1,723 results match your criteria Developmental Neuroscience[Journal]


Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats.

Dev Neurosci 2019 Apr 18:1-10. Epub 2019 Apr 18.

Division of Pediatric Neurosurgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Introduction: Hydrocephalus is a multifactorial disease, affecting the dynamics of cerebrospinal fluid (CSF) and leading to severe neurological impairment in children; in spite of the recent advances in hydrocephalus research, it has many physiopathological aspects that still remain poorly understood, especially after treatment.

Objectives: To analyze the clinical, radiological, histopathological, and biochemical aspects of kaolin-induced hydrocephalus in an experimental model, both in the acute phase and after shunt treatment, by means of behavioral tests, magnetic resonance imaging (MRI) scans, histopathological studies, and level of inflammatory interleukins in the CSF.

Methods: Seven-day-old Wistar rats were used and subdivided into three subgroups: treated hydrocephalic (n = 24), untreated hydrocephalic (n = 17), and controls (n = 5). Read More

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http://dx.doi.org/10.1159/000497433DOI Listing

Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study.

Dev Neurosci 2019 Apr 18:1-12. Epub 2019 Apr 18.

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA,

Prenatal ethanol exposure alters brain structure, functional connectivity, and behavior in humans and rats. Behavioral changes include deficits in executive function, which requires cooperative activity between the frontal cortices and other brain regions. In this study, we analyzed the functional connectivity and neurochemical levels of the prefrontal cortex (PFC) using resting-state functional magnetic resonance imaging (rsfMRI) and proton magnetic resonance spectroscopy (1H-MRS) in ethanol-exposed (Eth) and control (Ctr) rats. Read More

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http://dx.doi.org/10.1159/000499183DOI Listing

The Arginase Pathway in Neonatal Brain Hypoxia-Ischemia.

Dev Neurosci 2019 Apr 17:1-14. Epub 2019 Apr 17.

Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.

Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner. Neuroprotective strategies assumed to be effective in adults might have deleterious effects in the immature brain. In order to create effective therapies, the complex pathophysiology of HI in the developing brain requires exploring new mechanisms. Read More

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https://www.karger.com/Article/FullText/496467
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http://dx.doi.org/10.1159/000496467DOI Listing
April 2019
1 Read

Assessing Cerebral Metabolism in the Immature Rodent: From Extracts to Real-Time Assessments.

Dev Neurosci 2019 Apr 16:1-12. Epub 2019 Apr 16.

Department of Pediatrics and Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA,

Brain development is an energy-expensive process. Although glucose is irreplaceable, the developing brain utilizes a variety of substrates such as lactate and the ketone bodies, β-hydroxybutyrate and acetoacetate, to produce energy and synthesize the structural components necessary for cerebral maturation. When oxygen and nutrient supplies to the brain are restricted, as in neonatal hypoxia-ischemia (HI), cerebral energy metabolism undergoes alterations in substrate use to preserve the production of adenosine triphosphate. Read More

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https://www.karger.com/Article/FullText/496921
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http://dx.doi.org/10.1159/000496921DOI Listing
April 2019
1 Read

How Early Can a Seizure Happen? Pathophysiological Considerations of Extremely Premature Infant Brain Development.

Dev Neurosci 2019 Apr 4:1-20. Epub 2019 Apr 4.

Division of Pediatric Neurology, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA,

Seizures in neonates represent a neurologic emergency requiring prompt recognition, determination of etiology, and treatment. Yet, the definition and identification of neonatal seizures remain challenging and controversial, in part due to the unique physiology of brain development at this life stage. These issues are compounded when considering seizures in premature infants, in whom the complexities of brain development may engender different clinical and electrographic seizure features at different points in neuronal maturation. Read More

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http://dx.doi.org/10.1159/000497471DOI Listing

Chorioamnionitis in Rats Precipitates Extended Postnatal Inflammatory Lymphocyte Hyperreactivity.

Dev Neurosci 2019 Mar 28:1-11. Epub 2019 Mar 28.

Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA,

Preterm birth is an important cause of perinatal brain injury (PBI). Neurological injury in extremely preterm infants often begins in utero with chorioamnionitis (CHORIO) or inflammation/infection of the placenta and concomitant placental insufficiency. Studies in humans have shown dysregulated inflammatory signaling throughout the placental-fetal brain axis and altered peripheral immune responses in children born preterm with cerebral palsy (CP). Read More

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http://dx.doi.org/10.1159/000497273DOI Listing
March 2019
1 Read

Age-Dependent Electrocorticogram Dynamics and Epileptogenic Responsiveness in Rats Subjected to Prenatal Hypoxia.

Dev Neurosci 2019 Mar 22:1-11. Epub 2019 Mar 22.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russian Federation,

Using electrocorticogram (ECoG) analysis, we compared age-related dynamics of general neuronal activity and convulsive epileptiform responsiveness induced by intracortical microinjections of 4-aminopyridine (4-AP) in control Wistar rats and those subjected to prenatal hypoxia (Hx; E14; 7% O2, 3 h). The studies were carried out in three age periods roughly corresponding to childhood (P20-27), adolescence (P30-45), and adulthood (P90-120). It was found that in the process of postnatal development of the control rats, the peak of the ECoG power spectrum density (PSD) of the theta rhythm during wakefulness shifted from the low to the higher frequency, while in the Hx rats this shift had the opposite direction. Read More

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http://dx.doi.org/10.1159/000497224DOI Listing

Golgipathies in Neurodevelopment: A New View of Old Defects.

Dev Neurosci 2019 Mar 15:1-21. Epub 2019 Mar 15.

NeuroDiderot, INSERM UMR1141, Université Paris Diderot, Sorbonne Paris Cité, Paris, France,

The Golgi apparatus (GA) is involved in a whole spectrum of activities, from lipid biosynthesis and membrane secretion to the posttranslational processing and trafficking of most proteins, the control of mitosis, cell polarity, migration and morphogenesis, and diverse processes such as apoptosis, autophagy, and the stress response. In keeping with its versatility, mutations in GA proteins lead to a number of different disorders, including syndromes with multisystem involvement. Intriguingly, however, > 40% of the GA-related genes known to be associated with disease affect the central or peripheral nervous system, highlighting the critical importance of the GA for neural function. Read More

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http://dx.doi.org/10.1159/000497035DOI Listing
March 2019
1 Read

Calbindin-1 Expression in the Hippocampus following Neonatal Hypoxia-Ischemia and Therapeutic Hypothermia and Deficits in Spatial Memory.

Dev Neurosci 2019 Mar 12:1-15. Epub 2019 Mar 12.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA,

Hippocampal injury following neonatal hypoxia-ischemia (HI) leads to memory impairments despite therapeutic hypothermia (TH). In the hippocampus, the expression of calbindin-1 (Calb1), a Ca2+-buffering protein, increases during postnatal development and decreases with aging and neurodegenerative disorders. Since persistent Ca2+ dysregulation after HI may lead to ongoing injury, persistent changes in hippocampal expression of Calb1 may contribute to memory impairments after neonatal HI. Read More

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http://dx.doi.org/10.1159/000497056DOI Listing
March 2019
9 Reads

Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice.

Dev Neurosci 2019 Mar 12:1-16. Epub 2019 Mar 12.

Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado, USA.

The incidence of stroke in children is 2.4 per 100,000 person-years and results in long-term motor and cognitive disability. In ischemic stroke, white matter (WM) is frequently injured, but is relatively understudied compared to grey matter injury. Read More

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http://dx.doi.org/10.1159/000496200DOI Listing
March 2019
3 Reads

The Effect of Antenatal Betamethasone on White Matter Inflammation and Injury in Fetal Sheep and Ventilated Preterm Lambs.

Dev Neurosci 2019 Mar 6:1-11. Epub 2019 Mar 6.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia,

Antenatal administration of betamethasone (BM) is a common antecedent of preterm birth, but there is limited information about its impact on the acute evolution of preterm neonatal brain injury. We aimed to compare the effects of maternal BM in combination with mechanical ventilation on the white matter (WM) of late preterm sheep. At 0. Read More

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http://dx.doi.org/10.1159/000496466DOI Listing
March 2019
3 Reads

HIF1α Signaling in the Endogenous Protective Responses after Neonatal Brain Hypoxia-Ischemia.

Dev Neurosci 2019 Mar 5:1-10. Epub 2019 Mar 5.

Department of Pediatrics, University of California San Francisco, San Francisco, California, USA,

Hypoxia-inducible factor 1α (HIF1α) is a key regulator of oxygen homeostasis, and its target genes mediate adaptive, protective, and pathological processes. The role of HIF1α in neuronal survival is controversial and the brain maturation stage is important in determining its function in brain ischemia or hypoxia-ischemia (HI). In this study, we used neuron-specific HIF1α knockout mice at postnatal day 9 (P9), and immature cortical neurons (days 7-8 in vitro) treated with the HIF1α inhibitor 2-methoxyestradiol (2ME2) or stabilizer dimethyloxalylglycine (DMOG), to examine the function of neuronal HIF1α in neonatal HI in vivo (Vannucci model) and in vitro (oxygen glucose deprivation, OGD). Read More

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https://www.karger.com/Article/FullText/495879
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http://dx.doi.org/10.1159/000495879DOI Listing
March 2019
6 Reads
2.697 Impact Factor

Seizure Susceptibility Correlates with Brain Injury in Male Mice Treated with Hypothermia after Neonatal Hypoxia-Ischemia.

Dev Neurosci 2019 Feb 28:1-10. Epub 2019 Feb 28.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Hypoxic-ischemic encephalopathy is a common neonatal brain injury associated with significant morbidity and mortality despite the administration of therapeutic hypothermia (TH). Neonatal seizures and subsequent chronic epilepsy are frequent in this patient population and current treatments are partially effective. We used a neonatal murine hypoxia-ischemia (HI) model to test whether the severity of hippocampal and cortical injury predicts seizure susceptibility 8 days after HI and whether TH mitigates this susceptibility. Read More

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https://www.karger.com/Article/FullText/496468
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http://dx.doi.org/10.1159/000496468DOI Listing
February 2019
6 Reads

Ferroptosis and Brain Injury.

Dev Neurosci 2019 Feb 28:1-14. Epub 2019 Feb 28.

Department of Biology, Stanford University, Stanford, California, USA,

Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species. Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors of this process. These compounds have been employed to dissect the lethal mechanism and implicate this process in pathological cell death events observed in many tissues, including the brain. Read More

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http://dx.doi.org/10.1159/000496922DOI Listing
February 2019

Strain-Related Differences in Mouse Neonatal Hypoxia-Ischemia.

Dev Neurosci 2019 Feb 28:1-7. Epub 2019 Feb 28.

Department of Pediatrics, University of California San Francisco, San Francisco, California, USA.

Neonatal hypoxic-ischemic brain injury is commonly studied by means of the Vannucci procedure in mice or rats (unilateral common carotid artery occlusion followed by hypoxia). Previously, we modified the postnatal day 7 (P7) rat procedure for use in mice, and later demonstrated that genetic strain strongly influences the degree of brain injury in the P7 mouse model of hypoxia-ischemia (HI). Recently, the P9 or P10 mouse brain was recognized as the developmental equivalent of a term neonatal human brain, rather than P7. Read More

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http://dx.doi.org/10.1159/000495880DOI Listing
February 2019

Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex.

Dev Neurosci 2018 Dec 21:1-16. Epub 2018 Dec 21.

Department of Psychology, University of Illinois, Champaign, Illinois, USA.

Both high-fat diets (HFD) and bisphenol A (BPA), an environmental endocrine disruptor, are prevalent in industrialized societies. Previous studies have detected separate effects of BPA and HFD; however, none have assessed possible interactive effects. Here, pregnant dams consumed 0, 40, or 400 µg BPA/kg/day and were fed either a control (CON; 15. Read More

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http://dx.doi.org/10.1159/000494879DOI Listing
December 2018
3 Reads

Repeated Pediatric Concussions Evoke Long-Term Oligodendrocyte and White Matter Microstructural Dysregulation Distant from the Injury.

Dev Neurosci 2018 22;40(4):358-375. Epub 2018 Nov 22.

Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA,

Concussion or mild traumatic brain injury (mTBI) is often accompanied by long-term behavioral and neuropsychological deficits. Emerging data suggest that these deficits can be exacerbated following repeated injuries. However, despite the overwhelming prevalence of mTBI in children due to falls and sports-related activities, the effects of mTBI on white matter (WM) structure and its development in children have not been extensively examined. Read More

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http://dx.doi.org/10.1159/000494134DOI Listing
March 2019
5 Reads

Intrauterine Growth Restriction and Hyperoxia as a Cause of White Matter Injury.

Dev Neurosci 2018 14;40(4):344-357. Epub 2018 Nov 14.

Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Intrauterine growth restriction (IUGR) is estimated to occur in 5% of pregnancies, with placental insufficiency being the most common cause in developed countries. While it is known that white matter injury occurs in premature infants, the extent of IUGR on white matter injury is less defined in term infants. We used a novel murine model that utilizes a thromboxane A2 (TXA2) analog (U46619), a potent vasoconstrictor, to induce maternal hypertension and mimic human placental insufficiency-induced IUGR to study the white matter. Read More

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https://www.karger.com/Article/FullText/494273
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http://dx.doi.org/10.1159/000494273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292737PMC
March 2019
22 Reads

Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain.

Dev Neurosci 2018 6;40(4):325-336. Epub 2018 Nov 6.

Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, John G. Rangos Research Center, Pittsburgh, Pennsylvania, USA.

Neuroprotective cold-shock proteins (CSPs) are abundant in the normothermic neonatal rodent brain but decrease with advancing neurodevelopmental age and are low or absent in the adult brain. It has not been established if neurodevelopmental age alters the baseline expression of CSPs in the human brain. Here, we tested the hypothesis that protein levels of RNA-binding motif 3 (RBM3), reticulon-3 (RTN3), and cold-induced RNA-binding protein (CIRBP) are abundant in the normothermic developing human brain but low-to-absent in adults. Read More

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https://www.karger.com/Article/FullText/493637
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http://dx.doi.org/10.1159/000493637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311128PMC
March 2019
10 Reads

NFAT5 Has a Job in the Brain.

Dev Neurosci 2018 2;40(4):289-300. Epub 2018 Nov 2.

Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disorder, School of Basic Medical Sciences, Wuhan University, Wuhan, China,

Nuclear factor of activated T cells 5 (NFAT5) has recently been classified as a new member of the Rel family. In addition, there are 5 more well-defined members (NF-κB and NFAT1-4) in the Rel family, which participate in regulating the expression of immune and inflammatory response-related genes. NFAT5 was initially identified in renal medullary cells where it regulated the expression of osmoprotective-related genes during the osmotic response. Read More

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https://www.karger.com/Article/FullText/493789
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http://dx.doi.org/10.1159/000493789DOI Listing
March 2019
40 Reads

Can Functional Polymorphisms in VEGF and MMP Predict Intraventricular Hemorrhage in Extremely Preterm Newborns?

Dev Neurosci 2018 2;40(4):337-343. Epub 2018 Nov 2.

Division of Pediatric Hematology/Oncology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, USA,

Background: The pathophysiology of intraventricular hemorrhage (IVH) is multifactorial. This study attempts to identify genetic and clinical factors contributing to IVH in newborns with a focus on those born ≤28 weeks of gestation.

Methods: This was a prospective study of 382 consecutive newborns admitted to the neonatal intensive care unit. Read More

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https://www.karger.com/Article/FullText/493788
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March 2019
9 Reads

c-Jun N-Terminal Kinase Inhibition Induces Mitochondrial Oxidative Stress and Decreases Survival in Human Neural Stem Progenitors.

Dev Neurosci 2018 18;40(4):312-324. Epub 2018 Oct 18.

Neural stem cells are attracting enormous attention in regenerative medicine due to their ability to self-renew and differentiate into the cell lineages that constitute the central nervous system. However, little is known about the mechanism underlying the regulation of their redox environment, which is essential for homeostatic cellular functions. The redox-modulated c-Jun N-terminal kinases (JNK) are a molecular switch in stress signal transduction and are involved in numerous brain functions. Read More

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http://dx.doi.org/10.1159/000493009DOI Listing
March 2019
3 Reads
2.697 Impact Factor

Brain Diffusion Imaging and Tractography to Distinguish Clinical Severity of Human PLP1-Related Disorders.

Dev Neurosci 2018 27;40(4):301-311. Epub 2018 Sep 27.

Service de Neurologie Pédiatrique et Maladies Métaboliques, Centre de référence des leucodystrophies et leucoencéphalopathies de cause rare, CHU-APHP Robert-Debré, Paris, France.

Aims: We performed quantitative diffusion tensor imaging and brain tractography to distinguish clinical severity in a series of 35 patients with hypomyelinating PLP1-related disorders classified using the Motor Developmental Score according to the best motor function acquired before the age of 5 years and the gross motor function measure (GMFM) at the time of magnetic resonance imaging acquisition.

Methods: We calculated fractional anisotropy and diffusivity values in 26 regions of interest and the numbers of fibers and volumes of hemisphere tractograms. Fiber bundles on tractograms were characterized according to 3 criteria: size, direction of main-stream fibers, and connectivity of bundles (extratelencephalic projections, commissural fibers, and intrahemispheric connections). Read More

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http://dx.doi.org/10.1159/000492218DOI Listing
March 2019
6 Reads
2.700 Impact Factor

Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2.

Dev Neurosci 2018 18;40(3):278-287. Epub 2018 Sep 18.

Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Aichi, Japan.

MACRO Domain Containing 2 (MacroD2) is a neurodevelopmental disorder-related mono-ADP-ribosylhydrolase. Molecular features of this protein in neural tissues are largely unknown. In this study, we generated a specific antibody against MacroD2, and carried out expression and morphological analyses of the molecule during mouse brain development. Read More

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http://dx.doi.org/10.1159/000492271DOI Listing
January 2019
2 Reads

Validation of Raised Cord Blood Interleukin-16 in Perinatal Asphyxia and Neonatal Hypoxic-Ischaemic Encephalopathy in the BiHiVE2 Cohort.

Dev Neurosci 2018 11;40(3):271-277. Epub 2018 Sep 11.

Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork, Ireland.

The role of inflammation is an important factor in the progression of hypoxic-ischaemic encephalopathy (HIE). We have previously shown that interleukin-16 (IL-16) is increased in infants with moderate and severe HIE and relates to poor neurodevelopmental outcomes. We aimed to validate IL-16 as a cord blood-based biomarker for HIE and to examine its relationship to long-term outcomes. Read More

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http://dx.doi.org/10.1159/000491386DOI Listing
January 2019
3 Reads

Human Umbilical Cord Blood Therapy Protects Cerebral White Matter from Systemic LPS Exposure in Preterm Fetal Sheep.

Dev Neurosci 2018 4;40(3):258-270. Epub 2018 Sep 4.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

Background: Infants born preterm following exposure to in utero inflammation/chorioamnionitis are at high risk of brain injury and life-long neurological deficits. In this study, we assessed the efficacy of early intervention umbilical cord blood (UCB) cell therapy in a large animal model of preterm brain inflammation and injury. We hypothesised that UCB treatment would be neuroprotective for the preterm brain following subclinical fetal inflammation. Read More

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http://dx.doi.org/10.1159/000490943DOI Listing
January 2019
11 Reads

Different Developmental Pattern of Brain Activities in ADHD: A Study of Resting-State fMRI.

Dev Neurosci 2018 13;40(3):246-257. Epub 2018 Jul 13.

There are distinct symptoms for attention deficit hyperactivity disorder (ADHD) at different ages. To explore the developmental mechanism of ADHD from childhood to adolescence, patients from different age groups with ADHD drawn from a large dataset should be investigated. In this study, we hypothesized that there are significant differences in the developmental patterns of local and global brain activities between ADHD and typically developing (TD) individuals. Read More

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https://www.karger.com/Article/FullText/490289
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http://dx.doi.org/10.1159/000490289DOI Listing
January 2019
12 Reads

Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain.

Dev Neurosci 2018 26;40(3):234-245. Epub 2018 Jul 26.

Hypoxic-ischemic brain injury is a leading cause of neurodevelopmental morbidities in preterm and full-term infants. Blood-brain barrier dysfunction represents an important component of perinatal hypoxic-ischemic brain injury. The extracellular matrix (ECM) is a vital component of the blood-brain barrier. Read More

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http://dx.doi.org/10.1159/000489700DOI Listing
January 2019
3 Reads

Egr-1 Maintains NSC Proliferation and Its Overexpression Counteracts Cell Cycle Exit Triggered by the Withdrawal of Epidermal Growth Factor.

Dev Neurosci 2018 5;40(3):223-233. Epub 2018 Jul 5.

Dipartimento di Biologia e Biotecnologie "Charles Darwin", Unità di Ricerca in Neurobiologia e Centro di Ricerca in Neurobiologia "Daniel Bovet", Sapienza Università di Roma, Rome, Italy.

In adult mammals, neural stem cells (NSCs) reside in specialized niches at the level of selected CNS regions, such as the subventricular zone (SVZ). The signaling pathways that reg-ulate NSC proliferation and differentiation remain poorly understood. Early growth response protein 1 (Egr-1) is an important transcription factor, widely studied in the adult mammalian brain, mediating the activation of target genes by a variety of extracellular stimuli. Read More

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http://dx.doi.org/10.1159/000489699DOI Listing
January 2019
14 Reads

The Relationship between White Matter and Reading Acquisition, Refinement and Maintenance.

Dev Neurosci 2018 25;40(3):209-222. Epub 2018 Jun 25.

Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.

Reading requires efficient communication between brain regions that are situated all over the cortex. These brain areas are structurally connected by white-matter pathways that develop over the period of reading acquisition. Here, we conducted a cross-sectional study to assess the relationship between white-matter tracts and reading performance across the lifespan. Read More

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http://dx.doi.org/10.1159/000489491DOI Listing
January 2019
2 Reads

Brain Barrier Disruption and Region-Specific Neuronal Degeneration during Necrotizing Enterocolitis in Preterm Pigs.

Dev Neurosci 2018 6;40(3):198-208. Epub 2018 Jun 6.

Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark.

Necrotizing enterocolitis (NEC) increases the risk of brain injury and impaired neurodevelopment. Rapid brain maturation prior to birth may explain why preterm brains are particularly vulnerable to serious infections. Using pigs as models, we hypothesized that preterm birth was associated with altered blood-cerebrospinal fluid (CSF) barrier (BCSFB) function and cerebral structural deficits, and that NEC was associated with systemic inflammation, BCSFB disruption, and neuroinflammation. Read More

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http://dx.doi.org/10.1159/000488979DOI Listing
January 2019
2 Reads

Hypothermia Is Neuroprotective after Severe Hypoxic-Ischaemic Brain Injury in Neonatal Rats Pre-Exposed to PAM3CSK4.

Dev Neurosci 2018 1;40(3):189-197. Epub 2018 Jun 1.

Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Background: Preclinical research on the neuroprotective effect of hypothermia (HT) after perinatal asphyxia has shown variable results, depending on comorbidities and insult severity. Exposure to inflammation increases vulnerability of the neonatal brain to hypoxic-ischaemic (HI) injury, and could be one explanation for those neonates whose injury is unexpectedly severe. Gram-negative type inflammatory exposure by lipopolysaccharide administration prior to a mild HI insult results in moderate brain injury, and hypothermic neuroprotection is negated. Read More

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http://dx.doi.org/10.1159/000487798DOI Listing
January 2019
2 Reads

Juvenile Traumatic Brain Injury Results in Cognitive Deficits Associated with Impaired Endoplasmic Reticulum Stress and Early Tauopathy.

Dev Neurosci 2018 22;40(2):175-188. Epub 2018 May 22.

Department of Neurosurgery, West Virginia University School of Medicine, Morgantown, West Virginia, USA.

The leading cause of death in the juvenile population is trauma, and in particular neurotrauma. The juvenile brain response to neurotrauma is not completely understood. Endoplasmic reticulum (ER) stress has been shown to contribute to injury expansion and behavioral deficits in adult rodents and furthermore has been seen in adult postmortem human brains diagnosed with chronic traumatic encephalopathy. Read More

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http://dx.doi.org/10.1159/000488343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376969PMC
November 2018
3 Reads

Intrauterine Growth Restriction Affects Cerebellar Granule Cells in the Developing Guinea Pig Brain.

Dev Neurosci 2018 15;40(2):162-174. Epub 2018 May 15.

Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Victoria, Australia.

Intrauterine growth restriction (IUGR) can lead to adverse neurodevelopmental sequelae in postnatal life. However, the effects of IUGR on the cerebellum are still to be fully elucidated. A major determinant of growth and development of the cerebellum is proliferation and subsequent migration of cerebellar granule cells. Read More

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http://dx.doi.org/10.1159/000487797DOI Listing
November 2018
2 Reads

Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone.

Dev Neurosci 2018 20;40(2):145-161. Epub 2018 Apr 20.

Department of Anatomy and Medical Imaging, Faculty of Medical and Health Science, University of Auckland, Auckland, New Zealand.

Fatty acid-binding proteins (FABPs) are a family of transport proteins that facilitate intracellular transport of fatty acids. Despite abundant expression in the brain, the role that FABPs play in the process of cell proliferation and migration in the subventricular zone (SVZ) remains unclear. Our results provide a detailed characterisation of FABP3, 5, and 7 expression in adult and fetal human and sheep SVZ. Read More

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http://dx.doi.org/10.1159/000487633DOI Listing
November 2018
6 Reads

High Concentration of Glial Cell Line-Derived Neurotrophic Factor Protects Primary Astrocytes from Apoptosis.

Dev Neurosci 2018 13;40(2):134-144. Epub 2018 Apr 13.

Department of Neurobiology, Xuzhou Key Laboratory of Neurobiology, Xuzhou Medical University, Xuzhou, China.

Background: Studies have shown that astrocytes play an important role in a variety of biological processes, so damage to astrocytes can cause a series of related diseases. Glial cell line-derived neurotrophic factor (GDNF) has always been considered a protective factor for dopamine neurons. However, it remains unclear whether GDNF has a protective effect on glial cells, especially astrocytes. Read More

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http://dx.doi.org/10.1159/000487853DOI Listing
November 2018
3 Reads

Cranial Irradiation Induces Hypothalamic Injury and Late-Onset Metabolic Disturbances in Juvenile Female Rats.

Dev Neurosci 2018 10;40(2):120-133. Epub 2018 Apr 10.

Henan Key Laboratory of Child Brain Injury, Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Cranial radiotherapy is one of the most effective tools for treating children with brain tumors. However, radiotherapy-induced late-onset side effects have a significant impact on patients' quality of life. The purpose of this study was to investigate the effects of irradiation on metabolism and the possible molecular and cellular mechanisms behind such effects. Read More

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http://dx.doi.org/10.1159/000487923DOI Listing
November 2018
10 Reads

Altered Hippocampal Gene Expression and Morphology in Fetal Piglets following Maternal Respiratory Viral Infection.

Dev Neurosci 2018 14;40(2):104-119. Epub 2018 Mar 14.

Department of Animal Sciences, Laboratory of Integrative Immunology and Behavior, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.

Maternal infection during pregnancy increases the risk of neurobehavioral problems in offspring. Evidence from rodent models indicates that the maternal immune response to infection can alter fetal brain development, particularly in the hippocampus. However, information on the effects of maternal viral infection on fetal brain development in gyrencephalic species is limited. Read More

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http://dx.doi.org/10.1159/000486850DOI Listing
November 2018
5 Reads

Neonatal Stress Has a Long-Lasting Sex-Dependent Effect on Anxiety-Like Behavior and Neuronal Morphology in the Prefrontal Cortex and Hippocampus.

Dev Neurosci 2018 22;40(2):93-103. Epub 2018 Feb 22.

Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alabama, Canada.

The long-lasting effects of early stress on brain development have been well studied. Recent evidence indicates that males and females respond differently to the same stressor. We examined the chronic effects of daily maternal separation (MS) on behavior and cerebral morphology in both male and female rats. Read More

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http://dx.doi.org/10.1159/000486619DOI Listing
November 2018
4 Reads

Exogenous β-Hydroxybutyrate Treatment and Neuroprotection in a Suckling Rat Model of Hypoxic-Ischemic Encephalopathy.

Dev Neurosci 2018 21;40(1):73-83. Epub 2018 Feb 21.

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

β-Hydroxybutyrate (BHB) is a representative ketone body that may play a role in the mitigation of neonatal hypoxic-ischemic encephalopathy by altering energy metabolism. This study aimed to investigate the neuroprotective efficacy of exogenous BHB administration in a suckling rat model after hypoxia-ischemia (HI). Thirteen-day-old (P13) rat pups were subjected to 120 min of hypoxia according to the Rice-Vannucci model. Read More

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http://dx.doi.org/10.1159/000486411DOI Listing
October 2018
12 Reads

Effects of Environmental Enrichment on Nicotine Sensitization in Rats Neonatally Treated with Quinpirole: Analyses of Glial Cell Line-Derived Neurotrophic Factor and Implications towards Schizophrenia.

Dev Neurosci 2018 14;40(1):64-72. Epub 2018 Feb 14.

Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.

The current study analyzed the effects of environmental enrichment versus isolation housing on the behavioral sensitization to nicotine in the neonatal quinpirole (NQ; dopamine D2-like agonist) model of dopamine D2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats increases dopamine D2 receptor sensitivity throughout the animal's lifetime, consistent with schizophrenia. Animals were administered NQ (1 mg/kg) or saline (NS) from postnatal day (P)1 to P21, weaned, and immediately placed into enriched housing or isolated in wire cages throughout the experiment. Read More

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http://dx.doi.org/10.1159/000486391DOI Listing
October 2018
6 Reads

Magnesium as a Neuroprotective Agent: A Review of Its Use in the Fetus, Term Infant with Neonatal Encephalopathy, and the Adult Stroke Patient.

Dev Neurosci 2018 7;40(1):1-12. Epub 2018 Feb 7.

Institute for Women's Health, London, UK.

Magnesium is an intracellular cation essential for many en-zymatic processes and cellular functions. Magnesium sulfate acts as an endogenous calcium channel antagonist at neuronal synapses, thought to prevent excessive activation of N-methyl-D-aspartate receptors by excitatory amino acids, such as glutamate, and by downregulation of proinflammatory pathways. Early intervention is essential in the prevention of the secondary phase of neuronal injury. Read More

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http://dx.doi.org/10.1159/000484891DOI Listing
October 2018
9 Reads

Microglial Activation Induces Generation of Oligodendrocyte Progenitor Cells from the Subventricular Zone after Focal Demyelination in the Corpus Callosum.

Dev Neurosci 2018 25;40(1):54-63. Epub 2018 Jan 25.

Department of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Neuroblasts derived from neural stem cells (NSCs) in the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb to generate interneurons under normal physiological conditions. When demyelination occurs, NSCs or neural progenitor cells (NPCs) in the SVZ provide newly formed oligodendrocytes to demyelinated lesions. The plasticity of NSC/NPC lineages may tend to oligodendrogenesis under the influence of demyelinated lesions. Read More

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http://dx.doi.org/10.1159/000486332DOI Listing
October 2018
4 Reads

Distribution and Cellular Localization of KCC2 in the Ferret Neocortex.

Dev Neurosci 2018 31;40(1):39-53. Epub 2018 Jan 31.

KCC2 (a brain-specific potassium-chloride cotransporter) affects development of the cerebral cortex, including aspects of neuronal migration and cellular maturation and differentiation. KCC2 also modulates chloride homeostasis by influencing the switch of GABA from depolarizing in young neurons to hyperpolarizing in mature neurons. We describe the expression pattern, regional distribution, and cellular colocalization of KCC2 in the ferret cortex in normal kits and those treated with methylazoxymethanol acetate (MAM). Read More

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http://dx.doi.org/10.1159/000485076DOI Listing
October 2018
5 Reads

Targeted Knockdown of Bone Morphogenetic Protein Signaling within Neural Progenitors Protects the Brain and Improves Motor Function following Postnatal Hypoxia-Ischemia.

Dev Neurosci 2018 12;40(1):23-38. Epub 2018 Jan 12.

Developmental Biology Program, Stanley Manne Children's Research Institute, Chicago, IL, USA.

Hypoxic-ischemic injury (HI) to the neonatal human brain results in myelin loss that, in some children, can manifest as cerebral palsy. Previously, we had found that neuronal overexpression of the bone morphogenic protein (BMP) inhibitor noggin during development increased oligodendroglia and improved motor function in an experimental model of HI utilizing unilateral common carotid artery ligation followed by hypoxia. As BMPs are known to negatively regulate oligodendroglial fate specification of neural stem cells and alter differentiation of committed oligodendroglia, BMP signaling is likely an important mechanism leading to myelin loss. Read More

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http://dx.doi.org/10.1159/000485379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861030PMC
October 2018
7 Reads

Effects of Early-Life Adversity on Hippocampal Structures and Associated HPA Axis Functions.

Dev Neurosci 2018 14;40(1):13-22. Epub 2017 Dec 14.

Division of Psychology and Language Sciences, University College London, London, UK.

Early-life adversity (ELA) is one of the major risk factors for serious mental and physical health risks later in life. ELA has been associated with dysfunctional neurodevelopment, especially in brain structures such as the hippocampus, and with dysfunction of the stress system, including the hypothalamic-pituitary-adrenal (HPA) axis. Children who have experienced ELA are also more likely to suffer from mental health disorders such as depression later in life. Read More

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http://dx.doi.org/10.1159/000484238DOI Listing
October 2018
13 Reads

Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study.

Dev Neurosci 2018 8;40(1):84-92. Epub 2017 Dec 8.

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Neuropsychiatric disorders that frequently initially emerge during adolescence are associated with deficits in the omega-3 (n-3) fatty acid docosahexaenoic acid (DHA), elevated proinflammatory signaling, and regional reductions in white matter integrity (WMI). This study determined the effects of altering brain DHA accrual during adolescence on WMI in the rat brain by diffusion tensor imaging (DTI), and investigated the potential mediating role of proinflammatory signaling. During periadolescent development, male rats were fed a diet deficient in n-3 fatty acids (DEF, n = 20), a fish oil-fortified diet containing preformed DHA (FO, n = 20), or a control diet (CON, n = 20). Read More

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http://dx.doi.org/10.1159/000484554DOI Listing
October 2018
7 Reads

Maternal Cannabinoid Use Alters Cannabinoid (CB1) and Endothelin (ETB) Receptor Expression in the Brains of Dams but Not Their Offspring.

Dev Neurosci 2017 4;39(6):498-506. Epub 2017 Nov 4.

Division of Neonatology, Department of Pediatrics, Advocate Children's Hospital, Park Ridge, IL, USA.

According to the 2015 National Survey on Drug Use and Health, cannabis (marijuana) is the most commonly used recreational drug in the US. Among pregnant women aged 14-55 years, 3.4% were cannabis users. Read More

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http://dx.doi.org/10.1159/000480453DOI Listing
September 2018
8 Reads

Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.

Dev Neurosci 2017 28;39(6):519-528. Epub 2017 Oct 28.

Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

The kynurenine pathway (KP), the major catabolic route of tryptophan in mammals, contains several neuroactive metabolites, including kynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK). KP metabolism, and especially the fate of KYNA, during pregnancy is poorly understood, yet it may play a significant role in the development of psychiatric disorders later in life. The present study was designed to investigate the prenatal features of KP metabolism in vivo, with special focus on KYNA. Read More

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http://dx.doi.org/10.1159/000481168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338215PMC
September 2018
33 Reads

Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder.

Dev Neurosci 2017 27;39(6):507-518. Epub 2017 Oct 27.

Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.

Prenatal exposure to the antiepileptic, mood-stabilizing drug, valproic acid (VPA), increases the incidence of autism spectrum disorders (ASDs); in utero administration of VPA to pregnant rodents induces ASD-like behaviors such as repetitive, stereotyped activity, and decreased socialization. In both cases, males are more affected than females. We previously reported that VPA, administered to pregnant mice at gestational day 12. Read More

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http://dx.doi.org/10.1159/000481134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020162PMC
September 2018
11 Reads