657,890 results match your criteria Diabetes & Metabolism [Journal]


The Cost of Hypoglycemia Associated With Type 2 Diabetes Mellitus in Taiwan.

Value Health Reg Issues 2019 Feb 15;18:84-90. Epub 2019 Feb 15.

Lilly Diabetes, Eli Lilly and Co (Taiwan), Taipei, Taiwan.

Objectives: To quantify the incremental burden of patients with type 2 diabetes mellitus (T2DM) and a hypoglycemic event in Taiwan using the National Health Insurance Research Database.

Methods: Data from 2000 through 2013 with an index period of 2001 through 2012 from the National Health Insurance Research Database's 2-million-patient sample were used. Using a nested case-control study design, patients were indexed if they reported a diagnosis of T2DM during the index period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vhri.2019.01.002DOI Listing
February 2019

Dietary exposure to polychlorinated biphenyls and risk of heart failure - A population-based prospective cohort study.

Environ Int 2019 Feb 15;126:1-6. Epub 2019 Feb 15.

Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. Electronic address:

Background: Beneficial effects of fish consumption on heart failure (HF) may be modified by contaminants in fish. Polychlorinated biphenyls (PCBs) are of particular concern as they have been associated with well-established risk factors of HF, but current data are limited.

Objectives: We aimed to assess the association between dietary PCB exposure and risk of HF, accounting for dietary intake of long-chain omega-3 fish fatty acids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2019.01.069DOI Listing
February 2019

Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products.

Differentiation 2019 Jan 28;105:54-70. Epub 2019 Jan 28.

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Diabetes Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Irwin S. and Sylvia Chanin Institute for Cancer Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Endogenous cell signals regulate tissue homeostasis and are significant for directing the fate of stem cells. During liver development, cytokines released from various cell types are critical for stem/progenitor cell differentiation and lineage expansions. To determine mechanisms in these stage-specific lineage interactions, we modeled potential effects of soluble signals derived from immortalized human fetal liver parenchymal cells on stem cells, including embryonic and induced pluripotent stem cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diff.2019.01.005DOI Listing
January 2019

Advanced gastric cancer with features of a submucosal tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration and boring biopsy preoperatively: A case report and literature review.

Int J Surg Case Rep 2019 Feb 8;55:223-226. Epub 2019 Feb 8.

Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Introduction: Gastric cancer with features of a submucosal tumor (GCSMT) is rare, and the preoperative diagnosis is very difficult. We present a case of GCSMT diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and boring biopsy (deeper biopsy), successfully treated with distal gastrectomy and lymph node dissection.

Presentation Of Case: An 81-year-old man with a history of myocardial infarction and type 2 diabetes mellitus was admitted to our hospital for further examination of a gastric submucosal tumor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2019.01.044DOI Listing
February 2019

Polyoxomolybdates as α-glucosidase inhibitors: Kinetic and molecular modeling studies.

J Inorg Biochem 2019 Feb 8;193:173-179. Epub 2019 Feb 8.

College of Food and Biological Engineering, Jimei University, Xiamen 361021, PR China.

Noninsulin dependent diabetes mellitus is a serious global disease that is treated by inhibiting α-glucosidase to reduce the glucose content in the blood. Several incompletely satisfactory therapeutic drugs are already on the market. In this report, we showed that polyoxomolybdates based on Keggin-type architecture are promising candidates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2019.02.001DOI Listing
February 2019

Frailty and health risks in an agricultural population, Chile 2014-2017.

Arch Gerontol Geriatr 2019 Feb 10;82:114-119. Epub 2019 Feb 10.

Advanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile; Public Health Department, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile. Electronic address:

Background: Aging presents an emerging health and social challenge. We report the prevalence of frailty, its association with chronic diseases and the risk of hospitalization or death within 29 months.

Methods: Cross-sectional and prospective study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.archger.2019.01.012DOI Listing
February 2019

Single and multi-locus association study of TCF7L2 gene variants with susceptibility to type 2 diabetes mellitus in an Iranian population.

Gene 2019 Feb 15. Epub 2019 Feb 15.

Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Prior studies indicated that some of transcription factor 7-like 2 (TCF7L2) gene variants such as rs7903146, rs12255372 and rs11255372 are constantly associated with Type 2 diabetes mellitus (T2DM) in various populations and ethnic groups. The purpose of this study was to assess the association between TCF7L2 variants (rs7903146, rs11196205, and rs11255372) and T2DM by TaqMan assay. Statistical analysis was performed through SNPAlyze and SPSS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.01.040DOI Listing
February 2019

TELOMERE LENGTH AND HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSES OF OBSERVATIONAL STUDIES.

Ageing Res Rev 2019 Feb 15. Epub 2019 Feb 15.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy; Ambulatory of Nutrition, IRCCS "S. de Bellis" National Institute of Gastroenterology-Research Hospital Castellana Grotte Bari Italy, Italy. Electronic address:

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2019.02.003DOI Listing
February 2019
4.940 Impact Factor

Spontaneous and iatrogenic hypoglycaemia related to mortality in the ICU.

Diabetes Metab 2019 Feb 15. Epub 2019 Feb 15.

Department of Health Science and Technology, Aalborg University, Denmark.

Aim: - Our study investigated the relationship between both spontaneous and iatrogenic hypoglycaemia and mortality.

Methods: - A total of 200,859 patients from the eICU Collaborative Research Database were grouped by whether they had registered episodes of hypoglycaemia or not. Patients with hypoglycaemia were then further divided into subgroups according to type of hypoglycaemia-whether spontaneous or iatrogenic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diabet.2019.02.001DOI Listing
February 2019

Hyperglycemia is associated with psoriatic inflammation in both humans and mice.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. Electronic address:

Chronic low-grade inflammation can cause several metabolic syndromes. Patients with psoriasis, a chronic immunological skin inflammation, often develop diabetes. However, it is not clear to date how psoriasis leads to, or is correlated with, glucose intolerance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2019.01.029DOI Listing
February 2019

The potential contribution of stromal cell-derived factor 2 (SDF2) in endoplasmic reticulum stress response in severe preeclampsia and labor-onset.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 15. Epub 2019 Feb 15.

Institute of Biomedical Sciences, Department of Cell and Developmental Biology, University of São Paulo, São Paulo, SP, Brazil. Electronic address:

Endoplasmic reticulum (ER) stress occurs when the protein folding machinery in the cell is unable to cope with newly synthesized proteins, which results in an accumulation of misfolded proteins in the ER lumen. In response, the cell activates a cellular signaling pathway known as the Unfolded Protein Response (UPR), aiming to restore cellular homeostasis. Activation and exacerbation of the UPR have been described in several human pathologies, including cancer and neurological disorders, and in some gestational diseases such as preeclampsia and gestational diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2019.01.012DOI Listing
February 2019

Ameliorating gut microenvironment through staphylococcal nuclease-mediated intestinal NETs degradation for prevention of type 1 diabetes in NOD mice.

Life Sci 2019 Feb 15. Epub 2019 Feb 15.

China Pharmaceutical University, China. Electronic address:

Aims: Recent studies have revealed that neutrophil extracellular traps (NETs) provide negative feedback in the progression to chronic inflammation and contribute to the pathogenesis of multiple autoimmune diseases including type 1 diabetes (T1D). In addition, accumulating evidences suggest that gut immunity play a key role in T1D pathogenesis. Our study aimed to evaluate whether staphylococcal nuclease (SNase) targeting intestinal NETs can ameliorate the intestinal inflammatory environment and protect against T1D development in non-obese diabetic(NOD) mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.02.034DOI Listing
February 2019

Exogenous obestatin decreases beta-cell apoptosis and alfa-cell proliferation in high fat diet and streptozotocin induced type 2 diabetic rats.

Eur J Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Department of Endocrinology and Metabolism, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address:

Type 2 diabetes is a chronic metabolic disease characterized by progressive decrease of islet cell function. Delaying the process of islet failure remains a challenging goal in diabetes care. Previous studies have confirmed the role of obestatin, a gut peptide that belongs to ghrelin family, in the mediation of glucose metabolism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2019.02.028DOI Listing
February 2019

GLP-1 receptor agonist impairs keratinocytes inflammatory signals by activating AMPK.

Exp Mol Pathol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology and Venerology,Chongqing Three Gorges Central Hospital, ChongQing 404100, China.

Purpose: Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, is an antidiabetic drug. It has been shown to improve the Psoriasis Area and Severity Index (PASI) in patients with type 2 diabetes and psoriasis in clinical practice, but the mechanism remains somewhat unclear. We used lipopolysaccharides (LPS) to induce inflammatory response in keratinocytes and explore the mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2019.01.014DOI Listing
February 2019

Injecting New Ideas Into Managing Type 2 Diabetes: Evolving Roles of GLP-1 Receptor Agonists.

Am J Med 2019 Feb 15. Epub 2019 Feb 15.

Professor of Medicine, The University of Vermont Larner College of Medicine, Director, Endocrinology, The University of Vermont Medical Center, Burlington, Vermont.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjmed.2019.02.001DOI Listing
February 2019

Comorbidities in primary versus secondary school children with obesity and responsiveness to lifestyle intervention.

J Clin Endocrinol Metab 2019 Feb 18. Epub 2019 Feb 18.

Centre for Overweight Adolescent and Children's Healthcare (COACH), Department of Paediatrics, Maastricht University Medical Centre, Maastricht, The Netherlands.

Context: Childhood obesity increases the risk of diseases as diabetes, cardiovascular disease and non-alcoholic fatty liver disease.

Objective: To evaluate the prevalence of comorbidities in school-age children with obesity and to compare its prevalence and the effect of a lifestyle intervention between children in primary and secondary school and between boys and girls.

Design: Cross-sectional analysis and lifestyle intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02318DOI Listing
February 2019

Quality of Life in Hypoparathyroidism Improves with rhPTH(1-84) Throughout 8 Years of Therapy.

J Clin Endocrinol Metab 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, Division of Endocrinology, College of Physicians & Surgeons, Columbia University, New York, NY, USA.

Context: Treatment with calcium and vitamin D does not improve reduced quality of life (QoL) in hypoparathyroidism. rhPTH(1-84) therapy improves QoL metrics for up to 5 years. Data on QoL beyond this 5-yr time point are not available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02430DOI Listing
February 2019

Evaluation of Hypertriglyceridemia as a Mediator Between Endocrine Diseases and Pancreatitis in Dogs.

J Am Anim Hosp Assoc 2019 Mar/Apr;55(2):92-100. Epub 2019 Jan 17.

Veterinary Medical Center, College of Veterinary Medicine (H.K., J-H.K., B-T.K., G.K., D.C., K-J.N., M-P.Y.), and Department of Information and Statistics, College of Natural Science (T-Y.H.), Chungbuk National University, Cheongju, South Korea.

The role of hypertriglyceridemia (HTG) secondary to endocrine diseases in the occurrence of pancreatitis in dogs has not been fully investigated. The objective of the present study was to evaluate HTG as a mediator between endocrine diseases and pancreatitis in dogs. The study design was a retrospective case-control study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5326/JAAHA-MS-6791DOI Listing
January 2019

Short-term exercise training reduces glycaemic variability and lowers circulating endothelial microparticles in overweight and obese women at elevated risk of type 2 diabetes.

Eur J Sport Sci 2019 Feb 18:1-10. Epub 2019 Feb 18.

a Faculty of Health and Social Development, School of Health and Exercise Sciences , University of British Columbia, Okanagan Campus , Kelowna , BC , Canada.

Exercise is recognized as a frontline therapy for the prevention and treatment of type 2 diabetes (T2D) but the optimal type of exercise is not yet determined. We compared the effects of high-intensity interval training (HIIT) with moderate-intensity continuous training (MICT) for improvement of continuous glucose monitoring (CGM)-derived markers of glycaemic variability, and biomarkers of endothelial cell damage (CD31+ and CD62+ endothelial microparticles (EMPs)) within a population at elevated risk of developing T2D. Fifteen inactive overweight or obese women were randomized to 2 weeks (10-sessions) of progressive HIIT (n = 8, 4-10X 1-min @ ∼90% peak heart rate, 1-min rest periods) or MICT (n = 7, 20-50 min of continuous activity at ∼65% peak heart rate). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17461391.2019.1576772DOI Listing
February 2019

Breaking down chronic inflammatory diseases: the role of biglycan in promoting a switch between inflammation and autophagy.

FEBS J 2019 Feb 18. Epub 2019 Feb 18.

Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

It is well established that biglycan, a small leucine-rich proteoglycan, acts as an extracellular matrix-derived danger signal in its soluble form. By binding to innate immunity Toll-like receptors (TLR) 2 and 4, biglycan initiates and perpetuates the inflammatory response. Previous work has conveyed that biglycan's role in inflammation extends far beyond its function as a canonical danger signal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/febs.14791DOI Listing
February 2019

Screening Coronary Angiography in Patients with Long-Standing Diabetes Mellitus undergoing Kidney Transplant Evaluation.

Clin Transplant 2019 Feb 18:e13501. Epub 2019 Feb 18.

Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA.

Background: The Utility of coronary angiography in patients with diabetes mellitus undergoing kidney transplant evaluation is unclear. Predictors of critical angiography lesions in these patients will aid in appropriate use of angiography.

Methods: Single center study of 80 patients with ≥ 15 years of diabetes mellitus who underwent a screening coronary angiography despite a negative cardiac stress test. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ctr.13501DOI Listing
February 2019

Hyperinsulinaemic hypoglycaemia: A new presentation of 16p11.2 deletion syndrome.

Clin Endocrinol (Oxf) 2019 Feb 18. Epub 2019 Feb 18.

Endocrinology Department, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

16p11.2 microdeletion syndrome is a recognisable chromosomal anomaly caused by microdeletions in the 16p11.2 locus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.13951DOI Listing
February 2019

Epidemiology of Invasive Group B Streptococcal Infections Among Nonpregnant Adults in the United States, 2008-2016.

JAMA Intern Med 2019 Feb 18. Epub 2019 Feb 18.

Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: Group B Streptococcus (GBS) is an important cause of invasive bacterial disease. Previous studies have shown a substantial and increasing burden of GBS infections among nonpregnant adults, particularly older adults and those with underlying medical conditions.

Objective: To update trends of invasive GBS disease among US adults using population-based surveillance data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamainternmed.2018.7269DOI Listing
February 2019

Is Alzheimer's Disease Risk Modifiable?

J Alzheimers Dis 2019 ;67(3):795-819

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Population-based clinic-pathological studies have established that the most common pathological substrate of dementia in community-dwelling elderly people is mixed, especially Alzheimer's disease (AD) and cerebrovascular ischemic disease (CVID), rather than pure AD. While these could be just two frequent unrelated comorbidities in the elderly, epidemiological research has reinforced the idea that mid-life (age <65 years) vascular risk factors increase the risk of late-onset (age ≥ 65 years) dementia, and specifically AD. By contrast, healthy lifestyle choices such as leisure activities, physical exercise, and Mediterranean diet are considered protective against AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD181028DOI Listing
January 2019

Midlife Long-Hour Working and Later-life Social Engagement Are Associated with Reduced Risks of Mild Cognitive Impairment among Community-Living Singapore Elderly.

J Alzheimers Dis 2019 ;67(3):1067-1077

The Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China.

Mild cognitive impairment (MCI), as a transitional stage between normal aging and dementia, causes cognitive decline among one-fifth of elders aged 65 years and older. Health-related lifestyles (HRL) are generally regarded as modifiable influencing factors of cognitive decline. The present study investigated how HRLs at two different life stages (one at midlife and the other at later life) affect MCI occurrence among community-dwelling elders, as part of the Diet and Healthy Aging (DaHA) study in Singapore. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180605DOI Listing
January 2019

White Matter Hyperintensities in Alzheimer's Disease: A Lesion Probability Mapping Study.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Medical University of Graz, Graz, Austria.

Background/objective: Higher white matter hyperintensity (WMH) load has been reported in Alzheimer's disease (AD) patients in different brain regions when compared to controls. We aimed to assess possible differences of WMH spatial distribution between AD patients and age-matched controls by means of lesion probability maps.

Methods: The present study included MRI scans of 130 probable AD patients with a mean age of 73. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180982DOI Listing
February 2019

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

We examined the cross-sectional association between mushroom intake and mild cognitive impairment (MCI) using data from 663 participants aged 60 and above from the Diet and Healthy Aging (DaHA) study in Singapore. Compared with participants who consumed mushrooms less than once per week, participants who consumed mushrooms >2 portions per week had reduced odds of having MCI (odds ratio = 0.43, 95% CI 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180959DOI Listing
February 2019

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.

J Alzheimers Dis 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurology, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Type 2 diabetes mellitus (T2DM) increases the risk of vascular cognitive impairment (VCI). It is unknown which type of vascular lesions and co-morbid etiologies, in particular Alzheimer's disease pathology, are associated with T2DM in patients with VCI, and how this relates to cognition and prognosis.

Objective: To compare brain MRI and cerebrospinal fluid (CSF) markers, cognition, and prognosis in patients with possible VCI with and without T2DM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180914DOI Listing
February 2019

Early-Stage Alzheimer's Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA.

Background: Brain insulin resistance is a well-recognized abnormality in Alzheimer's disease (AD) and the likely mediator of impaired glucose utilization that emerges early and progresses with disease severity. Moreover, the rates of mild cognitive impairment (MCI) or AD are significantly greater in people with diabetes mellitus or obesity.

Objective: This study was designed to determine whether systemic and central nervous system (CNS) insulin resistant disease states emerge together and thus may be integrally related. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180906DOI Listing
February 2019

Impaired Glucose Tolerance and Reduced Plasma Insulin Precede Decreased AKT Phosphorylation and GLUT3 Translocation in the Hippocampus of Old 3xTg-AD Mice.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL, USA.

Several studies have demonstrated that mouse models of Alzheimer's disease (AD) can exhibit impaired peripheral glucose tolerance. Further, in the APP/PS1 mouse model, this is observed prior to the appearance of AD-related neuropathology (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180707DOI Listing
February 2019

Polyphenol-enriched azuki bean (Vina angularis) extract reduces the oxidative stress and prevents DNA oxidation in the hearts of streptozotocin-induced early diabetic rats.

Int J Food Sci Nutr 2019 Feb 18:1-11. Epub 2019 Feb 18.

e Faculty of Health Sciences , Hokkaido University , Sapporo , Japan.

We examined the changes in the heart of rats at the early stages of streptozotocin (STZ)-induced diabetes, and whether azuki bean extract (ABE) could influence these changes. The experimental diabetic rats received 0 or 40 mg/kg of ABE orally for 4 weeks, whereas the control group rats received distilled water. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and expression of proteins associated with peroxisomal FA β-oxidation as well as oxidative stress markers were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09637486.2019.1576598DOI Listing
February 2019

Gestational Diabetes Mellitus is Associated with Plasma Amylase in a Chinese Pregnant Women Population.

Clin Lab 2019 Jan;65(1)

Background: The study aimed to investigate the relationship between plasma amylase levels and the endocrine and metabolic biomarkers in Chinese pregnant women with gestational diabetes mellitus (GDM) in the southwest of China and to compare plasma amylase with other known biomarkers in relation to their contributions to identifying GDM, with a view to establishing plasma amylase as an independent laboratory-based risk factor for GDM.

Methods: This study included 1,870 pregnant women divided into three groups: early pregnancy, middle pregnancy, and late pregnancy according to weeks of gestation, and 164 pregnant women were excluded by diseases. Fasting samples of participants were collected and plasma amylase and other metabolic markers were measured. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180550DOI Listing
January 2019

Continued attendance for paediatric weight management: A multicentre, qualitative study of parents' reasons and facilitators.

Clin Obes 2019 Feb 18:e12304. Epub 2019 Feb 18.

Department of Pediatrics, University of Alberta, Edmonton, Canada.

Although prolonged engagement in paediatric weight management (PWM) is associated with positive treatment outcomes, little is currently known about enablers of long-term programme attendance. The purpose of our study was to explore families' reasons for and facilitators of their continued attendance at health services for PWM. Semi-structured, individual interviews were conducted with parents of children (10-17 year old; body mass index ≥85th percentile) who completed the active phase of treatment in one of four Canadian multidisciplinary clinics for PWM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cob.12304DOI Listing
February 2019

Cardiometabolic health in Turner syndrome.

Am J Med Genet C Semin Med Genet 2019 Feb 18. Epub 2019 Feb 18.

Children's Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Blvd., MS #61, Los Angeles, California.

Individuals with Turner syndrome (TS) have a higher morbidity and mortality compared to the general population. Diabetes and cardiovascular disease are the major contributors to this burden. Precursors to diabetes and cardiovascular disease make up what is known as metabolic syndrome, including abdominal obesity, hypertension, dyslipidemia, and elevated fasting glucose. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.c.31678DOI Listing
February 2019

Natural compounds with DPP-4 inhibitory effects: Implications for the treatment of diabetes.

J Cell Biochem 2019 Feb 18. Epub 2019 Feb 18.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetes agents that decrease blood glucose by preventing the degradation of endogenous glucagon-like peptide-1. The first DPP-4 was sitagliptin followed by several other agents in the class introduced to manage diabetes. Recent studies have suggested that naturally occurring compounds can exert an antidiabetes effect through DPP-4 inhibition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.28467DOI Listing
February 2019

The effect of on wound healing of oral mucosa in diabetic rats.

Eur Oral Res 2018 Sep 1;52(3):143-149. Epub 2018 Sep 1.

Department of Oral and Maxillofacial Surgery, Gazi University, Faculty of Dentistry, Ankara, Turkey.

Purpose: This study aims to investigate the histopathological and biochemical effects of the topical application of on the healing of surgical wounds created in the oral mucosa of rats with experimentally induced diabetes mellitus.

Materials And Methods: The study was carried out on 48 adult male Wistar albino rats. The animals were divided into two main groups as control and study groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26650/eor.2018.505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365136PMC
September 2018

The prevalence of infertility in 20-49 years women in Yazd, 2014-2015: A cross-sectional study.

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):683-688

Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Infertility is a serious health problem that affects the individual, her/his family, and the community. Infertility is defined as failure to achieve clinical pregnancy after at least 12 months of unprotected coitus.

Objective: The purpose of this study was to investigate the prevalence of primary and secondary infertility and the associated factors in Yazd Greater Area during 2014-2015. Read More

View Article

Download full-text PDF

Source
November 2018

Racial/Ethnic Trends in Prevalence of Diabetic Kidney Disease in the United States.

Kidney Int Rep 2019 Feb 29;4(2):334-337. Epub 2018 Oct 29.

Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365363PMC
February 2019

Higher Physical Activity Is Associated With Less Fatigue and Insomnia Among Patients on Hemodialysis.

Kidney Int Rep 2019 Feb 1;4(2):285-292. Epub 2018 Nov 1.

Division of Nephrology, University of California, San Francisco, San Francisco, California, USA.

Introduction: Patients on hemodialysis experience a heavy burden of symptoms that may be related to the low levels of physical activity reported in this population. We hypothesized that physical activity would be inversely related to symptom severity and that depression might mediate this association.

Methods: We designed a cross-sectional study of 48 patients receiving hemodialysis at 3 San Francisco dialysis clinics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365400PMC
February 2019

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir With or Without Ribavirin in Patients With Kidney Disease.

Kidney Int Rep 2019 Feb 16;4(2):245-256. Epub 2018 Oct 16.

Mount Sinai Beth Israel, New York, New York, USA.

Introduction: Patients with hepatitis C virus (HCV) infection and chronic kidney disease (CKD) are a high-priority population for treatment.

Methods: We performed a pooled efficacy and safety analysis that included HCV genotype 1-infected patients with compensated liver disease and CKD stages 1 to 3 who received the all-oral 3-direct-acting antiviral regimen of ombitasvir, paritaprevir, ritonavir, and dasabuvir ± ribavirin (OBV/PTV/r + DSV ± RBV) in 11 phase 3 clinical trials. Sustained virologic response rates at posttreatment week 12 (SVR12) and treatment-related adverse events (AEs), serious AEs, and renal-associated AEs are reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365509PMC
February 2019

A randomized controlled trial protocol for people with traumatic brain injury enrolled in a healthy lifestyle program (GLB-TBI).

Contemp Clin Trials Commun 2019 Jun 31;14:100328. Epub 2019 Jan 31.

North Texas Traumatic Brain Injury Model System, USA.

Weight gain is prevalent among people with traumatic brain injury (TBI) and may be attributable to environmental or injury-specific factors such as mobility impairment, endocrine dysfunction, behavioral and emotional disorders, and sensory loss. Few weight management programs exist to meet the unique needs of this population. Researchers modified a nationally recognized, evidence-based weight-loss program, Group Lifestyle Balance™ (GLB), to address the needs of over-weight and obese people post TBI (GLB-TBI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.conctc.2019.100328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365803PMC

Is miRNA-375 a promising biomarker for early detection and monitoring of patients with type 2 diabetes?

Arch Med Sci Atheroscler Dis 2018 8;3:e119-e122. Epub 2018 Oct 8.

Department of Internal Medicine, General Hospital of Veria, Veria, Greece.

miRNAs are small, non-coding RNAs, functioning as negative suppressors of target gene expression. A significant proportion of the transcriptome is subject to miRNA modulation. A single miRNA determines the expression of hundreds of genes, while miRNAs are relatively stable in biological fluids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/amsad.2018.78775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374562PMC
October 2018

Pulse wave velocity and its gender-related associations with cardiovascular risk factors in a high cardiovascular risk population.

Arch Med Sci Atheroscler Dis 2018 3;3:e99-e105. Epub 2018 Jul 3.

Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia.

Introduction: Associations found between pulse wave velocity (PWV) and cardiovascular risk factors (CVrF) are diverse. We aimed to evaluate whether differences in PWV and its associations with CVrF in a high cardiovascular risk population exist between genders and between the whole population (WHgr) and groups of apparently healthy (AHgr) and those of hypertensive, obese or diabetics (Rgr).

Material And Methods: Pulse wave velocity measured by Arteriograph was investigated in 805 adults aged 20-65, randomly selected from the Tallinn Population Register. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/amsad.2018.76919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374584PMC

All-cause mortality of metabolically healthy or unhealthy obese: risk stratification using myocardial perfusion imaging.

Arch Med Sci Atheroscler Dis 2018 28;3:e90-e95. Epub 2018 Jun 28.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Introduction: There is still controversy about the favorable prognosis of "metabolically healthy" (MH) obese. This study evaluated mortality and the use of myocardial perfusion scintigraphy (MPS) for risk stratification of MH or metabolically unhealthy (MU) obese or nonobese patients.

Material And Methods: Patients without dyslipidemia, hypertension, or diabetes were considered MH, and those with ≥ 1 of these risk factors were considered MU. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/amsad.2018.76865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374568PMC

miRNA-122: Can it unravel an alternative pathway in early diagnosis and prognosis of type 2 diabetes mellitus?

Arch Med Sci Atheroscler Dis 2018 28;3:e68-e71. Epub 2018 Jun 28.

Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, General Hospital Hippokration, Thessaloniki, Greece.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/amsad.2018.76823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374563PMC

Prevalence of peripheral arterial disease among diabetic patients in Santo Domingo, Dominican Republic and associated risk factors.

Arch Med Sci Atheroscler Dis 2018 15;3:e35-e40. Epub 2018 Feb 15.

Shanghai Xin Hua Hospital affiliated to the Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Introduction: Peripheral arterial disease (PAD) is a major risk factor of coronary artery disease and a major complication of atherosclerosis. Peripheral arterial disease can be diagnosed with simple and low cost techniques. There are major risk factors of PAD that have been studied for different countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/amsad.2018.73527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374585PMC
February 2018

Acute and sub-acute toxicity of aqueous extract of aerial parts of N. E. Brown in mice and rats.

Heliyon 2019 Jan 29;5(1):e01179. Epub 2019 Jan 29.

Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences College of Health Sciences, University of Ilorin, Kwara State, Nigeria.

N. E. Brown (Asclepiadaceae) is a cactus-like shaped shrub widely used in traditional medicine for the treatment of rheumatoid arthritis, diabetes, infertility and impotence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2019.e01179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356088PMC
January 2019

Association of obesity and sarcopenia among adult Filipinos.

Osteoporos Sarcopenia 2018 Sep 13;4(3):109-113. Epub 2018 Sep 13.

Department of Physiology, College of Medicine, University of the Philippines Manila, Manila, the Philippines.

Objective: Studies on the association of obesity and sarcopenia are conflicting. Some studies showed that obesity is associated with muscle loss and frailty while others showed that lower body mass index (BMI) is associated with increased sarcopenia. To date, there is paucity of data on sarcopenia and obesity among Filipinos. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.afos.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362942PMC
September 2018

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study.

Osteoporos Sarcopenia 2018 Jun 5;4(2):53-60. Epub 2018 May 5.

Institute of Endocrinology, Diabetes and Metabolism, Max Healthcare Inst. Ltd., New Delhi, India.

Objectives: An understanding of bone mineral density (BMD) pattern in a population is crucial for prevention and diagnosis of osteoporosis and management of its complications in later life. This study aimed to screen the bone health status and factors associated with osteoporosis in an apparently healthy Indian population.

Methods: A retrospective review of medical records was done in a tertiary-care hospital for the subjects who had undergone preventive health-check-ups that included BMD measurements at femur-neck, total-femur, and lumbar-spine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.afos.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362954PMC

Comparing Patients with ZZ Versus SZ Alpha-1 Antitrypsin Deficiency: Findings from AlphaNet's Disease Management Program.

Chronic Obstr Pulm Dis 2018 Nov 30;6(1):29-39. Epub 2018 Nov 30.

Division of Pulmonary Sciences and Critical Care Medicine, National Jewish Health, University of Colorado Denver School of Medicine, Denver.

: The aim of this study was to examine differences in demographic, health, and behavioral characteristics in individuals with ZZ and SZ genotypes of alpha-1 antitrypsin deficiency (AATD) within AlphaNet's Disease Management and Prevention Program (ADMAPP). : Self-reported data from 3535 patients with AATD, including 3031 (85.7%) patients with ZZ, ZNull, and NullNull genotypes (referred to here as ZZ), and 504 (14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15326/jcopdf.6.1.2018.0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373591PMC
November 2018
  • Page 1 of 13158