400,305 results match your criteria Developmental Neuroscience[Journal]
J Proteomics 2018 Dec 11. Epub 2018 Dec 11.
Laboratory of Evolutionary and Adaptive Physiology - Institute of Life, Earth and Environment - University of Namur, 61 Rue de Bruxelles, B5000 Namur, Belgium.
Early-life represents a critically sensitive window to endocrine disrupting chemicals, potentially leading to long-term repercussions on the phenotype later in life. The mechanisms underlying this phenomenon, referred to as the Developmental Origins of Health and Disease (DOHaD), are still poorly understood. To gain molecular understanding of these effects, we exposed mangrove rivulus (Kryptolebias marmoratus) for 28 days post hatching (dph) to 4 and 120 ng/L 17-α-ethinylestradiol, a model xenoestrogen. Read More
Semin Cancer Biol 2018 Dec 11. Epub 2018 Dec 11.
Molecular Oncology group, Biodonostia Research Institute, Paseo Doctor Begiristain, s/n San Sebastián, 20014, Spain; Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom; IKERBASQUE, Basque Foundation for Science, María Díaz Haroko Kalea, 3, 48013, Bilbao, Spain. Electronic address:
Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively abundant have only recently begun to be explored. There are many thousands of genes that appear capable of producing circRNAs, however the function of all but a handful remain to be determined. What is emerging about these highly conserved molecules is that they play important roles in biology and cancer biology in particular. Read More
Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.
J.P. Scott Center for Neuroscience, Mind & Behavior, and Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.
Although scientific research using mammalian models has made great strides in uncovering the enigmatic neural and molecular mechanisms orchestrating the state of drug addiction, a complete understanding has thus far eluded researchers. The complexity of the task has led to the use of invertebrate model systems to complement the research of drug-induced reward in mammalian systems. Invertebrates, such as crayfish, offer excellent model systems to help reveal the underlying mechanisms of drug addiction as they retain the ancestral neural reward circuit that is evolutionarily conserved across taxa, and they possess relatively few, large neurons, laid out in an accessible, modularly organized nervous system. Read More
Breast 2018 Dec 7;43:123-129. Epub 2018 Dec 7.
Non-Communicable Diseases Research Division, Wits Health Consortium (PTY) Ltd, 31 Princess of Wales Building, Johannesburg, 2193, South Africa; Department of Medicine, University of Witwatersrand Faculty of Health Sciences, 7 York Road Johannesburg, South Africa.
Purpose: Breast cancer is the most common cancer in women and a leading cause of cancer-related mortality worldwide. South Africa has the largest global burden of HIV infection and the largest anti-retroviral treatment (ART) program. This study aimed to analyse the association of HIV and ART use with breast cancer clinico-pathological characteristics. Read More
Neurosci Lett 2018 Dec 11. Epub 2018 Dec 11.
The Ohio State University, United States. Electronic address:
In this research, the concept of fractality based on nonlinear science and chaos theory is explored to study and evaluate the complexity of speech-evoked auditory brainstem response (s-ABR) time series in order to capture its intrinsic multiscale dynamics. The visibility graph of the s-ABR series is proposed as a quantitative method to differentiate subjects with persistent developmental stuttering (PDS) from the normal group. Differential complexities between normal and PDS subjects is quantified using Graph index complexity (GIC). Read More
Neural Netw 2018 Nov 27;110:116-130. Epub 2018 Nov 27.
Department of Computer Science and Engineering, Michigan State University, East Lansing, MI, 48824, USA; Cognitive Science Program, Michigan State University, East Lansing, MI, 48824, USA; Neuroscience Program, Michigan State University, East Lansing, MI, 48824, USA.
Traditional Turing Machines (TMs) are symbolic whose hand-crafted representations are static and limited. Developmental Network 1 (DN-1) uses emergent representation to perform Turing Computation. But DN-1 lacks hierarchy in its internal representations, and is hard to handle the complex visual navigation tasks. Read More
Cell 2018 Dec;175(7):1931-1945.e18
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA; The J. David Gladstone Institutes, San Francisco, CA, USA. Electronic address:
Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We used affinity purification-mass spectrometry (AP-MS) to compare flavivirus-host interactions for two viruses (DENV and ZIKV) in two hosts (human and mosquito). Read More
Cell 2018 Dec;175(7):1902-1916.e13
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. Electronic address:
Nuclear architecture has never been carefully examined during early mammalian development at the stages leading to establishment of the embryonic and extra-embryonic lineages. Heterogeneous activity of the methyltransferase CARM1 during these stages results in differential methylation of histone H3R26 to modulate establishment of these two lineages. Here we show that CARM1 accumulates in nuclear granules at the 2- to 4-cell stage transition in the mouse embryo, with the majority corresponding to paraspeckles. Read More
Cell Signal 2018 Dec 11. Epub 2018 Dec 11.
Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland. Electronic address:
Solid tumor microenvironments are often subjected to various levels of hypoxia. Although regulation of gene expression has been examined extensively, most studies have focused on prolonged hypoxia. The tumor microenvironment, however, experiences waves of hypoxia and reoxygenation that stimulate the expression of pro-angiogenic factors that promote blood vessel formation. Read More
J Pediatr (Rio J) 2018 Dec 11. Epub 2018 Dec 11.
Stanford University School of Medicine, Department of Pediatrics, Division of Neonatal and Developmental Medicine, Palo Alto, United States. Electronic address:
J Invertebr Pathol 2018 Dec 11. Epub 2018 Dec 11.
Institute for Biological Control, Federal Research Centre for Cultivated Plants, Julius Kühn Institute, Heinrichstraße 243, 64287 Darmstadt, Germany. Electronic address:
An antagonistic effect of a microsporidium (Nosema sp.) infection on the virulence of Phthorimaea operculella granulovirus (PhopGV) was recorded in potato tuber moth (Phthorimaea operculella) larvae with mixed infections. When the P. Read More
Psychol Rep 2018 Dec 14:33294118811620. Epub 2018 Dec 14.
Department of Psychiatry, Pomeranian Medical University in Szczecin, Poland.
This paper touches upon gender differences concerning psychosocial factors related to the emotional reaction of gratitude and forms of expressing gratitude in quasi-experimental conditions. It is based on findings from a study conducted on 576 participants of both sexes, aged 14 to 86 years. There were used three versions of the same questionnaire, depending on the type of the received good-material, intangible, or none. Read More
Annu Rev Clin Psychol 2018 Dec 14. Epub 2018 Dec 14.
Department of Clinical, Neuro-, and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands; email:
Psychotherapies may work through techniques that are specific to each therapy or through factors that all therapies have in common. Proponents of the common factors model often point to meta-analyses of comparative outcome studies that show all therapies have comparable effects. However, not all meta-analyses support the common factors model; the included studies often have several methodological problems; and there are alternative explanations for finding comparable outcomes. Read More
J Bone Miner Res 2018 Dec 14. Epub 2018 Dec 14.
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
HB-EGF, a member of the EGF superfamily, plays important roles in development and tissue regeneration. However, its functions in skeletal stem cells and skeleton development and growth remain poorly understood. Here, we used the Cre/LoxP system to ablate or express HB-EGF in Dermo1+ mesenchymal stromal cells and their progenies, including chondrocytes and osteoblast lineage cells, and bone marrow stromal cells (BMSCs). Read More
PLoS One 2018 14;13(12):e0209095. Epub 2018 Dec 14.
Division of Neonatology and Pediatric Molecular and Personalized Medicine Program, Department of Pediatrics, University of Rochester, Rochester, New York, United States of America.
Basement membrane (BM) is an essential part of the extracellular matrix (ECM) that plays a crucial role in mechanical support and signaling to epithelial cells during lung development, homeostasis and repair. Abnormal composition and remodeling of the lung ECM have been associated with developmental abnormalities observed in multiple pediatric and adult respiratory diseases. Collagen VI (COL6) is a well-studied muscle BM component, but its role in the lung and its effect on pulmonary epithelium is largely undetermined. Read More
PLoS One 2018 14;13(12):e0209417. Epub 2018 Dec 14.
Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America.
Uterine gland development, also known as adenogenesis, is a key uterine morphogenic process indispensable for normal uterine function and fertility. Our earlier studies have reported that overactivation of TGFB receptor 1 (TGFBR1) in the mouse uterus using progesterone receptor (Pgr)-Cre recombinase causes female infertility, defective decidualization, and reduced uterine gland formation, a developmental milestone of postnatal uterus. To understand mechanisms that underpin the disrupted uterine gland formation in mice with sustained activation of TGFBR1, we raised the question of whether early postnatal adenogenesis was compromised in these mice. Read More
PLoS One 2018 14;13(12):e0209233. Epub 2018 Dec 14.
Laboratory of Functional Morphology, Department of Biology, Faculty of Sciences, University of Antwerp, Wilrijk, Belgium.
Intrauterine crowding (IUC) considerably influences postnatal traits in a polytocous species such as the pig. Previously, our group described how IUC affects locomotion during the piglet's first days of life (until 96 h after birth). We noted a reduced motor performance in piglets with a low birth weight and low vitality (L piglets), compared to piglets with a normal birth weight and normal vitality (N piglets), indicating L piglets are unable to produce enough force. Read More
J Pediatr Orthop B 2018 Dec 13. Epub 2018 Dec 13.
Departments of Paediatric Orthopaedic Surgery.
Quality of spontaneous amelioration of residual developmental dysplasia of the hip (DDH) is nowadays not possible to predict. Normal age-related values of the osseous acetabular index (OAI), cartilaginous acetabular index and labral acetabular index have been established on MRI. In this study, MRI of dysplastic hips has been evaluated, and further osseous acetabular maturation was followed-up over time on pelvic radiography to find a correlation between MRI findings and radiological evolution. Read More
Am J Nurs 2018 Dec 12. Epub 2018 Dec 12.
Christina C. Lawson is the epidemiology team leader, Candice Y. Johnson and Carissa M. Rocheleau are epidemiologists, and James M. Boiano is an industrial hygienist in the Division of Surveillance, Hazard Evaluations, and Field Studies at the National Institute for Occupational Safety and Health (NIOSH) in Cincinnati, OH. Feiby L. Nassan is a postdoctoral research fellow at the Harvard T. H. Chan School of Public Health in Boston. Thomas H. Connor is a research biologist in the Division of Applied Research and Technology at NIOSH. Jorge E. Chavarro is an associate professor in the Departments of Nutrition and Epidemiology at the Harvard T.H. Chan School of Public Health at Harvard Medical School, as well as the principal investigator of the Nurses' Health Study 3. Janet W. Rich-Edwards is the director of developmental epidemiology at the Mary Horrigan Connors Center for Women's Health and Gender Biology at Brigham and Women's Hospital and Harvard Medical School. Rich-Edwards received grant funding from NIOSH to support data analysis (grant no. 200-2013-M-54978). Contact author: Christina C. Lawson, The authors and planners have disclosed no potential conflicts of interest, financial or otherwise.
Findings from this cross-sectional study indicate a need for expanded training in safe handling practices.
Abstract: Background: Many antineoplastic (chemotherapeutic) drugs are known or probable human carcinogens, and many have been shown to be reproductive toxicants in cancer patients. Evidence from occupational exposure studies suggests that health care workers who have long-term, low-level occupational exposure to antineoplastic drugs have an increased risk of adverse reproductive outcomes. Read More
J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.
Birmingham Children's Hospital, Birmingham, UK.
Introduction: Single suture craniosynostosis (SSC) and isolated cleft palate (ICP) in non-Apert syndrome patients rarely occur together. Management includes airway optimization, timing surgery appropriately, and assessing both cranial vault aesthetics and speech outcomes. The aim of this study was to compare treatment pathways and outcomes in patients with both conditions to standard treatment for these conditions in isolation. Read More
J Pers Soc Psychol 2018 Dec 13. Epub 2018 Dec 13.
Department of Psychology.
This longitudinal study over a 23-year time span examined predictive associations between self-control development in adolescence and love and work outcomes in adulthood. Participants were 1,527 adults aged 35 years (48.3% female). Read More
Dev Psychol 2018 Dec 13. Epub 2018 Dec 13.
Carolina Population Center, Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill.
The goal of this article was to examine gender-typed behavior longitudinally and to consider its relationship with sexual orientation in adulthood. Data were from 10,624 respondents who completed Wave 1 (adolescence), Wave 3 (emerging adulthood), and Wave 4 (early adulthood) of the National Longitudinal Study of Adolescent to Adult Health. First, we described the distributions of gender-typed behavior by adult sexual orientation at each of the three developmental stages. Read More
Hist Psychol 2018 Dec 13. Epub 2018 Dec 13.
A common view among ancient historians about Roman attentiveness to children's psychological development needs reconsideration. The view holds that Romans ignored children's cognitive ontogeny, perceiving early childhood as a largely undifferentiated life stage. A separate but related issue is the problematic claim that Roman childhood was entirely a matter of social construction. Read More
Emotion 2018 Dec 13. Epub 2018 Dec 13.
Institute of Psychology, Humboldt-Universität zu Berlin.
Within the study of emotions, researchers have increasingly stressed the importance of studying individual differences in emotion dynamics and emotional responding and the way these relate to more stable differences in well-being. However, there is no clear picture regarding affective reactivity to positive events and how different emotional reactions relate to differences in well-being, particularly higher levels of well-being. Theoretical work and empirical findings from different lines of research (e. Read More
J Tissue Eng Regen Med 2018 Dec 14. Epub 2018 Dec 14.
Regenerative, Modular & Developmental Engineering Laboratory (REMODEL), Biomedical Sciences Building, National University of Ireland Galway (NUI Galway), Galway, Ireland.
Chondrocyte-based tissue engineering requires in vitro cell expansion, which is associated with phenotypic losses, decrease in collagen II synthesis and increase in collagen I synthesis. Another major obstacle in clinical translation of chondrocyte-based therapies is the lack of extracellular matrix (ECM) in the engineered cartilage substitutes. Various research and commercially available media claim that can maintain chondrogenic phenotype, whilst macromolecular crowding (MMC) has been shown to increase tissue-specific ECM deposition and to maintain cell phenotype in vitro. Read More
Insect Sci 2018 Dec 14. Epub 2018 Dec 14.
CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China.
Identification of stage- and tissue-specific cis-regulatory elements will enable more precise genomic editing. In previous studies of the silkworm Bombyx mori, we identified and characterized several tissue and sex-specific cis-regulatory elements using transgenic technology, including a female- and fat body-specific promoter, vitellogenin; testis-specific promoters, Radial spoke head 1 (BmR1) and beta-tubulin 4 (Bmβ4). Here we reported a cis-regulatory element specific for a somatic and germ cell expressed promoter, nanos (Bmnos). Read More
Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
Wiedemann-Steiner syndrome is a genetic condition associated with dysmorphic facies, hypertrichosis, short stature, developmental delay, and intellectual disability. Congenital malformations of the cerebral, cardiac, renal, and optic structures have also been reported. Because the majority of reported individuals with this condition have been under age 20, the long-term prognosis is not well defined. Read More
Ecol Appl 2018 Dec 14. Epub 2018 Dec 14.
National Research Council of Italy, Institute for Agriculture and Forestry Systems, in the Mediterranean (CNR-ISAFOM), 87036, Rende, CS, Italy.
The future trajectory of atmospheric CO concentration depends on the development of the terrestrial carbon sink, which in turn is influenced by forest dynamics under changing environmental conditions. An in-depth understanding of model sensitivities and uncertainties in non steady-state conditions is necessary for reliable and robust projections of forest development and under scenarios of global warming and CO -enrichment. Here, we systematically assessed if a bio-geochemical process-based model (3D-CMCC-CNR), which embeds similarities with many other vegetation models, applied in simulating net primary productivity (NPP) and standing woody biomass (SWB), maintained a consistent sensitivity to its 55 input parameters through time, during forest-ageing and -structuring as well as under climate-change scenarios. Read More
Alcohol Clin Exp Res 2018 Dec 14. Epub 2018 Dec 14.
Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR.
Introduction: Gestational ethanol exposure is associated with multiple developmental abnormalities, collectively termed fetal alcohol spectrum disorder (FASD). While the majority of women abstain from ethanol following knowledge of pregnancy, one contributing factor to the high FASD prevalence is that pregnancy is not detected until 4-6 weeks. Thus, ethanol consumption continues during the initial stages of fetal development. Read More
Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Purpose: The aim of the study was to report prevalence, ocular outcome, neurological characteristics, cognitive and behavioural problems in children with optic disc coloboma (ODC).
Methods: This was a population-based, cross-sectional study of 31 children between 2 and 18 years of age diagnosed with ODC. The children were part of a larger cohort of 184 children with congenital optic disc malformations. Read More
Plant Biotechnol J 2018 Dec 13. Epub 2018 Dec 13.
State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, 100101, China.
CRISPR-Cas9 systems have been widely used in animals and plants for genome editing, epigenetic modification, etc. (Cong et al., 2013, Hilton et al. Read More
FEBS J 2018 Dec 13. Epub 2018 Dec 13.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Single-cell technologies that can quantify features of individual cells within a tumor are critical for treatment strategies aiming to target cancer cells while sparing or activating beneficial cells. Given that key players in protein networks are often the primary targets of precision oncology strategies, it is imperative to transcend the nucleic acid message and read cellular actions in human solid tumors. Here, we review the advantages of single-cell mass cytometry. Read More
Environ Toxicol 2018 Dec 13. Epub 2018 Dec 13.
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, China.
Graphene oxide (GO) has emerged as the worldwide promising candidate for biomedical application, such as for drug delivery, bio-sensing and anti-cancer therapy. This study was focused on the zebrafish and RAW264.7 cell line as in vivo and in vitro models to assess the potential developmental neurotoxicity and immunotoxicity of GO. Read More
Aging Cell 2018 Dec 13:e12854. Epub 2018 Dec 13.
Division of Human Reproduction and Developmental Genetics, The Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
By the end of neurogenesis in Drosophila pupal brain neuroblasts (NBs), nuclear Prospero (Pros) triggers cell cycle exit and terminates NB lifespan. Here, we reveal that in larval brain NBs, an intrinsic mechanism facilitates import and export of Pros across the nuclear envelope via a Ran-mediated nucleocytoplasmic transport system. In rangap mutants, the export of Pros from the nucleus to cytoplasm is impaired and the nucleocytoplasmic transport of Pros becomes one-way traffic, causing an early accumulation of Pros in the nuclei of the larval central brain NBs. Read More
Ultrasound Obstet Gynecol 2018 Dec 13. Epub 2018 Dec 13.
Fetal Medicine Department, Zydus hospital, Ahmedabad, India.
Diencephalic mesencephalic junction (DMJ) dysplasia is a rare malformation characterized by ill -defined junction of the diencephalon and mesencephalon and clinical features of spastic-dystonic tetraparesis, hypothalamic dysfunction, epilepsy, and developmental delay(1). This article is protected by copyright. All rights reserved. Read More
Gerodontology 2018 Dec 14. Epub 2018 Dec 14.
Cooperative Research Centre for Oral Health Science Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia.
Aims: The aim of this study was to explain through the life-course and life-span perspectives of developmental regulation theory the controls on dental experiences and beliefs throughout the lives of older people in Guangzhou and Hong Kong.
Background: Dental diseases and disabilities among older people are serious public health concerns in China.
Methods: A facilitator conducted eight focus groups, three in Hong Kong and five in Guangzhou, involving a total of 51 participants. Read More
J Anat 2018 Dec 13. Epub 2018 Dec 13.
Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
The objective of this paper was to collect normative data essential for analyzing the subplate (SP) role in pathogenesis of developmental disorders, characterized by abnormal circuitry, such as hypoxic-ischemic lesions, autism and schizophrenia. The main cytological features of the SP, such as low cell density, early differentiation of neurons and glia, plexiform arrangement of axons and dendrites, presence of synapses and a large amount of extracellular matrix (ECM) distinguish this compartment from the cell-dense cortical plate (CP; towards pia) and large fiber bundles of external axonal strata of fetal white matter (towards ventricle). For SP delineation from these adjacent layers based on combined cytological criteria, we analyzed the sublaminar distribution of different microstructural elements and the associated maturational gradients throughout development, using immunocytochemical and histological techniques on postmortem brain material (Zagreb Neuroembryological Collection). Read More
Plant J 2018 Dec 13. Epub 2018 Dec 13.
Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Piazzale A. Moro, 00185, Roma, Italy.
The architecture of the plant cell wall is highly dynamic, being substantially re-modelled during growth and development. Cell walls determine size and shape of cells and contribute to the functional specialization of tissues and organs. Beyond the physiological dynamics, the wall structure undergoes changes upon biotic or abiotic stresses. Read More
Dev Med Child Neurol 2018 Dec 13. Epub 2018 Dec 13.
Children's Neurosciences, Evelina London Children's Hospital, St Thomas' Hospital, King's Health Partners Academic Health Science Centre, London, UK.
Aim: In an attempt to clarify the debate surrounding the diagnostic validity of childhood disintegrative disorder (CDD), we systematically reviewed its characteristics and compared it with autism spectrum disorder (ASD).
Method: Four databases were searched (PubMed, PsycINFO, Embase, and Web of Science). Included articles had participants with CDD, as defined by symptoms present in the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision and the International Classification of Diseases, 10th Revision. Read More
Anat Rec (Hoboken) 2018 Dec 12. Epub 2018 Dec 12.
Laboratory of Neurogenetics of Language, Rockefeller University, New York, NY, 10065.
At birth a mammalian neonate enters an extreme environment compared to the intrauterine environment in which it has grown. This transition may be particularly extreme in marsupials because they are born at an exceedingly altricial state, after an exceptionally short gestation. Their stage of development must be considered embryonic by almost any criteria. Read More
Proteomics Clin Appl 2018 Dec 13:e1800135. Epub 2018 Dec 13.
A. K. Lucas-Herald, B. Mansoorian, W. Mullen, C. Delles, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Background: Progeria-like syndromes offer a unique insight into ageing. Here we present the case of a boy affected with mandibuloacral dysplasia and compound heterozygous mutations in ZMPSTE24.
Methods: Capillary electrophoresis-mass spectroscopy was used for proteome analysis to analyse peptides previously found to be differentially regulated in chronic kidney disease (273 peptides defining the CKD273 classifier), coronary artery disease (238 peptides defining the CAD238 classifier) and ageing (116 peptides defining the AGE116 classifier). Read More
Pest Manag Sci 2018 Dec 12. Epub 2018 Dec 12.
FMC Agricultural Solutions, Global Regulatory Sciences, Ewing, NJ, 08628.
Background: Bifenthrin is usually considered a Type I pyrethroid, because it lacks an α-CN group present in Type II pyrethroids, but some previous studies suggest a mixed Type I/II mode-of-action. Results are presented for bifenthrin in a rat developmental neurotoxicity (DNT) study along with effects on Na currents in human VGSC subtypes. Molecular modeling comparisons were also made for bifenthrin and other pyrethroids. Read More
Dev Sci 2018 Dec 13:e12786. Epub 2018 Dec 13.
School of Psychology, University of Surrey, Guilford, Surrey, GU27XH, UK.
Spatial thinking is an important predictor of mathematics. However, existing data do not determine whether all spatial sub-domains are equally important for mathematics outcomes nor whether mathematics-spatial associations vary through development. This study addresses these questions by exploring the developmental relations between mathematics and spatial skills in children aged 6 -10 years (N = 155). Read More
New Phytol 2018 Dec 12. Epub 2018 Dec 12.
Department of Plant Developmental Biology, Institute of Experimental Biology, Faculty of Biological Sciences, University of Wrocław, Kanonia 6/8, 50-328, Wrocław, Poland.
In trees, dead and living cells of secondary xylem (wood) function collectively, rendering cell-to-cell communication challenging. Water and solutes are transported over long distances from the roots to the aboveground organs via vessels, the main component of wood, and then radially over short distances to the neighboring cells. This enables proper functioning of trees and integrates whole-plant activity. Read More
J Anim Ecol 2018 Dec 13. Epub 2018 Dec 13.
CNRS, Université Toulouse III Paul Sabatier, Station d'Écologie Théorique et Expérimentale du CNRS à Moulis, UMR-5321, F-09200, Moulis, France.
1.Global change is altering biodiversity locally and globally and subsequently affecting the dynamics of communities and ecosystems. Biodiversity can be impacted both at the interspecific (i. Read More
Dev Neurobiol 2018 Dec 12. Epub 2018 Dec 12.
Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Perinatal neurodevelopment involves extensive formation of neural connections and onset of activity-dependent gene expression for synaptic function and plasticity. Exposure to psychostimulants at this stage imposes significant risks for developing cognitive and affective disorders later in life. However, how developmental exposure to psychostimulants may induce long lasting molecular changes relevant to neural circuit function remains incompletely understood. Read More
J Neurosci Res 2018 Dec 12. Epub 2018 Dec 12.
Departments of Anesthesiology and Physiology, School of Medicine, Loma Linda University, Loma Linda, California.
The objectives of this present work were to review recent developments on the role of hypoxia-inducible factor (HIF) in the survival of cells under normoxic versus hypoxic and inflammatory brain conditions. The dual nature of HIF effects appears well established, based on the accumulated evidence of HIF playing both the role of adaptive factor and mediator of cell demise. Cellular HIF responses depend on pathophysiological conditions, developmental phase, comorbidities, and administered medications. Read More
Insect Mol Biol 2018 Dec 12. Epub 2018 Dec 12.
Laboratory for Evolution and Development, Genomics Aotearoa, Biochemistry Department, University of Otago, P.O. Box 56, Dunedin, Aotearoa, New Zealand.
Embryonic terminal patterning and moulting are critical developmental processes in insects. In Drosophila and Tribolium both of these processes are regulated by the Torso-activation cassette (TAC). The TAC consists of a common receptor, Torso, ligands Trunk and PTTH, and the spatially restricted protein Torso-like, with combinations of these elements acting mechanistically to activate the receptor in different developmental contexts. Read More
Dev Med Child Neurol 2018 Dec 12. Epub 2018 Dec 12.
Department of Neurology, University of California, San Francisco, CA, USA.
Aim: Our aim was to characterize the sensory processing outcome following neonatal arterial ischemic stroke (NAIS) and identify neuroanatomical correlates of abnormal sensory processing.
Method: We evaluated children with NAIS longitudinally at 12 months, 18 months, and/or 30 months in areas of cognitive, motor, and language development. We gathered sensory processing data using the Sensory Profile-2 Caregiver Questionnaire. Read More
J Neurosci Res 2018 Dec 12. Epub 2018 Dec 12.
Institute of Biotechnology, Program of Developmental Biology, University of Helsinki, Helsinki, Finland.
Adeno-associated virus (AAV) vector-mediated delivery of human α-synuclein (α-syn) gene in rat substantia nigra (SN) results in increased expression of α-syn protein in the SN and striatum which can progressively degenerate dopaminergic neurons. Therefore, this model is thought to recapitulate the neurodegeneration in Parkinson's disease. Here, using AAV to deliver α-syn above the SN in male and female rats resulted in clear expression of human α-syn in the SN and striatum. Read More