665,679 results match your criteria Diabetes & Metabolism [Journal]


Maternal Glycemic Control in Type 1 Diabetes and the Risk for Preterm Birth: A Population-Based Cohort Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Karolinska Institutet, Stockholm, Sweden, and Statens Serum Institut, Copenhagen, Denmark (B.P.).

Background: Maternal type 1 diabetes (T1D) has been linked to preterm birth and other adverse pregnancy outcomes. How these risks vary with glycated hemoglobin (or hemoglobin A1c [HbA1c]) levels is unclear.

Objective: To examine preterm birth risk according to periconceptional HbA1c levels in women with T1D. Read More

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http://dx.doi.org/10.7326/M18-1974DOI Listing

Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana (J.W.A., K.M.G.).

Background: Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management.

Objective: To identify some predictors of LTWL.

Design: The DPP (Diabetes Prevention Program) was a randomized controlled trial that compared weight loss with metformin, intensive lifestyle intervention (ILS), or placebo. Read More

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http://dx.doi.org/10.7326/M18-1605DOI Listing

Multitarget PPARγ agonists as innovative modulators of the metabolic syndrome.

Eur J Med Chem 2019 Apr 13;173:261-273. Epub 2019 Apr 13.

Department of Pharmacy, University of Chieti "G. d.Annunzio", Via Dei Vestini, 31, 66100, Chieti, Italy.

A multitarget pharmacologic approach could be advantageous for the therapy of metabolic multiple diseases, such as the metabolic syndrome, which is characterized by metabolic abnormalities associated with diabetes, obesity, hypertension, and increased cardiovascular risk. PPAR receptors play a critical role in metabolic disorders, affecting glucose and lipid metabolism. Drugs simultaneously targeting PPAR and other validated metabolic targets, represent a promising multitarget approach to combine antihyperglycemic, antihyperlipidemic, and antihypertensive effects. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.030DOI Listing

The association between metformin therapy and risk of gynecological cancer in patients: Two meta-analyses.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:33-41. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Recently, metformin, first-line drug for type 2 diabetes, has been reported to treat some gynecological tumors. However, these epidemiological studies have never been formally summarized. Considering a single study may lack the power to provide reliable conclusion, we performed two meta-analyses with different indicators to assess metformin's role in reducing the risk of gynecological cancers. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.029DOI Listing

Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses.

Phytomedicine 2018 Nov 28;59:152774. Epub 2018 Nov 28.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address:

Background: Diabetes mellitus is a well-known risk factor for the development of heart failure. Inflammation and oxidative stress play a key role in the development of diabetic cardiomyopathy (DCM), and this nexus represents an attractive target to combat this disease. Naturally occurring flavonoid luteolin exhibits both anti-inflammatory and antioxidant activities in various systems. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.034DOI Listing
November 2018

Risk Factors for Severe Liver Disease in Patients With Type 2 Diabetes.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Upper Gastrointestinal Diseases, Division of Hepatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Background & Aims: Type 2 diabetes is a risk factor for development of cirrhosis and hepatocellular carcinoma. However, risk factor that identify persons with the highest risk for these outcomes are missing from unselected, population-based cohorts.

Methods: The National Diabetes Register contains data on about 90% of persons in Sweden with type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.038DOI Listing

Lower hemoglobin levels are associated with acute seizures in patients with ruptured cerebral aneurysms.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China. Electronic address:

Objective: We test the hypothesis that low hemoglobin levels are associated with acute seizures following aneurysmal subarachnoid hemorrhage (aSAH).

Methods: Patients with ruptured intracranial aneurysms were enrolled in the observational cohort study that prospectively collected age, sex, symptom onset, history of diabetes and hypertension, history of coronary artery disease, temperature, Hunt-Hess grade, Fisher grade, aneurysm location, hemoglobin, hematocrit, serum potassium, sodium, calcium, phosphorus, iron, and modified Rankin Scale (mRS). Acute seizures were determined as seizures within one week following aSAH. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.115DOI Listing

STENT GRAFT LENGTH IS ASSOCIATED WITH DECREASED PATENCY IN TREATMENT OF CENTRAL VENOUS STENOSIS IN HEMODIALYSIS PATIENTS.

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

St. Louis University, Saint Louis, MO, USA. Electronic address:

Objectives: Central venous occlusion may occur in hemodialysis patients resulting in arm or facial swelling and failure of dialysis access. Endovascular management with balloon angioplasty or stenting has been described, but there is minimal data on the use of covered stents in this pathology. We sought to review a single institution's experience with the use of covered stents for central venous occlusive disease in hemodialysis patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096193025
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http://dx.doi.org/10.1016/j.avsg.2019.01.024DOI Listing
April 2019
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Identification of arylsulfatase B gene mutations and clinical presentations of Iranian patients with Mucopolysaccharidosis VI.

Gene 2019 Apr 19. Epub 2019 Apr 19.

Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Background: Mucopolysaccharidosis (MPS) type VI, also known as Maroteaux-Lamy syndrome, is an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase B (ARSB) enzyme. Our objectives were to investigate clinical phenotypes and performed molecular studies in Iranian patients with MPS VI, for the first time, in the southwestern Iran.

Methods: We studied 14 cases from 10 unrelated kindreds with MPS VI that were enrolled during 8 years. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193040
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http://dx.doi.org/10.1016/j.gene.2019.04.050DOI Listing
April 2019
1 Read

Streptozotocin causes acute responses on hippocampal S100B and BDNF proteins linked to glucose metabolism alterations.

Neurochem Int 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Streptozotocin (STZ) is a glucosamine-nitrosourea commonly used to induce long-lasting models of diabetes mellitus and Alzheimer's disease. Direct toxicity of STZ on the pancreas and kidneys has been well characterized, but the acute effect of this compound on brain tissue has received less attention. Herein, we investigated the acute and direct toxicity of STZ on fresh hippocampal slices, measuring changes in BDNF and S100B secretion (two widely-used peripheral markers of brain injury), as well as glucose metabolism. Read More

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http://dx.doi.org/10.1016/j.neuint.2019.04.013DOI Listing

Ameliorative effect of zinc supplementation on compromised small intestinal health in streptozotocin-induced diabetic rats.

Chem Biol Interact 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry, CSIR - Central Food Technological Research Institute, Mysore, 570 020, India. Electronic address:

Zinc depletion during diabetes postulates a role for zinc nutrition in the management of associated complications. The present study evaluated zinc supplementation for countering the compromised intestinal integrity through moderation of oxidative stress and suppression of stress-stimulated inflammatory proliferation in streptozotocin-induced diabetic rats. Diabetic rats were provided with supplemental zinc for six weeks (5 and 10-times of normal level). Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.018DOI Listing

Diabetic retinopathy: Focus on NADPH oxidase and its potential as therapeutic target.

Eur J Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, 410008, China. Electronic address:

Diabetic retinopathy is a common complication of diabetes that affects the retina due to a sustained high blood sugar level. Recent studies have demonstrated that high glucose-driven oxidative stress plays an important role in the microvascular complications of retina in diabetes. Oxidative stress occurs due to the excess of reactive oxygen species, which causes oxidative damage to retina, leading to the leak of tiny blood vessels, or acts as signaling molecules to trigger neovascularization, resulting in new fragile vessels. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.038DOI Listing

Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition.

Eur J Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Biomedical Engineering Research Center, Kunming Medical University, Kunming, 650500, China. Electronic address:

Hyperuricaemia, which results from the overproduction and underexcretion of uric acid, has been linked with chronic renal dysfunction, cardiovascular diseases, diabetes and metabolic syndrome. However, available clinical drugs cannot simultaneously target the production and excretion of uric acid. Norathyriol, a natural xanthone, was expected to have the dual actions. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.034DOI Listing

Changes in Retinal Microcirculation Precede the Clinical Onset of Diabetic Retinopathy in Children with Type 1 Diabetes Mellitus.

Am J Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Endocrinology, Dr. Sami Ulus Children's Health and Disease Training and Research Hospital, Ankara, Turkey.

Purpose: To investigate whether abnormal glucose metabolism in diabetes mellitus (DM) affects the retinal microcirculation of children with well-controlled type 1 DM and to compare these results with those obtained from healthy children.

Design: Cross-sectional prospective study.

Methods: This study enrolled 60 patients with DM without clinically detectable diabetic retinopathy (DR) and who met 57 age-matched controls. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.04.011DOI Listing

Associations of marital status with diabetes, hypertension, cardiovascular disease and all-cause mortality: A long term follow-up study.

PLoS One 2019 22;14(4):e0215593. Epub 2019 Apr 22.

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, ShahidBeheshti University of Medical Sciences, Tehran, Iran.

Background: To investigate the associations of marital status with major clinical outcomes including type 2 diabetes (T2D), hypertension, cardiovascular disease (CVD) and all-cause mortality.

Methods: The study cohort (1999-2014) included 9,737 (45% male) Iranian adults with a mean age of 47.6 years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215593PLOS
April 2019
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Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function.

PLoS One 2019 22;14(4):e0215617. Epub 2019 Apr 22.

Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: C1q TNF related protein 3 (CTRP3) is an adipokine secreted from adipose tissue. Previous studies have suggested that CTRP3 improves insulin sensitivity and reduces inflammation. Human studies have evaluated circulating levels of this adipokine in patients with diabetes mellitus (DM), diabetic retinopathy, metabolic syndrome, and coronary artery diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215617PLOS

Prevalence, awareness and control of diabetes in Russia: The Ural Eye and Medical Study on adults aged 40+ years.

PLoS One 2019 22;14(4):e0215636. Epub 2019 Apr 22.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: Non-communicable chronic diseases have become the leading causes of mortality and disease burden worldwide. With information about the frequency of diabetes as a major non-communicable chronic disease in Russia being scarce, we assessed the prevalence of diabetes and its associated factors in a rural and urban population in Russia.

Methods: The Ural Eye and Medical Study is a population-based study in the city of Ufa/Russia and in villages in a distance of 65 km from Ufa. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215636PLOS
April 2019
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Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos.

PLoS One 2019 22;14(4):e0215378. Epub 2019 Apr 22.

Institute for Minority Health Research, University of Illinois at Chicago, Chicago, Illinois, United States of America.

Objective: Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hispanic/Latino backgrounds. We investigated cognitive associations with cardiovascular disease risk factor burden in a diverse cohort, the Hispanic Community Health Study/Study of Latinos. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215378PLOS
April 2019
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Longevity-Associated Forkhead Box O3 (FOXO3) Single Nucleotide Polymorphisms are Associated with Type 2 Diabetes Mellitus in Chinese Elderly Women.

Med Sci Monit 2019 Apr 22;25:2966-2975. Epub 2019 Apr 22.

Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan Univesity, Shanghai, China (mainland).

BACKGROUND This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) of Forkhead box O3 (FOXO3) gene with type 2 diabetes mellitus (T2D). MATERIAL AND METHODS A total of 843 elderly residents from east China were enrolled in this study, which included 426 patients with type 2 diabetes and 417 controls. Four SNPs were analyzed by qPCR. Read More

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http://dx.doi.org/10.12659/MSM.913788DOI Listing

Dermal Calcium Loss is Not the Primary Determinant of PTH Secretion during Exercise.

Med Sci Sports Exerc 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine, Division of Geriatric Medicine, University of Colorado Denver, Aurora, CO.

Introduction: Exercise can cause a decrease in serum ionized calcium (iCa) concentration, which stimulates parathyroid hormone (PTH) secretion and activates bone resorption. We postulated that dermal Ca loss during cycling exercise is the major determinant of the serum iCa, PTH, and bone resorption (C-terminal telopeptide of type 1 collagen; CTX) responses.

Methods: To investigate this, women (n=13) and men (n=12) aged 18 to 45 years performed the same exercise bout under cool (18°C) and warm (26°C) conditions. Read More

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http://dx.doi.org/10.1249/MSS.0000000000002017DOI Listing
April 2019
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Effects of an Intensive Discharge Intervention on Medication Adherence, Glycemic Control, and Readmission Rates in Patients With Type 2 Diabetes.

J Patient Saf 2019 Apr 18. Epub 2019 Apr 18.

Objectives: Patients with diabetes are at particularly high risk for adverse outcomes after hospitalization. The goals of this study were to design, implement, and evaluate a multipronged transitional care intervention among hospitalized patients with diabetes.

Methods: We randomly assigned inpatients likely to be discharged home on insulin to an intensive transitional care intervention or usual care. Read More

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http://dx.doi.org/10.1097/PTS.0000000000000601DOI Listing
April 2019
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Clinical and Demographic Trends in Cardiac Rehabilitation: 1996-2015.

J Cardiopulm Rehabil Prev 2019 Apr 18. Epub 2019 Apr 18.

University of Vermont College of Medicine, Burlington (Drs Gaalema, Naud, Priest, and Ades); and University of Vermont Medical Center, Burlington (Messrs Savage and Rengo and Drs Leadholm and Ades).

Purpose: Clinical interventions in programs such as cardiac rehabilitation (CR) are guided by clinical characteristics of participating patients. This study describes changes in CR participant characteristics over 20 yr.

Methods: To examine changes in patient characteristics over time, we analyzed data from 1996 to 2015 (n = 5396) garnered from a systematically and prospectively gathered database. Read More

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http://dx.doi.org/10.1097/HCR.0000000000000390DOI Listing

Risk Factors for Acute Ischemic Stroke Caused by Anterior Large Vessel Occlusion.

Stroke 2019 May;50(5):1074-1080

From the Department of Neurosurgery (P.H., N.S., O.G., C.M.S., C.J.G.), Geisinger, Danville, PA.

Background and Purpose- Accurate prediction of acute ischemic stroke (AIS) caused by anterior large vessel occlusion (LVO) that is amendable to mechanical thrombectomy remains a challenge. We developed and validated a prediction model for anterior circulation LVO stroke using past medical history elements present on admission and neurological examination. Methods- We retrospectively reviewed AIS patients admitted between 2009 and 2017 to 3 hospitals within a large healthcare system in the United States. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023917DOI Listing

Acute Stroke With Large Ischemic Core Treated by Thrombectomy.

Stroke 2019 May;50(5):1164-1171

Department of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France (B.L.).

Background and Purpose- Acute stroke patients with a large ischemic core may still benefit from mechanical thrombectomy (MT), but the predictors of clinical outcome are not well known after MT. We investigated the clinical and imaging factors associated with good outcome and mortality at 90 days in acute stroke patients with a large baseline ischemic core treated with MT. Methods- Data from the multicentric prospective ETIS (Endovascular Treatment in Ischemic Stroke) registry of consecutive acute ischemic stroke patients treated with MT from January 1, 2012, to August 31, 2016, were retrospectively analyzed. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.024295DOI Listing

Intracranial Atherosclerotic Disease.

Stroke 2019 May;50(5):1286-1293

Department of Neurology, Neurovascular Imaging Research Core and UCLA Stroke Center, University of California at Los Angeles (D.S.L.).

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http://dx.doi.org/10.1161/STROKEAHA.118.024147DOI Listing

Storage Conditions of Insulin in Domestic Refrigerators and When Carried by Patients: Often Outside Recommended Temperature Range.

Diabetes Technol Ther 2019 Apr 19. Epub 2019 Apr 19.

3 Science & Co., Neuss, Germany.

Not much is known about how people with diabetes store their insulin. Objective of our evaluation was to analyze at which temperature insulin is stored in domestic refrigerators and when opened/carried as a spare, and if these temperatures meet the manufacturers' recommendations. People with diabetes ( = 338; 46% US, 41% EU) put Bluetooth-enabled temperature sensors (MedAngel ONE, Netherlands) next to the insulin into their refrigerator or diabetes bag. Read More

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https://www.liebertpub.com/doi/10.1089/dia.2019.0046
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http://dx.doi.org/10.1089/dia.2019.0046DOI Listing
April 2019
1 Read

The aldosterone to renin ratio (ARR) in the diagnosis of primary aldosteronism (PA): promises and challenges.

Int J Clin Pract 2019 Apr 22:e13353. Epub 2019 Apr 22.

Department of Clinical Biochemistry & Diagnostic Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.

The complexity of evaluating patients for secondary treatable causes of hypertension is underappreciated. Primary aldosteronism (PA) is the most prevalent cause of secondary hypertension (3% to 32% of hypertensive patients). The recent endocrine society clinical practice guideline (ESCPG), "The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment", differs from the previous version in the explicit recognition of PA as a major public health issue. Read More

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http://dx.doi.org/10.1111/ijcp.13353DOI Listing

Role of β-3 adrenergic receptor polymorphism in overactive bladder.

Neurourol Urodyn 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, Division of Urogynecology, Duke University School of Medicine, Durham, North Carolina.

Aims: Women with overactive bladder (OAB) have a higher frequency of a single-nucleotide polymorphism (SNP) at codon 64 of the β-3 adrenergic receptor gene (ADRB3). Since the SNP results in an amino acid substitution that could theoretically alter receptor protein function, we hypothesized that those with the SNP would display greater OAB symptom severity. Therefore we aimed to compare OAB severity between women with this SNP and women with the wild type genotype. Read More

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http://dx.doi.org/10.1002/nau.24006DOI Listing

Rituximab for treatment of refractory insulin autoimmune syndrome associated with non-Hodgkin B-cell lymphoma.

Clin Endocrinol (Oxf) 2019 Apr 22. Epub 2019 Apr 22.

Southern Adelaide Diabetes and Endocrine Services, Marion, AUSTRALIA.

Insulin autoimmune syndrome (IAS or Hirata's Disease) is a rare cause of spontaneous hypoglycaemia. In IAS circulating autoantibodies bind endogenous insulin rendering insulin inactive. These complexes later dissociate in an unregulated manner resulting in hypoglycaemia. Read More

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http://dx.doi.org/10.1111/cen.13998DOI Listing

Using a surrogate marker for early testing of a treatment effect.

Biometrics 2019 Apr 22. Epub 2019 Apr 22.

Stanford University, Department of Biomedical Data Science, Stanford, California, U.S.A.

The development of methods to identify, validate and use surrogate markers to test for a treatment effect has been an area of intense research interest given the potential for valid surrogate markers to reduce the required costs and follow-up times of future studies. Several quantities and procedures have been proposed to assess the utility of a surrogate marker. However, few methods have been proposed to address how one might use the surrogate marker information to test for a treatment effect at an earlier time point, especially in settings where the primary outcome and the surrogate marker are subject to censoring. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13067
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http://dx.doi.org/10.1111/biom.13067DOI Listing
April 2019
1 Read

Protein-engineered molecules carrying GAD65 epitopes and targeting CD35 selectively down-modulate disease-associated human B lymphocytes.

Clin Exp Immunol 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Experimental Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.

Background: Type 1 diabetes mellitus is an autoimmune metabolic disorder characterized by chronic hyperglycemia, presence of autoreactive T and B cells and autoantibodies against self-antigens. A membrane-bound enzyme on the pancreatic beta-cells, GAD 65, is one of the main autoantigens in type 1 diabetes. Autoantibodies against GAD65 are potentially involved in beta-cells destruction and decline of pancreatic functions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cei.13305
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http://dx.doi.org/10.1111/cei.13305DOI Listing
April 2019
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Blood Pressure Profile, Catecholamine Phenotype and Target Organ Damage in Pheochromocytoma/Paraganglioma.

J Clin Endocrinol Metab 2019 Apr 22. Epub 2019 Apr 22.

Center of Hypertension, 3rd Department of Medicine, First Faculty of Medicine and General Faculty Hospital, Charles University in Prague, Czech Republic.

Context: Impaired diurnal blood pressure (BP) variability is related to higher cardiovascular risk.

Objective: To assess diurnal variability of BP and its relation to target organ damage (TOD) and catecholamine phenotype in a consecutive sample of pheochromocytoma/paraganglioma (PPGL).

Design: We included 179 patients with PPGL (96 females). Read More

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http://dx.doi.org/10.1210/jc.2018-02644DOI Listing

Association Between Receipt of a Medically Tailored Meal Program and Health Care Use.

JAMA Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Mongan Institute, Massachusetts General Hospital, Boston.

Importance: Whether interventions to improve food access can reduce health care use is unknown.

Objective: To determine whether participation in a medically tailored meal intervention is associated with fewer subsequent hospitalizations.

Design, Setting, And Participants: A retrospective cohort study was conducted using near/far matching instrumental variable analysis. Read More

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http://archinte.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamainternmed.2019.0198DOI Listing
April 2019
1 Read

Maternal lipid profiles in women with and without gestational diabetes mellitus.

Medicine (Baltimore) 2019 Apr;98(16):e15320

Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing, China.

To determine the longitude lipid profiles in women with and without gestational diabetes mellitus (GDM), and to investigate the relationship between lipid disturbances in the 1st trimester and GDM.Blood samples were collected from 1283 normal pregnant women and 300 women with GDM. Serum lipids which include total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured and the TG/HDL-C ratio was calculated in the 1st, 2nd, and 3rd trimesters of pregnancy and then we got the longitudinal lipid profiles. Read More

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http://dx.doi.org/10.1097/MD.0000000000015320DOI Listing

Schizoaffective disorder comorbid with type 2 diabetes mellitus accompanied by frontotemporal atrophy and impaired cognition: A CARE compliant case report.

Medicine (Baltimore) 2019 Apr;98(16):e15292

Department of Affective Disorder, Shenzhen Kangning Hospital, Luohu District, Shenzhen, China.

Rationale: Brain atrophy coupled with impaired cognition may be a sign of dementia. However, growing evidence indicates that schizoaffective disorder (SAD) and type 2 diabetes mellitus (T2DM) play roles in the processes of frontotemporal atrophy and cognitive decline. Few cases of frontotemporal atrophy and impaired cognition have been reported in young adult patients with SAD and T2DM. Read More

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http://dx.doi.org/10.1097/MD.0000000000015292DOI Listing
April 2019
1 Read

An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15246

Peking University China-Japan Friendship School of Clinical Medicine.

Rationale: Mucinous cystic neoplasms (MCNs) are relatively rare lesions, accounting for 2%-5% of all exocrine pancreatic neoplasms. MCNs mainly occur in women (female:male ratio = 20:1), with a peak incidence in the 5th decade of life. Osteoclast-like giant cell tumors (OGCTs) are rare and relatively aggressive neoplasms, comprising <1% of all pancreatic carcinomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000015246DOI Listing

Clinical course and risk factors of recurrent corneal erosion: Observational study.

Medicine (Baltimore) 2019 Apr;98(16):e14964

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo 173-8605.

Recurrent corneal erosion (RCE) is a common disorder causing ocular pain, tearing, photophobia, and visual impairments. Various factors such as ocular trauma, ocular surgery, corneal dystrophy, contact lens wear, and diabetes mellitus (DM) can cause RCE. The purpose of this study was to determine the causative factors and clinical course of RCE. Read More

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http://dx.doi.org/10.1097/MD.0000000000014964DOI Listing

Structure-function relationships in peripheral nerve contributions to diabetic peripheral neuropathy.

Pain 2019 May;160 Suppl 1:S29-S36

Department of Molecular Pharmacology, Institute of Pharmacology, Heidelberg University, Heidelberg, Germany.

Diabetes mellitus (DM) is a major global health concern, affecting more than 9% of the world population. The most common complication of DM is diabetic peripheral neuropathy (DPN), which leads to neuropathic pain in as many as 50% of patients. Despite its prevalence, there is neither good prevention of nor treatments for DPN, representing a major gap in care for the many who are afflicted. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001530DOI Listing

Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.

Authors:
Aaron DiAntonio

Pain 2019 May;160 Suppl 1:S17-S22

Department of Developmental Biology, Washington University Medical School Saint Louis, Saint Louis, MO, United States.

Peripheral neuropathy is the most common neurodegenerative disease affecting hundreds of millions of patients worldwide and is an important cause of chronic pain. Typical peripheral neuropathies are characterized by dysesthesias including numbness, crawling skin, a sensation of "pins and needles," and burning and stabbing pain. In addition, peripheral neuropathy can affect the motor and autonomic systems leading to symptoms such as weakness, constipation, and dysregulation of blood pressure. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001528DOI Listing

Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.

Pain 2019 05;160(5):1103-1118

Division of Pharmacology and Toxicology, Department of NEUROFARBA, University of Florence, Italy.

Recently, studies have focused on the antihyperalgesic activity of the A3 adenosine receptor (A3AR) in several chronic pain models, but the cellular and molecular basis of this effect is still unknown. Here, we investigated the expression and functional effects of A3AR on the excitability of small- to medium-sized, capsaicin-sensitive, dorsal root ganglion (DRG) neurons isolated from 3- to 4-week-old rats. Real-time quantitative polymerase chain reaction experiments and immunofluorescence analysis revealed A3AR expression in DRG neurons. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001488DOI Listing
May 2019
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Pregnancy Complications as a Window to Future Cardiovascular Disease.

Cardiol Rev 2019 Apr 12. Epub 2019 Apr 12.

Department of Obstetrics and Gynecology University of Michigan, Ann Arbor, Mi.

Pregnancy is a time of significant hemodynamic, metabolic, and hormonal stress that can unmask underlying subclinical cardiovascular abnormalities, and pregnancy-related complications may serve as early warning signs for future risk of cardiovascular disease. The increased recognition of these sex-specific risk factors could identify women who may benefit from more intensive risk factor modification to reduce morbidity and mortality later in life. In this review, we describe several pregnancy-related complications that have been associated with the risk of cardiovascular disease, including hypertensive disorders of pregnancy, gestational diabetes mellitus, preterm delivery, and pregnancy loss. Read More

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http://dx.doi.org/10.1097/CRD.0000000000000253DOI Listing

Small Intestinal Bacterial Overgrowth Is Common in Chronic Pancreatitis and Associates With Diabetes, Chronic Pancreatitis Severity, Low Zinc Levels, and Opiate Use.

Am J Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.

Objectives: Small intestinal bacterial overgrowth (SIBO) is often present in patients with chronic pancreatitis (CP) with persistent steatorrhea, despite pancreatic enzyme replacement therapy. Overall prevalence of SIBO, diagnosed by glucose breath test (GBT), varies between 0% and 40% but 0%-21% in those without upper gastrointestinal (GI) surgery. We investigated the prevalence and nonsurgical independent predictors of SIBO in CP without upper GI surgery. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000200DOI Listing

Diabetes, Care Homes, and the Influence of Technology on Practice and Care Delivery in Care Homes: Systematic Review and Qualitative Synthesis.

JMIR Diabetes 2019 Apr 22;4(2):e11526. Epub 2019 Apr 22.

Division of Rural Health and Wellbeing, Centre for Health Science, University of the Highlands and Islands, Inverness, United Kingdom.

Background: Diabetes is increasing in prevalence and complexity in the care home setting, affecting up to a quarter of care home residents. Health outcomes for these residents are impacted by management of the disease, health care professionals (HCPs)' decision-making skills within the care home setting, and access to specialist services. The use of technology has the potential to recognize opportunities for early intervention that enables efficient responsive care, taking a fundamental role in linking the care home community to wider multidisciplinary teams for support. Read More

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http://dx.doi.org/10.2196/11526DOI Listing

Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract.

J Am Coll Nutr 2019 Apr 22:1-11. Epub 2019 Apr 22.

b TPM Bioactives Division , The Product Makers Pty Ltd , Melbourne , Australia.

Objectives: Dysfunctional metabolism of carbohydrates is a fundamental component of many dietary-related disorders. It has been hypothesized that plant extracts containing high levels of antioxidants may have the ability to stabilize carbohydrate regulation. The aim of this study was to assess the effects of a polyphenol-rich sugarcane extract on cellular pathways related to carbohydrate metabolism. Read More

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http://dx.doi.org/10.1080/07315724.2019.1587323DOI Listing

Prediction of exocrine and endocrine insufficiency after pancreaticoduodenectomy using volumetry.

Acta Chir Belg 2019 Apr 22:1-22. Epub 2019 Apr 22.

a Department of Hepatobiliary, Endocrine and Transplantation Surgery , Antwerp University Hospital , Belgium.

Objectives: The aim of this study is to evaluate the use of pancreatic volumetric assessment to predict exocrine and endocrine insufficiency after pancreaticoduodenectomy.

Methods: Thirty-seven patients who underwent pancreaticoduodenectomy were included in the study. Endocrine function was assessed in all patients without a history of diabetes using an oral glucose tolerance test. Read More

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PPAR-δ Activation Ameliorates Diabetes-Induced Cognitive Dysfunction by Modulating Integrin-linked Kinase and AMPA Receptor Function.

J Am Coll Nutr 2019 Apr 22:1-10. Epub 2019 Apr 22.

a Department of Drug Discovery and Development, Harrison School of Pharmacy , Auburn University , Auburn , Alabama , USA.

An estimated 9% of the American population experiences type II diabetes mellitus (T2DM) due to diet or genetic predisposition. Recent reports indicate that patients with T2DM are at increased risk for cognitive dysfunctions, as observed in conditions like Alzheimer's disease (AD). In addition, AD is the leading cause of dementia, highlighting the urgency of developing novel therapeutic targets for T2DM-induced cognitive deficits. Read More

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http://dx.doi.org/10.1080/07315724.2019.1598307DOI Listing

Efficacy of intratympanic corticosteroid, intravenous batroxobin and combined treatment for sudden sensorineural hearing loss with type-2 diabetes.

Acta Otolaryngol 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Department of Otorhinolaryngology Head and Neck Surgery , Beijing Anzhen Hospital, Capital Medical University , Beijing , China.

Background: Intratympanic corticosteroid (IC), intravenous batroxobin (IB) as the treatment for sudden sensorineural hearing loss (SSNHL) has been reported. However, the data on combination therapy (CT) was scarce.

Objective: The aim of this retrospective study was to compare the efficacy of IC, IB, and CT in the treatment of SSNHL with diabetes. Read More

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http://dx.doi.org/10.1080/00016489.2019.1592221DOI Listing

Depression and multimorbidity: Considering temporal characteristics of the associations between depression and multiple chronic diseases.

Health Psychol 2019 Apr 22. Epub 2019 Apr 22.

Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center.

Objectives: Depression frequently co-occurs with multiple chronic diseases in complex, costly, and dangerous patterns of multimorbidity. The field of health psychology may benefit from evaluating the temporal characteristics of depression's associations with common diseases, and from determining whether depression is a central connector in multimorbid disease clusters. The present review addresses these issues by focusing on 4 of the most prevalent diseases: hypertension, ischemic heart disease, arthritis, and diabetes. Read More

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http://dx.doi.org/10.1037/hea0000737DOI Listing

The presentation of neuroendocrine self-peptides in the thymus: an essential event for individual life and vertebrate survival.

Ann N Y Acad Sci 2019 Apr 22. Epub 2019 Apr 22.

GIGA Institute, University of Liège, Liège-Sart Tilman, Belgium.

Confirming Burnet's early hypothesis, elimination of self-reactive T cells in the thymus was demonstrated in the late 1980s, and an important question immediately arose about the nature of the self-peptides expressed in the thymus. Many genes encoding neuroendocrine-related and tissue-restricted antigens (TRAs) are transcribed in thymic epithelial cells (TECs). They are then processed for presentation by proteins of the major histocompatibility complex (MHC) expressed by TECs and thymic dendritic cells. Read More

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http://dx.doi.org/10.1111/nyas.14089DOI Listing

Whole Egg Consumption Impairs Insulin Sensitivity in a Rat Model of Obesity and Type 2 Diabetes.

Curr Dev Nutr 2019 Apr 11;3(4):nzz015. Epub 2019 Mar 11.

Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011.

Background: The literature regarding the relation between egg consumption and type 2 diabetes (T2D) is inconsistent and there is limited evidence pertaining to the impact of egg consumption on measures of insulin sensitivity.

Objectives: The aim of this study was to investigate the effect of dietary whole egg on metabolic biomarkers of insulin resistance in T2D rats.

Methods: Male Zucker diabetic fatty (ZDF) rats ( = 12; 6 wk of age) and age-matched lean controls ( = 12) were randomly assigned to be fed a casein- or whole egg-based diet. Read More

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http://dx.doi.org/10.1093/cdn/nzz015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462456PMC
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