4,320 results match your criteria Developmental and Comparative Immunology [Journal]


γδ T cells are the predominant T cell type in opossum mammaries during lactation.

Dev Comp Immunol 2019 Feb 12. Epub 2019 Feb 12.

Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, 1 University of New Mexico, MSC03-2020, Albuquerque, NM, 87131-1091, USA. Electronic address:

Milk provides mammalian neonates with nutritional support and passive immunity. This is particularly true in marsupials where young are born highly altricial and lacking many components of a fully functional adaptive immune system. Here we investigated the T cell populations in the mammaries of a lactating marsupial, the gray short-tailed opossum Monodelphis domestica. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.005DOI Listing
February 2019

Immunoprofiling of peripheral blood from infectious bronchitis virus vaccinated MHC-B chicken lines - Monocyte MHC-II expression as a potential correlate of protection.

Dev Comp Immunol 2019 Feb 11. Epub 2019 Feb 11.

Department of Animal Science, Aarhus University, Blichers Allé 20, 8830, Tjele, Denmark. Electronic address:

Vaccination programs are implemented in poultry farms to limit outbreaks and spread of infectious bronchitis virus (IBV), which is a substantial economic burden in the poultry industry. Immune correlates, used to predict vaccine efficacy, have proved difficult to find for IBV-vaccine-induced protection. To find correlates of IBV-vaccine-induced protection, hence, we employed a flow cytometric assay to quantify peripheral leucocyte subsets and expression of cell surface markers of six different non-vaccinated and vaccinated Major Histocompatibility Complex (MHC) haplotypes. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.004DOI Listing
February 2019

Expression of avian β-defensin mRNA in the chicken yolk sac.

Dev Comp Immunol 2019 Feb 10;95:89-95. Epub 2019 Feb 10.

Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, 24061, USA. Electronic address:

The chicken yolk sac (YS) plays an important role in nutrient absorption and immune function for the developing embryo. The avian β-defensins (AvBD) are cationic peptides that are important members of the innate immune system. The objective of this study was to profile AvBD mRNA expression patterns and distribution of cells expressing AvBD mRNA in the chicken YS. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.006DOI Listing
February 2019
2.815 Impact Factor

Novel insights into the evolution of the caveolin superfamily and mechanisms of antiapoptotic effects and cell proliferation in lamprey.

Dev Comp Immunol 2019 Feb 8. Epub 2019 Feb 8.

College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China. Electronic address:

Caveolin-1 is the main structural and functional component of caveolin, and it is involved in the regulation of cholesterol transport, endocytosis, and signal transduction. Moreover, changes in caveolin-1 play an important role in tumorigenesis and inflammatory processes. Previous studies have demonstrated that human caveolin-1 is mainly located in the cell membrane and exhibits cell type- and stage-dependent functional differences during cancer development and inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.005DOI Listing
February 2019

Characterization, evolution, and expression analysis of TLR7 gene subfamily members in Mastacembelus armatus (Synbranchiformes: Mastacembelidae).

Dev Comp Immunol 2019 Feb 8;95:77-88. Epub 2019 Feb 8.

State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, PR China. Electronic address:

TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study, we successfully identified 3 members of TLR7 subfamily from the spiny eel Mastacembelus armatus (MaTLR7, MaTLR8 and MaTLR9). The amino acid sequence identities of MaTLR7 and MaTLR8 with Monopterus albus TLR7 were 87. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.002DOI Listing
February 2019

Expression of TCR genes in adult and larval Xenopus laevis.

Dev Comp Immunol 2019 Feb 7. Epub 2019 Feb 7.

Chatham University, Woodland Road, Pittsburgh, PA, 15232, USA. Electronic address:

In order to better understand the development and function of γδ T cells in Xenopus frogs, it is necessary to determine where and when γδ T cells are found in Xenopus tissues. This study examined the expression of TCR genes, focused primarily on TCR γ, in tissues of adult and larval Xenopus laevis and provide new data about the expression pattern of these different TCR genes in this anuran amphibian. TCR gene expression was detected by PCR in adult frog tissues including the thymus, spleen, skin, intestine, lung, and liver, but not the testes. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.007DOI Listing
February 2019

Spp38 MAPK participates in maintaining the homeostasis of hemolymph microbiota in Scylla paramamosain.

Dev Comp Immunol 2019 Feb 6;95:38-49. Epub 2019 Feb 6.

Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou 515063, China; STU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou 515063, China. Electronic address:

The p38 mitogen-activated protein kinases (MAPKs) are evolutionally conserved from yeasts to mammals, and are involved in the regulation of cells response to various extracellular stimuli. In this study, the p38 MAPK gene (designated as Spp38) of mud crab (Scylla paramamosain) was identified and studied. Spp38 contained the conserved Thr-Gly-Tyr (TGY) motif and a Ala-Thr-Arg-Trp (ATRW) substrate-binding site. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.003DOI Listing
February 2019

An in vitro study of NF-κB factors cooperatively in regulation of Drosophila melanogaster antimicrobial peptide genes.

Dev Comp Immunol 2019 Feb 6;95:50-58. Epub 2019 Feb 6.

Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri - Kansas City, Kansas City, MO, 64110, USA; School of Life Sciences, Central China Normal University, Wuhan, 430079, China; Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China; Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China. Electronic address:

An important innate immune response in Drosophila melanogaster is the production of antimicrobial peptides (AMPs). Expression of AMP genes is mediated by the Toll and immune deficiency (IMD) pathways via NF-κB transcription factors Dorsal, DIF and Relish. Dorsal and DIF act downstream of the Toll pathway, whereas Relish acts in the IMD pathway. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.017DOI Listing
February 2019
1 Read

Ingestion of killed bacteria activates antimicrobial peptide genes in Drosophila melanogaster and protects flies from septic infection.

Dev Comp Immunol 2019 Feb 4;95:10-18. Epub 2019 Feb 4.

School of Life Sciences, Central China Normal University, Wuhan, 430079, China; Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Kansas City, MO, 64110, USA. Electronic address:

Drosophila melanogaster possesses a sophisticated and effective immune system composed of humoral and cellular immune responses, and production of antimicrobial peptides (AMPs) is an important defense mechanism. Expression of AMPs is regulated by the Toll and IMD (immune deficiency) pathways. Production of AMPs can be systemic in the fat body or a local event in the midgut and epithelium. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.001DOI Listing
February 2019

20-Hydroxyecdysone regulates the transcription of the lysozyme via Broad-Complex Z2 gene in silkworm, Bombyx mori.

Dev Comp Immunol 2019 May 1;94:66-72. Epub 2019 Feb 1.

State Key Laboratory of Silkworm Genome Biology, Southwest University, 400716, Chongqing, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China; Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400716, Chongqing, China.

Broad-Complex Z2 (Br-C Z2) is an ecdysone inducible transcription factor that regulates physiological, innate immune and developmental events in insects. Here, we identified an orthologue of Br-C Z2 from silkworm, Bombyx mori (BmBr-C Z2) to study its involvement in immune responses. The quantitative real-time PCR analysis revealed that BmBr-C Z2 was expressed ubiquitously in all tested tissues under normal physiological conditions. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.014DOI Listing
May 2019
2.815 Impact Factor

A SPRY domain-containing SOCS box protein 3 (SPSB3) involved in the regulation of cytokine production in granulocytes of Crassostrea gigas.

Dev Comp Immunol 2019 Jan 31;95:28-37. Epub 2019 Jan 31.

Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, 116023, China; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266235, China; Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University, Dalian, 116023, China. Electronic address:

The sp1A/ryanodine receptor (SPRY) family members have been reported to involve in important biological pathways, including innate immune signaling, cytokine signaling suppression, development, cell growth, and retroviral restriction. In the present study, a SPRY domain-containing SOCS box protein (named as CgSPSB3) was identified and characterized from oyster Crassostrea gigas. The open reading frame of CgSPSB3 gene was of 699 bp, encoding a polypeptide of 232 amino acid residues with a central SPRY domain and a C-terminal SOCS box motif. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.013DOI Listing
January 2019

Mitigation of ER-stress and inflammation by chemokine (C-C motif) ligand 21 during early pregnancy.

Dev Comp Immunol 2019 May 31;94:73-84. Epub 2019 Jan 31.

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

The immune system plays an important role in pregnancy. Chemokines recruit leukocytes at the maternal-fetal interface during early pregnancy. However, the role of the chemokine, C-C motif chemokine ligand 21 (CCL21), is less known. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.016DOI Listing

The miR-317 functions as a negative regulator of Toll immune response and influences Drosophila survival.

Dev Comp Immunol 2019 Jan 29;95:19-27. Epub 2019 Jan 29.

Laboratory for Comparative Genomics and Bioinformatics & Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, 210046, China. Electronic address:

The miR-317 has been revealed to involve in the reproductive response and the larval ovary morphogenesis of Drosophila. However, whether the miR-317 can also regulate Drosophila innate immune responses, which remains unclear to date. Here we have verified that miR-317 can directly target the 3'UTR of Dif-Rc to down-regulate the expression levels of AMP Drs to negatively control Drosophila Toll immune response in vivo and vitro. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183042
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http://dx.doi.org/10.1016/j.dci.2019.01.012DOI Listing
January 2019
2 Reads
2.815 Impact Factor

Functional characterization of short-type peptidoglycan recognition proteins (PGRPs) from silkworm Bombyx mori in innate immunity.

Dev Comp Immunol 2019 Jan 30;95:59-67. Epub 2019 Jan 30.

Laboratory of Insect Molecular Biology and Biotechnology, Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

Peptidoglycan recognition proteins (PGRPs) are members of an important class of pattern recognition receptors in insects that can specifically recognize peptidoglycan (PGN) in bacterial cell walls and participate in immune regulation and bacterial clearance. Although the role of PGRPs in regulating the innate immune response in Drosophila melanogaster has been studied, little is known regarding PGRPs in Lepidoptera species. In this study, five short (S)-type Bombyx mori PGRPs (BmPGRPs) were cloned, expressed, and evaluated for their function in innate immunity. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.015DOI Listing
January 2019

Immunometabolism: Insights from the Drosophila model.

Dev Comp Immunol 2019 May 23;94:22-34. Epub 2019 Jan 23.

Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada. Electronic address:

Multicellular organisms inhabit an environment that includes a mix of essential nutrients and large numbers of potentially harmful microbes. Germline-encoded receptors scan the environment for microbe associated molecular patterns, and, upon engagement, activate powerful defenses to protect the host from infection. At the same time, digestive enzymes and transporter molecules sieve through ingested material for building blocks and energy sources necessary for survival, growth, and reproduction. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.011DOI Listing

Tyramine's modulation of immune resistance functions in Litopenaeus vannamei and its signal pathway.

Dev Comp Immunol 2019 Jan 22;95:68-76. Epub 2019 Jan 22.

Department of Aquaculture, National Pingtung University of Science and Technology, Pingtung, 91201, Taiwan. Electronic address:

Tyramine (TA), a neuroactive chemical, plays various important physiological roles in insects by activating distinct G-protein-coupled receptors (GPCRs). In this study, we investigated the effects of by pharmacological injection of TA on immune resistance regulation and its signal pathway in white shrimp Litopenaeus vannamei. Results showed significant increases in the total haemocyte count (THC), semigranular cells (SGCs), granular cells (GCs), phenoloxidase (PO) activity per 50 μL of haemolymph and respiratory bursts (RBs) at 0. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.008DOI Listing
January 2019

Derivatives of the lectin complement pathway in Lophotrochozoa.

Dev Comp Immunol 2019 May 22;94:35-58. Epub 2019 Jan 22.

Sechenov Institute of Evolutionary Physiology and Biochemistry (IEPhB RAS), Saint-Petersburg, Russia. Electronic address:

A plethora of non-overlapping immune molecular mechanisms in metazoans is the most puzzling issue in comparative immunobiology. No valid evolutionary retrospective on these mechanisms has been developed. In this study, we aimed to reveal the origin and evolution of the immune complement-like system in Lophotrochozoa. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183056
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http://dx.doi.org/10.1016/j.dci.2019.01.010DOI Listing
May 2019
7 Reads

Enhanced mucosal immune responses, immune related genes and growth performance in common carp (Cyprinus carpio) juveniles fed dietary Pediococcus acidilactici MA18/5M and raffinose.

Dev Comp Immunol 2019 May 19;94:59-65. Epub 2019 Jan 19.

South Iran Aquaculture Research Centre, Iranian Fisheries Science Institute (IFSRI), Agricultural Research Education and Extension Organization (AREEO), Ahwaz, Iran.

The present study was conducted to evaluate the effects of dietary Pediococcus acidilactici (PA) and raffinose (RF) alone or in combination on growth performance, mucosal immune factors and immune related genes expression in common carp (Cyprinus carpio) juveniles. Fish with initial weight of 10.0 ± 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183058
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http://dx.doi.org/10.1016/j.dci.2019.01.009DOI Listing
May 2019
3 Reads

Teleost antimicrobial peptide hepcidin contributes to host defense of goldfish (Carassius auratus L.) against Trypanosoma carassii.

Dev Comp Immunol 2019 May 17;94:11-15. Epub 2019 Jan 17.

Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Hepcidin is an antimicrobial peptide and an iron regulatory protein that prevents the release of excess iron in the blood. There is evidence suggesting that teleost hepcidin is a major player in antimicrobial defense against various bacteria species, but little is known regarding the effects of teleost hepcidin in protozoan parasitic infections. We examined the role of hepcidin during the course of infection of goldfish with Trypanosoma carassii. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.007DOI Listing
May 2019
1 Read

The transcriptional response of the Pacific oyster Crassostrea gigas under simultaneous bacterial and heat stresses.

Dev Comp Immunol 2019 May 14;94:1-10. Epub 2019 Jan 14.

Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, 52 Heishijiao Street, Dalian, 116023, China. Electronic address:

Bacterial infection and heat stress are considered as two major environmental threats for the aquaculture industry of oyster Crassostrea gigas. In the present study, the expression profiles of mRNA transcripts in the hemocytes of oysters under bacterial challenge and heat stress were examined by next-generation sequencing. There were 21,095, 21,957 and 21,141 transcripts identified in the hemocytes of oysters from three groups, respectively, including control group (designated as Con group), Vibrio splendidus challenge group (Bac group), and bacterial and heat stress combined treatment group (BacHeat group). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183060
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http://dx.doi.org/10.1016/j.dci.2019.01.006DOI Listing
May 2019
4 Reads

Characterization of the ScghC1q-1 gene in Sinonovacula constricta and its role in innate immune responses.

Dev Comp Immunol 2019 May 11;94:16-21. Epub 2019 Jan 11.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, China; Shanghai Engineering Research Center of Aquaculture, Shanghai, 201306, China. Electronic address:

C1q is an important immune gene that can mediate a variety of immune regulatory functions, and is involved in complement pathway activation. In the present study, a ghC1q gene from the razor clam Sinonovacula constricta was identified and named ScghC1q-1. The complete ScghC1q-1 gene is 692 bp in length, with an open reading frame (ORF) of 489 bp encoding a protein of 162 amino acids. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183052
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http://dx.doi.org/10.1016/j.dci.2019.01.004DOI Listing
May 2019
4 Reads
2.815 Impact Factor

Two novel MKKs (MKK4 and MKK7) from Ctenopharyngodon idella are involved in the intestinal immune response to bacterial muramyl dipeptide challenge.

Dev Comp Immunol 2019 04 8;93:103-114. Epub 2019 Jan 8.

Hunan Provincial Key Laboratory of Nutrition and Quality Control of Aquatic Animals, Department of Biological and Environmental Engineering, Changsha University, Changsha, 410022, China; State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, 410081, China. Electronic address:

Mitogen-activated protein kinase kinases (MKKs) are a class of evolutionarily conserved signalling intermediates of the MAPK signalling pathway that can be activated by a diverse range of pathogenic stimuli and are crucial for the regulation of host immune defence. In this study, two fish MKK genes (CiMKK4 and CiMKK7) were first identified and characterized from grass carp (Ctenopharyngodon idella). Similar to other reported MKKs, the present CiMKK4 and CiMKK7 contained a conserved serine/threonine protein kinase (S_TKc) domain and a canonical dual phosphorylation motif. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183058
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http://dx.doi.org/10.1016/j.dci.2019.01.001DOI Listing
April 2019
9 Reads

Immune responses of fish to Ichthyophthirius multifiliis (Ich): A model for understanding immunity against protozoan parasites.

Dev Comp Immunol 2019 04 7;93:93-102. Epub 2019 Jan 7.

Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. Electronic address:

The parasitic ciliate Ichthyophthirius multifiliis (Ich), which infects almost all freshwater fish species, provides an optimal model for the study of immunity against extracellular protozoa. Ich invades the epithelia of mucosal tissues, forms white spots covering the whole body, and induces high mortality, while survivor fish develop both innate and adaptive immunity against Ich attack in systemic and mucosal tissues. Besides the protective roles of the Toll-like receptor (TLR)-mediated innate immune response, the critical immune functions of novel IgT in the skin, gut, gill, and olfactory organ of teleosts have been demonstrated in recent years, and all this information contributes to the ontogeny of the mucosal immune response in vertebrates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183049
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http://dx.doi.org/10.1016/j.dci.2019.01.002DOI Listing
April 2019
9 Reads

Quantitative serum proteomics analyses reveal shrimp responses against WSSV infection.

Dev Comp Immunol 2019 04 7;93:89-92. Epub 2019 Jan 7.

Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China. Electronic address:

For the past decades, quantitative serum proteomics in mammals have been widely applied in biomarker screening. Various serum protein removal methods have been developed to effectively sequester serum abundant proteins. However, few methods have been found for the removal of arthropod serum abundant proteins. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.003DOI Listing
April 2019
1 Read

Investigating the potential immune role of IL-35 in grass carp (Ctenopharyngodon idella).

Dev Comp Immunol 2019 04 24;93:78-88. Epub 2018 Dec 24.

Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; State Key Laboratory of Agricultural Microbiology, College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address:

Interleukin-35 (IL-35) is a member of the IL-12 cytokine family and a heterodimeric protein formed by Epstein-Barr virus-induced gene 3 (EBI3) and IL-12p35. Emerging evidence showed that IL-35 is a key player in the regulation of cellular communication, differentiation, and inflammation. To date, no studies on fish IL-35 have been documented. Read More

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http://dx.doi.org/10.1016/j.dci.2018.12.011DOI Listing
April 2019
1 Read

HcCUB-Lec, a newly identified C-type lectin that contains a distinct CUB domain and participates in the immune defense of the triangle sail mussel Hyriopsis cumingii.

Authors:
Ying Huang Qian Ren

Dev Comp Immunol 2019 04 25;93:66-77. Epub 2018 Dec 25.

Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province, Lianyungang, Jiangsu, 222005, China; College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu, 210023, China. Electronic address:

As pattern recognition receptors (PRRs), C-type lectins (CTLs) play crucial roles in recognizing and eliminating pathogens in innate immunity. In this study, a novel CTL (HcCUB-Lec) was identified from the triangle sail mussel Hyriopsis cumingii. The full-length of HcCUB-Lec cDNA was 1558 bp with an open reading frame of 1281 bp that encodes a putative protein of 426 amino acid residues, including an N-terminal signal peptide, a complement Uegf Bmp1 (CUB) domain, a single carbohydrate recognition domain (CRD), and a transmembrane domain. Read More

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http://dx.doi.org/10.1016/j.dci.2018.12.012DOI Listing
April 2019
1 Read

MicroRNA expression profiling of Plutella xylostella after challenge with B. thuringiensis.

Dev Comp Immunol 2019 04 22;93:115-124. Epub 2018 Dec 22.

College of Agriculture, South China Agricultural University, Laboratory of Bio-Pesticide Innovation and Application of Guangdong Province, Guangzhou, PR China. Electronic address:

The diamondback moth, Plutella xylostella, the main pest of brassica crops, has developed resistance to almost all major classes of insecticides as the farmers rely on insecticides to control this pest. An extensive use of broad-spectrum insecticides against P. xylostella promotes the selection of insecticide resistance, destroy natural enemies, and pollute the environment. Read More

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http://dx.doi.org/10.1016/j.dci.2018.12.008DOI Listing
April 2019
1 Read
2.815 Impact Factor

The Aedes aegypti IMD pathway is a critical component of the mosquito antifungal immune response.

Dev Comp Immunol 2018 Dec 22;95:1-9. Epub 2018 Dec 22.

Crop Bioprotection Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, United States Department of Agriculture, Peoria, IL, USA.

Successful infection of the insect body by entomopathogenic fungi is the result of complex molecular interactions between the host and the invading pathogenic fungi. The mosquito antifungal response is multifaceted and is regulated in part by the Toll and Jak-STAT pathways. Here, we assessed the role of the IMD pathway in the mosquito Ae. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183046
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http://dx.doi.org/10.1016/j.dci.2018.12.010DOI Listing
December 2018
10 Reads

Generation of virus-specific CD8 T cells by vaccination with inactivated virus in the intestine of ginbuna crucian carp.

Dev Comp Immunol 2019 04 21;93:37-44. Epub 2018 Dec 21.

Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, 819-0395, Japan. Electronic address:

Although a previous study using ginbuna crucian carp suggested that cell-mediated immunity can be induced by the oral administration of inactivated viruses, which are exogenous antigens, there is no direct evidence that CD8 cytotoxic T cells (CTLs) in teleost fish are generated by vaccination with exogenous antigens. In the present study, we investigated whether antigen-specific CD8 CTLs in ginbuna crucian carp can be elicited by intestinal immunization with an exogenous antigen without any adjuvant. The IFNγ-1 and T-bet mRNA expressions were up-regulated in intestinal leukocytes following the administration of formalin-inactivated crucian hematopoietic necrosis virus (FI-CHNV), whereas the down-regulation of these genes was observed in kidney leukocytes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183046
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http://dx.doi.org/10.1016/j.dci.2018.12.009DOI Listing
April 2019
6 Reads

Selective breeding for high natural antibody level increases resistance to avian pathogenic Escherichia coli (APEC) in chickens.

Dev Comp Immunol 2019 04 20;93:45-57. Epub 2018 Dec 20.

Wageningen University & Research Adaptation Physiology, Wageningen, The Netherlands.

Keyhole limpet hemocyanin (KLH)-binding natural antibody (NAb) titers in chickens are heritable, and higher levels have previously been associated with a higher survival. This suggests that selective breeding for higher NAb levels might increase survival by means of improved general disease resistance. Chickens were divergently selected and bred for total NAb levels binding KLH at 16 weeks of age for six generations, resulting in a High NAb selection line and a Low NAb selection line. Read More

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http://dx.doi.org/10.1016/j.dci.2018.12.007DOI Listing
April 2019
1 Read

The planarian Schmidtea mediterranea is a new model to study host-pathogen interactions during fungal infections.

Dev Comp Immunol 2019 04 17;93:18-27. Epub 2018 Dec 17.

Department of Molecular & Cell Biology, University of California, Merced, USA; Health Sciences Research Institute, University of California, Merced, USA. Electronic address:

Candida albicans is one of the most common fungal pathogens of humans. Currently, there are limitations in the evaluation of C. albicans infection in existing animal models, especially in terms of understanding the influence of specific infectious stages of the fungal pathogen on the host. Read More

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http://dx.doi.org/10.1016/j.dci.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333478PMC
April 2019
1 Read

Goose MAVS functions in RIG-I-mediated IFN-β signaling activation.

Dev Comp Immunol 2019 04 14;93:58-65. Epub 2018 Dec 14.

Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, PR China. Electronic address:

Mitochondrial antiviral-signaling protein (MAVS) is an essential adaptor protein in retinoic acid-inducible gene I (RIG-I)-mediated antiviral innate immunity in mammals. In this study, the goose MAVS gene (goMAVS) was identified. The 2019 bp-long goMAVS exhibits 96. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183047
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http://dx.doi.org/10.1016/j.dci.2018.12.006DOI Listing
April 2019
9 Reads
2.815 Impact Factor

Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats.

Dev Comp Immunol 2019 04 11;93:1-10. Epub 2018 Dec 11.

Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

Neonatal mammals have increased disease susceptibility and sub-optimal vaccine responses. This raises problems in both humans and farm animals. The high prevalence of paratuberculosis in goats and the lack of an effective vaccine against it have a strong impact on the dairy sector, and calls for vaccines optimized for the neonatal immune system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183042
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http://dx.doi.org/10.1016/j.dci.2018.12.004DOI Listing
April 2019
8 Reads

Molecular characterisation of immunological memory following homologous or heterologous challenges in the schistosomiasis vector snail, Biomphalaria glabrata.

Dev Comp Immunol 2019 03 4;92:238-252. Epub 2018 Dec 4.

Univ. Perpignan Via Domitia, Interactions Hôtes Pathogènes Environments UMR 5244, CNRS, IFREMER, Univ. Montpellier, F-66860, Perpignan, France. Electronic address:

Invertebrate immune response may be primed by a current infection in a sustained manner, leading to the failure of a secondary infection with the same pathogen. The present study focuses on the Schistosomiasis vector snail Biomphalaria glabrata, in which a specific genotype-dependent immunological memory was demonstrated as a shift from a cellular to a humoral immune response. Herein, we investigate the complex molecular bases associated with this genotype-dependant immunological memory response. Read More

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http://dx.doi.org/10.1016/j.dci.2018.12.001DOI Listing
March 2019
3 Reads
2.815 Impact Factor

The role of Bombyx mori Bmtutl-519 protein in the infection of BmN cells by Nosema bombycis.

Dev Comp Immunol 2019 03 6;92:283-290. Epub 2018 Dec 6.

Institute of Sericulture and Apiculture, Yunnan Academy of Agricultural Sciences, Mengzi, 661101, Yunnan, China. Electronic address:

Bmtutl-519 is an isoform of the Bombyx Turtle protein and a member of the immunoglobulin superfamily (IgSF). The relative expression level of Bmtutl-519 was significantly upregulated when BmN cells were infected by Nosema bombycis. The subcellular localization of Bmtutl-519 was studied using an indirect immunoinfluscent assay (IFA), Co-localization assay, Western blotting, and enhanced green fluorescent protein (EGFP) fusion constructs expressed in BmN cells transfected with a Bmtutl-519 expression plasmid. Read More

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http://dx.doi.org/10.1016/j.dci.2018.12.003DOI Listing
March 2019
6 Reads

A Xenopus tadpole alternative model to study innate-like T cell-mediated anti-mycobacterial immunity.

Dev Comp Immunol 2019 03 4;92:253-259. Epub 2018 Dec 4.

Department of Microbiology and Immunology, University of Rochester Medical Center, United States. Electronic address:

Owing to the high incidence of multi-drug resistance and challenges posed by the complex and long duration of treatments, Mycobacterium tuberculosis (Mtb) infections remain a significant clinical burden, which would benefit from development of novel immuno-therapeutic-based treatment strategies. Among early immune effectors, invariant or innate-like (i)T cells are attracting attention because of their potential regulatory activity, which can shape anti-mycobacterial immune responses. Unlike conventional T cells, iT cells express a semi-invariant T cell receptor, and respond rapidly and robustly to molecular patterns presented by MHC class I-like molecules. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183047
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http://dx.doi.org/10.1016/j.dci.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330235PMC
March 2019
6 Reads

Imaging flow cytometry and confocal microscopy-based examination of F-actin and phosphoinositide dynamics during leukocyte immune-type receptor-mediated phagocytic events.

Dev Comp Immunol 2019 03 30;92:199-211. Epub 2018 Nov 30.

Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Cells of the innate immune system rapidly detect and eliminate invading microbes using surface-expressed immunoregulatory receptors that translate extracellular binding events into potent effector responses. Channel catfish (Ictalurus punctatus) leukocyte immune-type receptors (IpLITRs) are a family of immunoregulatory proteins that have been shown to regulate several innate immune cell effector responses including the phagocytic process. The mechanisms by which these receptors regulate phagocytosis are not entirely understood but we have previously shown that different IpLITR-types use ITAM-dependent as well as ITAM-independent pathways for controlling target engulfment. Read More

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http://dx.doi.org/10.1016/j.dci.2018.11.018DOI Listing
March 2019
2 Reads

From the raw bar to the bench: Bivalves as models for human health.

Dev Comp Immunol 2019 03 29;92:260-282. Epub 2018 Nov 29.

Pacific Northwest Research Institute, Seattle, WA, 98122, USA.

Bivalves, from raw oysters to steamed clams, are popular choices among seafood lovers and once limited to the coastal areas. The rapid growth of the aquaculture industry and improvement in the preservation and transport of seafood have enabled them to be readily available anywhere in the world. Over the years, oysters, mussels, scallops, and clams have been the focus of research for improving the production, managing resources, and investigating basic biological and ecological questions. Read More

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http://dx.doi.org/10.1016/j.dci.2018.11.020DOI Listing
March 2019
2 Reads
2.815 Impact Factor

VEGF-like protein from Apostichopus japonicus promotes cell proliferation and migration.

Dev Comp Immunol 2019 03 2;92:230-237. Epub 2018 Dec 2.

School of Marine Sciences, Ningbo University, Ningbo, 315211, PR China.

Vascular endothelial growth factor (VEGF) is a key conservative regulator of inflammation response by promoting cell proliferation, migration, and vascular permeability. It also induces the release of inflammatory factors in vertebrates. We previously characterized NLR family pyrin domain containing 3 and HMGB3 homology in Apostichopus japonicus, providing the occurrence of inflammation in this species. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183048
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http://dx.doi.org/10.1016/j.dci.2018.11.017DOI Listing
March 2019
10 Reads

Comparative models for human nasal infections and immunity.

Dev Comp Immunol 2019 03 1;92:212-222. Epub 2018 Dec 1.

University of New Mexico, Department of Biology, Center for Evolutionary and Theoretical Immunology (CETI), Albuquerque, NM, USA.

The human olfactory system is a mucosal surface and a major portal of entry for respiratory and neurotropic pathogens into the body. Understanding how the human nasopharynx-associated lymphoid tissue (NALT) halts the progression of pathogens into the lower respiratory tract or the central nervous system is key for developing effective cures. Although traditionally mice have been used as the gold-standard model for the study of human nasal diseases, mouse models present important caveats due to major anatomical and functional differences of the human and murine olfactory system and NALT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183049
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http://dx.doi.org/10.1016/j.dci.2018.11.022DOI Listing
March 2019
13 Reads

The degree of postpartum metabolic challenge in dairy cows is associated with peripheral blood mononuclear cell transcriptome changes of the innate immune system.

Dev Comp Immunol 2019 04 27;93:28-36. Epub 2018 Nov 27.

RNA Sequencing Core, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

Dairy cows undergo a nutrient deficit immediately postpartum when lactational demands exceed nutrient intake. This occurs concurrently to an increased challenge due to bacterial and viral infections, yet ability for pathogen clearance is reduced despite a heightened and often host-damaging inflammatory response. We hypothesized that nutrient stress is associated with differences in the immune cell transcriptome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183040
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http://dx.doi.org/10.1016/j.dci.2018.11.021DOI Listing
April 2019
6 Reads

A comparative global proteomic analysis of the hematopoietic lineages in the crustacean Pacifastacus leniusculus.

Dev Comp Immunol 2019 03 24;92:170-178. Epub 2018 Nov 24.

Department of Comparative Physiology, Uppsala University, Norbyvägen 18A, 752 36, Uppsala, Sweden.

In crustaceans as in other arthropods, the circulating hemocytes are vital for protecting the animal against attacking microorganisms. As many hemocytes are destroyed early during an infection, new hemocytes must fast get in place to prevent disperse of a pathogenic microbe, In order to understand the hematopoietic process in more detail we here report a complete proteomic analysis from purified cell types from the APC of the hematopoietic tissue, via the remaining parts of the HPT to the mature semigranular and granular hemocytes. Several possible cell type specific proteins are detected and new putative biomarkers within the crayfish hematopoietic lineage that can be used to increase the understanding of how the differentiation process is regulated is described. Read More

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http://dx.doi.org/10.1016/j.dci.2018.11.016DOI Listing
March 2019
2 Reads

Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues.

Dev Comp Immunol 2019 03 24;92:160-169. Epub 2018 Nov 24.

Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Box 596, SE-751 24, Uppsala, Sweden. Electronic address:

Serine proteases constitute the major protein content of mammalian mast cell granules and the selectivity for substrates by these proteases is of major importance for the role of mast cells in immunity. In order to address this subject, we present here the extended cleavage specificity of sheep mast cell protease-2 (MCP2), a chymotrypsin-type serine protease. Comparison of the extended specificity results to a panel of mammalian mast cell chymases show, in almost all aspects, the same cleavage characteristics. Read More

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http://dx.doi.org/10.1016/j.dci.2018.11.019DOI Listing
March 2019
2 Reads

Phosphoenolpyruvate carboxykinase is involved in antiviral immunity against Bombyx mori nucleopolyhedrovirus.

Dev Comp Immunol 2019 03 22;92:193-198. Epub 2018 Nov 22.

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, 400715, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing, 400715, China. Electronic address:

Phosphoenolpyruvate carboxykinase (PEPCK) has cytoplasmic isoform (PEPCK-C) and a mitochondrial isoform (PEPCK-M). PEPCK-C plays an important role in gluconeogenesis, but the function of PEPCK-M is largely unknown. In this study, we cloned two isoforms of PEPCK (BmPEPCK-1 and BmPEPCK-2; both of PEPCK-M) from the lepidopteran model Bombyx mori. Read More

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http://dx.doi.org/10.1016/j.dci.2018.11.015DOI Listing
March 2019
2 Reads

A secreted-Cu/Zn superoxide dismutase from Microplitis bicoloratus reduces reactive oxygen species triggered by symbiotic bracovirus.

Dev Comp Immunol 2019 03 22;92:129-139. Epub 2018 Nov 22.

School of Life Sciences, Yunnan University, Kunming, 650500, PR China; Key Laboratory of the University in Yunnan Province for International Cooperation in Intercellular Communications and Regulations, Yunnan University, Kunming, 650500, PR China; Biocontrol Engineering Research Centre of Crop Disease & Pest in Yunnan Province, Kunming, 650500, PR China; Key Laboratory for Biochemistry and Molecular Biology, PR China; Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, Yunnan University, Kunming, 650500, PR China. Electronic address:

In the parasitoid/polydnavirus/host system, polydnaviruses protect larva development in the host hemocoel by suppressing the host immune response. However, the negative effects on the parasitoid and the strategy of the parasitoid to deal with this disadvantage are still unknown. Microplitis bicoloratus bracovirus induces granulocyte apoptosis to suppress immune responses, resulting in an apoptotic haemolymph environment in which immature M. Read More

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http://dx.doi.org/10.1016/j.dci.2018.11.014DOI Listing
March 2019
13 Reads
2.820 Impact Factor

A novel LRR-only protein mediates bacterial proliferation in hemolymph through regulating expression of antimicrobial peptides in mollusk Chlamys farreri.

Dev Comp Immunol 2019 03 20;92:223-229. Epub 2018 Nov 20.

CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China; Laboratory for Marine Biology and Biotechnology, National Laboratory for Marine Science and Technology, Qingdao, 266237, China; CAS Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266400, China. Electronic address:

Leucine-rich repeat (LRR)-only proteins are involved in innate immune responses through mediating protein-ligand or protein-protein interactions, yet the exact roles of most LRR-only proteins in invertebrates are not well documented. In the present study, a novel LRR-only protein (designated CfLRRop-7) was identified in Zhikong scallop Chlamys farreri. The full-length cDNA sequence of CfLRRop-7 was 1463 bp and contained an open reading frame of 1086 bp, which encoded a protein of 361 amino acids. Read More

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http://dx.doi.org/10.1016/j.dci.2018.11.013DOI Listing
March 2019
23 Reads

Anti-inflammatory effects of Ang-(1-7) via TLR4-mediated inhibition of the JNK/FoxO1 pathway in lipopolysaccharide-stimulated RAW264.7 cells.

Dev Comp Immunol 2019 03 17;92:291-298. Epub 2018 Nov 17.

Department of Rheumatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address:

Targeting inflammation is considered a challenging pharmacological strategy to prevent or delay the development of inflammatory diseases, such as severe asthma, Crohn's disease, and rheumatoid arthritis. The angiotensin-(1-7) -Mas axis ((Ang-(1-7)-Mas axis) was confirmed to antagonize the effects of the Angiotensin II-AT receptor axis and the latter is reported to regulate cardiovascular and renal function, as well as contribute to the inflammatory process. In this paper, we aim to explore the crucial effect of Ang-(1-7) in inflammation and disclose the mechanisms in lipopolysaccharide (LPS)-induced murine macrophages RAW264. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183009
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http://dx.doi.org/10.1016/j.dci.2018.11.009DOI Listing
March 2019
6 Reads

Roles of polymorphic cathelicidins in innate immunity of soft-shell turtle, Pelodiscus sinensis.

Dev Comp Immunol 2019 03 16;92:179-192. Epub 2018 Nov 16.

School of Life Science and Biotechnology, Dalian University of Technology, Dalian, Liaoning, 116024, China. Electronic address:

Cathelicidins are a class of gene-encoded immune effectors in vertebrate innate immune system. Though being extensively studied in mammals, little is known about the roles of cathelicidins in turtles, the water-dwelling vertebrates in the order Testudines. In the present study, six novel cathelicidins (Ps-CATH1-6) with different tissue and inducible expression patterns were characterized from the turtle of economic importance, Chinese soft-shell turtle (Pelodiscus sinensis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183046
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http://dx.doi.org/10.1016/j.dci.2018.11.010DOI Listing
March 2019
10 Reads

Class A scavenger receptors mediate extracellular dsRNA sensing, leading to downstream antiviral gene expression in a novel American toad cell line, BufoTad.

Dev Comp Immunol 2019 03 16;92:140-149. Epub 2018 Nov 16.

Department of Health Sciences, Wilfrid Laurier University, Waterloo, ON, Canada; Department of Biology, Wilfrid Laurier University, Waterloo, ON, Canada. Electronic address:

Viral double-stranded (ds)RNA is a potent pathogen-associated molecular pattern (PAMP), capable of inducing a strong antiviral state within the cell, protecting the cell from virus infection. In mammals and fish, sensing extracellular dsRNA is mediated by cell-surface class A scavenger receptors (SR-As). Currently, very little is known about SR-As in amphibians, including: sequence, expression patterns and function. Read More

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http://dx.doi.org/10.1016/j.dci.2018.11.012DOI Listing
March 2019
11 Reads

A β-defensin gene of Trachinotus ovatus might be involved in the antimicrobial and antiviral immune response.

Dev Comp Immunol 2019 03 15;92:105-115. Epub 2018 Nov 15.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, PR China; Key Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, PR China.

Defensins are a group of small cationic and cysteine-rich peptides that are important components of the innate immune system. However, studies on defensins in teleosts are very limited, particularly studies on defensin functions through in vivo assays. In this study, we cloned and identified one β-defensin (TroBD) the golden pompano, Trachinotus ovatus, and analyzed the functions of TroBD in both in vivo and in vitro assays. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183046
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http://dx.doi.org/10.1016/j.dci.2018.11.011DOI Listing
March 2019
10 Reads