Search our Database of Scientific Publications and Authors

I’m looking for a

    72142 results match your criteria Diabetes Mellitus Type 1

    1 OF 1443

    Type 1 diabetes mellitus induces structural changes and molecular remodelling in the rat kidney.
    Mol Cell Biochem 2018 Feb 23. Epub 2018 Feb 23.
    School of Forensic and Applied Sciences, University of Central Lancashire, Preston, England, PR1 2HE, UK.
    There is much evidence that diabetes mellitus (DM)-induced hyperglycemia (HG) is responsible for kidney failure or nephropathy leading to cardiovascular complications. Cellular and molecular mechanism(s) whereby DM can damage the kidney is still not fully understood. This study investigated the effect of streptozotocin (STZ)-induced diabetes (T1DM) on the structure and associated molecular alterations of the isolated rat left kidney following 2 and 4 months of the disorder compared to the respective age-matched controls. Read More

    Prevalence of early and late prematurity is similar among pediatric type 1 diabetes mellitus patients and the general population.
    Diabetes Metab Res Rev 2018 Feb 22. Epub 2018 Feb 22.
    Pediatric Endocrinology Unit, Division of Pediatrics, Assaf Harofeh Medical Center, Zerifin, Israel.
    Background: The incidence of type 1 diabetes mellitus (T1DM) has increased in recent decades, as has the incidence of preterm births (<37 weeks). We aimed to evaluate and compare the prevalence of prematurity and early prematurity (<34 weeks) and birth season variability among T1DM and non-T1DM children.

    Methods: A nationwide cross-sectional study was conducted, with linkage of data from 13 pediatric diabetes centers and Israeli National Registries, including T1DM patients and general non-T1DM population, born during 2000-2013. Read More

    Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes.
    Mol Imaging Biol 2018 Feb 21. Epub 2018 Feb 21.
    Yale University, P.O. Box 208048, New Haven, CT, 06520-8048, USA.
    Purpose: Previous studies demonstrated the utility of [F]fluoropropyl-(+)-dihydrotetrabenazine ([F]FP-(+)-DTBZ) as a positron emission tomography (PET) radiotracer for the vesicular monoamine transporter type 2 (VMAT2) to quantify beta cell mass in healthy control (HC) and type 1 diabetes mellitus (T1DM) groups. Quantification of specific binding requires measurement of non-displaceable uptake. Our goal was to identify a reference tissue (renal cortex or spleen) to quantify pancreatic non-specific binding of [F]FP-(+)-DTBZ with the inactive enantiomer, [F]FP-(-)-DTBZ. Read More

    Type 1 diabetes mellitus and Graves' disease in Down's syndrome--a rare combination.
    Afr J Med Med Sci 2016 Sep;45(3):299-301
    Background: Autoimmune diseases including thyroid. disorders, type 1 diabetes and celiac disease are commoner in persons with Down's syndrome compared with the general population. Coexistent type 1 diabetes and hyperthyroidism in Down's syndrome is however not commonly reported in literature. Read More

    The relationship between hemoglobin level and the type 1 diabetic nephropathy in Anhui Han's patients.
    Intern Med J 2018 Feb 20. Epub 2018 Feb 20.
    Department of Nephrology, Anhui Provincal Hospital, Anhui Medical University, No 17 Lujiang Road, Hefei, 230001, China.
    Background: Recent studies have shown that low hemoglobin (Hb) level promote the progression of chronic kidney disease. This study assessed the relationship between Hb level and type 1 diabetic nephropathy (DN) in Anhui Han's patients.

    Methods: There were a total of 236 patients diagnosed with type 1 diabetes mellitus and (T1DM) seen between January 2014 and December 2016 in our centre. Read More

    Growth Trajectory in Children with Type 1 Diabetes Mellitus: The Impact of Insulin Treatment and Metabolic Control.
    Horm Res Paediatr 2018 Feb 16. Epub 2018 Feb 16.
    Diabetes Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
    Background: Linear growth was reported to be negatively affected by type 1 diabetes mellitus (T1DM), in relation to disease duration and poor metabolic control. It is unclear whether a subtle growth failure still persists despite the optimization of therapy. Our aim was to analyse pubertal growth, adult height, and metabolic profile in a cohort of children with T1DM undergoing intensive insulin treatment by multiple daily injections or continuous subcutaneous insulin infusion (CSII). Read More

    Dimethyl fumarate in a patient with multiple sclerosis and type 1 diabetes mellitus: The importance of ketonuria.
    Mult Scler Relat Disord 2018 Feb 7;21:42-45. Epub 2018 Feb 7.
    Department of Children's Diabetology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
    Background: Dimethyl fumarate (DMF) is approved for use in patients with relapsing-remitting multiple sclerosis (MS). Its mechanism of action is still not well understood, but besides the immunological pathways in MS, it may also affect the metabolism of normally functioning internal organs, tissues and cells.

    Case Presentation: We report on the case of 29-year-old woman with satisfactorily-controlled type 1 diabetes (T1D), who was diagnosed as having MS. Read More

    Circulating miRNA Profiles Associated With Hyperglycemia in Patients With Type 1 Diabetes Mellitus.
    Diabetes 2018 Feb 16. Epub 2018 Feb 16.
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA 02215
    We investigated plasma microRNA (miRNA) profiles associated with variation of hyperglycemia, measured as hemoglobin A(HbA), in two panels of patients with type 1 diabetes (T1D). Using the HTG Molecular Diagnostics EdgeSeq platform, 2,083 miRNAs were measured in plasma from 71 patients included in a screening panel. Quantitative real-time polymerase chain reaction was used to measure the candidate miRNAs in plasma from 95 patients included in an independent replication panel. Read More

    Dipeptidyl peptidase-4 inhibitors (DPP-4i) combined with vitamin D3: An exploration to treat new-onset type 1 diabetes mellitus and latent autoimmune diabetes in adults in the future.
    Int Immunopharmacol 2018 Feb 13;57:11-17. Epub 2018 Feb 13.
    Post-graduation in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso(UFMT), Av. Fernando Corrêa da Costa, 2367, Boa Esperança, CEP:78060-900 Cuiabá, Mato Grosso, Brazil.
    Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic beta cells through cell injury caused primarily by cytotoxic T lymphocytes (CD8). The pathophysiological basis of T1DM seems to be an imbalance between a reduced function of T regulatory lymphocytes and an increased inflammatory activity of Th17 lymphocytes caused by increased production of inflammatory cytokines, as IL-1β, IL-6, IL-17 and IFN-gamma due to environmental factors and genetic predisposition. The preservation of the reserve of beta cells in new-onset T1DM and latent autoimmune diabetes in adults (LADA) by immunomodulation in addition to the incretin effect seems to be possible with an association of DPP-4 inhibitors and vitamin D3. Read More

    Role of adipose tissue derived stem cells differentiated into insulin producing cells in the treatment of type I diabetes mellitus.
    Gene 2018 Feb 13. Epub 2018 Feb 13.
    Clinical pathology Department, Faculty of Medicine, Zagazig University, Egypt.
    Generation of new β cells is an important approach in the treatment of type 1 diabetes mellitus (type 1 DM). Adipose tissue-derived stem cells (ADSCs) might be one of the best sources for cell replacement therapy for diabetes. Therefore, this work aimed to test the possible role of transplanted insulin-producing cells (IPCs) differentiated from ADSCs in treatment of streptozotocin (STZ) induced type I DM in rats. Read More

    Influence of hyperbaric oxygen on biomechanics and structural bone matrix in type 1 diabetes mellitus rats.
    PLoS One 2018 16;13(2):e0191694. Epub 2018 Feb 16.
    Department of Histology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
    Background: The aim of this study was to evaluate the biomechanics and structural bone matrix in diabetic rats subjected to hyperbaric oxygen therapy (HBO).

    Methods: Twenty-four male rats were divided into the following groups: Control; Control + HBO; Diabetic, and Diabetic + HBO. Diabetes was induced with streptozotocin (STZ) in the diabetic Groups. Read More

    Sodium-glucose co-transporter 2 (SGLT2) inhibitors as add-on therapy to insulin for type 1 diabetes mellitus: Systematic review and meta-analysis of randomized controlled trials.
    Diabetes Obes Metab 2018 Feb 16. Epub 2018 Feb 16.
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Japan.
    New treatments for type 1 diabetes are an unmet need. We investigated the efficacy and safety of adding SGLT-2is to insulin for type 1 diabetes by meta-analysis of prospective randomized, placebo-controlled trials. Searching electronic databases up to October 2017 identified 1361 studies, among which 14 were investigated (N=4,591). Read More

    Clinical Profile of Diabetic Ketoacidosis in Adults in Dhulikhel Hospital.
    Kathmandu Univ Med J (KUMJ) 2017 Jan.-Mar.;15(57):25-28
    Department of Medicine, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Kavre, Nepal.
    Background Diabetic ketoacidosis is one of the life-threatening acute complications of diabetes mellitus. Despite the improvements in diabetic care, it remains a major clinical problem in clinical practice. Objective To assess the clinical and laboratory profile of adults with diabetic ketoacidosis in Dhulikhel hospital. Read More

    Different Methods for Modelling Severe Hypoglycaemic Events: Implications for Effectiveness, Costs and Health Utilities.
    Pharmacoeconomics 2018 Feb 14. Epub 2018 Feb 14.
    Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
    Background: Clinical trials report severe hypoglycaemic events as the number of patients with at least one event out of the total randomised or number of events for a given total exposure. Different network meta-analysis models have been used to analyse these different data types.

    Objective: This aim of this article was to establish the impact of using the different models on effectiveness, costs and health utility estimates. Read More

    Higher concentrations of osteoprotegerin in type 1 diabetic patients are related to retinopathy: Results from the Poznań Prospective Study.
    Adv Clin Exp Med 2017 Dec;26(9):1343-1349
    Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poland.
    Background: Osteoprotegerin (OPG) is an arterial calcification marker which has been associated with vascular damage. Elevated OPG concentrations associated with low-grade inflammatory processes are found in diabetic subjects.

    Objectives: The aim of the study was to assess concentrations of OPG in relation to the presence of diabetic complications in patients with diabetes type 1 (DM 1) participating in the Poznań Prospective Study (PoProStu). Read More

    Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina.
    Clin Exp Ophthalmol 2018 Feb 14. Epub 2018 Feb 14.
    Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
    Background: Neuropeptide Y (NPY) is a neuromodulator that is expressed in the retina. Increasing evidence suggests that NPY has pronounced anti-inflammatory effects, which might depend on the inhibition of dipeptidyl-peptidase-IV (DPP-IV). The aim of this study was to investigate the impact of type 1 diabetes mellitus (DM) and sitagliptin, a DPP-IV inhibitor, on the NPY system in the retina using an animal model. Read More

    The autoimmune ecology: an update.
    Curr Opin Rheumatol 2018 Feb 12. Epub 2018 Feb 12.
    Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
    Purpose Of Review: The autoimmune ecology refers to the interactions between individuals and their environment leading to a breakdown in immune tolerance and, therefore, to the development of one or more autoimmune diseases in such an individual. Herein, an update is offered on four specific factors associated with autoimmune diseases, namely, vitamin D, smoking, alcohol and coffee consumption from the perspective of exposome and metabolomics.

    Recent Findings: Smoking is associated with an increased risk for most of the autoimmune diseases. Read More

    Concomitant administration of resveratrol and insulin protects against diabetes mellitus type-1-induced renal damage and impaired function via an antioxidant-mediated mechanism and up-regulation of Na/K-ATPase.
    Arch Physiol Biochem 2018 Feb 13:1-10. Epub 2018 Feb 13.
    a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    This study investigated if a combination of resveratrol (RES) and insulin could reverse type 1 diabetic mellitus-induced (T1DM) nephropathy and illustrates mechanism of action. Rats were divided into six groups (n = 10/group) as follows: control, control + RES (20 mg/kg), T1DM, T1DM + RES, T1DM + insulin (1 U/g), and T1DM + RES + insulin and treated for eight weeks. While individual administrations of both drugs significantly but partially restored renal function and cortex architectures, combination therapy of both RES and insulin produced the maximum improvements. Read More

    Identification of bioactive heterocyclic compounds from mulberry and their protective effect against streptozotocin-induced apoptosis in INS-1 cells.
    Mol Med Rep 2018 Feb 8. Epub 2018 Feb 8.
    College of Korean Medicine, Gacheon University, Seongnam, Gyeonggi 13120, Republic of Korea.
    A phytochemical investigation of the MeOH extracts from mulberries (the fruit of Morus alba L.) led to the identification of six heterocyclic compounds (1‑6). These compounds were screened to detect whether they protected pancreatic INS‑1 cells from streptozotocin (STZ)‑induced cytotoxicity. Read More

    Generation of high-yield insulin producing cells from human-induced pluripotent stem cells on polyethersulfone nanofibrous scaffold.
    Artif Cells Nanomed Biotechnol 2018 Feb 12:1-7. Epub 2018 Feb 12.
    a Stem Cell Technology Research Center , Tehran , Iran.
    Transplantation of islet is a promising method in treatment of patients with type 1 diabetes mellitus (T1DM), however, is limited by islet shortage. The aim of this study was to prepare a polyethersulfone (PES) nanofibrous scaffolds to evaluate the pancreatic differentiation of human induced pluripotent stem cells (hiPSCs). The differentiation process in tissue culture dishes and PES scaffolds was evaluated at mRNA and protein level by RT-qPCR and immunofluorescence assay, respectively. Read More

    Ketoacidosis in Newly Diagnosed Type 1 Diabetes in Children and Adolescents in Israel: Prevalence and Risk Factors.
    Isr Med Assoc J 2018 Feb;20(2):100-103
    Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
    Background: Diabetic ketoacidosis (DKA) as the first presentation of type 1 diabetes mellitus (T1DM) is a serious complication that is preventable.

    Objectives: To identify risk factors for DKA at presentation of T1DM to delineate high-risk Israeli populations that could benefit from preventative measures.

    Methods: Data for this multicenter retrospective study were collected from the medical files of three pediatric diabetes centers representing three districts in Israel. Read More

    High Prevalence and Incidence of Diabetic Peripheral Neuropathy in Children and Adolescents With Type 1 Diabetes Mellitus: Results From a Five-Year Prospective Cohort Study.
    Pediatr Neurol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Pediatrics, Academic Teaching Hospital, Landeskrankenhaus Feldkirch, Feldkirch, Austria.
    Background: In this prospective cohort study, we investigated the prevalence of diabetic peripheral neuropathy at baseline and after five years of follow-up in children and adolescents with type 1 diabetes mellitus using both measurements of nerve conduction velocity and clinical neurological examination.

    Methods: A total of 38 patients who underwent insulin pump or intensive insulin therapy were included. The subjects averaged 12. Read More

    Rapidly progressive neovascular glaucoma following coronary artery bypass graft surgery in a patient with type 1 diabetes mellitus: a case report.
    J Med Case Rep 2018 Feb 12;12(1):36. Epub 2018 Feb 12.
    Royal Eye Infirmary, Level 3, Derriford Hospital, Plymouth, PL6 8DH, UK.
    Background: Proliferative diabetic retinopathy leading to vitreous hemorrhage, tractional retinal detachment, and neovascular glaucoma is a major cause of severe sight impairment in adults of working age worldwide. Neovascular glaucoma occurs in 2.5% of patients with proliferative diabetic retinopathy, which is difficult to treat and often leads to blindness. Read More

    Metabolic control and complications in Italian people with diabetes treated with continuous subcutaneous insulin infusion.
    Nutr Metab Cardiovasc Dis 2017 Dec 9. Epub 2017 Dec 9.
    Metabolic Diseases, Department of Medicine-DIMED, University of Padua, Padua, Italy. Electronic address:
    Background And Aim: The objective of this cross-sectional study was to evaluate the degree of glycaemic control and the frequency of diabetic complications in Italian people with diabetes who were treated with continuous subcutaneous insulin infusion (CSII).

    Methods And Results: Questionnaires investigating the organisation of diabetes care centres, individuals' clinical and metabolic features and pump technology and its management were sent to adult and paediatric diabetes centres that use CSII for treatment in Italy. Information on standard clinical variables, demographic data and acute and chronic diabetic complications was derived from local clinical management systems. Read More

    Intravenous Infusion of Human Adipose Tissue-Derived Mesenchymal Stem Cells to Treat Type 1 Diabetic Mellitus in Mice: An Evaluation of Grafted Cell Doses.
    Adv Exp Med Biol 2018 Feb 9. Epub 2018 Feb 9.
    Stem Cell Institute, University of Science, VNUHCM, Ho Chi Minh city, Vietnam.
    Mesenchymal stem cell (MSC) transplantation is a novel treatment for diabetes mellitus, especially type 1 diabetes. Many recent publications have demonstrated the efficacy of MSC transplantation on reducing blood glucose and increasing insulin production in both preclinical and clinical trials. However, the investigation of grafted cell doses has been lacking. Read More

    Management of T1DM in children and adolescents in primary care.
    Malays Fam Physician 2017 31;12(2):18-22. Epub 2017 Aug 31.
    Hospital Kajang, Selangor, Malaysia E-mail:
    The Clinical Practice Guidelines on the Management of Type 1 Diabetes Mellitus in Children & Adolescents was developed by a multidisciplinary development group and approved by the Ministry of Health Malaysia in 2015. A systematic review of 15 clinical questions was conducted using the evidence retrieved mainly from MEDLINE and Cochrane databases. Critical appraisal was done using the Critical Appraisal Skills. Read More

    Screen-detected gallstone disease and autoimmune diseases - A cohort study.
    Dig Liver Dis 2018 Jan 31. Epub 2018 Jan 31.
    Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; The Faculty of Medicine, Aalborg University, Denmark. Electronic address:
    Background: Gallstone disease is highly prevalent and is associated with systemic inflammation.

    Aims: To determine whether screen-detected gallstones or cholecystectomy are associated with the occurrence of autoimmune and autoinflammatory diseases and the most common subgroups thereof.

    Methods: A cohort study of three randomly selected general population samples from Copenhagen was performed. Read More

    Evaluation of vitamin D receptor gene polymorphisms (Fok-I and Bsm-I) in T1DM Saudi children.
    J Clin Lab Anal 2018 Feb 8. Epub 2018 Feb 8.
    Pediatrics and Genetics Department, Faculty of Medicine, Mansoura University, Al-Mansoura, Egypt.
    Background: Vitamin D deficiency conferred strongest susceptibility to pathogenesis of type 1 diabetes mellitus (T1DM). Altered gene expression and function have strong effect on VDR gene polymorphism.

    Objectives: We aimed to check for the association of two single nucleotide polymorphisms (SNPs) in VDR gene (Fok-I and Bsm-I) with T1DM in Saudi children. Read More

    A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes.
    Diabetologia 2018 Feb 7. Epub 2018 Feb 7.
    Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, EX2 5AD, UK.
    Aims/hypothesis: Identifying individuals suitable for monogenic autoimmunity testing and gene discovery studies is challenging: early-onset type 1 diabetes mellitus can cluster with additional autoimmune diseases due to shared polygenic risk and islet- and other organ-specific autoantibodies are present in both monogenic and polygenic aetiologies. We aimed to assess whether a type 1 diabetes genetic risk score (GRS) could identify monogenic autoimmune diabetes and be useful to prioritise individuals for gene discovery studies.

    Methods: We studied 79 individuals with diabetes and at least one additional autoimmune disease diagnosed before the age of 5 years. Read More

    Impact of Insulin Delivery Method on Hypoglycemia Incidence in Pediatric Type 1 Diabetes Mellitus Patients.
    Med Arch 2017 Dec;71(6):391-395
    PhD Student, Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina.
    Introduction: Insulin therapy of pediatric patients with type 1 diabetes mellitus (T1DM) is highly demanding due to their dynamic growth, development and different daily life activities.

    Goal: To determine the optimal insulin delivery method for the prevention of hypoglycemia recorded by continuous monitoring of glucose in patients with insulin pump and PEN.

    Material And Methods: The study included patients up to 18 years of age with diagnosed T1DM and treated with insulin pump and by insulin therapy with PEN at the Pediatric Clinic of the Clinical Center in Sarajevo. Read More

    Impact of experimental diabetes and chronic hypoxia on rat fetal body weight.
    Ginekol Pol 2018 ;89(1):20-24
    Chair and Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Poland.
    Objectives: The aim of the study is to determine the impact of the experimental diabetes and the chronic hypoxia on pregnancy development and rat fetal body weight.

    Material And Methods: The experiment was performed on female Wistar rats. Animals were divided into the experimen-tal groups. Read More

    Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus.
    Clin Biochem 2018 Feb 2. Epub 2018 Feb 2.
    Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
    Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM.

    Design And Methods: Study included 201 subjects with T1DM (14. Read More

    Cost calculation for a flash glucose monitoring system for UK adults with type 1 diabetes mellitus receiving intensive insulin treatment.
    Diabetes Res Clin Pract 2018 Feb 1. Epub 2018 Feb 1.
    Device Access UK Ltd, Albertine House, Michelmersh, Hampshire S051 OAG, UK.
    Aims: To estimate the costs associated with a flash glucose monitoring system as a replacement for routine self-monitoring of blood glucose (SMBG) in patients with type 1 diabetes mellitus (T1DM) using intensive insulin, from a UK National Health Service (NHS) perspective.

    Methods: The base-case cost calculation was created using the maximum frequency of glucose monitoring recommended by the 2015 National Institute for Health and Care Excellence guidelines (4-10 tests per day). Scenario analyses considered SMBG at the frequency observed in the IMPACT clinical trial (5. Read More

    Layer-by-layer cell coating technique using extracellular matrix facilitates rapid fabrication and function of pancreatic β-cell spheroids.
    Biomaterials 2018 Jan 16;160:82-91. Epub 2018 Jan 16.
    Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan. Electronic address:
    Tissue engineering of insulin-secreting cells using alternatives to islet transplantation has been fueled by the development of available materials and fabrication techniques. We have established a cell coating technique that enables the cell surface to be coated with extracellular matrix based on the concept of a layer-by-layer (LbL) assembly. The present study evaluated whether this technique is beneficial for fabricating pancreatic β-cell spheroids using a mouse β-cell line. Read More

    Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes Mellitus: Implications of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study 30-Year Follow-up.
    Endocrinol Metab Clin North Am 2018 Mar 11;47(1):65-79. Epub 2017 Dec 11.
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, 4245 Roosevelt Way Northeast, Box 354691, Seattle, WA 98105, USA.
    Type 1 diabetes mellitus, an autoimmune disorder characterized by beta-cell destruction and absolute insulin deficiency, is associated with significantly increased cardiovascular disease risk but the mechanisms underlying this enhanced risk are unclear. Results of the pivotal Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study have shown that compared to conventional therapy, intensive glycemic control results in decreased cardiovascular morbidity and mortality. Evidence from this study also revealed contributions of blood pressure, renal disease, body weight, and lipids to cardiovascular disease in type 1 diabetes mellitus. Read More

    Sleep in Type 1 Diabetes: Implications for Glycemic Control and Diabetes Management.
    Curr Diab Rep 2018 Feb 5;18(2). Epub 2018 Feb 5.
    Vanderbilt University Medical Center, Village at Vanderbilt, 1500 21st Ave. South, Suite 1514, Nashville, TN, 37212, USA.
    Purpose Of Review: To highlight recent findings from studies of sleep in type 1 diabetes (T1D), with a focus on the role of sleep in self-management, the cognitive and psychosocial outcomes related to sleep disturbances, and factors associated with sleep disturbances specific to T1D.

    Recent Findings: People with T1D experience higher rates of sleep disturbances than people without diabetes, and these disturbances have negative implications for glycemic control and diabetes management, as well as psychosocial and cognitive outcomes. Inconsistent sleep timing (bedtime and wake time) has emerged as a potential target for interventions, as variability in sleep timing has been linked with poorer glycemic control and adherence to treatment. Read More

    Circulating soluble klotho is not associated with an elevated ankle-brachial index as a surrogate marker of early arterial calcification in patients with type 1 diabetes mellitus and no evidence of renal dysfunction.
    Diabetes Metab 2018 Jan 18. Epub 2018 Jan 18.
    Department of Endocrinology and Nutrition, 28034 Madrid, Spain; Diabetes, Obesity and Human Reproduction Research Group, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid & Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28034 Madrid, Spain.

    Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1.
    Eur J Pediatr 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pediatrics, Juliana Children's Hospital/Haga Teaching Hospital, Els Borst-Eilersplein 275, zip code, 2545, AA, The Hague, the Netherlands.
    Children with diabetes mellitus (DM) type 1 may be at risk for iron deficiency (ID) although this has been little studied. ID is either an absolute (depleted iron stores) or a functional (restricted iron stores due to chronic inflammation) deficiency each requiring a different therapeutic approach. Unfortunately, absolute ID is often not distinguished from functional ID. Read More

    Population-Based Cohort Study on Dementia Risk in Patients with Type 1 Diabetes Mellitus.
    Neuroepidemiology 2018 Feb 1;50(1-2):57-62. Epub 2018 Feb 1.
    Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
    Background: The risk of dementia increases by 15-28% in patients with type 2 diabetes mellitus (DM). However, studies on dementia risk in type 1 DM have been neither comprehensive nor conclusive.

    Methods: We carried out a cohort study involving 1,077 patients registered to have type 1 DM from 1998 to 2009 and 32,310 matched non-DM controls who were selected from Taiwan National Health Insurance Claims. Read More

    A systematic review of urinary bladder hypertrophy in experimental diabetes: Part I. Streptozotocin-induced rat models.
    Neurourol Urodyn 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany.
    Aims: To better understand the genesis and consequences of urinary bladder hypertrophy in animal models of diabetes. This part of a three-article series will analyze urinary bladder hypertrophy in the diabetes mellitus type 1 model of rats injected with streptozotocin (STZ).

    Methods: A systematic search for the key word combination "diabetes," "bladder" and "hypertrophy" was performed in PubMed; additional references were identified from reference lists of those publications. Read More

    Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress.
    Endocrine 2018 Feb 1. Epub 2018 Feb 1.
    Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.
    Purpose: Suppression of inflammation and oxidative stress is an attractive strategy to against diabetic cardiomyopathy (DCM). Kaempferol (KPF) exerts both anti-inflammatory and antioxidant pharmacological properties. However, little is known about the effect of KPF on protecting myocardial injury in diabetes. Read More

    Environmental Toxicant Exposures and Type 2 Diabetes Mellitus: Two Interrelated Public Health Problems on the Rise.
    Curr Opin Toxicol 2018 Feb 12;7:52-59. Epub 2017 Oct 12.
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
    Rates of type 2 diabetes mellitus (T2DM) are rising rapidly across the globe and the impact of this devastating disease threatens to plague the 21century. While some contributing factors are well-recognized (e.g. Read More

    Atorvastatin and insulin equally mitigate brain pathology in diabetic rats.
    Toxicol Appl Pharmacol 2018 Mar 31;342:79-85. Epub 2018 Jan 31.
    Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:
    Although insulin and atorvastatin have been shown to exert glycemic control and could improve brain function, the effects of atorvastatin or insulin as well as the combination of atorvastatin plus insulin on brain pathology in diabetes mellitus type 1 (T1DM) are unclear. Therefore, this study investigated the effect of atorvastatin, insulin or combined drugs on brain pathology in streptozotocin-induced diabetic rats. Thirty-six male rats were divided into two groups, a control group (n = 12) and a diabetic or experimental group (n = 24). Read More

    Well-being, diabetes management and breastfeeding in mothers with type 1 diabetes - An explorative analysis.
    Sex Reprod Healthc 2018 Mar 16;15:77-82. Epub 2017 Dec 16.
    Centre for Person-Centred Care, Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Objectives: The aim was to explore and investigate associations between well-being, diabetes management and breastfeeding in mothers with type 1 diabetes mellitus (T1DM) up to six months postpartum.

    Methods: An explorative analysis of self-reported questionnaires measuring general well-being, sense of coherence, self-efficacy of diabetes management and experiences of diabetes management during breastfeeding, which were distributed to 155 mothers with T1DM at two months and at six months after childbirth. The questionnaires were answered by 128 (82. Read More

    1 OF 1443