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    Treatment regimens by pediatric nephrologists in children with congenital nephrogenic diabetes insipidus: A MWPNC study
    Clin Nephrol 2017 Nov 22. Epub 2017 Nov 22.
    Background: Congenital nephrogenic diabetes insipidus (NDI) is a rare genetic disorder affecting urinary concentration. Clinicians have varied medication regimens as well as nutritional plan approaches for these children.

    Materials And Methods: An electronic survey was distributed to member pediatric nephrologists of the Midwest Pediatric Nephrology Consortium via email (n = 179). Read More

    Small cell glioblastoma of the sella turcica region: a case report and review of the literature.
    World Neurosurg 2017 Nov 15. Epub 2017 Nov 15.
    Department of Neurosurgery, First Hospital of Jilin University, Changchun, China, 130021. Electronic address:
    Background: Glioblastomas in the sellar region are very rare; in most cases, the tumor originates from the optic nerve/optic chiasm. Only 4 cases of sellar glioblastoma with a non-optic origin have been reported. We present such a case with detailed clinical, imaging and histopathological information. Read More

    A novel role for renal epithelial cells and the medullary sodium gradient in the local immune response.
    Kidney Int 2017 Dec;92(6):1308-1311
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA. Electronic address:
    The extreme hypertonicity of the renal medulla plays a central role in regulating volume status. A recent publication in Cell has identified a novel role for the high sodium environment and the local epithelial cells in the recruitment of mononuclear phagocytes, potentially contributing to the defense against ascending urinary tract infection. Read More

    Letter to the editor: Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis.
    Eur J Endocrinol 2017 Nov 15. Epub 2017 Nov 15.
    L De Marinis, Catholic University of the Sacred Heart, Gemelli Foundation, Rome, Pituitary Unit, Institute of Endocrinology, Rome, Italy
    As primary autoimmune hypophysitis represents a rare disease and, recently, two monocentric Italian series of affected patients have been described,with several similarities, we think that discussing the similarities and the differences of these two series would contribute in improving knowledge on this very rare disease. Read More

    Joint approach based on clinical and imaging features to distinguish non-neoplastic from neoplastic pituitary stalk lesions.
    PLoS One 2017 15;12(11):e0187989. Epub 2017 Nov 15.
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
    Purpose: Distinguishing non-neoplastic pituitary stalk lesions (non-NPSLs) from neoplastic pituitary stalk lesions (NPSLs) is a major concern in guiding treatment for a thickened pituitary stalk. Our study aimed to aid provide preoperative diagnostic assistance by combining clinical and magnetic resonance imaging (MRI) findings to distinguish non-NPSLs from NPSLs.

    Materials And Methods: We recruited 158 patients with thickened pituitary stalk lesions visible on MRI. Read More

    The soluble (Pro) renin receptor does not influence lithium-induced diabetes insipidus but does provoke beiging of white adipose tissue in mice.
    Physiol Rep 2017 Nov;5(21)
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah.
    Earlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy develop polyuria associated NDI that might be secondary to downregulation of renal AQP2. We hypothesized that sPRR-His attenuates indices of NDI associated with lithium treatment. Read More

    Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment. An Update.
    Int J Mol Sci 2017 Nov 10;18(11). Epub 2017 Nov 10.
    Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70126 Bari, Italy.
    Under physiological conditions, excessive loss of water through the urine is prevented by the release of the antidiuretic hormone arginine-vasopressin (AVP) from the posterior pituitary. In the kidney, AVP elicits a number of cellular responses, which converge on increasing the osmotic reabsorption of water in the collecting duct. One of the key events triggered by the binding of AVP to its type-2 receptor (AVPR2) is the exocytosis of the water channel aquaporin 2 (AQP2) at the apical membrane the principal cells of the collecting duct. Read More

    Suprasellar and recurrent pediatric craniopharyngiomas: expanding indications for the extended endoscopic transsphenoidal approach.
    J Neurosurg Pediatr 2017 Nov 10:1-9. Epub 2017 Nov 10.
    Departments of 1 Neurosurgery.
    OBJECTIVE The expanded endonasal endoscopic transsphenoidal approach has become increasingly used for craniopharyngioma surgery in the pediatric population, but questions still persist regarding its utility in younger children, in recurrent and irradiated tumors, and in masses primarily located in the suprasellar region. The narrow corridor, incomplete pneumatization, and fear of hypothalamic injury have traditionally relegated this approach to application in older children with mostly cystic craniopharyngiomas centered in the sella. The authors present a series of consecutive pediatric patients in whom the endonasal endoscopic approach was used to remove craniopharyngiomas from patients of varied ages, regardless of the location of the tumor and previous treatments or surgeries, to ascertain if the traditional concerns about limitations of this approach are worth reevaluating METHODS Eleven consecutive pediatric patients (age ≤ 18 years) underwent surgery via an endoscopic transsphenoidal approach at NewYork-Presbyterian/Weill Cornell Medical Center from 2007 to 2016. Read More

    Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy.
    Swiss Med Wkly 2017 Nov 9;147:w14514. Epub 2017 Nov 9.
    Endocrinology, Diabetology and Metabolism, University Hospital Basel, Switzerland / Department of Clinical Research, University Hospital Basel, Switzerland.
    Primary polydipsia (PP) has been defined as excessive intake of fluids. However, the pathogenesis of PP remains unexplored. Different theories include a dysfunction in the thirst mechanism, involvement of the hippocampus, stress-reducing behaviour and lesion occurrences in specific areas of the brain. Read More

    Functional characterization of AVPR2 mutants found in Turkish patients with nephrogenic diabetes insipidus.
    Endocr Connect 2017 Nov 8. Epub 2017 Nov 8.
    H Mergen, Department of Biology, Hacettepe University, Faculty of Science, Ankara, Turkey.
    Diabetes insipidus is a rare disorder characterized by an impairment in water balance because of the inability to concentrate urine. While central Diabetes insipidus is caused by mutations in the AVP, the reason for genetically determined nephrogenic Diabetes insipidus can be mutations in AQP2 or AVPR2. After release of AVP from posterior pituitary into blood stream it binds to AVPR2 which is one of the receptors for AVP and is mainly expressed in principal cells of collecting ducts of kidney. Read More

    Acta Clin Croat 2016 12;55(4):650-4
    The aim is to present unusual clinical course and magnetic resonance imaging (MRI) features of pituitary abscess. A 59-year-old man presented with fever, polyuria, polydipsia and marked weight loss within the last two months. Basic endocrinology tests revealed the presence of anterior pituitary dysfunction, associated with central diabetes insipidus and increased levels of inflammatory markers. Read More

    Acute-Onset Panhypopituitarism Nearly Missed by Initial Cosyntropin Testing.
    Case Rep Crit Care 2017 3;2017:7931438. Epub 2017 Oct 3.
    Medical University Clinic, Kantonsspital Aarau, Aarau, Switzerland.
    Introduction: Diagnosis of adrenal crisis and panhypopituitarism in patients with septic shock is difficult but crucial for outcome.

    Case: A 66-year-old woman with metastasized breast cancer presented to the ED with respiratory insufficiency and septic shock after a 2-day history of the flu. After transfer to the ICU, corticosteroids were started in addition to antibiotics, as the patient was vasopressor-nonresponsive. Read More

    Progression from isolated growth hormone deficiency to combined pituitary hormone deficiency.
    Growth Horm IGF Res 2017 Oct 19;37:19-25. Epub 2017 Oct 19.
    Developmental Endocrinology Research Group, UCL Institute of Child Health and Department of Endocrinology, Great Ormond Street Hospital for Children, WC1N 1EH, London, UK. Electronic address:
    Growth hormone deficiency (GHD) can present at any time of life from the neonatal period to adulthood, as a result of congenital or acquired insults. It can present as an isolated problem (IGHD) or in combination with other pituitary hormone deficiencies (CPHD). Pituitary deficits can evolve at any time from GHD diagnosis. Read More

    N-terminal pro-B-type Natriuretic Peptide in three different mechanisms of dysnatremia onset after a child's craniopharyngioma surgery.
    • Authors:
    Neuro Endocrinol Lett 2017 Oct 6;38(5):321-324. Epub 2017 Oct 6.
    Craniopharyngioma, due to its sellar location, can be perioperatively complicated by different types of dysnatremia. We present a rare postoperative onset of a combination of three different mechanisms of dysnatremia with N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) and renal function parameters in a boy with a good outcome after craniopharyngioma surgery: 1/ Central diabetes insipidus (CDI) onset immediately after the operation, hypernatremia with peak serum sodium (SNa) 158 mmol/l) caused by free water polyuria (electrolyte-free water clearance, EWC 0.104 ml/s), NT-proBNP 350 pg/ml; 2/ cerebral salt wasting (CSW) onset on day 7, hyponatremia (SNa 128 mmol/l) with hypoosmolality (measured serum osmolality, SOsm 265 mmol/kg) caused by natriuresis (sodium - daily output 605 mmol/day, fractional excretion 0. Read More

    The Hypothalamic-Pituitary Axis and Autoantibody Related Disorders.
    Int J Mol Sci 2017 Nov 3;18(11). Epub 2017 Nov 3.
    Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Cagliari, Italy.
    This review summarized different studies reporting the presence of autoantibodies reacting against cells of the pituitary (APAs) and/or hypothalamus (AHAs). Both APAs and AHAs have been revealed through immunofluorescence using different kinds of substrates. Autoantibodies against gonadotropic cells were mainly found in patients affected by cryptorchidism and hypogonadotropic hypogonadism while those against prolactin cells were found in different kinds of patients, the majority without pituitary abnormalities. Read More

    Prednisolone-responsive Postpartum IgG4-related Hypophysitis.
    Intern Med 2017 Nov 1. Epub 2017 Nov 1.
    Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Japan.
    We herein report the case of a 25-year-old woman who presented with severe headache and visual field defects after childbirth. Magnetic resonance imaging revealed marked swelling of the pituitary gland, and an endocrinological examination revealed panhypopituitarism and diabetes insipidus. An immunohistological analysis of a transsphenoidal biopsy sample of the pituitary gland showed the significant accumulation of an immunogloblin G4 (IgG4)-positive population, leading to the diagnosis of IgG4-related hypophysitis. Read More

    Morbidity and mortality associated with hypernatremia in patients with severe traumatic brain injury.
    Neurosurg Focus 2017 Nov;43(5):E2
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.
    OBJECTIVE Hypernatremia is independently associated with increased mortality in critically ill patients. Few studies have evaluated the impact of hypernatremia on early mortality in patients with severe traumatic brain injury (TBI) treated in a neurocritical care unit. METHODS A retrospective review of patients with severe TBI (admission Glasgow Coma Scale score ≤ 8) treated in a single neurocritical care unit between 1986 and 2012 was performed. Read More

    Cardiovascular autonomic dysfunction in patients with idiopathic diabetes insipidus.
    Pituitary 2017 Oct 28. Epub 2017 Oct 28.
    Coagulation Section, Department of Cardiovascular and Thoracic Sciences, University of Padova, Padova, Italy.
    Introduction: Central diabetes insipidus (DI) is a rare disease characterized by the excretion of excessive volumes of dilute urine due to reduced levels of the antidiuretic hormone arginine vasopressin (AVP), caused by an acquired or genetic defect in the neurohypophysis. The aim of this study was to identify any autonomic dysfunction (AD) in patients with DI as a possible cofactor responsible for their reportedly higher mortality.

    Methods: The study involved 12 patients (6 females) with central idiopathic DI and a well-controlled electrolyte balance, and 12 controls matched for age, sex and cardiovascular risk factors, who were assessed using the tilt, lying-to-standing, hand grip, deep breath, Valsalva maneuver and Stroop tests. Read More

    Previously unreported abnormalities in Wolfram Syndrome Type 2.
    Pediatr Endocrinol Diabetes Metab 2017 ;23(2):107-110
    Ph.D. candidate. Department of Molecular Biology. Centre INRS-Institut Armand-Frappier, Laval, Quebec, Canada.
    Wolfram syndrome (WFS) is a rare autosomal recessive disease with non-autoimmune childhood onset insulin dependent diabetes and optic atrophy. WFS type 2 (WFS2) differs from WFS type 1 (WFS1) with upper intestinal ulcers, bleeding tendency and the lack ofdiabetes insipidus. Li-fespan is short due to related comorbidities. Read More

    Assay of Desmopressin Acetate in Nasal Spray: Development of Validated Pre Column HPLC-Fluorescence Method.
    Adv Pharm Bull 2017 Sep 25;7(3):451-459. Epub 2017 Sep 25.
    Department of Pharmaceutical chemistry, SNJB's SSDJ College of Pharmacy, Chandwad (Maharashtra)-423 101, India.
    Purpose: Desmopressin acetate (DDAPV), a synthetic analogue of vasopressin, has been recommended to be used in diabetes insipidus, mild forms of hemophilia and Von Willebrand disease. The DDAPV is available for adminstration via different routes viz. oral, parenteral and nasal, however its dose is very less in case of nasal sprays (20 µg) and parenteral route (4 µg) compared to oral route (0. Read More

    Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
    Am J Physiol Renal Physiol 2017 Oct 25:ajprenal.00297.2017. Epub 2017 Oct 25.
    Radboud University Nijmegen Medical Centre
    Lithium, given to bipolar disorder patients, causes nephrogenic diabetes insipidus (Li-NDI), a urinary concentrating defect. Li-NDI is due to downregulation of principal cell AQP2 expression, which coincides with principal cell proliferation. The metabolic effect of lithium on principal cells, however, is unknown and investigated here. Read More

    Microsurgical therapy of pituitary adenomas.
    Endocrine 2017 Oct 24. Epub 2017 Oct 24.
    Department of Neurosurgery and Gamma Knife Radiosurgery, San Raffaele University Health Institute, Milan, Italy.
    Purpose: We report the efficacy and safety of transsphenoidal microsurgery in a large and homogeneous cohort of patients with pituitary adenomas (PAs) treated at a single Institute by a single neurosurgeon.

    Methods: A total of 2145 consecutive patients undergoing first surgery for a PA were included: 795 (37.1%) had a nonfunctioning pituitary adenoma (NFPA), 595 (27. Read More

    [Difficult diagnosis of Erdheim Chester disease revealed by central diabetes insipidus].
    Rev Med Liege 2017 Oct;72(10):436-438
    Service d'Endocrinologie-Diabétologie et Médecine interne, CHU Tahar Sfar, Mahdia, Tunisie.
    The Erdheim Chester disease is a rare form of non Langerhans cell histiocytosis. Its rarity and its unspecific clinical presentation, make that its diagnosis is often delayed. We report the case of a 50 years old female who has an Erdheim Chester disease, revealed by a central diabetes insipidus with thickening of the pituitary stalk, with associated gonadotropin deficiency. Read More

    Perianal Langerhans cell histiocytosis: a rare presentation in an adult male.
    Autops Case Rep 2017 Jul-Sep;7(3):38-43. Epub 2017 Sep 30.
    Menoufia University, Liver Institute. Shebein Elkom, Menoufia, Egypt.
    Langerhans cell histiocytosis (LCH) is a rare disease characterized by a proliferation of cells that show immunophenotypic and ultrastructural similarities with antigen-presenting Langerhans cells of mucosal sites and skin. LCH in adults is rare, and there are still many undiagnosed/misdiagnosed patients. We describe LCH involvement of the perianal region of a 33-year-old male with a previous history of diabetes insipidus. Read More

    Central Diabetes Insipidus Linked to Rathke's Cleft Cyst, Polyuria in a 17-year-old Girl.
    Electrolyte Blood Press 2017 Sep 30;15(1):23-25. Epub 2017 Sep 30.
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
    A 17-year-old girl presented with polyuria (7 L/day) and polydipsia for one year. Initial urine osmolality was 113mOsm/kg H2O. Following 6 h of fluid restriction, serum plasma osmolality reached 300mOsm/kg H2O, whereas urine osmolality was 108mOsm/kg H2O. Read More

    The supraorbital eyebrow approach for removal of craniopharyngioma in children: a case series.
    Childs Nerv Syst 2017 Oct 16. Epub 2017 Oct 16.
    Division of Pediatric Neurosurgery of the Department of Surgery and Anatomy, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil.
    Objective: Craniopharyngiomas can be a surgical challenge for the pediatric neurosurgeon. Ideally, total removal must be achieved. However, the need to reduce surgical morbidity and preserve quality of life has led to a number of neurosurgical approaches in order to attain this goal. Read More

    A rare case of CD1a-negative Langerhans cell histiocytosis of the central nervous system in a child.
    Clin Case Rep 2017 Oct 1;5(10):1664-1667. Epub 2017 Sep 1.
    Cook Children's Medical CenterFort WorthTexas.
    Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [Blood, 126, 2015, 26 and N Engl J Med, 331, 1994, 154]. Read More

    Endoscopic Transsphenoidal Surgery Outcomes in 331 Nonfunctioning Pituitary Adenoma Cases After a Single Surgeon Learning Curve.
    World Neurosurg 2017 Oct 7. Epub 2017 Oct 7.
    Pituitary Center, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
    Objective: The outcomes of recent endoscopic surgery of nonfunctioning pituitary adenomas (NFPAs) are controversial when compared with traditional microscopic surgery. We aimed to assess the outcomes of endoscopic transsphenoidal surgeries performed by 1 surgeon with 7 years of experience and elucidate the predictive factors for surgical outcomes for NFPAs.

    Methods: We included 331 patients (155 men and 176 women) with clinical NFPAs who underwent transsphenoidal surgery because of visual symptoms by a single surgeon in Seoul National University Hospital from March 2010 to May 2016. Read More

    Endoscopic Endonasal Transsphenoidal Approach to Pituitary Adenoma: A Multi-disciplinary Approach.
    J Nepal Health Res Counc 2017 Sep 8;15(2):174-177. Epub 2017 Sep 8.
    Department of Neurological Surgery, Kathmandu Medical College, Sinamangal  Kathmandu, Nepal.
    Background: The excellent visualization and minimally invasive approach employed in endoscopic endonasal procedures has now revolutionized the pituitary surgery, replacing the transnasal microscopic technique worldwide. However, it involves major shift in hand-eye co-ordination from static 3 dimensional images of microscope to 2 dimensional endoscopic images hence demands training and inter-disciplinary approach. Here we present our experiences in learning and developing a safe endonasal transsphenoidal endoscopic approach to resect pituitary adenomas. Read More

    Binostril endoscopic transsphenoidal neurosurgery for pituitary adenomas: experience with 42 patients.
    Oncotarget 2017 Sep 9;8(40):69020-69024. Epub 2017 Apr 9.
    Department of Neurosurgery, The First People's Hospital of Yancheng, Yancheng, P R China.
    Here we review the technical aspects of our experience with the neuroendoscopic bilateral nostril (binostril) transsphenoidal approach for pituitary adenomas. A total of 42 patients were treated in our hospital from September 2013 to December 2015. Total tumor resection was completed in 31 cases, nearly full resection was achieved in 9 cases, and partial resection was achieved in 2 cases. Read More

    Acute effects of low-level laser therapy (660 nm) on oxidative stress levels in diabetic rats with skin wounds.
    J Exp Ther Oncol 2017 Sep;11(2):85-89
    University Nove de Julho (UNINOVE), Postgraduate Program in Rehabilitation Sciences and Postgraduate Program in Biophotonics, São Paulo/SP, Brazil.
    Background: Laser therapy influences oxidative stress parameters such as the activity of antioxidant enzymes and the production of reactive oxygen species.

    Objective: To analyze the effects of low-level laser therapy on oxidative stress in diabetics rats with skin wounds.

    Methods: Thirty-six animals were divided into 4 groups: NDNI: non-diabetic rats with cutaneous wounds that not received laser therapy; NDI: non-diabetic rats with cutaneous wounds that received laser therapy; DNI: diabetic rats with skin wounds who did not undergo laser therapy; DI: rats with diabetes insipidus and cutaneous wounds and received laser therapy. Read More

    The Polyuria-Polydipsia Syndrome: a diagnostic challenge.
    Intern Med J 2017 Oct 2. Epub 2017 Oct 2.
    Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Australia.
    The main determinants for the maintenance of water homeostasis are the hormone arginine-vasopressin (AVP) and thirst. Disturbances in these regulatory mechanisms can lead to the polyuria-polydipsia syndrome, which comprises of three different conditions: central diabetes insipidus (DI) due to insufficient secretion of AVP, nephrogenic DI caused by renal insensitivity to AVP action, and primary polydipsia due to excessive fluid intake and consequent physiologic suppression of AVP. It is crucial to determine the exact diagnosis because treatment strategies vary substantially. Read More

    Endoscopic endonasal approach for craniopharyngioma: the importance of the relationship between pituitary stalk and tumor.
    J Neurosurg 2017 Sep 29:1-9. Epub 2017 Sep 29.
    Departments 1 Neurosurgery and.
    OBJECTIVE The endoscopic endonasal approach (EEA) is commonly used for the treatment of craniopharyngioma; therefore, it is essential to analyze outcomes in order to understand the benefits and drawbacks. The goal of this paper was to evaluate the clinical features and outcomes associated with this treatment approach. METHODS From July 2010 to March 2016, 82 adult craniopharyngioma patients underwent an EEA at the authors' institution. Read More

    Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.
    Pediatr Neurosurg 2017 Sep 26. Epub 2017 Sep 26.
    Department of Neurosurgery, Niigata University, Niigata, Japan.
    We present a pediatric case of a rapidly expanding third ventricle germ cell tumor (GCT). A 14-year-old boy suffered from gradual-onset central diabetes insipidus (DI) and received desmopressin treatment. Magnetic resonance imaging (MRI) showed nonspecific findings of the pituitary-hypothalamic axis. Read More

    Central Diabetes Insipidus in Refractory Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
    Intern Med 2017 Nov 25;56(21):2943-2948. Epub 2017 Sep 25.
    Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
    We herein describe two cases of refractory antineutrophil cytoplasmic antibody-associated vasculitis (AAV) complicated with diabetes insipidus (DI) possibly related to hypertrophic pachymeningitis (HP). One patient had microscopic polyangiitis and HP, which were refractory to cyclophosphamide, azathioprine, rituximab, mycophenolate mofetil (MMF), and mizoribine. Remission was finally achieved with the use of etanercept, but DI occurred 5 years later. Read More

    Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors.
    Handb Exp Pharmacol 2017 Sep 23. Epub 2017 Sep 23.
    Institut de Génomique Fonctionnelle, CNRS, INSERM, Université de Montpellier, 141 rue de la cardonille, 34094, Montpellier Cedex 05, France.
    Pharmacological chaperones recently opened new possibilities in G protein-coupled receptor drug discovery. Even more interestingly, some unique ligands combine pharmacological chaperoning and biased agonism properties, boosting their therapeutic interest in many human diseases resulting from G protein-coupled receptor mutation and misfolding. These compounds displaying dual characteristics would constitute a perfect treatment for congenital Nephrogenic Diabetes Insipidus, a typical conformational disease. Read More

    Guidelines for the management of a brain death donor in the rhesus macaque: A translational transplant model.
    PLoS One 2017 19;12(9):e0182552. Epub 2017 Sep 19.
    University of Wisconsin Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
    Introduction: The development of a translatable brain death animal model has significant potential to advance not only transplant research, but also the understanding of the pathophysiologic changes that occur in brain death and severe traumatic brain injury. The aim of this paper is to describe a rhesus macaque model of brain death designed to simulate the average time and medical management described in the human literature.

    Methods: Following approval by the Institutional Animal Care and Use Committee, a brain death model was developed. Read More

    ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis.
    J Clin Invest 2017 10 18;127(10):3897-3912. Epub 2017 Sep 18.
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
    Peptide hormones are crucial regulators of many aspects of human physiology. Mutations that alter these signaling peptides are associated with physiological imbalances that underlie diseases. However, the conformational maturation of peptide hormone precursors (prohormones) in the ER remains largely unexplored. Read More

    Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus.
    J Clin Invest 2017 Oct 18;127(10):3591-3593. Epub 2017 Sep 18.
    Department of Pharmacology and Physiology, University of Montreal, Montreal, Quebec, Canada.
    Deficiency of the antidiuretic hormone arginine vasopressin (AVP) underlies diabetes insipidus, which is characterized by the excretion of abnormally large volumes of dilute urine and persistent thirst. In this issue of the JCI, Shi et al. report that Sel1L-Hrd1 ER-associated degradation (ERAD) is responsible for the clearance of misfolded pro-arginine vasopressin (proAVP) in the ER. Read More

    Incidence of Diabetes Insipidus in Postoperative Period among the Patients Undergoing Pituitary Tumour Surgery.
    Mymensingh Med J 2017 Jul;26(3):642-649
    Dr Md Lylatul Kadir, OSD, DGHS, Mohakhali, Dhaka, Bangladesh; Student MS Thesis Part, Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh.
    Post operative complications after pituitary tumour surgery vary according to procedure. There are several surgical procedures being done such as transcranial, transsphenoidal microsurgical and transsphenoidal endoscopic approaches. One of the commonest complications is diabetes insipidus (DI). Read More

    Recovery from diabetes insipidus and preservation of thyroid function after craniopharyngioma removal and pituitary stalk sectioning.
    Clin Neurol Neurosurg 2017 Nov 9;162:36-40. Epub 2017 Sep 9.
    Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
    Objectives: Craniopharyngioma is a slow-growing tumor, but long-term tumor control with maintenance of quality of life is sometimes very difficult to achieve, and hypothalamic disturbance should be strictly avoided in the treatment. However, management of the pituitary gland and/or pituitary stalk varies among surgeons and institutions.

    Patients And Methods: This retrospective review identified 44 patients, 24 males and 20 females with craniopharyngiomas who were initially treated by surgery through the extended transsphenoidal approach with pituitary stalk sectioning at a single institute. Read More

    Preoperative risk factors for postoperative complications in endoscopic pituitary surgery: a systematic review.
    Pituitary 2017 Sep 15. Epub 2017 Sep 15.
    Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
    Background: The ability to preoperatively predict postoperative complication risks is valuable for individual counseling and (post)operative planning, e.g. to select low-risk patients eligible for short stay surgery or those with higher risks requiring special attention. Read More

    [The efficacy of desmopressin in the treatment of central diabetes insipidus after resection of chiasmo-sellar region tumors].
    Zh Vopr Neirokhir Im N N Burdenko 2017 ;81(4):61-69
    Burdenko Neurosurgical Institute, Moscow, Russia.
    Central diabetes insipidus (CDI) is a neuroendocrine disease, the pathogenesis of which is associated with abnormal secretion of the antidiuretic hormone. One of the specific causes of CDI is neurosurgical resection of chiasmatic-sellar region tumors.

    Aim: to study the efficacy and safety of desmopressin in CDI patients after resection of chiasmatic-sellar region (CSR) tumors. Read More

    Microsurgical versus endoscopic transsphenoidal resection for acromegaly: a systematic review of outcomes and complications.
    Acta Neurochir (Wien) 2017 Nov 14;159(11):2193-2207. Epub 2017 Sep 14.
    Department of Neurosurgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
    Purpose: The aim of this systematic review is to evaluate the long-term endocrine outcomes and postoperative complications following endoscopic vs. microscopic transsphenoidal resection (TSR) for the treatment of acromegaly.

    Methods: A literature review was performed, and studies with at least five patients who underwent TSR for acromegaly, reporting biochemical remission criteria and long-term remission outcomes were included. Read More

    Tacrolimus Aggravated Tube Feeding Syndrome with Acute Renal Failure in a Pediatric Liver Transplant Recipient.
    Case Rep Transplant 2017 20;2017:7345680. Epub 2017 Aug 20.
    KUNO University Children's Hospital, Regensburg, Germany.
    Acute renal failure can be caused by calcineurin inhibitors (CNIs), due to arteriolopathy and altered tubular function. Within this context, we present the case of a 14-month-old liver transplant recipient who suffered an acute polyuric renal failure during a short episode of hypercaloric feeding. In our case, CNI-induced distal RTA led to nephrocalcinosis and therefore to secondary nephrogenic diabetes insipidus. Read More

    Molecular clustering of patients with diabetes and pulmonary tuberculosis: A systematic review and meta-analysis.
    PLoS One 2017 13;12(9):e0184675. Epub 2017 Sep 13.
    Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
    Introduction: Many studies have explored the relationship between diabetes mellitus (DM) and tuberculosis (TB) demonstrating increased risk of TB among patients with DM and poor prognosis of patients suffering from the association of DM/TB. Owing to a paucity of studies addressing this question, it remains unclear whether patients with DM and TB are more likely than TB patients without DM to be grouped into molecular clusters defined according to the genotype of the infecting Mycobacterium tuberculosis bacillus. That is, whether there is convincing molecular epidemiological evidence for TB transmission among DM patients. Read More

    Diabetes insipidus after discontinuation of vasopressin infusion for septic shock.
    J Clin Pharm Ther 2017 Sep 11. Epub 2017 Sep 11.
    Division of Critical Care Medicine, Montefiore Medical Center, Bronx, NY, USA.
    What Is Known And Objective: Despite widespread use of vasopressin for the treatment of septic shock, few cases of diabetes insipidus (DI) following its discontinuation have been reported.

    Case Summary: A 54-year-old man presented with pneumonia progressing to septic shock, requiring norepinephrine and vasopressin for refractory hypotension. After clinical improvement, the patient on 3 separate occasions developed polyuria and severe hypernatremia upon discontinuation of vasopressin, with prompt recovery upon its resumption. Read More

    Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature.
    J Neurosurg 2017 Sep 1:1-13. Epub 2017 Sep 1.
    Department of Neurosurgery, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, New York.
    OBJECTIVE Surgery is generally the first-line therapy for acromegaly. For patients with residual or recurrent tumors, several treatment options exist, including repeat surgery, medical therapy, and radiation. Reoperation for recurrent acromegaly has been associated with poor results, with hormonal control usually achieved in fewer than 50% of cases. Read More

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