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    Binostril endoscopic transsphenoidal neurosurgery for pituitary adenomas: experience with 42 patients.
    Oncotarget 2017 Apr 9. Epub 2017 Apr 9.
    Department of Neurosurgery, The First People's Hospital of Yancheng, Yancheng, P R China.
    Here we review the technical aspects of our experience with the neuroendoscopic bilateral nostril (binostril) transsphenoidal approach for pituitary adenomas. A total of 42 patients were treated in our hospital from September 2013 to December 2015. Total tumor resection was completed in 31 cases, nearly full resection was achieved in 9 cases, and partial resection was achieved in 2 cases. Read More

    Clinical presentation and outcome of children with central diabetes insipidus associated with a self-limited or transient pituitary stalk thickening, diagnosed as infundibuloneurohypophysitis.
    Clin Endocrinol (Oxf) 2017 Apr 26. Epub 2017 Apr 26.
    Division of Pediatric Endocrinology, Vrije Universiteit Brussel, UZ Brussel Kinderziekenhuis, Brussels.
    Objective: Despite lymphocytic or autoimmune infundibuloneurohypophysitis (INH) is an increasingly recognized etiology in children with central diabetes insipidus, clinical data on epidemiology (clinical evolution, predisposing factors, complications), diagnosis and management of this entity are limited and mostly based on published case reports. The aim of this study was to gain a broader insight in the natural history of this disease by analyzing the clinical presentation, radiological pituitary stalk changes, associated autoimmunity and hormonal deficiencies in children with CDI and a self-limiting or transient stalk thickening (ST), diagnosed as autoimmune INH, during the last 15 years in four Belgian university hospitals.

    Design And Patients: The medical files of nine CDI patients with a ST at initial presentation and no signs of Langerhans cell histiocytosis or germinoma at presentation and/or during follow up of more than 1. Read More

    Late outcomes in children with Langerhans cell histiocytosis.
    Arch Dis Child 2017 Apr 25. Epub 2017 Apr 25.
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
    Introduction: Langerhans cell histiocytosis (LCH) is a rare disease with diverse clinical courses. Despite improvement in survival outcomes in the recent decades, sequelae of the disease remain a concern. This study aimed to provide information on the long-term outcomes in patients with LCH, particularly on the sequelae and any associated factors. Read More

    Presenting Symptoms of Pituitary Apoplexy.
    J Neurol Surg A Cent Eur Neurosurg 2017 Apr 24. Epub 2017 Apr 24.
    Department of Internal Medicine, Sotiria General Hospital of Chest Diseases, Athens, Greece.
    The classical term "pituitary apoplexy" (PA) describes a clinical syndrome usually characterized by abrupt onset of headache accompanied by neurologic and/or endocrinologic deterioration due to sudden expansion of a mass within the sella turcica as a result of hemorrhage or infarction within a pituitary tumor and adjacent pituitary gland. PA is a medical emergency and a difficult diagnosis to establish. Thus this article reviews the presenting symptoms of PA patients to help clinicians recognize or at least suspect this critical condition early on. Read More

    Clinical Outcome after Extended Endoscopic Endonasal Resection of Craniopharyngiomas: Two-institution Experience.
    World Neurosurg 2017 Apr 19. Epub 2017 Apr 19.
    Department of Neurological Surgery, Philadelphia, Pennsylvania. Electronic address:
    Background: The extended endoscopic endonasal approach (EEA) to the anterior cranial base is used for the resection of craniopharyngiomas.

    Objective: We present clinical experience and outcomes utilizing EEA for craniopharyngiomas.

    Methods: A total of 116 patients in two remote institutions were enrolled in this retrospective study. Read More

    Primary lymphocytic hypophysitis: clinical characteristics and treatment of 50 cases in a single centre in China over 18 years.
    Clin Endocrinol (Oxf) 2017 Apr 19. Epub 2017 Apr 19.
    Key Laboratory of Endocrinology of National Health and Family Planning Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730.
    Objective: Primary lymphocytic hypophysitis (LYH) is rare and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort.

    Design: A retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016. Read More

    Usefulness of anti-rabphilin-3A antibodies for diagnosing central diabetes insipidus in the third trimester of pregnancy.
    Endocr J 2017 Apr 14. Epub 2017 Apr 14.
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
    We report a 27-year-old pregnant woman with polyuria, polydipsia and headache in the third trimester of pregnancy. Hypernatremia (153 mEq/L), high plasma osmolality (300 mOsm/kgH2O) and low urinary osmolality (92 mOsm/kgH2O) were observed at the admission to our hospital. Plasma arginine vasopressin (AVP) level was inappropriately low (2. Read More

    Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene.
    Stem Cell Res 2017 Mar 24;19:37-42. Epub 2016 Dec 24.
    Department of Biomedicine, Aarhus University, Bartholins Allé 6, 8000 Aarhus C, Denmark.
    Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by variants in the arginine vasopressin (AVP) gene. Here we report the generation of induced pluripotent stem cells (iPSCs) from a 42-year-old man carrying an adFNDI causing variant in exon 1 of the AVP gene using lentivirus-mediated nuclear reprogramming. The iPSCs carried the expected variant in the AVP gene. Read More

    Endocrine Comorbidities in Patients with Psoriatic Arthritis: A Population-based Case-controlled Study.
    J Rheumatol 2017 Apr 15. Epub 2017 Apr 15.
    From the Department of Rheumatology, and the Department of Internal Medicine, and the Department of Community Medicine and Epidemiology, Carmel Medical Center; Bruce and Ruth Rappaport Faculty of Medicine Technion, Haifa; Chief Physician's Office, Central Headquarters, Clalit Health Services, Tel Aviv; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba, Israel. A. Haddad, MD, Department of Rheumatology, Carmel Medical Center; R.I. Ashkenazi, MD, Department of Internal Medicine, Carmel Medical Center; H. Bitterman, MD, Chief Physician's Office, Central Headquarters, Clalit Health Services, and Bruce and Ruth Rappaport Faculty of Medicine Technion; I. Feldhamer, MA, Chief Physician's Office, Central Headquarters, Clalit Health Services; S. Greenberg-Dotan, PhD, Chief Physician's Office, Central Headquarters, Clalit Health Services; I. Lavi, MA, MPH, Department of Community Medicine and Epidemiology, Carmel Medical Center; E. Batat, MBA, Chief Physician's Office, Central Headquarters, Clalit Health Services; I. Bergman, MD, Professor, Department of Internal Medicine, Carmel Medical Center; A.D. Cohen, PhD, MD, MPH, Chief Physician's Office, Central Headquarters, Clalit Health Services, and Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev; D. Zisman, MD, Department of Rheumatology, and Department of Community Medicine and Epidemiology, Carmel Medical Center. Dr. Haddad and Dr. Ashkenazi contributed equally to this work. Dr. Cohen and Dr. Zisman contributed equally to this work. Address correspondence to Dr. D. Zisman, Department of Rheumatology, Carmel Medical Center, 7 Michal St., Haifa 34362, Israel. E-mail: Accepted for publication February 21, 2017.
    Objective: To investigate endocrine comorbidities in patients with psoriatic arthritis (PsA).

    Methods: A retrospective, cross-sectional study was performed with the database of Clalit Health Services, the largest healthcare provider in Israel, between 2002 and 2014. Patients with PsA were identified and matched by age and sex to healthy controls. Read More

    Complete endoscopic resection of a pituitary stalk epidermoid cyst using a combined infrasellar interpituitary and suprasellar endonasal approach: case report.
    J Neurosurg 2017 Apr 14:1-7. Epub 2017 Apr 14.
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and.
    Intracranial epidermoid cysts are benign lesions of epithelial origin that most frequently present with symptoms of mass effect. Although they are often associated with a high rate of residual tumor and recurrence, maximal safe resection usually leads to good outcomes. The authors report a complete resection of an uncommon pituitary stalk epidermoid cyst with intrasellar extension using a combined suprasellar and infrasellar interpituitary, endoscopic endonasal transsphenoidal approach. Read More

    Development and Diseases of the Collecting Duct System.
    Results Probl Cell Differ 2017 ;60:165-203
    Department of Regenerative and Cancer Cell Biology, Albany Medical College, MC-165, 47 New Scotland Avenue, Albany, NY, 12208, USA.
    The collecting duct of the mammalian kidney is important for the regulation of extracellular volume, osmolarity, and pH. There are two major structurally and functionally distinct cell types: principal cells and intercalated cells. The former regulates Na(+) and water homeostasis, while the latter participates in acid-base homeostasis. Read More

    Pulmonary langerhans cell histiocytosis case with diabetes insipidus and tuberculosis.
    Niger J Clin Pract 2017 Apr;20(4):503-506
    Pamukkale University, Medicine Faculty, Pathology Department, Denizli, Turkey.
    A 19-year-old male patient was observed due to having central diabetes insipidus (DI) for five years. He had a history of smoking 5-10 cigarettes a day for two years, but stopped smoking from the last month. The computerized tomography revealed thin-walled cystic lesions in different sizes more dominantly in the upper lobes and consolidated areas in the left upper and lower lobes. Read More

    Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus.
    JCI Insight 2017 Apr 6;2(7):e91042. Epub 2017 Apr 6.
    InterPrET Center, Department of Biomedicine, Aarhus University, Aarhus, Denmark.
    Psychiatric patients treated with lithium (Li(+)) may develop nephrogenic diabetes insipidus (NDI). Although the etiology of Li(+)-induced NDI (Li-NDI) is poorly understood, it occurs partially due to reduced aquaporin-2 (AQP2) expression in the kidney collecting ducts. A mechanism postulated for this is that Li(+) inhibits adenylyl cyclase (AC) activity, leading to decreased cAMP, reduced AQP2 abundance, and less membrane targeting. Read More

    Can takotsubo cardiomyopathy be diagnosed by autopsy? Report of a presumed case presenting as cardiac rupture.
    BMC Clin Pathol 2017 5;17. Epub 2017 Apr 5.
    Departments of Medicine, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L'Assomption, Montreal, Quebec H1T 2M4 Canada.
    Background: Takostsubo (stress) cardiomyopathy (TC) is a clinical syndrome featuring transient left ventricular dysfunction and wall-motion abnormalities, usually following emotional or physical stress. The diagnosis of TC depends on fulfillment of multiple clinical criteria. Although the pathogenesis has not been firmly established, myocardial cathecholamine toxicity is thought to represent a primary mechanism. Read More

    Critical Care Air Transport Team severe traumatic brain injury short-term outcomes during flight for Operation Iraqi Freedom/Operation Enduring Freedom.
    J R Army Med Corps 2017 Apr 6. Epub 2017 Apr 6.
    Emergency Medicine, Duke University Medical Center, Durham, North Carolina, USA.
    Introduction: Our understanding of the expertise and equipment required to air transport injured soldiers with severe traumatic brain injuries (TBIs) continue to evolve.

    Methods: We conducted a retrospective chart review of characteristics, interventions required and short-term outcomes of patients with severe TBI managed by the US Air Force Critical Care Air Transport Teams (CCATTs) deployed in support of Operation Iraqi Freedom and Operation Enduring Freedom between 1 June 2007 and 31 August 2010. Patients were cared for based on guidelines given by the Brain Trauma Foundation and the Joint Theater Trauma System by non-neurosurgeon physicians with dedicated neurocritical care training. Read More

    [Atypical presentation of a breast cancer pituitary metastasis].
    Rev Med Liege 2016 Jul;71(7-8):332-335
    Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, Saint Priest en Jarez, 42271 France.
    Pituitary metastasis occur in 1-5 % of patients with cancer. We report the discovery of a unique pituitary metastasis of breast cancer. A 67 years old woman was treated in 2003 for local adenocarcinoma. Read More

    Current best practice in the management of patients after pituitary surgery.
    Ther Adv Endocrinol Metab 2017 Mar 1;8(3):33-48. Epub 2017 Mar 1.
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University, 1830 East Monument Street #333, Baltimore, MD 21287, USA.
    Sellar and parasellar masses are a common finding, and most of them are treated surgically via transsphenoidal approach. This type of surgery has revolutionized the approach to several hypothalamic-pituitary diseases and is usually effective, and well-tolerated by the patient. However, given the complex anatomy and high density of glandular, neurological and vascular structures in a confined space, transsphenoidal surgery harbors a substantial risk of complications. Read More

    Renal compensatory adaptation for water handling in a patient with adipsic diabetes insipidus after clipping of a ruptured aneurysm of the anterior communicating artery
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    Clin Nephrol 2017 Apr 4. Epub 2017 Apr 4.
    A 38-year-old Japanese man who had undergone clipping surgery for a ruptured aneurysm of the anterior communicating artery 2 days prior, suddenly developed refractory hypernatremia (serum sodium (Na) 156 - 162 mmol/L). Symptoms included low plasma vasopressin, fluctuating urine osmolality (120 - 710 mOsm/kg) and lack of thirst, all suggesting adipsic diabetes insipidus (ADI). Hypernatremia was corrected by scheduled water intake with desmopressin administration. Read More

    Langerhans cell histiocytosis masquerading as acute appendicitis: Case report and review.
    World J Gastrointest Endosc 2017 Mar;9(3):139-144
    Mohammad M Karimzada, Daniel DeUgarte, Dennis Y Kim, Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA 90502, United States.
    Langerhans cell histiocytosis (LCH) is a rare syndrome characterized by unifocal, multifocal unisystem, or disseminated/multi-system disease that commonly involves the bone, skin, lymph nodes, pituitary, or sometimes lung (almost exclusively in smokers) causing a variety of symptoms from rashes and bone lesions to diabetes insipidus or pulmonary infiltrates. We present a previously unreported case of gastrointestinal LCH as well as a novel characteristic lesion affecting the colon of a young woman who presented with signs and symptoms mimicking acute on chronic appendicitis. Immunohistochemical analysis of appendectomy specimen and nodular specimens on colonoscopy demonstrated S-100, CD1a, and langerin reactivity. Read More

    Very long-term sequelae of craniopharyngioma.
    Eur J Endocrinol 2017 Jun 21;176(6):755-767. Epub 2017 Mar 21.
    Section EndocrinologyDepartment of Medicine, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, the Netherlands.
    Objective: Studies investigating long-term health conditions in patients with craniopharyngioma are limited by short follow-up durations and generally do not compare long-term health effects according to initial craniopharyngioma treatment approach. In addition, studies comparing long-term health conditions between patients with childhood- and adult-onset craniopharyngioma report conflicting results. The objective of this study was to analyse a full spectrum of long-term health effects in patients with craniopharyngioma according to initial treatment approach and age group at craniopharyngioma presentation. Read More

    Operative Strategies to Minimize Complications Following Resection of Pituitary Macroadenomas.
    J Neurol Surg B Skull Base 2017 Apr 7;78(2):184-190. Epub 2016 Dec 7.
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States.
    Introduction We sought to identify factors associated with increased length of stay (LOS) and morbidity in patients undergoing resection of pituitary macroadenomas. Methods We reviewed records of 203 consecutive patients who underwent endoscopic endonasal resection of a pituitary macroadenoma (mean age = 55.7 [16-88]) years, volume = 11. Read More

    Extent of Resection, Visual and Endocrinological Outcomes for Endoscopic Endonasal Surgery for Recurrent Pituitary Adenomas.
    World Neurosurg 2017 Mar 9. Epub 2017 Mar 9.
    Department of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut Street, 3rd floor Philadelphia, PA 19107; Department of Otolaryngology, Thomas Jefferson University 925 Chestnut Street, 6th floor, Philadelphia, PA 19107. Electronic address:
    Objective: To assess outcomes after endoscopic endonasal surgery for recurrent or residual pituitary adenomas.

    Methods: We retrospectively analyzed 61 patients from 2009 - 2016 that underwent endoscopic endonasal surgery for recurrent or residual pituitary adenomas after prior microscopic or endoscopic transphenoidal operation.

    Results: Prior surgical approach was endoscopic endonasal in 55. Read More

    Prognosis of pituitary adenomas in the early 1970s and today-Is there a benefit of modern surgical techniques and treatment modalities?
    Clin Neurol Neurosurg 2017 Mar 2;156:4-10. Epub 2017 Mar 2.
    Klinik für Neurochirurgie, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.
    Objective: Neurosurgical techniques for the treatment of sellar pathologies have been evolving continuously over the last decades. Additionally to the innovation of approaches and surgical techniques, this progress yielded to the application of modern intraoperative surgical tools as well as peri- and intraoperative imaging. Until now, no long-term analysis of the impact of new therapy concepts on the patient's outcome exists. Read More

    Efficacy of endoscopic endonasal transsphenoidal surgery for Cushing's disease in 230 patients with positive and negative MRI.
    Acta Neurochir (Wien) 2017 Mar 9. Epub 2017 Mar 9.
    Department of Neurosurgery, Hôpital Foch, Suresnes, France.
    Object: The primary objective was to assess the remission rate, and the secondary objectives were to evaluate the early complications and recurrence rate and to define the predictive factors for the remission and recurrence rates.

    Patients And Methods: This prospective single-center study included 230 consecutive patients, operated on by a single surgeon for Cushing's disease via a transsphenoidal endoscopic endonasal approach, over a 6-year period (2008-2013). The patients included in this series were all adults (>18 years of age), who presented with clinical and biological characteristics of Cushing's disease confirmed based on dedicated MRI pituitary imaging. Read More

    Desmopressin for nocturia in adults.
    • Authors:
    Drug Ther Bull 2017 Mar;55(3):30-32
    Desmopressin has been used for many years in the treatment of diabetes insipidus, nocturnal enuresis (involuntary urination while asleep) and nocturia associated with multiple sclerosis (in adults aged up to 65 years); it has also been recommended in certain circumstances for the treatment of nocturia in men and women (previously, an unlicensed use).(1,2) Recently, a new brand of desmopressin sublingual tablet (lyophilisate-an orally disintegrating tablet; Noqdirna-Ferring) has been licensed for use in adults of any age for the treatment of nocturia due to idiopathic nocturnal polyuria.(3,4) The tablets contain a lower dose of desmopressin than was previously available. Read More

    Value of Renal Biopsy in Diagnosing Infantile Nephropathic Cystinosis Associated With Secondary Nephrogenic Diabetes Insipidus.
    Pediatr Dev Pathol 2017 Jan-Feb;20(1):72-75
    3 Division of Pediatric Pathology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
    Cystinosis is the most common cause of inherited renal Fanconi syndrome in young children, and typically presents with laboratory findings of a proximal tubulopathy and corneal crystals by one year of age. We describe here renal biopsy findings in a 20-month-old patient with an atypical presentation of distal renal tubular acidosis, diabetes insipidus, and the absence of corneal crystals. Although renal biopsy is usually not necessary to establish the diagnosis of cystinosis, when the patient presents with atypical signs and symptoms, a renal biopsy may be extremely valuable. Read More

    Rare presentation of Wegener's granulomatosis in the pituitary gland: Case report and literature review.
    Int J Surg Case Rep 2017 Feb 20;33:24-26. Epub 2017 Feb 20.
    Department of Neurosurgery, The Alfred Hospital,55 Commercial Road, Prahran, VIC 3181, Australia. Electronic address:
    Introduction: Wegener's granulomatosis (WG) is a systemic vasculitis that can affect a variety of organs including ear, nose and throat, lungs and kidneys. However WG is unusual in the pituitary and rare in the central nervous system.

    Presentation Of Case: A 56-year-old male with likely WG presented with polyuria and polydipsia despite six months of conservative medical management. Read More

    A novel heterozygous mutation of the WFS1 gene leading to constitutive endoplasmic reticulum stress is the cause of Wolfram syndrome.
    Pediatr Diabetes 2017 Mar 8. Epub 2017 Mar 8.
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Background: Wolfram syndrome (WS) is a disorder characterized by the association of insulin-dependent diabetes mellitus (DM), diabetes insipidus, deafness, and optic nerve atrophy. WS is caused by WFS1 mutations encoding WFS1 protein expressed in endoplasmic reticulum (ER). During ER protein synthesis, misfolded and unfolded proteins accumulate, known as "ER stress". Read More

    Jean Camus and Gustave Roussy: pioneering French researchers on the endocrine functions of the hypothalamus.
    Pituitary 2017 Mar 6. Epub 2017 Mar 6.
    Department of Neurosurgery, La Princesa University Hospital, Madrid, Spain.
    At the beginning of the twentieth century, the hypothalamus was known merely as an anatomical region of the brain lying beneath the thalamus. An increasing number of clinicopathological reports had shown the association of diabetes insipidus and adiposogenital dystrophy (Babinski-Fröhlich's syndrome), with pituitary tumors involving the infundibulum and tuber cinereum, two structures of the basal hypothalamus. The French physicians Jean Camus (1872-1924) and Gustave Roussy (1874-1948) were the first authors to undertake systematic, controlled observations of the effects of localized injuries to the basal hypothalamus in dogs and cats by pricking the infundibulo-tuberal region (ITR) with a heated needle. Read More

    Diabetes Insipidus.
    Adv Exp Med Biol 2017 ;969:213-225
    Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.
    Disruption of water and electrolyte balance is frequently encountered in clinical medicine. Regulating water metabolism is critically important. Diabetes insipidus (DI) presented with excessive water loss from the kidney is a major disorder of water metabolism. Read More

    Idiopathic thrombocytopenic purpura in childhood, Langerhans cell histiocytosis in adulthood: More than a chance association?
    Med J Malaysia 2017 Feb;72(1):50-52
    Putrajaya Hospital, Department of Medicine, Endocrine Unit, Malaysia.
    Described herein, a case of Langerhans cell histiocytosis (LCH) in an adult with Idiopathic Thrombocytopenic Purpura (ITP) diagnosed at age ten. She presented with cranial diabetes insipidus, later developed hypogonadotrophic hypogonadism and multiple cervical lympadenopathy from which histopathology of excisional biopsy confirmed LCH. Magnetic resonance imaging showed thickened pituitary stalk. Read More

    Outcome of Radical Surgical Resection for Craniopharyngioma with Hypothalamic Preservation: A Single-Center, Retrospective Study of 1054 Patients.
    World Neurosurg 2017 Feb 27. Epub 2017 Feb 27.
    Department of Neurosurgery, Fu Xing Hospital, Capital Medical University, Beijing, China 100038.
    Objective: A retrospective review of the surgical outcome for patients with craniopharyngioma (CP) treated in a single neurosurgical center with surgical resection using visualization to ensure hypothalamic preservation.

    Methods: The study included 1054 patients. Prior to 2003, a pterional cranial approach was preferred for 78% of patients; after 2004, the unifrontal basal interhemispheric approach (UBIA) was performed in 79. Read More

    Rapid exacerbation of lymphocytic infundibuloneurohypophysitis.
    Medicine (Baltimore) 2017 Mar;96(9):e6034
    aDepartment of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan bDepartment of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan. cDepartment of Neurosurgery, Graduate School of Medicine, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan.
    Rationale: Lymphocytic hypophysitis is a relatively rare autoimmune disease defined by lymphocytic infiltration to the pituitary. Its rarity and wide spectrum of clinical manifestations make clarification of the pathology difficult. Here, we describe a case we examined from the primary diagnosis to final discharge, showing the serial progression of lymphocytic infundibuloneurohypophysitis (LINH) to panhypopituitarism with extrapituitary inflammatory invasion in a short period, and responding favorably to high-dose glucocorticoid treatment. Read More

    Restored vision in a young dog following corticosteroid treatment of presumptive hypophysitis.
    BMC Vet Res 2017 Feb 28;13(1):63. Epub 2017 Feb 28.
    Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, EH25 9RG, UK.
    Background: Hypophysitis is an umbrella term for a group of disorders involving inflammation of the pituitary gland. A rare occurrence in humans, hypophysitis can produce a range of clinical signs including (but not limited to) visual deficits and diabetes insipidus. Only five cases of canine hypophysitis exist in the literature, all presenting in mature dogs with no visual deficits and a grave outcome. Read More

    Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus.
    Nat Commun 2017 Feb 24;8:14577. Epub 2017 Feb 24.
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
    NF-E2-related factor-2 (Nrf2) regulates cellular responses to oxidative and electrophilic stress. Loss of Keap1 increases Nrf2 protein levels, and Keap1-null mice die of oesophageal hyperkeratosis because of Nrf2 hyperactivation. Here we show that deletion of oesophageal Nrf2 in Keap1-null mice allows survival until adulthood, but the animals develop polyuria with low osmolality and bilateral hydronephrosis. Read More

    Prasugrel suppresses development of lithium-induced nephrogenic diabetes insipidus in mice.
    Purinergic Signal 2017 Feb 23. Epub 2017 Feb 23.
    Department of Internal Medicine and Center on Aging, University of Utah Health Sciences Center, Veterans Affairs Salt Lake City, Health Care System, 500 Foothill Drive (151M), Salt Lake City, UT, 84148, USA.
    Previously, we localized ADP-activated P2Y12 receptor (R) in rodent kidney and showed that its blockade by clopidogrel bisulfate (CLPD) attenuates lithium (Li)-induced nephrogenic diabetes insipidus (NDI). Here, we evaluated the effect of prasugrel (PRSG) administration on Li-induced NDI in mice. Both CLPD and PRSG belong to the thienopyridine class of ADP receptor antagonists. Read More

    Microscopic Transnasal Transsphenoidal Surgery for Pediatric Pituitary Adenomas.
    J Craniofac Surg 2017 Feb 22. Epub 2017 Feb 22.
    Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Microscopic transnasal transsphenoidal surgery (MTTS) has been a time-confirmed effective treatment for pituitary adenomas; however, the data supporting its use in pediatric patients is limited. In this study, the authors summarize the authors' 5-year experience of pituitary adenomectomy via MTTS in a pediatric population. The authors retrospectively reviewed the medical records of 35 patients aged ≤18 years who underwent microscopic transnasal transsphenoidal approach for pituitary adenomas between January 2011 and December 2015. Read More

    Aliskiren Increases Aquaporin-2 Expression and Attenuates Lithium-induced Nephrogenic Diabetes Insipidus.
    Am J Physiol Renal Physiol 2017 Feb 22:ajprenal.00553.2016. Epub 2017 Feb 22.
    Sun Yat-sen Univ, Zhongshan School of Medicine
    The direct renin inhibitor aliskiren has been shown to retain and persist in medullary collecting ducts even after treatment was discontinued, suggesting a new mechanism of action for this drug. The purpose of the present study was to investigate whether aliskiren regulates renal aquaporin expression in the collecting ducts and improves urinary concentrating defect induced by lithium in mice. The mice were either fed with normal chow or LiCl diet (40mM/kg dry food/day for 4 days and 20mM/kg dry food/day for last 3 days) for seven days. Read More

    Transfrontal and Transsphenoidal Approaches to Pediatric Craniopharyngioma: A National Perspective.
    Pediatr Neurosurg 2017 Feb 23. Epub 2017 Feb 23.
    Department of Neurosurgery, Oregon Health and Sciences University, Portland, OR, USA.
    Introduction: This study compared transsphenoidal (TS) and transfrontal (TF) approaches to craniopharyngioma utilizing a national database.

    Methods: The Kids' Inpatient Database (2003, 2006, and 2009) was surveyed for patients with a diagnosis of craniopharyngioma who underwent a subset of surgical interventions to compare TS and TF surgery. Demographics, hospital variables, and complications/comorbidities were analyzed with multivariate regression. Read More

    Longitudinal Extensive Transverse Myelitis and Central Diabetes Insipidus: A Severe Flare of Systemic Lupus Erythematosus.
    J Clin Rheumatol 2017 Mar;23(2):122-124
    Division of Rheumatology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil Division of Rheumatology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil Division of Neurology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil Division of Rheumatology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil Division of Rheumatology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil,

    CENTRAL DIABETES INSIPIDUS: CLINICAL CHARACTERISTICS AND LONG-TERM COURSE IN A LARGE COHORT OF ADULTS.
    Endocr Pract 2017 Feb 22. Epub 2017 Feb 22.
    From: 1Endocrine Institute, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
    Purpose Central diabetes insipidus (CDI) is a rare heterogeneous condition with various underlying causes. This study sought to increase the still-limited data on the clinical characteristics and long-term course in adults diagnosed with CDI. Methods Data on demographics, presentation, imaging findings, affected pituitary axes, treatment, and complications were collected retrospectively from the files of 70 adult patients with CDI followed at a referral endocrine clinic. Read More

    Endoplasmic Reticulum (ER) Stress and Endocrine Disorders.
    Int J Mol Sci 2017 Feb 11;18(2). Epub 2017 Feb 11.
    Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo 183-8561, Japan.
    The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Neuroendocrine surveillance and management of neurosurgical patients.
    Eur J Endocrinol 2017 May 13;176(5):R217-R233. Epub 2017 Feb 13.
    Academic Department of EndocrinologyBeaumont Hospital/RCSI Medical School, Dublin, Ireland
    Advances in the management of traumatic brain injury, subarachnoid haemorrhage and intracranial tumours have led to improved survival rates and an increased focus on quality of life of survivors. Endocrine sequelae of the acute brain insult and subsequent neurosurgery, peri-operative fluid administration and/or cranial irradiation are now well described. Unrecognised acute hypopituitarism, particularly ACTH/cortisol deficiency and diabetes insipidus, can be life threatening. Read More

    Therapeutics for Equine Endocrine Disorders.
    Vet Clin North Am Equine Pract 2017 Apr 9;33(1):127-139. Epub 2017 Feb 9.
    Liphook Equine Hospital, Liphook, Hampshire GU30 7JG, UK. Electronic address:
    Equine endocrine disease is commonly encountered by equine practitioners. Pituitary pars intermedia dysfunction (PPID) and equine metabolic syndrome (EMS) predominate. The most logical therapeutic approach in PPID uses dopamine agonists; pergolide mesylate is the most common. Read More

    Vasospasm after Craniopharyngioma surgery: Can we prevent it?
    World Neurosurg 2017 Feb 8. Epub 2017 Feb 8.
    Dept of Endocrinology, PGIMER, Chandigarh, India.
    Background: Vasospasm following craniopharyngioma surgery, though rare, has been reported. Hypotheses regarding possible causative factors including major vessel handling during surgery and tumour cyst fluid spillage do not explain vasospasm occurring in the late post operative period. We have attempted to look into the probable pathogenic mechanisms of this complication and measures to prevent it. Read More

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