18,419 results match your criteria Developmental Biology[Journal]


Eph/ephrin signalling in the development and function of the mammalian cochlea.

Authors:
Jean Defourny

Dev Biol 2019 Feb 13. Epub 2019 Feb 13.

GIGA-Neurosciences, Unit of Cell and Tissue Biology, University of Liège, C.H.U. B36, B-4000, Liège, Belgium. Electronic address:

In mammals, the functional development of the cochlea requires the tight regulation of multiple molecules and signalling pathways including fibroblast growth factors, bone morphogenetic proteins, Wnt and Notch signalling pathways. Over the last decade, the Eph/ephrin system also emerged as a key player of the development and function of the mammalian cochlea. In this review, we discuss the recent advances on the role of Eph/ephrin signalling in patterning the cochlear sensory epithelium and the complex innervation of mechanosensory hair cells by spiral ganglion neurons. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.004DOI Listing
February 2019

miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta.

Dev Biol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, Box 60, New York, NY 10065. Electronic address:

A functional placenta develops through a delicate interplay of its vascular and trophoblast compartments. We have identified a previously unknown expression domain for the endothelial-specific microRNA miR-126 in trophoblasts of murine and human placentas. Here, we determine the role of miR-126 in placental development using a mouse model with a targeted deletion of miR-126. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.019DOI Listing
February 2019

Transcriptional and post-transcriptional regulation of extra macrochaetae during Drosophila adult peripheral neurogenesis.

Dev Biol 2019 Feb 13. Epub 2019 Feb 13.

Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx NY 10461, USA; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx NY 10461, USA; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx NY 10461, USA. Electronic address:

Regulation of the Drosophila ID protein Extra macrochaetae (Emc) is important because reduced Emc levels have been proposed to favor proneural gene activity and thereby define a prepattern for neurogenesis. Recent studies suggest a major role for post-translational control of Emc levels. To further define the mechanisms of Emc regulation, we identified two redundant cis-regulatory regions by germline transformation-rescue experiments that make use of new molecularly-defined emc mutants. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.003DOI Listing
February 2019

Pancreatic pericytes originate from the embryonic pancreatic mesenchyme.

Dev Biol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

The embryonic origin of pericytes is heterogeneous, both between and within organs. While pericytes of coelomic organs were proposed to differentiate from the mesothelium, a single-layer squamous epithelium, the embryonic origin of pancreatic pericytes has yet to be reported. Here, we show that adult pancreatic pericytes originate from the embryonic pancreatic mesenchyme. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.020DOI Listing
February 2019

The biology of the extracorporeal vasculature of Botryllus schlosseri.

Dev Biol 2018 Oct 25. Epub 2018 Oct 25.

Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA.

The extracorporeal vasculature of the colonial ascidian Botryllus schlosseri plays a key role in several biological processes: transporting blood, angiogenesis, regeneration, self-nonself recognition, and parabiosis. The vasculature also interconnects all individuals in a colony and is composed of a single layer of ectodermally-derived cells. These cells form a tube with the basal lamina facing the lumen, and the apical side facing an extracellular matrix that consists of cellulose and other proteins, known as the tunic. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.10.013DOI Listing
October 2018

Adaptation of blind cavefish to nutrient poor environments: uncovering diverse new mechanisms that regulate body fat levels.

Dev Biol 2019 Feb 7. Epub 2019 Feb 7.

Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, Scotland EH16 4TJ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.01.017DOI Listing
February 2019

The regulation of cell size and branch complexity in the terminal cells of the Drosophila tracheal system.

Dev Biol 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology and Cell Biology, Columbia University Medical Center, 630 168th St, New York, NY 10032, USA. Electronic address:

The terminal cells of the larval Drosophila tracheal system extend dozens of branched cellular processes, most of which become hollow intracellular tubes that support gas exchange with internal tissues. Previously, we undertook a forward genetic mosaic screen to uncover the pathways regulating terminal cell size, morphogenesis, and the generation and maintenance of new intracellular tubes. Our initial work identified several mutations affecting terminal cell size and branch number, and suggested that branch complexity and cell size are typically coupled but could be genetically separated. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.001DOI Listing
February 2019

Prickle1 is required for EMT and migration of zebrafish cranial neural crest.

Dev Biol 2019 Feb 2. Epub 2019 Feb 2.

Committee on Development, Regeneration and Stem Cell Biology, The University of Chicago; Department of Organismal Biology and Anatomy, The University of Chicago.

The neural crest-a key innovation of the vertebrates-gives rise to diverse cell types including melanocytes, neurons and glia of the peripheral nervous system, and chondrocytes of the jaw and skull. Proper development of the cephalic region is dependent on the tightly-regulated specification and migration of cranial neural crest cells (NCCs). The core PCP proteins Frizzled and Disheveled have previously been implicated in NCC migration. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.018DOI Listing
February 2019

Vitelline membrane proteins promote left-sided nodal expression after neurula rotation in the ascidian, Halocynthia roretzi.

Dev Biol 2019 Jan 30. Epub 2019 Jan 30.

Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan. Electronic address:

Stereotyped left-right asymmetry both in external and internal organization is found in various animals. Left-right symmetry is broken by the neurula rotation in the ascidian, Halocynthia roretzi. Neurula embryos rotate along the anterior-posterior axis in a counterclockwise direction, and the rotation stops when the left side of the embryo is oriented downwards, resulting in contact of the left-side epidermis with the vitelline membrane at the bottom of perivitelline space. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.016DOI Listing
January 2019

Interleukin-6 increases inner cell mass numbers in bovine embryos.

BMC Dev Biol 2019 Feb 1;19(1). Epub 2019 Feb 1.

Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, 3430 Litton-Reaves Hall (0306), Blacksburg, VA, 24060, USA.

Background: Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate the role of IL6 during in vitro bovine embryo production. Read More

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http://dx.doi.org/10.1186/s12861-019-0182-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359871PMC
February 2019

Loss of the neurodevelopmental Joubert syndrome causing protein, Ahi1, causes motor and muscle development delays independent of central nervous system involvement.

Dev Biol 2019 Jan 26. Epub 2019 Jan 26.

Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York 12208, USA; Department of Neurology, Albany Medical College, Albany, New York 12208, USA. Electronic address:

Joubert syndrome (JBTS) is a predominantly autosomal recessive neurodevelopmental disorder that presents with characteristic malformations of the cerebellar vermis, superior cerebellar peduncles and midbrain in humans. Accompanying these malformations are a heterogeneous set of clinical symptoms, which frequently include deficits in motor and muscle function, such as hypotonia (low muscle tone) and ataxia (clumsiness). These symptoms are attributed to improper development of the hindbrain, but no direct evidence has been reported linking these in JBTS. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.014DOI Listing
January 2019

Dynamic expression of Drosophila segmental cell surface-encoding genes and their pair-rule regulators.

Dev Biol 2019 Jan 26. Epub 2019 Jan 26.

Entomology Department, University of Maryland, College Park, MD 20742, United States. Electronic address:

Drosophila segmentation is regulated by a complex network of transcription factors that include products of the pair-rule genes (PRGs). PRGs are expressed in early embryos in the primorida of alternate segmental units, establishing the repeated, segmental body plan of the fly. Despite detailed analysis of the regulatory logic among segmentation genes, the relationship between these genes and the morphological formation of segments is still poorly understood, since regulation of transcription factor expression is not sufficient to explain how segments actually form and are maintained. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183069
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http://dx.doi.org/10.1016/j.ydbio.2019.01.015DOI Listing
January 2019
3 Reads

Ablating the fixed lineage conjecture: Commentary on Kimble 1981.

Authors:
Paul W Sternberg

Dev Biol 2019 Feb;446(1):1-16

BBE, Caltech, United States.

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http://dx.doi.org/10.1016/j.ydbio.2018.12.024DOI Listing
February 2019

Drosophila ML-DmD17-c3 cells respond robustly to Dpp and exhibit complex transcriptional feedback on BMP signaling components.

BMC Dev Biol 2019 Jan 22;19(1). Epub 2019 Jan 22.

Center for Vision Research and Department of Ophthalmology, Upstate Medical University, NRB-4610, 505 Irving Ave, Syracuse, 13210, NY, USA.

Background: BMP signaling is involved in myriad metazoan developmental processes, and study of this pathway in Drosophila has contributed greatly to our understanding of its molecular and genetic mechanisms. These studies have benefited not only from Drosophila's advanced genetic tools, but from complimentary in vitro culture systems. However, the commonly-used S2 cell line is not intrinsically sensitive to the major BMP ligand Dpp and must therefore be augmented with exogenous pathway components for most experiments. Read More

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http://dx.doi.org/10.1186/s12861-019-0181-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341649PMC
January 2019

"Be Healthy as a Fish" educational program - Presenting how zebrafish can improve our understanding of human diseases.

Authors:
Daria Goś

Dev Biol 2019 Jan 19. Epub 2019 Jan 19.

International Institute of Molecular and Cell Biology in Warsaw, 4 Ks. Trojdena Street, 02-109 Warsaw, Poland. Electronic address:

While mice and rats are still the most common choices for modeling human diseases, the use of zebrafish (Danio rerio) is becoming increasingly popular. In response to this growing potential, the International Institute of Molecular and Cell Biology in Warsaw (IIMCB) decided to introduce the Be Healthy as a Fish campaign in 2014. The program aims to educate school children on how the zebrafish can be used as a model organism to help scientists understand the way the human body works. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.012DOI Listing
January 2019

Maintaining multipotent trunk neural crest stem cells as self-renewing crestospheres.

Dev Biol 2019 Jan 18. Epub 2019 Jan 18.

Neural Crest Development and Disease Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA; Department of Biochemistry and Developmental Biology, Medicum, University of Helsinki, Helsinki, Finland. Electronic address:

Neural crest cells have broad migratory and differentiative ability that differs according to their axial level of origin. However, their transient nature has limited understanding of their stem cell and self-renewal properties. While an in vitro culture method has made it possible to maintain cranial neural crest cells as self-renewing multipotent crestospheres (Kerosuo et al. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.010DOI Listing
January 2019
4 Reads

Positioning a multifunctional basic helix-loop-helix transcription factor within the Ciona notochord gene regulatory network.

Dev Biol 2019 Jan 17. Epub 2019 Jan 17.

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, 345 E 24th Street, New York, NY 10010, USA. Electronic address:

In a multitude of organisms, transcription factors of the basic helix-loop-helix (bHLH) family control the expression of genes required for organ development and tissue differentiation. The functions of different bHLH transcription factors in the specification of nervous system and paraxial mesoderm have been widely investigated in various model systems. Conversely, the knowledge of the role of these regulators in the development of the axial mesoderm, the embryonic territory that gives rise to the notochord, and the identities of their target genes, remain still fragmentary. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183051
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http://dx.doi.org/10.1016/j.ydbio.2019.01.002DOI Listing
January 2019
5 Reads

Evolution of embryonic cis-regulatory landscapes between divergent Phallusia and Ciona ascidians.

Dev Biol 2019 Jan 17. Epub 2019 Jan 17.

Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), Université de Montpellier, CNRS, Montpellier, France. Electronic address:

Ascidian species of the Phallusia and Ciona genera are distantly related, their last common ancestor dating several hundred million years ago. Although their genome sequences have extensively diverged since this radiation, Phallusia and Ciona species share almost identical early morphogenesis and stereotyped cell lineages. Here, we explored the evolution of transcriptional control between P. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.003DOI Listing
January 2019
1 Read

Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds.

Dev Biol 2019 Jan 16. Epub 2019 Jan 16.

Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address:

DNA methyltransferase 1 (DNMT1) is required for embryogenesis but roles in late forming organ systems including the prostate, which emerges from the urethral epithelium, have not been fully examined. We used a targeted genetic approach involving a Shhcre recombinase to demonstrate requirement of epithelial DNA methyltransferase-1 (Dnmt1) in mouse prostate morphogenesis. Dnmt1 mutant urethral cells exhibit DNA hypomethylation, DNA damage, p53 accumulation and undergo cell cycle arrest and apoptosis. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.011DOI Listing
January 2019
1 Read

Zebrafish embryogenesis - A framework to study regulatory RNA elements in development and disease.

Dev Biol 2019 Jan 16. Epub 2019 Jan 16.

Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom. Electronic address:

Post-transcriptional gene regulation through the recognition of specific elements in mRNAs is an important determinant of gene expression. The cis elements are recognised by RNA binding proteins (RBPs) and/or small non-coding RNAs, which then orchestrate a range of processes such as mRNA localization, translational control, and degradation. RNA regulation is critical for development and disruptions in regulatory mechanisms can cause disease. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.008DOI Listing
January 2019
1 Read

Commentary on Le Douarin, 1973 and 1974.

Authors:
Marianne Bronner

Dev Biol 2019 Jan;445(2):115-144

California Institute of Technology, Pasadena, California, USA.

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http://dx.doi.org/10.1016/j.ydbio.2018.12.011DOI Listing
January 2019
1 Read

Insemination or phosphatidic acid induces an outwardly spiraling disk of elevated Ca to produce the Ca wave during Xenopus laevis fertilization.

Dev Biol 2019 Jan 11. Epub 2019 Jan 11.

University of Colorado Denver, CO, USA. Electronic address:

During Xenopus fertilization, the initial intracellular calcium ((Ca)) release at the sperm-egg binding site (hot spot) has not been described without the use of inhibitors, nor related to underlying ER structure. Without inhibitors, we now report that sperm induce an initial hot spot after sperm addition to Xenopus eggs that was ~25 µm. This area is consistent with the size of ER patches and clusters of IP3 receptors that have enhanced activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183059
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http://dx.doi.org/10.1016/j.ydbio.2019.01.004DOI Listing
January 2019
3 Reads

Electroporation of short hairpin RNAs for rapid and efficient gene knockdown in the starlet sea anemone, Nematostella vectensis.

Dev Biol 2019 Jan 11. Epub 2019 Jan 11.

Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA; Dept. Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160 USA. Electronic address:

A mechanistic understanding of evolutionary developmental biology requires the development of novel techniques for the manipulation of gene function in phylogenetically diverse organismal systems. Recently, gene-specific knockdown by microinjection of short hairpin RNA (shRNA) was applied in the sea anemone Nematostella vectensis, demonstrating that the shRNA approach can be used for efficient and robust sequence-specific knockdown of a gene of interest. However, the time- and labor-intensive process of microinjection limits access to this technique and its application in large scale experiments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183063
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http://dx.doi.org/10.1016/j.ydbio.2019.01.005DOI Listing
January 2019
4 Reads

WITHDRAWN: Editorial Introduction.

Dev Biol 2019 Jan 11. Epub 2019 Jan 11.

Karolinska Institutet, Sweden.

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http://dx.doi.org/10.1016/j.ydbio.2019.01.009DOI Listing
January 2019
1 Read

Initial characterization of Wnt-Tcf functions during Ciona heart development.

Dev Biol 2019 Jan 8. Epub 2019 Jan 8.

Center for Developmental Genetics, Department of Biology, New York University, New York, NY, USA. Electronic address:

In vertebrate embryos, the cardiopharyngeal mesoderm gives rise to both cardiac and branchiomeric head muscles. The canonical Wnt signaling pathway regulates many aspects of cardiomyocyte specification, and modulates a balance between skeletal and cardiac myogenesis during vertebrate head muscle development. However, the role of Wnt signaling during ascidian cardiopharyngeal development remains elusive. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.018DOI Listing
January 2019
1 Read

The cadherin-catenin complex is necessary for cell adhesion and embryogenesis in Nematostella vectensis.

Dev Biol 2019 Jan 7. Epub 2019 Jan 7.

Department of Biology, Stanford University, Stanford CA 94305, United States; Department of Molecular and Cellular Physiology, Stanford University, Stanford CA 94305, United States. Electronic address:

The cadherin-catenin complex is a conserved, calcium-dependent cell-cell adhesion module that is necessary for normal development and the maintenance of tissue integrity in bilaterian animals. Despite longstanding evidence of a deep ancestry of calcium-dependent cell adhesion in animals, the requirement of the cadherin-catenin complex to coordinate cell-cell adhesion has not been tested directly in a non-bilaterian organism. Here, we provide the first analysis of classical cadherins and catenins in the Starlet Sea Anemone, Nematostella vectensis. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.007DOI Listing
January 2019
1 Read

Quantitative analysis reveals genotype- and domain- specific differences between mRNA and protein expression of segmentation genes in Drosophila.

Dev Biol 2019 Jan 7. Epub 2019 Jan 7.

Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya, 29, St. Petersburg 195251, Russia. Electronic address:

In many biological systems gene expression at mRNA and protein levels is not identical. Rigorous comparison of such differences on a spatio-temporal scale is still not feasible by high-throughput transcriptomic and proteomic analyses of early embryo development. Here, we characterize differences between mRNA and protein expression of Drosophila segmentation genes at the level of individual gene expression domains. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183012
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http://dx.doi.org/10.1016/j.ydbio.2019.01.006DOI Listing
January 2019
6 Reads

The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling.

Dev Biol 2019 Feb 3;446(2):142-150. Epub 2019 Jan 3.

Model Animal Research Centre, Nanjing University, China. Electronic address:

Ventricular trabeculation is one essential step for generating a functionally competent ventricular wall, while how the early trabeculae carneae forms and subsequently develops into mature chambers is poorly understood. We found that in zebrafish zfpm1 juvenile, cardiac function is significantly compromised, with hearts exhibiting deformed trabecular meshwork. To elucidate the mechanisms of Zfpm1 function in cardiac trabeculation, we analyzed zfpm1 mutant hearts more closely and found that loss of Zfpm1 activity resulted in over-activation of Neuregulin-ErbB signalling and abnormally elevated cardiomyocyte proliferation during cardiac trabeculae growth and modeling stages. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.01.001DOI Listing
February 2019
2 Reads

Atoh1 and other related key regulators in the development of auditory sensory epithelium in the mammalian inner ear: function and interplay.

Dev Biol 2019 Feb 31;446(2):133-141. Epub 2018 Dec 31.

Institute of Cell and Developmental Biology, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address:

Damage or loss of auditory hair cells leads to irreversible sensorineural hearing loss in human, thus regeneration of these cells to reconstruct auditory sensory epithelium holds the promise for the treatment of deafness. Regulatory factors involved in the development of auditory sensory epithelium play crucial roles in hair cell regeneration and hearing restoration. Here, we first focus on the transcription factor Atoh1 which is critical for hair cell development and regeneration, and comprehensively summarize the current understanding of the protein structure, target binding motif, developmental expression pattern, functional role, and upstream and downstream regulatory mechanism of Atoh1 in the context of controlling the cell fate commitment to hair cells or transdifferentiation from supporting cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183072
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http://dx.doi.org/10.1016/j.ydbio.2018.12.025DOI Listing
February 2019
7 Reads

Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex.

Dev Biol 2019 Feb 30;446(2):193-205. Epub 2018 Dec 30.

Department of Biology, University of Maryland, College Park, MD, USA. Electronic address:

Proper germ cell sex determination in Caenorhabditis nematodes requires a network of RNA-binding proteins (RBPs) and their target mRNAs. In some species, changes in this network enabled limited XX spermatogenesis, and thus self-fertility. In C. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.11.024DOI Listing
February 2019
1 Read

The tail of the underwater phoenix.

Authors:
Baruch Rinkevich

Dev Biol 2018 Dec 27. Epub 2018 Dec 27.

Israel Oceanographic&Limnological Research, National Institute of Oceanography, Tel Shikmona, PO Box 8030, Haifa 31080, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2018.12.015DOI Listing
December 2018
1 Read

Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination.

Dev Biol 2019 Feb 27;446(2):168-179. Epub 2018 Dec 27.

Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, United States.

Cis-regulatory elements are critical for the precise spatiotemporal regulation of genes during development. However, identifying functional regulatory sites that drive cell differentiation in vivo has been complicated by the high numbers of cells required for whole-genome epigenetic assays. Here, we identified putative regulatory elements during sex determination by performing ATAC-seq and ChIP-seq for H3K27ac in purified XX and XY gonadal supporting cells before and after sex determination in mice. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368449PMC
February 2019
1 Read

An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages.

Dev Biol 2019 Feb 27;446(2):180-192. Epub 2018 Dec 27.

Department of Cell and Developmental Biology, University of Illinois, Urbana-Champaign, United States. Electronic address:

The evolutionarily conserved transcription factor, Tbx18, is expressed in a dynamic pattern throughout embryonic and early postnatal life and plays crucial roles in the development of multiple organ systems. Previous studies have indicated that this dynamic function is controlled by an expansive regulatory structure, extending far upstream and downstream of the gene. With the goal of identifying elements that interact with the Tbx18 promoter in developing prostate, we coupled chromatin conformation capture (4C) and ATAC-seq from embryonic day 18. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368454PMC
February 2019
1 Read

Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence.

Dev Biol 2018 Dec 25. Epub 2018 Dec 25.

Institut für Genetik, TU Braunschweig, Braunschweig, Germany.

The four Caenorhabditis species C. elegans, C. briggsae, C. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.022DOI Listing
December 2018
1 Read

Transcriptional regulation of the Ciona Gsx gene in the neural plate.

Dev Biol 2018 Dec 21. Epub 2018 Dec 21.

Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Napoli 80121, Italy.

The ascidian neural plate consists of a defined number of identifiable cells organized in a grid of rows and columns, representing a useful model to investigate the molecular mechanisms controlling neural patterning in chordates. Distinct anterior brain lineages are specified via unique combinatorial inputs of signalling pathways with Nodal and Delta-Notch signals patterning along the medial-lateral axis and FGF/MEK/ERK signals patterning along the anterior-posterior axis of the neural plate. The Ciona Gsx gene is specifically expressed in the a9. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183038
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http://dx.doi.org/10.1016/j.ydbio.2018.12.013DOI Listing
December 2018
5 Reads

Draxin alters laminin organization during basement membrane remodeling to control cranial neural crest EMT.

Dev Biol 2019 Feb 21;446(2):151-158. Epub 2018 Dec 21.

Department of Biology and Biological Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125, USA. Electronic address:

Premigratory neural crest cells arise within the dorsal neural tube and subsequently undergo an epithelial-to-mesenchymal transition (EMT) to leave the neuroepithelium and initiate migration. Draxin is a Wnt modulator that has been shown to control the timing of cranial neural crest EMT. Here we show that this process is accompanied by three stages of remodeling of the basement membrane protein laminin, from regression to expansion and channel formation. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368465PMC
February 2019
1 Read

PCP-dependent transcellular regulation of actomyosin oscillation facilitates convergent extension of vertebrate tissue.

Dev Biol 2019 Feb 21;446(2):159-167. Epub 2018 Dec 21.

Department of Molecular Biosciences, University of Texas at Austin, 78712, USA.

Oscillatory flows of actomyosin play a key role in the migration of single cells in culture and in collective cell movements in Drosophila embryos. In vertebrate embryos undergoing convergent extension (CE), the Planar Cell Polarity (PCP) pathway drives the elongation of the body axis and shapes the central nervous system, and mutations of the PCP genes predispose humans to various malformations including neural tube defects. However, the spatiotemporal patterns of oscillatory actomyosin contractions during vertebrate CE and how they are controlled by the PCP signaling remain unknown. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.017DOI Listing
February 2019
2 Reads

Functional conserved non-coding elements among tunicates and chordates.

Dev Biol 2018 Dec 19. Epub 2018 Dec 19.

Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy. Electronic address:

Non-coding regions with dozens to several hundred base pairs of extreme conservation have been found in all metazoan genomes. The distribution of these conserved non-coding elements (CNE) within and across genomes has suggested that many of them may have roles as transcriptional regulatory elements. A combination of bioinformatics and experimental approaches can be used to identify CNEs with regulatory activity in phylogenetically distant species. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.012DOI Listing
December 2018
1 Read

Leukemia inhibitory factor signaling in Xenopus embryo: Insights from gain of function analysis and dominant negative mutant of the receptor.

Dev Biol 2018 Dec 19. Epub 2018 Dec 19.

Univ. Bordeaux, INSERM U1035, BMGIC, F-33076 Bordeaux, France. Electronic address:

Leukemia inhibitory factor (LIF) is a cytokine member of the interleukin 6 family (IL6) of cytokines. It signals through a heterodimer receptor complex that consists of the LIF receptor (or LIFR formerly known as gp190) and the Interleukin 6 signal transducer (or IL6ST formerly known as gp130). LIF signaling is mediated mainly by signal transducer and activator of transcription 3 (STAT3) and has a wide variety of biological activities with pleiotropic effects on many cell types and organs among which are stem cell renewal and implantation process in mammalian embryo. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.020DOI Listing
December 2018
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Method for disarranging the pigment pattern of zebrafish by optogenetics.

Dev Biol 2018 Dec 19. Epub 2018 Dec 19.

Graduate School of Frontier Biosciences, Osaka University, Japan. Electronic address:

To investigate the spatiotemporal dynamics of skin pattern formation, we developed a simple method for artificially disarranging the placement of all three pigment cell types in the body trunk of zebrafish (Danio rerio). We generated transgenic fish with melanophores that ectopically expressed a variant of channelrhodopsin-2 (ChR2). Blue light (BL) irradiation induced melanophore depolarization and random migration; the latter resulted in the disarrangement of the two other pigment cell types (xanthophores and iridophores). Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.019DOI Listing
December 2018
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Environmental cycles regulate development time via circadian clock mediated gating of adult emergence.

BMC Dev Biol 2018 Dec 22;18(1):21. Epub 2018 Dec 22.

Behavioural Neurogenetics Laboratory, Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India.

Background: Previous studies have implicated a role for circadian clocks in regulating pre-adult development of organisms. Among them two approaches are most notable: 1) use of insects whose clocks have different free-running periods and 2) imposition of artificial selection on either rate of development, timing of emergence or circadian period in laboratory populations. Using these two approaches, influence of clock on rate of development has been elucidated. Read More

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http://dx.doi.org/10.1186/s12861-018-0180-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303858PMC
December 2018
1 Read

Glycerophospholipids - Emerging players in neuronal dendrite branching and outgrowth.

Dev Biol 2018 Dec 18. Epub 2018 Dec 18.

German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud Straße 27, 53127 Bonn, Germany; LIMES Institute, University of Bonn, Carl-Troll Straße 31, 53115 Bonn, Germany.

Dendrites are the input compartment of the neuron, receiving and integrating incoming information. Dendritic trees are often highly complex and branched. Their branch extension and distribution are tightly correlated with their role and interactions within neuronal networks. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.009DOI Listing
December 2018
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Cellular and molecular determinants of normal and abnormal kidney development.

Wiley Interdiscip Rev Dev Biol 2019 Mar 20;8(2):e338. Epub 2018 Dec 20.

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.

Kidneys are bilateral organs required to maintain homeostasis in the body through the regulation of fluid composition and the excretion of metabolic waste products. The initial steps in organ development are characterized by cellular interactions which regulate both the position and number of kidneys formed. Once established, further development is driven by orchestrated interactions between progenitor cell populations which serve to establish both nephrons-the functional unit of the organ which filters the blood-and the complex ramified collecting duct system which transports urine to the bladder. Read More

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http://dx.doi.org/10.1002/wdev.338DOI Listing
March 2019
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De novo neurogenesis in a budding chordate: Co-option of larval anteroposterior patterning genes in a transitory neurogenic organ.

Dev Biol 2018 Oct 25. Epub 2018 Oct 25.

Sorbonne Universités, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-mer (LBDV), 06230 Paris, France. Electronic address:

During metamorphosis of solitary ascidians, part of the larval tubular nervous system is recruited to form the adult central nervous system (CNS) through neural stem-like cells called ependymal cells. The anteroposterior (AP) gene expression patterning of the larval CNS regionalize the distribution of the ependymal cells, which contains the positional information of the neurons of the adult nervous system. In colonial ascidians, the CNS of asexually developed zooids has the same morphology of the one of the post-metamorphic zooids. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606173088
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http://dx.doi.org/10.1016/j.ydbio.2018.10.009DOI Listing
October 2018
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Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.

Dev Biol 2019 Feb 15;446(1):119-131. Epub 2018 Dec 15.

Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

Epithelial cell polarity, adhesion, proliferation, differentiation and survival are essential for morphogenesis of various organs and tissues including the ocular lens. The molecular mechanisms regulating the lens epithelial phenotype however, are not well understood. Here we investigated the role of scaffolding protein ankyrin-G (AnkG) in mouse lens development by conditional suppression of AnkG expression using the Cre-LoxP recombination approach. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.016DOI Listing
February 2019
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Generating and working with Drosophila cell cultures: Current challenges and opportunities.

Wiley Interdiscip Rev Dev Biol 2018 Dec 18:e339. Epub 2018 Dec 18.

Department of Biology, Drosophila Genomics Resource Center, Indiana University Bloomington, Bloomington, Indiana.

The use of Drosophila cell cultures has positively impacted both fundamental and biomedical research. The most widely used cell lines: Schneider, Kc, the CNS and imaginal disc lines continue to be the choice for many applications. Drosophila cell lines provide a homogenous source of cells suitable for biochemical experimentations, transcriptomics, functional genomics, and biomedical applications. Read More

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http://dx.doi.org/10.1002/wdev.339DOI Listing
December 2018
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Live imaging reveals hub cell assembly and compaction dynamics during morphogenesis of the Drosophila testis niche.

Dev Biol 2019 Feb 13;446(1):102-118. Epub 2018 Dec 13.

The Perelman School of Medicine at the University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, United States; The Penn Institute for Regenerative Medicine, 421 Curie Blvd, Philadelphia, PA 19104, United States. Electronic address:

Adult stem cells are often found in specialized niches, where the constituent cells direct self-renewal of their stem cell pool. The niche is therefore crucial for both normal homeostasis and tissue regeneration. In many mammalian tissues, niche cells have classically been difficult to identify, which has hampered any understanding of how tissues first construct niches during development. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.014DOI Listing
February 2019
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FGFR1 regulates trophectoderm development and facilitates blastocyst implantation.

Dev Biol 2019 Feb 12;446(1):94-101. Epub 2018 Dec 12.

Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

FGF signaling plays important roles in many aspects of mammalian development. Fgfr1 and Fgfr1Fgfr2 mouse embryos on a 129S4 co-isogenic background fail to survive past the peri-implantation stage, whereas Fgfr2 embryos die at midgestation and show defects in limb and placental development. To investigate the basis for the Fgfr1 and Fgfr1Fgfr2 peri-implantation lethality, we examined the role of FGFR1 and FGFR2 in trophectoderm (TE) development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183077
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http://dx.doi.org/10.1016/j.ydbio.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370302PMC
February 2019
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Branching mechanisms shaping dendrite architecture.

Dev Biol 2018 Dec 12. Epub 2018 Dec 12.

The University of Queensland, Queensland Brain Institute, Brisbane, Queensland 4072, Australia. Electronic address:

A neuron's contribution to the information flow within a neural circuit is governed by the structure of its dendritic arbor. The geometry of the dendritic arbor directly determines synaptic density and the size of the receptive field, both of which influence the firing pattern of the neuron. Importantly, the position of individual dendritic branches determines the identity of the neuron's presynaptic partner and thus the nature of the incoming sensory information. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183033
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http://dx.doi.org/10.1016/j.ydbio.2018.12.005DOI Listing
December 2018
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Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila.

Dev Biol 2019 01 25;445(1):37-53. Epub 2018 Oct 25.

Department of Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, Irvine, CA 92697-2300, USA. Electronic address:

Analysis of mutants that affect formation and function of the Drosophila larval neuromuscular junction (NMJ) has provided valuable insight into genes required for neuronal branching and synaptic growth. We report that NMJ development in Drosophila requires both the Drosophila ortholog of FNDC3 genes; CG42389 (herein referred to as miles to go; mtgo), and CCT3, which encodes a chaperonin complex subunit. Loss of mtgo function causes late pupal lethality with most animals unable to escape the pupal case, while rare escapers exhibit an ataxic gait and reduced lifespan. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294335PMC
January 2019
2 Reads