Search our Database of Scientific Publications and Authors

I’m looking for a

    9921 results match your criteria Diabetes Insipidus

    1 OF 199

    Microscopic Transnasal Transsphenoidal Surgery for Pediatric Pituitary Adenomas.
    J Craniofac Surg 2017 Feb 22. Epub 2017 Feb 22.
    Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Microscopic transnasal transsphenoidal surgery (MTTS) has been a time-confirmed effective treatment for pituitary adenomas; however, the data supporting its use in pediatric patients is limited. In this study, the authors summarize the authors' 5-year experience of pituitary adenomectomy via MTTS in a pediatric population. The authors retrospectively reviewed the medical records of 35 patients aged ≤18 years who underwent microscopic transnasal transsphenoidal approach for pituitary adenomas between January 2011 and December 2015. Read More

    Aliskiren Increases Aquaporin-2 Expression and Attenuates Lithium-induced Nephrogenic Diabetes Insipidus.
    Am J Physiol Renal Physiol 2017 Feb 22:ajprenal.00553.2016. Epub 2017 Feb 22.
    Sun Yat-sen Univ, Zhongshan School of Medicine
    The direct renin inhibitor aliskiren has been shown to retain and persist in medullary collecting ducts even after treatment was discontinued, suggesting a new mechanism of action for this drug. The purpose of the present study was to investigate whether aliskiren regulates renal aquaporin expression in the collecting ducts and improves urinary concentrating defect induced by lithium in mice. The mice were either fed with normal chow or LiCl diet (40mM/kg dry food/day for 4 days and 20mM/kg dry food/day for last 3 days) for seven days. Read More

    Ophthalmologic findings in fifteen patients with Wolfram syndrome.
    Eur J Ophthalmol 2002 Mar - Apr 2002;12(2):84-88
    Ophthalmology Department, Jordan University Hospital, Amman.
    Purpose: To look for ophthalmologic abnormalities in 15 patients with Wolfram syndrome, also known as DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness).

    Methods: Fifteen patients from four inbred families diagnosed as having Wolfram syndrome at the National Center for Diabetes, Endocrinology and Genetics, in Amman, Jordan, were evaluated ophthalmologically. Their examination included best-corrected visual acuity, color vision testing, pupillary light reflexes, slit-lamp biomicroscopy and fundus examination. Read More

    Transfrontal and Transsphenoidal Approaches to Pediatric Craniopharyngioma: A National Perspective.
    Pediatr Neurosurg 2017 Feb 23. Epub 2017 Feb 23.
    Department of Neurosurgery, Oregon Health and Sciences University, Portland, OR, USA.
    Introduction: This study compared transsphenoidal (TS) and transfrontal (TF) approaches to craniopharyngioma utilizing a national database.

    Methods: The Kids' Inpatient Database (2003, 2006, and 2009) was surveyed for patients with a diagnosis of craniopharyngioma who underwent a subset of surgical interventions to compare TS and TF surgery. Demographics, hospital variables, and complications/comorbidities were analyzed with multivariate regression. Read More

    Longitudinal Extensive Transverse Myelitis and Central Diabetes Insipidus: A Severe Flare of Systemic Lupus Erythematosus.
    J Clin Rheumatol 2017 Mar;23(2):122-124
    Division of Rheumatology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil Division of Rheumatology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil Division of Neurology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil Division of Rheumatology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil Division of Rheumatology, Hospital das Clínicas, da Faculdade de Medicina, da Universidade de São Paulo, São Paulo, Brazil,

    Endocr Pract 2017 Feb 22. Epub 2017 Feb 22.
    From: 1Endocrine Institute, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
    Purpose Central diabetes insipidus (CDI) is a rare heterogeneous condition with various underlying causes. This study sought to increase the still-limited data on the clinical characteristics and long-term course in adults diagnosed with CDI. Methods Data on demographics, presentation, imaging findings, affected pituitary axes, treatment, and complications were collected retrospectively from the files of 70 adult patients with CDI followed at a referral endocrine clinic. Read More

    Endoplasmic Reticulum (ER) Stress and Endocrine Disorders.
    Int J Mol Sci 2017 Feb 11;18(2). Epub 2017 Feb 11.
    Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo 183-8561, Japan.
    The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Neuroendocrine surveillance and management of neurosurgical patients (non-pituitary).
    Eur J Endocrinol 2017 Feb 13. Epub 2017 Feb 13.
    C Thompson, Academic Department of Diabetes and Endocrinology, Beaumont Hospital/RCSI Medical School, Dublin 9, D9, Ireland
    Advances in the management of traumatic brain injury, subarachnoid haemorrhage and intracranial tumours have led to improved survival rates and an increased focus on quality of life of survivors. Endocrine sequelae of the acute brain insult and subsequent neurosurgery, peri-operative fluid administration and/or cranial irradiation are now well described. Unrecognized acute hypopituitarism, particularly ACTH/cortisol deficiency and diabetes insipidus, can be life-threatening. Read More

    Therapeutics for Equine Endocrine Disorders.
    Vet Clin North Am Equine Pract 2017 Feb 9. Epub 2017 Feb 9.
    Liphook Equine Hospital, Liphook, Hampshire GU30 7JG, UK. Electronic address:
    Equine endocrine disease is commonly encountered by equine practitioners. Pituitary pars intermedia dysfunction (PPID) and equine metabolic syndrome (EMS) predominate. The most logical therapeutic approach in PPID uses dopamine agonists; pergolide mesylate is the most common. Read More

    Vasospasm after Craniopharyngioma surgery: Can we prevent it?
    World Neurosurg 2017 Feb 8. Epub 2017 Feb 8.
    Dept of Endocrinology, PGIMER, Chandigarh, India.
    Background: Vasospasm following craniopharyngioma surgery, though rare, has been reported. Hypotheses regarding possible causative factors including major vessel handling during surgery and tumour cyst fluid spillage do not explain vasospasm occurring in the late post operative period. We have attempted to look into the probable pathogenic mechanisms of this complication and measures to prevent it. Read More

    A case of central diabetes insipidus after ketamine infusion during an external to internal carotid artery bypass.
    J Clin Anesth 2017 Feb 25;36:72-75. Epub 2016 Nov 25.
    Department of Anesthesiology, Tulane Medical Center, New Orleans, LA, USA.
    Study Objective: We report the first teenage case of ketamine-induced transient central diabetes insipidus.

    Case Summary: The patient was an 18-year-old woman with moyamoya disease undergoing an external carotid to internal carotid bypass and given a low-dose ketamine infusion. After approximately 2 hours in the supine position, with 0. Read More

    Pure endoscopic management of epileptogenic hypothalamic hamartomas.
    Neurosurg Rev 2017 Feb 7. Epub 2017 Feb 7.
    Neurosurgery Department, Strasbourg University Hospital, Strasbourg, France.
    Hypothalamic hamartomas (HH) are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Their usual clinical presentation is characterized by gelastic/dacrystic seizures which often become pharmaco-resistant and progress to secondary focal/generalized intractable epilepsy causing mostly in children cognitive and behavioral problems (particularly in cases of progressive epileptic encephalopathy) and precocious puberty. Whereas gelastic seizures can be surgically controlled either by resection of the lesion or disconnection (tissue-destructive) procedures, aimed at functionally prevent the spreading of the epileptic burst; generalized seizures tend to respond better to HH excision rather than isolated neocortical resections, which generally fail to control them. Read More

    Case Report of a Primary Pituitary Abscess and Systematic Literature Review of Pituitary Abscess with a Focus on Patient Outcomes.
    World Neurosurg 2017 Jan 30. Epub 2017 Jan 30.
    Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York USA; Department of Neurosurgery, Buffalo General Medical Center and Gates Vascular Institute, Kaleida Health, Buffalo, New York, USA. Electronic address:
    Background: Pituitary abscess is a rare but potentially life-threatening condition with an incidence of 0.2-1.1% of operative pituitary lesions. Read More

    Clinical predictors of diabetes insipidus after transcranial surgery for pituitary adenoma.
    World Neurosurg 2017 Jan 30. Epub 2017 Jan 30.
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China; Beijing Key Laboratory of Brain Tumor, Beijing, China. Electronic address:
    Objective: Diabetes insipidus (DI) is a well-known complication of transsphenoidal pituitary adenoma surgery. However, the risk factors for DI after transcranial surgery have not been clarified. In this study, the clinical parameters for predicting DI after transcranial surgery were investigated. Read More

    Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus.
    Kidney Int 2017 Jan 27. Epub 2017 Jan 27.
    Systems Biology Center, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Epithelial Systems Biology Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. Electronic address:
    Hypercalcemia can cause renal dysfunction such as nephrogenic diabetes insipidus (NDI), but the mechanisms underlying hypercalcemia-induced NDI are not well understood. To elucidate the early molecular changes responsible for this disorder, we employed mass spectrometry-based proteomic analysis of inner medullary collecting ducts (IMCD) isolated from parathyroid hormone-treated rats at onset of hypercalcemia-induced NDI. Forty-one proteins, including the water channel aquaporin-2, exhibited significant changes in abundance, most of which were decreased. Read More

    Nephrogenic diabetes insipidus.
    Curr Opin Pediatr 2017 Jan 27. Epub 2017 Jan 27.
    aUCL Institute of Child Health and Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK bDepartments of Medicine, Pharmacology and Physiology, Université de Montréal cUnité de recherche clinique, Centre de recherche et Service de néphrologie, Hôpital du Sacré-Coeur de Montreal, Montreal, Quebec, Canada.
    Purpose Of Review: In nephrogenic diabetes insipidus (NDI), the kidney is unable to concentrate urine despite elevated concentrations of the antidiuretic hormone arginine-vasopressin. In congenital NDI, polyuria and polydipsia are present from birth and should be immediately recognized to avoid severe episodes of dehydration. Unfortunately, NDI is still often recognized late after a 'diagnostic odyssey' involving false leads and dangerous treatments. Read More

    Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus.
    Saudi Med J 2017 Feb;38(2):196-200
    Department of Intensive Care, College of Medicine, King Saud bin Abdul-Aziz University for Health Sciences, King Abdul-Aziz Medical City, National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia. E-mail.
    The Middle East respiratory syndrome corona virus (MERS-CoV) is a novel positive sense singlestranded ribonucleic acid virus of the genus Beta corona virus. This virus was first isolated from a patient who died from severe respiratory illness in June 2012 in Jeddah, Kingdom of Saudi Arabia. We describe an unusual case of a 42 year old healthcare worker who was admitted to our Intensive Care Unit (ICU)King Abdul-Aziz Medical City, with MERS-CoV and severe acute respiratory distress Syndrome and developed a sudden-onset diabetes insipidus and spontaneous massive intracranial hemorrhage with intra-ventricular extension and tonsillar herniation. Read More

    Wolfram Syndrome. Case report.
    Pediatr Endocrinol Diabetes Metab 2016 ;22(1):39-42
    Department of Pediatrics, Hematology, Oncology and Diabetology, Medical University in Łódź, Poland.
    Wolfram syndrome is a rare neurodegenerative and genetic disorder, characterized by insulin-dependent diabetes mellitus, caused by non-autoimmune loss of β cells, as well as optic atrophy; the disease is also known as DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness). Patients that demonstrate diabetes mellitus are also affected by: optic atrophy in the first decade of their life, diabetes insipidus and sensorineural deafness in the second decade, and urinary tract and neurological abnormalities in the third decade of their life. Patients with Wolfram syndrome usually die due to central respiratory failures caused by brain stem atrophy in their third or at the beginning of their fourth decade of life. Read More

    Vasopressin Bolus Protocol Compared to Desmopressin (DDAVP) for Managing Acute, Postoperative Central Diabetes Insipidus and Hypovolemic Shock.
    Case Rep Endocrinol 2017 3;2017:3052102. Epub 2017 Jan 3.
    Department of Neurology, University of Missouri, Columbia, MO, USA.
    Introduction. Management of postoperative central diabetes insipidus (DI) can be challenging from changes in volume status and serum sodium levels. We report a case successfully using a dilute vasopressin bolus protocol in managing hypovolemic shock in acute, postoperative, central DI. Read More

    Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation stages in craniopharyngioma.
    Oncol Lett 2017 Jan 22;13(1):250-252. Epub 2016 Nov 22.
    Department of Neurosurgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China.
    Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation periods in craniopharyngioma cases were examined. Twenty patients who underwent tumor resection from January 2012 to January 2015 were included in the study. We monitored factors related to endocrine changes and hormone substitution treatment during pre- and post-operation periods. Read More

    Amyloid-like aggregation of provasopressin in diabetes insipidus and secretory granule sorting.
    BMC Biol 2017 Jan 26;15(1). Epub 2017 Jan 26.
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland.
    Background: Aggregation of peptide hormone precursors in the trans-Golgi network is an essential process in the biogenesis of secretory granules in endocrine cells. It has recently been proposed that this aggregation corresponds to the formation of functional amyloids. Our previous finding that dominant mutations in provasopressin, which cause cell degeneration and diabetes insipidus, prevent native folding and produce fibrillar aggregates in the endoplasmic reticulum (ER) might thus reflect mislocalized amyloid formation by sequences that evolved to mediate granule sorting. Read More

    An unusual pituitary stalk lesion: What is the place of surgery?
    Neurochirurgie 2016 Dec 26;62(6):339-343. Epub 2016 Oct 26.
    Service de neurochirurgie, hôpital Hautepierre, hôpitaux universitaires de Strasbourg, 1, avenue Molière, 67098 Strasbourg, France. Electronic address:
    Background: Sellar and suprasellar primary melanocytic tumors are exceptional occurrences. Besides the difficulty of differential diagnosis between a primary and secondary lesion, treatment of these pathologies is still unclear and controversial.

    Case Report: We describe the case of a 36-year-old woman with no relevant previous medical history who presented with 1 month history of diabetes insipidus, blurred vision and generalized weakness; a brain MRI disclosed an atypical pituitary stalk lesion; initially the tumor was biopsied through an endonasal endoscopic approach that revealed a melanocytic tumor; the patient was afterwards managed by a second stage extended endonasal endoscopic approach achieving a subtotal tumor removal. Read More

    Neuroendocrine Dysfunction in a Young Athlete With Concussion: A Case Report.
    Clin J Sport Med 2017 Jan 20. Epub 2017 Jan 20.
    *Division of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada; and †Division of Endocrinology, Department of Internal Medicine, University of Calgary, Calgary, AB, Canada.
    An 18-year-old female ringette and basketball player presented to our sport concussion clinic 27 months after concussion with fatigue, headache, exercise intolerance, polyuria, nocturia, and difficulties concentrating. Her history was remarkable for 4 previous concussions. Her neurologic examination was normal. Read More

    Roflumilast and aquaporin-2 regulation in rat renal inner medullary collecting duct.
    Physiol Rep 2017 Jan;5(2)
    Epithelial Systems Biology Laboratory, Systems Biology Center NHLBI National Institutes of Health, Bethesda, Maryland, 20892-1603.
    Roflumilast is a cyclic nucleotide phosphodiesterase inhibitor that is FDA-approved for treatment of chronic obstructive pulmonary disease. With a view toward possible use for treatment of patients with X-linked nephrogenic diabetes insipidus (NDI) due to hemizygous mutations in the V2 vasopressin receptor, this study sought to determine the effect of roflumilast on aquaporin-2 (AQP2) phosphorylation, AQP2 trafficking, and water permeability in the rat inner medullary collecting duct (IMCD). In the presence of the vasopressin analog dDAVP (0. Read More

    Endoscopic versus microscopic transsphenoidal surgery in the treatment of pituitary adenoma: a systematic review and meta-analysis.
    World Neurosurg 2017 Jan 16. Epub 2017 Jan 16.
    Department of Neurosurgery, Weifang people's hospital, Shandong 261000, China.
    Background: Inconsistent findings have been reported regarding the efficacy and safety of endoscopic and microscopic transsphenoidal surgery for pituitary adenoma. This study aimed to assess the benefits and shortcomings of these surgical methods in patients with pituitary adenoma.

    Methods: The electronic databases PubMed, EmBase, and the Cochrane Library were systematically searched, as well as proceedings of major meetings. Read More

    A novel SLC12A1 gene mutation associated with hyperparathyroidism, hypercalcemia, nephrogenic diabetes insipidus, and nephrocalcinosis in four patients.
    Bone 2017 Jan 14;97:121-125. Epub 2017 Jan 14.
    Center for Endocrinology, Diabetes and Metabolism, Division of Endocrinology, Children's Hospital Los Angeles, Los Angeles, CA, United States; Keck School of Medicine of University of Southern California, Los Angeles, CA, United States. Electronic address:
    Solute Carrier Family 12 member 1 (SLC12A1) gene encodes the sodium-potassium-chloride co-transporter (NKCC2) at the apical membrane of the thick ascending loop of Henle (TAL). Bartter's syndrome (BS) type I is a rare, autosomal recessive, renal tubular disorder associated with mutation of the SLC12A1 gene. Presenting features include: hypokalemic metabolic alkalosis, hypercalciuria and nephrocalcinosis. Read More

    [Child Langerhans cell histiocytosis].
    Presse Med 2017 Jan 10;46(1):85-95. Epub 2017 Jan 10.
    Hôpital Trousseau, centre de référence des histiocytoses, service d'hémato-oncologie pédiatrique, 26, avenue du Dr-Netter, 75012 Paris, France.
    Definition: Langerhans cell histiocytosis (LCH) is defined by the association of a clinical and radiological involvement and a biopsy of a pathological tissue. Extension: it can affect any organ or system of the body but most commonly the bone (80% of cases), the skin (33%) and the pituitary (25%). Other organs are concerned such as liver, spleen, hematopoietic system and the lungs (15% each), lymph nodes (5-10%) and central nervous system (CNS) excluding the pituitary (2-4%). Read More

    IgG4-Related Hypophysitis: Case Report and Literature Review.
    Cureus 2016 Dec 1;8(12):e907. Epub 2016 Dec 1.
    Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico.
    IgG4-related hypophysitis is a rare, inflammatory process of the pituitary that mimics more commonly seen pituitary tumors. We report a case of IgG4-related hypophysitis in a 16-year-old female with diabetes insipidus who was found to have IgG4-related hypophysitis based on tissue diagnosis. This entity has not been previously described in a pediatric patient. Read More

    Transcranial approach in giant pituitary adenomas: results and outcome in a modern series.
    J Neurosurg Sci 2017 Jan 12. Epub 2017 Jan 12.
    Neurosurgery Department La Timone Hospital, Marseilles, France.
    Background: Today, transcranial (TC) approach indications are particularly rare in pituitary adenomas (PA), representing 1.1% of all PA surgeries in our experience. In these rare and selected cases, the complications, advantages, and disadvantages of TC approach were also analyzed. Read More

    Adipsic diabetes insipidus in adult patients.
    Pituitary 2017 Jan 10. Epub 2017 Jan 10.
    Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Beaumont Road, Dublin 9, Co., Dublin, Ireland.
    Introduction: Adipsic diabetes insipidus (ADI) is a very rare disorder, characterized by hypotonic polyuria due to arginine vasopressin (AVP) deficiency and failure to generate the sensation of thirst in response to hypernatraemia. As the sensation of thirst is the key homeostatic mechanism that prevents hypernatraemic dehydration in patients with untreated diabetes insipidus (DI), adipsia leads to failure to respond to aquaresis with appropriate fluid intake. This predisposes to the development of significant hypernatraemia, which is the typical biochemical manifestation of adipsic DI. Read More

    The neuroendocrine sequelae of paediatric craniopharyngioma: a 40-year meta-data analysis of 185 cases from three UK centres.
    Eur J Endocrinol 2017 Mar 10;176(3):359-369. Epub 2017 Jan 10.
    Royal Manchester Children's HospitalManchester, UK.
    Objectives: The management of paediatric craniopharyngiomas was traditionally complete resection (CR), with better reported tumour control compared to that by partial resection (PR) or limited surgery (LS). The subsequent shift towards hypothalamic sparing, conservative surgery with adjuvant radiotherapy (RT) to any residual tumour aimed at reducing neuroendocrine morbidity, has not been systematically studied. Hence, we reviewed the sequelae of differing management strategies in paediatric craniopharyngioma across three UK tertiary centres over four decades. Read More

    Hypofractionated stereotactic radiosurgery for pituitary metastases.
    J Neurooncol 2017 Jan 9. Epub 2017 Jan 9.
    Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    Pituitary metastases (PMs) are uncommon, representing only 1% of pituitary lesions. The diagnosis of PMs can be challenging and an optimal management remains to be determined. Here, we present a pilot clinical study on the efficacy and safety of hypofractionated stereotactic radiosurgery (SRS) with an optimized dosimetric plan in treating PMs. Read More

    Norman M. Dott, master of hypothalamic craniopharyngioma surgery: the decisive mentoring of Harvey Cushing and Percival Bailey at Peter Bent Brigham Hospital.
    J Neurosurg 2017 Jan 6:1-14. Epub 2017 Jan 6.
    Department of Neurosurgery, La Princesa University Hospital, Madrid, Spain.
    Norman McOmish Dott (1897-1973) developed surgical neurology in Edinburgh, Scotland, and was a scholar of worldwide renown. One of Dott's most notable contributions to neurosurgery was his understanding of hypothalamic physiology, mostly acquired through the comprehensive study of patients with lesions involving this region of the diencephalon, particularly craniopharyngiomas (CPs). Recognition of symptoms caused by hypothalamic disturbances allowed him to predict the accurate anatomical relationships between CPs and the hypothalamus, despite the rudimentary radiological methods available during the 1930s. Read More

    Significant improvement in chronic persistent headaches caused by small Rathke cleft cysts after transsphenoidal surgery.
    World Neurosurg 2017 Jan 2. Epub 2017 Jan 2.
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan, Address: 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
    Purpose: Rathke cleft cysts (RCC) are usually asymptomatic and can be observed using conservative methods. However, some patients with RCCs have severe headaches even if they are small enough to be confined to the sella, and these small RCCs have seldom been discussed. This study presents an investigation into clinical characteristics of small RCCs associated with severe headaches, demonstrating efficacy and safety of endoscopic transsphenoidal surgery (ETSS) to relieve headaches. Read More

    Liver X Receptor β (LXRβ) Increases AQP2 Protein Level via a Post-transcriptional Mechanism in Renal Collecting Ducts.
    Am J Physiol Renal Physiol 2017 Jan 4:ajprenal.00564.2016. Epub 2017 Jan 4.
    Dalian Medical University
    Liver X Receptors (LXRs) including LXRα and LXRβ are nuclear receptor transcription factors and play an important role in lipid and glucose metabolism. It has been previously reported that mice lacking LXRβ but not LXRα develop a severe urine concentrating defect, likely via a central mechanism. Here we provide evidence that LXRβ regulates water homeostasis through increasing aquaporin 2 (AQP2) protein levels in renal collecting ducts. Read More

    Erdheim-Chester disease and radiobiphosphonates bone scan: from a simple peripheral form to a rare axial location: A case report.
    Tunis Med 2016 Jun;94(6):167-171
    The Erdheim-Chester disease is a rare form of non Langherans histiocytosis. It can be expressed by a multi systemic disease interesting: bone, lung, heart, brain, retro peritoneum, skin and retro-orbital tissue. The diagnosis is established under the radiological aspect, bone scan uptake and immunohistological profile. Read More

    Overlap of Post-obstructive Diuresis and Unmasked Diabetes Insipidus in a Case of IgG4-related Retroperitoneal Fibrosis and Tuberoinfundibular Hypophysitis: A Case Report and Review of the Literature.
    Intern Med 2017;56(1):47-53. Epub 2017 Jan 1.
    Department of Nephrology, Hypertension, Diabetology, Crinology and Metabolism, Fukushima Medical University School of Medicine, Japan.
    The clinical picture of IgG4-related disease (IgG4-RD) is diverse because various organs can be affected. We describe the case of a 56-year-old man with acute renal failure and tuberoinfundibular hypophysitis due to IgG4-RD. Steroid therapy lowered the serum IgG4 level and ameliorated renal dysfunction, bilateral hydronephrosis and retroperitoneal fibrosis. Read More

    Pituitary Metastasis from Renal Cell Carcinoma: Description of a Case Report.
    Am J Case Rep 2017 Jan 3;18:7-11. Epub 2017 Jan 3.
    Division of Medical Oncology, Regional Hospital Center (CHR) Metz-Thionville, Ars-Laquenexy, France.
    BACKGROUND Pituitary metastasis is uncommon, breast and lung cancers being the most frequent primary tumors. Renal cell carcinoma (RCC) is a rare cause of pituitary metastases, with only a few cases described to date. CASE REPORT We report a case of a 61-year-old man who presented with a progressive deterioration of visual acuity and field associated with a bitemporal hemianopsia. Read More

    Mikulicz's Disease with hypophysitis - a new IgG4-mediated disorder.
    Endokrynol Pol 2016 ;67(6):622-626
    Department of Endocrinology, B.Y.L Nair Charitable Hospital & Topiwala National Medical College, Mumbai-400008, India.
    Introduction: We present a case of Mikulicz's Disease with hypophysitis. This is a rare clinical association as part of the group of IgG4- related diseases, a group of disorders which can have multiorgan involvement.

    Methods: A 55-year-old male patient was diagnosed with Mikulicz's disease. Read More

    Infundibulo-hypophysitis-like radiological image in a patient with pituitary infiltration of a diffuse large B-cell non-Hodgkin lymphoma.
    Endocrinol Diabetes Metab Case Rep 2016 17;2016. Epub 2016 Dec 17.
    Department of Endocrinology and Metabolism , Neuroendocrinology Clinic, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan , Mexico.
    : Non-Hodgkin lymphoma (NHL) is a hematological tumor caused by abnormal lymphoid proliferation. NHL can arise in any part of the body, including central nervous system (CNS). However, pituitary involvement is a quite rare presentation. Read More

    Transsphenoidal posterior pituitary lobe biopsy in patients with neurohypophysial lesions.
    World Neurosurg 2016 Dec 27. Epub 2016 Dec 27.
    Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
    Objective: The differential diagnosis of neurohypophysial lesions is difficult and surgical biopsies are indispensable in the histological diagnosis of some patients. Although pituitary stalk biopsies are uniformly performed, there is a considerable risk that they will result in impaired hormonal secretion. We attempt to clarify the usefulness and safety of posterior pituitary lobe biopsy by transsphenoidal surgery (TSS). Read More

    Transoral robotic surgery for sellar tumors: first clinical study.
    J Neurosurg 2016 Dec 23:1-8. Epub 2016 Dec 23.
    Department of Neurosurgery and.
    OBJECTIVE The aim of this study was to confirm the feasibility of an innovative transoral robotic surgery (TORS), using the da Vinci Surgical System, for patients with sellar tumors. This technique was designed to offer a new minimally invasive approach, without soft-palate splitting, that avoids the rhinological side effects of classic endonasal approaches. METHODS The authors performed a prospective study of TORS in patients with symptomatic sellar tumors. Read More

    Lower airway disease and pituitary surgery: Is there an association with postoperative cerebrospinal fluid leak?
    Laryngoscope 2016 Dec 23. Epub 2016 Dec 23.
    Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan, U.S.A.
    Objectives/hypothesis: To explore the relationship between lower airway disease and postoperative cerebrospinal fluid (CSF) rhinorrhea among patients undergoing pituitary surgery STUDY DESIGN: Retrospective review.

    Methods: A retrospective review of the Healthcare Cost and Utilization Project's 2013 National Inpatient Sample was conducted to characterize the hospital stay and surgical outcomes of patients undergoing pituitary surgery. Patients with lower airway disease (including chronic obstructive pulmonary disease and asthma) were compared to a disease-free population identifying demographics and complications over-represented in the lower airway group. Read More

    Central diabetes insipidus.
    Nagoya J Med Sci 2016 Dec;78(4):349-358
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous study suggests that infundibulo-neurohypophysitis might be an underlying cause of idiopathic CDI. Read More

    Safety of transsphenoidal microsurgical approach in patients with an ACTH-secreting pituitary adenoma.
    Endocrine 2016 Dec 22. Epub 2016 Dec 22.
    Pituitary Unit of the Department of Neurosurgery, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.
    Purpose: Patients affected by Cushing's disease often have important comorbidities directly linked to hypercortisolism that might enhance the operative risk. We report the safety of transsphenoidal surgery in patients affected by Cushing's disease as compared with patients with nonfunctioning pituitary adenoma.

    Methods: We have retrospectively analyzed 142 patients with Cushing's disease and 299 patients with nonfunctioning pituitary adenoma who underwent transsphenoidal surgery performed by a single experienced neurosurgeon between September 2007 and December 2014. Read More

    Suprasellar Epidermoid Cyst with Atypical Imaging Findings.
    World Neurosurg 2017 Feb 18;98:870.e1-870.e3. Epub 2016 Dec 18.
    Department of Pathology, Melaka Manipal Medical College, Manipal, India.
    A 65-year-old female presented with progressive unilateral vision loss leading to blindness and features of central diabetes insipidus (DI) for 3 months' duration. Imaging showed a well-circumscribed, lobulated, rim-enhancing suprasellar lesion with inhomogeneous diffusion restriction. Through a pterional trans-sylvian approach, subtotal resection was performed and histopathology revealed features of an epidermoid cyst. Read More

    Clinicoradiological features and surgical outcomes of sellar xanthogranulomas: a single center 10-year experience.
    World Neurosurg 2016 Dec 16. Epub 2016 Dec 16.
    Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6, Tiantan Xili, Dongcheng District, Beijing 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing 100050, China. Electronic address:
    Background: Xanthogranulomas are uncommon granulomatous entities, and those occurring in the sellar region are extremely rare, with a limited number of cases reported in the literature. The diagnosis, management, and prognosis of sellar xanthogranulomas remain poorly understood.

    Methods: We retrospectively reviewed the profiles of 14 patients with histologically proven sellar xanthogranulomas in our institution between Jan 2006 and July 2016. Read More

    Hydrochlorothiazide in intensive care unit-acquired hypernatremia: A randomized controlled trial.
    J Crit Care 2016 Dec 2;38:225-230. Epub 2016 Dec 2.
    Department of Intensive Care, Medical Centre Leeuwarden, PO Box 888, 8901 BK Leeuwarden, the Netherlands. Electronic address:
    Purpose: Thiazides are suggested as a treatment for intensive care unit (ICU)-acquired hypernatremia (IAH). The primary aim of the study was reducing serum sodium concentration (sNa) in patients with IAH with hydrochlorothiazide (HCT) in comparison to placebo. Secondary end points were a difference in urine sodium concentration (uNa) and duration of severe IAH. Read More

    A case of central diabetes insipidus associated with cardiac dysfunction.
    Clin Case Rep 2016 Dec 11;4(12):1101-1106. Epub 2016 Oct 11.
    Department of Internal MedicineOjiya General HospitalNiigataJapan; Center of Diabetes, Endocrinology and MetabolismJoetsu General HospitalNiigataJapan.
    Central diabetes insipidus (CDI) results from a deficiency of arginine vasopressin (AVP) secretion. It is treated by replacement therapy with the synthetic AVP analogue desmopressin. To prevent heart failure in patients with CDI accompanied by cardiac dysfunction, controlling sodium and water intake is essential, using the minimum effective dose of desmopressin. Read More

    1 OF 199