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Surg Neurol Int 2021 21;12:296. Epub 2021 Jun 21.

Departments of Neurosurgery and Radiology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, United States.

Background: Hemangioblastomas are benign (World Health Organization Grade I), highly vascular neoplasms commonly associated with Von Hippel-Lindau (VHL) disease.[2] The VHL tumor-suppressor gene, located on chromosome 3, is implicated in sporadic cases and cases associated with VHL disease. Hemangioblastomas most commonly arise in the posterior fossa; however, they may also be found supratentorially or within the spinal cord. Read More

BMC Endocr Disord 2022 May 19;22(1):134. Epub 2022 May 19.

Endocrinology Department, AJA University of Medical Science, Tehran, Iran.

Background: Novel coronavirus disease 2019 (COVID-19) mainly affects the lungs, but can involve several other organs. The diagnosis of acute and chronic sequelae is one of the challenges of COVID-19. The current literature proposes that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may involve the hypothalamic-pituitary axis. Read More

J Pediatr Endocrinol Metab 2022 May 19. Epub 2022 May 19.

Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.

Objectives: Endocrinopathy can occur as a postoperative sequel in children treated for supratentorial tumors (STTs). We assessed prediction of a residual hypothalamic/pituitary insufficiency (HPI) in these patients and factors associated with prolonged length of hospital stay (LOS).

Methods: This is a retrospective cohort study of children who had surgery for STTs in two tertiary centers in Saudi Arabia (2009-2019). Read More

Intern Med 2022 May 14. Epub 2022 May 14.

Division of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Japan.

Background Pituitary inflammation due to IgG4-related disease is a rare condition and is sometimes accompanied by central diabetes insipidus. Central diabetes insipidus produces a strong thirst sensation, which may be difficult to distinguish when complicated by salivary insufficiency. Case presentation A 45-year-old man was admitted to our department for a thorough examination of his thirst and polyuria. Read More

Rev Neurol (Paris) 2022 May 11. Epub 2022 May 11.

Affiliated Hospital of North Sichuan Medical College Nanchong, 637000 Sichuan, China.

Neurosurg Rev 2022 May 14. Epub 2022 May 14.

Department of Neurosurgery, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

This series sought to evaluate the role of intraoperative MRI (iMRI) for resection of functional pituitary adenomas (FPAs). We retrospectively reviewed clinical data of 114 consecutive FPAs with excessive hormone secretion treated with transsphenoidal surgery and iMRI during 01/2010-12/2017. We focused on iMRI findings, extend of resection and postoperative hormonal remission. Read More

J Clin Med 2022 Apr 29;11(9). Epub 2022 Apr 29.

Department of Perioperative Medicine, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France.

Background: Volatile anesthetics were used as sedative agents in COVID-19 (Coronavirus Disease 2019) invasively ventilated patients for their potentially beneficial pharmacological effects and due to the temporary shortages of intravenous agents during the pandemic crisis.

Methods: Online databases (PubMed, EMBASE, The Cochrane Central Register of Controlled Trial) and the "clinicaltrials.gov" website were searched for studies reporting the use of isoflurane, sevoflurane or desflurane. Read More

Endocr Connect 2022 May 1. Epub 2022 May 1.

Y Zhao, Huashan Hospital Fudan University, Shanghai, China.

Introduction: Most studies reporting posterior pituitary tumors (PPTs) are small case series or single cases.

Methods: Patients with a histological diagnosis of PPT from January 2010 to December 2021 in a tertiary center were identified. We reported clinical symptoms, endocrine assessments, radiological and pathological features, and surgical outcomes of PPTs. Read More

BMC Nephrol 2022 May 12;23(1):182. Epub 2022 May 12.

Nephrology Department, Heraklion University Hospital, Voutes, 71500, Heraklion, Crete, Greece.

Background: Dent disease is an X-linked disorder characterized by low molecular weight proteinuria (LMWP), hypercalciuria, nephrolithiasis and chronic kidney disease (CKD). It is caused by mutations in the chloride voltage-gated channel 5 (CLCN5) gene (Dent disease-1), or in the OCRL gene (Dent disease-2). It is associated with chronic metabolic acidosis; however metabolic alkalosis has rarely been reported. Read More

NPJ Syst Biol Appl 2022 May 9;8(1):16. Epub 2022 May 9.

University of Applied Sciences Mittweida, Mittweida, 09648, Germany.

The response of cells to their environment is driven by a variety of proteins and messenger molecules. In eukaryotes, their distribution and location in the cell are regulated by the vesicular transport system. The transport of aquaporin 2 between membrane and storage region is a crucial part of the water reabsorption in renal principal cells, and its malfunction can lead to Diabetes insipidus. Read More

Acta Neurochir (Wien) 2022 May 7. Epub 2022 May 7.

Department of Endocrinology, University College London Hospitals NHS Foundation Trust, London, UK.

Purpose: IgG4-related hypophysitis (IgG4-RH) is a rare chronic inflammatory condition of the pituitary gland. This study reports the presentation, management and outcomes for patients with histologically proven IgG4-related hypophysitis.

Methods: A prospectively maintained electronic database was searched over a 14-year period from 1 January 2007 to 31 December 2020 at a single academic centre to identify all patients with a histological diagnosis of IgG4-RH. Read More

Neurol India 2022 Mar-Apr;70(2):600-605

Department of Endocrinology (Pediatric), Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Craniopharyngiomas are associated with long-term morbidity in the form of hormone deficiencies, visual deficits, and hypothalamic obesity.

Objective: To study the long-term outcomes, including cure rates, endocrine dysfunction, visual dysfunction, hypothalamic obesity, and mortality in pediatric-onset craniopharyngiomas.

Methods: A retrospective data analysis of pediatric (onset <18 years) craniopharyngioma diagnosed between 2003 and 2018. Read More

Br J Neurosurg 2022 May 8:1-3. Epub 2022 May 8.

Consultant ENT & Skull Base Surgeon, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

Lithium is a psychotropic drug used primarily in the treatment of bipolar disorder. It is renally excreted and characteristically causes nephrogenic diabetes insipidus as an adverse drug reaction. Lithium also requires serum level monitoring as there is a narrow therapeutic window and untreated toxicity can result in neurological sequelae including drowsiness, coma, seizures, and ultimately death. Read More

J Endocr Soc 2022 Jun 6;6(6):bvac053. Epub 2022 Apr 6.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892, USA.

Context: Arginine-vasopressin and CRH act synergistically to stimulate secretion of ACTH. There is evidence that glucocorticoids act via negative feedback to suppress arginine-vasopressin secretion.

Objective: Our hypothesis was that a postoperative increase in plasma copeptin may serve as a marker of remission of Cushing disease (CD). Read More

Lancet 2022 05;399(10337):1809

Department of Medicine, Division of Endocrinology, National University Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Eur J Endocrinol 2022 May 12;187(1):65-74. Epub 2022 May 12.

Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.

Background: The differential diagnosis of diabetes insipidus is challenging. The most reliable approaches are copeptin measurements after hypertonic saline infusion or arginine, which is a known growth hormone secretagogue but has recently also been shown to stimulate the neurohypophysis. Similar to arginine, glucagon stimulates growth hormone release, but its effect on the neurohypophysis is poorly studied. Read More

Surg Neurol Int 2022 31;13:119. Epub 2022 Mar 31.

Department of Neurosurgery, Centre for Skull Base and Pituitary Neurosurgery, Bristol Institute of Clinical Neuroscience, Southmead Hospital, Bristol, United Kingdom.

Background: Thyrotropinomas (TSHoma) are rare pituitary adenomas.

Case Description: A 34-year-old female presented with mild bitemporal field defect in third trimester with intact pituitary function. MRI demonstrated an enhancing lesion from the posterior planum to suprasellar, interpeduncular and prepontine cisterns with chiasmal compression and right fetal posterior communicating artery encasement. Read More

Int Forum Allergy Rhinol 2022 Apr 29. Epub 2022 Apr 29.

Department of Otorhinolaryngology-Head & Neck Surgery, University of Pennsylvania, Health System, Philadelphia, Pennsylvania, USA.

Background: Craniopharyngiomas have traditionally been treated via open transcranial approaches. More recent, endoscopic endonasal approaches have been increasingly used; however, there has been limited evaluation of long-term outcomes for this approach.

Methods: A retrospective review was performed to analyze patients with pediatric craniopharyngioma undergoing endonasal endoscopic resection from 2012 to 2020. Read More

Neuro Oncol 2022 Apr 27. Epub 2022 Apr 27.

Department of Pediatrics, University of California, San Francisco, CA, USA.

Background: To estimate the incidence of endocrinopathy in children and adolescents with craniopharyngioma after treatment with photon-based conformal and intensity-modulated radiation therapy (CRT).

Methods: 101 pediatric patients were enrolled on a phase II single-institution protocol beginning in 1998 (n=76) or followed a similar non-protocol treatment plan (n=25). Surgery was individualized. Read More

Cureus 2022 Mar 24;14(3):e23438. Epub 2022 Mar 24.

Nephrology, AMITA Health Saint Francis Hospital, Evanston, USA.

Lithium is a commonly used medication for mood stabilization and a well-known cause of nephrogenic diabetes insipidus (DI). Coexistent psychogenic polydipsia with nephrogenic DI is uncommon, and its management is challenging due to the wide variation in serum sodium based on fluctuations in water intake. Here, we describe the case of a 56-year-old male with psychogenic polydipsia and nephrogenic DI which manifested in wide swings of serum sodium over a short interval. Read More

Front Neurol 2022 11;13:847418. Epub 2022 Apr 11.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Object: Although revision surgery for recurrent craniopharyngiomas is more challenging than primary surgery and often accompanies a higher risk of death and complications, endoscopic endonasal transsphenoidal surgery (EETS) is sometimes still an effective and reliable treatment option. In this study, we introduced the surgical outcomes of EETS for recurrent craniopharyngiomas and summarized the surgical experiences.

Methods: Between 2014 and 2018, 28 patients with recurrent craniopharyngiomas underwent 29 EETS in our department. Read More

Endocr Pract 2022 Apr 24. Epub 2022 Apr 24.

ASCO Representative, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York.

Objective: The aim of this case-based clinical review is to provide a practical approach for clinicians regarding the management of patients with immune checkpoint inhibitor (ICI)-mediated endocrinopathies.

Methods: A literature search was conducted using PubMed, Embase and Scopus, and appropriate keywords. The discussions and strategies for diagnosis and management of ICI-mediated endocrinopathies are based on evidence available from prospective randomized clinical studies, cohort studies, cross-sectional studies, case-based studies, and expert consensus. Read More

J Neurol Sci 2022 Jun 20;437:120267. Epub 2022 Apr 20.

Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, Division of Neurology, University of Toronto, Ontario, Canada. Electronic address:

Wolfram Syndrome (WS) is a rare progressive hereditary neurodegenerative disease with hallmark features of diabetes mellitus, optic atrophy, and hearing loss. Its other clinical manifestations may include diabetes insipidus, urological, neurological, and psychiatric abnormalities. We review systemic and ocular manifestations of WS as well as its pathophysiology, diagnostic approach, and treatment options. Read More

J Pediatr Endocrinol Metab 2022 Apr 26. Epub 2022 Apr 26.

NIHR Biomedical Research Centre (Nutrition Theme), University of Bristol, Bristol, UK.

Objectives: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation, and neural-crest tumour (ROHHAD(NET)) is a rare syndrome presenting in early childhood associated with high morbidity and mortality. There is no specific diagnostic biomarker and diagnosis is based on clinical features. An autoimmune origin has been postulated. Read More

Brain Dev 2022 Apr 22. Epub 2022 Apr 22.

Research Institute of the McGill University Medical Centre, Montreal, Quebec, Canada; Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

Background: Chromosome 18q duplications are associated with a range of phenotypes often similar to complete trisomy 18, variably including poor growth, feeding difficulties, congenital malformations and dysmorphic facial features. Although 18q duplication patients may have seizures and developmental impairment, brain MRI typically shows only variable degrees of cerebral atrophy.

Patient: We present a boy with a 52. Read More

J Obstet Gynaecol 2022 Apr 26:1-3. Epub 2022 Apr 26.

Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.

Front Neurol 2022 7;13:880312. Epub 2022 Apr 7.

Department of Neuroradiology, Pierre-Paul-Riquet/Purpan University Hospital, Toulouse, France.

Erdheim-Chester disease (ECD) is a rare histiocytic disorder, recently recognized to be neoplastic. The clinical phenotype of the disease is extremely heterogeneous, and depends on the affected organs, with the most frequently reported manifestations being bone pain, diabetes insipidus and neurological disorders including ataxia. In this article, we report on a case of a 48-year-old woman, whose initial symptom of gait instability was isolated. Read More

Asian J Surg 2022 Apr 18. Epub 2022 Apr 18.

Department of Pain Management, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, PR China. Electronic address:

J Pediatr Hematol Oncol 2022 05 25;44(4):159-166. Epub 2022 Mar 25.

Division of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.

Patients with childhood brain tumors are at risk of endocrine disorders. The prevalence of endocrine disorders varies across the world but is unknown in Malaysia. This study's objectives were to determine the prevalence of endocrine disorders among children with brain tumors in Malaysia and to identify endocrinopathy-associated risk factors. Read More