665,856 results match your criteria Diabetes & Vascular Disease Research[Journal]


Characterization of Initial Stages of Diabetic Macular Edema.

Ophthalmic Res 2019 Apr 23:1-8. Epub 2019 Apr 23.

AIBILI, Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal,

Purpose: This study is aimed at characterizing the type of retinal edema in the initial stages of retinopathy in type 2 diabetes.

Methods: In this retrospective cross-sectional study, spectral domain optical coherence tomography (OCT) layer by layer analysis of the retina in association with OCT-Leakage, an algorithm to detect sites of low optical reflectivity, were used to examine eyes with minimal, mild, and moderate diabetic retinopathy (DR).

Results: A total of 142 eyes from 142 patients (28% women) aged 52-88 years were imaged. Read More

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http://dx.doi.org/10.1159/000499117DOI Listing

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation.

Ann Nutr Metab 2019 Apr 23;74(4):313-321. Epub 2019 Apr 23.

Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, China,

Background: Exercise therapy plays an important role in the prevention and treatment of type 2 diabetes (T2DM). The mechanism of exercise therapy in the improvement of glycolipid metabolism of T2DM is very complex and not completely clear.

Summary: Exercise training improves the whole body metabolic health in patients with T2DM, leading to an increase in glycolipid uptake and utilization, improved insulin sensitivity, optimized body mass index, and modulated DNA methylation, etc. Read More

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http://dx.doi.org/10.1159/000500110DOI Listing

Consumption of Sugar-Sweetened Beverages in Paediatric Age: A Position Paper of the European Academy of Paediatrics and the European Childhood Obesity Group.

Ann Nutr Metab 2019 Apr 23;74(4):296-302. Epub 2019 Apr 23.

Medical Faculty, University of Rzeszów, Rzeszów, Poland.

Background: Health risks associated with the high consumption of sugar-sweetened beverages (SSBs) include overweight or obesity and their complications such as diabetes, as well as oral and dental decay, among others.

Aim: The aim of the present statement is to inform health care professionals, parents, care-givers, teachers and school head teachers, stakeholders and governing bodies about the risks associated with drinking SSBs in infants, children and adolescents.

Methods: We searched PubMed and the Cochrane databases for English language studies published from 2010 through October 1, 2018, for randomized clinical trials, meta-analyses, systematic reviews and observational studies (search terms are reported in eAppendix in the Supplement). Read More

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http://dx.doi.org/10.1159/000499828DOI Listing

Effect of Circadian Rhythm on Metabolic Processes and the Regulation of Energy Balance.

Ann Nutr Metab 2019 Apr 23;74(4):322-330. Epub 2019 Apr 23.

Faculty of Health Sciences, Department of Nutrition and Dietetic, Gazi University, Ankara, Turkey,

Background: The circadian timing system or circadian clock plays a crucial role in many biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular health, glucose homeostasis, and body temperature regulation. Energy balance is also one of the most important cornerstones of metabolic processes, whereas energy imbalance is associated with many diseases (i.e. Read More

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https://www.karger.com/Article/FullText/500071
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http://dx.doi.org/10.1159/000500071DOI Listing
April 2019
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Patient-Reported Experiences in Discussing Prescribed Medications with a Health Care Provider: Evidence for Racial/Ethnic Disparities in a Large Health Care Delivery System.

Popul Health Manag 2019 Apr 23. Epub 2019 Apr 23.

1 Palo Alto Medical Foundation Research Institute, Sutter Health, Palo Alto, California.

The objective was to understand patient-reported experiences in communicating with a health care provider about prescribed medications in a health care setting serving diverse racial/ethnic groups. Adult patients who completed a patient-experience survey and received a prescription for a hypertension, hyperlipidemia, or diabetes medication at the surveyed encounter were studied (N = 19,006). Data were collected in a large mixed-payer outpatient health care system in northern California between 2011 and 2014. Read More

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https://www.liebertpub.com/doi/10.1089/pop.2018.0206
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http://dx.doi.org/10.1089/pop.2018.0206DOI Listing
April 2019
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Anticholinergic Burden and Dry Mouth in Middle-Aged People.

JDR Clin Trans Res 2019 Apr 23:2380084419844511. Epub 2019 Apr 23.

1 Periodontology and Geriatric Dentistry, Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland.

Introduction: Anticholinergic burden refers to the cumulative effect of taking 1 or more drugs with anticholinergic properties. At the moment, little is known about the association between the anticholinergic burden and dry mouth.

Objectives: The objective of this article was to study, whether an anticholinergic burden is associated with dry mouth among middle-aged people. Read More

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http://dx.doi.org/10.1177/2380084419844511DOI Listing

In New-Onset Diabetes Mellitus, Metformin Reduces Fat Accumulation in the Liver, But Not in the Pancreas or Pericardium.

Metab Syndr Relat Disord 2019 Apr 23. Epub 2019 Apr 23.

1 First Department of Medicine, University of Szeged, Szeged, Hungary.

Nonalcoholic fatty pancreas and liver disease (NAFPD and NAFLD) and pericardial adipose tissue (PAT) are often associated with type 2 diabetes mellitus (T2DM). Our aim was to evaluate the incidence rate of NAFLD and NAFPD, PAT size, and the effect of metformin treatment on NAFLD, NAFPD, and PAT in new-onset T2DM (NODM). Seventeen patients with NODM and 10 subjects used as a control group were involved in the study. Read More

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http://dx.doi.org/10.1089/met.2018.0086DOI Listing

Mathematical predictions of oxygen availability in micro- and macro-encapsulated human and porcine pancreatic islets.

J Biomed Mater Res B Appl Biomater 2019 Apr 23. Epub 2019 Apr 23.

Department of Surgery, University of California, Irvine, Orange, California.

Optimal function of immunoisolated islets requires adequate supply of oxygen to metabolically active insulin producing beta-cells. Using mathematical modeling, we investigated the influence of the pO on islet insulin secretory capacity and evaluated conditions that could lead to the development of tissue anoxia, modeled for a 300 μm islet in a 500 μm microcapsule or a 500 μm planar, slab-shaped macrocapsule. The pO was used to assess the part of islets that contributed to insulin secretion. Read More

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http://dx.doi.org/10.1002/jbm.b.34393DOI Listing

Glucokinase and the potential of glucokinase activation in type 2 diabetes.

J Diabetes 2019 Apr 23. Epub 2019 Apr 23.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

No abstract is available for this article. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/1753-0407.12937DOI Listing

Hypertension Contributes to Neuropathy in Patients with Type 1 Diabetes.

Am J Hypertens 2019 Apr 23. Epub 2019 Apr 23.

Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.

Background: Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and amputation. There are currently no disease modifying therapies for DPN. The aim of this study was to determine if hypertension contributes to DPN in patients with T1DM. Read More

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http://dx.doi.org/10.1093/ajh/hpz058DOI Listing

Comparison of the microbiome, metabolome, and lipidome of obese and non-obese horses.

PLoS One 2019 23;14(4):e0215918. Epub 2019 Apr 23.

Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, United States of America.

Metabolic diseases such as obesity and type 2 diabetes in humans have been linked to alterations in the gastrointestinal microbiota and metabolome. Knowledge of these associations has improved our understanding of the pathophysiology of these diseases and guided development of diagnostic biomarkers and therapeutic interventions. The cellular and molecular pathophysiology of equine metabolic syndrome (EMS) and obesity in horses, however, remain ill-defined. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215918PLOS

The association between neck adiposity and long-term outcome.

PLoS One 2019 23;14(4):e0215538. Epub 2019 Apr 23.

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Anthropometric indices of obesity (e.g. body mass index, waist circumference and neck circumference) are associated with poor long-term cardiovascular outcome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215538PLOS

Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis.

PLoS One 2019 23;14(4):e0215840. Epub 2019 Apr 23.

Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

Scope: Studies have demonstrated inconsistent effects of curcumin on glycemic outcomes and lipid parameters in patients with prediabetes and type 2 diabetes mellitus (T2DM). This study aimed to assess the effect of curcumin on glycemic control and lipid profile in prediabetes and T2DM.

Methods And Results: A systematic search of randomized controlled trials (RCTs) was conducted from inception to June 2018 in electronic sources including AMED, ANZCTR, BioMed Central, CENTRAL, CINAHL, ClinicalTrials. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215840PLOS

Systematic review on barriers and enablers for access to diabetic retinopathy screening services in different income settings.

PLoS One 2019 23;14(4):e0198979. Epub 2019 Apr 23.

Department of Eye Health and Disability, Indian Institute of Public Health, Public Health Foundation of India, Hyderabad, Telangana, India.

Background: Diabetic retinopathy (DR) can lead to visual impairment and blindness if not detected and treated in time. Knowing the barriers/enablers in advance in contrasting different country income settings may accelerate development of a successful DR screening (DRS) program. This would be especially applicable in the low-income settings with the rising prevalence of DR. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198979PLOS

Transcriptional Regulation of Early Growth Response Gene-1 (EGR1) is Associated with Progression of Nonalcoholic Fatty Liver Disease (NAFLD) in Patients with Insulin Resistance.

Med Sci Monit 2019 Apr 23;25:2293-3004. Epub 2019 Apr 23.

Department of Minimally Invasive Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).

BACKGROUND The occurrence of nonalcoholic fatty liver disease (NAFLD) is closely related to type 2 diabetes, especially in patients with insulin resistance. The purpose of this research was to elucidate the major genes and transcriptional regulation of insulin resistance in the progression of NAFLD. MATERIAL AND METHODS We downloaded the gene expression matrix of GSE89632 from Gene Expression Omnibus. Read More

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http://dx.doi.org/10.12659/MSM.914044DOI Listing

Opening Pandora's Box - Presumed ST Segment Elevation Myocardial Infarction with Symptomatic Ventricular Tachycardia is Cured by Resection of a Huge Left Ventricular Aneurysm.

Heart Surg Forum 2019 Apr 16;22(2):E170-E171. Epub 2019 Apr 16.

Cardioangiologisches Centrum Bethanien (CCB), Frankfurt am Main, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Frankfurt am Main, Germany.

A 76-year-old male patient with history of hypertension, type 2 diabetes, and smoking was admitted to the emergency department with chest pain. The patient reported severe and sudden chest pain accompanied by cold sweating, dizziness, and palpitations. Read More

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http://dx.doi.org/10.1532/hsf.2287DOI Listing

Into the deep blue sea: A review of the safety of recreational diving in people with diabetes mellitus.

Eur J Sport Sci 2019 Apr 23:1-16. Epub 2019 Apr 23.

a Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School , Aristotle University of Thessaloniki, AHEPA University Hospital , Thessaloniki , Greece.

People with diabetes, particularly those being insulin treated, have been for many years considered ineligible for diving, because of the high risk of adverse events. Blood glucose levels tend to decline during diving, probably because of changes in insulin requirements and resistance, due to increased physical activity and effects of hyperbaric environment on glucose tolerance. Strict adherence to safety protocols, in conjunction with optimal physical status, lack of diabetic complications (especially impaired awareness of hypoglycaemia) and satisfactory baseline glycaemic control, seem to minimise the risk of complications during diving. Read More

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https://www.tandfonline.com/doi/full/10.1080/17461391.2019.1
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http://dx.doi.org/10.1080/17461391.2019.1606286DOI Listing
April 2019
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FATTY KIDNEY DISEASE: A NEW RENAL AND ENDOCRINE CLINICAL ENTITY? DESCRIBING THE ROLE OF THE KIDNEY IN OBESITY, METABOLIC SYNDROME AND TYPE 2 DIABETES.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

Both authors have no conflicts of interest for this manuscript and contributed equally to its writing.

Objective: To determine whether fatty kidney disease deserves be designated as a distinct clinical entity similar to fatty liver disease.

Methods: Analysis and interpretation of the literature in a novel conceptual framework.

Results: The kidney contributes to hyperglycemia, hypertension, inflammatory cytokines, and thus to diabetes and metabolic syndrome. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0568
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http://dx.doi.org/10.4158/EP-2018-0568DOI Listing

EXTERNAL VALIDATION OF A PREDICTIVE MODEL FOR ACUTE PANCREATITIS RISK IN PATIENTS WITH SEVERE HYPERTRIGLYCERIDEMIA.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1Division of Endocrinology and Diabetes, John H. Stroger, Jr. Hospital of Cook County, and Rush University Medical Center, Chicago, IL.

We previously developed a predictive model to assess the risk of developing acute pancreatitis (AP) in patients with severe hypertriglyceridemia (HTG). In this study, we aimed to externally validate this model. The validation cohort included cross-sectional data between 2013 and 2017. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0599
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http://dx.doi.org/10.4158/EP-2018-0599DOI Listing
April 2019
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HEALTH-RELATED QUALITY OF LIFE IN CHILDREN AND ADOLESCENTS WITH NON-CLASSIC CONGENITAL ADRENAL HYPERPLASIA.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1 Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center.

Non-classic congenital adrenal hyperplasia (NCCAH) is a late-onset milder form of congenital adrenal hyperplasia (CAH) which differs dramatically from the classic form. Health-related quality of life (HRQOL) in pediatric patients with the sole diagnosis of NCCAH has not been determined, in this study we aimed to determine whether HRQOL is compromised in comparison to the general population. : Single-center, cross-sectional, case-control study. Read More

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http://dx.doi.org/10.4158/EP-2018-0617DOI Listing

ASSOCIATIONS BETWEEN VITAMIN D AND MICROVASCULAR COMPLICATIONS IN MIDDLE-AGED AND ELDERLY DIABETIC PATIENTS.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The objective of the cross-sectional study was to investigate the association of serum 25-hydroxyvitamin D [25(OH)D] levels with estimated glomerular filtration rate (eGFR), albuminuria/creatinine ratio (ACR) and the prevalence of diabetic retinopathy (DR) in Chinese diabetic adults. 4,767 diabetic participants were enrolled from seven communities in Shanghai, China in 2018. Participants underwent several checkups, which included the measurement of anthropometric parameters, blood pressure, glucose, lipid profiles, 25(OH)D and ACR. Read More

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http://dx.doi.org/10.4158/EP-2019-0015DOI Listing

The autonomic nervous system regulates pancreatic beta-cell proliferation in adult male rats.

Am J Physiol Endocrinol Metab 2019 Apr 23. Epub 2019 Apr 23.

Montreal Diabetes Research Center, CRCHUM, and Department of Medicine, University of Montreal, QC, Canada, Canada.

The pancreatic beta-cell responds to changes in the nutrient environment to maintain glucose homeostasis by adapting its function and mass. Nutrients can act directly on the beta-cell and also indirectly through the brain via autonomic nerves innervating islets. Despite the importance of the brain-islet axis in insulin secretion, relatively little is known regarding its involvement in beta-cell proliferation. Read More

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http://dx.doi.org/10.1152/ajpendo.00385.2018DOI Listing

Clinical impact of testing for mutations and microRNAs in thyroid nodules.

Diagn Cytopathol 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiology, University of Southern California, Keck School of Medicine, Los Angeles, California.

Background: We report results of a multicenter clinical experience study examining the likelihood of patients with indeterminate thyroid nodules to undergo surgery or have malignant outcome based on multiplatform combination mutation and microRNA testing (MPT).

Methods: MPT assessed mutations in BRAF, HRAS, KRAS, NRAS, and PIK3CA genes, PAX8/PPARγ, RET/PTC1, and RET/PTC3 gene rearrangements, and the expression of 10 microRNAs. Baseline clinical information at the time of MPT and clinical follow-up records were reviewed for 337 patients, of which 80% had negative MPT results. Read More

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http://dx.doi.org/10.1002/dc.24190DOI Listing

Altered Glycemic Control Associated With Polymorphisms in the SLC22A1 (OCT1) Gene in a Mexican Population With Type 2 Diabetes Mellitus Treated With Metformin: A Cohort Study.

J Clin Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades "Bernardo Sepúlveda," Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

The organic cation transporters OCT1 and OCT2 and the multidrug and toxin extrusion transporter MATE1, encoded by the SLC22A1, SLC22A2, and SLC47A1 genes, respectively, are responsible for the absorption of metformin in enterocytes, hepatocytes, and kidney cells. The aim of this study was to evaluate whether genetic variations in the SLC22A1, SLC22A2, and SLC47A1 genes could be associated with an altered response to metformin in patients with type 2 diabetes mellitus. A cohort study was conducted in 308 individuals with a diagnosis of type 2 diabetes mellitus of less than 3 years and who had metformin monotherapy. Read More

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http://dx.doi.org/10.1002/jcph.1425DOI Listing

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High-Fat Diet and Streptozotocin-Induced Type II Diabetes Nephropathy and Apoptosis.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Sciences, School of Allied Health Sciences, Walailak Univ., Nakhon Si Thammarat, 80161, Thailand.

Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)-induced T2D nephropathy of albino mice. Read More

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http://dx.doi.org/10.1111/1750-3841.14511DOI Listing

A randomized controlled trial of a wearable technology-based intervention for increasing moderate to vigorous physical activity and reducing sedentary behavior in breast cancer survivors: The ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: The benefits of an active lifestyle after a breast cancer diagnosis are well recognized, but the majority of survivors are insufficiently active. The ACTIVATE Trial examined the efficacy of an intervention (use of the Garmin Vivofit 2 activity monitor coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions) to increase moderate to vigorous physical activity (MVPA) and reduce sedentary behavior in breast cancer survivors.

Methods: This randomized controlled trial recruited 83 inactive, postmenopausal women diagnosed with stage I-III breast cancer who had completed primary treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32143
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http://dx.doi.org/10.1002/cncr.32143DOI Listing
April 2019
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Maintenance of physical activity and sedentary behavior change, and physical activity and sedentary behavior change after an abridged intervention: Secondary outcomes from the ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: This brief report examines the maintenance of moderate to vigorous physical activity (MVPA) and sedentary behavior changes approximately 12 weeks after the delivery of the ACTIVATE Trial primary intervention (use of the Garmin Vivofit 2 activity tracker coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions). We also examine the efficacy of an abridged intervention (use of the Garmin Vivofit 2 only) in the waitlist control group.

Methods: A pre-post design was employed to examine the secondary aims of the ACTIVATE Trial (n = 80; mean age = 62 years). Read More

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http://dx.doi.org/10.1002/cncr.32142DOI Listing

Lycopene Ameliorated Oxidative Stress and Inflammation in Type 2 Diabetic Rats.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Dept. of Nutrition, School of Public Health, Sun Yat-Sen Univ., No.74, 2nd Yat-Sen Road, Guangzhou, Guangdong, 510080, China.

We aim to study the antioxidative and anti-inflammatory effects of lycopene on type 2 diabetes mellitus (T2DM) rats, anticipating a complementary strategy for the prevention of long-term complications of T2DM. In this study, rats with streptozotocin-induced diabetes were divided into four groups, receiving a 10-week lycopene intervention: DM, DM + low dose of lycopene (L), DM + medium dose of lycopene (M), and DM + high dose of lycopene (H) group with 0, 5, 10, and 15 mg/kg BW lycopene, respectively. At the end of intervention, fasted blood glucose (FBG) level, oxidative stress indicators, including glycosylated hemoglobin (GHb), glycosylated low-density lipoprotein, oxidized low-density lipoprotein (ox-LDL). Read More

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http://dx.doi.org/10.1111/1750-3841.14505DOI Listing

Hospital nurse-staffing models and patient- and staff-related outcomes.

Cochrane Database Syst Rev 2019 Apr 23;4:CD007019. Epub 2019 Apr 23.

Faculty of Science and Health, Dublin City University, Collins Avenue, Glasnevin, Dublin, Ireland, Dublin 9.

Background: Nurses comprise the largest component of the health workforce worldwide and numerous models of workforce allocation and profile have been implemented. These include changes in skill mix, grade mix or qualification mix, staff-allocation models, staffing levels, nursing shifts, or nurses' work patterns. This is the first update of our review published in 2011. Read More

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http://dx.doi.org/10.1002/14651858.CD007019.pub3DOI Listing

Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Glucagon, a hormone released from pancreatic alpha-cells, plays a key role in maintaining proper glucose homeostasis and has been implicated in the pathophysiology of diabetes. In vitro studies suggest that intra-islet glucagon can modulate the function of pancreatic beta-cells. However, because of the lack of suitable experimental tools, the in vivo physiological role of this intra-islet cross-talk has remained elusive. Read More

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http://insight.jci.org/articles/view/127994
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http://dx.doi.org/10.1172/jci.insight.127994DOI Listing

A Noninvasive, Economical, and Instant-Result Method to Diagnose and Monitor Type 2 Diabetes Using Pulse Wave: Case-Control Study.

JMIR Mhealth Uhealth 2019 Apr 23;7(4):e11959. Epub 2019 Apr 23.

Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of Traditional Chinese Medicine Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: We should pay more attention to the long-term monitoring and early warning of type 2 diabetes and its complications. The traditional blood glucose tests are traumatic and cannot effectively monitor the development of diabetic complications. The development of mobile health is changing rapidly. Read More

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http://dx.doi.org/10.2196/11959DOI Listing

Diabetes and Outcomes following Guided De-Escalation of Antiplatelet Treatment in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: A Prespecified Analysis from the Randomized TROPICAL-ACS Trial.

EuroIntervention 2019 Apr 23. Epub 2019 Apr 23.

Ludwig-Maximilians University, Department of Cardiology, Munich, Germany.

Aims: A guided de-escalation of P2Y12 inhibitor treatment is considered as an alternative treatment strategy in ACS patients undergoing PCI. However, the safety and efficacy of this strategy may differ in diabetic vs. non-diabetic patients. Read More

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http://dx.doi.org/10.4244/EIJ-D-18-01077DOI Listing

Assessment of complications following urinary diversion for benign indications.

Can J Urol 2019 Apr;26(2):9720-9725

Department of Urology, University of Virginia, Charlottesville, Virginia, USA.

Introduction: To evaluate complications following urinary diversion for non-malignant conditions.

Materials And Methods: We performed a retrospective review of patients undergoing urinary diversion for benign indications between 2000 and 2017. Data collected including patient demographic and clinical characteristics, surgical characteristics, and complications. Read More

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The Effects of Choline and Magnesium Co-Supplementation on Metabolic Parameters, Inflammation, and Endothelial Dysfunction in Patients With Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial.

J Am Coll Nutr 2019 Apr 23:1-8. Epub 2019 Apr 23.

c Nutrition Research Center, School of Nutrition and Food Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.

Objective: To our knowledge, no study has investigated the effects of choline and magnesium co-supplementation on metabolic parameters, inflammation, and endothelial dysfunction in patients with type 2 diabetes mellitus (T2DM). The aim of this study was investigation of the effects of the choline and magnesium co-supplementation on metabolic parameters, inflammation, and endothelial dysfunction in patients with T2DM.

Methods: A randomized double-blind placebo-controlled parallel clinical trial was carried out among 96 diabetic patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/07315724.2019.1
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http://dx.doi.org/10.1080/07315724.2019.1599745DOI Listing
April 2019
1 Read

Validating the Sedentary Sphere method in children: Does wrist or accelerometer brand matter?

J Sports Sci 2019 Apr 23:1-9. Epub 2019 Apr 23.

a Physical Activity Exchange, Research Institute of Sport and Exercise Sciences , Liverpool John Moores University , Liverpool , UK.

This study aimed to validate the Sedentary Sphere posture classification method from wrist-worn accelerometers in children. Twenty-seven 9-10-year-old children wore ActiGraph GT9X (AG) and GENEActiv (GA) accelerometers on both wrists, and activPAL on the thigh while completing prescribed activities: five sedentary activities, standing with a phone, walking (criterion for all 7: observation) and 10-min free-living play (criterion: activPAL). In an independent sample, 21 children wore AG and GA accelerometers on the non-dominant wrist and activPAL for two days of free-living. Read More

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https://www.tandfonline.com/doi/full/10.1080/02640414.2019.1
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http://dx.doi.org/10.1080/02640414.2019.1605647DOI Listing
April 2019
1 Read

Study of Mutation from DNA to Biological Evolution.

Int J Radiat Biol 2019 Apr 23:1-42. Epub 2019 Apr 23.

a Research Center for Nuclear Physics, Osaka University , Japan.

Purpose: This is a paper based on a talk given in the BER2018 conference by M. Bando. We first emphasize the importance of collaborations among scientists in various fields for the low dose/dose-rate effects on biological body. Read More

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http://dx.doi.org/10.1080/09553002.2019.1606957DOI Listing

Increased risk of diabetes mellitus five years after an episode of Staphylococcus aureus bacteraemia.

Infect Dis (Lond) 2019 Apr 23:1-7. Epub 2019 Apr 23.

a Department of Infectious Diseases , Hvidovre Hospital, University of Copenhagen , Hvidovre , Denmark.

Background: Diabetes mellitus is a risk factor for infection with Staphylococcus aureus, but it is unclear whether S. aureus infection is a prediabetic condition.

Methods: Nationwide population-based matched cohort study. Read More

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http://dx.doi.org/10.1080/23744235.2019.1602284DOI Listing

Synthesis of the N-methyl derivatives of 2-aminothiazol-4(5H)-one and their interactions with 11βHSD1 - molecular modeling and in vitro studies.

Chem Biodivers 2019 Apr 23. Epub 2019 Apr 23.

Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, Poland, POLAND.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an enzyme that affects the body's cortisol levels. The inhibition of its activity can be used in the treatment of Cushing's syndrome, metabolic syndrome and type 2 diabetes. In this study, we synthesized new derivatives of 2-(methylamino)thiazol-4(5H)-one and tested their activity towards inhibition of 11β-HSD1 and its isoform - 11β-HSD2. Read More

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http://dx.doi.org/10.1002/cbdv.201900065DOI Listing

Inverse association between physical activity and blood glucose is independent of sex, menopause status, and first-degree family history of diabetes.

J Diabetes Investig 2019 Apr 23. Epub 2019 Apr 23.

Department of Endocrine and Metabolic Diseases, the First Affiliated Hospital of Wenzhou Medical University, Ouhai District, Wenzhou, 325000, Zhejiang Province, China.

Aims: Exercise training is a recognized strategy central to the prevention, treatment and management of diabetes and prediabetes. The present study was to investigate the association between physical activity and blood glucose, as well as the influence of sex, menopause status, and family history of diabetes.

Materials And Methods: Participants with normal weight were selected from REACTION study, and divided into inactive (moderate-to-vigorous-intensity physical activity [MVPA] < 30 min/week), low-degree (MVPA ≥ 30 and ≤ 420 min/week), and high-degree (MVPA > 420 min/week) active groups. Read More

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http://dx.doi.org/10.1111/jdi.13062DOI Listing

Diabetes: Is there a future for Pharmacogenomics guided treatment?

Authors:
Ewan R Pearson

Clin Pharmacol Ther 2019 Apr 23. Epub 2019 Apr 23.

Division of Population Health & Genomics, School of Medicine, University of Dundee, DD1 9SY.

Diabetes is a disease defined on the basis of hyperglycaemia. There are monogenic forms of diabetes where defining the genetic cause has a dramatic impact on treatment - with patients being able to transition from insulin to sulphonylureas. However, the majority of diabetes is type 2 diabetes. Read More

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http://dx.doi.org/10.1002/cpt.1484DOI Listing

Noncoding Variations in the Gene Encoding Ceramide Synthase 6 are Associated with Type 2 Diabetes in a Large Indigenous Australian Pedigree.

Twin Res Hum Genet 2019 Apr 23:1-9. Epub 2019 Apr 23.

Diabetes Research Laboratories, School of Clinical Medicine Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine,University of Queensland,Brisbane,Queensland,Australia.

Type 2 diabetes (T2D) is a chronic disease that disproportionately affects Indigenous Australians. We have previously reported the localization of a novel T2D locus by linkage analysis to chromosome 2q24 in a large admixed Indigenous Australian pedigree (Busfield et al. (2002). Read More

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http://dx.doi.org/10.1017/thg.2019.13DOI Listing

Reduced medical spending associated with increased use of a remote diabetes management program and lower mean blood glucose values.

J Med Econ 2019 Apr 23. Epub 2019 Apr 23.

d Eli Lilly and Company , Indianapolis , IN , USA.

Aims: Many new mobile technologies are available to assist people in managing chronic conditions, but data on the association between the use of these technologies and medical spending remains limited. As the available digital technology offerings to aid in diabetes management increase, it is important to understand their impact on medical spending. The aim of this study was to investigate the financial impact of a remote digital diabetes management program using medical claims and real-time blood glucose data. Read More

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http://dx.doi.org/10.1080/13696998.2019.1609483DOI Listing

Exploring patient perspectives of prediabetes and diabetes severity: a qualitative study.

Psychol Health 2019 Apr 23:1-14. Epub 2019 Apr 23.

e Family Medicine , Uniformed Services University of the Health Sciences , Bethesda , MD , USA.

Objective: This qualitative study sought to identify and describe patients' variant perceptions of disease severity after receiving a type 2 diabetes (T2DM) or prediabetes (preDM) diagnosis.

Design: Researchers interviewed 29 patients from two US medical centers to ascertain perceptions of severity. We used the constant comparative method from a grounded theory approach to identify themes from patients' perspectives that inform their disease severity. Read More

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http://dx.doi.org/10.1080/08870446.2019.1604955DOI Listing

Metabolic Determinants of Weight Gain in Humans.

Authors:
Paolo Piaggi

Obesity (Silver Spring) 2019 May;27(5):691-699

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.

One of the fundamental challenges in obesity research is to identify subjects prone to weight gain so that obesity and its comorbidities can be promptly prevented or treated. The principles of thermodynamics as applied to human body energetics demonstrate that susceptibility to weight gain varies among individuals as a result of interindividual differences in energy expenditure and energy intake, two factors that counterbalance one another and determine daily energy balance and, ultimately, body weight change. This review focuses on the variability among individuals in human metabolism that determines weight change. Read More

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http://dx.doi.org/10.1002/oby.22456DOI Listing

Mediterranean versus Western Diet Effects on Caloric Intake, Obesity, Metabolism, and Hepatosteatosis in Nonhuman Primates.

Obesity (Silver Spring) 2019 May;27(5):777-784

Department of Pathology and Comparative Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.

Objective: This study aimed to determine the effects of humanlike Western and Mediterranean diets on caloric intake, obesity, metabolism, and hepatosteatosis in an established nonhuman primate model of obesity, cardiometabolic syndrome, type 2 diabetes, and atherosclerosis.

Methods: A 38-month, randomized, preclinical, nonhuman primate primary prevention trial of 38 socially housed, middle-aged adult females was conducted. The monkeys were characterized during a 7-month baseline phase while consuming chow and then randomized to either Western or Mediterranean diets; the groups were balanced on baseline characteristics. Read More

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http://dx.doi.org/10.1002/oby.22436DOI Listing

Effect of Obesogenic Medications on Weight-Loss Outcomes in a Behavioral Weight-Management Program.

Obesity (Silver Spring) 2019 May;27(5):716-723

Veterans Affairs San Diego Healthcare System, San Diego, California, USA.

Objective: This study aimed to evaluate a possible association between the use of obesogenic medications and inadequate weight loss in a behavioral weight-management program.

Methods: This is a case-control, single-center study of 666 adult patients within a Veterans Health Administration health system who participated in the MOVE! behavioral weight-loss program. The cohort was divided into responders (n = 150), patients who achieved ≥ 5% total weight loss by the end of the MOVE! program, and nonresponders (n = 516), those who achieved < 5% total weight loss. Read More

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http://doi.wiley.com/10.1002/oby.22444
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http://dx.doi.org/10.1002/oby.22444DOI Listing
May 2019
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Matrix metalloproteinase-9 gene polymorphisms are associated with ischemic stroke severity and early neurologic deterioration in patients with atrial fibrillation.

Brain Behav 2019 Apr 22:e01291. Epub 2019 Apr 22.

Department of Neurology, People's Hospital of Deyang City, Deyang, China.

Objectives: The mechanisms of ischemic stroke severity and early neurologic deterioration (END) are not fully understood. The aim of the present study was to investigate the association of six variants in MMP-9 gene with ischemic stroke severity and the risk for END in ischemic stroke (IS) patients with atrial fibrillation (AF).

Methods: This was a multi-center, prospective, observational study of 615 acute IS patients with AF admitted to six participating hospitals between June 2016 and October 2017. Read More

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http://dx.doi.org/10.1002/brb3.1291DOI Listing

A novel missense mutation in TFAP2B associated with Char syndrome and central diabetes insipidus.

Am J Med Genet A 2019 Apr 22. Epub 2019 Apr 22.

Division of Newborn Medicine, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.

Char syndrome is characterized by persistent patent ductus arteriosus (PDA) associated with hand-skeletal abnormalities and distinctive facial dysmorphism. Pathogenic variants in the transcription factor gene TFAP2B have been shown to cause Char syndrome; however, there is significant phenotypic variability linked to variant location. Here, we report a pediatric patient with a novel de novo variant in the fifth exon of TFAP2B, c. Read More

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http://dx.doi.org/10.1002/ajmg.a.61150DOI Listing
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