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    Comparison of adjunctive therapy with metformin and acarbose in patients with Type-1 diabetes mellitus.
    Pak J Med Sci 2017 May-Jun;33(3):686-690
    Maryam Honardoost, Assistant Professor of Molecular Medicine, Endocrine Research Center, Institute of Endocrinology and Metabolism, ran University of Medical Sciences, Tehran, Iran.
    Objective: All the aforementioned data have stimulated interest in studying other potential therapies for T1DM including noninsulin pharmacological therapies. The present study attempts to investigate the effect of adjunctive therapy with metformin and acarbose in patients with Type-1 diabetes mellitus.

    Method: In a single-center, placebo-controlled study (IRCT201102165844N1) we compared the results of two clinical trials conducted in two different time periods on 40 patients with Type-1 diabetes mellitus. Read More

    Regenerative medicine and cell-based approaches to restore pancreatic function.
    Nat Rev Gastroenterol Hepatol 2017 Aug 16. Epub 2017 Aug 16.
    Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
    The pancreas is a complex organ with exocrine and endocrine components. Many pathologies impair exocrine function, including chronic pancreatitis, cystic fibrosis and pancreatic ductal adenocarcinoma. Conversely, when the endocrine pancreas fails to secrete sufficient insulin, patients develop diabetes mellitus. Read More

    Budget impact of continuous subcutaneous insulin infusion therapy in patients with type 1 diabetes who experience severe recurrent hypoglycemic episodes in Spain.
    Endocrinol Diabetes Nutr 2017 Aug - Sep;64(7):377-383. Epub 2017 Jun 7.
    Unidad de Diabetes, Servicio de Endocrinología y Nutrición, ICMDiM, Hospital Clínic i Universitari de Barcelona, IDIBAPS, Barcelona, España.
    Objective: Hypoglycemia is one of the most common complications to achieve a good metabolic control, and has been listed by several scientific associations as a common indication to start treatment with continuous subcutaneous insulin infusion (CSII). Use of CSII is still residual in Spain as compared to neighbouring countries, and cost of acquisition cost is one of the main reasons. This study estimates the budget impact of treatment with CSII, as compared to multiple daily insulin injections, of patients with type 1 diabetes mellitus who experience recurrent severe hypoglycemia episodes from the National Healthcare System perspective. Read More

    Diabetes and pregnancy in Wistar rats: renal effects for mothers in the postpartum period.
    J Dev Orig Health Dis 2017 Aug 14:1-10. Epub 2017 Aug 14.
    1Area of Physiological Sciences,Federal University of Uberlândia,Uberlândia,Brazil.
    In this study, diabetes mellitus (DM) was induced in Wistar rats during pregnancy and maintained in the postpartum period (PP) and we evaluated systolic blood pressure (SBP), glomerular filtration rate (GFR) and renal immunohistochemical and morphometric studies from different groups: G1 (non-pregnant control rats), G2 (non-pregnant diabetic rats), G3 (control mothers) and G4 (diabetic mothers). We found that there were no differences in relation to SBP, but there was a tendency for reduction in GFR from G4 compared with the other groups (G). There was increased total kidney weight/body weight ratio of G4 compared with other G. Read More

    The Expression of Activating Receptor Gene of Natural Killer Cells (KLRC3) in Patients with 
Type 1 Diabetes Mellitus (T1DM).
    Oman Med J 2017 Jul;32(4):316-321
    Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
    Objectives: To identify the possible role of natural killer (NK) cells in the pathogenesis of type 1 diabetes mellitus (T1DM) through studying the expression of the KLRC3 gene, which encodes the NK cell activating receptor (NKG2E).

    Methods: This study was conducted at Alexandria University Children's Hospital from April to October 2015. The study was conducted with 30 newly diagnosed T1DM patients (15 males and 15 females), aged 7-13 years (10. Read More

    Sense of coherence, self-esteem, and health locus of control in subjects with type 1 diabetes mellitus with/without satisfactory metabolic control.
    J Endocrinol Invest 2017 Aug 12. Epub 2017 Aug 12.
    Unit of Metabolic Diseases and Clinical Dietetics, Department of Medical and Surgical Sciences, Policlinico S. Orsola, Via Massarenti, 9, "Alma Mater Studiorum" University, 40138, Bologna, Italy.
    Background: Despite intensive training, a few individuals with Type 1 diabetes mellitus (T1DM) fail to reach the desired metabolic targets.

    Aim: To evaluate the association between disease-related emotional and cognitive aspects and metabolic control in subjects with T1DM.

    Subjects And Methods: Health locus of control (HLOC), sense of coherence (SOC), and self-esteem were assessed in T1DM subjects using validated questionnaires. Read More

    Impact of monitoring health-related quality of life in clinical practice in children with type 1 diabetes mellitus.
    Qual Life Res 2017 Aug 12. Epub 2017 Aug 12.
    Health Services Research Unit, IMIM-Hospital del Mar Institute of Medical Research, Barcelona Biomedical Research Park (office 138.03), Dr Aiguader 88, 08003, Barcelona, Spain.
    Purpose: To test whether the systematic monitoring of health-related quality of life (HRQOL) in clinical practice in Spanish pediatric patients with T1DM helps improve their daily life in a multicenter longitudinal study.

    Methods: One hundred thirty-six patients participated, recruited from five centers in Barcelona, Spain (72 girls, mean age 13.4 years). Read More

    Cross-cultural adaption and psychometric properties of the Chinese version of the Diabetes Behavior Rating Scale: a pilot study.
    Sci China Life Sci 2017 Aug 10. Epub 2017 Aug 10.
    Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
    Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus (T1DM). The Diabetes Behavior Rating Scale (DBRS) has a potential to be the first mature instrument. Read More

    Levothyroxine enhances glucose clearance and blunts the onset of experimental type 1 diabetes mellitus in mice.
    Br J Pharmacol 2017 Aug 11. Epub 2017 Aug 11.
    Pancreatic Islet Development and Regeneration Unit/Laboratory of Aging Biology, Centro Andaluz de Biologı́a Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, 41092, Spain.
    Background And Purpose: Thyroid hormones induce several changes in whole body metabolism that are known to improve metabolic homeostasis. However, adverse side effects have prevented its use in the clinic. In view of the promising effects of thyroid hormones, we investigated the effects of levothyroxine supplementation in glucose. Read More

    Glucose-6-Phosphate Dehydrogenase Deficiency Unveiled by Diabetic Ketoacidosis: A Dual Dilemma.
    J Assoc Physicians India 2017 Aug;65(8):98-102
    Professor, Dept. of Medicine and Intensive Care, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra.
    An 18 year old male, known case of Type 1 Diabetes Mellitus was admitted in view of diabetic ketoacidosis. With normalization of blood sugars patient developed gross reddish discoloration of urine. Urine routine microscopy did not reveal RBCs or RBC casts. Read More

    Factors Associated with Greater Benefit of a National Reimbursement Policy for Blood Glucose Test Strips in Adult Patients with Type 1 Diabetes: A Prospective Cohort Study.
    J Diabetes Investig 2017 Aug 10. Epub 2017 Aug 10.
    Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Aims/introduction: We aimed to identify factors independently associated with greater benefit of a national reimbursement policy for blood glucose test strips in adult patients with type 1 diabetes (T1DM), in terms of glycemic control and rate of severe hypoglycemia.

    Materials And Methods: This was a prospective cohort study of 466 adult patients with T1DM from five tertiary referral hospitals who registered for a national reimbursement program for blood glucose strips and were then followed-up for 12 months. Factors associated with a >5% reduction in HbA1c and decreased rate of severe hypoglycaemia (SH) at 12 months from baseline were evaluated. Read More

    [One case of concurrent hemorrhage after pancreatic islet transplantation by percutaneous transhepatic portal approach].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 Aug;29(8):750-751
    Organ Transplantation Center, Tianjin First Center Hospital, Tianjin 300192, China (Zhang BY, Zhang YM, Wang ZP, Wang LJ); Tianjin Clinical Research Center for Organ Transplantation, Tianjin 300192, China (Pei GH, Wang SS); Key Laboratory for Critical Care Medicine of Ministry of Health, Tianjin 300100, China (Xie Y, Wang JS). Corresponding author: Wang Shusen, Email:
    Objective: The percutaneous transhepatic portal approach is the most commonly used technique for islet transplantation, largely owing to its safety and minimally invasive characteristic. Bleeding complications after islet transplantation are rare. A case of type 1 diabetes mellitus (T1DM) was treated in Tianjin First Center Hospital, who had a massive intra-abdominal hemorrhage after percutaneous transhepatic portal vein catheterization for islet transplantation. Read More

    Risk of low-energy fracture in type 2 diabetes patients: a meta-analysis of observational studies.
    Osteoporos Int 2017 Aug 9. Epub 2017 Aug 9.
    Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'an Road, Xicheng District, Beijing, 100050, China.
    In this meta-analysis, evidence of an association between type 2 diabetes mellitus (T2DM) and low-energy fractures has been evaluated including 12 observational studies. The results suggested that T2DM patients had an enhanced risk of low-energy fractures.

    Introduction: Type 1 diabetes mellitus (T1DM) patients have been shown to be at enhanced risk of fracture injury, but less is known about low-energy fractures among patients with T2DM. Read More

    Translation and cultural adaptation into Brazilian culture of type 1 diabetes distress scale.
    Diabetol Metab Syndr 2017 7;9:61. Epub 2017 Aug 7.
    Department of Family and Community Medicine, University of California San Francisco-UCSF, San Francisco, USA.
    Background: Diabetes related distress is common in type 1 diabetes patients (T1D). High levels of diabetes distress are related to poor metabolic control. An instrument to evaluate diabetes distress in T1D patients is "type 1 diabetes scale-T1DDS". Read More

    Standard body mass index reference data of prepubescent diabetic Egyptian children.
    J Pediatr Endocrinol Metab 2017 Aug 9. Epub 2017 Aug 9.
    Background: Data on the growth of diabetic children is conflicting. The aim of this study was to create and validate acceptable body mass index (BMI)-standardized percentiles and curves applied to Egyptian prepubescent diabetic children.

    Methods: The cross-sectional study comprised 822 prepubescent children with type 1 diabetes mellitus (T1DM), whose ages ranged from 3 years to 10 years±6 months. Read More

    Association of preterm birth and small for gestational age with metabolic outcomes in children and adolescents: A population-based cohort study from Taiwan.
    Pediatr Neonatol 2017 Jul 25. Epub 2017 Jul 25.
    Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
    Background: Previous studies have identified preterm birth and/or small for gestational age (SGA) as risk factors for features of the metabolic syndrome, including high blood pressure, insulin sensitivity and atherosclerosis, occurring later in life, with controversial results. We conducted this population-based cohort study to investigate metabolic outcomes in those with former preterm birth and/or SGA status in Taiwan.

    Methods: Data were obtained from Taiwan's universal National Health Insurance Research Database. Read More

    Bioprinting and Cellular Therapies for Type 1 Diabetes.
    Trends Biotechnol 2017 Aug 5. Epub 2017 Aug 5.
    Department of Engineering Science and Mechanics, Penn State University, University Park, PA, USA; Department of Biomedical Engineering, Penn State University, University Park, PA, USA; Huck Institutes of the Life Sciences, Penn State University, University Park, PA, USA; Materials Research Institute, Penn State University, University Park, PA, USA. Electronic address:
    Type 1 diabetes mellitus is a chronic autoimmune disease that results from the destruction of beta (β) cells in the pancreatic islets, leading to loss of insulin production and resultant hyperglycemia. Recent developments in stem cell biology have generated much excitement for β-cell replacement strategies; β cells are one of many cell types in the complex islet environment and pancreas. In this Opinion, we discuss recent successful attempts to generate β cells and how this can be coupled with bioprinting technologies in order to fabricate pancreas tissues, which holds great potential for type 1 diabetes. Read More

    Epidemiological and clinical peculiarities of polyglandular syndrome type 3 in pediatric age.
    Ital J Pediatr 2017 Aug 7;43(1):69. Epub 2017 Aug 7.
    UOC Pediatria, Department of Human Pathology in Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy.
    Background: Although the autoimmune polyglandular syndrome type 3 (APS-3) is the commonest APS that may be encountered in pediatric age, last year literature includes only few studies aiming to specifically ascertain the clinical spectrum of APS-3 in childhood and adolescence. Aims of these study were: a) to ascertain how many young patients with apparently isolated Hashimoto's thyroiditis (HT) are at risk of manifesting other autoimmune disorders (ADs) compatible with APS-3; b) to individuate the ADs which most frequently segregate with HT in the context of an APS-3.

    Methods: A selected population of 211 young patients with HT and no risk factors for other APSs was investigated, in order to evaluate the prevalence of other ADs apart from HT and to individuate the ADs which most frequently cluster with HT in the context of APS-3. Read More

    Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitus.
    Biomed Pharmacother 2017 Aug 4;94:619-626. Epub 2017 Aug 4.
    Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, 250012, China. Electronic address:
    Background: NLRP3 and NLRP1 inflammasomes signaling pathways may play an important role in the development and progression of type 1 diabetes mellitus (T1DM). However, relative research is rare.

    Methods: The blood mononuclear cells (PBMCs) and granulocytes (GCs) were collected from T1DM patients. Read More

    Influence of nutritional intervention on children with type 1 diabetes mellitus and DPP-4 in serum.
    Exp Ther Med 2017 Aug 9;14(2):913-916. Epub 2017 Jun 9.
    Department of Clinical Nutrition, Guangzhou Women and Children's Medical Center, Guangzhou, Guangdong 510623, P.R. China.
    The level of dipeptidyl peptidase-4 (DPP-4) of children with type 1 diabetes mellitus (T1DM) was observed to evaluate the improvement in function of the nutritional intervention. In total, 132 children with T1DM (T1DM group) and 132 healthy children (NC group) based on physical examination admitted to our hospital from September 2014 to June 2015 and were studied. General data of the two groups as well as the concentration of DPP-4 and various biochemical criterion in peripheral serum were collected and analyzed. Read More

    Evaluation of optic disc, retinal nerve fiber and macular ganglion cell layers in pediatric diabetes.
    Int Ophthalmol 2017 Aug 5. Epub 2017 Aug 5.
    Ophthalmology Department, Pamukkale University, 20070, Denizli, Turkey.
    Purpose: Our aim was to compare optic disc parameters, retinal nerve fiber (RNFL) and macular ganglion cell layers between children and adolescents with diabetes mellitus (type 1) and healthy controls.

    Methods: Sixty-three eyes of 63 pediatric diabetic patients without diabetic retinopathy and 44 eyes of 44 healthy controls were included in this cross-sectional and comparative study. Diabetic and control groups were similar in the aspect of age, gender and refractive error. Read More

    Is Type 1 Diabetes Mellitus More Prevalent Than Expected in Transgender Persons? A Local Observation.
    Sex Med 2017 Aug 1. Epub 2017 Aug 1.
    Department of Endocrinology and Center for Sexology and Gender, Ghent University Hospital, Ghent, Belgium.
    The International Diabetes Federation estimates that approximately 0.4% of the Belgian population is diagnosed with type 1 diabetes mellitus, which is similar to other industrialized countries. The prevalence of transgenderism is estimated at 0. Read More

    Liver up-regulation of ADAMTS13 gene expression and its correlation with renal markers in mice with type 1 diabetes mellitus and nephropathy.
    Thromb Res 2017 Jul 25;157:167-169. Epub 2017 Jul 25.
    Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address:

    The Application of One-Hour Static Qigong Program to Decrease Needle Pain of Korean Adolescents With Type 1 Diabetes: A Randomized Crossover Design.
    J Evid Based Complementary Altern Med 2017 Jan 1:2156587217722473. Epub 2017 Jan 1.
    1 Department of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, South Korea.
    The aim of this study was to describe application of a static Qigong program to decrease needle pain in Korean adolescents with type 1 diabetes and its pilot test results. The pilot study was a randomized crossover design including 26 adolescents randomized to Qigong or rest group. Participants received a 60-minute Qigong program consisted of warm up, deep breathing, imaginary, and a closing warm up. Read More

    Normoalbuminuric chronic kidney disease in type 1 diabetes: is it real and is it serious? Reply to Rigalleau V, Blanco L, Alexandre L et al [letter].
    Diabetologia 2017 Aug 2. Epub 2017 Aug 2.
    Diabetes and Metabolic Disease Section, Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Pisana, University of Pisa, 2 Via Paradisa, 56124, Pisa, Italy.

    The modulation of enzyme indoleamine 2,3-dioxygenase from dendritic cells for the treatment of type 1 diabetes mellitus.
    Drug Des Devel Ther 2017 24;11:2171-2178. Epub 2017 Jul 24.
    Department of Biomedical Science, Faculty of Americana, Americana, SP, Brazil.
    Diabetes mellitus type 1 (DM1) is an autoimmune disease in which β-cells of the pancreas islet are destroyed by T lymphocytes. Specific T cells are activated by antigen-presenting cells, mainly dendritic cells (DCs). It is already known that the regulation of tryptophan pathway in DC can be a mechanism of immunomodulation. Read More

    Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review.
    Intern Med 2017 1;56(15):1993-1999. Epub 2017 Aug 1.
    Department of Emergency and Critical Care Medicine, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Japan.
    A 65-year-old Japanese man with advanced chronic kidney disease (CKD) developed acute-onset type 1 diabetes mellitus (T1D) that was associated with severe acute kidney injury and was manifested by generalized tonic-clonic status epilepticus. His seizures resolved without recurrence after correcting the diabetic ketoacidosis. Although hyperglycemia is an important cause of acute symptomatic seizure (ASS), patients with ketotic hyperglycemia develop ASS less frequently. Read More

    Preeclampsia is associated with increased ambulatory arterial stiffness index in type 1 diabetes mellitus.
    Eur J Obstet Gynecol Reprod Biol 2017 Jul 25;216:153-158. Epub 2017 Jul 25.
    Department of Obstetrics/Gynecology, Herning Hospital, Denmark; Department of Obstetrics/Gynecology and Clinical Institute, Aarhus University Hospital, Denmark.
    Introduction: Treatment of mild to moderate hypertension might not benefit maternal or fetal outcome. This pessimistic point of view may have come about by using non-validated methods for measuring blood pressure in pregnancy combined with inadequate methodology for diagnosis, treatment, and monitoring effects.

    Aim: To determine the association between AASI in women with type 1 diabetes mellitus (T1DM) and preeclampsia, and to assess the ability of AASI to diagnose preeclampsia. Read More

    Prediction of glycaemic control in young children and adolescents with type 1 diabetes mellitus using mixed-effects logistic regression modelling.
    PLoS One 2017 2;12(8):e0182181. Epub 2017 Aug 2.
    School of Pharmacy, Pharmacy Australia Centre of Excellence (PACE), The University of Queensland, Woolloongabba, Queensland, Australia.
    Objectives: Glycaemic control in children and adolescents with type 1 diabetes mellitus can be challenging, complex and influenced by many factors. This study aimed to identify patient characteristics that were predictive of satisfactory glycaemic control in the paediatric population using a logistic regression mixed-effects (population) modelling approach.

    Methods: The data were obtained from 288 patients aged between 1 and 22 years old recorded retrospectively over 3 years (1852 HbA1c observations). Read More

    Incidence and prevalence of diabetic ketoacidosis (DKA) among adults with type 1 diabetes mellitus (T1D): a systematic literature review.
    BMJ Open 2017 08 1;7(7):e016587. Epub 2017 Aug 1.
    Xcenda L L C, Palm Harbor, Florida, USA.
    Objectives: To summarise incidence and prevalence of diabetic ketoacidosis (DKA) in adults with type 1 diabetes (T1D) for the overall patient population and different subgroups (age, sex, geographical region, ethnicity and type of insulin administration).

    Design: Systematic literature review (SLR).

    Data Sources: Medline (via PubMed) and Embase (1 January 2000 to 23 June 2016). Read More

    Patient diagnosed with chronic erectile dysfunction refractory to PDE 5 Inhibitor therapy reports improvement in function after hyperbaric oxygen therapy.
    Undersea Hyperb Med 2016 Jul-Aug;43(4):463-465
    Baylor Scott and White Comprehensive Wound Center, Irving, Texas U.S.
    Erectile dysfunction (ED), defined as the inability to achieve or sustain an erection firm enough for sexual intercourse, is common in men older than 50 years of age whose medical history includes diabetes mellitus. This case report describes a male patient treated with hyperbaric oxygen (HBO₂) therapy as part of a comprehensive wound treatment plan for an open right foot wound. The patient's medical history included Type 1 diabetes mellitus and chronic ED refractory to previous trials of phosphodiesterase type 5 inhibitors. Read More

    Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols.
    J Diabetes Res 2017 3;2017:5837804. Epub 2017 Jul 3.
    Institute of Life Science, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
    Diabetes mellitus is a chronic disease that threatens human health. The disease is caused by a metabolic disorder of the endocrine system, and long-term illness can lead to tissue and organ damage to the cardiovascular, endocrine, nervous, and urinary systems. Currently, the disease prevalence is 11. Read More

    Association between type 1 diabetes mellitus and risk of epilepsy: A meta-analysis of observational studies.
    Drug Discov Ther 2017 ;11(3):146-151
    Department of Structural Heart Disease, the First Affiliated Hospital of Xi'an Jiaotong University.
    A potential association between type 1 diabetes mellitus and subsequent epilepsy emerged in recent studies. This study aimed to evaluate the possible relationship between type 1 diabetes mellitus and epilepsy using meta-analysis. Pubmed, ISI Web of Knowledge, Embase and Cochrane Library were searched for potential studies of the association between type 1 diabetes mellitus and epilepsy from inception to February 1, 2017. Read More

    Environmental Risk Factors for Type 1 Diabetes Mellitus Development.
    Exp Clin Endocrinol Diabetes 2017 Jul 27. Epub 2017 Jul 27.
    Department of Medical Biology, University of Split, School of Medicine, Šoltanska 2, Split, Croatia.
    Background Although environmental factors induce development of type 1 diabetes mellitus (T1DM) in genetically susceptible individuals, many of those factors have been uncovered. Therefore, the aim of the present study was to analyze associations of T1DM with a wide range of environmental factors. Material and Methods A case-control study was conducted on 249 diabetic and 255 healthy individuals from the Dalmatian region of South Croatia. Read More

    Retinal Vessel Geometry and the Incidence and Progression of Diabetic Retinopathy.
    Invest Ophthalmol Vis Sci 2017 May;58(6):BIO200-BIO205
    Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical School, Singapore 2Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
    Purpose: To analyze the associations between retinal vessel geometry and the 1-year incidence and progression of diabetic retinopathy (DR) in a Chinese population.

    Methods: This was a prospective cohort study of adult subjects with diabetes mellitus. Retinal vascular geometry was quantified from fundus photographs using a semiautomated computer-assisted program. Read More

    Insulin resistance correlates with maculopathy and severity of retinopathy in young adults with Type 1 Diabetes Mellitus.
    Diabetes Res Clin Pract 2017 Jun 27;131:154-160. Epub 2017 Jun 27.
    Department of Endocrinology and Diabetes, John Hunter Hospital, Newcastle, Australia; School of Medicine and Public Health, University of Newcastle, Callaghan, Australia.
    Aims: To assess the relationship between insulin resistance (IR), retinopathy and maculopathy in young adults with Type 1 diabetes mellitus.

    Methods: A cross-sectional study at a regional Australian tertiary hospital. Retinal pathology, assessed by colour fundus photography, was correlated with two surrogate measures of IR: estimated Glucose Disposal Rate (eGDR) and Insulin Sensitivity Score (ISS), where lower scores reflect greater IR. Read More

    Comparative study of clinical features of patients with celiac disease & those with concurrent celiac disease & type 1 diabetes mellitus.
    Indian J Med Res 2017 Mar;145(3):334-338
    Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background & Objectives: Celiac disease (CD) and type 1 diabetes mellitus (T1DM) share a common genetic locus and clinical manifestations. The present study was planned to compare clinical, biochemical and hormonal profiles of patients with CD and CD with T1DM.

    Methods: Records of CD patients with age ≤20 yr, available anthropometric measurements, haematological, biochemical and hormonal workup with tissue transglutaminase IgA antibody and duodenal biopsy (Marsh grade) were screened. Read More

    The Yin and Yang Between Plasma Glucose Levels and Cortisol Replacement Therapy in Schmidt's Syndrome.
    J Investig Med High Impact Case Rep 2017 Jul-Sep;5(3):2324709617716203. Epub 2017 Jul 6.
    University of Florida, Gainesville, FL, USA.
    Objective: To illustrate how steroid replacement in adrenal insufficiency can influence the development of hypoglycemia in a patient with type 1 diabetes mellitus (T1D). Methods: We describe the case of a 36-year-old female patient with T1D and Addison's disease (Schmidt's syndrome) on multiple daily insulin injections who presented with recurrent hypoglycemia despite being on physiological replacement doses of hydrocortisone. Results: With the assistance of continuous glucose monitoring technology, a pattern of nocturnal hypoglycemia was clearly identified. Read More

    Severe hypertriglyceridemia at new onset type 1 diabetes mellitus.
    J Pediatr Endocrinol Metab 2017 Aug;30(8):893-897
    Background: Severe hypertriglyceridemia (HTG) as well as diabetic ketoacidosis (DKA) are complications of type 1 diabetes (T1DM). HTG is an exceedingly rare complication in the pediatric population and herein we report a case of HTG at new-onset T1DM in DKA and discuss management and potential complications.

    Case Presentation: An 11-year-old previously well patient with a history of fatigue and weight loss presented with: glucose >600 mg/dL, venous blood gas: pH 7. Read More

    Chaotic time series prediction for glucose dynamics in type 1 diabetes mellitus using regime-switching models.
    Sci Rep 2017 Jul 24;7(1):6232. Epub 2017 Jul 24.
    Department of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
    In patients with type 1 diabetes mellitus (T1DM), glucose dynamics are influenced by insulin reactions, diet, lifestyle, etc., and characterized by instability and nonlinearity. With the objective of a dependable decision support system for T1DM self-management, we aim to model glucose dynamics using their nonlinear chaotic properties. Read More

    Delayed graft duodenal perforation due to impacted food five years after simultaneous pancreas-kidney transplantation: A case report.
    Int J Surg Case Rep 2017 Jul 14;38:69-72. Epub 2017 Jul 14.
    Department of Surgery, Okayama Saiseikai General Hospital, Okayama, Japan.
    Introduction: Pancreas transplantation is the best treatment option in selected patients with type 1 diabetes mellitus. Here we report a patient with a nonmarginal duodenal perforation five years after a simultaneous pancreas-living donor kidney transplantation (SPLKT).

    Presentation Of Case: A 31-year old male who underwent SPLKT five years previously presented with severe abdominal pain. Read More

    The comparison of CHCA solvent compositions for improving LC-MALDI performance and its application to study the impact of aflatoxin B1 on the liver proteome of diabetes mellitus type 1 mice.
    PLoS One 2017 24;12(7):e0181423. Epub 2017 Jul 24.
    Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
    In nanoflow liquid chromatography-matrix-assisted laser desorption/ionization tandem time-of-flight (nanoLC-MALDI-TOF/TOF) approaches, it is critical to directly apply small amounts of the sample elutes on the sample target using a nanoLC system due to its low flow rate of 200 ~ 300 nl/min. It is recommended to apply a sheath liquid containing a matrix with a several μL/min flow rate at the end of the nanoLC column to ensure a larger co-eluted droplet for more reproducible sample spotting and avoid the laborious task of post-manual matrix spotting. In this study, to achieve a better nanoLC-MALDI performance on sample spotting, we first compared α-Cyano-4-hydroxycinnamic acid (CHCA) solvent composition for efficiently concentrating nanoLC elutes on an anchor chip. Read More

    Nephrolithiasis: A complication of pediatric diabetic ketoacidosis.
    Pediatr Diabetes 2017 Jul 24. Epub 2017 Jul 24.
    The Warren Alpert Medical School of Brown University, Providence, Rhode Island.
    Objective: To determine the frequency of nephrolithiasis as a complication of diabetic ketoacidosis (DKA) in pediatrics.

    Methods: We performed a retrospective chart review of patients with DKA admitted to a pediatric hospital between January 2009 and July 2016. We identified patients with nephrolithiasis during admission for DKA. Read More

    Autoimmune Hypoglycemia in Type 1 Diabetes Mellitus.
    Indian Pediatr 2017 Jul;54(7):593-594
    Department of Endocrinology, JIPMER, Pondicherry, India. Correspondence to: Dr Jayakumar Ambigapathy, Department of Endocrinology, JIPMER, Pondicherry 605 006, India.
    Background: Antibodies against exogenous insulin are common in type 1 diabetes mellitus patients. They can cause hypoglycemia, albeit uncommonly.

    Case Characteristics: A 14-year-old girl with type 1 diabetes mellitus presented with recurrent hypoglycemia. Read More

    Maternal-Fetal Outcomes in 34 Pregnant Women with Type 1 Diabetes in Sensor-Augmented Insulin Pump Therapy.
    Diabetes Technol Ther 2017 Jul;19(7):417-422
    1 Division of Endocrinology, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio , Bogotá, Colombia .
    Background: Pregnancy in women with type 1 diabetes (T1D) is associated with increased risk of maternal complications and neonatal morbidity and mortality. Optimizing glycemic control improves these outcomes.

    Objective: To describe the experience of using sensor-augmented insulin pump therapy (SAPT) and SAPT + low-glucose suspension (LGS) on pregnant women with T1D, including neonatal and maternal outcomes. Read More

    Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes.
    Sci Rep 2017 Jul 20;7(1):5998. Epub 2017 Jul 20.
    Diabetes Research Institute, University of Miami, Miami, FL, USA.
    Type 1 diabetes mellitus (T1DM) results from an autoimmune attack against the insulin-producing ß cells which leads to chronic hyperglycemia. Exosomes are lipid vesicles derived from cellular multivesicular bodies that are enriched in specific miRNAs, potentially providing a disease-specific diagnostic signature. To assess the value of exosome miRNAs as biomarkers for T1DM, miRNA expression in plasma-derived exosomes was measured. Read More

    Evidence that children born at early term (37-38 6/7 weeks) are at increased risk for diabetes and obesity-related disorders.
    Am J Obstet Gynecol 2017 Jul 18. Epub 2017 Jul 18.
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Background: Prematurity is known to be associated with high rates of endocrine and metabolic complications in the offspring. Offspring born early term (37-38 6/7 weeks' gestation) were also shown to exhibit long-term morbidity resembling that of late preterm, in several health categories.

    Objective: We aimed to determine whether early term delivery impacts on the long-term endocrine and metabolic health of the offspring. Read More

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