650,284 results match your criteria Diabetes Management [Journal]


Quality of Bowel Preparation for Colonoscopy in Patients with a History of Abdomino-Pelvic Surgery: Retrospective Cohort Study.

Yonsei Med J 2019 Jan;60(1):73-78

Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

Purpose: Prior abdomino-pelvic (AP) surgery makes colonoscopy difficult and can affect bowel preparation quality. However, bowel preparation quality has been found to vary according to prior AP surgery type. We examined the relationship of prior AP surgery type with bowel preparation quality in a large-scale retrospective cohort. Read More

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January 2019

CCN1 regulates cholesterol metabolism - OxLDL enters the matrix.

Acta Physiol (Oxf) 2018 Dec 16:e13239. Epub 2018 Dec 16.

Heart Center Bonn, Medical Department II, University Hospital Bonn, Sigmund-Freud-Str. 2553127, Bonn, Germany.

In the present issue of Acta physiologica, Zhao et al. publish an article, in which they investigate how the extracellular matrix protein CCN1 regulates cholesterol efflux from macrophages in atherosclerotic plaques and biliary excretion of cholesterol in the liver.1 The development of atherosclerotic plaques is a primarily inflammatory process, which is triggered by well-established risk factors including arterial hypertension, diabetes, hypercholesterolemia and smoking. Read More

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December 2018
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Mortality Trends of Liver Diseases from 1981 to 2016 and the Projection to 2035 in Taiwan: An Age-Period-Cohort Analysis.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Background: Projections on liver diseases mortality can provide a basis for evaluating the World Health Organization's "25 by 25" goal and can help health care systems design appropriate control strategies. This study evaluated whether the 25 by 25 goal can be achieved in Taiwan and discussed possible future control strategies.

Methods: Age-period-cohort models are used to estimate the mortality trends of liver diseases from 1981 to 2016 and project these trends to 2035. Read More

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December 2018

Serum adipocyte fatty acid-binding protein levels: an indicator of non-alcoholic fatty liver disease in Chinese individuals.

Liver Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, 200233, China.

Background & Aims: Serum adipocyte fatty acid-binding protein (A-FABP) is closely correlated to metabolic disorders such as obesity and insulin resistance (IR). Non-alcoholic fatty liver disease (NAFLD) is a typical feature of IR in the liver. The aim of this study was to explore the relationship between serum A-FABP levels and NAFLD. Read More

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December 2018

Parental awareness of newborn bloodspot screening in Ireland.

Ir J Med Sci 2018 Dec 15. Epub 2018 Dec 15.

Graduate Entry Medical School and Centre for Interventions in Infection, Inflammation & Immunity (4i), University of Limerick, Limerick, Ireland.

Background: There is little known regarding how familiar parents are with the newborn bloodspot screening (NBS) test or how well parents of a child with a screen-detected condition understand that condition initially.

Aim: The study aim was to examine parental NBS awareness and conditions screened.

Methods: Two studies were conducted: [1] Parents of children with cystic fibrosis (CF) detected via NBS and subsequently, diagnosed (n = 124) completed a telephone questionnaire regarding information they received at the time of NBS. Read More

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December 2018

College Students' Perception of Current and Projected 30-Year Cardiovascular Disease Risk Using Cluster Analysis with Internal Validation.

Authors:
Dieu-My T Tran

J Community Health 2018 Dec 15. Epub 2018 Dec 15.

School of Nursing, University of Nevada, Las Vegas, 4505 S. Maryland Pkwy, Box 453018, Las Vegas, NV, 89154-3018, USA.

Cardiovascular risk factors in young adults at a national level are less than ideal specifically for hypercholesterolemia, hypertension, and diabetes. Explore college students' perception of their 30-year cardiovascular disease (CVD) risk using cluster analysis technique with internal validation. This is a descriptive and cross-sectional study. Read More

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December 2018
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Association between glycemic control, age, and outcomes among intensively treated patients with acute myeloid leukemia.

Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.

Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Purpose: To investigate the impact of hyperglycemia and glycemic variability during intensive acute myeloid leukemia therapy (AML) on outcomes by age.

Methods: Retrospective study of 262 consecutive patients with newly diagnosed AML hospitalized for intensive induction. Hyperglycemia was assessed by mean blood glucose (BG) (mg/dL) during hospitalization and glycemic variability was determined by the standard deviation (SD) of mean BG. Read More

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December 2018

Triple therapy at discharge from internal medicine wards in heart failure patients with reduced ejection fraction: results from an observational study.

Clin Ter 2018 Nov-Dec;169(6):e287-e291

Internal Medicine, San Giuseppe Hospital, Empoli (Firenze), Italy.

Background: Guidelines recommend triple therapy (TT) with ACE inhibitors or ARBs, beta-blockers and mineralcorticoid receptor antagonists in symptomatic heart failure patients with ejection fraction <35 % (HFrEF). Nevertheless, many patients remain untreated. This study was aimed to evaluate the use of TT in HFrEF patients discharged from internal medicine wards of Tuscany, Italy. Read More

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December 2018

A Mediterranean Diet with an Enhanced Consumption of Extra Virgin Olive Oil and Pistachios Improves Pregnancy Outcomes in Women Without Gestational Diabetes Mellitus: A Sub-Analysis of the St. Carlos Gestational Diabetes Mellitus Prevention Study.

Ann Nutr Metab 2018 Dec 14;74(1):69-79. Epub 2018 Dec 14.

Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid,

Aims: The aim of the study was to evaluate the effect of a Mediterranean diet (MedDiet), enhanced with extra virgin olive oil (EVOO) and nuts, on a composite of adverse maternofoetal outcomes of women with normoglycemia during pregnancy.

Methods: This was a sub-analysis of the St Carlos gestational diabetes mellitus Prevention Study. Only normoglycemic women were analysed (697). Read More

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December 2018
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Diagnostic Accuracy of Digital Retinal Fundus Image Analysis in Detecting Diabetic Maculopathy in Type 2 Diabetes Mellitus.

Ophthalmic Res 2018 Dec 14:1-7. Epub 2018 Dec 14.

School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland, Belfast, United Kingdom.

Background: Digital retinal imaging is the gold standard technique for diabetic retinopathy (DR) and diabetic macular oedema (DME) assessment during DR screening.

Objectives: To evaluate the diagnostic accuracy of digital retinal fundus image (DRFI) analysis in detecting DME using three manual grading systems (MGS) and comparing it with optical coherence tomography (OCT) findings.

Method: A total of 287 DRFI of 287 eyes were analysed. Read More

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December 2018

Daily Supplementation with 4000 IU Vitamin D3 for Three Years Does Not Modify Cardiovascular Risk Markers in Patients with Advanced Heart Failure: The Effect of Vitamin D on Mortality in Heart Failure Trial.

Ann Nutr Metab 2018 Dec 14;74(1):62-68. Epub 2018 Dec 14.

Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr University Bochum, Bad Oeynhausen, Germany.

Background/aims: We aimed to investigate the effect of a moderately high vitamin D dose on lipid parameters and biochemical markers of vascular calcification (VC) in patients with established cardiovascular disease.

Methods: We included in this pre-specified secondary analysis of a randomized controlled trial 161 patients with advanced heart failure and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L (vitamin D group: n = 80; placebo group: n = 81), who received a daily vitamin D3 supplement of 4,000 IU for 3 years. We assessed between-group differences of the lipid parameters total-cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and triglycerides, and the VC markers fetuin-A and non-phosphorylated undercarboxylated matrix gla protein (MGP) at study termination, with adjustment for baseline values. Read More

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December 2018

Metformin Affects Heme Function as a Possible Mechanism of Action.

G3 (Bethesda) 2018 Dec 15. Epub 2018 Dec 15.

Stanford University

Metformin elicits pleiotropic effects that are beneficial for treating diabetes, and as well as particular cancers and aging. In spite of its importance, a convincing and unifying mechanism to explain how metformin operates is lacking. Here we describe investigations into the mechanism of metformin action through heme and hemoprotein(s). Read More

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December 2018

Physical activity less than the recommended amount may prevent the onset of major biological risk factors for cardiovascular disease: a cohort study of 198 919 adults.

Br J Sports Med 2018 Dec 15. Epub 2018 Dec 15.

IMDEA Food Institute, CEI UAM+CSIC, Madrid, Spain.

Objectives: We examined the dose-response relationship between physical activity (PA) and incidence of cardiovascular disease (CVD) risk factors in adults in Taiwan.

Methods: This study included 1 98 919 participants, aged 18-97 years, free of CVD, cancer and diabetes at baseline (1997-2013), who were followed until 2016. At baseline, participants were classified into five PA levels: inactive' (0 metabolic equivalent of task (MET)-h/week), 'lower insufficiently active' (0. Read More

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December 2018

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice.

Neurobiol Aging 2018 Nov 17;75:98-108. Epub 2018 Nov 17.

Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

Type 2 diabetes mellitus (T2DM) increases the risk for Alzheimer's disease (AD). Human AD brains show reduced glucose metabolism as measured by [18F]fluoro-2-deoxy-2-D-glucose positron emission tomography (FDG-PET). Here, we used 14-month-old wild-type (WT) and APP/PS1 (APP/PS1) transgenic mice to investigate how a single dose of intranasal insulin modulates brain glucose metabolism using FDG-PET and affects spatial learning and memory. Read More

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November 2018

Tough decisions in medical specialty camps: Relationships between camp dosage, outcomes, and camper attendance.

Soc Sci Med 2018 Dec 10;221:49-57. Epub 2018 Dec 10.

Department of Parks, Recreation and Tourism, Clemson University, Clemson, USA.

Rationale: Medical specialty camps play a significant role in the lives of the youth they serve. These camps have been found to improve self-determination in campers, to develop camper skills in managing a disability or coping with a diagnosis, and to provide campers with respite/escape from the challenges associated with their disability or diagnosis. Youth attending medical specialty camps are often funded through full or partial scholarships, mitigating a significant constraint to their participation. Read More

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December 2018

Exenatide modulates expression of metalloproteinases and their tissue inhibitors in TNF-α stimulated human retinal pigment epithelial cells.

Pharmacol Rep 2018 Oct 3;71(1):175-182. Epub 2018 Oct 3.

Department of Ophthalmology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Background: Diabetic retinopathy (DR) is one of the most common complications of diabetes and the leading cause of acquired blindness in adults. In diabetic patients hyperglycemia induces complex metabolic abnormalities affecting retinal homeostasis, and promotes retinal inflammation and angiogenesis. Incretin mimetic drugs such exenatide, are a relatively new group of drugs used in the treatment of diabetes. Read More

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October 2018

Proteomics turns functional.

J Proteomics 2018 Dec 13. Epub 2018 Dec 13.

Department of Science and High Technology, Center of Bioinformatics, University of Insubria, Busto Arsizio, Italy. Electronic address:

Proteomics is acquiring a pivotal role in the comprehensive understanding of human biology. Biochemical processes involved in complex diseases, such as neurodegenerative diseases, diabetes and cancer, can be identified by combining proteomics analysis and bioinformatics tools. In the last ten years, the main output of differential proteomics investigations evolved from long lists of proteins to the generation of new hypotheses and their functional verification. Read More

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December 2018

Early metabolic changes in the gut leads to higher expression of intestinal alpha glucosidase and thereby causes enhanced postprandial spikes.

Life Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Biochemistry, Shivaji University, Kolhapur, 416 004 (M.S.), India. Electronic address:

Aims: Prediabetes manifests several years earlier, before it progresses to diabetes. It is essential to track the earliest metabolic changes occurring in the prediabetic state and to understand the precise mechanism of how diabetes is initiated.

Main Methods: Alpha glucosidase was isolated from rat intestine and assayed using maltose as substrate. Read More

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December 2018

Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: an update.

Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.

Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands.

Uridine adenosine tetraphosphate (UpA), biosynthesized by activation of vascular endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium-derived vasoconstrictor in perfused rat kidney. Subsequently, the effect of UpA on vascular tone regulation was intensively investigated in arteries isolated from different vascular beds in rodents including rat pulmonary arteries, aortas, mesenteric and renal arteries as well as mouse aortas, in which UpA produces vascular contraction. In contrast, UpA produces vascular relaxation in porcine coronary small arteries and rat aortas. Read More

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December 2018
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National Study of Ocular Hospitalizations in Medicare Beneficiaries.

Am J Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois USA; Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois USA; Veterans Affairs Health Services Research and Development Service, Chicago, Illinois USA. Electronic address:

Purpose: To study the characteristics of Medicare Beneficiaries hospitalized for ophthalmic conditions DESIGN: Cross-sectional study METHODS: The 2015 National Medicare 100% Inpatient Limited Dataset was analyzed to identify all patients with either an admitting or primary diagnoses for an ophthalmic condition using ICD-9-CM codes. All other hospitalized Medicare patients served for comparison. Comorbidities were calculated using the Elixhauser Comorbidity Index. Read More

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December 2018
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Risk factors for admission after shoulder arthroscopy.

J Shoulder Elbow Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Orthopaedic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: Shoulder arthroscopy is a common orthopedic procedure typically performed on an outpatient basis. Occasionally, patients require an unplanned hospital admission. An understanding of the incidence and risk factors for admission after shoulder arthroscopy may assist surgeons in determining which patients may be susceptible to unplanned admission after surgery. Read More

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December 2018

Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing.

Mol Metab 2018 Nov 27. Epub 2018 Nov 27.

Centre des Sciences du Goût et de l'Alimentation, UMR CNRS 6265, INRA 1324, AgroSup, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France. Electronic address:

Objective: Hypothalamic glucose sensing (HGS) initiates insulin secretion (IS) via a vagal control, participating in energy homeostasis. This requires mitochondrial reactive oxygen species (mROS) signaling, dependent on mitochondrial fission, as shown by invalidation of the hypothalamic DRP1 protein. Here, our objectives were to determine whether a model with a HGS defect induced by a short, high fat-high sucrose (HFHS) diet in rats affected the fission machinery and mROS signaling within the mediobasal hypothalamus (MBH). Read More

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November 2018

Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal.

J Clin Lipidol 2018 Nov 20. Epub 2018 Nov 20.

Program in Personalized and Genomic Medicine, and Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.

Background: Postprandial lipemia (PPL), defined as a prolonged or elevated rise in triglycerides that accompanies fat feeding, is a significant risk factor for coronary heart disease and associated comorbidities. The impact of PPL on coronary heart disease risk is underscored by the preponderance of each day spent in the postprandial state.

Objective: In this study, we evaluated cross-sectionally the association between usual (ie, noninterventional) physical activity and the 6-hour triglyceride response to a standardized high-fat meal. Read More

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November 2018

Bi-directional drug-microbiome interactions of anti-diabetics.

EBioMedicine 2018 Dec 12. Epub 2018 Dec 12.

Department of Internal Medicine- Molecular Medicine, Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address:

Type 2 diabetes (T2D) has become a global epidemic. Although several drugs are available to manage T2D, problems associated with person-to-person variability in drug efficacy and potential side-effects remain unresolved. Owing to the emerging role of the gut microbiome in obesity and T2D, the interaction between gut microbes and anti-diabetic drugs and its influence on drugs' functions remains of immediate research interest. Read More

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December 2018

Addition of proximal intervention to carotid endarterectomy increases risk of stroke and death.

J Vasc Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Mass. Electronic address:

Objective: Adding ipsilateral, proximal endovascular (IPE) intervention to carotid endarterectomy (CEA) for the treatment of tandem bifurcation and supra-aortic trunk disease is controversial. Some suggest that this combined strategy (CEA + IPE) confers no risk over isolated CEA (ICEA). Others disagree, reserving CEA + IPE for symptomatic patients. Read More

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December 2018

Diabetes mellitus and risk of pancreatic cancer in China: A meta-analysis based on 26 case-control studies.

Prim Care Diabetes 2018 Dec 12. Epub 2018 Dec 12.

Department of General Surgery, Sixth Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030008, China.

Aims: The relationship between diabetes mellitus and pancreatic cancer risk from is uncertain based on the results of existing publications. The current report updated and re-evaluated the possible association between diabetes mellitus and pancreatic cancer risk in China.

Methods: Six databases (PubMed, Embase, Web of Science, the Cochrane Library, the Chinese Biomedical Database, and the Chinese National Knowledge Infrastructure) were used for the literature search up to October 2017. Read More

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December 2018

Prevention and screening recommendations in type 2 diabetes: Review and critical appraisal of clinical practice guidelines.

Prim Care Diabetes 2018 Dec 12. Epub 2018 Dec 12.

College of Pharmacy, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address:

The aim of this review was to identify and appraise guidelines reporting recommendations for the screening and prevention of type 2 diabetes. Five guidelines were included for analysis and all were endorsed by national or international organizations. All guidelines were recommended for practice with or without modifications for both prevention and screening. Read More

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December 2018

Disparities in Preventable Hospitalizations Among Public Housing Developments.

Am J Prev Med 2018 Dec 12. Epub 2018 Dec 12.

Office of Policy, Planning and Strategic Data Use, New York City Department of Health and Mental Hygiene, New York, New York. Electronic address:

Introduction: This study assesses preventable hospitalization rates among New York City residents living in public housing developments compared with all New York City residents and residents in low-income areas. Additionally, preventable hospitalization rates by development (one or multiple buildings in close proximity and served by the same management office) were determined.

Methods: The 2010-2014 New York City hospital discharge data were geocoded and linked with New York City Housing Authority records using building-level identifiers. Read More

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December 2018

Histopathologic Characterization of Peripheral Arteries in Subjects With Abundant Risk Factors: Correlating Imaging With Pathology.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

CVPath Institute, Gaithersburg, Maryland.

Objectives: The aim of this study was to comprehensively evaluate the pathology of the lower extremity arteries across their entire length in subjects dying with abundant risk factors and to evaluate the clinical and imaging implications of the pathological characteristics.

Background: Lower extremity peripheral arterial disease is a major cause of cardiovascular morbidity, but a systematic characterization of the pathology has never been undertaken.

Methods: Twelve legs were obtained from 8 cadavers with histories of coronary risk factors (median age 82 years, 6 men); 8 of 12 legs were evaluated using computed tomography before the major peripheral arteries were dissected along their entire length. Read More

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December 2018

Dyslipidaemia in Africa-comment on a recent systematic review - Authors' reply.

Lancet Glob Health 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa; Non-communicable Disease Research Unit, South African Medical Research Council, Cape Town, South Africa. Electronic address:

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December 2018
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Off-clamp vs on-clamp robotic partial nephrectomy: Perioperative, functional and oncological outcomes from a propensity-score matching between two high-volume centers.

Eur J Surg Oncol 2018 Dec 9. Epub 2018 Dec 9.

Glickman Urological and Kidney Institute, Department of Urology, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Introduction: Aim of the study was to compare perioperative, functional and oncological outcomes after off-clamp vs on-clamp robotic partial nephrectomy (RPN).

Materials And Methods: Patients who underwent off-clamp or on-clamp (warm ischemia) RPN were extracted from 2 institutional prospectively-maintained databases. 123 patients who underwent off-clamp RPN at one institution were excluded, so that each institution contributed with unselected patients (institution 1:on-clamp RPN vs institution 2:off-clamp). Read More

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December 2018

A Pilot Study of Soluble Form of LOX-1 as a Novel Biomarker for Neonatal Hypoxic-Ischemic Encephalopathy.

J Pediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. Electronic address:

Objective: To evaluate the soluble form of lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) as a biomarker of severity staging and prognosis in neonatal hypoxic-ischemic encephalopathy (HIE).

Study Design: We performed an observational study enrolling 27 infants with HIE and 45 control infants of gestational age ≥36 weeks and birth weight ≥1800 g. The HIE criteria were pH ≤7. Read More

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December 2018

Body Mass Index, Change in Weight, Body Weight Variability and Outcomes in Type 2 Diabetes Mellitus (from the ACCORD Trial).

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Heart and Vascular Center of Excellence, Wake Forest Baptist Health, Winston Salem, North Carolina. Electronic address:

Weight management is highly recommended to patients with diabetes mellitus. However, this prescription is often characterized by weight fluctuations. It remains unclear the effects of weight fluctuations on outcomes in diabetes mellitus. Read More

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December 2018

Comparison of the Diagnostic Performance of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve in Patients With Versus Without Diabetes Mellitus (from the MACHINE Consortium).

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Department of Radiology & Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Stanford University School of Medicine, Cardiovascular Institute, Stanford, California.

Coronary computed tomography angiography-derived fractional flow reserve (CT-FFR) is a noninvasive application to evaluate the hemodynamic impact of coronary artery disease by simulating invasively measured FFR based on CT data. CT-FFR is based on the assumption of a normal coronary microvascular response. We assessed the diagnostic performance of a machine-learning based application for on-site computation of CT-FFR in patients with and without diabetes mellitus with suspected coronary artery disease. Read More

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November 2018

Glycated Hemoglobin and Outcomes of Heart Failure (from Get With the Guidelines-Heart Failure).

Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.

Division of Cardiology, Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, California. Electronic address:

Glycated hemoglobin (HbA) is a risk factor for new onset heart failure (HF). There is however a paucity of data evaluating its association with outcomes in patients with established HF. We assessed the relation of HbA with outcomes among hospitalized HF patients. Read More

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December 2018

Lixisenatide enhances mitochondrial biogenesis and function through regulating the CREB/PGC-1α pathway.

Authors:
Zhen Zhao Yanhua Pu

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiology, The No.4 Hospital of Jinan, 250031, Shandong, China. Electronic address:

Mitochondrial dysregulation has been associated with vascular endothelial dysfunction and pathophysiological development of cardiovascular diseases. Lixisenatide is a drug approved by the US Food and Drug Administration for the treatment of type 2 diabetes (T2D). Little information regarding the effects of lixisenatide on mitochondrial function in endothelial cells has been reported before. Read More

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December 2018

Absence of spontaneous regeneration of endogenous pancreatic β-cells after chemical-induced diabetes and no effect of GABA on α-to-β cell transdifferentiation in rhesus monkeys.

Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.

Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, 110-79, South Korea; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, 110-79, South Korea; Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, 110-79, South Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, 110-79, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 110-79, South Korea; Biomedical Research Institute, Seoul National University Hospital, Seoul, 110-799, South Korea. Electronic address:

β-cell deficiency is common feature of type 1 and late-stage of type 2 diabetes mellitus. Thus, β-cell replacement therapy has been the focus of regenerative medicine past several decades. Particularly, evidences suggest that β-cell regeneration via transdifferentiation from sources including α-cells is promising. Read More

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December 2018

Megakaryocytic leukemia 1 (MKL1) mediates high glucose induced epithelial-mesenchymal transition by activating LOX transcription.

Biochem Biophys Res Commun 2018 Dec 13. Epub 2018 Dec 13.

Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, Nanjing, China; Institute of Biomedical Research, Liaocheng University, Liaocheng, China. Electronic address:

Diabetic retinopathy (DR) is one of the most devastating complications of diabetes mellitus. When exposed to high glucose (HG), retinal epithelial cells undergo profound alterations both morphologically and functionally in a well-conserved process known as epithelial-to-mesenchymal transition (EMT). The mechanism governing HG-induced EMT in retinal epithelial cells is not completely understood. Read More

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December 2018

Diuretic treatment of the patient with diabetes and heart failure. Role of SGLT2 inhibitors and similarities with carbonic anhydrase inhibitors.

Rev Clin Esp 2018 Dec 12. Epub 2018 Dec 12.

Medicina Interna, Instituto de Investigación Biomédica de Salamanca (IBSAL), Hospital Universitario de Salamanca, Salamanca, España.

Sodium-glucose cotransporter-2 inhibitors have changed the concept of the effects that hypoglycemic drugs have on hearth failure (HF). For the first time, a therapeutic group has modified the evolution of HF. Its effect goes beyond glycemic control, and different theories have been postulated to justify this benefit. Read More

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December 2018

The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target.

Prostaglandins Leukot Essent Fatty Acids 2019 Jan 29;140:51-56. Epub 2018 Nov 29.

Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands. Electronic address:

The endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeutics. The emerging picture not only reinforces endocannabinoids as potent regulators of cellular metabolism but also reveals that endocannabinoid signaling is mechanistically more complex and diverse than originally thought. Read More

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January 2019

Urinary 8-iso-prostaglandin F as a risk marker for the vulnerability of culprit plaque in diabetic patients with stable coronary artery disease.

Prostaglandins Leukot Essent Fatty Acids 2019 Jan 22;140:11-17. Epub 2018 Nov 22.

Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.

We evaluated the association of urinary excretion of 8-iso-prostaglandin F (8-iso-PGF) with the vulnerability of culprit lesions in 156 age- and sex-matched diabetic stable coronary artery disease (CAD) patients with or without thin-capped fibroatheroma (TCFA) identified by iMAP intravascular ultrasound. Fasting urinary 8-iso-PGF level was measured and corrected by creatinine clearance. Compared to non-TCFA group, patients with TCFA had higher urinary 8-iso-PGF levels [114. Read More

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January 2019

Enteromorpha prolifera oligomers relieve pancreatic injury in streptozotocin (STZ)-induced diabetic mice.

Carbohydr Polym 2019 Feb 11;206:403-411. Epub 2018 Nov 11.

State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production & Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China. Electronic address:

The polysaccharides of Enteromorpha prolifera (PEP) displayed various bioactivities such as anti-viral, anti-inflammatory and immune-regulative effects. However, no studies were performed on the biological effect of Enteromorpha prolifera oligomers (EPO). In this study, we prepared EPO and evaluated their anti-diabetic effect. Read More

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February 2019

Primary cultured neuronal networks and type 2 diabetes model mouse fatty liver tissues in aqueous liquid observed by atmospheric SEM (ASEM): Staining preferences of metal solutions.

Micron 2018 Nov 23;118:9-21. Epub 2018 Nov 23.

Biomedical Research Institute, National Institute of Industrial Science and Technology (AIST), Higashi 1-1-1, Tsukuba, Ibaraki, 305-8566, Japan. Electronic address:

Neural networking, including axon targeting and synapse formation, is the basis of various brain functions, including memory and learning. Diabetes-mellitus affects peripheral nerves and is known to cause fatty liver disease. Electron microscopy (EM) provides the resolution required to observe changes in fine subcellular structures caused by such physiological and pathological processes, but samples are observed in vacuum. Read More

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November 2018

Effectiveness of Fosfomycin Tromethamine Prophylaxis in Preventing Infection Following Ultrasound-guided Prostate Needle Biopsies: Results from a Large Canadian Cohort.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology and Infectious Diseases, Université de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4,. Electronic address:

Background: Rates of infection following ultrasound-guided transrectal prostate needle biopsy (TRUSPB) are increasing. We aimed to evaluate the effectiveness of fosfomycin tromethamine (FMT) prophylaxis in preventing post-TRUSPB infectious complications.

Methods: This nested case-control study included patients who underwent TRUSPB in a Canadian tertiary care hospital, and developed post-TRUSPB bacteremia or urinary tract infections. Read More

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December 2018

Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Department of Histology and Embryology, Medical Faculty, Akdeniz University, 07070, Antalya, Turkey. Electronic address:

Objective: The mammalian target of rapamycin (mTOR) signaling pathway has newly been recommended to be a nutrient sensor in the placenta. It is speculated that mTORC1 may be activated in diabetes, associated with increased placental nutrient availability. Thus, we aimed to investigate the mTOR signaling pathway both in diabetic and non-diabetic placenta and searched for the alterations of angiogenic factors VEGF, VEGFR1 and VEGFR2. Read More

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December 2018

Reduction of cerebral blood flow in community-based adults with subclinical cerebrovascular atherosclerosis: A 3.0T magnetic resonance imaging study.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China. Electronic address:

Reduction in cerebral blood flow (CBF), one of the major metrics for cerebral perfusion, is associated with many brain disorders. Therefore, early characterization of CBF prior to occurrence of symptoms is essential for prevention of cerebral ischemic disorders. We hypothesized that large artery atherosclerosis might be a potential indicator for decline in cerebral perfusion. Read More

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December 2018
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PF CAT Outcomes in Diabetic Lumbar Spine Surgical Patients.

Spine J 2018 Dec 12. Epub 2018 Dec 12.

University of Utah Department of Orthopaedic Surgery, 590 Wakara Way, Salt Lake City, UT 84108. Electronic address:

Background Context: Diabetes is a highly prevalent comorbid condition among patients undergoing spine surgery. Several studies have used legacy patient-reported outcome measures to implicate diabetes as a predictor of increased disability, pain, and decreased physical function and quality of life following spine surgery. The effect of diabetes on postoperative physical function has not yet been studied using the PROMIS Physical Function Computer Adaptive Test (PF CAT). Read More

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December 2018

Glucocorticoid receptor (NR3C1) gene polymorphisms are associated with age and blood parameters in Polish Caucasian nonagenarians and centenarians.

Exp Gerontol 2018 Dec 12. Epub 2018 Dec 12.

Mossakowski Medical Research Centre, PAS, Pawinskiego 5, 02-106 Warsaw, Poland; Medical Centre of Postgraduate Education, Marymoncka 99/103, 01-813 Warsaw, Poland. Electronic address:

Introduction: Polymorphism of the glucocorticoid receptor gene (NR3C1) may modify protein abundance or function and therefore disturb human homeostasis.

Methods: Variant frequencies of the three NR3C1 polymorphisms, rs2963154, rs10515522 and rs2918418, selected in silico as associated with longevity, was analyzed in 552 DNA samples from 95 to 106-year-old individuals and in 284 samples of cord blood DNA from newborns.

Results: Frequencies of the TT genotypes of rs2963154 and rs10515522, and of the rs291841 CC genotype, were higher in the long-lived study subjects (p = 0. Read More

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December 2018

Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis.

Ann Phys Rehabil Med 2018 Dec 13. Epub 2018 Dec 13.

576104 Manipal, Karnataka, India. Electronic address:

Background: Insulin resistance is a determining factor in the pathophysiology of type 2 diabetes mellitus (T2DM). Exercise is known to improve insulin resistance, but a systematic review of the literature is lacking.

Objective: This systematic review and meta-analysis focused on identifying evidence for the effectiveness of a structured exercise intervention program for insulin resistance in T2DM. Read More

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December 2018
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Tear Inflammatory Cytokines Analysis and Clinical Correlations in Diabetes and Non-diabetes with Dry Eye.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, 100191, China. Electronic address:

Purpose: To enhance the understanding of dry eye (DE) in diabetes by evaluating the ocular surface characteristics and the levels of tear inflammatory cytokines.

Design: Cross-sectional study.

Methods: Subjects were divided into four groups: 32 patients in diabetes with DE group; 24 patients in diabetes without DE group; 28 patients in non-diabetes with DE group and 29 volunteers in normal group. Read More

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December 2018
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