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    Association of Glycosylated Hemoglobin Levels With Vitamin D Status.
    J Clin Med Res 2017 Dec 6;9(12):1013-1018. Epub 2017 Nov 6.
    Obesity, Endocrine and Metabolism Center, King Fahad Medical City (KFMC), Riyadh, Saudi Arabia.
    Background: The discovery of vitamin D is one of medicine's great achievements. Despite all the positive evidence emerging about the beneficial effect of vitamin D, we still find many are vitamin D deficient. The purposes of this study were to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and glycosylated hemoglobin (HbA1c) levels, to test the hypothesis that lower 25(OH)D levels are associated with poorer glucose control in diabetes mellitus (DM) patients and to investigate the effect of vitamin D supplementation on HbA1c levels. Read More

    Can Antioxidative Status Be Involved in Type 1 Diabetes?
    J Clin Med Res 2017 Dec 6;9(12):998-1001. Epub 2017 Nov 6.
    CINTESIS, Center for Research in Health Technologies and Information Systems, Porto, Portugal.
    Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disease with beta-cell destruction, resulting in insulin deficiency. It is now clear that environmental factors also play a role in disease development. The prevalence of type 1 diabetes in children and young people in Portugal is 0. Read More

    Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases.
    Front Microbiol 2017 7;8:2164. Epub 2017 Nov 7.
    Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
    The morbidity associated with atopic diseases and immune dysregulation disorders such as asthma, food allergies, multiple sclerosis, atopic dermatitis, type 1 diabetes mellitus, and inflammatory bowel disease has been increasing all around the world over the past few decades. Although the roles of non-biological environmental factors and genetic factors in the etiopathology have been particularly emphasized, they do not fully explain the increase; for example, genetic factors in a population change very gradually. Epidemiological investigation has revealed that the increase also parallels a decrease in infectious diseases, especially parasitic infections. Read More

    Diabetes Data Management System to Improve Glycemic Control in People With Type 1 Diabetes: Prospective Cohort Study.
    JMIR Mhealth Uhealth 2017 Nov 21;5(11):e170. Epub 2017 Nov 21.
    Metabolic Diseases Unit, Department of Clinical and Experimental Medicine, University of Catanzaro, Catanzaro, Italy.
    Background: Smartphone and Web technology can improve the health care process, especially in chronic diseases.

    Objective: The aim of this study was to investigate whether the use of blood glucose (BG) data management system, which enables connection to smartphones, the Web, the cloud, and downloading, can improve glycemic control in subjects with type 1 diabetes mellitus (T1DM).

    Methods: This study was a prospective, single-arm, cohort feasibility study with 6 months of duration. Read More

    Pharmacokinetics and pharmacodynamics of insulin glargine-insulin glulisine basal-bolus and twice-daily premixed analog insulin in type 1 diabetes mellitus patients during three standardized meals.
    J Clin Transl Endocrinol 2016 Mar 24;3:14-20. Epub 2015 Dec 24.
    University of Maryland Medical Center, 22 South Greene St. N3W42, Baltimore, MD 21201.
    Aims: To evaluate the pharmacokinetics and pharmacodynamics of basal insulin glargine with mealtime insulin glulisine or twice daily 75/25 premixed neutral protamine insulin lispro and insulin lispro in individuals with type 1 diabetes during three standardized meals over a 24 hour duration and compare to physiologic insulin and glucose responses in healthy non-diabetic individuals.

    Methods: Twelve healthy (4 male/8 female) and thirteen individuals with type 1 diabetes (8 male/5 female) were studied during three sequential standardized meals. Individuals with type 1 diabetes received either glargine and glulisine injected 5 minutes subcutaneously before each meal or premixed insulin lispro injected 5 minutes before breakfast and dinner in a randomized fashion separated by eight weeks. Read More

    Autoimmune response to AGE modified human DNA: Implications in type 1 diabetes mellitus.
    J Clin Transl Endocrinol 2014 Sep 25;1(3):66-72. Epub 2014 Jun 25.
    Department of Biochemistry, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.
    Aims: Non-enzymatic glycation of DNA both in vivo and in vitro results in generation of free radicals, known as glycoxidation. Glycoxidation leads to structural perturbation of DNA resulting in generation of neo-antigenic epitopes having implication in autoimmune disorders like diabetes mellitus. In this study human placental DNA was glycated with methylglyoxal (MG) and lysine (Lys) in the presence of Cu(2+) and its auto-antibody binding was probed in Type 1 diabetes patients. Read More

    The Physiological and Glycaemic Changes in Breastfeeding Women with Type 1 Diabetes Mellitus.
    Diabetes Res Clin Pract 2017 Nov 14. Epub 2017 Nov 14.
    The University of Queensland, Brisbane, Queensland 4072, Australia; Royal Brisbane and Women's Hospital, Herston, Queensland 4029, Australia.
    The World Health Organisation recommends exclusive breastfeeding for the first six months of life ([1]. Breastfeeding confers many short- and long-term benefits for infants and mothers, including reduced childhood obesity and lower maternal body weight [2-6]. Exclusive breastfeeding is also recommended in women with type 1 diabetes mellitus (T1DM), for at least four months [7]. Read More

    Generation of insulin-producing cells from human adipose-derived mesenchymal stem cells on PVA scaffold by optimized differentiation protocol.
    J Cell Physiol 2017 Nov 18. Epub 2017 Nov 18.
    Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
    The studies have been done on patient-specific human adipose-derived from mesenchymal stem cells (hADSCs) like a series of autologous growth factors and nanofibrous scaffolds (3D culture) will probably have many benefits for regenerative medicine in type 1 diabetes mellitus (TIDM) patients in the future. For this purpose, we established a polyvinyl alcohol (PVA) scaffold and a differentiation protocol by adding platelet-rich plasma (PRP) that induces the hADSCs into insulin-producing cells (IPCs). The Characteristics of the derived IPCs in 3D culture were compared with conventional culture (2D) groups evaluated at the mRNA and protein levels. Read More

    [The situation as regards diabetes mellitus type 1 in Andalusia. Care data, use of advanced therapies and human resources].
    An Pediatr (Barc) 2017 Nov 14. Epub 2017 Nov 14.
    Unidad de Endocrinología Pediátrica, Hospital Materno Infantil Carlos Haya, Málaga, España; Grupo IBIMA. Electronic address:
    Introduction: The representation of Spain in European epidemiological studies on diabetes is limited, with only one centre in the Hvidoere study and another in the SWEET study. No Spanish studies have been published that combine epidemiological data and care resources. The aim of this study was to determine the epidemiological data, care resources, and use of new technologies in all Andalusian hospitals that care for children with Diabetes Mellitus type 1 (DM1) under 14 years. Read More

    [Visual Analysis of Retinal OCT Data].
    Klin Monbl Augenheilkd 2017 Nov 16. Epub 2017 Nov 16.
    Institut für Informatik, Universität Rostock, Rostock.
    Optical coherence tomography (OCT) enables noninvasive high-resolution 3D imaging of the human retina, and thus plays a fundamental role in ophthalmology. Via OCT examination, even subtle retinal changes can be captured, which occur in very early stages of different diseases (e.g. Read More

    Socioeconomic Deprivation, Household Education, and Employment are Associated With Increased Hospital Admissions and Poor Glycemic Control in Children With Type 1 Diabetes Mellitus.
    Rev Diabet Stud 2017 Summer-Fall;14(2-3):295-300. Epub 2017 Oct 10.
    Department of Paediatrics, Southport and Ormskirk NHS Trust, Wigan Road, Ormskirk, L39 2AZ. United Kingdom.
    Background: Socioeconomic deprivation, obesity, and emotional discomfort are important determinants of health inequalities and poor glycemic control in children and young people with type 1 diabetes mellitus (T1D).

    Objectives: The aims of this study were to evaluate the incidence of hospital admissions of T1D children in relation to socioeconomic deprivation, and to determine the effects of social deprivation, body mass index (BMI), and patient-reported emotional well-being on glycemic control.

    Methods: All hospital admissions of T1D patients aged 1-18 years were identified during 2007 and 2012. Read More

    Translation and validation of Pediatric Quality of Life Inventory™ 3.0 Diabetes Module (PedsQL™ 3.0 Diabetes Module) in Brazil-Portuguese language.
    J Pediatr (Rio J) 2017 Nov 13. Epub 2017 Nov 13.
    Universidade de São Paulo (USP), Faculdade de Medicina, São Paulo, SP, Brazil; Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP, Brazil.
    Objective: The aim of the present study was to create a translated version of the Pediatric Quality of Life Inventory™ 3.0 Diabetes Module (PedsQL™ 3.0 Diabetes Module) in Brazilian Portuguese that was conceptually equivalent to the original American English version and to linguistically validate it in a Brazilian pediatric population with type 1 diabetes mellitus and their parents or caregivers. Read More

    Potential approaches to prevent hypoglycemia-associated autonomic failure.
    J Investig Med 2017 Nov 14. Epub 2017 Nov 14.
    Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA.
    Clear health benefits are associated with intensive glucose control in type 1 diabetes mellitus (T1DM). However, maintaining near-normal glycemia remains an elusive goal for many patients, in large part owing to the risk of severe hypoglycemia. In fact, recurrent episodes of hypoglycemia lead to 'hypoglycemia-associated autonomic failure' (HAAF), characterized by defective counter-regulatory responses to hypoglycemia. Read More

    Islet transplantation as safe and efficacious method to restore glycemic control and to avoid severe hypoglycemia after donor organ failure in pancreas transplantation.
    Clin Transplant 2017 Nov 15. Epub 2017 Nov 15.
    Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Zurich, Switzerland.
    The aim of this study was to assess safety and efficacy of islet transplantation after initial pancreas transplantation with subsequent organ failure. Patients undergoing islet transplantation at our institution after pancreas organ failure were compared to a control group of patients with pancreas graft failure, but without islet transplantation and to a group receiving pancreas re-transplantation. 10 patients underwent islet transplantation after initial pancreas transplantation failed and were followed for a median of 51 months. Read More

    The effect of peer support in adults with insulin pump-treated type 1 diabetes: a pilot study of a flexible and participatory intervention.
    Patient Prefer Adherence 2017 2;11:1879-1890. Epub 2017 Nov 2.
    Diabetes Management Research, Steno Diabetes Center Copenhagen, Gentofte.
    Aim: The aim of this study was to explore the effects of a flexible and participatory peer support intervention in a clinical setting for adults with type 1 diabetes treated with an insulin pump, focusing on enhancing diabetes-specific social capital. The key questions were as follows: 1) what effects are appropriate to expect, according to participants? and 2) to what extent did these effects occur?

    Methods: Two peer support intervention programs were conducted in a diabetes specialist clinic (N=30). A participatory and adaptable approach allowed flexibility in the content of peer support meetings, which were facilitated by a diabetes nurse. Read More

    Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors.
    Biomed Pharmacother 2017 Nov 7;97:919-927. Epub 2017 Nov 7.
    Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India. Electronic address:
    Estrogen is known to exhibit cardioprotective and antihyperlipidemic action. Valproic acid has been shown to upregulate estrogen receptors (ERs) in breast and prostate cancer tissues. No pharmacological evaluations for magnesium valproate (MgV) so far have been done for diabetic cadio-lipidemic complications. Read More

    Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review.
    Hum Reprod Update 2017 Nov 10:1-20. Epub 2017 Nov 10.
    Clinical Research Unit, Centre of Internal Medicine, Justus-Liebig-University, Giessen, Germany.
    Background: Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees of inadequate insulin secretion resulting in diabetes and related comorbidities. To date several reviews have addressed the issue of diabetes-related male infertility but most have focused on how metabolic syndrome causes the decline in male fertility. However, a comprehensive overview as to how diabetes-induced hyperglycemia impairs male fertility is missing. Read More

    Enhanced effect of human mesenchymal stem cells expressing human TNF-αR-Fc and HO-1 gene on porcine islet xenotransplantation in humanized mice.
    Xenotransplantation 2017 Nov 14. Epub 2017 Nov 14.
    Transplantation Research Center, Samsung Biomedical Research Institute, Seoul, Korea.
    Background: Porcine islet xenotransplantation is considered an attractive alternative treatment for type 1 diabetes mellitus. However, it is largely limited because of initial rejection due to Instant Blood-Mediated Inflammatory Reaction (IBMIR), oxidative stress, and inflammatory responses. Recently, soluble tumor necrosis factor-ɑ receptor type I (sTNF-αR) and heme oxygenase (HO)-1 genes (HO-1/sTNF-αR) have been shown to improve the viability and functionality of porcine islets after transplantation. Read More

    Levels of adhesion molecules in peripheral blood correlat with stages of diabetic retinopathy and may serve as bio markers for microvascular complications.
    Cytokine 2017 Nov 10. Epub 2017 Nov 10.
    Department of Ophthalmology, Baruch Padeh Poria Medical Center, Faculty of Medicine in the Galilee Bar Ilan University, Galilee 15208, Israel.
    Background: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy.

    Methods: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus. Read More

    Evidence for congruent impairment in micro and macrovascular function in type 1 diabetes.
    PLoS One 2017 13;12(11):e0187525. Epub 2017 Nov 13.
    Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, Catanzaro, Italy.
    Diabetes affects large and small vessels through mechanisms only partially known. In the present study, we evaluated the function of capillaries and large arteries in subjects with type 1 diabetes mellitus (T1DM) to study the effect of chronic hyperglycemia in the absence of other cardiovascular risk factors. Twenty-five subjects with T1DM and 12 healthy age-matched controls were enrolled. Read More

    Associations between birthweight, gestational age at birth and subsequent type 1 diabetes in children under 12: a retrospective cohort study in England, 1998-2012.
    Diabetologia 2017 Nov 11. Epub 2017 Nov 11.
    Unit of Health-Care Epidemiology, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
    Aims/hypothesis: With genetics thought to explain only 40-50% of the total risk of type 1 diabetes, environmental risk factors in early life have been proposed. Previous findings from studies of type 1 diabetes incidence by birthweight and gestational age at birth have been inconsistent. This study aimed to investigate the relationships between birthweight, gestational age at birth and subsequent type 1 diabetes in England. Read More

    Subclinical First Trimester Renal Abnormalities Are Associated With Preeclampsia in Normoalbuminuric Women With Type 1 Diabetes.
    Diabetes Care 2017 Nov 9. Epub 2017 Nov 9.
    Centre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland, U.K.
    Objective: This study was conducted to determine the utility of tubular (urinary/plasma neutrophil gelatinase-associated lipocalin [NGAL] and urinary kidney injury molecule 1 [KIM-1]) and glomerular (estimated glomerular filtration rate [eGFR]) biomarkers in predicting preeclampsia (PE) in pregnant women with type 1 diabetes mellitus (T1DM) who were free of microalbuminuria and hypertension at the first trimester.

    Research Design And Methods: This was a prospective study of T1DM pregnancy. Maternal urinary and plasma NGAL urinary KIM-1 (ELISA of frozen samples), and eGFR (Chronic Kidney Disease Epidemiology Collaboration equation) were determined at three study visits (V1: 12. Read More

    Fetal overgrowth in women with type 1 and type 2 diabetes mellitus.
    PLoS One 2017 9;12(11):e0187917. Epub 2017 Nov 9.
    Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö, Sweden.
    Objectives: Despite improved glycemic control, the rate of large-for-gestational-age (LGA) infants remains high in pregnancies complicated by diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Poor glycemic control, obesity, and excessive gestational weight gain are the main risk factors. The aim of this study was to determine the relative contribution of these risk factors for LGA in women with T1DM and T2DM, after controlling for important confounders such as age, smoking, and parity. Read More

    Route to improving Type 1 diabetes mellitus glycaemic outcomes: real-world evidence taken from the National Diabetes Audit.
    Diabet Med 2017 Nov 9. Epub 2017 Nov 9.
    National Diabetes Audit.
    Aim: To use general practice-level data for England, available through the National Diabetes Audit, and primary care prescribing data to identify prescription treatment factors associated with variations in achieved glucose control (HbA1c ).

    Methods: General practice-level National Diabetes Audit data on Type 1 diabetes, including details of population characteristics, services, proportion of people achieving target glycaemic control [HbA1c ≤58 mmol/mol (7.5%)] and proportion of people at high glycaemic risk [HbA1c >86 mmol/ml (10%)], were linked to 2013-2016 primary care diabetes prescribing data on insulin types and blood glucose monitoring for all people with diabetes. Read More

    Sensor-augmented CSII therapy with predictive low-glucose suspend following total pancreatectomy.
    Endocrinol Diabetes Metab Case Rep 2017 28;2017. Epub 2017 Oct 28.
    Department of Endocrinology, Royal North Shore Hospital, Sydney Australia.
    Pancreatogenic diabetes is characterised by recurrent severe hypoglycaemia due to changes in both endocrine and exocrine functions. There are no guidelines to manage these individuals. Herein, we describe the post-operative management of two people who developed pancreatogenic diabetes following total pancreatectomy for neuroendocrine malignancy. Read More

    Route to improving Type 1 diabetes mellitus glycaemic outcomes: real-world evidence taken from the National Diabetes Audit.
    Diabet Med 2017 Nov 8. Epub 2017 Nov 8.
    Consultant Diabetologist, Diabetes Resource Centre, Harrogate District Hospital, Harrogate, UK.
    The National Diabetes Audit (NDA) has helped to highlight the disparity in glycaemic outcomes between those with Type 1 and those with Type 2 diabetes. Whilst ~70% of those with Type 2 diabetes achieve an HbA1c concentration <58 mmol/mol (7.5%), only 30% of those with Type 1 diabetes do so. Read More

    Fluctuations in the incidence of type 1 diabetes in the United States from 2001 to 2015: a longitudinal study.
    BMC Med 2017 Nov 8;15(1):199. Epub 2017 Nov 8.
    Institute of Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.
    Background: While the United States has the largest number of children with type 1 diabetes mellitus, less is known regarding adult-onset disease. The present study utilizes nationwide data to compare the incidence of type 1 diabetes in youth (0-19 years) to that of adults (20-64 years).

    Methods: In this longitudinal study, the Clinformatics® Data Mart Database was used, which contains information from 61 million commercially insured Americans (years 2001-2015). Read More

    High Neonatal Blood Iron Content Is Associated with the Risk of Childhood Type 1 Diabetes Mellitus.
    Nutrients 2017 Nov 6;9(11). Epub 2017 Nov 6.
    Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Paediatrics, Herlev University Hospital, 2730 Herlev, Denmark.
    (1) Background: Iron requirement increases during pregnancy and iron supplementation is therefore recommended in many countries. However, excessive iron intake may lead to destruction of pancreatic β-cells. Therefore, we aim to test if higher neonatal iron content in blood is associated with the risk of developing type 1 diabetes mellitus (T1D) in childhood; (2) Methods: A case-control study was conducted, including 199 children diagnosed with T1D before the age of 16 years from 1991 to 2005 and 199 controls matched on date of birth. Read More

    Moderate-intensity 4mT static magnetic fields prevent bone architectural deterioration and strength reduction by stimulating bone formation in streptozotocin-treated diabetic rats.
    Bone 2017 Oct 27;107:36-44. Epub 2017 Oct 27.
    Department of Orthopedics, The Affiliated Hospital of Air Force Aviation Medicine Research Institute, Beijing 100089, China. Electronic address:
    Type 1 diabetes mellitus (T1DM) has been associated with deterioration of bone microarchitecture and strength, resulting in increased fracture risk. Substantial studies have revealed the capacity of moderate-intensity static magnetic fields (SMF) on promoting osteoblastogenesis in vitro and stimulating bone growth and bone regeneration in vivo, whereas it is unknown whether SMF can resist T1DM-associated osteopenia/osteoporosis. We herein investigated the potential effects of whole-body SMF exposure with 4mT on bone loss in streptozotocin-induced T1DM rats. Read More

    Circulating Endothelial Progenitor Cells in Type 1 Diabetic Patients: Relation with Patients' Age and Disease Duration.
    Front Endocrinol (Lausanne) 2017 23;8:278. Epub 2017 Oct 23.
    Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
    Objectives: Circulating endothelial progenitor cells (cEPCs) have been reported to be dysfunctional in diabetes mellitus (DM) patients, accounting for the vascular damage and the ensuing high risk for cardiovascular disease (CVD) characteristic of this disease. The aim of the present study was to evaluate the number of circulating cEPCs in type 1 DM (T1DM) patients, without clinical vascular damage, of different ages and with different disease duration.

    Methods: An observational, clinical-based prospective study was performed on T1DM patients enrolled in two clinical centers. Read More

    The rs2292239 polymorphism in ERBB3 gene is associated with risk for type 1 diabetes mellitus in a Brazilian population.
    Gene 2017 Nov 3. Epub 2017 Nov 3.
    Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil; Post-graduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:
    The Erb-b2 receptor tyrosine kinase 3 (ERBB3) belongs to a family of epidermal growth factor receptors of protein tyrosine kinases, and regulates cell survival, differentiation and proliferation in several cell types. Previous studies have suggested that ERBB3 contributes to T1DM pathogenesis by modulating antigen presenting cell function, autoimmunity and cytokine-induced beta-cell apoptosis. Accordingly, some genome-wide association studies identified ERBB3 gene as a susceptibility locus for T1DM, with the strongest association signal being observed for the rs2292239 single nucleotide polymorphism (SNP) in intron 7 of the gene. Read More

    Physical activity and autoimmune diseases: Get moving and manage the disease.
    Autoimmun Rev 2017 Nov 3. Epub 2017 Nov 3.
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:
    Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous group of chronic diseases, which occur secondary to loss of self-antigen tolerance. Read More

    Measuring Self-Efficacy in the Context of Pediatric Diabetes Management: Psychometric Properties of the Self-Efficacy for Diabetes Scale.
    J Pediatr Psychol 2017 Jul 4. Epub 2017 Jul 4.
    Department of Pediatrics, University of Kansas Medical Center.
    Objective: The Self-Efficacy for Diabetes Scale (SED) is a widely used measure of diabetes-specific self-efficacy with three subscales: diabetes-specific self-efficacy (SED-D), medical self-efficacy (SED-M), and general self-efficacy (SED-G). The present study examined the factor structure and construct validity of the SED in 116 youth, aged 10-16 years (13.60 ± 1. Read More

    Acute-onset type 1 diabetes mellitus caused by nivolumab in a patient with advanced pulmonary adenocarcinoma.
    J Diabetes Investig 2017 Nov;8(6):798-799
    Department of Endocrinology and Metabolism, Tsukuba University Hospital Mito Clinical Education and Training Center, Mito Kyodo General Hospital, Mito, Ibaraki, Japan.
    A case of acute-onset type 1 diabetes mellitus concomitant with pneumonitis and vitiligo is described. Read More

    A Danish version of self-efficacy in diabetes self-management: A valid and reliable questionnaire affected by age and sex.
    Pediatr Diabetes 2017 Nov 2. Epub 2017 Nov 2.
    Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark.
    Background: Managing the chronic illness type 1 diabetes (T1D) is extremely demanding, especially during adolescence. Self-efficacy is belief in one's own capabilities and this is crucial for diabetes management. Having a valid method for measuring self-efficacy is important. Read More

    Reprioritizing life: a conceptual model of how women with type 1 diabetes deal with main concerns in early motherhood.
    Int J Qual Stud Health Well-being 2017 ;12(sup2):1394147
    b Centre for Person-Centered Care (GPCC) , Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
    Purpose: Becoming a mother is related to increased demands for women with type 1 diabetes mellitus, and more research is needed to identify their needs for support in everyday living. Thus, the aim of this study was to explore the main concerns in daily life in early motherhood for women with type 1 diabetes and how they deal with these concerns.

    Method: A grounded theory study was conducted in which 14 women with type 1 diabetes were interviewed individually 7 to 17 months after childbirth. Read More

    ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes.
    N Engl J Med 2017 11;377(18):1733-1745
    From the Department of Paediatrics (M.L.M., D.B.D.) and the Wellcome Trust-Medical Research Council Institute of Metabolic Science (D.B.D.), University of Cambridge, and the Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital (S.B., S.D.), Cambridge, the National Centre for Cardiovascular Prevention and Outcomes, University College London (S.T.C., J.D.), and the WellChild Laboratory, Evelina London Children's Hospital, St. Thomas' Hospital (R.N.D.), London, the Institute of Cellular Medicine (Diabetes), Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne (S.M.M.), and the Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford (H.A.W.N.) - all in the United Kingdom; the Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto (D.D., F.H.M.); and the Institute of Endocrinology and Diabetes, Children's Hospital at Westmead and University of Sydney, Sydney (K.C.D.), and the Telethon Kids Institute, University of Western Australia, Perth (T.W.J.) - both in Australia.
    Background: Among adolescents with type 1 diabetes, rapid increases in albumin excretion during puberty precede the development of microalbuminuria and macroalbuminuria, long-term risk factors for renal and cardiovascular disease. We hypothesized that adolescents with high levels of albumin excretion might benefit from angiotensin-converting-enzyme (ACE) inhibitors and statins, drugs that have not been fully evaluated in adolescents.

    Methods: We screened 4407 adolescents with type 1 diabetes between the ages of 10 and 16 years of age and identified 1287 with values in the upper third of the albumin-to-creatinine ratios; 443 were randomly assigned in a placebo-controlled trial of an ACE inhibitor and a statin with the use of a 2-by-2 factorial design minimizing differences in baseline characteristics such as age, sex, and duration of diabetes. Read More

    Primary adrenal insufficiency in adult population: a Portuguese multicentre study by the Adrenal Tumours Study Group.
    Endocr Connect 2017 Oct 31. Epub 2017 Oct 31.
    M Ferreira, Endocrinology, Hospital de Braga, Braga, Portugal.
    Introduction: Primary adrenal insufficiency (PAI) is a rare but severe and potentially life-threatening condition. No previous studies have characterized Portuguese patients with PAI.

    Aims: To characterize the clinical presentation, diagnostic workup, treatment and follow-up of Portuguese patients with confirmed PAI. Read More

    Time trends, regional variability and seasonality regarding the incidence of type 1 diabetes mellitus in Romanian children aged 0-14 years, between 1996 and 2015.
    J Clin Res Pediatr Endocrinol 2017 Oct 30. Epub 2017 Oct 30.
    Objective: The incidence of type 1 diabetes mellitus in children is highly variable in the world. The aim of our study was to analyze the evolution of the incidence of childhood type 1 diabetes in Romania between 1996 and 2015, and to search for differences amongst age groups, gender, geographic regions and month of diagnosis.

    Methods: All new cases of type 1 diabetes, aged <15 years, diagnosed by two independent sources, were included in the study. Read More

    Review of 2017 Diabetes Standards of Care.
    Nurs Clin North Am 2017 Dec;52(4):621-663
    North Texas Endocrine Center, 9301 North Central Expressway, Tower II, Suite 570, Dallas, TX 75231, USA. Electronic address:
    Diabetes is a complex medical condition that requires evidence-based care. This article discusses the current diabetes screening, diagnostic criteria, and treatment recommendations for patients with type 1 diabetes, type 2 diabetes, gestational diabetes, and prediabetes. Read More

    Management of Diabetes in Children and Adolescents.
    Nurs Clin North Am 2017 Dec 5;52(4):589-603. Epub 2017 Oct 5.
    Department of Endocrine Neoplasia and Hormonal Disorders, MD Anderson Cancer Center, 1515 Holcomb Boulevard, Houston, TX 77030, USA. Electronic address:
    Diabetes is a common chronic illness in children and adolescents. This article will discuss the prevalence, diagnostic criteria, types, treatment, and transition of care into adulthood. Read More

    Insulin Therapy: The Old, the New and the Novel-An Overview.
    Nurs Clin North Am 2017 Dec 5;52(4):539-552. Epub 2017 Oct 5.
    University of Nevada, Reno School of Medicine, Reno, NV 89557, USA. Electronic address:
    Since its development, insulin therapy has been a mainstay in the arsenal of every practitioner battling against diabetes. For patients with type 1 diabetes mellitus, insulin is essential for survival, and for those with type 2 diabetes mellitus, as the disease progresses, it may become a necessary addition to treatment. The goal of this article is to discuss insulin therapies that are currently available for use in the management of diabetes, from the old to the new and novel, and briefly discuss insulin use in special populations. Read More

    Management of Type 1 Diabetes.
    Nurs Clin North Am 2017 Dec 5;52(4):499-511. Epub 2017 Oct 5.
    Department of Endocrine Neoplasia and Hormonal Disorders, UT MD Anderson Cancer Center, 1400 Pressler Street, Unit 1461, Houston, TX 77030, USA. Electronic address:
    Comprehensive type 1 diabetes management requires understanding of the pathophysiology of disease and the ability to contrast this process with type 2 diabetes. Nurses are often the first contact with patients and must be aware of the advancements in detection, therapies, and signs of complications in these patients. Individuals with type 1 diabetes are at high risk for glycemic complications caused by potentially preventable errors in medication administration, which can be mitigated with appropriate education. Read More

    Thioredoxin-1 Overexpression in the Ventromedial Nucleus of the Hypothalamus (VMH) Preserves the Counterregulatory Response to Hypoglycemia During Type 1 Diabetes Mellitus in Male Rats.
    Diabetes 2017 Oct 27. Epub 2017 Oct 27.
    Department of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark NJ 07103
    We previously showed that the glutathione precursor, N-acetylcysteine (NAC), prevented hypoglycemia-associated autonomic failure (HAAF) and impaired activation of ventromedial hypothalamus (VMH) glucose-inhibited (GI) neurons by low glucose after recurrent hypoglycemia (RH) in non-diabetic rats. However, NAC does not normalize glucose sensing by VMH GI neurons when RH occurs during diabetes. We hypothesized that recruiting the thioredoxin (Trx) antioxidant defense system would prevent HAAF and normalize glucose sensing after RH in diabetes. Read More

    Fifteen-minute consultation: diabulimia and disordered eating in childhood diabetes.
    Arch Dis Child Educ Pract Ed 2017 Oct 27. Epub 2017 Oct 27.
    Department of Child Health, University Hospital of Wales, Cardiff, UK.
    Type 1 diabetes mellitus (T1DM) is a common chronic disease in children and young people. Living with diabetes can pose many challenges both medical and psychological. Disordered eating behaviours, intentional insulin omission and recognised eating disorders are common among young people with diabetes and are associated with increased risk of short-term and long-term complications and death. Read More

    Clinical Tolerogenic Dendritic Cells: Exploring Therapeutic Impact on Human Autoimmune Disease.
    Front Immunol 2017 12;8:1279. Epub 2017 Oct 12.
    Allegheny Health Network Institute of Cellular Therapeutics, Allegheny General Hospital, Pittsburgh, PA, United States.
    Tolerogenic dendritic cell (tDC)-based clinical trials for the treatment of autoimmune diseases are now a reality. Clinical trials are currently exploring the effectiveness of tDC to treat autoimmune diseases of type 1 diabetes mellitus, rheumatoid arthritis, multiple sclerosis (MS), and Crohn's disease. This review will address tDC employed in current clinical trials, focusing on cell characteristics, mechanisms of action, and clinical findings. Read More

    Evaluation of Coagulation Profile in Children with Type 1 Diabetes Mellitus Using Rotational Thromboelastometry.
    Indian J Hematol Blood Transfus 2017 Dec 28;33(4):574-580. Epub 2017 Feb 28.
    Department of Hematology and Oncology, Osmangazi University School of Medicine, Eskisehir, Turkey.
    The prothrombotic state in type 1 diabetes mellitus (T1DM) has been reported as a plausible cause of vascular complications. Rotational thromboelastometry (ROTEM) assay enables the global assessment of coagulation status. This study aimed to assess hypercoagulability in children with T1DM using ROTEM. Read More

    Previously unreported abnormalities in Wolfram Syndrome Type 2.
    Pediatr Endocrinol Diabetes Metab 2017 ;23(2):107-110
    Ph.D. candidate. Department of Molecular Biology. Centre INRS-Institut Armand-Frappier, Laval, Quebec, Canada.
    Wolfram syndrome (WFS) is a rare autosomal recessive disease with non-autoimmune childhood onset insulin dependent diabetes and optic atrophy. WFS type 2 (WFS2) differs from WFS type 1 (WFS1) with upper intestinal ulcers, bleeding tendency and the lack ofdiabetes insipidus. Li-fespan is short due to related comorbidities. Read More

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