657,440 results match your criteria Diabetes & Vascular Disease Research[Journal]


Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes.

Ann Nutr Metab 2019 Feb 14;74(2):165-174. Epub 2019 Feb 14.

Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, Nevada,

Background: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes.

Objective: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497226DOI Listing
February 2019

Porphyromonas gingivalis promotes the motility of esophageal squamous cell carcinoma by activating NF-κB signaling pathway.

Microbes Infect 2019 Feb 11. Epub 2019 Feb 11.

Guangdong Provincial Institute of Geriatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China; Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Esophageal carcinoma, with a increasing incidence, is one of the most aggressive carcinomas in gastrointestinal tract. Epidemiologic studies demonstrate an association of oral pathogens with multiple diseases, including rheumatoid arthritis, cardiovascular diseases, diabetes, and gastrointestinal malignancies. Nevertheless, a causal relationship between oral pathogens and esophageal squamous cell carcinoma (ESCC) has not been elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micinf.2019.01.005DOI Listing
February 2019

Posterior Cervical Decompression and Fusion: Assessing Risk Factors for Nonhome Discharge and the Impact of Disposition on Postdischarge Outcomes.

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurosurgery, Mount Sinai Hospital, New York, NY, USA; Department of Orthopedics, Mount Sinai Hospital, New York, NY, USA.

Background: The purpose of this study was to identify predictors for post-acute care facility discharge for patients undergoing posterior cervical decompression and fusion (PCDF), and to determine if discharge placement impacts post-discharge outcomes.

Methods: Patients undergoing PCDF from 2012-2015 were queried from the NSQIP database (n=8,743) and separated by discharge placement. Outcomes included non-home discharge, unplanned 30-day readmission, and adverse events (AE), both pre- and post-discharge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.01.214DOI Listing
February 2019

Comparative Analysis Using Propensity Score Matching Analysis: Primary Closure Versus Patch Angioplasty During Carotid Endarterectomy.

Ann Vasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Division of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Background: Primary closure (PC) and patch angioplasty (PA) during carotid endarterectomy (CEA) have been disputed in many studies. Some studies announced that PC is associated with a higher restenosis rate. The aim of this study was to evaluate the outcomes of PC and PA using propensity score matching (PSM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2018.11.011DOI Listing
February 2019

Glycaemic variability is associated with severity of coronary artery disease in patients with poorly controlled type 2 diabetes and acute myocardial infarction.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Cardiology Department, University Hospital Center Dijon Bourgogne, France.

Background: - In patients with type 2 diabetes (T2D), glycaemic variability (GV), another component of glycaemic abnormalities, is a novel potentially aggravating factor for coronary artery disease (CAD).

Objectives: - The aim of our study was to identify interactions between GV and severity of CAD in diabetes patients admitted for acute myocardial infarction (AMI).

Methods: - All patients with T2D admitted to our university hospital for AMI from March 2015 to February 2017 who received intravenous (IV) insulin therapy and underwent coronary angiography were included. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S12623636193002
Publisher Site
http://dx.doi.org/10.1016/j.diabet.2019.01.012DOI Listing
February 2019
1 Read

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University Hospital of Verona, Verona, Italy. Electronic address:

Aim: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD.

Methods: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diabet.2019.01.011DOI Listing
February 2019

Can the gastric healing effect of Eugenia punicifolia be the same in male and female rats?

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Department of Physiology, Biosciences Institute, UNESP-São Paulo State University CEP 18618-689, Botucatu, São Paulo, Brazil. Electronic address:

Ethnopharmacological Relevance: Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used as a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, and gastroprotective effects have already been characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.012DOI Listing
February 2019

Lysophosphatidic acid receptor 1 inhibitor, AM095, attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB signaling and NADPH oxidase.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 11. Epub 2019 Feb 11.

College of Pharmacy, Gachon University, Incheon, Republic of Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea; Gachon University Gil Medical Center, Gachon Medical and Convergence Institute, Incheon, Republic of Korea. Electronic address:

Diabetic nephropathy (DN) is one of the major long-term complications of diabetes. Lysophosphatidic acid (LPA) signaling has been implicated in renal fibrosis. In our previous study, we found that the LPA receptor 1/3 (LPAR1/3) antagonist, ki16425, protected against DN in diabetic db/db mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2019.02.001DOI Listing
February 2019

A scoring assessment tool for the risk of vertebral fractures in patients with type 2 diabetes mellitus.

Bone 2019 Feb 11. Epub 2019 Feb 11.

Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693-8501, Japan. Electronic address:

Background: Development of assessment tool for fracture risk is an urgent task, because bone mineral density (BMD) is less useful for evaluating fracture risk in type 2 diabetes mellitus (T2DM).

Subjects And Methods: In total, 808 T2DM patients were enrolled in this cross-sectional study. To develop a scoring assessment tool using clinical risks for vertebral fracture (VF), we evaluated which variables were associated with VF by logistic regression analysis, and categorized these variables based on cut-off values obtained by using receiver operating characteristic (ROC) curves. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2019.02.003DOI Listing
February 2019

Short-Term Effects of Intravitreal Bevacizumab in Contrast Sensitivity of Patients with Diabetic Macular Edema and Optimizing Glycemic Control.

Diabetes Res Clin Pract 2019 Feb 11. Epub 2019 Feb 11.

Division of Ophthalmology, University of São Paulo, São Paulo Medical School, São Paulo, Brazil.

Aims: To analyze contrast sensitivity of intravitreal bevacizumab injections with optimizing glycemic control versus optimizing glycemic control (in combination with sham injections) in eyes with diabetic macular edema (DME) DESIGN: Prospective, interventional, masked, randomized controlled trial.

Methods: Forty-one eyes of 34 patients with type 2 diabetes mellitus and DME with glycated hemoglobin (HbA1c) <11% received either intravitreal bevacizumab injection (Group 1) or sham injection (Group 2) at 0 and 6 weeks along with optimizing glycemic control. Mean change in best-corrected visual acuity (BCVA), contrast sensitivity (CS), optical coherence tomography (OCT)-measured by central macular thickness (CMT) were compared and correlated at baseline, 2, 6 and 12 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diabres.2019.02.002DOI Listing
February 2019

[Laryngeal Tuberculosis Diagnosed in a Pathological Laboratory in Senegal (2011-2015)].

Bull Soc Pathol Exot 2018 ;111(1):5-8

Laboratoire d'anatomie et cytologie pathologiques, de l'hôpital Aristide-Le-Dantec, Dakar, Sénégal.

Laryngeal tuberculosis (LT) is a rare disease. The therapy for LT is easy but the diagnosis remains a challenge for the pathologist and the laryngologist because of the absence of specific signs. The objective was to analyze the epidemiological and pathological profiles of LT cases in Dakar (Senegal) with a view to better understand this pathology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3166/bspe-2018-0010DOI Listing
January 2018

[Specialized food products with modified carbohydrate profile for dietary correction of diet of patients with type 2 diabetes].

Vopr Pitan 2018 13;87(6):76-88. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In recent years, the incidence of diabetes mellitus (DM) in the world is growing steadily. According to the international diabetes Federation (IDF), the number of DM patients in the world in 2015 was 415 million, of them more than 90% - patients with type 2 diabetes. According to forecasts, in 2040 their number will increase to 642 million. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24411/0042-8833-2018-10069DOI Listing
November 2018

[The prospective of using plant polyphenols as functional food ingredients].

Vopr Pitan 2018 13;87(6):57-66. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In this review we briefly discuss the publications dedicated to experimental evaluation of hypoglycemic, hypolipidemic and antioxidant properties of different plant polyphenols. The stages of preclinical studies of their efficacy are presented: in silico studies with molecular docking methods and in vivo studies with the use of genetic and medicamental models of type 2 diabetes. The results of own studies present the substantiation of prospects of using the plant polyphenol extracts as functional food ingredients for diet therapy and treatment of patients with type 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24411/0042-8833-2018-10067DOI Listing
November 2018

[Modern approaches to dietary support for patients with diabetic nephropathy].

Vopr Pitan 2018 13;87(6):6-15. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The article presents modern approaches to dietary support of patients with diabetic nephropathy (DN) characterized by gradual sclerosis of the renal tissue, leading to a loss of filtration and nitrogen excretory function of the kidneys. An analysis of publications of domestic and foreign authors indicates a slowdown in the progression of chronic kidney disease against the background of low-protein diets. However, the role of protein restriction and its qualitative composition in the diet of patients with DN is the subject of comprehensive discussion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24411/0042-8833-2018-10061DOI Listing
November 2018

A Whole-Grain Diet Increases Glucose-Stimulated Insulin Secretion Independent of Gut Hormones in Adults at Risk for Type 2 Diabetes.

Mol Nutr Food Res 2019 Feb 14:e1800967. Epub 2019 Feb 14.

Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Introduction: Few data exist examining the effects of whole grain (WG) versus refined grain (RG) diets on glucose-stimulated insulin secretion (GSIS) and β-cell function.

Methods: In a double-blind crossover randomized controlled trial, 13 sedentary prediabetic adults (37.2±1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mnfr.201800967DOI Listing
February 2019

Therapeutic Options for Neuroendocrine Tumors: A Systematic Review and Network Meta-analysis.

JAMA Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Nuclear Medicine, University Hospital, University of Geneva, Geneva, Switzerland.

Importance: Multiple therapies are currently available for patients with neuroendocrine tumors (NETs), yet many therapies have not been compared head-to-head within randomized clinical trials (RCTs).

Objective: To assess the relative safety and efficacy of therapies for NETs.

Data Sources: PubMed, Embase, the Cochrane Central Register of Controlled Trials, trial registries, meeting abstracts, and reference lists from January 1, 1947, to March 2, 2018, were searched. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2018.6720DOI Listing
February 2019

Classical celiac disease is more frequent with a double dose of HLA-DQB1*02: A systematic review with meta-analysis.

PLoS One 2019 14;14(2):e0212329. Epub 2019 Feb 14.

Division of Gastroenterology, First Department of Medicine, University of Pécs, Medical School, Pécs, Hungary.

Background And Aims: Experimental data suggest that the HLA-DQ2 gene dose has a strong quantitative effect on clinical outcomes and severity of celiac disease (CD). We aimed to conduct a meta-analysis with systematic review to investigate the association between HLA-DQB1*02 gene doses and the characteristics of CD.

Methods: We searched seven medical databases for studies discussing HLA-DQB1 gene dose in CD and various disease characteristics, such as clinical presentation, histology, age at diagnosis, and comorbidities. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212329PLOS
February 2019

Is type of depressive symptoms associated with patient-perceived need for professional psychological care in depressed individuals with diabetes?

PLoS One 2019 14;14(2):e0212304. Epub 2019 Feb 14.

Department of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Aims: The objective of this study is to investigate whether type of depressive symptoms (i.e. cognitive-affective or somatic) is related to a patient-perceived need for professional psychological care in individuals with diabetes. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212304PLOS
February 2019

Serum amyloid A and Janus kinase 2 in a mouse model of diabetic kidney disease.

PLoS One 2019 14;14(2):e0211555. Epub 2019 Feb 14.

Providence Medical Research Center, Providence Health Care, Spokane, Washington, United States of America.

Background: Serum amyloid A (SAA), a potent inflammatory mediator, and Janus kinase 2 (JAK2), an intracellular signaling kinase, are increased by diabetes. The aims were to elucidate: 1) a JAK2-mediated pathway for increased SAA in the kidneys of diabetic mice; 2) a JAK2-SAA pathway for inflammation in podocytes.

Methods: Akita diabetic mice (129S6) with podocyte JAK2 overexpression and angiotensin II infusion (4 weeks) were given a JAK1,2 inhibitor (LY03103801, 3 mg/kg/day orally for the last two weeks). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211555PLOS
February 2019

Trend and projection of mortality rate due to non-communicable diseases in Iran: A modeling study.

PLoS One 2019 14;14(2):e0211622. Epub 2019 Feb 14.

Regional Knowledge Hub, and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Background: Following the epidemiologic and demographic transition, non-communicable disease mortality is the leading cause of death in Iran. Projecting mortality trend can provide valuable tools for policy makers and planners. In this article, we have estimated the trend of non-communicable disease mortality during 2001-2015 and have projected it until 2030 at national and subnational levels in Iran. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211622PLOS
February 2019

The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair.

PLoS Genet 2019 Feb 14;15(2):e1007971. Epub 2019 Feb 14.

Department of Animal Biology, Faculty of Science, University of Málaga, Málaga, Spain.

The Wilms' tumor suppressor gene (Wt1) encodes a zinc finger transcription factor that plays an essential role in the development of kidneys, gonads, spleen, adrenals and heart. Recent findings suggest that WT1 could also be playing physiological roles in adults. Systemic deletion of WT1 in mice provokes a severe deterioration of the exocrine pancreas, with mesothelial disruption, E-cadherin downregulation, disorganization of acinar architecture and accumulation of ascitic transudate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1007971DOI Listing
February 2019

Indications for echocardiography of replacement heart valves: a joint statement from the BHVS and BSE.

Echo Res Pract 2019 Feb 1. Epub 2019 Feb 1.

R Steeds, Cardiology, University Hospital of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Echocardiography plays a vital role in the follow up of patients with replacement heart valves. However, there is considerable variation in international guidelines regarding the recommended time points after implantation at which routine echocardiography should be performed. The purpose of routine echocardiography is to detect early structural valve deterioration in biological valves to improve the timing of redo interventions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERP-18-0079DOI Listing
February 2019

Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study.

Endocr Connect 2019 Feb 1. Epub 2019 Feb 1.

A Maia, INTERNAL MEDICINE, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL, Porto Alegre, 90035-003, Brazil.

Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumours. Several reports have demonstrated that the RET mutation profile may vary according to geographical area. In this study we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EC-18-0506DOI Listing
February 2019

Complex diseases and co-morbidities: polycystic ovary syndrome and type 2 diabetes mellitus.

Endocr Connect 2019 Feb 1. Epub 2019 Feb 1.

H Teede, Monash Centre for Health Research and Implementation, Monash University, Clayton, Australia.

Objective: Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8-13% of women of reproductive age. Read More

View Article

Download full-text PDF

Source
https://ec.bioscientifica.com/view/journals/ec/aop/ec-18-050
Publisher Site
http://dx.doi.org/10.1530/EC-18-0502DOI Listing
February 2019
1 Read

Reference range of fetal myocardial area by three-dimensional ultrasonography and its applicability in fetuses of pre-gestational diabetic women.

J Perinat Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo-SP, Brazil.

Objectives To determine the reference range for the myocardial area in healthy fetuses using three-dimensional (3D) ultrasonography and validate these results in fetuses of pregnant women with pre-gestational diabetes mellitus (DM). Methods This cross-sectional retrospective study included 168 healthy pregnant women between gestational weeks 20 and 33+6 days. The myocardial area was measured using spatio-temporal image correlation (STIC) in the four-chamber view. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/jpm-2018-0342DOI Listing
February 2019

Detection and Control of Unannounced Exercise in the Artificial Pancreas without Additional Physiological Signals.

IEEE J Biomed Health Inform 2019 Feb 11. Epub 2019 Feb 11.

The purpose of this study was to develop an algorithm that detects aerobic exercise and triggers disturbance rejection actions to prevent exercise-induced hypoglycemia. This approach can provide a solution to poor glycemic control during and after aerobic exercise, a major hindrance in the participation of exercise by patients with type 1 diabetes. This novel exercise-induced hypoglycemia reduction algorithm (EHRA) detects exercise using a threshold on a disturbance term, a parameter estimated from an augmented minimal model using an Unscented Kalman Filter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/JBHI.2019.2898558DOI Listing
February 2019

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm.

Circ Res 2019 Feb;124(4):619-630

From the Wallace H. Coulter Department of Biomedical Engineering, Emory University, Georgia Institute of Technology, Atlanta (S.K., H.J.).

Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall and is among the most challenging cardiovascular diseases as without urgent surgical intervention, ruptured AAA has a mortality rate of >80%. Most patients present acutely after aneurysm rupture or dissection from a previously asymptomatic condition and are managed by either surgery or endovascular repair. Patients usually are old and have other concurrent diseases and conditions, such as diabetes mellitus, obesity, and hypercholesterolemia making surgical intervention more difficult. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.118.312438DOI Listing
February 2019

DYSGLYCEMIA-BASED CHRONIC DISEASE: AN AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS POSITION STATEMENT.

Endocr Pract 2018 Nov;24(11):995-1011

The American Association of Clinical Endocrinologists (AACE) has created a dysglycemia-based chronic disease (DBCD) multimorbidity care model consisting of four distinct stages along the insulin resistance-prediabetes-type 2 diabetes (T2D) spectrum that are actionable in a preventive care paradigm to reduce the potential impact of T2D, cardiometabolic risk, and cardiovascular events. The controversy of whether there is value, cost-effectiveness, or clinical benefit of diagnosing and/or managing the prediabetes state is resolved by regarding the problem, not in isolation, but as an intermediate stage in the continuum of a progressive chronic disease with opportunities for multiple concurrent prevention strategies. In this context, stage 1 represents "insulin resistance," stage 2 "prediabetes," stage 3 "type 2 diabetes," and stage 4 "vascular complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4158/PS-2018-0139DOI Listing
November 2018

Type 2 Diabetes Therapies: A STEPS Approach.

Am Fam Physician 2019 Feb;99(4):237-243

United Health Services, Johnson City, NY, USA.

A concise way to evaluate pharmacotherapy options for type 2 diabetes mellitus is to use the five patient-oriented STEPS criteria: safety, tolerability, efficacy, price, and simplicity. The first-line treatment option, metformin, is safe and fairly well-tolerated, has excellent long-term efficacy for patient-oriented outcomes, is moderately priced, and has a simple dosing regimen. However, most patients with type 2 diabetes require more than one medication. Read More

View Article

Download full-text PDF

Source
February 2019

Performance of the adapted Diabetes Complications Severity Index translated to ICD-10.

Am J Manag Care 2019 Feb 1;25(2):e45-e49. Epub 2019 Feb 1.

Institute of General Practice, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Email:

Objectives: To assess the performance of the adapted Diabetes Complications Severity Index (aDCSI) translated to International Classification of Diseases, Tenth Revision (ICD-10) in predicting hospitalizations, mortality, and healthcare-associated costs.

Study Design: Retrospective closed cohort study based on secondary data analysis.

Methods: We translated the aDCSI to ICD-10 and calculated aDCSI scores based on health insurance claims data. Read More

View Article

Download full-text PDF

Source
February 2019

Medication adherence as a measure of the quality of care provided by physicians.

Am J Manag Care 2019 Feb;25(2):78-83

USC Schaeffer Center, VPD Suite 414, Los Angeles, CA 90087. Email:

Objectives: To assess the extent to which medication adherence in congestive heart failure (CHF) and diabetes may serve as a measure of physician-level quality.

Study Design: A retrospective analysis of Medicare data from 2007 to 2009, including parts A (inpatient), B (outpatient), and D (pharmacy).

Methods: For each disease, we assessed the correlation between medication adherence and health outcomes at the physician level. Read More

View Article

Download full-text PDF

Source
February 2019

Soluble fibers improve metabolic syndrome but may cause liver disease and hepatocellular carcinoma.

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, 10032, USA.

Nearly 25% of the world's population is suffering from non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity and type 2 diabetes. NAFLD may progress to the development of non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). With efficient medical therapies lacking, modifications of life style and diet are considered the best options for the prevention and treatment of NAFLD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.30565DOI Listing
February 2019

Hip fracture risk in patients with cirrhosis: does diabetes mellitus matter?

Authors:
Mindie H Nguyen

Hepatology 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Division of Gastroenterology and Hepatology, 750 Welch Road, Suite 210, Palo Alto, California, United States.

In this article, Dr. Lai discusses the risk of hip fractures in persons with cirrhosis and when diabetes is present, the risk for hip fracture is 2.5 times greater (9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.30560DOI Listing
February 2019

IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: An observational study.

Medicine (Baltimore) 2019 Feb;98(7):e14587

Division of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila.

Recently, it has been shown that some well-known pathogenic mediators in rheumatoid arthritis (RA), such as interleukin-1β (IL-1β) and tumor necrosis factor (TNF), could play a pathogenic role in insulin resistance and (IR) and type 2 diabetes (T2D).In this 6-month longitudinal study, we aimed at investigating if the inhibition of IL-1 or TNF is associated with an improvement of IR in RA patients with comorbid T2D and the possible effects on selected serum adipokines. RA patients with comorbid T2D were recruited among those undergoing treatment with anakinra (ANA) or with TNF inhibitor (TNFi). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014587DOI Listing
February 2019

Surveillance of non-muscle invasive bladder cancer using fluorescence in situ hybridization: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Feb;98(7):e14573

Department of Urology, Institute of Urology.

Background: To evaluate the diagnostic effectiveness and predictive value of fluorescence in situ hybridization (FISH) in the surveillance of non-muscle invasive bladder cancer (NMIBC).

Methods: PubMed/Medline, EMBASE, Web of Science, Ovid, Web of Knowledge, and Cochrane Library will be searched for studies related to the topic. The identification, inclusion, and exclusion flowcharts will be conducted according to preferred reporting items for systematic reviews and meta-analysis guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014573DOI Listing
February 2019

Incidence of surgical-site infection following open reduction and internal fixation of a distal femur fracture: An observational case-control study.

Medicine (Baltimore) 2019 Feb;98(7):e14547

Department of Orthopaedic Surgery.

Surgical-site infection (SSI) is a common complication in orthopedic surgery; however, SSI after surgically managed distal femur fractures was not well studied. The aim of this study was to investigate the incidence of SSI and identify some modifiable and nonmodifiable risk factors.The patients' electronic medical records (EMRs) were reviewed to identify those who sustained a distal femur fracture and treated by open reduction and internal fixation (ORIF) between March 2014 and February 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014547DOI Listing
February 2019

Risk of subsequent health disorders among living kidney donors.

Medicine (Baltimore) 2019 Feb;98(7):e14494

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University.

Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens.We comprehensively investigated the risk of medical disorders after kidney donation in living KDs using a maximum follow-up of 13 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014494DOI Listing
February 2019

Increased risk of neurodegenerative dementia in women with migraines: A nested case-control study using a national sample cohort.

Medicine (Baltimore) 2019 Feb;98(7):e14467

Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.

The present study aimed to evaluate the association between migraines and dementia.Data were collected from 11,438 dementia participants who were 1:4 matched by age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 45,752 controls from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Dementia was diagnosed using the International Classification of Disease-10 (ICD-10) codes (G30 or F00). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014467DOI Listing
February 2019

The triad of diabetes ketoacidosis, hypertriglyceridemia and acute pancreatitis. How does it affect mortality and morbidity?: A 10-year analysis of the National Inpatient Sample.

Medicine (Baltimore) 2019 Feb;98(7):e14378

Gastroenterology and Hepatology Department, Digestive Disease Institute.

The triad of acute pancreatitis (AP) coexisting with diabetes ketoacidosis (DKA) and hypertriglyceridemia (HTG) has been reported, but no impact on mortality has been found to date. We aim to assess if patients with this triad are at a higher inpatient mortality compared to patients with acute pancreatitis only.Retrospective cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014378DOI Listing
February 2019
1 Read

Metabolic Monitoring of Child and Adolescent Patients on Atypical Antipsychotics by Psychiatrists and Primary Care Providers.

Am J Ther 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychiatry, McLeod Medical Center, Florence, SC.

Background: Antipsychotic drug use in children has doubled from 2001 to 2007 with concomitant increase in obesity. Second-generation antipsychotic (SGA) medication use is associated with weight gain, metabolic derangements, and blood sugar and lipid abnormalities in children. The American Psychiatric Association and the American Diabetes Association have recommended metabolic monitoring guidelines for patients using SGA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MJT.0000000000000853DOI Listing
February 2019

Discovering the Type 2 Diabetes in Electronic Health Records using the Sparse Balanced Support Vector Machine.

IEEE J Biomed Health Inform 2019 Feb 13. Epub 2019 Feb 13.

The diagnosis of Type 2 Diabetes (T2D) at an early stage has a key role for an adequate T2D integrated management system and patient's follow-up. Recent years have witnessed an increasing amount of available Electronic Health Record (EHR) data and Machine Learning (ML) techniques have been considerably evolving. However, managing and modeling this amount of information may lead to several challenges such as overfitting, model interpretability and computational cost. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/JBHI.2019.2899218DOI Listing
February 2019

RORB and RORC associate with human islet dysfunction and inhibit insulin secretion in INS-1 cells.

Islets 2019 Feb 14:1-11. Epub 2019 Feb 14.

b Department of Clinical Science, Division of Islet Cell Physiology , Lund University , Malmö , Sweden.

Little is known about the expression and function of Retinoic acid-related orphan receptors (RORA, B, and C) in pancreatic β cells. Here in, we utilized cDNA microarray and RNA sequencing approaches to investigate the expression pattern of ROR receptors in normal and diabetic human pancreatic islets. Possible correlations between RORs expression and HbA levels as well as insulin secretory capacity in isolated human islets were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/19382014.2019.1566684DOI Listing
February 2019

Evolution of Transluminal Necrosectomy for Acute Pancreatitis to Stent in Stent Therapy: Step-Up Approach Leads to Low Mortality and Morbidity Rates in 302 Consecutive Cases of Acute Pancreatitis.

J Laparoendosc Adv Surg Tech A 2019 Feb 14. Epub 2019 Feb 14.

1 Department of General and Visceral Surgery, Congregation Hospital (Sisters of Charity), Linz, Austria.

Background: The step-up approach, using either flexible endoscopy or a minimal invasive retroperitoneal access, has reduced mortality and morbidity in patients with acute pancreatitis. The use of fully covered self-expanding metal stents (FCSEMS) or lumen apposing metal stents (LAMS) facilitates endoscopic necrosectomy and drainage of walled-off necrosis (WON). The aim of our analysis was to investigate the 30/90/365-day mortality and morbidity rates of the subtypes of the revised Atlanta classification for acute pancreatitis. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/lap.2018.0768
Publisher Site
http://dx.doi.org/10.1089/lap.2018.0768DOI Listing
February 2019
1 Read

Impact of Human Factors Testing on Medical Device Design: Validation of an Automated CGM Sensor Applicator.

J Diabetes Sci Technol 2019 Feb 14:1932296819831071. Epub 2019 Feb 14.

4 CGParkin Communications, Inc, Henderson, NV, USA.

Improving user engagement with continuous glucose monitoring (CGM) is considered a major requirement for achieving optimal treatment efficacy. Human factors testing is needed to ensure that CGM product designs and requisite training simplify the user experience and enhance usability and patient safety. Dexcom, Inc, recently introduced a novel, "one-button" automatic sensor applicator (ASA) for use with the Dexcom G6 (rtCGM) system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1932296819831071DOI Listing
February 2019

Gamification and Behavior Change Techniques in Diabetes Self-Management Apps.

J Diabetes Sci Technol 2019 Feb 14:1932296818822998. Epub 2019 Feb 14.

1 Health Psychology, Johannes Gutenberg University Mainz, Mainz, Germany.

Background:: Diabetes management apps may have positive effects on diabetes self-management. It remains unclear, however, which app features are particularly effective and encourage sustained app usage. Behavior change techniques (BCTs) and gamification are promising approaches to improve user engagement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1932296818822998DOI Listing
February 2019

Molecular and Materials Engineering for Delivery of Peptide Drugs to Treat Type 2 Diabetes.

Adv Healthc Mater 2019 Feb 14:e1801509. Epub 2019 Feb 14.

Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.

Type 2 diabetes is exploding globally. Despite numerous treatment options, nearly half of type 2 diabetics are unsuccessful at properly managing the disease, primarily due to a lack of patient compliance, driven by adverse side effects as well as complicated and frequent dosing schedules. Improving the delivery of type 2 diabetes drugs has the potential to increase patient compliance and thus, greatly enhance health outcomes and quality of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.201801509DOI Listing
February 2019

Body Weight and eGFR during Dulaglutide Treatment in Type 2 Diabetes and Moderate-to-Severe Chronic Kidney Disease (AWARD-7).

Diabetes Obes Metab 2019 Feb 14. Epub 2019 Feb 14.

Eli Lilly and Company, Indianapolis, IN, USA.

In patients with T2D and moderate-to-severe CKD, dulaglutide treatment led to body weight (BW) loss and lesser eGFR decline compared to insulin glargine. Since BW may affect muscle mass, creatinine-based eGFR can be altered independent of kidney function. Cystatin C-based eGFR is not affected by muscle mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13668DOI Listing
February 2019

Uric acid and the cardio-renal effects of SGLT2 inhibitors.

Diabetes Obes Metab 2019 Feb 14. Epub 2019 Feb 14.

School of Life and Health Sciences, Aston University, Birmingham, UK.

Sodium/glucose co-transporter-2 (SGLT2) inhibitors, which lower blood glucose by increasing renal glucose elimination have been shown to reduce the risk of adverse cardiovascular (CV) and renal events in type 2 diabetes. This has been ascribed in part to haemodynamic changes, body weight reduction and several possible effects on myocardial, endothelial and tubulo-glomerular functions as well as reduced glucotoxicity. This review evaluates evidence that an effect of SGLT2 inhibitors to lower uric acid may also contribute to reduced cardio-renal risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13670DOI Listing
February 2019

FDA guidance on cardiovascular risk of antidiabetic therapies: one decade later.

Diabetes Obes Metab 2019 Feb 14. Epub 2019 Feb 14.

Life and Health Sciences, Aston University, Birmingham, UK.

The 2008 FDA guidance for industry on cardiovascular (CV) risk of new antidiabetic therapies arose from a history of CV safety concerns brought to a head by findings with rosiglitazone and the ACCORD trial of intensive glycaemic control. This article is protected by copyright. All rights reserved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13669DOI Listing
February 2019

Lens autofluorescence ratio as a noninvasive marker of peripheral diabetic neuropathy.

Pol Arch Intern Med 2019 Feb 14. Epub 2019 Feb 14.

INTRODUCTION Diabetes and its complications are a significant cause of morbidity and mortality. Advanced glycation endproducts (AGEs) play a major role in the pathogenesis of  diabetes complications. OBJECTIVES To investigate the possible uses of a biomicroscope (ClearPath DS-120) that shows age-adjusted lens fluorescence ratios (LFRs) for the diagnosis of diabetic peripheral neuropathy (DPN). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20452/pamw.4449DOI Listing
February 2019
  • Page 1 of 13149