 1 diabetes mellitus (T1DM).

    Methods: A multicenter, cross-sectional and observational study with T1DM patients from reference centers of the Brazilian public health system was conducted in three cities. Read More

    Effects of Canarium odontophyllum leaves on plasma glucose and T lymphocyte population in streptozotocin-induced diabetic rats.
    Saudi J Biol Sci 2017 Feb 9;24(2):320-323. Epub 2015 Oct 9.
    School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Malaysia.
    Type 1 diabetes mellitus is a chronic disease characterized by lack of insulin production. Immune mechanisms are implicated in the pathogenesis of Type 1 diabetes. Canarium odontophyllum (CO) fruits and leaves have been shown to possess high antioxidant activity. Read More

    En-Bloc Transplant of the Liver, Kidney and Pancreas: Experience from a Latin American Transplant Center.
    Am J Case Rep 2017 Feb 2;18:114-118. Epub 2017 Feb 2.
    Abdominal Transplantation Surgery, Transplantation Unit, Centre for Clinical Research, Fundación Valle de Lili, Centre for Research on Advanced Surgery and Transplants (CICAT), Universidad Icesi, Cali, Valle del Cauca, Colombia.
    BACKGROUND En-bloc transplantation is a surgical procedure in which multiple organs are transplanted simultaneously. It has some similarities with multi-organ transplantation but offers certain advantages. This report highlights the experience of our interdisciplinary group regarding the treatment and follow-up of patients who received en-bloc transplantation, with the aim of encouraging the development of this surgical technique. Read More

    Hypokalaemia in Sjögren's syndrome: the missing piece.
    Clin Med (Lond) 2017 Feb;17(1):40-42
    National University Health System, Singapore and Yong Loo Lin School of Medicine, National University Singapore, Singapore.
    A 58-year-old Chinese woman with well controlled type 1 diabetes mellitus presented with acute and progressive bilateral lower limb weakness. Investigations revealed severe hypokalaemia (1.3 mmol/L) and hypophosphataemia (<0. Read More

    Pediatric Diabetes Outpatient Center at Rhode Island Hospital: The impact of changing initial diabetes education from inpatient to outpatient.
    R I Med J (2013) 2017 Feb 1;100(2):21-24. Epub 2017 Feb 1.
    Department of Pediatrics, Division of Pediatric Endocrinology at Rhode Island Hospital and Hasbro Children's Hospital/The Warren Alpert Medical School of Brown University, Providence, RI.
    Background: This study compared outcomes and costs for new-onset Type 1 diabetes mellitus (T1DM) patients educated at the outpatient versus inpatient settings.

    Methods/design: Retrospective study examining the following variables: 1) hemoglobin A1c (HbA1c), 2) severe hypoglycemia, 3) admissions for diabetic ketoacidosis (DKA) or ER visits, and 4) healthcare cost.

    Results: 152 patients with new-onset T1DM from September 2007-August 2009. Read More

    Cortisol Levels in Children With Diabetic Ketoacidosis Associated With New-Onset Type 1 Diabetes Mellitus.
    Clin Pediatr (Phila) 2017 Feb;56(2):117-122
    1 Columbia University Medical Center, New York, NY, USA.
    There is little data documenting cortisol levels in children with diabetic ketoacidosis (DKA), despite the fact that untreated adrenal insufficiency (AI) could worsen the outcome of DKA. In this cross-sectional study, we assessed serum cortisol levels in 28 children with DKA and new onset type 1 diabetes mellitus evaluated at our center over a 5-year period. Average duration of diabetes-related symptoms was positively associated with age ( P = . Read More

    The effect of adding metformin to insulin therapy for type 1 diabetes mellitus children: A systematic review and meta-analysis.
    Pediatr Diabetes 2017 Feb 1. Epub 2017 Feb 1.
    Department of Pediatrics, Universidad de Antioquia, Medellin, Colombia.
    We aimed to assess the effectiveness of adding metformin to insulin in type 1 diabetes mellitus (T1DM) children for improving metabolic outcomes. We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) conducted on children age 6 to 19 years who are diagnosed with T1DM, and examined the effect of adding Metformin to standard insulin therapy. We performed literature searches on Ovid Midline, Ovid Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) from the date of inception of the database to February 15, 2016. Read More

    Influence of health locus of control and fear of hypoglycaemia on glycaemic control and treatment satisfaction in people with Type 1 diabetes on insulin pump therapy.
    Diabet Med 2017 Feb 1. Epub 2017 Feb 1.
    Division of Metabolic Diseases, Department of Medicine, University of Padova, Padova.
    Aim: To assess the influence of health locus of control and fear of hypoglycaemia on metabolic control and treatment satisfaction in people with Type 1 diabetes mellitus on continuous subcutaneous insulin infusion.

    Methods: People with Type 1 diabetes on continuous subcutaneous insulin infusion for at least 1 year, sub-classified as an 'acceptable glucose control' group [HbA1c ≤58 mmol/mol (7.5%)] and a 'suboptimum glucose control' group [HbA1c >58 mmol/mol (7. Read More

    The Effect of Aerobic Exercise Training on Plasma Apelin Levels and Pain Threshold in T1DM Rats.
    Iran Red Crescent Med J 2016 Sep 11;18(9):e31737. Epub 2016 May 11.
    Exercise Physiology Department, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamadan, IR Iran.
    Background: Diabetes mellitus (types 1 and 2) leads to secondary complications such as neuropathy, which reduce a patient's quality of life. Apelin and its receptor, APJ, have been shown to have antinociceptive effects and to decrease blood glucose levels.

    Objectives: The present experimental study was conducted in Iran and investigated the role of apelin, which is used to manage type 1 diabetes mellitus, during exercise training. Read More

    Comment on Butwicka et al. Psychiatric Disorders and Health-Related Quality of Life in Children With Type 1 Diabetes Mellitus.
    Psychosomatics 2016 Nov 17. Epub 2016 Nov 17.
    Department of Medical and Clinical Psychology, Center of Research on Psychological and Somatic disorders (CoRPS), Tilburg University, Tilburg, The Netherlands; Department of Psychology, South Danish University, Odense, Denmark.

    [Oral antidiabetic drugs in treatment of type 1 diabetes mellitus].
    Vnitr Lek 2016 ;62(12):998-1003
    Review article summarizes current knowledge of the use of oral antidiabetics (approved for treatment of type 2 diabetes) in type 1 diabetic patients. Following drugs were tested: metformin, gliptines, analogues of GLP-1, glitazones, inhibitors of α-glukozidase and gliflozines. The latter seem to be the most perspective ones, however, more studies are warranted for definitive confirmation of their efficacy and safety. Read More

    Complementary therapy of traditional Chinese medicine for blood sugar control in a patient with type 1 diabetes.
    Complement Ther Med 2017 Feb 13;30:10-13. Epub 2016 Sep 13.
    Department of Traditional Chinese Medicine, St. Joseph Hospital, Kaohsiung, Taiwan; School of Chinese Medicine of Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan. Electronic address:
    Objective: Using a case study to discuss the effects of traditional Chinese medicine (TCM) treatments on Type 1 diabetes mellitus.

    Clinical Features: A 4-year-old girl with sudden polyuria and nocturia (fasting plasma glucose level: 270mg/dL) was diagnosed with type 1 diabetes. Although multiple daily insulin injections were applied, her plasma glucose levels were still unstable. Read More

    An Expert Opinion on Advanced Insulin Pump Use in Youth with Type 1 Diabetes.
    Diabetes Technol Ther 2017 Jan 30. Epub 2017 Jan 30.
    4 Lilly USA, LLC, Lilly Corporate Center , US Medical Affairs, Indianapolis, Indiana.
    Among children and adolescents with type 1 diabetes mellitus, the use of insulin pump therapy has increased since its introduction in the early 1980s. Optimal management of type 1 diabetes mellitus depends on sufficient understanding by patients, their families, and healthcare providers on how to use pump technology. The goal for the use of insulin pump therapy should be to advance proficiency over time from the basics taught at the initiation of pump therapy to utilizing advanced settings to obtain optimal glycemic control. Read More

    Production of high-quality islets from goettingen minipigs: Choice of organ preservation solution, donor pool, and optimal cold ischemia time.
    Xenotransplantation 2017 Jan 28. Epub 2017 Jan 28.
    Department of Visceral-, Thoracic- and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
    Background: The transplantation of porcine islets into man might soon become reality for patients with type 1 diabetes mellitus. Therefore, porcine islets of high quality and quantity, and a scalable isolation process with strict quality control will be an unconditional prerequisite to enable the best possible transplantation graft. In this study, we provide a comparative study evaluating islet isolation outcome and in vitro survival based upon donor age, organ preservation solution (OPS), and cold ischemia time (CIT). Read More

    Pregnancy and neonatal outcomes in women with type 1 diabetes mellitus.
    Bratisl Lek Listy 2017 ;118(1):56-60
    Aim: The aim of study was to compare some perinatal outcomes in mothers with type 1 diabetes mellitus (T1DM).

    Material And Methods: All patients with T1DM delivered at the 1st Department of Obstetrics and Gynaecology of Faculty of Medicine, Comenius University in Bratislava from January 1st 2009 to December 31th 2015 were included to the study.

    Results: Out of 118 diabetic mothers, 46. Read More

    Higher Sensitivity and Earlier Identification of Celiac Disease Autoimmunity by a Nonradioactive Assay for Transglutaminase Autoantibodies.
    J Immunol Res 2016 26;2016:2904563. Epub 2016 Dec 26.
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA.
    Higher sensitive transglutaminase autoantibody (TGA) assay will detect the onset of celiac disease (CD) autoimmunity earlier. In developing a nonradioactive assay for TGA, we utilized electrochemiluminescence (ECL) technology and compared it to a high-performance radioimmunoassay (RIA) currently being used to screen patients with type 1 diabetes (T1D) and genetically at-risk individuals for CD. We selected 183 T1D patients with 60 patients having received biopsy and analyzed 396 sequential samples from 73 young children longitudinally followed up with TGA seroconversion, with 27 undergoing biopsy. Read More

    Salivary glucose in monitoring glycaemia in patients with type 1 diabetes mellitus: a systematic review.
    J Diabetes Metab Disord 2017 21;16. Epub 2017 Jan 21.
    0000 0000 8946 5787grid.411729.8Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, 57000 Malaysia.
    Background: Incidence of type 1 diabetes mellitus is increasing worldwide. Monitoring glycaemia is essential for control of diabetes mellitus. Conventional blood-based measurement of glucose requires venepuncture or needle prick, which is not free from pain and risk of infection. Read More

    High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1.
    Dis Markers 2016 29;2016:4685976. Epub 2016 Dec 29.
    Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Gdańsk, Poland.
    The objective of the research was to investigate serum levels of interleukin-12 (IL12) in relation to percentage of yeast-like fungi colonies residing in the gastrointestinal tract in children and adolescents with type 1 diabetes mellitus (T1DM). The study involved 83 children and adolescents, including 53 T1DM patients and 30 healthy control subjects. In the studied population biochemical tests were performed and yeast-like fungi were identified in the faeces. Read More

    Traditional Cardiovascular Risk Factors in Adolescents with Type 1 Diabetes Mellitus.
    Curr Diabetes Rev 2017 Jan 23. Epub 2017 Jan 23.
    University of Sydney and the Children's Hospital at Westmead, Australia.
    Cardiovascular disease as a result of macrovascular changes is the leading cause of mortality in patients with type 1 diabetes (T1DM). While CVD complications are seen predominantly in adulthood, the atherosclerotic process begins in childhood and is accelerated in patients with T1DM. This review focuses on the epidemiology of traditional CVD risk factors in adolescents with T1DM, its association with markers of CVD and an overview of studies looking into each individual risk factor. Read More

    Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections: The GOLD Randomized Clinical Trial.
    JAMA 2017 01;317(4):379-387
    Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden.
    Importance: The majority of individuals with type 1 diabetes do not meet recommended glycemic targets.

    Objective: To evaluate the effects of continuous glucose monitoring in adults with type 1 diabetes treated with multiple daily insulin injections.

    Design, Setting, And Participants: Open-label crossover randomized clinical trial conducted in 15 diabetes outpatient clinics in Sweden between February 24, 2014, and June 1, 2016 that included 161 individuals with type 1 diabetes and hemoglobin A1c (HbA1c) of at least 7. Read More

    Effect of Continuous Glucose Monitoring on Glycemic Control in Adults With Type 1 Diabetes Using Insulin Injections: The DIAMOND Randomized Clinical Trial.
    JAMA 2017 01;317(4):371-378
    Dexcom Inc, San Diego, California.
    Importance: Previous clinical trials showing the benefit of continuous glucose monitoring (CGM) in the management of type 1 diabetes predominantly have included adults using insulin pumps, even though the majority of adults with type 1 diabetes administer insulin by injection.

    Objective: To determine the effectiveness of CGM in adults with type 1 diabetes treated with insulin injections.

    Design, Setting, And Participants: Randomized clinical trial conducted between October 2014 and May 2016 at 24 endocrinology practices in the United States that included 158 adults with type 1 diabetes who were using multiple daily insulin injections and had hemoglobin A1c (HbA1c) levels of 7. Read More

    CDE Perspectives of Providing New-Onset Type 1 Diabetes Education Using Formal Vignettes and Simulation.
    Diabetes Educ 2017 Feb 15;43(1):97-104. Epub 2016 Nov 15.
    New York University Rory Meyers College of Nursing, New York, New York (Ms Ramchandani, Dr Sullivan-Bolyai).
    Purpose The purpose of this article is to describe the 4 Parent Education Through Simulation-Diabetes (PETS-D) nurse certified diabetes educators' (CDEs) perspectives of teaching parents of children with newly diagnosed type 1 diabetes mellitus (T1DM) early diabetes management skills using formal vignettes and a human patient simulator/human patient simulation (HPS) to augment/enhance the teaching-learning process. Methods A qualitative descriptive approach was used. Four CDEs were interviewed by phone about their teaching experiences. Read More

    Hypoglycemia-Associated EEG Changes Following Antecedent Hypoglycemia in Type 1 Diabetes Mellitus.
    Diabetes Technol Ther 2017 Feb;19(2):85-90
    1 Faculty of Health, University of Southern Denmark , Odense, Denmark .
    Background: Recurrent hypoglycemia has been shown to blunt hypoglycemia symptom scores and counterregulatory hormonal responses during subsequent hypoglycemia. We therefore studied whether hypoglycemia-associated electroencephalogram (EEG) changes are affected by an antecedent episode of hypoglycemia.

    Methods: Twenty-four patients with type 1 diabetes mellitus (10 with normal hypoglycemia awareness, 14 with hypoglycemia unawareness) were studied on 2 consecutive days by hyperinsulinemic glucose clamp at hypoglycemia (2. Read More

    Blood pressure regulation determined by ambulatory blood pressure profiles in children and adolescents with type 1 diabetes mellitus: Impact on diabetic complications.
    Pediatr Diabetes 2017 Jan 24. Epub 2017 Jan 24.
    Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.
    Background: The combination of high blood pressure and hyperglycemia contributes to the development of diabetic complications. Ambulatory monitoring of blood pressure (ABPM) is seen as standard to assess blood pressure (BP) regulation.

    Objective: We evaluated 24-hour BP regulation in 3529 children with type 1 diabetes, representing 5. Read More

    High HbA1c at onset cannot be used as a predictor for future metabolic control for the individual child with type 1 diabetes mellitus.
    Pediatr Diabetes 2017 Jan 24. Epub 2017 Jan 24.
    Department of Clinical and Experimental Medicine, Division of Paediatrics and Diabetes Research Centre, Linköping University Hospital, Linköping, Sweden.
    Background: To study how metabolic control at onset of type 1 diabetes correlates to metabolic control and clinical parameters during childhood until transition from pediatric care to adult diabetes care.

    Materials And Methods: Data at onset, three months, one, three, and five years after diagnosis and at transition, on HbA1c and clinical parameters, on 8084 patients in the Swedish pediatric quality registry, SWEDIABKIDS, were used. Of these patients, 26% had been referred to adult diabetes care by 2014. Read More

    Inverse relationship between type 1 diabetes mellitus and migraine. Data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008.
    Cephalalgia 2017 Jan 1:333102417690488. Epub 2017 Jan 1.
    1 Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
    Aims The aim of this cross-sectional population-based study was to investigate the associations between migraine and type 1 and type 2 diabetes mellitus (DM). Methods We used data from the second (1995-1997) and third survey (2006-2008) in the Nord-Trøndelag Health Study. Analyses were made for the 26,121 participants (30-97 years of age, median 58. Read More

    Social anxiety levels and associated factors among adolescents with type 1 diabetes compared with healthy peers.
    J Spec Pediatr Nurs 2017 Jan;22(1)
    Nursing Department, Gazi University Health Sciences Faculty, Ankara, Turkey.
    Purpose: The purpose of this study was to examine adolescent social anxiety and related factors among youth aged 12-15 years with type 1 diabetes mellitus (T1DM) compared to healthy peers.

    Design And Methods: The study used a descriptive correlational design. The data were collected with The Social Anxiety Scale for Adolescents (SAS-A) and a youth descriptive information form. Read More

    Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus.
    Pediatr Diabetes 2017 Jan 23. Epub 2017 Jan 23.
    Department of Cell Biology and Physiology, Washington University Medical School, St. Louis, Missouri.
    Background: Patients with early onset diabetes because of defects in glucose-stimulated insulin secretion (GSIS) may respond better to sulfonylureas than insulin treatment. Such patients include those with monogenic disorders, who can be differentiated from autoimmune type 1 diabetes mellitus (T1DM) by genetic testing. Genetic testing is expensive and unknown defects in GSIS would not be diagnosed. Read More

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