18,470 results match your criteria Developmental Biology[Journal]


Automated in vivo screen in zebrafish identifies clotrimazole as targeting a metabolic vulnerability in a melanoma model.

Dev Biol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Experimental Cancer Biology, CIBIO Department, University of Trento, Via Sommarive 9, 38123 Povo TN, Italy. Electronic address:

Therapeutic approaches for cutaneous melanoma are flourishing, but despite promising results, there is an increasing number of reported primary or secondary resistance to the growing sets of drugs approved for therapy in the clinics. Combinatorial approaches may overcome resistance, as they may tackle specific weaknesses of melanoma cells, not sufficient on their own, but effective in combination with other therapies. The transgenic zebrafish line kita:ras develops melanoma with high frequency. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.04.005DOI Listing

Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis.

BMC Dev Biol 2019 Apr 17;19(1). Epub 2019 Apr 17.

MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

Background: The interstitium of the mouse testis contains Leydig cells and a small number of steroidogenic cells with adrenal characteristics which may be derived from the fetal adrenal during development or may be a normal subset of the developing fetal Leydig cells. Currently it is not known what regulates development and/or proliferation of this sub-population of steroidogenic cells in the mouse testis. Androgen receptors (AR) are essential for normal testicular function and in this study we have examined the role of the AR in regulating interstitial cell development. Read More

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http://dx.doi.org/10.1186/s12861-019-0189-5DOI Listing

Methods for the study of innate immunity in Drosophila melanogaster.

Wiley Interdiscip Rev Dev Biol 2019 Apr 16:e344. Epub 2019 Apr 16.

Department of Entomology, Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, New York.

From flies to humans, many components of the innate immune system have been conserved during metazoan evolution. This foundational observation has allowed us to develop Drosophila melanogaster, the fruit fly, into a powerful model to study innate immunity in animals. Thanks to an ever-growing arsenal of genetic tools, an easily manipulated genome, and its winning disposition, Drosophila is now employed to study not only basic molecular mechanisms of pathogen recognition and immune signaling, but also the nature of physiological responses activated in the host by microbial challenge and how dysregulation of these processes contributes to disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/wdev.344
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http://dx.doi.org/10.1002/wdev.344DOI Listing
April 2019
1 Read

Expression of NK genes that are not part of the NK cluster in the onychophoran Euperipatoides rowelli (Peripatopsidae).

BMC Dev Biol 2019 04 15;19(1). Epub 2019 Apr 15.

Department of Zoology, Institute of Biology, University of Kassel, Kassel, Germany.

Background: NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. They are typically divided into two subgroups, the NK cluster (NKC) and NK-linked genes (NKL). While the NKC genes have been studied in various bilaterians, corresponding data of many NKL genes are missing to date. Read More

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http://dx.doi.org/10.1186/s12861-019-0185-9DOI Listing

Insights into regeneration tool box: An animal model approach.

Dev Biol 2019 Apr 12. Epub 2019 Apr 12.

Department of Biology, University of Dayton, Dayton, OH 45469, USA; Premedical Program, University of Dayton, Dayton, OH 45469, USA; Center for Tissue Regeneration and Engineering at Dayton (TREND), University of Dayton, Dayton, OH 45469, USA; The Integrative Science and Engineering Center, University of Dayton, Dayton, OH 45469, USA; Center for Genomic Advocacy (TCGA), Indiana State University, Terre Haute, IN, USA. Electronic address:

For ages, regeneration has intrigued countless biologists, clinicians, and biomedical engineers. In recent years, significant progress made in identification and characterization of a regeneration tool kit has helped the scientific community to understand the mechanism(s) involved in regeneration across animal kingdom. These mechanistic insights revealed that evolutionarily conserved pathways like Wnt, Notch, Hedgehog, BMP, and JAK/STAT are involved in regeneration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606193010
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http://dx.doi.org/10.1016/j.ydbio.2019.04.006DOI Listing
April 2019
3 Reads

A chromosome-scale genome assembly and dense genetic map for Xenopus tropicalis.

Dev Biol 2019 Apr 10. Epub 2019 Apr 10.

University of California, Berkeley, Department of Molecular and Cell Biology, Life Sciences Addition, Berkeley, CA 94720-3200, USA; Joint Genome Institute, 2800 Mitchell Dr # 100, Walnut Creek, CA 94598, USA; Molecular Genetics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 9040495, Japan. Electronic address:

The Western clawed frog Xenopus tropicalis is a diploid model system for both frog genetics and developmental biology, complementary to the paleotetraploid X. laevis. Here we report a chromosome-scale assembly of the X. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.015DOI Listing

Defects in intervertebral disc and spine during development, degeneration, and pain: New research directions for disc regeneration and therapy.

Wiley Interdiscip Rev Dev Biol 2019 Apr 11:e343. Epub 2019 Apr 11.

Orthopedic Soft Tissue Research Program, Hospital for Special Surgery, New York, New York.

Intervertebral discs are cartilaginous joints present between vertebrae. The centers of the intervertebral discs consist of a gelatinous nucleus pulposus derived from the embryonic notochord. With age or injury, intervertebral discs may degenerate, causing neurological symptoms including back pain, which affects millions of people worldwide. Read More

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http://dx.doi.org/10.1002/wdev.343DOI Listing
April 2019
1 Read

Mechanisms of physiological tissue remodeling in animals: Manipulating tissue, organ, and organism morphology.

Dev Biol 2019 Apr 8. Epub 2019 Apr 8.

Allen Discovery Center, Department of Biology, Tufts University, 200 Boston Ave., Suite 4700, Medford, MA, 02155, United States. Electronic address:

Tissue remodeling is broadly defined as the reorganization or restoration of existing tissues. Tissue remodeling processes are responsible for directing the development and maintenance of tissues, organs, and overall morphology of an organism. Therefore, studying the regulatory and mechanistic aspects of tissue remodeling allows one to decipher how tissue structure and function is manipulated in animals. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.04.001DOI Listing

Q&A single-cell branching - Maria Leptin.

Authors:
Sofia J Araújo

Dev Biol 2019 Apr 6. Epub 2019 Apr 6.

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http://dx.doi.org/10.1016/j.ydbio.2019.04.004DOI Listing

Single-cell branching morphogenesis: A special issue.

Authors:
Sofia J Araújo

Dev Biol 2019 Apr 6. Epub 2019 Apr 6.

Department of Genetics, Microbiology and Statistics, School of Biology, University of Barcelona, 08028 Barcelona, Spain; Institute of Biomedicine University of Barcelona (IBUB), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.04.003DOI Listing

FGF10 is an essential regulator of tracheal submucosal gland morphogenesis.

Dev Biol 2019 Apr 6. Epub 2019 Apr 6.

Centre for Craniofacial and Regenerative Biology, Guy's Hospital, King's College London, United Kingdom. Electronic address:

Mucus secretion and mucociliary clearance are crucial processes required to maintain pulmonary homeostasis. In the trachea and nasal passages, mucus is secreted by submucosal glands (SMGs) that line the airway, with an additional contribution from goblet cells of the surface airway epithelium. The SMG mucus is rich in mucins and antimicrobial enzymes. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.017DOI Listing
April 2019
1 Read

Commentary on "Regeneration, duplication and transdetermination in fragments of the leg disc of Drosophila melanogaster": Schubiger, G. (1971).

Authors:
Matthew C Gibson

Dev Biol 2019 May;449(2):63-82

Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.

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http://dx.doi.org/10.1016/j.ydbio.2019.03.012DOI Listing

GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis.

Dev Biol 2019 Apr 3. Epub 2019 Apr 3.

Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

Since 1967, it is known that the loss of GLI3 causes very severe defects in murine eye development. GLI3 is able to act as a transcriptional activator (GLI3-A) or as a transcriptional repressor (GLI3-R). Soon after the discovery of these GLI3 isoforms, the question arose which of the different isoforms is involved in eye formation - GLI3-A, GLI3-R or even both. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00121606183074
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http://dx.doi.org/10.1016/j.ydbio.2019.02.018DOI Listing
April 2019
2 Reads

Clec14a genetically interacts with Etv2 and Vegf signaling during vasculogenesis and angiogenesis in zebrafish.

BMC Dev Biol 2019 04 5;19(1). Epub 2019 Apr 5.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.

Background: C-lectin family 14 Member A (Clec14a) is a transmembrane protein specifically expressed in vascular endothelial cells during embryogenesis. Previous in vitro and in vivo studies have provided conflicting data regarding Clec14a role in promoting or inhibiting angiogenesis, therefore its functional role in vascular development remains poorly understood.

Results: Here we have generated a novel clec14a mutant allele in zebrafish embryos using TALEN genome editing. Read More

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http://dx.doi.org/10.1186/s12861-019-0188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451255PMC

Differential contribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery.

Dev Biol 2019 Apr 2. Epub 2019 Apr 2.

State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210061, China. Electronic address:

During mouse development, part of the cells derived from the second heart field (SHF) progenitors contributes to the elongation and enlargement of the outflow tract (OFT) that subsequently septates into the trunks of aorta (Ao) and pulmonary artery (PA). Thus, the cardiac progenitor-originated cells are distributed to both Ao and PA. Here, we investigated that how these cells are assigned to the two great arteries during OFT septation through lineage tracing technology. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.019DOI Listing
April 2019
1 Read
3.547 Impact Factor

Developmental origins and oncogenic pathways in malignant brain tumors.

Wiley Interdiscip Rev Dev Biol 2019 Apr 3:e342. Epub 2019 Apr 3.

Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University, Chengdu, China.

Brain tumors such as adult glioblastomas and pediatric high-grade gliomas or medulloblastomas are among the leading causes of cancer-related deaths, exhibiting poor prognoses with little improvement in outcomes in the past several decades. These tumors are heterogeneous and can be initiated from various neural cell types, contributing to therapy resistance. How such heterogeneity arises is linked to the tumor cell of origin and their genetic alterations. Read More

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http://dx.doi.org/10.1002/wdev.342DOI Listing
April 2019
2 Reads

Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration.

Dev Biol 2019 Mar 30. Epub 2019 Mar 30.

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, CB2 3DY, UK. Electronic address:

Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.016DOI Listing
March 2019
1 Read

Trim33 is required for appropriate development of pre-cardiogenic mesoderm.

Dev Biol 2019 Mar 30. Epub 2019 Mar 30.

Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

Congenital cardiac malformations are among the most common birth defects in humans. Here we show that Trim33, a member of the Tif1 subfamily of tripartite domain containing transcriptional cofactors, is required for appropriate differentiation of the pre-cardiogenic mesoderm during a narrow time window in late gastrulation. While mesoderm-specific Trim33 mutants did not display noticeable phenotypes, epiblast-specific Trim33 mutant embryos developed ventricular septal defects, showed sparse trabeculation and abnormally thin compact myocardium, and died as a result of cardiac failure during late gestation. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.018DOI Listing

Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo.

Dev Biol 2019 Mar 29. Epub 2019 Mar 29.

Department of Biology, Virginia Commonwealth University, 1000 West Cary St., Richmond, VA 23284, United States. Electronic address:

Desmoplakin (Dsp) is a unique and critical desmosomal protein, that is integral to epidermal development. However, it is unclear whether this protein is required specifically for epidermal morphogenesis. Using morpholinos or Crispr/Cas9 mutagenesis we decreased the function of Dsp in frog embryos to better understand its role during epidermal development. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.010DOI Listing
March 2019
1 Read

Lack of Cyclin B1 in zebrafish causes lengthening of G2 and M phases.

Dev Biol 2019 Mar 28. Epub 2019 Mar 28.

Department of Biological Sciences, Western Michigan University, Kalamazoo, MI, 49008, USA.

An essential part of the Mitosis Promoting Factor, Cyclin B1 is indispensable for cells to enter mitosis. We report here that the zebrafish early arrest mutant specter is a loss-of-function mutation in the сyclin B1 gene. cyclin B1 is maternally transcribed in zebrafish, and the zygotic phenotype is apparent by early segmentation. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.014DOI Listing

Segmentation clock dynamics is strongly synchronized in the forming somite.

Dev Biol 2019 Mar 27. Epub 2019 Mar 27.

Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany; Max Planck Institute for the Physics of Complex Systems, 01187, Dresden, Germany; Tata Institute of Fundamental Research, 400005, Mumbai, India. Electronic address:

During vertebrate somitogenesis an inherent segmentation clock coordinates the spatiotemporal signaling to generate segmented structures that pattern the body axis. Using our experimental and quantitative approach, we study the cell movements and the genetic oscillations of her1 expression level at single-cell resolution simultaneously and scale up to the entire pre-somitic mesoderm (PSM) tissue. From the experimentally determined phases of PSM cellular oscillators, we deduced an in vivo frequency profile gradient along the anterior-posterior PSM axis and inferred precise mathematical relations between spatial cell-level period and tissue-level somitogenesis period. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.008DOI Listing

Understanding the marvels behind liver regeneration.

Wiley Interdiscip Rev Dev Biol 2019 May 28;8(3):e340. Epub 2019 Mar 28.

Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, Minnesota.

Tissue regeneration is a process by which the remaining cells of an injured organ regrow to offset the missed cells. This field is relatively a new discipline that has been a focus of intense research by clinicians, surgeons, and scientists for decades. It constitutes the cornerstone of tissue engineering, creation of artificial organs, and generation and utilization of therapeutic stem cells to undergo transformation to different types of mature cells. Read More

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http://dx.doi.org/10.1002/wdev.340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457252PMC

Development of the hematopoietic system: Role of inflammatory factors.

Wiley Interdiscip Rev Dev Biol 2019 Mar 27:e341. Epub 2019 Mar 27.

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

Hematopoietic stem cells (HSCs) have two defining features, multipotency and self-renewal, both of which are tightly controlled by cell autonomous programs and environmental factors throughout the lifetime of an organism. During development, HSCs are born in the aorta-gonad-mesonephros region, and migrate to distinct hematopoietic organs such as the placenta, fetal liver and spleen, continuously self-renewing and expanding to reach a homeostatic number. HSCs ultimately seed the bone marrow around the time of birth and become dormant to sustain lifelong hematopoiesis. Read More

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http://dx.doi.org/10.1002/wdev.341DOI Listing
March 2019
2 Reads

miR-29c regulates neurogliogenesis in the mammalian retina through REST.

Dev Biol 2019 Mar 23. Epub 2019 Mar 23.

Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address:

In the developing central nervous system, including its simple and accessible model retina, neurogenesis is followed by gliogenesis. However, the mechanism underlying the neurogliogenic switch remains poorly understood despite the identification of several regulatory genes, associated with the lineage identity and transition. The mechanism may involve cross talks between regulatory genes, facilitated through microRNAs. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.013DOI Listing
March 2019
1 Read

Apical constriction is necessary for crypt formation in small intestinal organoids.

Dev Biol 2019 Mar 23. Epub 2019 Mar 23.

AMOLF, Science Park 104, 1098 XG Amsterdam, the Netherlands. Electronic address:

Small intestinal organoids have become an important tool to study crypt homeostasis, cell fate dynamics and tissue biomechanics. Yet, the mechanisms that drive the budding of crypts from the smooth organoid epithelium remain incompletely understood. Locally enhanced proliferation has been suggested to induce tissue buckling and crypt initiation. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.009DOI Listing

Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.

Dev Biol 2019 Mar 23. Epub 2019 Mar 23.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address:

Inverse gradients of transcriptional repressors antagonize the transcriptional effector response to morphogens. However, the role of such inverse regulation might not manifest solely from lack of repressors. Sonic hedgehog (Shh) patterns the forebrain by being expressed ventrally; however, absence of antagonizing Gli3 repressor paradoxically cause insufficient pathway activation. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.011DOI Listing

Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development.

BMC Dev Biol 2019 03 25;19(1). Epub 2019 Mar 25.

Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.

Background: The embryonic day E10-13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiated by the formation of the epicardium on the outer heart surface, which releases insulin-like growth factor 2 (IGF2) as the primary cardiomyocyte mitogen. Two receptors mediate IGF2 signaling, the IGF1R and the insulin receptor (INSR). Read More

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http://dx.doi.org/10.1186/s12861-019-0186-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434851PMC

Gap junction-dependent coordination of intercellular calcium signalling in the developing appendicularian tunicate Oikopleura dioica.

Dev Biol 2019 Mar 21. Epub 2019 Mar 21.

Sars International Centre for Marine Molecular Biology, University of Bergen, Norway; Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway. Electronic address:

We characterized spontaneous Ca2+ signals in Oikopleura dioica embryos from pre-fertilization to gastrula stages following injection of GCaMP6 mRNA into unfertilized eggs. The unfertilized egg exhibited regular, transient elevations in intracellular Ca2+ concentration with an average duration of 4-6 s and an average frequency of about 1 every 2.5 min. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.006DOI Listing

Commentary on Tam and Zhou, 1996.

Authors:
Philippe Soriano

Dev Biol 2019 Mar;447(2):127-136

Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1016/j.ydbio.2019.02.006DOI Listing

Riding the crest for 150 years!

Authors:
Marianne Bronner

Dev Biol 2018 Dec;444 Suppl 1:S1-S2

California Institute of Technology, Pasadena, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.03.001DOI Listing
December 2018

Multiplex clonal analysis in the chick embryo using retrovirally-mediated combinatorial labeling.

Dev Biol 2019 Mar 15. Epub 2019 Mar 15.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

Lineage analysis plays a central role in exploring the developmental potential of stem and progenitor cell populations. In higher vertebrates, a variety of techniques have been used to label individual cells or cell populations, including interspecies grafting, intracellular microinjection, and Cre-mediated recombination. However, these approaches often suffer from difficulties in progenitor cell targeting, low cellular resolution and/or ectopic labeling. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.007DOI Listing

Commentary on cell polarity in plants: Quatrano 1973.

Authors:
Vivian Irish

Dev Biol 2019 Apr;448(1):1-6

Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Ave., New Haven, CT 06520-8104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.02.013DOI Listing

Rab11 is required for neurite pruning and developmental membrane protein degradation in Drosophila sensory neurons.

Dev Biol 2019 Mar 11. Epub 2019 Mar 11.

Institute for Neurobiology, University of Münster, Badestrasse 9, 48149, Münster, Germany. Electronic address:

Neurons, with their distinct neurites, require elaborate membrane trafficking pathways and regulation to uphold neurite identity and to be able to respond to neuronal or developmental stimuli. In a survey of trafficking regulators required for developmental dendrite pruning in Drosophila sensory neurons, we identified the small GTPase Rab11, a regulator of recycling endosomes. Dendrite pruning requires the developmentally regulated degradation of the cell adhesion molecule Neuroglian, and loss of Rab11 causes defects in the developmental degradation of Neuroglian and another target, the ion channel Ppk26. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.003DOI Listing

Development of the brain vasculature and the blood-brain barrier in zebrafish.

Dev Biol 2019 Mar 9. Epub 2019 Mar 9.

University of Muenster, Muenster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Muenster, Germany; Max Planck Institute for Molecular Biomedicine, Muenster, Germany. Electronic address:

To ensure tissue homeostasis the brain needs to be protected from blood-derived fluctuations or pathogens that could affect its function. Therefore, the brain capillaries develop tissue-specific properties to form a selective blood-brain barrier (BBB), allowing the passage of essential molecules to the brain and blocking the penetration of potentially harmful compounds or cells. Previous studies reported the presence of this barrier in zebrafish. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.005DOI Listing

Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway.

Dev Biol 2019 Mar 9. Epub 2019 Mar 9.

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Canada; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Development of an organism requires accurate coordination between the growth of a tissue and orientation of cells within the tissue. The large cadherin Fat has been shown to play a role in both of these processes. Fat is involved in the establishment of planar cell polarity and regulates growth through the Hippo pathway, a developmental cascade that controls proliferation and apoptosis. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.004DOI Listing

Roles of Polycomb group proteins Enhancer of zeste (E(z)) and Polycomb (Pc) during metamorphosis and larval leg regeneration in the flour beetle Tribolium castaneum.

Dev Biol 2019 Mar 7. Epub 2019 Mar 7.

Department of Biological Sciences, Wellesley College, 106 Central St., Wellesley, MA 02481, USA. Electronic address:

Many organisms both undergo dramatic morphological changes during post-embryonic development and also regenerate lost structures, but the roles of epigenetic regulators in such processes are only beginning to be understood. In the present study, the functions of two histone modifiers were examined during metamorphosis and larval limb regeneration in the red flour beetle Tribolium castaneum. Polycomb (Pc), a member of Polycomb repressive complex 1 (PRC1), and Enhancer of zeste (E(z)), a member of Polycomb repressive complex 2 (PRC2), were silenced in larvae using RNA interference. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.03.002DOI Listing

Vitellogenins in the spider Parasteatoda tepidariorum - expression profile and putative hormonal regulation of vitellogenesis.

BMC Dev Biol 2019 03 8;19(1). Epub 2019 Mar 8.

Department of Animal Physiology and Ecotoxicology, University of Silesia, Bankowa 9, PL40007, Katowice, Poland.

Background: Knowledge about vitellogenesis in spiders is rudimentary. Therefore, the aim of study was to check the vitellogenin (Vg) presence in various tissues of the female spider Parasteatoda tepidariorum, determine when and where vitellogenesis starts and takes place, and the putative role of selected hormones in the vitellogenesis.

Results: Here we show two genes encoding Vg (PtVg4 and PtVg6) in the genome of the spider P. Read More

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http://dx.doi.org/10.1186/s12861-019-0184-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408786PMC

Decapentaplegic function in wing vein development and wing morph transformation in brown planthopper, Nilaparvata lugens.

Dev Biol 2019 May 4;449(2):143-150. Epub 2019 Mar 4.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China. Electronic address:

The decapentaplegic (dpp) gene plays a variety of roles in diverse cellular and molecular processes of the growth and development. In insects, dpp is mainly required for dorsal-ventral patterning and appendage formation. The brown planthopper (BPH) Nilaparvata lugens, a major pest of rice, possesses two distinct wing morphs described as long-winged (LW) and short-winged (SW) morphs. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.016DOI Listing

Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms.

BMC Dev Biol 2019 03 7;19(1). Epub 2019 Mar 7.

D'Or Institute for Research and Education (IDOR), Rua Diniz Cordeiro, 30 - Botafogo, Rio de Janeiro, RJ, 22281-100, Brazil.

Background: Organoid cultivation in suspension culture requires agitation at low shear stress to allow for nutrient diffusion, which preserves tissue structure. Multiplex systems for organoid cultivation have been proposed, but whether they meet similar shear stress parameters as the regularly used spinner flask and its correlation with the successful generation of brain organoids has not been determined.

Results: Here we used computational fluid dynamics (CFD) to simulate two multiplex culture conditions: steering plates on an orbital shaker and the use of a previously described bioreactor. Read More

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http://dx.doi.org/10.1186/s12861-019-0183-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404276PMC
March 2019
2 Reads
2.667 Impact Factor

Hyphal branching in filamentous fungi.

Authors:
Steven D Harris

Dev Biol 2019 Mar 1. Epub 2019 Mar 1.

Department of Biological Sciences, University of Manitoba, 212 Biological Sciences Building, Winnipeg, MB, R3T 2N2, Canada. Electronic address:

In filamentous fungi, the formation of hyphal branches is a critical process that supports the ability of mycelia to radiate across and colonize growth substrates. Branching can occur at hyphal tips (apical branching) or from subapical hyphal compartments (lateral branching). The primary focus of this review is on lateral branching. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.012DOI Listing
March 2019
3 Reads

Myosin heavy chain mutations that cause Freeman-Sheldon syndrome lead to muscle structural and functional defects in Drosophila.

Dev Biol 2019 May 28;449(2):90-98. Epub 2019 Feb 28.

Laboratory of Developmental Genetics, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad, Haryana, 121001, India; Affiliated to Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. Electronic address:

Missense mutations in the MYH3 gene encoding myosin heavy chain-embryonic (MyHC-embryonic) have been reported to cause two skeletal muscle contracture syndromes, Freeman Sheldon Syndrome (FSS) and Sheldon Hall Syndrome (SHS). Two residues in MyHC-embryonic that are most frequently mutated, leading to FSS, R672 and T178, are evolutionarily conserved across myosin heavy chains in vertebrates and Drosophila. We generated transgenic Drosophila expressing myosin heavy chain (Mhc) transgenes with the FSS mutations and characterized the effect of their expression on Drosophila muscle structure and function. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.017DOI Listing
May 2019
2 Reads
3.547 Impact Factor

Human neural crest induction by temporal modulation of WNT activation.

Dev Biol 2019 May 1;449(2):99-106. Epub 2019 Mar 1.

Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California, USA. Electronic address:

The developmental biology of neural crest cells in humans remains unexplored due to technical and ethical challenges. The use of pluripotent stem cells to model human neural crest development has gained momentum. We recently introduced a rapid chemically defined approach to induce robust neural crest by WNT/β-CATENIN activation. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.015DOI Listing

Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls.

Dev Biol 2019 May 28;449(2):122-131. Epub 2019 Feb 28.

Institute of Biotechnology, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan. Electronic address:

Axolotls have amazing abilities to regenerate their lost limbs. Nerve and wound epidermis have great impacts on this regeneration. Histone deacetylases (HDACs) have been shown to play roles in the regeneration of amphibian tails and limbs. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.011DOI Listing

CDX4 regulates the progression of neural maturation in the spinal cord.

Dev Biol 2019 May 28;449(2):132-142. Epub 2019 Feb 28.

Department of Biology, University of Miami, 1301 Memorial Drive, Coral Gables, Florida, 33146, United States; Department of Biology, University of Richmond, 138 UR Drive B322, Richmond, VA, 23173, United States. Electronic address:

The progression of cells down different lineage pathways is a collaborative effort between networks of extracellular signals and intracellular transcription factors. In the vertebrate spinal cord, FGF, Wnt and Retinoic Acid signaling pathways regulate the progressive caudal-to-rostral maturation of neural progenitors by regulating a poorly understood gene regulatory network of transcription factors. We have mapped out this gene regulatory network in the chicken pre-neural tube, identifying CDX4 as a dual-function core component that simultaneously regulates gradual loss of cell potency and acquisition of differentiation states: in a caudal-to-rostral direction, CDX4 represses the early neural differentiation marker Nkx1. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.014DOI Listing
May 2019
3 Reads

Pharmacological restoration of visual function in a zebrafish model of von-Hippel Lindau disease.

Dev Biol 2019 Feb 27. Epub 2019 Feb 27.

UCD School of Biomolecular & Biomedical Science, UCD Conway Institute, University College Dublin, D04 V1W8, Ireland. Electronic address:

Von Hippel-Lindau (VHL) syndrome is a rare, autosomal dominant disorder, characterised by hypervascularised tumour formation in multiple organ systems. Vision loss associated with retinal capillary hemangioblastomas remains one of the earliest complications of VHL disease. The mortality of Vhl mice in utero restricted modelling of VHL disease in this mammalian model. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.008DOI Listing
February 2019

Ci-hox12 tail gradient precedes and participates in the control of the apoptotic-dependent tail regression during Ciona larva metamorphosis.

Dev Biol 2019 Feb 25. Epub 2019 Feb 25.

Sorbonne Université, CNRS, Institut de Biologie Paris Seine, IBPS, Evolution Paris Seine, F-75252 Paris Cedex 05, France. Electronic address:

At the onset of the Ciona intestinalis metamorphosis, the first event is tail regression characterized, by a contraction, an apoptotic wave and Primordial Germ Cells (PGC) movement. All these cell behaviors originate from the posterior tail tip and progress to the anterior. Interestingly, earlier in Ciona development, the antero-posterior (A/P) patterning of the tailbud epidermis depends on two antagonist gradients, respectively FGF/MAPK at the posterior and retinoic acid (RA) at the anterior part of the tail. Read More

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http://dx.doi.org/10.1016/j.ydbio.2018.12.010DOI Listing
February 2019
2 Reads

Tunicates: From humble sea squirt to proud model organism.

Dev Biol 2019 Feb 22. Epub 2019 Feb 22.

Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.

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http://dx.doi.org/10.1016/j.ydbio.2019.02.007DOI Listing
February 2019
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MiR-124 regulates transforming growth factor-β1 induced differentiation of lung resident mesenchymal stem cells to myofibroblast by repressing Wnt/β-catenin signaling.

Dev Biol 2019 May 22;449(2):115-121. Epub 2019 Feb 22.

Department of Respiratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No 600 Yishan Road, Shanghai 200233, China. Electronic address:

Lung resident mesenchymal stem cells (LR-MSCs) contribute to the progression of idiopathic pulmonary fibrosis (IPF). We aimed to investigate the molecular mechanism underlying LR-MSCs regulation upon transforming growth factor (TGF)-β1 stimulation. We induced fibrogenic differentiation of LR-MSCs isolated from mice by TGF-β1. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.010DOI Listing

The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis.

Dev Biol 2019 May 21;449(1):1-13. Epub 2019 Feb 21.

Institute for Biochemistry and Molecular Biology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Electronic address:

Wnt proteins can activate different intracellular signaling pathways. These pathways need to be tightly regulated for proper cardiogenesis. The canonical Wnt/β-catenin inhibitor Dkk1 has been shown to be sufficient to trigger cardiogenesis in gain-of-function experiments performed in multiple model systems. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.02.009DOI Listing