4,360 results match your criteria Developmental and Comparative Immunology [Journal]


Title: The innate immune system of kissing bugs, vectors of chagas disease.

Dev Comp Immunol 2019 Apr 20. Epub 2019 Apr 20.

Department of Biological Sciences, Simon Fraser University, 8888 University Dr., Burnaby, V5A 1S6, BC, Canada. Electronic address:

Kissing bugs have long served as models to study many aspects of insect physiology. They also serve as vectors for the parasite Trypanosoma cruzi that causes Chagas disease in humans. The overall success of insects is due, in part, to their ability to recognize parasites and pathogens as non-self and to eliminate them using their innate immune system. Read More

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http://dx.doi.org/10.1016/j.dci.2019.04.007DOI Listing

Immunity of Fleas (Order Siphonaptera).

Authors:
Lisa D Brown

Dev Comp Immunol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biology, Georgia Southern University, P.O. Box 8042-1, Statesboro, GA, 30460, USA. Electronic address:

The immune response of arthropod vectors plays a key role in the spread and transmission of vector-borne diseases. Although fleas transmit several human pathogens (e.g. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.019DOI Listing

The RAG2 gene of yellow catfish (Tachysurus fulvidraco) and its immune response against Edwardsiella ictaluri infection.

Dev Comp Immunol 2019 Apr 16. Epub 2019 Apr 16.

Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, China. Electronic address:

Recombination-activating gene 2 (rag 2) allies with recombination-activating gene 1 (rag 1) and regulates the V(D)J recombination of immunoglobulin (Ig) and T-cell receptor (TCR) genes. Being a key player in the adaptive immune response of vertebrates, functional characterization of rag 2 from yellow catfish is beneficial for understanding the biological response towards the pathogens. In this report, we have cloned and characterized the rag 2 gene of yellow catfish, and a particular pattern of expression was analysed in the major tissues of yellow catfish. Read More

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http://dx.doi.org/10.1016/j.dci.2019.04.006DOI Listing

Hemolymph C1qDC promotes the phagocytosis of oyster Crassostrea gigas hemocytes by interacting with the membrane receptor β-integrin.

Dev Comp Immunol 2019 Apr 14;98:42-53. Epub 2019 Apr 14.

Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266235, China; Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian, 116023, China; Liaoning Key Laboratory of Marine Animal Immunology and Disease Control, Dalian Ocean University, Dalian, 116023, China. Electronic address:

Phagocytosis constitutes a conserved cellular process for multicellular animals to ingest or engulf other cells or particles, which is facilitated by the use of opsonins to bind foreign particles and interact with cell surface receptors. The invertebrate secreted C1q domain-containing proteins (C1qDCs) have been reported to exhibit opsonic activity, while the detailed mechanisms of opsonization still remain unclear. In the present study, a C1qDC (designated as CgC1qDC-5) with opsonic activity was identified from the hemolymph of oyster Crassostrea gigas. Read More

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http://dx.doi.org/10.1016/j.dci.2019.04.004DOI Listing

Galectin-1 Induces Immune Response and Antiviral Ability in Cherry Valley Ducks After Duck Plague Virus Infection.

Dev Comp Immunol 2019 Apr 12. Epub 2019 Apr 12.

College of Animal Science and Veterinary Medicine, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin of Shandong Province, Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province, 271018, China; Collaborative Innovation Centre for the Origin and Control of Emerging Infectious Diseases of Taishan Medical College, Tai'an City, 271000, Shandong Province, China. Electronic address:

Galectin-1, as a typical animal galactose-binding protein, it is found on the cell surface and in the extracellular matrix. Cloning the full-length coding sequence of galectin-1 from the spleens of Cherry Valley ducks revealed that the coding sequence of duck galectin-1 (duGal-1) comprises 405 bp, encoding 134 amino acids. Homologic analysis revealed its amino acid sequence is most identical to that of Anas platyrhynchos (98. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183056
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http://dx.doi.org/10.1016/j.dci.2019.04.005DOI Listing
April 2019
6 Reads

Molecular characterization, expression and antimicrobial activities of a c-type lysozyme from the mud crab, Scylla paramamosain.

Dev Comp Immunol 2019 Apr 13;98:54-64. Epub 2019 Apr 13.

Key Laboratory of Aquatic Product Processing, Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, Guangdong, 510300, PR China; Shanghai Ocean University, Shanghai, 201206, PR China. Electronic address:

Lysozyme is an important immune protein involved in the first line of defense for crustaceans. In the present study, a c-type lysozyme gene (SpLyzC) was cloned and characterized from the mud crab, Scylla paramamosain. The full-length cDNA was 849 bp with an open reading frame of 669 bp, and encoded a polypeptide of 223 amino acids with a calculated molecular mass of 23. Read More

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http://dx.doi.org/10.1016/j.dci.2019.04.002DOI Listing

Molecular and functional characterization of a short-type peptidoglycan recognition protein, PGRP-S in the amphibian Xenopus laevis.

Dev Comp Immunol 2019 Apr 10;98:13-19. Epub 2019 Apr 10.

State Key Laboratory of Freshwater Ecology and Biotechnology, Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province, 430072, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province, 266237, China; School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China. Electronic address:

Peptidoglycan recognition proteins (PGRPs) are a family of pattern recognition receptors (PRRs) involved in host antibacterial responses, and their functions have been characterized in most invertebrate and vertebrate animals. However, little information is available regarding the function of frog PGRPs. In this study, a short-type PGRP (termed Xl-PGRP-S) gene was identified in the African clawed frog, Xenopus laevis. Read More

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http://dx.doi.org/10.1016/j.dci.2019.04.003DOI Listing

The regulatory actions of retinoic acid on M2 polarization of porcine macrophages.

Dev Comp Immunol 2019 Apr 8;98:20-33. Epub 2019 Apr 8.

U.S. Department of Agriculture - Agriculture Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics and Immunology Laboratory, Beltsville, MD, 20705, USA. Electronic address:

We previously demonstrated that the most bioactive vitamin A metabolite, all-trans retinoic acid (ATRA), increased T helper 2-associated responses induced in pigs by infection with the parasitic nematode Ascaris suum We also showed that ATRA potentiated the mRNA expression of several IL-4 induced chemokines (chemokine (CC motif) ligand 11 [(CCL11), CCL17, CCL22 and CCL26] associated with alternative activation (M2a) in porcine macrophages in vitro. Herein, several mechanisms whereby ATRA affects IL-4 signaling are profiled using large-scale real time PCR and RNA-Seq analysis. Twenty-three genes associated with M2a markers in other species were independently upregulated by both IL-4 and ATRA, including the adenosine receptor A2B (ADORA2B), cysteinyl leukotriene receptor 2 (CYSLTR2) and the vitamin D receptor (VDR). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183049
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http://dx.doi.org/10.1016/j.dci.2019.03.020DOI Listing
April 2019
5 Reads

Spry is downregulated by multiple viruses to elevate ERK signaling and ensure viral reproduction in silkworm.

Dev Comp Immunol 2019 Apr 6;98:1-5. Epub 2019 Apr 6.

Biological Science Research Center, Southwest University, Chongqing, 400716, China; Chongqing Key Laboratory of Sericultural Science, Chongqing, 400716, China; Chongqing Engineering and Technology Research Center for Novel Silk Materials, Chongqing, 400716, China. Electronic address:

Viral diseases of silkworm are mainly caused by Bombyx mori nucleopolyhedrovirus (BmNPV), B. mori cytoplasmic polyhedrosis virus (BmCPV) and B. mori bidensovirus (BmBDV). Read More

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http://dx.doi.org/10.1016/j.dci.2019.04.001DOI Listing

Models of human psoriasis: Zebrafish the newly appointed player.

Dev Comp Immunol 2019 Apr 4;97:76-87. Epub 2019 Apr 4.

Faculty of Biosciences and Aquaculture, Nord University, Bodø, Norway. Electronic address:

Psoriasis is a human chronic, immune disease with severe cutaneous and systemic manifestations. Its prevalence, among the world population, highly varies with ethnicity and geography, but not sex from remarkable low levels in Asia to 2.3% in Spain, or an impressive 11. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.018DOI Listing
April 2019
1 Read

Functional characterization of IL-10 and its receptor subunits in a perciform fish, the mandarin fish, Siniperca chuatsi.

Dev Comp Immunol 2019 Mar 29;97:64-75. Epub 2019 Mar 29.

State Key Laboratory of Freshwater Ecology and Biotechnology, and Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province, 430072, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province, 266237, China; School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China. Electronic address:

Interleukin (IL)-10 is an immune-regulatory cytokine with multiple functions. In the current study, IL-10 and its two receptors, IL-10R1 and IL-10R2 were identified in mandarin fish, Siniperca chuatsi. The inhibitory effect of mandarin fish IL-10 was investigated on pro-inflammatory cytokine expression and the ligand-receptor relationship. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.017DOI Listing
March 2019
2 Reads
2.815 Impact Factor

Full characterization and transcript expression profiling of the interferon regulatory factor (IRF) gene family in Atlantic cod (Gadus morhua).

Dev Comp Immunol 2019 Mar 27. Epub 2019 Mar 27.

Department of Ocean Sciences, Memorial University of Newfoundland, NL, A1C 5S7, Canada. Electronic address:

Atlantic cod (Gadus morhua) represents a unique immune system among teleost fish, making it a species of interest for immunological studies, and especially for investigating the evolutionary history of immune gene families. The interferon regulatory factor (IRF) gene family encodes transcription factors which function in the interferon pathway, but also in areas including leukocyte differentiation, cell growth, autoimmunity, and development. We previously characterized several IRF family members in Atlantic cod (Irf4a, Irf4b, Irf7, Irf8, and two Irf10 splice variants) at the cDNA and putative amino acid levels, and in the current study we took advantage of the new and improved Atlantic cod genome assembly in combination with rapid amplification of cDNA ends (RACE) to characterize the remaining family members (i. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.015DOI Listing
March 2019
1 Read

Receptor complex and signalling pathway of the two type II IFNs, IFN-γ and IFN-γrel in mandarin fish or the so-called Chinese perch Siniperca chuatsi.

Dev Comp Immunol 2019 Mar 25;97:98-112. Epub 2019 Mar 25.

State Key Laboratory of Freshwater Ecology and Biotechnology, and Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province, 430072, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province, 266237, China; School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China. Electronic address:

IFN-γ, as the sole member of mammalian type II IFN, is a multifunctional cytokine which exerts its effects through two distinct IFN-γ receptors, IFNGR1 and IFNGR2. However, in teleost fish, another IFN-γ homologous gene, namely IFN-γ related gene (IFN-γrel), has been identified. Although IFN-γ and IFN-γrel genes have been described in some fish species, many important aspects remain poorly understood in relation with their signalling and function. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.016DOI Listing
March 2019
2.815 Impact Factor

An IMD-like pathway mediates the intestinal immunity to modulate the homeostasis of gut microbiota in Rhynchophorus ferrugineus Olivier (Coleoptera: Dryophthoridae).

Dev Comp Immunol 2019 Mar 23;97:20-27. Epub 2019 Mar 23.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Insect Ecology, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address:

Most animals have established the mutualistic interactions with their intestinal microbes which provide multiple benefits to their host physiology. However, the mechanisms behind hosts determine the load and composition of gut microbiota are still poorly understood outside dipteran insects. Here, the gene, encoding the NF-κB-like transcription factor Relish, being designated as RfRelish, was identified and analyzed in red palm weevil (RPW), Rhynchophorus ferrugineus Olivier. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.013DOI Listing

An E3 ubiquitin ligase TRIM9 is involved in WSSV infection via interaction with β-TrCP.

Dev Comp Immunol 2019 Mar 22;97:57-63. Epub 2019 Mar 22.

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, 266071, China. Electronic address:

The TRIpartite Motif (TRIM) proteins are known to play key roles in cell differentiation, apoptosis, development, autophagy and innate immunity. In the present study, a TRIM9 homolog (named LvTRIM9) was identified from the transcriptome of the Pacific whiteleg shrimp Litopenaeus vannamei. The deduced amino acid sequence of LvTRIM9 possessed typical features of TRIMs, consisting of a RING domain, two B-boxes, a coiled-coil domain, a FN3 domain, and a SPRY domain. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.014DOI Listing

Chronic inflammation is a key to inducing liver injury in blunt snout bream (Megalobrama amblycephala) fed with high-fat diet.

Dev Comp Immunol 2019 Mar 22;97:28-37. Epub 2019 Mar 22.

Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang Road, Nanjing, 210095, Jiangsu Province, People's Republic of China. Electronic address:

The aim of this article is to investigate the mechanism of lipotoxicity induced by high-fat diets (HFD) in Megalobrama amblycephala. In the present study, fish (average initial weight 40.0 ± 0. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.009DOI Listing

FOXO genes in channel catfish and their response after bacterial infection.

Dev Comp Immunol 2019 Mar 21;97:38-44. Epub 2019 Mar 21.

Department of Biology, College of Art and Sciences, Syracuse University, Syracuse, NY, 13244, USA. Electronic address:

FOXO proteins are a subgroup of the forkhead family of transcription factors that play crucial roles in lifespan regulation. In addition, FOXO proteins are also involved in immune responses. After a systematic study of FOXO genes in channel catfish, Ictalurus punctatus, seven FOXO genes were identified and characterized, including FOXO1a, FOXO1b, FOXO3a, FOXO3b, FOXO4, FOXO6a and FOXO6b. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X193003
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http://dx.doi.org/10.1016/j.dci.2019.03.010DOI Listing
March 2019
6 Reads

Grass carp (Ctenopharyngodon idella) RSK2 protects cells anti-apoptosis by up-regulating BCL-2.

Dev Comp Immunol 2019 Mar 21;97:45-56. Epub 2019 Mar 21.

College of Life Science, Nanchang University, Poyang Lake Key Laboratory of Environment and Resource Utilization, Ministry of Education, Nanchang University, Nanchang, 330031, China. Electronic address:

In mammals, toll-like receptor 3 (TLR3) is capable of recognizing double-stranded RNA and then initiates transcription of IFN-β. TLR3 can activate the innate immune system by phosphorylating extracellular signal-regulated kinase 1 (ERK1) in the mitogen-activated protein kinase (MAPK) pathway. As a downstream signaling protein of ERK1, ribosomal protein S6 kinase alpha 3 (RSK2) is activated through the "classical" MAPK pathway. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183062
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http://dx.doi.org/10.1016/j.dci.2019.03.011DOI Listing
March 2019
3 Reads

Identification and expression analysis of 19 CC chemokine genes in orange-spotted grouper (Epinephelus coioides).

Dev Comp Immunol 2019 Mar 20;97:1-10. Epub 2019 Mar 20.

Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung, Taiwan, ROC; Department of Aquaculture, National Taiwan Ocean University, Keelung, Taiwan, ROC.

In this study, we describe 19 different CC chemokine genes from the orange-spotted grouper, Epinephelus coioides, identified by the analysis of the spleen transcriptome. Multiple sequence alignment of the 19 CC chemokines showed that although two genes, EcSCYA115 and EcSCYA117, shared 80% amino acid similarity (72% identity), the majority exhibited low similarity to each other. Phylogenetic analysis divided the 19 CC chemokines into six major groups. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.006DOI Listing

A novel invertebrate toll-like receptor is involved in TLR mediated signal pathway of thick shell mussel Mytilus coruscus.

Dev Comp Immunol 2019 Mar 20;97:11-19. Epub 2019 Mar 20.

National Engineering Research Center of Marine Facilities Aquaculture, Zhejiang Ocean University, Zhejiang, Zhoushan, 316004, China. Electronic address:

Toll-like receptors (TLRs) are the most well studied pattern recognition receptors (PRRs) that play a crucial role in both innate and adaptive immunity in animals. In the present study, a novel toll-like receptor (McTLRj) was identified and characterised in thick shell mussel Mytilus coruscus. McTLRj possessed a signal peptide, a transmembrane domain, leucine-rich repeats and an intracellular Toll/interleukin-1 receptor domain that were conserved in typical TLRs. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.012DOI Listing

Functional characterization of interleukin (IL)-22 and its inhibitor, IL-22 binding protein (IL-22BP) in Mandarin fish, Siniperca chuatsi.

Dev Comp Immunol 2019 Mar 19;97:88-97. Epub 2019 Mar 19.

State Key Laboratory of Freshwater Ecology and Biotechnology, and Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province, 430072, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province, 266237, China; School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China. Electronic address:

As an important immune regulatory molecule, interleukin (IL)-22 has been reported in several species of fish, but its soluble receptor, IL-22 binding protein (IL-22BP), discovered as a natural antagonist of IL-22 in mammals, has not been functionally characterized in fish to date. In the present study, IL-22 and IL-22BP genes were cloned in mandarin fish Siniperca chuatsi. They all exhibited a high basal expression level in mucosa-enriched tissues, implying their possible roles in mucosal immunity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X193008
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http://dx.doi.org/10.1016/j.dci.2019.03.007DOI Listing
March 2019
4 Reads
2.815 Impact Factor

Overexpression of Gloverin2 in the Bombyx mori silk gland enhances cocoon/silk antimicrobial activity.

Dev Comp Immunol 2019 Mar 18;98:6-12. Epub 2019 Mar 18.

Biological Science Research Center, Southwest University, Chongqing, 400716, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing, 400715, China. Electronic address:

The Bombyx mori cocoon/silk possesses many immune-related components, including protease inhibitors, seroins, and antimicrobial peptides, which likely help to protect the pupating larva from infection. However, the natural antimicrobial activity of the B. mori cocoon/silk is still too weak for biomedical applications. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.008DOI Listing
March 2019
2.815 Impact Factor

The negative regulation of piscine CD44c in viral and bacterial infection.

Dev Comp Immunol 2019 Jul 15;96:135-143. Epub 2019 Mar 15.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province, 430072, China; Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Wuhan, Hubei Province, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address:

CD44 gene is a cell surface receptor which undergoes complex alternative splicing and extensive post-translational modifications. Although many studies have showed that CD44 is involved in the process of host defense, the function of piscine CD44 in antibacterial or antiviral defense response remains unclear. In the present study, we report the functional characterization of zebrafish CD44c, which is more similar to CD44b antigen isoforms rather than CD44a based on amino acid composition and phylogenetic analysis. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.005DOI Listing

Mendelian inheritance of endogenous viral elements (EVE) of white spot syndrome virus (WSSV) in shrimp.

Dev Comp Immunol 2019 Jul 12;96:144-149. Epub 2019 Mar 12.

National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Paholyothin Rd, Khlong Luang, Pathum Thani, 12120, Thailand; Center for Excellence in Shrimp Molecular Biology and Biotechnology (Centex Shrimp), Faculty of Science, Mahidol University, Rama VI Rd, Phayathai, Bangkok, 10400, Thailand. Electronic address:

Previous work has shown that non-retroviral endogenous viral elements (EVE) are common in crustaceans, including penaeid shrimp. So far, they have been reported for infectious hypodermal and hematopoietic necrosis virus (IHHNV) and white spot syndrome virus (WSSV). For the latter, it was shown that shrimp sperm were positive for an EVE of WSSV called EVE, suggesting that it was heritable, since shrimp sperm (non-motile) do not contain mitochondria. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X193001
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http://dx.doi.org/10.1016/j.dci.2019.03.004DOI Listing
July 2019
2 Reads

Temperature regulates the recognition activities of a galectin to pathogen and symbiont in the scleractinian coral Pocillopora damicornis.

Dev Comp Immunol 2019 Jul 8;96:103-110. Epub 2019 Mar 8.

Key Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, Haikou, 570228, China.

Lectins serve as essential pattern recognition receptors, and play important roles in the recognition of non-self and mediation of innate immune response in metazoans. Scleractinian corals are vulnerable to pathogen infection and endosymbiosis disruption under heat stress that can finally lead to coral bleaching. In this study, a cDNA sequence encoding one galectin was cloned in scleractinian coral Pocillopora damicornis (PdGLT-1). Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.003DOI Listing
July 2019
2 Reads

Association of MHC IIA polymorphisms with disease resistance in Aeromonas hydrophila-challenged Nile tilapia.

Dev Comp Immunol 2019 Jul 7;96:126-134. Epub 2019 Mar 7.

Department of Chemistry (Biochemistry Branch), Faculty of Science, Tanta University, Egypt.

The major histocompatibility complex (MHC) genes show high polymorphisms in vertebrates depending on animal immunity status. Herein, MHC class IIA gene in Aeromonas hydrophila-challenged Nile tilapia was screened for presence of polymorphisms using sequencing. Twelve nucleotides deletion polymorphism was determined with a PCR product size of 267 bp in the resistant fish and 255 bp in the control and susceptible/diseased fish. Read More

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http://dx.doi.org/10.1016/j.dci.2019.03.002DOI Listing
July 2019
2 Reads

NLRX1 of black carp suppresses MAVS-mediated antiviral signaling through its NACHT domain.

Dev Comp Immunol 2019 Jul 7;96:68-77. Epub 2019 Mar 7.

State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, 410081, China. Electronic address:

NOD-like receptor (NLR) family member X1 (NLRX1) of human localizes on mitochondria and serves as a negative regulator of antiviral signaling. However, the function of NLRX1 in teleost fish still remains elusive. To explore its role in the innate immunity of teleost fish, NLRX1 homologue has been cloned and characterized from black carp (Mylopharyngodon piceus). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X193004
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http://dx.doi.org/10.1016/j.dci.2019.03.001DOI Listing
July 2019
4 Reads

Molecular cloning and characterization of the pig MHC class Ⅰ-related MR1 gene.

Dev Comp Immunol 2019 Jul 2;96:58-67. Epub 2019 Mar 2.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, Gansu Province, 730046, People's Republic of China; Jiangsu Co-Innovation Center for Prevention and Control of Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province, 225009, People's Republic of China. Electronic address:

Major histocompatibility complex (MHC) class Ⅰ-related protein 1 (MR1), the most highly conserved MHC class Ⅰ molecule among mammals, is the restricting molecule for mucosal-associated invariant T (MAIT) cells. MAIT cells, a novel subset of T cells, play important roles in modulating the immune responses to infectious and non-infectious diseases, and recognize antigens in the context of MR1. MR1 has been identified in many species, including human, mouse, sheep, and cow. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.020DOI Listing
July 2019
2 Reads

microRNA-144 regulates the NF-κB signaling in miiuy croaker via targeting IL1β.

Dev Comp Immunol 2019 Jul 1;96:47-50. Epub 2019 Mar 1.

Laboratory of Fish Biogenetics & Immune Evolution, College of Marine Science, Zhejiang Ocean University, Zhoushan, 316022, China; Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China; Laboratory of Fish Molecular Immunology, College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, 201306, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Ministry of Education, 201306, China. Electronic address:

microRNAs have been demonstrated to be critical regulators of the immune responses. While, the miRNA-mediate the detail regulatory mechanism response is still not clear in fish species. In this research, the regulation of miRNA to the NF-κB signaling through decreasing the target gene mRNAs was discussed in miiuy croaker. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.018DOI Listing
July 2019
1 Read

Regulation of FOXP3 expression in myeloid cells in response to all-trans-retinoic acid, interleukin 2 and transforming growth factor β.

Dev Comp Immunol 2019 Jul 1;96:18-26. Epub 2019 Mar 1.

Department of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383, Wrocław, Poland. Electronic address:

FoxP3 is a transcription factor essential for differentiation and function of T regulatory cells (Tregs). There are two major subsets of Tregs: natural Tregs (nTregs) generated in thymus and inducible Tregs (iTregs) produced in peripheral immune system. It has been documented that iTreg development is dependent on soluble mediators including interleukin 2 (IL2), transforming growth factor β (TGFβ) and all-trans-retinoic acid (ATRA). Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.019DOI Listing

Bombyx mori cypovirus encoded small peptide inhibits viral multiplication.

Dev Comp Immunol 2019 Jul 26;96:51-57. Epub 2019 Feb 26.

School of Biology & Basic Medical Science, Soochow University, Suzhou, 215123, China; National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, China; Agricultural Biotechnology Research Institute, Agricultural Biotechnology and Ecological Research Institute, Soochow University, Suzhou, 215123, China. Electronic address:

Bombyx mori cypovirus (BmCPV) is one of the most infectious pathogen in sericulture and a member of the family Reoviridae. It specifically infects the midgut of silkworm. The BmCPV genome consists of 10 dsRNAs segments (S1-S10), which have generally been assumed to be monocistronic. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183058
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http://dx.doi.org/10.1016/j.dci.2019.02.017DOI Listing
July 2019
4 Reads

Functional characterization of Cystatin C in orange-spotted grouper, Epinephelus coioides.

Dev Comp Immunol 2019 Jul 27;96:37-46. Epub 2019 Feb 27.

College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address:

Cystatin C is an endogenous inhibitor of cysteine proteases and widely exist in organisms. Several studies in mammals have showed that Cystatin C plays critical role in the immune defense against microorganisms. It is also well known that some fish Cystatin C have important immune regulation functions in inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.015DOI Listing

Lyn is involved in host defense against S. agalactiae infection and BCR signaling in Nile tilapia (Oreochromis niloticus).

Dev Comp Immunol 2019 Jul 26;96:1-8. Epub 2019 Feb 26.

School of Life Sciences, South China Normal University, Institute of Modern Aquaculture Science and Engineering, Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Guangzhou, 510631, PR China. Electronic address:

Lyn, a member of Src protein kinase family, plays a crucial role in immune reactions against pathogenic infection. In this study, Lyn from Nile tilapia (Oreochromis niloticus) (OnLyn) was identified and characterized at expression pattern against bacterial infection, and regulation function in BCR signaling. The open reading frame of OnLyn contained 1536 bp of nucleotide sequence encoded a protein of 511 amino acids. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.013DOI Listing
July 2019
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Molecular identification and antiviral function of the guanylate-binding protein (GBP) genes in the Chinese tree shrew (Tupaia belangeri chinesis).

Dev Comp Immunol 2019 Jul 25;96:27-36. Epub 2019 Feb 25.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, 650204, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China; Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China. Electronic address:

Following viral detection and interferons (IFNs) production, several hundreds of IFN-stimulated genes (ISGs) are subsequently induced to act as direct antiviral effectors or regulators of the IFN signaling. The guanylate-binding protein (GBP) family belongs to IFN-inducible GTPases defending the host against a diverse group of invading pathogens such as parasites, bacteria and viruses. The Chinese tree shrew (Tupaia belangeri chinese) has been increasingly used as an alternative experimental animal to primates in studying viral infectious diseases. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.014DOI Listing
July 2019
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Transcriptomic insight into antimicrobial peptide factors involved in the prophylactic immunity of crowded Mythimna separata larvae.

Dev Comp Immunol 2019 Feb 19;98:34-41. Epub 2019 Feb 19.

College of Horticulture and Plant Protection, Yangzhou University, Wenhui East Road, NO. 48, Yangzhou, Jiangsu Province, 225009, China.

Similar to pathogenic infection, a high population density alters insect prophylactic immunity. Antimicrobial peptides (AMPs) are known to play critical roles in an insect's humoral immune response to microbial infection. We applied RNA sequencing to investigate differential gene expression levels in fat body and hemocyte samples from larvae reared in high- (10 larvae per jar) and low-density (1 larva per jar) conditions; the samples exhibited density-dependent prophylaxis. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.009DOI Listing
February 2019
3 Reads
2.815 Impact Factor

Fish-derived antimicrobial peptides: Activity of a chionodracine mutant against bacterial models and human bacterial pathogens.

Dev Comp Immunol 2019 Jul 18;96:9-17. Epub 2019 Feb 18.

Department for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia, Viterbo, Italy. Electronic address:

The increasing resistance to conventional antibiotics is an urgent problem that can be addressed by the discovery of new antimicrobial drugs such as antimicrobial peptides (AMPs). AMPs are components of innate immune system of eukaryotes and are not prone to the conventional mechanisms that are responsible of drug resistance. Fish are an important source of AMPs and, recently, we have isolated and characterized a new 22 amino acid residues peptide, the chionodracine (Cnd), from the Antarctic icefish Chionodraco hamatus. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.012DOI Listing

A prophylactic role of a secretory PLA of Spodoptera exigua against entomopathogens.

Dev Comp Immunol 2019 06 16;95:108-117. Epub 2019 Feb 16.

Department of Plant Medicals, Andong National University, Andong, 36729, South Korea. Electronic address:

Phospholipase A (PLA) hydrolyses phospholipids at sn-2 position to release free fatty acids and lysophospholipids. Secretory type of PLA (sPLA) has been found in many different animals including insects. Insect sPLAs have been divided into venomous and nonvenomous PLAs. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.008DOI Listing

Teleost contributions to the understanding of mycobacterial diseases.

Dev Comp Immunol 2019 Jul 15;96:111-125. Epub 2019 Feb 15.

Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Few pathogens have shaped human medicine as the mycobacteria. From understanding biological phenomena driving disease spread, to mechanisms of host-pathogen interactions and antibiotic resistance, the Mycobacterium genus continues to challenge and offer insights into the basis of health and disease. Teleost fish models of mycobacterial infections have progressed significantly over the past three decades, now supplying a range of unique tools and new opportunities to define the strategies employed by these Gram-positive bacteria to overcome host defenses, as well as those host antimicrobial pathways that can be used to limit its growth and spread. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.011DOI Listing

Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E-eIF4A axis in the insect Spodoptera litura.

Dev Comp Immunol 2019 06 15;95:101-107. Epub 2019 Feb 15.

School of Life Sciences, Yunnan University, Kunming, 650500, PR China; Key Laboratory of the University in Yunnan Province for International Cooperation in Intercellular Communications and Regulations, Yunnan University, Kunming, 650500, PR China; Biocontrol Engineering Research Centre of Crop Disease & Pest in Yunnan Province, Kunming, 650500, PR China; Key Laboratory for Biochemistry and Molecular Biology and School of Life Sciences, Yunnan University, Kunming, 650500, PR China; Animal Genetic Diversity and Evolution of High Education in Yunnan Province, School of Life Sciences, Yunnan University, Kunming, 650500, PR China. Electronic address:

Eukaryotic initiation factor 4E (eIF4E) is regulated during the innate immune response. However, its translational regulation under innate immune suppression remains largely unexplored. Microplitis bicoloratus bracovirus (MbBV), a symbiotic virus harbored by the parasitoid wasp, Microplitis bicoloratus, suppresses innate immunity in parasitized Spodoptera litura. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.010DOI Listing
June 2019
2 Reads
2.815 Impact Factor

γδ T cells are the predominant T cell type in opossum mammaries during lactation.

Dev Comp Immunol 2019 06 12;95:96-100. Epub 2019 Feb 12.

Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, 1 University of New Mexico, MSC03-2020, Albuquerque, NM, 87131-1091, USA. Electronic address:

Milk provides mammalian neonates with nutritional support and passive immunity. This is particularly true in marsupials where young are born highly altricial and lacking many components of a fully functional adaptive immune system. Here we investigated the T cell populations in the mammaries of a lactating marsupial, the gray short-tailed opossum Monodelphis domestica. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.005DOI Listing

Immunoprofiling of peripheral blood from infectious bronchitis virus vaccinated MHC-B chicken lines - Monocyte MHC-II expression as a potential correlate of protection.

Dev Comp Immunol 2019 Jul 11;96:93-102. Epub 2019 Feb 11.

Department of Animal Science, Aarhus University, Blichers Allé 20, 8830, Tjele, Denmark. Electronic address:

Vaccination programs are implemented in poultry farms to limit outbreaks and spread of infectious bronchitis virus (IBV), which is a substantial economic burden in the poultry industry. Immune correlates, used to predict vaccine efficacy, have proved difficult to find for IBV-vaccine-induced protection. To find correlates of IBV-vaccine-induced protection, hence, we employed a flow cytometric assay to quantify peripheral leucocyte subsets and expression of cell surface markers of six different non-vaccinated and vaccinated Major Histocompatibility Complex (MHC) haplotypes. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.004DOI Listing
July 2019
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Expression of avian β-defensin mRNA in the chicken yolk sac.

Dev Comp Immunol 2019 06 10;95:89-95. Epub 2019 Feb 10.

Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, 24061, USA. Electronic address:

The chicken yolk sac (YS) plays an important role in nutrient absorption and immune function for the developing embryo. The avian β-defensins (AvBD) are cationic peptides that are important members of the innate immune system. The objective of this study was to profile AvBD mRNA expression patterns and distribution of cells expressing AvBD mRNA in the chicken YS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0145305X183044
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http://dx.doi.org/10.1016/j.dci.2019.02.006DOI Listing
June 2019
7 Reads
2.815 Impact Factor

Novel insights into the evolution of the caveolin superfamily and mechanisms of antiapoptotic effects and cell proliferation in lamprey.

Dev Comp Immunol 2019 06 8;95:118-128. Epub 2019 Feb 8.

College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China. Electronic address:

Caveolin-1 is the main structural and functional component of caveolin, and it is involved in the regulation of cholesterol transport, endocytosis, and signal transduction. Moreover, changes in caveolin-1 play an important role in tumorigenesis and inflammatory processes. Previous studies have demonstrated that human caveolin-1 is mainly located in the cell membrane and exhibits cell type- and stage-dependent functional differences during cancer development and inflammatory responses. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.005DOI Listing
June 2019
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Characterization, evolution, and expression analysis of TLR7 gene subfamily members in Mastacembelus armatus (Synbranchiformes: Mastacembelidae).

Dev Comp Immunol 2019 06 8;95:77-88. Epub 2019 Feb 8.

State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, PR China. Electronic address:

TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study, we successfully identified 3 members of TLR7 subfamily from the spiny eel Mastacembelus armatus (MaTLR7, MaTLR8 and MaTLR9). The amino acid sequence identities of MaTLR7 and MaTLR8 with Monopterus albus TLR7 were 87. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.002DOI Listing
June 2019
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Expression of TCR genes in adult and larval Xenopus laevis.

Dev Comp Immunol 2019 Jul 7;96:78-82. Epub 2019 Feb 7.

Chatham University, Woodland Road, Pittsburgh, PA, 15232, USA. Electronic address:

In order to better understand the development and function of γδ T cells in Xenopus frogs, it is necessary to determine where and when γδ T cells are found in Xenopus tissues. This study examined the expression of TCR genes, focused primarily on TCR γ, in tissues of adult and larval Xenopus laevis and provide new data about the expression pattern of these different TCR genes in this anuran amphibian. TCR gene expression was detected by RT-PCR in adult frog tissues including the thymus, spleen, skin, intestine, lung, and liver, but not the testes. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.007DOI Listing

Spp38 MAPK participates in maintaining the homeostasis of hemolymph microbiota in Scylla paramamosain.

Dev Comp Immunol 2019 06 6;95:38-49. Epub 2019 Feb 6.

Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou 515063, China; STU-UMT Joint Shellfish Research Laboratory, Shantou University, Shantou 515063, China. Electronic address:

The p38 mitogen-activated protein kinases (MAPKs) are evolutionally conserved from yeasts to mammals, and are involved in the regulation of cells response to various extracellular stimuli. In this study, the p38 MAPK gene (designated as Spp38) of mud crab (Scylla paramamosain) was identified and studied. Spp38 contained the conserved Thr-Gly-Tyr (TGY) motif and a Ala-Thr-Arg-Trp (ATRW) substrate-binding site. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.003DOI Listing
June 2019
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An in vitro study of NF-κB factors cooperatively in regulation of Drosophila melanogaster antimicrobial peptide genes.

Dev Comp Immunol 2019 06 6;95:50-58. Epub 2019 Feb 6.

Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri - Kansas City, Kansas City, MO, 64110, USA; School of Life Sciences, Central China Normal University, Wuhan, 430079, China; Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China; Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China. Electronic address:

An important innate immune response in Drosophila melanogaster is the production of antimicrobial peptides (AMPs). Expression of AMP genes is mediated by the Toll and immune deficiency (IMD) pathways via NF-κB transcription factors Dorsal, DIF and Relish. Dorsal and DIF act downstream of the Toll pathway, whereas Relish acts in the IMD pathway. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.017DOI Listing
June 2019
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Ingestion of killed bacteria activates antimicrobial peptide genes in Drosophila melanogaster and protects flies from septic infection.

Dev Comp Immunol 2019 06 4;95:10-18. Epub 2019 Feb 4.

School of Life Sciences, Central China Normal University, Wuhan, 430079, China; Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, Kansas City, MO, 64110, USA. Electronic address:

Drosophila melanogaster possesses a sophisticated and effective immune system composed of humoral and cellular immune responses, and production of antimicrobial peptides (AMPs) is an important defense mechanism. Expression of AMPs is regulated by the Toll and IMD (immune deficiency) pathways. Production of AMPs can be systemic in the fat body or a local event in the midgut and epithelium. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.001DOI Listing
June 2019
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20-Hydroxyecdysone regulates the transcription of the lysozyme via Broad-Complex Z2 gene in silkworm, Bombyx mori.

Dev Comp Immunol 2019 05 1;94:66-72. Epub 2019 Feb 1.

State Key Laboratory of Silkworm Genome Biology, Southwest University, 400716, Chongqing, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, 400716, Chongqing, China; Southwest University Engineering Research Center for Cancer Biomedical and Translational Medicine, 400716, Chongqing, China.

Broad-Complex Z2 (Br-C Z2) is an ecdysone inducible transcription factor that regulates physiological, innate immune and developmental events in insects. Here, we identified an orthologue of Br-C Z2 from silkworm, Bombyx mori (BmBr-C Z2) to study its involvement in immune responses. The quantitative real-time PCR analysis revealed that BmBr-C Z2 was expressed ubiquitously in all tested tissues under normal physiological conditions. Read More

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http://dx.doi.org/10.1016/j.dci.2019.01.014DOI Listing
May 2019
1 Read
2.815 Impact Factor