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    10010 results match your criteria Diabetes Insipidus

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    Ann Endocrinol (Paris) 2016 Oct;77 Suppl 1:S11-S18
    Fédération d'Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, 59 Boulevard Pinel, 69677 Bron, France; Université Lyon 1, 43 Boulevard du 11 novembre 1918, 69100 Villeurbanne, France.
    Diabetes insipidus is a syndrome that associates both hypotonic polyuria and polydipsia, due to insufficient or ineffective arginine vasopressin (AVP) synthesis, or to AVP resistance. The diagnosis between central/renal origin, or an abnormal thirst regulation (primary polydipsia) is required to organize an adapted management. Because water deprivation tests are not reliable, it's often based on medical history, response to treatment and MRI. Read More
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    Histiocytosis X: A seven-year experience at a children's hospital.
    J Am Acad Dermatol 1985 Sep 5;13(3):481-496. Epub 2008 Nov 5.
    From the Divisions of Dermatology and Hematology, Departments of Pediatrics and Pathology, Northwestern University Medical School, Chicago, IL.
    Thirty-two patients with histiocytosis X were evaluated and treated at Children's Memorial Hospital, Chicago, during the years 1978 to 1984. Twelve patients (38%) had solitary or multifocal bone lesions, three (9%) had bone lesions and diabetes insipidus, and seventeen (53%) had cutaneous and/or multisystem involvement. Age at diagnosis ranged from 2 days to 15 years. Read More
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    Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis.
    Eur J Endocrinol 2017 Aug;177(2):127-135
    Department of Clinical and Experimental MedicineSection of Endocrinology, University of Pisa, Pisa, Italy.
    Introduction: Autoimmune hypophysitis (AH) has a variable clinical presentation and natural history; likewise, its response to glucocorticoid therapy is often unpredictable.

    Objective: To identify clinical and radiological findings associated with response to glucocorticoids.

    Design And Methods: 12 consecutive patients with AH, evaluated from 2008 to 2016. Read More
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    Long-standing isolated autoimmune hypothalamitis diagnosed with endoscopic transventricular biopsy: a case report.
    World Neurosurg 2017 Jun 15. Epub 2017 Jun 15.
    Unit of Neurosurgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Via Francesco Sforza 35, 20122 Milan, Italy.
    Background: Autoimmune hypothalamitis, which is among the causes of acquired central diabetes insipidus, has been described very rarely in the literature. This condition is probably provoked by the production of anti-vasopressin secreting cells antibodies and anti-hypothalamus antibodies, and is often associated with pituitary or polyendocrine autoimmunity. Correct diagnosis and immediate treatment are essential in order to avoid the progression of the pathological process. Read More
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    Association between Ischemic Stroke and Erdheim-Chester Disease: A Case Report and Review of Literature.
    J Stroke Cerebrovasc Dis 2017 Jun 13. Epub 2017 Jun 13.
    Neurology Department, Meaux General Hospital, Meaux, France.
    Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by a xanthogranulomatous infiltration of tissues by spumous histiocytes. Neurological involvement is frequent, but ischemic strokes have been exceptionally described. We report the case of a 68-year-old woman who presented with an acute ischemic stroke associated with a multisystemic disorder including insipidus diabetes, infiltration of the aorta and the carotid arteries, perirenal infiltration, aortitis, and lytic bone lesions. Read More
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    Diabetes insipidus and hypopituitarism in HIV: an unexpected cause.
    Endocrinol Diabetes Metab Case Rep 2017 29;2017. Epub 2017 May 29.
    Endocrinology Department, Hospital de Egas Moniz, LisboaPortugal.
    Central diabetes insipidus (DI) is a rare clinical entity characterized by low circulating levels of antidiuretic hormone (ADH) presenting with polyuria and volume depletion. Pituitary surgery is the most common cause of central DI in adults. Pituitary and hypothalamic disease, particularly invasive neoplasms, rarely cause DI, being idiopathic cases responsible for the majority of non-surgical cases. Read More
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    Lithium-induced NDI: Acetazolamide reduces polyuria, but does not improve urine concentrating ability.
    Am J Physiol Renal Physiol 2017 Jun 14:ajprenal.00147.2017. Epub 2017 Jun 14.
    Radboud University Nijmegen Medical Centre
    Lithium is the mainstay treatment for patients with bipolar disorder, but generally causes nephrogenic diabetes insipidus (NDI), a disorder in which the renal urine concentrating ability has become vasopressin-insensitive. Li-NDI is caused by lithium uptake by collecting duct principal cells and downregulation of AQP2 water channels, which are essential for water uptake from pro-urine. Recently, we found that the prophylactic administration of acetazolamide to mice effectively attenuated Li-NDI. Read More
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    A case of acute Sheehan's syndrome and literature review: a rare but life-threatening complication of postpartum hemorrhage.
    BMC Pregnancy Childbirth 2017 Jun 14;17(1):188. Epub 2017 Jun 14.
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
    Background: Sheehan's syndrome occurs because of severe postpartum hemorrhage causing ischemic pituitary necrosis. Sheehan's syndrome is a well-known condition that is generally diagnosed several years postpartum. However, acute Sheehan's syndrome is rare, and clinicians have little exposure to it. Read More
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    Erdheim-Chester Disease Presenting with Secondary Hypertension as a Result of Bilateral, Proximal Renal Artery Stenosis: A Case Report.
    Case Rep Nephrol Dial 2017 May-Aug;7(2):55-62. Epub 2017 May 23.
    University of California, Los Angeles, California, USA.
    Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis presenting most commonly with bone and central nervous system symptoms, including but not limited to bone pain and diabetes insipidus. We present a known case of ECD, which was referred for secondary hypertension workup and diagnosed with severe, proximal, bilateral renal artery stenosis. Read More
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    Oral administration of diluted nasal desmopressin in managing neonatal central diabetes insipidus.
    J Pediatr Endocrinol Metab 2017 May 23. Epub 2017 May 23.
    .
    Background: Neonatal central diabetes insipidus (NCDI) remains a therapeutic challenge, as extremely low doses of enteral desmopressin cannot be titrated with current preparations. The aim of this study was to describe the use of orally administered dilute desmopressin in NCDI.

    Methods: Nasal desmopressin (100 μg/mL) was diluted in 0. Read More
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    Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability.
    Endocrine 2017 Jul 8;57(1):166-174. Epub 2017 Jun 8.
    Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, Cardiff, CF24 4HQ, UK.
    Purpose: Central diabetes insipidus is characterised by arginine vasopressin deficiency. Oxytocin is structurally related to vasopressin and is synthesised in the same hypothalamic nuclei, thus we hypothesised that patients with acquired central diabetes insipidus and anterior hypopituitarism would display an oxytocin deficiency. Moreover, psychological research has demonstrated that oxytocin influences social and emotional behaviours, particularly empathic behaviour. Read More
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    Opioid-induced hyponatremia in a patient with central diabetes insipidus: independence from ADH.
    J Pediatr Endocrinol Metab 2017 May;30(6):693-696
    .
    Hyponatremia can be a complication of opioid therapy, which has been postulated to occur secondary to inappropriate antidiuretic hormone secretion (syndrome of inappropriate antidiuretic hormone secretion [SIADH]). We report severe hyponatremia following wisdom teeth extraction with opioid analgesia in a 19-year-old female with diabetes insipidus (DI) and acquired panhypopituitarism that challenges this theory. As this patient has DI, we believe opioid treatment caused severe hyponatremia by the following mechanisms: (1) Opioids have a direct antidiuretic effect independent of changes in ADH, as demonstrated in Brattleboro rats with central DI. Read More
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    A reformed surgical treatment modality for children with giant cystic craniopharyngioma.
    Childs Nerv Syst 2017 Jun 7. Epub 2017 Jun 7.
    Department of Pediatric Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
    Objective: Surgical removal plays an important role in treating children's craniopharyngioma. For a safe and minimally invasive craniotomy, a reformed surgical modality was proposed in this paper by combining the insertion of an Ommaya reservoir system (ORS) by stereotactic puncture, aspiration of cystic fluid in 2-day interval for consecutive 7-10 days, and the delayed tumor resection.

    Patients And Methods: Eleven patients (aged from 5 to 9 years old) with giant cystic craniopharyngiomas who had undergone the reformed surgical modality during November 2014 and December 2015 were collected as group A. Read More
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    Hypothalamic hamartoma with epilepsy: Review of endocrine comorbidity.
    Epilepsia 2017 Jun;58 Suppl 2:50-59
    Pediatric Neurology Division and Hypothalamic Hamartoma Program, Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona, U.S.A.
    The most common, and usually the only, endocrine disturbance in patients with hypothalamic hamartoma (HH) and epilepsy is central precocious puberty (CPP). The mechanism for CPP associated with HH may relate to ectopic generation and pulsatile release of gonadotropin-releasing hormone (GnRH) from the HH, but this remains an unproven hypothesis. Possible regulators of GnRH release that are intrinsic to HH tissue include the following: (1) glial factors (such as transforming growth factor α[TGFα) and (2) γ-aminobutyric acid (GABA)-mediated excitation. Read More
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    Long term follow-up of growth hormone-secreting pituitary adenomas submitted to endoscopic endonasal surgery.
    Arq Neuropsiquiatr 2017 May;75(5):301-306
    Faculdade de Ciências Médicas, Santa Casa de São Paulo, Departamento de Otorrinolaringologia São Paulo SP, Brasil.
    Objective: The aim of this study was to evaluate the results of the endoscopic transsphenoidal technique for growth hormone (GH)-secreting adenomas.

    Methods: A retrospective analysis based on medical records of 23 acromegalic patients submitted to endoscopic transsphenoidal surgery. Biochemical control was defined as basal GH < 1ng/ml, nadir GH < 0. Read More
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    Intraoperative Dexmedetomidine-Induced Polyuric Syndrome.
    Cureus 2017 May 3;9(5):e1218. Epub 2017 May 3.
    Anesthesiology, Riverside University Health System Medical Center, Moreno Valley, California, United States.
    A 23-year-old male trauma patient with a cervical spine fracture underwent an anterior and posterior discectomy and spinal fusion surgery. The patient presented to the operating room with a stabilizing halo fixation device in place, and a fiberoptic intubation was performed with dexmedetomidine for sedation. During the surgical procedure, general anesthesia was maintained with a propofol and remifentanil infusion as the patient was monitored using somatosensory and motor evoked potentials. Read More
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    Xanthomatous Hypophysitis Presenting With Diabetes Insipidus Completely Cured Through Transsphenoidal Surgery: A Case Report and Literature Review.
    World Neurosurg 2017 Jun 2. Epub 2017 Jun 2.
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Beijing 100730, People's Republic of China. Electronic address:
    Background: Xanthomatous hypophysitis (XH) is extremely rare. Only 27 cases have been reported in the literature. No XH patient presenting with diabetes insipidus (DI) has been completely cured through surgery. Read More
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    Infected colloid cyst.
    Childs Nerv Syst 2017 Jun 3. Epub 2017 Jun 3.
    Neurosurgery Department, Mustafa Kemal University, Hatay, Turkey.
    Introduction: Colloid cysts are the most common pathologic lesions of the third ventricle. Although they are histologically benign, they may grow and can cause the hydrocephalus. A 5-year-old male patient underwent to surgery with the diagnosis of colloid cyst. Read More
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    Regulation of renal Na-(K)-Cl cotransporters by vasopressin.
    Pflugers Arch 2017 Jun 2. Epub 2017 Jun 2.
    Department of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Vasopressin (AVP) induces antidiuresis, thus playing an essential role in body water and electrolyte homeostasis. Its antidiuretic effects are mediated chiefly by V2 vasopressin receptors (V2R) expressed along the distal nephron and collecting duct epithelia. NaCl reabsorption in the distal nephron, which includes the thick ascending limb (TAL) and distal convoluted tubule (DCT), largely depends on the activity of two structurally related Na-(K)-Cl cotransporters, NKCC2 in TAL and NCC in DCT. Read More
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    A Case of Kidney Involvement in Primary Sjögren's Syndrome.
    Am J Case Rep 2017 Jun 3;18:622-626. Epub 2017 Jun 3.
    Department of Medicine, University of California, Los Angeles, CA, USA.
    BACKGROUND Sjögren's syndrome is an autoimmune disorder caused by the infiltration of monocytes in epithelial glandular and extra-glandular tissues. Hallmark presentations include mouth and eye dryness. Although renal involvement is uncommon in primary Sjögren's syndrome (pSS), patients may experience renal tubular acidosis type I (RTA I), tubulointerstitial nephritis, diabetes insipidus (DI), nephrolithiasis, and Fanconi syndrome. Read More
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    A Case of Osteomyelitis of the toe caused by Coccidioidomycosis in a 17 year-old with Diabetes Insipidus.
    IDCases 2017 3;9:14-16. Epub 2017 May 3.
    Kaweah Delta Health Care District, 400 West Mineral King Avenue, Visalia, CA 93291, United States.
    We report a case of a 17-year-old male who presented with pain in his right first toe. His pain and swelling had worsened and x-rays of his foot revealed erosive changes of the great toe distal phalanx suggesting possible osteomyelitis. His co-morbidities were morbid obesity and diabetes insipidus. Read More
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    The clinical spectrum of Erdheim-Chester disease: an observational cohort study.
    Blood Adv 2017 Feb;1(6):357-366
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health. 10 Center Dr, Bldg 10, Room 3-2551, Bethesda, Maryland, USA, 20892. Telephone: 301-594-2952.
    Erdheim-Chester Disease (ECD) is a rare, potentially fatal, multi-organ myeloid neoplasm occurring mainly in adults. The diagnosis is established by clinical, radiologic, and histologic findings; ECD tumors contain foamy macrophages that are CD68+, CD163+, CD1a-, and frequently S100-. The purpose of this report is to describe the clinical and molecular variability of ECD. Read More
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    Use of Chlorothiazide in the Management of Central Diabetes Insipidus in Early Infancy.
    Case Rep Pediatr 2017 3;2017:2407028. Epub 2017 May 3.
    Department of Pediatrics, Division of Pediatric Endocrinology, New York University School of Medicine, New York, NY, USA.
    Management of central diabetes insipidus in infancy is challenging. The various forms of desmopressin, oral, subcutaneous, and intranasal, have variability in the duration of action. Infants consume most of their calories as liquids which with desmopressin puts them at risk for hyponatremia and seizures. Read More
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    IgG4-Related Disease Manifesting as Interstitial Nephritis Accompanied by Hypophysitis.
    Am J Case Rep 2017 May 29;18:593-598. Epub 2017 May 29.
    Department of Nephrology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan.
    BACKGROUND IgG4-related disease is a systemic disease with marked infiltration of IgG4-positive plasma cells into affected organs and elevated serum IgG4. On clinical examination, swelling, nodules, and hypertrophic lesions might appear simultaneously or metachronously in different organs. CASE REPORT An 85-year-old man with sudden-onset polydipsia and polyuria insipidus was transported to our hospital because of hypothermia and general malaise. Read More
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    Successful Treatment of Pituitary Germinoma with Etoposide, Cisplatin, Vincristine, Methotrexate and Bleomycin Chemotherapy Without Radiotherapy.
    Anticancer Res 2017 06;37(6):3111-3115
    Department of Medical Oncology, University Hospital Bern, Bern, Switzerland
    We report on the case of a 25-year-old man with pituitary germinoma. The patient had noticed polydipsia, reduced sexual function, and loss of body hair. Laboratory investigations confirmed panhypopituitarism including diabetes insipidus. Read More
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    Pituitary dysfunction in granulomatosis with polyangiitis.
    Pituitary 2017 May 24. Epub 2017 May 24.
    Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Purpose: Granulomatosis with polyangiitis (GPA) is a multisystem disease, characterized by necrotizing small-vessel vasculitis, which mainly affects the respiratory tract and the kidneys. Pituitary involvement in GPA is rare, present in about 1% of all cases of GPA. To date, only case reports or small case series have been published. Read More
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    Lymphocytic Hypophysitis Mimicking Pituitary Macroadenoma.
    J Assoc Physicians India 2017 Apr;65(4):85-86
    Residents, RNT Medical College, Udaipur, Rajasthan.
    Lymphocytic hypophysitis is an inflammatory /autoimmune disorder that primarily involves the pituitary gland and the pituitary stalk. The common clinical presentations include headache, nausea, vomiting, fatigue, features of hypopituitarism and diabetes insipidus as well as diplopia, orbital pain and bitemporal hemianopia. We report a case of lymphocytic hypophysitis which presented as hemichorea. Read More
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    Xanthoma Disseminatum in a Young Patient with Diabetes Insipidus.
    Pediatr Dermatol 2017 May;34(3):e144-e145
    Department of Dermatology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
    Xanthoma disseminatum (XD) is a nonfamilial type of normolipidemic mucocutaneous xanthomatosis that belongs to the group of non-Langerhans cell histiocytoses. More than 100 cases of XD have been reported. In this study we report a case of XD in a 4-year-old boy with diabetes insipidus (DI). Read More
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    Endocrine Disorders Developing after Surgical Intervention of Craniopharyngioma in Children.
    Pediatr Endocrinol Rev 2017 Mar;14(3):298-301
    Child Psychiatry Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Craniopharyngiomas, albeit their benign nature, can cause severe damage to visual, hypothalamic, endocrine and neurologic functions which make their total resection an inevitable approach to save the patient's life. However, significant therapy-related long term complications make those traditional treatment options debatable and hazardous. This review will focus on the various complications that affect the childrens' quality of life considerably such as, diabetes insipidus, precocious puberty and hypothalamic obesity. Read More
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    Adipsic diabetes insipidus revealing a bifocal intracranial germinoma.
    Ann Endocrinol (Paris) 2017 May 5. Epub 2017 May 5.
    Department of Endocrinology, CHU de Liège, University of Liège, 4000 Liège, Belgium. Electronic address:
    Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in the literature. Read More
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    Genetics of Diabetes Insipidus.
    Endocrinol Metab Clin North Am 2017 Jun 28;46(2):305-334. Epub 2017 Feb 28.
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, Vienna 1090, Austria.
    Diabetes insipidus is a disease characterized by polyuria and polydipsia due to inadequate release of arginine vasopressin from the posterior pituitary gland (neurohypophyseal diabetes insipidus) or due to arginine vasopressin insensitivity by the renal distal tubule, leading to a deficiency in tubular water reabsorption (nephrogenic diabetes insipidus). This article reviews the genetics of diabetes insipidus in the context of its diagnosis, clinical presentation, and therapy. Read More
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    Outcome of Endoscopic Transsphenoidal Surgery for Acromegaly.
    World Neurosurg 2017 Apr 29. Epub 2017 Apr 29.
    Pituitary Center; Department of Neurosurgery, Seoul National University College of Medicine. Electronic address:
    Objective: Endoscopic transsphenoidal surgery has recently been introduced in pituitary surgery. We investigated outcomes and complications of endoscopic surgery in two referral centers in Korea.

    Methods: We enrolled 134 patients with acromegaly (microadenomas, n=15; macroadenomas, n=119) who underwent endoscopic transsphenoidal surgery at Seoul National University Hospital (n=74) and Samsung Medical center (n=60) between Jan 2009 and Mar 2016. Read More
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    ILDR1 is important for paracellular water transport and urine concentration mechanism.
    Proc Natl Acad Sci U S A 2017 May 1;114(20):5271-5276. Epub 2017 May 1.
    Department of Internal Medicine, Washington University in St. Louis, St. Louis, MO 63110;
    Whether the tight junction is permeable to water remains highly controversial. Here, we provide evidence that the tricellular tight junction is important for paracellular water permeation and that Ig-like domain containing receptor 1 (ILDR1) regulates its permeability. In the mouse kidney, ILDR1 is localized to tricellular tight junctions of the distal tubules. Read More
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    Fully endoscopic combined transsphenoidal and supraorbital keyhole approach for parasellar lesions.
    J Neurosurg 2017 Apr 28:1-10. Epub 2017 Apr 28.
    Department of Neurosurgery, Nagoya University Graduate School of Medicine; and.
    OBJECTIVE Parasellar tumors that extend far laterally beyond the internal carotid artery or that are fibrous and adhere firmly to critical structures are difficult to remove totally via the endoscopic transsphenoidal approach alone. In such cases, a combined transsphenoidal-transcranial approach is effective to achieve maximal resection in a single stage. In this paper, a new minimally invasive surgical technique for complicated parasellar lesions, a fully endoscopic combined transsphenoidal-supraorbital keyhole approach, is presented. Read More
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    Microscopic surgery for pituitary adenomas to preserve the pituitary gland and stalk.
    Exp Ther Med 2017 Mar 19;13(3):1011-1016. Epub 2017 Jan 19.
    Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
    Surgery is the primary treatment of choice for all symptomatic pituitary adenomas except prolactinomas. Common postoperative complications include endocrinopathies, vision impairment and cerebrospinal fluid leak. The present study assessed 153 continuous microscopic surgeries for pituitary adenomas performed by an author of the present study between 2010 to 2014. Read More
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    Familial hyperaldosteronism type III.
    J Hum Hypertens 2017 Apr 27. Epub 2017 Apr 27.
    Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
    Primary aldosteronism is the most common form of endocrine hypertension. This disorder comprises both sporadic and familial forms. Four familial forms of primary aldosteronism (FH-I to FH-IV) have been described. Read More
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    Binostril endoscopic transsphenoidal neurosurgery for pituitary adenomas: experience with 42 patients.
    Oncotarget 2017 Apr 9. Epub 2017 Apr 9.
    Department of Neurosurgery, The First People's Hospital of Yancheng, Yancheng, P R China.
    Here we review the technical aspects of our experience with the neuroendoscopic bilateral nostril (binostril) transsphenoidal approach for pituitary adenomas. A total of 42 patients were treated in our hospital from September 2013 to December 2015. Total tumor resection was completed in 31 cases, nearly full resection was achieved in 9 cases, and partial resection was achieved in 2 cases. Read More
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    Clinical presentation and outcome of children with central diabetes insipidus associated with a self-limited or transient pituitary stalk thickening, diagnosed as infundibuloneurohypophysitis.
    Clin Endocrinol (Oxf) 2017 Apr 26. Epub 2017 Apr 26.
    Division of Pediatric Endocrinology, UZ Gent, Gent, Belgium.
    Objective: Despite lymphocytic or autoimmune infundibuloneurohypophysitis (INH) is an increasingly recognized aetiology in children with central diabetes insipidus (CDI); clinical data on epidemiology (clinical evolution, predisposing factors, complications), diagnosis and management of this entity are limited and mostly based on published case reports. The aim of this study was to gain a broader insight in the natural history of this disease by analysing the clinical presentation, radiological pituitary stalk changes, associated autoimmunity and hormonal deficiencies in children with CDI and a self-limiting or transient stalk thickening (ST), diagnosed as autoimmune infundibuloneurohypophysitis, during the last 15 years in four Belgian university hospitals.

    Design And Patients: The medical files of nine CDI patients with a ST at initial presentation and no signs of Langerhans cell histiocytosis or germinoma at presentation and/or during follow-up of more than 1. Read More
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    Late outcomes in children with Langerhans cell histiocytosis.
    Arch Dis Child 2017 Apr 25. Epub 2017 Apr 25.
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
    Introduction: Langerhans cell histiocytosis (LCH) is a rare disease with diverse clinical courses. Despite improvement in survival outcomes in the recent decades, sequelae of the disease remain a concern. This study aimed to provide information on the long-term outcomes in patients with LCH, particularly on the sequelae and any associated factors. Read More
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    Presenting Symptoms of Pituitary Apoplexy.
    J Neurol Surg A Cent Eur Neurosurg 2017 Apr 24. Epub 2017 Apr 24.
    Department of Internal Medicine, Sotiria General Hospital of Chest Diseases, Athens, Greece.
    The classical term "pituitary apoplexy" (PA) describes a clinical syndrome usually characterized by abrupt onset of headache accompanied by neurologic and/or endocrinologic deterioration due to sudden expansion of a mass within the sella turcica as a result of hemorrhage or infarction within a pituitary tumor and adjacent pituitary gland. PA is a medical emergency and a difficult diagnosis to establish. Thus this article reviews the presenting symptoms of PA patients to help clinicians recognize or at least suspect this critical condition early on. Read More
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    Clinical Outcome after Extended Endoscopic Endonasal Resection of Craniopharyngiomas: Two-institution Experience.
    World Neurosurg 2017 Apr 19. Epub 2017 Apr 19.
    Department of Neurological Surgery, Philadelphia, Pennsylvania. Electronic address:
    Background: The extended endoscopic endonasal approach (EEA) to the anterior cranial base is used for the resection of craniopharyngiomas.

    Objective: We present clinical experience and outcomes utilizing EEA for craniopharyngiomas.

    Methods: A total of 116 patients in two remote institutions were enrolled in this retrospective study. Read More
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    Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18 years.
    Clin Endocrinol (Oxf) 2017 Apr 19. Epub 2017 Apr 19.
    Key Laboratory of Endocrinology of National Health and Family Planning Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Objective: Primary lymphocytic hypophysitis (LYH) is rare, and it is often evaluated in a small case series. This study aimed to describe the diagnosis and treatment of primary LYH in a larger cohort.

    Design: A retrospective study of the diagnosis and treatment of primary LYH was conducted at Peking Union Medical College Hospital from 1999 to 2016. Read More
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    Usefulness of anti-rabphilin-3A antibodies for diagnosing central diabetes insipidus in the third trimester of pregnancy.
    Endocr J 2017 Apr 14. Epub 2017 Apr 14.
    Department of Endocrinology and Applied Medical Science, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
    We report a 27-year-old pregnant woman with polyuria, polydipsia and headache in the third trimester of pregnancy. Hypernatremia (153 mEq/L), high plasma osmolality (300 mOsm/kgH2O) and low urinary osmolality (92 mOsm/kgH2O) were observed at the admission to our hospital. Plasma arginine vasopressin (AVP) level was inappropriately low (2. Read More
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    Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene.
    Stem Cell Res 2017 Mar 24;19:37-42. Epub 2016 Dec 24.
    Department of Biomedicine, Aarhus University, Bartholins Allé 6, 8000 Aarhus C, Denmark.
    Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by variants in the arginine vasopressin (AVP) gene. Here we report the generation of induced pluripotent stem cells (iPSCs) from a 42-year-old man carrying an adFNDI causing variant in exon 1 of the AVP gene using lentivirus-mediated nuclear reprogramming. The iPSCs carried the expected variant in the AVP gene. Read More
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    Endocrine Comorbidities in Patients with Psoriatic Arthritis: A Population-based Case-controlled Study.
    J Rheumatol 2017 Jun 15;44(6):786-790. Epub 2017 Apr 15.
    From the Department of Rheumatology, and the Department of Internal Medicine, and the Department of Community Medicine and Epidemiology, Carmel Medical Center; Bruce and Ruth Rappaport Faculty of Medicine Technion, Haifa; Chief Physician's Office, Central Headquarters, Clalit Health Services, Tel Aviv; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba, Israel.
    Objective: To investigate endocrine comorbidities in patients with psoriatic arthritis (PsA).

    Methods: A retrospective, cross-sectional study was performed with the database of Clalit Health Services, the largest healthcare provider in Israel, between 2002 and 2014. Patients with PsA were identified and matched by age and sex to healthy controls. Read More
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    Complete endoscopic resection of a pituitary stalk epidermoid cyst using a combined infrasellar interpituitary and suprasellar endonasal approach: case report.
    J Neurosurg 2017 Apr 14:1-7. Epub 2017 Apr 14.
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and.
    Intracranial epidermoid cysts are benign lesions of epithelial origin that most frequently present with symptoms of mass effect. Although they are often associated with a high rate of residual tumor and recurrence, maximal safe resection usually leads to good outcomes. The authors report a complete resection of an uncommon pituitary stalk epidermoid cyst with intrasellar extension using a combined suprasellar and infrasellar interpituitary, endoscopic endonasal transsphenoidal approach. Read More
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