75,403 results match your criteria Diabetes Mellitus Type 1


Retinal Microvascular Abnormalities in Children with Type 1 Diabetes Mellitus Without Visual Impairment or Diabetic Retinopathy.

Invest Ophthalmol Vis Sci 2019 Mar;60(4):990-998

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: To study the characteristics and associated factors of retinal microvascular abnormalities in children with type 1 diabetes mellitus (T1DM) without visual impairment and diabetic retinopathy (DR).

Methods: Case-control hospital-based study including children with or without DM. Optical coherence tomography angiography (OCTA; CIRRUS HD-OCT model 5000) was used to scan 6 × 6 mm square area of posterior retina and optic disc. Read More

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http://dx.doi.org/10.1167/iovs.18-25499DOI Listing

Platelet Indices Alterations in Children With Type 1 Diabetes Mellitus.

J Pediatr Hematol Oncol 2019 Mar 15. Epub 2019 Mar 15.

Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht.

Platelet (PLT) hyperactivity is a key factor which contributes to cardiovascular complications in patients with type 2 diabetes mellitus even in preclinical stages of disease. To the best of our knowledge, there is limited researches in this regard among patients with type 1 diabetes. The aim of this study was to evaluate hematologic indices indicating PLT activity in children with type 1 diabetes. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001454DOI Listing

Performance-based and questionnaire measures of executive function in adolescents with type 1 diabetes.

J Behav Med 2019 Mar 16. Epub 2019 Mar 16.

Department of Pediatrics, Vanderbilt University Medical Center, 2525 West End Ave., Suite 1200, Nashville, TN, 37232, USA.

The purpose of the current study was to examine executive function (EF) in adolescents with type 1 diabetes using both performance-based and questionnaire measures in relation to diabetes indicators. Adolescents age 13-17 completed performance-based measures of EF and measures of adherence. Adolescents' parents reported on adolescents' EF and adherence. Read More

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http://dx.doi.org/10.1007/s10865-019-00027-2DOI Listing

Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach.

J Clin Med 2019 Mar 12;8(3). Epub 2019 Mar 12.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea.

The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. This work examined their validity to discover false positive results under Bayesian methods. Read More

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https://www.mdpi.com/2077-0383/8/3/347
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http://dx.doi.org/10.3390/jcm8030347DOI Listing
March 2019
2 Reads

Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient.

Endocrinol Diabetes Metab Case Rep 2019 Mar 14;2019. Epub 2019 Mar 14.

Wolfson Diabetes Centre, Addenbrooke's Hospital Cambridge, Cambridge, UK.

Necrobiosis lipoidica diabeticorum (NLD) is a chronic granulomatous dermatitis generally involving the anterior aspect of the shin, that arises in 0.3-1.2% of patients with diabetes mellitus (1). Read More

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http://dx.doi.org/10.1530/EDM-19-0007DOI Listing
March 2019
2 Reads

[New modes of insulin delivery and new modes of monitoring of type 1 diabetes mellitus].

Authors:
Éric Renard

Rev Prat 2018 Jun;68(6):620-627

Département d'endocrinologie, diabète, nutrition, CHU de Montpellier, centre d'investigation clinique Inserm CIC 1411, institut de génomique fonctionnelle, UMR CNRS 5203, Inserm U1191, université de Montpellier, Montpellier, France.

New modes of insulin delivery and new modes of monitoring of type 1 diabetes mellitus. Insulin therapy in type 1 diabetes aims at keeping blood glucose level in a near-normal range. Basal-bolus regimen using multiple daily injections of insulin analogues or, with higher flexibility and precision, an insulin pump fulfils the coverage of basal needs and those related to food intakes. Read More

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June 2018
1 Read

Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin.

Stem Cell Res Ther 2019 Mar 12;10(1):85. Epub 2019 Mar 12.

Laboratory of Fundamental and Applied Bioenergetics (LBFA), INSERM U 1055 and SFR Environmental and Systems Biology (BEeSy), University Grenoble Alpes, Grenoble, BP 53, F-38041, Grenoble Cedex, France.

Background: Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation. In other tissues, co-transplantation with mesenchymal stem cells has been shown to reduce damage by improving anti-inflammatory and anti-oxidant defences. Therefore, we probed the protection afforded by bone marrow mesenchymal stem cells to islets under pro-inflammatory cytokine stress. Read More

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http://dx.doi.org/10.1186/s13287-019-1190-4DOI Listing

Myocardial dysfunction in relation to serum thiamine levels in children with diabetic ketoacidosis.

J Pediatr Endocrinol Metab 2019 Mar 13. Epub 2019 Mar 13.

Clinical Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Background Thiamine deficiency is commonly reported in patients with diabetes especially during diabetic ketoacidosis (DKA) that could attribute to myocardial dysfunction in those patients. However, there is limited data regarding its relation to myocardial function among those patients. This study aimed to explore the association between myocardial function and serum thiamine levels in children with type 1 diabetes mellitus (DM). Read More

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http://dx.doi.org/10.1515/jpem-2018-0320DOI Listing
March 2019
1 Read

Exposure to environmental chemicals and type 1 diabetes: an update.

Authors:
Sarah G Howard

J Epidemiol Community Health 2019 Mar 12. Epub 2019 Mar 12.

Diabetes and Environment Program, Commonweal, Bolinas, CA 94924, USA

This narrative review summarises recently published epidemiological and in vivo experimental studies on exposure to environmental chemicals and their potential role in the development of type 1 diabetes mellitus (T1DM). These studies focus on a variety of environmental chemical exposures, including to air pollution, arsenic, some persistent organic pollutants, pesticides, bisphenol A and phthalates. Of the 15 epidemiological studies identified, 14 include measurements of exposures during childhood, 2 include prenatal exposures and 1 includes adults over age 21. Read More

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http://dx.doi.org/10.1136/jech-2018-210627DOI Listing
March 2019
2 Reads

Prevalence of dyslipidemia and factors affecting dyslipidemia in young adults with type 1 diabetes: evaluation of statin prescribing.

J Pediatr Endocrinol Metab 2019 Mar 12. Epub 2019 Mar 12.

Department of Adult Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Background There is limited information about cardiovascular complications among young adults (YA) with type 1 diabetes mellitus (T1DM) who are transitioning from pediatric to adult care. We aimed to study the prevalence and associated factors of dyslipidemia (DLD) and statin treatment in these patients. Methods We recruited 129 YA with T1DM aged 15-25 years. Read More

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http://dx.doi.org/10.1515/jpem-2018-0383DOI Listing
March 2019
1 Read

The reconstructed natural history of type 1 diabetes mellitus.

Nat Rev Endocrinol 2019 Mar 11. Epub 2019 Mar 11.

Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, "Sapienza" University of Rome, Rome, Italy.

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http://www.nature.com/articles/s41574-019-0192-8
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http://dx.doi.org/10.1038/s41574-019-0192-8DOI Listing
March 2019
2 Reads

Sudden death due to diabetic ketoacidosis following power failure of an insulin pump: Autopsy and pump data.

J Forensic Leg Med 2019 Feb 26;63:34-39. Epub 2019 Feb 26.

Institute of Forensic Medicine, University of Southern Denmark, J.B. Winsløws Vej 17B, 5000, Odense C, Denmark. Electronic address:

Purpose: To report a case in which autopsy findings and data from an insulin pump illustrate the course up to the death of a 31-year-old man with a history of type 1 diabetes mellitus who was found dead in his apartment with his insulin pump disassembled and placed in another room.

Methods: Autopsy findings including histological, toxicological and biochemical examination are presented. Postmortem download of data from the insulin pump gave the history of the pump, which included blood glucose, insulin bolus, carbohydrate intake and the time course in the days to death, and the pump settings were recorded. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1752928X183067
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http://dx.doi.org/10.1016/j.jflm.2019.02.013DOI Listing
February 2019
3 Reads

Insulin-Based Infusion System: Advancing the Development.

J Diabetes Sci Technol 2019 Mar 10:1932296819832876. Epub 2019 Mar 10.

2 Steno Diabetes Center North Jutland, Aalborg, Denmark.

Background:: Deviations in glucose control in critical care have been shown to increase mortality and morbidity. However, optimal glucose control through present technologies has shown to be a challenge. The insulin balanced infusion system (IBIS) is a new and emerging technology. Read More

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http://dx.doi.org/10.1177/1932296819832876DOI Listing
March 2019
1 Read

A case of nivolumab-induced acute-onset type 1 diabetes mellitus in melanoma.

Curr Oncol 2019 Feb 1;26(1):e115-e118. Epub 2019 Feb 1.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan.

Nivolumab, an anti-PD-1 antibody, is now considered an important therapeutic agent in several advanced malignancies. However, immune-related adverse events such as endocrinopathies have been reported with its use. Thyroid disorder and isolated adrenocorticotropic hormone deficiency have frequently been reported as nivolumab-induced immune-related adverse events. Read More

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http://dx.doi.org/10.3747/co.26.4130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380632PMC
February 2019
2 Reads

Diabetes mellitus secondary to treatment with immune checkpoint inhibitors.

Curr Oncol 2019 Feb 1;26(1):e111-e114. Epub 2019 Feb 1.

First Department of Clinical Oncology, Theagenio Hospital, Thessaloniki, Greece.

Cancer immunotherapy has been one of the highlights in the advancement of cancer care. Certain immune checkpoint inhibitors bind to PD-1 on T cells and mediate an antitumour immune response. Given that immune checkpoint inhibitors are becoming part of standard care, a new class of adverse events-immune-related adverse events-has emerged. Read More

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http://dx.doi.org/10.3747/co.26.4151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380640PMC
February 2019
2 Reads

Relationship between glucose control, glycemic variability, and oxidative stress in children with type 1 diabetes.

Endocrinol Diabetes Nutr 2019 Mar 7. Epub 2019 Mar 7.

Servicio de Endocrinología y Nutrición, Hospital Regional de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Plaza del Hospital Civil sn, 29009 Málaga, Spain; CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III, C/Sinesio Delgado 4, 28029 Madrid, Spain.

Introduction: Few studies assessing the relationship between oxidative stress and glycemic variability in children with type 1 diabetes mellitus (T1DM) are available, and most of them reported no significant results.

Objective: To assess the relationship between glucose control, glycemic variability, and oxidative stress as measured by urinary excretion of 8-iso-prostanglandin F2-alpha (8-iso-PGF2α) in children with T1DM.

Materials And Methods: A cross-sectional study including 25 children with T1DM. Read More

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http://dx.doi.org/10.1016/j.endinu.2018.12.010DOI Listing

Beneficial Effects of Hydroalcoholic Extract of Saffron in Alleviating Experimental Autoimmune Diabetes in C57bl/6 Mice.

Iran J Allergy Asthma Immunol 2019 Feb;18(1):38-47

Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Streptozocin (STZ) is a strong alkalizing agent which is capable of destroying the beta cells of the pancreatic islets. Multiple low doses (40 mg/kg, intraperitoneally for 5 consecutive days) prescription of STZ to mice can lead to the T cell-dependent immune response and induction of autoimmune diabetes (AD) with complete similarity to the human type 1 diabetes (T1D). This study has evaluated the effects of hydroalcoholic extract of saffron on the clinical and immunological profile of experimental autoimmune diabetes in C57BL/6 mice. Read More

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February 2019
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Drug delivery systems for diabetes treatment Running title: Delivery systems for insulin.

Curr Pharm Des 2019 Mar 6. Epub 2019 Mar 6.

Institute of nuclear science Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, Belgrade. Serbia.

Background: . Insulin is essential for the treatment of Type 1 diabetes mellitus (T1DM) and necessary in numerous cases of Type 2 diabetes mellitus (T2DM). Prolonged administration of anti-diabetic therapy is necessary for the maintenance of the normal glucose levels and thereby preventing vascular complications. Read More

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http://dx.doi.org/10.2174/1381612825666190306153838DOI Listing
March 2019
1 Read

Undiagnosed coronary artery disease in long-term type 1 diabetes. The Dialong study.

J Diabetes Complications 2019 Jan 31. Epub 2019 Jan 31.

Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway; The Norwegian Diabetics' Center, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Aims: We studied the total prevalence of obstructive coronary artery disease (CAD), undiagnosed CAD and absent CAD in persons with ≥45-year duration of type 1 diabetes (T1D) versus controls, and associations with mean HbA, LDL-cholesterol and blood pressure over 2-3 decades.

Methods: We included 76% (n = 103) of all persons with T1D diagnosed ≤1970 attending a diabetes center and 63 controls without diabetes. We collected 20-30 years of HbA, LDL-cholesterol and blood pressure measurements. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2019.01.006DOI Listing
January 2019
1 Read

Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children.

BMC Pediatr 2019 Mar 7;19(1):71. Epub 2019 Mar 7.

Department of Pediatrics, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat-13110, Jabriya, Kuwait.

Background: The incidence of type 1 diabetes mellitus (T1DM) in Kuwait is amongst the highest in the world. Vitamin D is considered to be involved in immune modulation and its deficiency contribute to autoimmune destruction of insulin producing beta cells in T1DM patients. Vitamin D has been shown to exert its effects via a nuclear vitamin D receptor (VDR) and therefore, VDR gene may be considered a candidate for T1DM susceptibility. Read More

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http://dx.doi.org/10.1186/s12887-019-1448-0DOI Listing

Is our treatment in type 1 diabetes mellitus (insulin therapy models, metabolic control) optimal for preventing cardiovascular autonomic neuropathy?

Endokrynol Pol 2019 Mar 7. Epub 2019 Mar 7.

Katedra i Klinika Chorób Metabolicznych, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, Poland.

Introduction: Long-term poor metabolic control promotes the occurrence of microvascular complications, such cardiovascular autonomic neuropathy and atherogenic hyperlipidaemia, which translates into increased mortality in patients with type 1 diabetes (T1DM).

Aims: To assess the prevalence of cardiovascular autonomic neuropathy (CAN) in patients with T1DM in relation to treatment method (continuous subcutaneous insulin infusion (CSII) versus multiple daily injections using pens (MDI)) and lipid control.

Material And Methods: The study group comprised 93 adults (60 women, 33 men), median age 31, with T1DM being treated in a local clinical centre in 2011-2015. Read More

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http://dx.doi.org/10.5603/EP.a2019.0011DOI Listing
March 2019
1 Read

Impact of Use Frequency of a Mobile Diabetes Management App on Blood Glucose Control: Evaluation Study.

JMIR Mhealth Uhealth 2019 Mar 7;7(3):e11933. Epub 2019 Mar 7.

Institut d'Informatica i Aplicacions, Universitat de Girona, Girona, Spain.

Background: Technology has long been used to carry out self-management as well as to improve adherence to treatment in people with diabetes. However, most technology-based apps do not meet the basic requirements for engaging patients.

Objective: This study aimed to evaluate the effect of use frequency of a diabetes management app on glycemic control. Read More

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http://dx.doi.org/10.2196/11933DOI Listing
March 2019
1 Read

Excessive Sodium Bicarbonate Infusion May Result in Osmotic Demyelination Syndrome During Treatment of Diabetic Ketoacidosis: A Case Report.

Diabetes Ther 2019 Mar 6. Epub 2019 Mar 6.

Division of Critical Care, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.

Introduction: We present a case wherein diabetic ketoacidosis (DKA) was treated with a large amount of sodium bicarbonate and potassium chloride, resulting in the development of osmotic demyelination syndrome (ODS).

Case Presentation: Our patient was a 29-year-old male with a history of post-surgical repair for ventricular septal defect. Upon arrival, the patient's Glasgow Coma Scale (GCS) score was E2M4V3. Read More

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http://dx.doi.org/10.1007/s13300-019-0592-8DOI Listing
March 2019
2 Reads

Exaggerated mechanoreflex in early stage type 1 diabetic rats: Role of Piezo channels.

Am J Physiol Regul Integr Comp Physiol 2019 Mar 6. Epub 2019 Mar 6.

Kinesiology and Health Education, University of Texas at Austin, United States.

Recent findings have shown that muscle contraction evokes an exaggerated pressor response in type 1 diabetes mellitus (T1DM) rats; however, it is not known whether the mechanoreflex, which is commonly stimulated by stretching the Achilles tendon, contributes to this abnormal response. Furthermore, the role of mechano-gated Piezo channels, found on thin fiber afferent endings, in evoking the mechanoreflex in T1DM is also unknown. We therefore examined, in male and female streptozotocin (50 mg/kg) induced T1DM rats (STZ) and healthy controls (CTL), the pressor and cardioaccelerator response to tendon stretch during the early stage of the disease. Read More

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http://dx.doi.org/10.1152/ajpregu.00294.2018DOI Listing

A case of pembrolizumab-induced severe DKA and hypothyroidism in a patient with metastatic melanoma.

Endocrinol Diabetes Metab Case Rep 2019 Mar 5;2019. Epub 2019 Mar 5.

Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland.

Immune checkpoint inhibitors (ICIs) have revolutionised cancer therapy and improved outcomes for patients with advanced disease. Pembrolizumab, a monoclonal antibody that acts as a programmed cell death 1 (PD-1(PDCD1)) inhibitor, has been approved for the treatment of advanced melanoma and other solid tumours. Immune-related adverse events (irAEs) including endocrinopathies have been well described with this and other PD-1 inhibitors. Read More

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https://edm.bioscientifica.com/view/journals/edm/2019/1/EDM1
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http://dx.doi.org/10.1530/EDM-18-0153DOI Listing
March 2019
6 Reads

Hyperglycemic hyperosmolar state in an adolescent with type 1 diabetes mellitus.

Endocrinol Diabetes Metab Case Rep 2019 Mar 5;2019. Epub 2019 Mar 5.

Department of Pediatrics, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.

Hyperglycemic hyperosmolar state (HHS) and diabetic ketoacidosis (DKA) are the most severe acute complications of diabetes mellitus (DM). HHS is characterized by severe hyperglycemia and hyperosmolality without significant ketosis and acidosis. A 14-year-old Japanese boy presented at the emergency room with lethargy, polyuria and polydipsia. Read More

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http://dx.doi.org/10.1530/EDM-18-0131DOI Listing
March 2019
2 Reads

Feasibility and Safety of a Group Physical Activity Program for Youth with Type 1 Diabetes.

Pediatr Diabetes 2019 Mar 4. Epub 2019 Mar 4.

Yale University School of Nursing, West Haven, CT, USA, 06516.

Background/objective: Many adolescents with type 1 diabetes do not achieve 60 minutes of daily moderate to vigorous physical activity (MVPA). Recognizing the importance of peer influence during adolescence, we evaluated the feasibility and safety of a group MVPA intervention for this population.

Subjects: Eighteen adolescents with type 1 diabetes (age 14. Read More

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http://dx.doi.org/10.1111/pedi.12841DOI Listing
March 2019
2 Reads

Patient and disease characteristics of adult patients with type 1 diabetes in Germany: an analysis of the DPV and DIVE databases.

Ther Adv Endocrinol Metab 2019 28;10:2042018819830867. Epub 2019 Feb 28.

Institut für Epidemiologie und medizinische Biometrie, ZIBMT, Universität Ulm, Ulm, Germany Deutsches Zentrum für Diabetesforschung Eingetragener Verein, München-Neuherberg, Germany.

Background: An understanding of the current status of patients with type 1 diabetes mellitus (T1DM) can help to provide appropriate treatment.

Methods: This was a retrospective analysis of the DIabetes Versorgungs-Evaluation (DIVE) and the Diabetes-Patienten-Verlaufsdokumentation (DPV) databases for Germany.

Results: The analysis included 56,250 people with T1DM (54. Read More

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http://dx.doi.org/10.1177/2042018819830867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396055PMC
February 2019
1 Read

Corrigendum: Exposing the Causal Effect of C-Reactive Protein on the Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study.

Front Genet 2019 18;10:85. Epub 2019 Feb 18.

Department of Rehabilitation and Pharmacy, Heilongjiang Province Land Reclamation Headquarters General Hospital, Harbin, China.

[This corrects the article DOI: 10.3389/fgene.2018. Read More

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http://dx.doi.org/10.3389/fgene.2019.00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387998PMC
February 2019
4 Reads

Knowledge and practice of harm-reduction behaviours for alcohol and other illicit substance use in adolescents with type 1 diabetes.

Paediatr Child Health 2019 Feb 7;24(1):e51-e56. Epub 2018 Jun 7.

Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta.

Objective: To survey adolescents with type 1 diabetes mellitus (T1DM) about their knowledge and application of harm-reduction recommendations when they engage in alcohol and other illicit substance use.

Methods: Cross-sectional survey and chart review of adolescents with T1DM aged 13 to 18 years.

Results: One hundred and ninety patients were approached and 164 were included in the analysis. Read More

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http://dx.doi.org/10.1093/pch/pxy075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376295PMC
February 2019

Long term risk of developing type 1 diabetes after HPV vaccination in males and females.

Vaccine 2019 Feb 28. Epub 2019 Feb 28.

Kaiser Permanente Vaccine Study Center, Oakland, CA, United States.

Introduction: Despite minimal evidence, public concerns that the human papillomavirus (HPV) vaccine can cause autoimmune diseases (AD) persist. We evaluated whether HPV vaccine is associated with a long-term increased risk of diabetes mellitus type 1 (DM1).

Methods: This was a retrospective cohort study in which we identified all potential DM1 cases from Kaiser Permanente Northern California (KPNC) members who were between 11 and 26 years old any time after June 2006 through December 2015. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.02.051DOI Listing
February 2019
1 Read

Role of vitamin D and vitamin D receptor gene polymorphisms on residual beta cell function in children with type 1 diabetes mellitus.

Pharmacol Rep 2018 Dec 28;71(2):282-288. Epub 2018 Dec 28.

Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: After the onset of type 1 diabetes mellitus (T1DM), preservation of the residual ß-cell function can help good metabolic control. The aim of this study was to evaluate the effect of vitamin D and its receptor gene polymorphisms on residual ß-cells function.

Methods: One hundred and one children with T1DM (new cases) older than 5 years were selected. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.12.012DOI Listing
December 2018
1 Read

Continuous Subcutaneous Insulin Infusion versus Multiple daily Insulin Injections in Patients with Type 1 Diabetes Mellitus who Fast during Ramadan: A Systematic Review and Meta-analysis.

Diabetes Res Clin Pract 2019 Feb 27. Epub 2019 Feb 27.

Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar; University of Manchester, Institute of Cardiovascular Medicine, Manchester, United Kingdom. Electronic address:

Background: The benefits and risks of continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI) in patients with Type 1 diabetes mellitus (T1DM) who fast during Ramadan are not known.

Methods: Systematic review and meta-analysis of observational studies conducted in PubMed, Embase (Ovid), and the Cochrane Library. Quality of included studies was assessed using the ROBINS-I tool for risk of bias assessment and analyses were performed using RevMan version 5. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.019DOI Listing
February 2019
1 Read

Mobile phone text messaging in improving glycaemic control for patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

Diabetes Res Clin Pract 2019 Feb 26;150:27-37. Epub 2019 Feb 26.

Westmead Hospital, Sydney, Australia; Sydney Medical School, The University of Sydney, NSW, Australia.

Background: Mobile health is the use of mobile technology in developing healthcare, with the aim of reminding and motivating patients to adopt a healthy lifestyle. We conducted a systematic review assessing the effectiveness of text-messaging interventions on HbA1c in patients with Type 2 diabetes mellitus (T2DM).

Methods: Two authors independently searched MEDLINE, Embase, CINAHL, Cochrane Register of Randomized Control Trials and PsychInfo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183134
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http://dx.doi.org/10.1016/j.diabres.2019.02.022DOI Listing
February 2019
1 Read

Clinical pharmacology study of ipragliflozin in Japanese patients with type 1 diabetes mellitus: A phase 2, randomized, placebo-controlled trial.

Diabetes Obes Metab 2019 Mar 1. Epub 2019 Mar 1.

Astellas Pharma Inc, Tokyo, Japan.

Aims: To evaluate the pharmacodynamics, pharmacokinetics, and safety of the novel oral sodium-glucose co-transporter 2 inhibitor, ipragliflozin, in Japanese patients with type 1 diabetes mellitus.

Materials And Methods: We conducted a multicenter, double-blind, placebo-controlled, parallel-group study. Patients were randomized to receive 25, 50, or 100 mg/day ipragliflozin or placebo for 2 weeks. Read More

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http://dx.doi.org/10.1111/dom.13679DOI Listing

Monocytes of newly diagnosed juvenile DM1 patients are prone to differentiate into regulatory IL-10 M2 macrophages.

Immunol Res 2019 Mar 1. Epub 2019 Mar 1.

Department of Medical Immunology, Laboratory of Experimental Immunology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland.

Alternatively activated macrophages (M2) exert anti-inflammatory effects and are crucial for keeping balance between protective and destructive cell-mediated immunity in healing phase of inflammation. Two members of the interferon regulatory factors family, IRF5 and IRF4, are known to promote M1 or M2 phenotype, respectively. Our study aimed to analyse the effectiveness of the M2 differentiation process in vitro (achieved by IL-4 stimulation) and its relationship to the stage of type 1 diabetes mellitus (DM1) in juvenile patients. Read More

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http://dx.doi.org/10.1007/s12026-019-09072-0DOI Listing

The role of autoimmunity in women with type 1 diabetes and adverse pregnancy outcome: A missing link.

Immunobiology 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, the Netherlands; Department of Pathology and Medical Biology, Div. of Medical Biology, University of Groningen, University Medical Center Groningen, the Netherlands. Electronic address:

The incidence of pregnancy complications in women with type 1 Diabetes Mellitus (T1D) is greater than in healthy pregnant women. This has mostly been attributed to hyperglycemia. However, despite the implementation of stricter guidelines regarding glycemic control, pregnancy complications remain more common in women with T1D. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.003DOI Listing
February 2019
1 Read

Can parents' educational level and occupation affect perceived parental support and metabolic control in adolescents with type 1 diabetes?

J Educ Health Promot 2019 29;8:11. Epub 2019 Jan 29.

Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background/aim: Parents have an important role to play in supporting adolescents with type 1 diabetes mellitus (T1DM). Their education and occupation are important factors for the management of this disease. This study aimed to investigate the parental support that Iranian adolescents with T1DM experience and to examine the effect of parents' education and occupation on adolescents' perceived the parental support and metabolic control. Read More

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http://dx.doi.org/10.4103/jehp.jehp_215_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378813PMC
January 2019

The impact of poor glycemic control on lipid profile variables in children with type 1 diabetes mellitus.

J Educ Health Promot 2019 29;8. Epub 2019 Jan 29.

Pediatric Pulmonology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Type 1 diabetes mellitus (T1DM) and its related comorbidities are considered an important health issue. This study aimed to evaluate the impact of glycemic control on lipid profile variables in children with T1DM.

Materials And Methods: This study included 274 children (≤19 years of age) with T1DM who had referred to the outpatient clinics of endocrinology in Emam-Hossein Hospital of Isfahan, Iran. Read More

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http://dx.doi.org/10.4103/jehp.jehp_194_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378828PMC
January 2019
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Associations of renal function with diabetic retinopathy and visual impairment in type 2 diabetes: A multicenter nationwide cross-sectional study.

World J Nephrol 2019 Feb;8(2):33-43

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, United States.

Background: Diabetic retinopathy (DR) separately has been noted as a major public health problem worldwide as well. Currently, many studies have demonstrated an association between diabetic nephropathy and DR in type 1 diabetes mellitus (T1DM) patients, but this association is less strong in T2DM. The evidence for an association between renal function and DR and visual impairment among T2DM patients is limited, particularly in the Asian population. Read More

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http://dx.doi.org/10.5527/wjn.v8.i2.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388308PMC
February 2019
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The emerging role of immunothrombosis in paediatric conditions.

Pediatr Res 2019 Feb 26. Epub 2019 Feb 26.

Specialist Neonatal and Paediatric Surgery Department, Great Ormond Street Hospital for Children, London, UK.

Immunothrombosis is a physiological process based on the release of neutrophil extracellular traps (NETs) to immobilise, contain and kill bacteria. This is an innate immune response in which the local activation of blood coagulation exerts the critical protective function during microbial infection. In recent years, there has been much interest in the adult literature about the key role of immunothrombosis in pathologic states including thrombosis, cancer, sepsis and trauma. Read More

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http://dx.doi.org/10.1038/s41390-019-0343-6DOI Listing
February 2019
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Alterations of Tear Film and Ocular Surface in Children with Type 1 Diabetes Mellitus.

Ocul Immunol Inflamm 2019 Feb 26:1-8. Epub 2019 Feb 26.

d Department of Pediatric Endocrinology , Dr. Sami Ulus Children's Health and Disease Training and Research Hospital , Ankara , Turkey.

Purpose: To investigate whether diabetes mellitus (DM) affects ocular surface of children with well-controlled type 1 DM.

Methods: Sixty-five diabetic patients and 55 age-matched controls enrolled to study. Detailed ocular surface assessment including, ocular surface disease index (OSDI) questionnaire, tear film break-up time (TBUT) analysis, Schirmer test, and conjunctival impression cytologic analysis were performed. Read More

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http://dx.doi.org/10.1080/09273948.2019.1571212DOI Listing
February 2019
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Lead Toxicity due to Use of Traditional Medicines in a Child with Type 1 Diabetes Mellitus.

Indian Pediatr 2019 Jan;56(1):77-78

Endocrinology and Diabetes Unit, Department of Pediatrics, Advanced Pediatrics Center, PGIMER, Chandigarh, India.

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January 2019
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Two cases of diabetes mellitus type 1 after alemtuzumab treatment for multiple sclerosis: another probable secondary autoimmune disease.

J Neurol 2019 Feb 25. Epub 2019 Feb 25.

Department of Neurology, Oslo University Hospital, 4956, 0424, Ullevål, Boks, Nydalen, Oslo, Norway.

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http://dx.doi.org/10.1007/s00415-019-09257-5DOI Listing
February 2019
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Cell Based Therapy for Type 1 Diabetes: Should We Take Hyperglycemia Into Account?

Front Immunol 2019 5;10:79. Epub 2019 Feb 5.

SOTIO a.s., Prague, Czechia.

Diabetes mellitus is characterized by long standing hyperglycemia leading to numerous life-threatening complications. For type 1 diabetes mellitus, resulting from selective destruction of insulin producing cells by exaggerated immune reaction, the only effective therapy remains exogenous insulin administration. Despite accurate compliance to treatment of certain patients, transient episodes of hyperglycemia cannot be completely eliminated by this symptomatic treatment. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370671PMC
February 2019
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Progression of Albuminuria Among Patients with Type 1 Diabetes Mellitus: A Long Term Observational Follow-up Study.

Exp Clin Endocrinol Diabetes 2019 Feb 25. Epub 2019 Feb 25.

Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece.

Background: The purpose of the present study was to determine whether patients with DM1 have shown improvement, stabilization or deterioration of their urine albumin excretion levels during a close follow-up.

Patients And Methods: A cohort of 84 patients, 18-76 years of age, a median duration of diabetes of 24 years (1-50 years) and a median follow-up duration of 12 years (1-37 years) were included in the study.

Results: Among the 84 patients for whom we had UAE levels at the beginning and by the end of the study, mean glycosylated hemoglobin was statistically significantly decreased during the follow-up period, from 8. Read More

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http://dx.doi.org/10.1055/a-0848-8076DOI Listing
February 2019
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Characteristics and clinical course of type 1 diabetes mellitus related to anti-programmed cell death-1 therapy.

Diabetol Int 2019 Jan 3;10(1):58-66. Epub 2018 Jul 3.

Sakai City Medical Center, Sakai, Osaka Japan.

Aims: We conducted a national survey to clarify the characteristics and clinical course of type 1 diabetes related to anti-programmed cell death-1 therapy.

Methods: We analyzed the detailed data of 22 patients that were collected using a Japan Diabetes Society survey and a literature database search.

Results: Among the 22 patients, 11 (50. Read More

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http://dx.doi.org/10.1007/s13340-018-0362-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357237PMC
January 2019