399,619 results match your criteria Developmental Epidemiology [Journal]


Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm.

Early Hum Dev 2018 Dec 3;128:48-54. Epub 2018 Dec 3.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Objective: To evaluate the relationship of parent-reported child behaviors on the Child Behavior Checklist (CBCL) to cognition, language, and motor skills on the Bayley Scales of Infant and Toddler Development - III (Bayley-III) in toddlers born extremely preterm.

Study Design: Toddlers born extremely preterm (gestational ages 22 0/7 to 26 6/7 weeks) were tested at 22-26 months corrected age with Bayley-III while parents completed the CBCL. Socio-demographic variables and medical history were recorded. Read More

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December 2018
2 Reads

A systematic review of sudden unexpected death in epilepsy (SUDEP) in childhood.

Epilepsy Behav 2018 Dec 3;90:99-106. Epub 2018 Dec 3.

Population, Policy and Practice Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a significant cause of death in childhood epilepsy, and causes considerable concern to patients and their families. Despite this, the condition remains poorly understood. This systematic review investigates the risk factors, pathophysiology, and circumstances associated with childhood SUDEP. Read More

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December 2018
5 Reads

Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.

J Proteomics 2018 Dec 3. Epub 2018 Dec 3.

Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Major depressive disorders impact approximately 17% of the population worldwide, whose high morbidity and considerable adversity have resulted in enormous social and economic burden. In addition, clinically depressed patients often show reduced volume of olfactory bulb (OB) and decreased olfactory sensitivity. Although mounting evidence conveyed that the gut microbiota may implicate the pathophysiology of major depressive disorder (MDD) via the microbe-gut-brain axis, knowledge about its distinctive molecular mechanism is rudimentary. Read More

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December 2018
1 Read

Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Lipid homeostasis is important for executing normal cellular functions and maintaining physiological conditions. The biophysical properties and intricate metabolic network of lipids underlie the coordinated regulation of different lipid species in lipid homeostasis. To reveal the homeostatic response among different lipids, we systematically knocked down 40 lipid metabolism genes in Drosophila S2 cells by RNAi and profiled the lipidomic changes. Read More

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December 2018

22kHz and 55kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat.

Behav Brain Res 2018 Dec 3. Epub 2018 Dec 3.

Developmental Neuropsychobiology Lab, Department of Psychology, Northeastern University, 360 Huntington Ave NI125, Boston, MA, 02115, United States. Electronic address:

The communicative role of ultrasonic vocalizations (USVs) in rats is well established, with distinct USVs indicative of different affective states. USVs in the 22 kHz range are typically emitted by adult rats when in anxiety- or fear-provoking situations (e.g. Read More

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December 2018

Structural characterization, teratogenicity and in vitro avian antimicrobial activity of posterior salivary gland (PSG) toxin from cuttlefish, Sepia prashadi.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Native Medicine and Marine Pharmacology Laboratory, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, Chennai 603 103, Tamil Nadu, India. Electronic address:

A low molecular weight posterior salivary gland (PSG) toxin was isolated and purified from the cuttlefish Sepia prashadi by Reverse Phase High Performance Liquid Chromatography (RP-HPLC). The protein and neutral sugar content of the PSG toxin was determined to be 1.033 mg/g and 282 μg/g. Read More

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December 2018

Cellular and Molecular Mechanisms of Regeneration in colonial and solitary Ascidians.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA USA.

Regenerative ability is highly variable among the metazoans. While many invertebrate organisms are capable of complete regeneration of entire bodies and organs, whole-organ regeneration is limited to very few species in the vertebrate lineages. Tunicates, which are invertebrate chordates and the closest extant relatives of the vertebrates, show robust regenerative ability. Read More

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December 2018
2 Reads

Massive cytoplasmic transport and microtubule organization in fertilized chordate eggs.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Research Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido 001-0020, Japan.

Eggs have developed their own strategies for early development. Amphibian, teleost fish, and ascidian eggs show cortical rotation and an accompanying structure, a cortical parallel microtubule (MT) array, during the one-cell embryonic stage. Cortical rotation is thought to relocate maternal deposits to a certain compartment of the egg and to polarize the embryo. Read More

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December 2018
2 Reads

Expression of the neuropeptides RFamide and LWamide during development of the coral Acropora millepora in relation to settlement and metamorphosis.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Division of Ecology and Evolution, Bldg 46, Research School of Biology, Australian National University, Canberra, ACT 0200, Australia; ARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville, QLD 4811, Australia. Electronic address:

Neuropeptides play critical roles in cnidarian development. However, although they are known to play key roles in settlement and metamorphosis, their temporal and spatial developmental expression has not previously been characterized in any coral. We here describe Acropora millepora LWamide and RFamide and their developmental expression from the time of their first appearance, using in situ hybridization and FMRFamide immunohistochemistry. Read More

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December 2018
1 Read

Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage.

Dev Biol 2018 Dec 3. Epub 2018 Dec 3.

Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, 94143, USA. Electronic address:

MEF2C is a member of the highly conserved MEF2 family of transcription factors and is a key regulator of cardiovascular development. In mice, Mef2c is expressed in the developing heart and vasculature, including the endothelium. Loss of Mef2c function in germline knockout mice leads to early embryonic demise and profound developmental abnormalities in the cardiovascular system. Read More

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December 2018

Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5773-5784

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: The optic fissure (OF) is a transient opening in the ventral optic cup (OC) that acts as a passage for blood vessels and retinal ganglion cell axons during early eye development. Failure to close the OF is the developmental basis for uveal coloboma, a congenital blinding eye disease that significantly contributes to childhood blindness. Genes specifically expressed in the OF region may play important roles in OF development and function. Read More

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December 2018

The Development of American Sign Language-Based Analogical Reasoning in Signing Deaf Children.

J Speech Lang Hear Res 2018 Dec 6:1-13. Epub 2018 Dec 6.

Center for Research and Training, Framingham, MA.

Purpose: This article examines whether syntactic and vocabulary abilities in American Sign Language (ASL) facilitate 6 categories of language-based analogical reasoning.

Method: Data for this study were collected from 267 deaf participants, aged 7;6 (years;months) to 18;5. The data were collected from an ongoing study initially funded by the U. Read More

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December 2018

Magnetic resonance imaging quantification of dehydration and rehydration in vocal fold tissue layers.

PLoS One 2018 6;13(12):e0208763. Epub 2018 Dec 6.

Division of Otolaryngology, Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Clinicians commonly recommend increased hydration to patients with voice disorders. However, effects on clinical voice outcome measures have been inconsistent. Hydration-induced change within different layers of vocal fold tissue is currently unknown. Read More

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December 2018
1 Read

Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.

PLoS One 2018 6;13(12):e0208321. Epub 2018 Dec 6.

Cardiovascular Research Program, VA New York Harbor Healthcare System, Brooklyn, New York, United States of America.

Increased proinflammatory interleukin-6 (IL-6) levels are associated with acquired long QT-syndrome (LQTS) in patients with systemic inflammation, leading to higher risks for life-threatening polymorphic ventricular tachycardia such as Torsades de Pointes. However, the functional and molecular mechanisms of this association are not known. In most cases of acquired LQTS, the target ion channel is the human ether-á-go-go-related gene (hERG) encoding the rapid component of the delayed rectifier K current, IKr, which plays a critical role in cardiac repolarization. Read More

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December 2018
1 Read

Polyphenol enriched ethanolic extract of Cajanus scarabaeoides (L.) Thouars exerts potential antifilarial activity by inducing oxidative stress and programmed cell death.

PLoS One 2018 6;13(12):e0208201. Epub 2018 Dec 6.

Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan, India.

Development of antifilarial drug from the natural sources is considered as one of the most efficacious, safe, and affordable approaches. In this study, we report the antifilarial activity of a leguminous plant Cajanus scarabaeoides (L.) Thouars. Read More

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December 2018
2 Reads

Tissue Specificity in Trisomy 22 Mosaicism: A Tale of Caution for Interpretation of Chromosomal Microarray Results.

J Assoc Genet Technol 2018 ;44(4):137-140

Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT.

Objectives: While the complete form of trisomy 22 is seemingly incompatible with life, the mosaic form is a rare syndrome associated with developmental delays, intellectual disability, and dysmorphic features. Due in part to the difficulty of analyzing chromosomal mosaicism, many instances either go undiagnosed or have their diagnosis delayed. We report a case of mosaic trisomy 22 in a diamnionic-dichorionic twin with marked growth discordance and intra-uterine growth restriction, diagnosed in a 2-year-old with developmental delays, sensorineural hearing loss, cardiac and gastrointestinal abnormalities, and osteopenia of prematurity. Read More

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January 2018
6 Reads

Pancreas divisum: a reemerging risk factor for pancreatic diseases.

Authors:
Serghei Covantev

Rom J Intern Med 2018 Dec;56(4):233-242

Laboratory of Allergology and Clinical Immunology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.

Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. Read More

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December 2018
1 Read

Application of resilience theories in the transition to parenthood: a scoping review.

J Reprod Infant Psychol 2018 Dec 6:1-22. Epub 2018 Dec 6.

a School of Psychology , The University of Adelaide , Adelaide , Australia.

Objective: Investigate the use of resilience theories in the transition to parenthood literature.

Background: The transition to parenthood is a key developmental experience for many adults. Resilience is a unifying theoretical concept which incorporates many of the skills and resources linked with the transition to parenthood, but the uptake of resilience theory in this literature is unknown. Read More

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December 2018
2 Reads

Children's Facial Emotion Recognition Skills: Longitudinal Associations With Lateralization for Emotion Processing.

Child Dev 2018 Dec 6. Epub 2018 Dec 6.

Royal Holloway, University of London.

This is the first longitudinal study to evaluate the relations between hemispheric laterality for emotion processing and the development of facial emotion recognition (FER) skills, both of which show similar developmental trajectories. Five to 12-year-old children (N = 160) completed an emotion discrimination task, emotion matching task, identity matching task, and behavioral lateralization for emotion processing task at baseline and 1 year later. Lateralization at baseline predicted later emotion discrimination, whereas change in strength of lateralization across the year predicted emotion matching ability. Read More

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December 2018

Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Institute of Cell Biology and Genes and Development Group, CDBS Hugh Robson Building, University of Edinburgh, Edinburgh, UK.

Study Question: Does ovarian follicle activation by phosphatase homologue of chromosome-10 (PTEN) inhibition affect DNA damage and repair in bovine oocytes and granulosa cells?

Summary Answer: PTEN inhibition promotes bovine non-growing follicle activation but results in increased DNA damage and impaired DNA repair capacity in ovarian follicles in vitro.

What Is Known Already: Inhibition of PTEN is known to activate primordial follicles but may compromise further developmental potential. In breast cancer cells, PTEN inhibition represses nuclear translocation of breast cancer susceptibility 1 (BRCA1) and Rad51; this impairs DNA repair resulting in an accumulation of damaged DNA, which contributes to cell senescence. Read More

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December 2018

Concurrent Developmental Course of Sleep Problems and Emotional/behavioral Problems in Childhood and Adolescence as Reflected by the Dysregulation Profile.

Sleep 2018 Dec 6. Epub 2018 Dec 6.

Centre and Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, The University of Western Australia, Perth, WA, Australia.

Objectives: Longitudinal data on the course and relationship of concurrent psychopathology in youth are scarce but are of need for better practical patient care and prevention. This study explores the course of (and relationships over time) between sleep problems and concurrent dimensional difficulties relating to anxiety/depression, attention deficiency and aggressive behaviors in childhood and adolescence. The latter three may jointly form a broad syndrome, the dysregulation profile. Read More

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December 2018

Histones Predate the Split Between Bacteria and Archaea.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany.

Motivation: Histones form octameric complexes called nucleosomes, which organize the genomic DNA of eukaryotes into chromatin. Each nucleosome comprises two copies each of the histones H2A, H2B, H3, and H4, which share a common ancestry. Although histones were initially thought to be a eukaryotic innovation, the subsequent identification of archaeal homologs led to the notion that histones emerged before the divergence of archaea and eukaryotes. Read More

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December 2018
6 Reads

Control of neural crest multipotency by Wnt signaling and the Lin28/ axis.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Molecular Biology and Genetics,, Cornell University, Ithaca, United States.

A crucial step in cell differentiation is the silencing of developmental programs underlying multipotency. While much is known about how lineage-specific genes are activated to generate distinct cell types, the mechanisms driving suppression of stemness are far less understood. To address this, we examined the regulation of the transcriptional network that maintains progenitor identity in avian neural crest cells. Read More

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December 2018
1 Read

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

Pathways modulating glucose homeostasis independently of insulin would open new avenues to combat insulin resistance and diabetes. Here, we report the establishment, characterization and use of a vertebrate 'insulin-free' model to identify insulin-independent modulators of glucose metabolism. knockout zebrafish recapitulate core characteristics of diabetes and survive only up to larval stages. Read More

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December 2018

Protein gradients on the nucleoid position the carbon-fixing organelles of cyanobacteria.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Biochemistry, Michigan State University, East Lansing, United States.

Carboxysomes are protein-based bacterial organelles encapsulating key enzymes of the Calvin-Benson-Bassham cycle. Previous work has implicated a ParA-like protein (hereafter McdA) as important for spatially organizing carboxysomes along the longitudinal axis of the model cyanobacterium PCC 7942. Yet, how self-organization of McdA emerges and contributes to carboxysome positioning is unknown. Read More

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December 2018
1 Read

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, United States.

The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etoposide reveals a profound dysregulation of the DNA damage response, including upstream regulators and downstream p53 targets. Read More

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December 2018

Regulating Osteogenic Differentiation by Suppression of Exosomal microRNAs.

Tissue Eng Part A 2018 Dec 6. Epub 2018 Dec 6.

Kyungpook National University, Oral Microbiology , 2177 Dalgubeol-daero, Jung-gu , Daegu, Korea, Republic of , 41940 ;

Exosomes are membranous nanovesicles that naturally transport bio-molecules, including miRNAs, and play critical roles in intercellular communication. We found that the growth condition milieu of pre-osteoblast exosomes contains a high level of the let-7 miRNAs. After blocking exosome secretion, we found that osteogenic differentiation of pre-osteoblasts (MC3T3-E1 cells) decreased significantly whereas addition of exosomes from growth condition recovered osteogenic ability. Read More

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December 2018
1 Read

High Humidity and Age-Dependent Fruit Susceptibility Promote Development of Trichothecium Black Spot on Apple.

Plant Dis 2018 Dec 6:PDIS05180734RE. Epub 2018 Dec 6.

State Key Laboratory of Crop Stress Biology in Arid Areas and College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Fruit bagging is a widely used orchard practice in China. Trichothecium black spot (TBS) is a disease highly associated with the fruit bagging. In this study, we characterized in vitro factors affecting the causal agent, Trichothecium roseum, and TBS development and infection histology on field-bagged apple fruit in situ. Read More

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December 2018

Spiteful and contemptuous: A new look at the emotional experiences related to psychopathy.

Personal Disord 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, University of California, San Diego.

Psychopathy has long been conceptualized in terms of an absence of emotion. Yet, recent studies have suggested that the experience of other-directed negative emotions may be more intimately linked to psychopathy than previously acknowledged, although there is limited knowledge concerning the experience of such emotions. The present study examined the disposition to experience two other-directed emotions, spitefulness and contempt, that are conceptually linked with psychopathy but currently are limited in empirical support. Read More

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December 2018
1 Read

Role of FGF signalling in neural crest cell migration during early chick embryo development.

Zygote 2018 Dec 6:1-8. Epub 2018 Dec 6.

1Department of Histology and Embryology, International Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College,Jinan University,Guangzhou 510632,China.

SummaryFibroblast growth factor (FGF) signalling acts as one of modulators that control neural crest cell (NCC) migration, but how this is achieved is still unclear. In this study, we investigated the effects of FGF signalling on NCC migration by blocking this process. Constructs that were capable of inducing Sprouty2 (Spry2) or dominant-negative FGFR1 (Dn-FGFR1) expression were transfected into the cells making up the neural tubes. Read More

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December 2018

Follicular Development and Reproductive Characteristics in Four Species of Brazilian Tropidurus Lizards.

Zoolog Sci 2018 Dec;35(6):553-563

4 Biology Institute, State University of Campinas. Monteiro Lobato st., 255 - Cidade Universitária, Campinas, São Paulo 13083-862, Brazil.

The follicular development and reproductive characteristics of four species of oviparous lizards in the Tropidurus torquatus group were anatomically and histologically evaluated. We measured specimens, recorded the number of follicles and eggs, and removed the right ovary of each individual, which we processed according to histological routine and photo-documented. For all species, ovaries were divided into a cortical germinal bed, where oogonia and stage I oocytes are located, and a medullar stroma, where the remaining follicular developmental stages occur. Read More

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December 2018

Total Non-Consumptive Effects of Fish on Pelobates fuscus and Hyla orientalis Tadpoles in Pond Enclosure Experiments.

Zoolog Sci 2018 Dec;35(6):528-534

Institute of Zoology, Poznań University of Life Sciences, Wojska Polskiego 71C, 60-625 Poznań, Poland.

Most research on non-consumptive predator effects on amphibian larvae has been conducted in laboratory or mesocosm designs. Here, Pelobates fuscus and Hyla orientalis tadpoles were separately exposed to non-lethal (free-moving, but with tied mouthparts) common carp Cyprinus carpio for one week in enclosures placed in a pond densely stocked with fish. Tadpoles exposed to nonlethal fish did not differ in mortality, body mass, or, except for deeper tail fin depth in P. Read More

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December 2018

Disruption of sex-specific doublesex exons results in male- and female-specific defects in the black cutworm, Agrotis ipsilon.

Pest Manag Sci 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.

Background: Doublesex (dsx), the downstream gene in the insect sex determination pathway, is a key regulator of sexually dimorphic development and behavior across a variety of insects. Manipulating the expression of dsx could be a useful method in genetic control of insects. However, information on the sex-specific function of dsx in non-model insects is lacking. Read More

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December 2018
1 Read

Extensive branching of radially-migrating neurons in the mammalian cerebral cortex.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Instituto de Neurociencias, Agencia Estatal Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, San Juan de Alicante, Spain.

Excitatory neurons of the cerebral cortex migrate radially from their place of birth to their final position in the cortical plate during development. Radially-migrating neurons display a single leading process that establishes the direction of movement. This leading process has been described as being unbranched, and the occurrence of branches proposed to impair radial migration. Read More

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December 2018
1 Read

Nervous system characterization during the development of a basal echinoderm, the feather star Antedon mediterranea.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Environmental Science and Policy, Università degli Studi di Milano, Milano, Italy.

Neural development of echinoderms has always been difficult to interpret, as larval neurons degenerate at metamorphosis and a tripartite nervous system differentiates in the adult. Despite their key phylogenetic position as basal echinoderms, crinoids have been scarcely studied in developmental research. However, since they are the only extant echinoderms retaining the ancestral body plan of the group, crinoids are extremely valuable models to clarify neural evolution in deuterostomes. Read More

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December 2018
1 Read

Long-range projections from sparse populations of GABAergic neurons in murine subplate.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Department of Physiology, Anatomy and Genetics, Parks Road, Oxford.

The murine subplate contains some of the earliest generated populations of neurons in the cerebral cortex, which play an important role in the maturation of cortical inhibition. Here we present multiple lines of evidence, that the subplate itself is only very sparsely populated with GABAergic neurons at postnatal day (P)8. We used three different transgenic mouse lines, each of which labels a subset of GABAergic, ganglionic eminence derived neurons. Read More

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December 2018
9 Reads

Genetic profiling of basal cell carcinomas detects postzygotic mosaicism in basal cell naevus syndrome.

Br J Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands.

Basal cell naevus syndrome (BCNS) is associated with germline mutations in the PTCH1 gene. Postzygotic mosaicism can also cause BCNS. Here we describe two patients, one with multiple basal cell carcinomas (BCCs) and one with clinical BCNS, who had no PTCH1 mutation in DNA extracted from blood. Read More

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December 2018
1 Read

The effects of five types of tea solutions on epiboly process, neural and cardiovascular development, and locomotor capacity of zebrafish.

Cell Biol Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Department of Histology and Embryology, School of Medicine, Nankai University, Tianjin, 300071, China.

The effects of teas on embryonic development are still known little. The objective of this study was to compare and analyze developmental effects of green tea, delicate flavor oolong tea, strong flavor oolong tea, black tea, and pu'er tea using zebrafish embryos. Embryos were exposed in tea solutions from one-cell stage; the morphology, locomotor capacity, and gene expression of embryos or larvae were analyzed. Read More

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December 2018

Phenotypic Screening Using Mouse and Human Stem Cell-Based Models of Neuroinflammation and Gene Expression Analysis to Study Drug Responses.

Methods Mol Biol 2019 ;1888:21-43

Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.

High-throughput phenotypic screening enables the identification of new therapeutic targets even when the molecular mechanism underlying the disease is unknown. In the case of neurodegenerative disease, there is a dire need to identify new targets that can ameliorate, halt, or reverse degeneration. Stem cell-based disease models are particularly powerful tools for phenotypic screening because they use the same cell type affected in patients. Read More

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January 2019

Do emotional difficulties and peer problems occur together from childhood to adolescence? The case of children with a history of developmental language disorder (DLD).

Eur Child Adolesc Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

City, University of London, London, UK.

Children and adolescents with developmental language disorder (DLD) are, overall, vulnerable to difficulties in emotional adjustment and in peer relations. However, previous research has shown that different subgroups follow different trajectories in respect to the quality of peer relations. Less is known about the trajectories of emotional development. Read More

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December 2018
1 Read

Correlation analysis of the transcriptome and metabolome reveals the regulatory network for lipid synthesis in developing Brassica napus embryos.

Plant Mol Biol 2018 Dec 5. Epub 2018 Dec 5.

Animal Sciences National Teaching Demonstration Center, Nanjing Agricultural University, Nanjing, 210095, China.

Key Message: In this manuscript, we explored the key molecular networks for oil biosynthesis with the transcriptome and metabolome of B. napus embryo at different developmental stages. Brassica napus (B. Read More

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December 2018
1 Read

Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa.

Mol Neurobiol 2018 Dec 5. Epub 2018 Dec 5.

Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

In MRI scans of patients with anorexia nervosa (AN), reductions in brain volume are often apparent. However, it is unknown whether such brain abnormalities are influenced by genetic determinants that partially overlap with those underlying AN. Here, we used a battery of methods (LD score regression, genetic risk scores, sign test, SNP effect concordance analysis, and Mendelian randomization) to investigate the genetic covariation between subcortical brain volumes and risk for AN based on summary measures retrieved from genome-wide association studies of regional brain volumes (ENIGMA consortium, n = 13,170) and genetic risk for AN (PGC-ED consortium, n = 14,477). Read More

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December 2018
1 Read

Autism Spectrum Disorder: Incidence and Time Trends Over Two Decades in a Population-Based Birth Cohort.

J Autism Dev Disord 2018 Dec 5. Epub 2018 Dec 5.

Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

We retrospectively identified autism spectrum disorder (ASD) incident cases among 31,220 individuals in a population-based birth cohort based on signs and symptoms uniformly abstracted from medical and educational records. Inclusive and narrow research definitions of ASD (ASD-R and ASD-R, respectively) were explored, along with clinical diagnoses of ASD (ASD-C) obtained from the records. The incidence of ASD-R ASD-R, and ASD-C increased significantly from 1985 to 1998, then ASD-R and ASD-R plateaued while the rate of ASD-C continued to increase during 1998-2004. Read More

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December 2018
1 Read

Allogeneic stem cell transplantation with reduced intensity conditioning for patients with adrenoleukodystrophy.

Mol Genet Metab Rep 2019 Mar 20;18:1-6. Epub 2018 Nov 20.

Department of Hematology and Oncology, Children' Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.

Objective: The prognosis of adrenoleukodystrophy (ALD)with neurological involvement is generally dismal; however, allogeneic stem cell transplantation (SCT) is recognized as effective to stabilize or improve the clinical symptoms of ALD. Herein, we report the clinical outcomes of patients with ALD who consecutively underwent allogeneic stem cell transplantation with reduced intensity conditioning at our institution.

Patients: Sixteen patients with ALD, who were symptomatic (n = 14) or presymptomatic (n = 2), received SCT from 2010 to 2016. Read More

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March 2019
1 Read

Effects of waste stream combinations from brewing industry on performance of Black Soldier Fly, (Diptera: Stratiomyidae).

PeerJ 2018 28;6:e5885. Epub 2018 Nov 28.

Plant Health Theme, International Centre of Insect Physiology and Ecology (icipe), Nairobi, Kenya.

Background: In recent years, there has been a rapidly growing demand for readily accessible substrates for mass production of Black Soldier Fly, Linnaeus. Beer production results in various by-products that typically end up in uncontrolled dumpsites constituting pollution problems, which merits urgent attention. The present study investigated whether the 12 formulated diets composed of brewers' spent grains (BSGs), brewers' yeast and cane molasses can serve as substrate for production. Read More

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November 2018

Embryonal life histories: Desiccation plasticity and diapause in the Argentinean pearlfish .

Ecol Evol 2018 Nov 30;8(22):11246-11260. Epub 2018 Oct 30.

Centre for Biodiversity Naturalis Leiden The Netherlands.

Embryos of annual killifish diapause in soil egg banks while ponds are dry. Their rates of development and survival in different developmental stages determine the numbers and stages of embryos at rewetting. In the Argentinean pearlfish , we investigated plasticity for desiccation in such embryonal life history components across phases of mild desiccation and rewetting and also effects of life history on hatching. Read More

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November 2018

Transcriptomic responses to predator kairomones in embryos of the aquatic snail .

Ecol Evol 2018 Nov 17;8(22):11071-11082. Epub 2018 Oct 17.

Marine Biology and Ecology Research Centre University of Plymouth, Drake Circus Plymouth UK.

The ability of organisms to respond to predation threat by exhibiting induced defenses is well documented, but studies on the potential mechanistic basis for such responses are scarce. Here, we examine the transcriptomic response to predator kairomones of two functionally distinct developmental stages in embryos of the aquatic snail : E8-the stage at which a range-finding trial indicated that kairomone-induced accelerated growth and development first occurred; and E9-the stage at which embryos switched from ciliary- to crawling-driven locomotion. We tested whether expression profiles were influenced by kairomones and whether this influence varied between stages. Read More

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November 2018
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Efficacy of CapeOX plus Cetuximab Treatment as a First-Line Therapy for Patients with Extended RAS/BRAF/PIK3CA Wild-Type Advanced or Metastatic Colorectal Cancer.

J Cancer 2018 18;9(22):4092-4098. Epub 2018 Oct 18.

Kitakyushu General Hospital, Kitakyushu, Japan.

Oxaliplatin and capecitabine (CapeOX) combined with cetuximab is rarely used to treat advanced and metastatic colorectal cancer (mCRC). The present study aimed to clarify the clinical benefits of this treatment regimen when used as a first-line therapy in patients with expanded RAS/BRAF/PIK3CA wild-type mCRC, using the data and tumor specimens from two previously published Phase II clinical trials. The gene mutation status and clinical data of 102 patients with KRAS wild-type mCRC, who received either of CapeOX + cetuximab or FOLFOX + cetuximab, were analyzed. Read More

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October 2018

Identification of QTNs Controlling Seed Protein Content in Soybean Using Multi-Locus Genome-Wide Association Studies.

Front Plant Sci 2018 21;9:1690. Epub 2018 Nov 21.

Key Laboratory of Soybean Biology in the Chinese Ministry of Education, Northeast Agricultural University, Harbin, China.

Protein content (PC), an important trait in soybean () breeding, is controlled by multiple genes with relatively small effects. To identify the quantitative trait nucleotides (QTNs) controlling PC, we conducted a multi-locus genome-wide association study (GWAS) for PC in 144 four-way recombinant inbred lines (FW-RILs). All the FW-RILs were phenotyped for PC in 20 environments, including four locations over 4 years with different experimental treatments. Read More

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November 2018

Host Adaptive Immune Status Regulates Expression of the Schistosome AMP-Activated Protein Kinase.

Front Immunol 2018 21;9:2699. Epub 2018 Nov 21.

Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Schistosomes exhibit profound developmental adaptations in response to the immune status of their mammalian host, including significant attenuation of parasite growth, development and reproduction in response to deficits in host adaptive immunity. These observations led us to hypothesize that schistosomes regulate the utilization of energy resources in response to immunological conditions within the host. To test this hypothesis, we identified and characterized the AMP-activated protein kinase (AMPK), a heterotrimeric enzyme complex that is central to regulating energy metabolism at the cellular and organismal level in eukaryotes. Read More

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November 2018