74,931 results match your criteria Diabetes Mellitus Type 1


Ultrasonographic Evaluation of Glycemic Control Effect on Placental Vascularization in Pregnancy with Type 1 Diabetes Mellitus.

Exp Clin Endocrinol Diabetes 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary.

Aims: The aim of our study was to assess the effect of glycemic control on placental vascularization in pregnancies complicated by type 1 diabetes mellitus (T1DM) and to compare dataset of optimal/suboptimal glycemic control to normal placental 3-dimensional power Doppler (3-DPD) indices in 2 and 3 trimester.

Methods: Placental vascularization of pregnant women was prospectively evaluated by 3-DPD ((vascularization-index (VI); flow-index (FI); vascularization-flow-index (VFI)) ultrasound technique. The normal pregnancies (n=214) were compared to those complicated by T1DM (n=53) with optimal (HbA1C≤6%;≤ 42 mmol/mol) and suboptimal (HbA1C>6%;>42 mmol/mol) glycemic control. Read More

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http://dx.doi.org/10.1055/a-0824-6362DOI Listing
January 2019

Does Sleep Duration, Napping, and Social Jetlag Predict Hemoglobin A1c among College Students with Type 1 Diabetes Mellitus?

Diabetes Res Clin Pract 2019 Jan 11. Epub 2019 Jan 11.

University of Delaware, Tower at STAR, 5th Floor, 100 Discovery Blvd, Newark, DE 19713. Electronic address:

Aims: The first aim examined the relationship between sleep behaviors (duration, napping, and social jetlag) and hemoglobin A1c (HbA1c) among emerging young adults (EYAs) with T1DM between 18-25 years old, who are living on a college campus. The second aim characterized the gender differences in glucose management, sleep behaviors, caffeine intake, and nighttime technology.

Methods: A cross-sectional study of eligible participants used a convenience sample of eligible participants. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.007DOI Listing
January 2019

Inflammatory bowel diseases and primary immunodeficiency diseases.

Immunol Med 2019 Jan 11:1-8. Epub 2019 Jan 11.

a Department of Child Health and Development, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.

Recent advances in molecular biology have provided important insights into the genetic background of various inflammatory diseases. In particular, genome-wide association studies of inflammatory diseases have revealed genetic loci that play critical roles in the pathology of inflammation. Whole-exome and whole-genome sequencing analyses have also identified more than 300 causative genes for primary immunodeficiency diseases (PIDs). Read More

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https://www.tandfonline.com/doi/full/10.1080/25785826.2018.1
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http://dx.doi.org/10.1080/25785826.2018.1556025DOI Listing
January 2019
1 Read

Impact of technology-based interventions for children and young people with type 1 diabetes on key diabetes self-management behaviours and prerequisites: a systematic review.

BMC Endocr Disord 2019 Jan 10;19(1). Epub 2019 Jan 10.

University of Nottingham, School of Health Sciences, Nottingham, UK.

Background: The role of technology in the self-management of type 1 diabetes mellitus (T1DM) among children and young people is not well understood. Interventions should aim to improve key diabetes self-management behaviours (self-management of blood glucose, insulin administration, physical activity and dietary behaviours) and prerequisites (psychological outcomes and HbA1c) highlighted in the UK guidelines of the National Institute for Health and Care Excellence (NICE) for management of T1DM. The purpose was to identify evidence to assess the effectiveness of technological tools in promoting aspects of these guidelines amongst children and young people. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-018-0331-6DOI Listing
January 2019
1 Read

Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice.

J Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

M Yamamoto, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

The transcription factor Nrf2 (NF-E2-related factor 2) plays a critical role in oxidative stress responses. While activation of Nrf2 signaling is known to exert anti-inflammatory effects, Nrf2 function in inflammation-mediated autoimmune disorders, such as type 1 diabetes, is not well established. To address the roles of Nrf2 in protection against autoreactive T-cell-induced type 1 diabetes, we used non-obese diabetic (NOD) mice, a polygenic model of human type 1 diabetes, to generate a genetic model that allowed us to assess the contribution of Nrf2 activation to preventing and/or treating type 1 diabetes. Read More

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https://joe.bioscientifica.com/view/journals/joe/aop/joe-18-
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http://dx.doi.org/10.1530/JOE-18-0355DOI Listing
January 2019
1 Read

The characteristics of blood glucose fluctuations in patients with fulminant type 1 diabetes mellitus in the stable stage.

Arch Endocrinol Metab 2018 ;62(6):585-590

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: The aim was to characterize blood glucose fluctuations in patients with fulminant type 1 diabetes (FT1DM) at the stable stage using continuous blood glucose monitoring systems (CGMSs).

Subjects And Methods: Ten patients with FT1DM and 20 patients with classic type 1 diabetes mellitus (T1DM) (the control group) were monitored using CGMSs for 72 hours.

Results: The CGMS data showed that the mean blood glucose (MBG), the standard deviation of the blood glucose (SDBG), the mean amplitude glycemic excursions (MAGE), the blood glucose areas and the percentages of blood glucose levels below 13. Read More

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http://dx.doi.org/10.20945/2359-3997000000082DOI Listing
January 2018
1 Read

Short-acting insulin analogues versus regular human insulin on postprandial glucose and hypoglycemia in type 1 diabetes mellitus: a systematic review and meta-analysis.

Diabetol Metab Syndr 2019 3;11. Epub 2019 Jan 3.

5Department of Internal Medicine, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Introduction: Strict glucose control using multiple doses of insulin is the standard treatment for type 1 diabetes mellitus (T1DM), but increased risk of hypoglycemia is a frequent drawback. Regular insulin in multiple doses is important for achieving strict glycemic control for T1DM, but short-acting insulin analogues may be better in reducing hypoglycemia and postprandial glucose levels.

Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effects of short-acting insulin analogues regular human insulin on hypoglycemia and postprandial glucose in patients with T1DM. Read More

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https://dmsjournal.biomedcentral.com/articles/10.1186/s13098
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http://dx.doi.org/10.1186/s13098-018-0397-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317184PMC
January 2019
2 Reads

Hyperglycemic status is associated with an elevated risk of osteoporotic fracture in community-dwelling elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) cohort study.

Bone 2019 Jan 5;121:100-106. Epub 2019 Jan 5.

Nara Medical University School of Medicine, 840 Shijocho, Kashihara, Nara 634-8521, Japan.

Purpose: Patients with type 2 diabetes mellitus have an increased fracture risk. However, population-based studies on the association between glycemic status and fracture risk are scarce, and none have targeted a Japanese population. In addition, patients in the lowest category of hemoglobin A1c (HbA1c) do not always show the lowest risk. Read More

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http://dx.doi.org/10.1016/j.bone.2019.01.005DOI Listing
January 2019

Exposing the Causal Effect of C-Reactive Protein on the Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study.

Front Genet 2018 20;9:657. Epub 2018 Dec 20.

Heilongjiang Provincial Hospital, Harbin, China.

As a biomarker of inflammation, C-reactive protein (CRP) has attracted much attention due to its role in the incidence of type 2 diabetes mellitus (T2DM). Prospective studies have observed a positive correlation between the level of serum CRP and the incidence of T2DM. Recently, studies have reported that drugs for curing T2DM can also decrease the level of serum CRP. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2018.00657
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http://dx.doi.org/10.3389/fgene.2018.00657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306438PMC
December 2018
2 Reads

Dietary macronutrients and fluid intakes in a sample of pregnant women with either gestational diabetes or type 1 diabetes mellitus, assessed in comparison with Polish nutritional guidelines.

Ginekol Pol 2018 ;89(12):659-666

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.

Objectives: Pregnancy is a critical period during which environmental factors such as nutrition can affect development. Maintaining proper nutrition becomes even more significant when pregnant women have diabetes. The aim of this study was to measure changes in energy and macronutrient intakes among pregnant women and patients diagnosed either with gestational diabetes mellitus (GDM) during pregnancy, or, type 1 diabetes mellitus (T1DM) before pregnancy, and to assess the pregnant women's dietary intakes in comparison with Polish Institute of Food and Nutrition nutritional guidelines. Read More

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http://dx.doi.org/10.5603/GP.a2018.0111DOI Listing
January 2018

Celiac disease among at-risk individuals in Saudi Arabia.

Saudi Med J 2019 Jan;40(1):9-18

Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To perform a meta-analysis for celiac diseases (CD) among at-risk populations in Kingdom of Saudi Arabia (KSA), as well as a comparison with our previously reported meta-analysis in the normal population.

Methods: In March 2018, at King Abdulaziz University,  Jeddah, KSA we commenced a retrospective comprehensive database and journal search for CD among at-risk populations in SA. Data from each of the relevant articles were analyzed using the  Statistical Package for Social Science Version 20 (Armonk, NY: IBM Corp. Read More

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http://dx.doi.org/10.15537/smj.2019.1.23892DOI Listing
January 2019
2 Reads

Disease-Modifying Therapies in Type 1 Diabetes: A Look into the Future of Diabetes Practice.

Drugs 2019 Jan 5. Epub 2019 Jan 5.

Benaroya Research Institute, 1201 Ninth Avenue, Seattle, WA, 98101, USA.

The novel understanding that the presence of multiple islet autoantibodies, indicating islet autoimmunity, inevitably leads to type 1 diabetes mellitus (T1DM) has necessitated the development of a new staging classification system for the condition. Coupled with an improved understanding of the disease course, the realization that T1DM appears to be more heterogeneous than previously thought has led to unique opportunities to develop more targeted therapies that may be applied even before the onset of dysglycemia or symptoms. To date, several therapies have been trialed to delay or halt disease progression in both presymptomatic and clinical T1DM, each demonstrating varying degrees of effectiveness, toxicity, and utility. Read More

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http://dx.doi.org/10.1007/s40265-018-1035-yDOI Listing
January 2019

The impact of autoimmune thyroiditis on skin microcirculation in children with non-complicated type 1 diabetes mellitus.

Microvasc Res 2019 Jan 3;123:68-73. Epub 2019 Jan 3.

Clinical Physiology Unit, Medical Simulation Centre, Medical University of Gdańsk, Ul. Dębowa 25, 80-204 Gdańsk, Poland.

Background: The impairment of endothelial function in type 1 diabetes mellitus (DM1) is considered as the basis of microvascular complications. In DM1 patients autoimmune thyroiditis is a frequent comorbidity which may be responsible for further deterioration of microcirculation function. In studies investigating the relationship between cardiovascular risk factors and microvascular function, skin microcirculation is widely used. Read More

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http://dx.doi.org/10.1016/j.mvr.2019.01.002DOI Listing
January 2019
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Pheochromocytoma presenting with severe hyperglycemia and metabolic acidosis following intra-articular glucocorticoid administration: a case report.

J Med Case Rep 2019 Jan 5;13(1). Epub 2019 Jan 5.

Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.

Background: There are several reports of pheochromocytoma crisis triggered by systemic glucocorticoid administration. However, pheochromocytoma crisis after intra-articular glucocorticoid administration has been rarely reported.

Case Presentation: A 45-year-old Japanese man presented to our hospital with a sudden, severe headache. Read More

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http://dx.doi.org/10.1186/s13256-018-1945-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320610PMC
January 2019
1 Read

Children's Age, Family Conflict, and Children's HbA1c: Are Girls and Boys Different?

South Med J 2019 Jan;112(1):16-20

From the Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health, Brownsville, and the Department of Pediatrics, Boonshoft School of Medicine, Wright State University, Dayton, Ohio.

Objective: This study examined the relation between children's sex, age, family conflict, and children's glycated hemoglobin A1c (HbA1c).

Methods: Parents of children with type 1 diabetes mellitus were recruited from the diabetes clinic of a midwestern children's hospital. The survey included demographics and the Diabetes Family Conflict Scale (DFCS). Read More

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http://dx.doi.org/10.14423/SMJ.0000000000000912DOI Listing
January 2019

Risk Factors for Early-Onset Ischemic Stroke: A Case-Control Study.

J Am Heart Assoc 2018 Nov;7(21):e009774

1 Clinical Neurosciences University of Helsinki and Department of Neurology, Helsinki University Hospital Helsinki Finland.

Background Recent studies have shown an increasing prevalence of vascular risk factors in young adults with ischemic stroke ( IS ). However, the strength of the association between all vascular risk factors and early-onset IS has not been fully established. Methods and Results We compared 961 patients with a first-ever IS at 25 to 49 years to 1403 frequency-matched stroke-free controls from a population-based cohort study ( FINRISK ). Read More

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http://dx.doi.org/10.1161/JAHA.118.009774DOI Listing
November 2018

Targeting Type 1 Diabetes: Selective Approaches for New Therapies.

Biochemistry 2019 Jan 4. Epub 2019 Jan 4.

The clinical onset of type 1 diabetes is characterized by the destruction of the insulin-producing β cells of the pancreas, and is caused by autoantigen-induced inflammation (insulitis) of the islets of Langerhans. The current standard of care for type 1 diabetes mellitus (T1DM) patients allows for management of the disease with exogenous insulin, but patients eventually succumb to many chronic complications such as limb amputation, blindness and kidney failure. New therapeutic approaches now on the horizon are looking beyond glycemic management and are evaluating new strategies from protecting and regenerating endogenous islets to treating the underlying autoimmunity through selective modulation of key immune cell populations. Read More

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http://dx.doi.org/10.1021/acs.biochem.8b01118DOI Listing
January 2019

Current Status of Stem Cell Treatment for Type I Diabetes Mellitus.

Tissue Eng Regen Med 2018 Dec 2;15(6):699-709. Epub 2018 Aug 2.

Department of Life Sciences (R&D), Datt Mediproducts Pvt. Ltd., Roz Ka Meo Industrial Area, Nuh, District Mewat, Haryana 122103 India.

Background: Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans. Read More

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http://dx.doi.org/10.1007/s13770-018-0143-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250656PMC
December 2018
0.613 Impact Factor

Diffusion-weighted magnetic resonance imaging in the pancreas of fulminant type 1 diabetes.

Diabetol Int 2018 Oct 12;9(4):257-265. Epub 2018 Apr 12.

19Department of Internal Medicine (I), Osaka Medical College, Takatsuki, Japan.

Abrupt disease onset and severe metabolic disorders are main characteristics of fulminant type 1 diabetes. Diffusion-weighted magnetic resonance imaging (DWI) is an imaging technique that reflects restricted diffusion in organs and can detect mononuclear cell infiltration into the pancreas at the onset of the disease. Fourteen patients with fulminant type 1 diabetes who underwent abdominal magnetic resonance imaging were recruited for the measurement of apparent diffusion coefficient (ADC) values of the pancreas that were compared with those of 21 non-diabetic controls. Read More

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http://link.springer.com/10.1007/s13340-018-0355-1
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http://dx.doi.org/10.1007/s13340-018-0355-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224878PMC
October 2018
1 Read

Diabetes mellitus and thyroid diseases.

Authors:
Masahiro Nishi

Diabetol Int 2018 May 9;9(2):108-112. Epub 2018 Mar 9.

Division of Clinical Nutrition and Metabolism, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-8509 Japan.

Both diabetes mellitus and thyroid diseases are very common in the fields of endocrinology and metabolism. Coexistence of diabetes mellitus and thyroid diseases are frequently experienced. However, higher prevalence of thyroid dysfunction in both type 1 and type 2 diabetes compared with non-diabetics have been reported. Read More

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http://dx.doi.org/10.1007/s13340-018-0352-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224947PMC

Diabetic nephropathy in the elderly – clinical practice

Rocz Panstw Zakl Hig 2018 ;69(4):327-334

Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego 82/84, 60-569 Poznan, Poland

Common health problems of the elderly in the near future will become even more common with aging of the population and longer average life expectancy. The elderly tend to have multiple disorders at one time, some of which may aggravate the course of others. One of the most common diseases, diabetes – “the epidemics of XXI century”, treatment of which costs approximately 11% of world health care budget – is the leading reason of chronic kidney disease and end-stage renal disease. Read More

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http://dx.doi.org/10.32394/rpzh.2018.0037DOI Listing
January 2018

Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study.

J Gastroenterol Hepatol 2019 Jan 1. Epub 2019 Jan 1.

Department of Diabetes and Endocrinology.

Aims: To assess the prevalence and characteristics of CD in all patients with Type 1 diabetes mellitus (T1DM) attending a tertiary adult diabetes clinic in Durban, South Africa.

Methods: This was a cross-sectional observational study which screened 202 patients; of these 56.4% were African (black), 31. Read More

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http://doi.wiley.com/10.1111/jgh.14596
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http://dx.doi.org/10.1111/jgh.14596DOI Listing
January 2019
5 Reads

Epilepsy in children with type 1 diabetes mellitus: Pathophysiological basis and clinical hallmarks.

Eur J Paediatr Neurol 2018 Dec 21. Epub 2018 Dec 21.

Pediatric Diabetology Unit, Department of Maternal and Infantile Health, Sapienza University of Rome, Italy.

We provide an overview on the current knowledge about the association between epilepsy and type 1 diabetes mellitus (T1DM). People with T1DM have a 2-6-fold higher risk of epilepsy than the general population. The onset of T1DM anticipates the onset of epilepsy by a mean period between 1,5 and 2,8 years. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.006DOI Listing
December 2018

Prenatal Exercise and Pre-gestational Diseases: A Systematic Review and Meta-analysis.

J Obstet Gynaecol Can 2018 Dec 28. Epub 2018 Dec 28.

Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB; Women and Children's Health Research Institute, University of Alberta, Edmonton, AB; Alberta Diabetes Institute, University of Alberta, Edmonton, AB. Electronic address:

Objective: This study sought to examine the effect of prenatal exercise on birth outcomes in women with pre-gestational diseases, including chronic hypertension, type 1 diabetes, and type 2 diabetes.

Methods: A structured search of online databases up to June 8, 2018 was conducted. Studies of all designs and languages were included if they contained information on the population (pregnant women with pre-gestational diseases), intervention (subjective or objective measures of frequency, intensity, duration, volume, or type of exercise), comparator (no exercise or different frequency, intensity, duration, volume, or type of exercise), and outcome (birth weight, macrosomia [birth weight >4000 g], large for gestational age (LGA) low birth weight [<2500 g], small for gestational age (SGA) [<10th percentile], Apgar score, preterm birth [<37 weeks], CS, preeclampsia, and glycemic control). Read More

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http://dx.doi.org/10.1016/j.jogc.2018.10.007DOI Listing
December 2018
1 Read

Stem cell therapy for patients with diabetes: a systematic review and meta-analysis of metabolomics-based risks and benefits.

Stem Cell Investig 2018 14;5:40. Epub 2018 Nov 14.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: There is a general agreement that to ensure promising results of stem cell therapy in patients with diabetes, one must first understand its risks and benefits; thus, if the risk is sufficiently low along with many benefits, it can lead to developing a novel therapeutic approach based on sound science.

Methods: A systematic review and meta-analysis was performed using all available clinical trials to determine the benefits and risks associated with stem cell therapy in patients with diabetes (both T1DM and T2DM). An extensive search was conducted across several databases using all MeSH words regarding stem cell therapy and diabetes. Read More

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http://dx.doi.org/10.21037/sci.2018.11.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286886PMC
November 2018

Circulating microRNAs as biomarkers for diabetic neuropathy: A novel approach.

World J Exp Med 2018 Nov 30;8(3):18-23. Epub 2018 Nov 30.

1 Department of Internal Medicine and Diabetes Center, Tzaneio General Hospital of Piraeus, Athens 18536, Greece.

Oxidative stress stemming from tissue exposure to constant hyperglycemia is one of the major pathogenetic pathways of diabetic macro- and microvascular complications. Diabetic polyneuropathy, commonly manifesting as distal, symmetrical sensorimotor polyneuropathy, is characterized by progressive severity of symptoms, with rates analogous to the quality of glycemic control achieved by the patients and physicians. Palliative care with analgesics and aggressive glycemic control often improve quality of life in the absence of causative treatment. Read More

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http://www.wjgnet.com/2220-315X/full/v8/i3/18.htm
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http://dx.doi.org/10.5493/wjem.v8.i3.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305524PMC
November 2018
2 Reads

Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes.

Fetal Pediatr Pathol 2018 Dec 27:1-9. Epub 2018 Dec 27.

a Department of Virology , Faculty of Medicine, Iran University of Medical Sciences , Tehran , The Islamic Republic of Iran.

Background: Some studies implicate rotavirus infection as a trigger for the development of type 1 diabetes mellitus (T1DM) in children, however findings are controversial.

Objectives: We investigated the link between rotavirus infection and autoantibodies against islet antigens and T1DM in children.

Methods: Serum samples from 80 new-onset diabetic and 80 nondiabetic children were screened for anti-rotavirus IgG, anti-GAD65 and anti-IA-2 autoantibodies using ELISA kits. Read More

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http://dx.doi.org/10.1080/15513815.2018.1547338DOI Listing
December 2018

Role of vitamin C in diabetic ketoacidosis: Is it ready for prime time?

World J Diabetes 2018 Dec;9(12):206-208

Acute and Continuing Care, The University of Texas Health Science Center at Houston, Houston, TX 77030, United States.

Diabetic ketoacidosis (DKA) is life-threatening acute metabolic complication of diabetes mellitus (DM) that is characterized by acidosis, ketosis, and hyperglycemia, currently affecting mostly patients under 30 years of age with diabetes mellitus type 1. In both, DM and DKA, a pro-inflammatory state exists. This clinical entity occurs as a result of hyperglycemia-induced disturbances, resulting in an increased oxidative metabolism. Read More

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http://www.wjgnet.com/1948-9358/full/v9/i12/206.htm
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http://dx.doi.org/10.4239/wjd.v9.i12.206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304299PMC
December 2018
3 Reads

Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis.

Lipids Health Dis 2018 Dec 26;17(1):293. Epub 2018 Dec 26.

Department of Endocrinology, Shenzhen Hospital, Southern Medical University, No. 1333, New Lake Road, Baoan District, Shenzhen, 518000, Guangdong, China.

Background: Inflammation may be a key pathophysiological mechanism in diabetic nephropathy (DN). Intercellular adhesion molecule 1 (ICAM1) is an acute phase marker of inflammation. ICAM1 rs5498 has been reported to be associated with the risk of DN. Read More

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http://dx.doi.org/10.1186/s12944-018-0922-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307272PMC
December 2018

Immunomodulatory Effect of Vitamin D and Its Potential Role in the Prevention and Treatment of Type 1 Diabetes Mellitus-A Narrative Review.

Molecules 2018 Dec 24;24(1). Epub 2018 Dec 24.

Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, ul. Chełmońskiego 37, 51-630 Wrocław, Poland.

Type 1 diabetes mellitus is a chronic autoimmune disease associated with degeneration of pancreatic β-cells that results in an inability to produce insulin and the need for exogenous insulin administration. It is a significant global health problem as the incidence of this disorder is increasing worldwide. The causes are still poorly understood, although it certainly has genetic and environmental origins. Read More

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http://dx.doi.org/10.3390/molecules24010053DOI Listing
December 2018
2 Reads

Glycemic Control, Cardiac Autoimmunity, and Long-Term Risk of Cardiovascular Disease in Type 1 Diabetes Mellitus: A DCCT/EDIC Cohort-Based Study.

Circulation 2018 Nov 26. Epub 2018 Nov 26.

Medicine-Brigham and Women's Hospital, Joslin Diabetes Center, Harvard Medical School, UNITED STATES.

Background: Poor glycemic control is associated with increased risk of cardiovascular disease (CVD) in type 1 diabetes mellitus (T1DM); however, little is known about mechanisms specific to T1DM. In T1DM, myocardial injury can induce persistent cardiac autoimmunity. Chronic hyperglycemia causes myocardial injury, raising the possibility that hyperglycemia-induced cardiac autoimmunity could contribute to long-term CVD complications in T1DM. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036068DOI Listing
November 2018

Objective Measurement of Physical Activity in Adults With Newly Diagnosed Type 1 Diabetes and Healthy Individuals.

Front Public Health 2018 7;6:360. Epub 2018 Dec 7.

Department of Diabetes, Taunton and Somerset NHS Foundation Trust, Taunton, United Kingdom.

Physical activity (PA) has many benefits in type 1 diabetes mellitus (type 1 DM). However, PA levels in people with type 1 DM have not previously been measured accurately. We aimed to compare objectively measured PA in adults recently diagnosed with type 1 DM and healthy adults. Read More

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https://www.frontiersin.org/article/10.3389/fpubh.2018.00360
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http://dx.doi.org/10.3389/fpubh.2018.00360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293090PMC
December 2018
3 Reads

Validation of a diabetes knowledge test for Indian children, adolescents and young adults with type 1 diabetes mellitus.

Prim Care Diabetes 2018 Dec 20. Epub 2018 Dec 20.

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India. Electronic address:

Introduction: Diabetes knowledge has a large impact on glycemic control. There is a pressing need for creation of validated tests of knowledge for different ethnic groups.

Objective: To create and validate a diabetes knowledge test (DKT) for young Indians with type 1 diabetes mellitus (T1DM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17519918183042
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http://dx.doi.org/10.1016/j.pcd.2018.12.001DOI Listing
December 2018
2 Reads

Trends in Incidence of ESKD in People With Type 1 and Type 2 Diabetes in Australia, 2002-2013.

Am J Kidney Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Diabetes and Epidemiology, Baker Heart and Diabetes Institute, Melbourne, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia.

Rationale & Objective: The number of people with diabetes and end-stage kidney disease (ESKD) is increasing worldwide, but it is unknown whether this indicates an increasing risk for ESKD in people with diabetes. We examined temporal trends in the incidence of ESKD within the Australian population with diabetes from 2002 to 2013.

Study Design: Follow-up study using a national health care services registry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386183108
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http://dx.doi.org/10.1053/j.ajkd.2018.10.005DOI Listing
December 2018
3 Reads

Worse Metabolic Control and Dynamics of Weight Status in Adolescent Girls Point to Eating Disorders in the First Years after Manifestation of Type 1 Diabetes Mellitus: Findings from the Diabetes Patienten Verlaufsdokumentation Registry.

J Pediatr 2018 Dec 20. Epub 2018 Dec 20.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology (ZIBMT), University of Ulm, Ulm, Germany; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.

Objective: To assess indications of eating disorders in girls with type 1 diabetes mellitus (T1DM).

Study Design: In total 31 556 girls aged >6 months and <23 years of age with T1DM from the Diabetes Patienten Verlaufsdokumentation (DPV) cohort were analyzed including 155 (0.49%) girls with anorexia nervosa, 85 (0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183168
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http://dx.doi.org/10.1016/j.jpeds.2018.11.037DOI Listing
December 2018
5 Reads

Characterization of diabetes following pancreatic surgery in patients with congenital hyperinsulinism.

Orphanet J Rare Dis 2018 Dec 22;13(1):230. Epub 2018 Dec 22.

Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.

Background: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infancy that leads to unfavourable neurological outcome if not treated adequately. In patients with severe diffuse CHI it remains under discussion whether pancreatic surgery should be performed or intensive medical treatment with the acceptance of recurrent episodes of mild hypoglycaemia is justified. Near-total pancreatectomy is associated with high rates of insulin-dependent diabetes mellitus and exocrine pancreatic insufficiency. Read More

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http://dx.doi.org/10.1186/s13023-018-0970-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304089PMC
December 2018
1 Read

Gastrointestinal Bleeding Secondary to Iliac Artery Pseudoaneurysm in a Patient With Remote Pancreas Transplant: A Case Report.

Transplant Proc 2018 Dec 29;50(10):4087-4089. Epub 2018 May 29.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. Electronic address:

Background: Vascular complications represent the most common cause of early graft failure after pancreatic transplantation (PT). Pseudoaneurysms are uncommon vascular complications that usually present within the first year post transplantation.

Case Report: A 49-year-old man with history of type 1 diabetes mellitus presented for evaluation with a 2-day history of painless hematochezia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183072
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http://dx.doi.org/10.1016/j.transproceed.2018.05.015DOI Listing
December 2018
8 Reads

Preneoplastic Lesion in a Pancreas Allograft: Dilemma for the Pancreas Transplant Surgeon.

Transplant Proc 2018 Dec 30;50(10):3694-3697. Epub 2018 Jun 30.

Division of Transplantation, Department of Surgery, University of Minnesota Medical School, Minneapolis, MN.

Although the relationship between immunosuppression and cancer risk is well-documented, the association between immunosuppression and the development of preneoplastic lesions (PNL) is less clear. PNLs pose a unique clinical conundrum in the transplanted pancreas because their prevalence in the general population is not infrequent. We present the case of a 58-year-old man with a history of diabetes mellitus type 1 who underwent successful pancreas transplantation with bladder drainage. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.06.047DOI Listing
December 2018

DETERMINING THE EFFECT OF DIABETES DURATION ON RETINAL AND CHOROIDAL THICKNESSES IN CHILDREN WITH TYPE 1 DIABETES MELLITUS.

Retina 2018 Dec 18. Epub 2018 Dec 18.

Department of Ophthalmology. Chair of Ophthalmology and Optometry. Heliodor Swiecicki University Hospital. Poznan University of Medical Sciences, Poland.

Purpose: Determining the effect of diabetes mellitus duration on retinal and choroidal thicknesses in children with Type 1 diabetes mellitus (T1DM).

Methods: Children (aged 6-18 years) with Type 1 diabetes and no diabetic retinopathy and age-matched controls were examined using Topcon spectral domain optical coherence tomography. Choroidal thickness and retinal thickness in macula area were measured. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002420DOI Listing
December 2018

Earlier puberty in boys with type 1 diabetes mellitus compared to a simultaneously recruited group of control adolescents.

Pediatr Diabetes 2018 Dec 21. Epub 2018 Dec 21.

Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile.

Background: Recent studies have suggested that there is an earlier age of onset of puberty in healthy boys. However, no study has determined the age of pubertal development in boys with type 1 diabetes (T1D) and compared the results with a simultaneously recruited group of healthy children.

Objective: The aim of this study was to evaluate the age of pubertal events in boys with TD1 and determine whether the duration of diabetes, metabolic control or insulin dose are associated with the age of puberty in boys with T1D. Read More

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http://dx.doi.org/10.1111/pedi.12811DOI Listing
December 2018

[Protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1020-1023

Department of Endocrinology and Inherited Metabolism, Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450000, China.

Objective: To study the protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus (T1DM) and its mechanism.

Methods: A total of 46 children with T1DM (with a course of disease of 0.5-1 year) were randomly divided into an intervention group and a non-intervention group (n=23 each). Read More

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December 2018

Clinical profile of children with diabetic ketoacidosis in fifteen years of management in a Critical Care Unit.

Rev Chil Pediatr 2018 Aug;89(4):491-498

División de Pediatría, Hospital Clínico, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction: Diabetic ketoacidosis (DKA) is the main cause of morbidity and mortality in children with type 1 diabetes mellitus (T1DM) due to clinical and biochemical alterations associated, cerebral edema as one of the most critical because of the high mortality rates and long-term neurological se quelae.

Objective: To analyze the clinical characteristics and complications of patients with DKA ad mitted to a pediatric intensive care unit.

Patients And Methods: Retrospective study of DKA patients treated at the Hospital Clínico, Pontificia Universidad Católica de Chile (UPCPUC) between 2000 and 2015. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000703DOI Listing

Health-related quality of life in a cohort of youths with type 1 diabetes.

Rev Assoc Med Bras (1992) 2018 Nov;64(11):1038-1044

Universidade Federal do Paraná, Pediatric Endocrinology Unit, Department of Pediatrics, Hospital de Clínicas, Curitiba, PR, Brasil.

Objective: Health-related quality of life (HRQOL) in type 1 diabetes mellitus (T1DM) has been widely studied. The objectives of this study were to evaluate and identify the factors influencing the HRQOL of children and adolescents with T1DM.

Material And Methods: In total, 59 patients (9-16 years, T1DM for ≥1 year) responded to a version of the Diabetes Quality of Life Instrument for Youth (DQOLY) adapted to adapted to Brazilian patients, the Instrumento de Qualidade de Vida para Jovens com Diabetes (IQVJD). Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.64.11.1038DOI Listing
November 2018
6 Reads

Diabetic Neuropathy Prevalence and Its Associated Risk Factors in Two Representative Groups of Type 1 and Type 2 Diabetes Mellitus Patients from Bihor County.

Maedica (Buchar) 2018 Sep;13(3):229-234

Clinical Emergency Hospital of Oradea, Internal Medicine-Diabetes Department, Oradea, Bihor County, Romania.

Background: Diabetic neuropathy has an important impact on the quality of life of affected individuals due to the presence of chronic symptoms like distal neuropathic pain, but it also influences the survival of diabetic patients, given that the clinical forms of diabetic neuropathy produce complications such as diabetic foot syndrome in distal peripheral neuropathy or life threatening arrhythmias in autonomic cardiac neuropathy. The prevalence of diabetic neuropathy in representative cohorts is very discordant in numerous studies, and our purpose was to evaluate the frequency of this microvascular complication in Bihor County and to determine some risk factors for its development in order to perform a more rigorous screening in certain risk groups.

Material And Methods: We formed two representative cohorts for type 1 and type 2 diabetes mellitus population in our county and applied a questionnaire with three subsets of questions for sensitive, motor and autonomic symptoms. Read More

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http://dx.doi.org/10.26574/maedica.2018.13.3.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290177PMC
September 2018
10 Reads

Target engagement and cellular fate of otelixizumab; a repeat dose escalation study of an anti-CD3ε mAb in New-Onset Type 1 Diabetes Mellitus Patients.

Br J Clin Pharmacol 2018 Dec 19. Epub 2018 Dec 19.

Research and Development, GlaxoSmithKline, London, UK.

Aims: This paper describes the pharmacological findings from a study where otelixizumab, an anti-CD3 mAb, was dosed in new onset Type 1 Diabetes Mellitus (NOT1DM) patients. This is the first time that the full dose-response of an anti-CD3 mAb has been investigated in the clinic. The data have been validated using a previously developed Pharmacokinetic/Pharmacodynamic (PK/PD) model of otelixizumab to simulate the interplay between drug administration, CD3 target engagement and down-modulation. Read More

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http://dx.doi.org/10.1111/bcp.13842DOI Listing
December 2018

Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase 2 trial (ATTRACTION-4).

Ann Oncol 2018 Dec 19. Epub 2018 Dec 19.

Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Nivolumab is approved as an option for third- or later-line treatment for advanced gastric/gastroesophageal junction (G/GEJ) cancer in several countries after ATTRACTION-2. To further improve the therapeutic efficacy of first-line therapy, exploration of a nivolumab-chemotherapy combination is warranted. In part 1 (phase 2) of ATTRACTION-4, the safety and efficacy of nivolumab combined with S-1 plus oxaliplatin (SOX) or capecitabine plus oxaliplatin (CapeOX) as first-line therapy for unresectable advanced or recurrent human epidermal growth factor receptor 2 (HER2)-negative G/GEJ cancer were evaluated. Read More

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http://dx.doi.org/10.1093/annonc/mdy540DOI Listing
December 2018

Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.

Circulation 2018 Dec;138(25):2895-2907

Division of Pediatric Endocrinology (P.B., M.C.-G., L.P., A.B., Y.G.R., K.J.N.), University of Colorado School of Medicine, Aurora.

Background: Cardiovascular disease is the leading cause of mortality in type 1 diabetes mellitus (T1DM) and relates strongly to insulin resistance (IR). Lean and obese adolescents with T1DM have marked IR. Metformin improves surrogate markers of IR in T1DM, but its effect on directly measured IR and vascular health in youth with T1DM is unclear. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035525DOI Listing
December 2018
14.430 Impact Factor

"I kind of gave up on it after a while, became too hard, closed my eyes, didn't want to know about it"-adults with type 1 diabetes mellitus describe defeat in the context of low social support.

Health Expect 2018 Nov 22. Epub 2018 Nov 22.

College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Background: Type 1 diabetes mellitus (T1DM) is a lifelong condition that requires diligent self-management to avoid complications. Living with T1DM is a considerable challenge and the inability to follow a prescribed regimen is often termed non-compliance. However, this fails to acknowledge that for some people the barriers to glycaemic control may be insurmountable. Read More

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http://dx.doi.org/10.1111/hex.12850DOI Listing
November 2018

Latent Autoimmune Diabetes in Adults: A Review on Clinical Implications and Management.

Diabetes Metab J 2018 Dec;42(6):451-464

Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy.

Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by a less intensive autoimmune process and a broad clinical phenotype compared to classical type 1 diabetes mellitus (T1DM), sharing features with both type 2 diabetes mellitus (T2DM) and T1DM. Since patients affected by LADA are initially insulin independent and recognizable only by testing for islet-cell autoantibodies, it could be difficult to identify LADA in clinical setting and a high misdiagnosis rate still remains among patients with T2DM. Ideally, islet-cell autoantibodies screening should be performed in subjects with newly diagnosed T2DM, ensuring a closer monitoring of those resulted positive and avoiding treatment of hyperglycaemia which might increase the rate of β-cells loss. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4093/dmj.2018.01
Publisher Site
http://dx.doi.org/10.4093/dmj.2018.0190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300440PMC
December 2018
9 Reads