2,637,074 results match your criteria Development and Psychopathology [Journal]


MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3.

Yonsei Med J 2019 Jan;60(1):22-29

Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Purpose: It is well documented that natural killer (NK) cytotoxicity against hepatocellular carcinoma (HCC) cells is impaired in HCC, which might account for the failure of anti-tumor immune response. miRNAs are considered as important regulators for the development and functions of NK cells. However, the entire role of miR-506 in NK cells remains far from being addressed. Read More

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January 2019

Behavioral and Imaging Studies of Infant Artificial Grammar Learning.

Top Cogn Sci 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, University of Arizona.

Artificial grammar learning (AGL) paradigms have proven to be productive and useful to investigate how young infants break into the grammar of their native language(s). The question of when infants first show the ability to learn abstract grammatical rules has been central to theoretical debates about the innate vs. learned nature of grammar. Read More

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December 2018
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Genomic sequence capture of haemosporidian parasites: Methods and prospects for enhanced study of host-parasite evolution.

Mol Ecol Resour 2018 Dec 16. Epub 2018 Dec 16.

Museum of Southwestern Biology and Department of Biology, MSC03 2020, 1 University of New Mexico, Albuquerque, New Mexico, 87131-0001, USA.

Avian malaria and related haemosporidians (Plasmodium, [Para]Haemoproteus, and Leucocytoozoon) represent an exciting multi-host, multi-parasite system in ecology and evolution. Global research in this field accelerated after 1) the publication in 2000 of PCR protocols to sequence a haemosporidian mitochondrial (mtDNA) barcode, and 2) the development in 2009 of an open-access database to document the geographic and host ranges of parasite mtDNA haplotypes. Isolating haemosporidian nuclear DNA from bird hosts, however, has been technically challenging, slowing the transition to genomic-scale sequencing techniques. Read More

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December 2018

CCN1 regulates cholesterol metabolism - OxLDL enters the matrix.

Acta Physiol (Oxf) 2018 Dec 16:e13239. Epub 2018 Dec 16.

Heart Center Bonn, Medical Department II, University Hospital Bonn, Sigmund-Freud-Str. 2553127, Bonn, Germany.

In the present issue of Acta physiologica, Zhao et al. publish an article, in which they investigate how the extracellular matrix protein CCN1 regulates cholesterol efflux from macrophages in atherosclerotic plaques and biliary excretion of cholesterol in the liver.1 The development of atherosclerotic plaques is a primarily inflammatory process, which is triggered by well-established risk factors including arterial hypertension, diabetes, hypercholesterolemia and smoking. Read More

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December 2018
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Movement Segmentation and Visual Perturbation Increase Developmental Differences in Motor Control and Learning.

Dev Sci 2018 Dec 16:e12789. Epub 2018 Dec 16.

Laboratory of Neuromotor Control and Learning, Shenzhen University, Shenzhen, 518060, P.R. China.

We examined the developmental differences in motor control and learning of a two-segment movement. One hundred and five participants (53 female) were divided into three age groups (7 to 8 years, 9 to 10 years and 19 to 27 years). They performed a two-segment movement task in four conditions (full vision, fully disturbed vision, disturbed vision in the first movement segment and disturbed vision in the second movement segment). Read More

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December 2018

Dementia-friendly community initiatives: An integrative review.

J Clin Nurs 2018 Dec 16. Epub 2018 Dec 16.

University of Canberra, 3. Stephen Neville.

Aim: To synthesise international research conducted on dementia-friendly community initiatives.

Background: The number of people living with dementia is increasing as a result of population ageing. Impairments related to neurological changes, together with environmental challenges result in disability for people who have dementia. Read More

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December 2018

Origin site-based staging system of sinonasal inverted papilloma for application to endoscopic sinus surgery.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Background: We aimed to assess the recurrence risk of sinonasal inverted papillomas (SNIPs), based on a staging system developed according to the originating site of SNIP.

Methods: A total of 200 patients with SNIP were enrolled, and a staging system was developed based on the originating sites and corresponding recurrence rates of tumor in the patients. In the verification phase, 675 patients with SNIPs were enrolled as above, and the originating sites of the SNIPs were confirmed by an endoscopic sinus surgery. Read More

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December 2018

Cases of prolonged mild disturbance of consciousness and acute encephalopathy.

Pediatr Int 2018 Dec 15. Epub 2018 Dec 15.

Division of Neurology, National Center for Child Health and Development, Tokyo, Japan 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Acute encephalopathy (AE) is defined by the Japanese guidelines as the acute disturbance of consciousness (Glasgow Coma Scale score ≤11) that persists for more than 24 hours. However, we have often encountered cases of prolonged mild disturbance of consciousness (PMDC) with Glasgow Coma Scale scores >11 that do not fit the definition of acute encephalopathy by the guidelines. The reports of these cases have been relatively sparse, and their nosological position, prognosis, and other characteristics remain unknown. Read More

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December 2018

Developmental mutant mouse models for external genitalia formation.

Congenit Anom (Kyoto) 2018 Nov 22. Epub 2018 Nov 22.

Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Wakayama, Japan.

Development of external genitalia and perineum is the subject of developmental biology as well as toxicology and teratology researches. Cloaca forms in the lower (caudal) end of endoderm. Such endodermal epithelia and surrounding mesenchyme interact with various signals to form the external genitalia. Read More

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November 2018

Deficits in Inhibitory Control May Place Service Members at Risk for Posttraumatic Stress Disorder and Negative Parenting Behavior Following Deployment-Related Trauma.

J Trauma Stress 2018 Dec;31(6):866-875

Institute of Child Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.

This study examined the mediating role of posttraumatic stress disorder (PTSD) symptoms in the association between deployment-related trauma exposure and parenting behaviors in reserve-component military service members and whether this association was contingent upon parent inhibitory control (IC). Participants were 181 postdeployed fathers and their children. Fathers completed a neurospychological test of IC and self-report measures of trauma exposure and PTSD symptoms. Read More

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December 2018

Advances in understanding obligate biotrophy in rust fungi.

New Phytol 2018 Dec 16. Epub 2018 Dec 16.

UMR 1136 INRA/Université de Lorraine Interactions Arbres/Microorganismes, INRA Centre Grand Est - Nancy, 54280, Champenoux, France.

Rust fungi (Pucciniales) are the largest group of plant pathogens and represent one of the most devastating threats to agricultural crops worldwide. Despite the economic importance of these highly specialized pathogens, many aspects of their biology remain obscure largely because rust fungi are obligate biotrophs. The rise of genomics and advances in high-throughput sequencing technology have presented new options for identifying candidate effector genes involved in pathogenicity mechanisms of rust fungi. Read More

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December 2018

Deficiencies in postoperative surveillance for veterans with gastrointestinal cancer.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

Department of Surgery, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.

Background And Objectives: National guidelines for gastrointestinal (GI) cancers offer surveillance algorithms to facilitate detection of recurrent disease, yet adherence rates are unknown. We sought to characterize postoperative surveillance patterns for veterans with GI cancer at a tertiary care Veterans Affairs Hospital.

Methods: A single-center retrospective cohort study identified patients who underwent surgical resection for colorectal, gastroesophageal or hepatopancreaticobiliary malignancy from 2010-2016. Read More

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December 2018

Arbuscular mycorrhizal fungi possess a CLAVATA3/Endosperm surrounding region-related gene that positively regulates symbiosis.

New Phytol 2018 Dec 16. Epub 2018 Dec 16.

Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, France.

The arbuscular mycorrhizal (AM) symbiosis is a beneficial association established between land plants and the members of a subphylum of fungi, the Glomeromycotina. How the two symbiotic partners regulate their association is still enigmatic. Secreted fungal peptides are candidates for regulating this interaction. Read More

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December 2018

Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells.

J Assist Reprod Genet 2018 Dec 15. Epub 2018 Dec 15.

Division of Reproductive Endocrinology and Infertility, Department of Reproductive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0633, USA.

Purpose: To compare effects of lipid-soluble statins (simvastatin, lovastatin, atorvastatin) and water-soluble statin (pravastatin) on growth and invasiveness of human endometrial stromal (HES) cells.

Methods: Endometrial biopsies were collected during the proliferative phase from five volunteers. HES cells were isolated and cultured in the absence or in the presence of simvastatin, lovastatin, atorvastatin, and pravastatin. Read More

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December 2018

Gut microbiome approaches to treat obesity in humans.

Appl Microbiol Biotechnol 2018 Dec 16. Epub 2018 Dec 16.

Department of Food and Nutrition, School of Pharmaceutical Sciences, State University of São Paulo (UNESP), Araraquara, SP, Brazil.

The rising worldwide prevalence of obesity has become a major concern having many implications for the public health and the economy. It is well known that many factors such as lifestyle, increased intake of foods high in fat and sugar and a host's genetic profile can lead to obesity. Besides these factors, recent studies have pointed to the gut microbiota composition as being responsible for the development of obesity. Read More

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December 2018

The effect of hyperosmolality application time on production, quality, and biopotency of monoclonal antibodies produced in CHO cell fed-batch and perfusion cultures.

Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

Shanghai Taiyin Biotech Co., Ltd., Shanghai, 201203, China.

Hyperosmolality has been commonly investigated due to its effects on the production and quality characteristics of monoclonal antibodies (mAbs) produced in CHO cell fed-batch cultures. However, the application of hyperosmolality at different times and its effect on biopotency have seldom been researched, especially in perfusion culture. In our study, different degrees of hyperosmolality induced by sodium chloride were investigated in anti-IgE rCHO cell fed-batch cultures and anti-CD52 rCHO cell perfusion cultures during the initial and stable phases. Read More

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December 2018

The effects of a 12-week jump rope exercise program on abdominal adiposity, vasoactive substances, inflammation, and vascular function in adolescent girls with prehypertension.

Eur J Appl Physiol 2018 Dec 15. Epub 2018 Dec 15.

Department of Physical Education, Pusan National University, Busan, South Korea.

Introduction: Childhood obesity is strongly associated with cardiovascular disease (CVD) development. It is necessary to combat unfavorable outcomes of obesity at a young age by utilizing effective interventions, such as exercise.

Purpose: We sought to examine the effects of a jump rope exercise program on CVD risk factors, including body composition, vasoactive substances, inflammation, and vascular function in prehypertensive adolescent girls. Read More

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December 2018
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Melanoma-related changes in skin microbiome.

Folia Microbiol (Praha) 2018 Dec 15. Epub 2018 Dec 15.

Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague, Czech Republic.

Melanoma is the least common form of skin tumor, but it is potentially the most dangerous and responsible for the majority of skin cancer deaths. We suggest that the skin microbiome might be changed during the progression of melanoma. The aim of this study is to compare the composition of the skin microbiota between different locations (skin and melanoma) of a MeLiM (Melanoma-bearing Libechov Minipig) pig model (exophytic melanoma). Read More

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December 2018
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Pollen grain development and male sterility in the perfect flowers of Maytenus obtusifolia Mart. (Celastraceae).

Protoplasma 2018 Dec 15. Epub 2018 Dec 15.

Departamento de Botânica, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, SP, 18618-000, Brazil.

Perfect flowers of Maytenus obtusifolia have partial sterility of pollen grains, resulting in collapsed and developed free microspores. However, the cellular events resulting in partial male sterility have not been determined. In pistillate flowers of this species, male sterility is related to the premature programmed cell death (PCD) in tapetum and sporogenic cells. Read More

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December 2018

Cancer control planning: self-assessment for pre-planning, development, implementation and evaluation of national cancer control plans.

Cancer Causes Control 2018 Dec 15. Epub 2018 Dec 15.

National Cancer Institute, Rockville, MD, USA.

The development of cancer control plans as a clearly defined concept began in the U.S. in the early 1990s. Read More

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December 2018

Resveratrol Protects Against Renal Damage via Attenuation of Inflammation and Oxidative Stress in High-Fat-Diet-Induced Obese Mice.

Inflammation 2018 Dec 15. Epub 2018 Dec 15.

College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.

Oxidative stress and inflammation play an important role in the chronic kidney disease associated with obesity. Resveratrol (RSV) has been reported to exhibit a wide range of biological activities including antioxidant and anti-inflammatory properties. The objective of the present study was to investigate the effects of RSV on renal inflammation and oxidative stress in obese mice induced by high-fat diet. Read More

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December 2018

Neurocognitive and functional outcomes at 5 years of age after renal transplant in early childhood.

Pediatr Nephrol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Edmonton Clinic Health Academy, University of Alberta, 11405 - 87 Ave, Edmonton, AB, T6G 1C9, Canada.

Background: Clinicians often use information about developmental outcomes in decision-making around offering complex, life-saving interventions in children such as dialysis and renal transplant. This information in children with end-stage renal disease (ESRD) is limited, particularly when ESRD onset is in infancy or early childhood.

Methods: Using data from an ongoing prospective, longitudinal, inception cohort study of children with renal transplant before 5 years of age, we evaluated (1) the risk of adverse neurocognitive and functional outcomes at 5 years of age and (2) predictors of developmental outcomes. Read More

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December 2018

Metabolic requirements of the nephron.

Pediatr Nephrol 2018 Dec 15. Epub 2018 Dec 15.

Rangos Research Center, UPMC Children's Hospital of Pittsburgh, Pittsburgh, USA.

The mammalian kidney is a complex organ that has several metabolically active cell types to aid in waste filtration, salt-water balance, and electrolyte homeostasis in the body. These functions are done primarily through the nephron, which relies on strict regulation of various metabolic pathways. Any deviations in the metabolic profile of nephrons or their precursor cells called nephron progenitors can lead to renal pathologies and abnormal development. Read More

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December 2018
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Functional roles of Grainyhead-like transcription factors in renal development and disease.

Pediatr Nephrol 2018 Dec 15. Epub 2018 Dec 15.

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125, Berlin, Germany.

Proper renal function relies on the tightly regulated development of nephrons and collecting ducts. This process, known as tubulogenesis, involves dynamic cellular and molecular changes that instruct cells to form highly organized tubes of epithelial cells which compartmentalize the renal interstitium and tubular lumen via assembly of a selective barrier. The integrity and diversity of the various renal epithelia is achieved via formation of intercellular protein complexes along the apical-basal axis of the epithelial cells. Read More

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December 2018
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Developmental Relations Between Listening and Reading Comprehension in Young Chinese Language Learners: A Longitudinal Study.

Authors:
Yu Ka Wong

J Psycholinguist Res 2018 Dec 15. Epub 2018 Dec 15.

Department of Curriculum and Instruction, Faculty of Education, The Chinese University of Hong Kong, Shatin, Hong Kong.

The reciprocal influences between the development of Chinese-as-a-second-language (CSL) listening and reading comprehension among young learners in Hong Kong were evaluated using a 2-year, three-wave longitudinal design. A total of 129 senior primary CSL students were assessed using listening and reading comprehension tests at the end of grades 4, 5, and 6. An autoregressive, cross-lagged model was specified, and it accounted for a substantial portion of variance (more than 60%) in the two comprehension abilities by grades 5 and 6. Read More

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December 2018

Autism in India: a case-control study to understand the association between socio-economic and environmental risk factors.

Acta Neurol Belg 2018 Dec 15. Epub 2018 Dec 15.

Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, 641 046, India.

Autism spectrum disorder is a neurodevelopmental disorder and the cause of autism is still unclear. The aim of this study was to investigate the association of socioeconomic, environmental, pregnancy and newborn-related risk factors among children with autism spectrum disorders. This was a population-based case-control study. Read More

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December 2018

Impact of large-scale tree planting in Yunnan Province, China, on the water supply balance in Southeast Asia.

Environ Monit Assess 2018 Dec 15;191(1):20. Epub 2018 Dec 15.

Chongqing College of Arts and Sciences, Chongqing, 402160, China.

Along with rapid economic development and population growth, anthropogenic disturbances to natural ecosystems increase the progressively worsening environmental problems in and around water resources, making the potential ecological risks more severe and unpredictable. In order to cope with the increasingly serious issues related to the ecological environment and poverty alleviation, the Government of Yunnan in Southwest China launched a large-scale afforestation campaign (plantation forestry) on the Yunnan-Guizhou Plateau, which is the main source of several major river systems in Southeast Asia. In this study, we use GIS to investigate the impacts of a large-scale afforestation on the water storage balance of Southeast Asia. Read More

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December 2018

Renoprotective effects of the novel prostaglandin EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized chronic kidney disease rats.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 15. Epub 2018 Dec 15.

Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki, 305-8585, Japan.

Prostaglandins (PGs) are important lipid mediators of numerous physiologic and pathophysiologic processes in the kidney. PGE, the most abundant renal PG, plays a major role in renal physiology, including renin release and glomerular hemodynamics. We investigated the renoprotective properties of the novel PGE EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized rats, a chronic kidney disease (CKD) model. Read More

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December 2018
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TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation.

Virchows Arch 2018 Dec 15. Epub 2018 Dec 15.

Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.

Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare variant of aggressive adenocarcinoma. We demonstrated previously that GAED is genetically characterized by frequent TP53 mutation. In this study, we aimed to further clarify the mechanism of inactivation of TP53 in GAED in the light of promoter methylation of TP53, and expression of methylation-associated proteins such as Ten-eleven translocation (TET) 1 and 5-hydroxymethylcytosine (5-hmc) in addition to ATM mutations. Read More

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December 2018

Evaluation of Physicochemical and Biological Stability of 36-Months-Aged SB5 (Adalimumab Biosimilar) for 4 Weeks at Room Temperature.

Adv Ther 2018 Dec 15. Epub 2018 Dec 15.

Analytical Method Development Team, Samsung Bioepis Co., Ltd., Incheon, South Korea.

Introduction: Tumor necrosis factor (TNF-alpha) inhibitors, such as adalimumab, have shown success in treating autoimmune inflammatory diseases but are associated with substantial financial burdens to the healthcare system. Biosimilars, which are highly similar to biologic agents, offer the potential to reduce the financial burden of treatment. In the case of TNF-alpha inhibitors, they may also offer improved stability and enable prolonged use. Read More

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December 2018

Deep sequencing salivary proteins for periodontitis using proteomics.

Clin Oral Investig 2018 Dec 15. Epub 2018 Dec 15.

Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Objectives: Saliva is a bodily fluid transuded from gingival crevice fluid and blood and contains many proteins. Proteins in saliva have been studied as markers for periodontal diseases. Mass spectrometric analysis is applied to investigate biomarker proteins that are related to periodontitis. Read More

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December 2018

Illumina MiSeq Sequencing Investigation of Microbiota in Bronchoalveolar Lavage Fluid and Cecum of the Swine Infected with PRRSV.

Curr Microbiol 2018 Dec 15. Epub 2018 Dec 15.

Institute of Immunology, College of Life Science and Technology, Dalian University, Dalian, 116622, Liaoning, China.

Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant animal morbidity and mortality and economic losses worldwide. In this study, we analyzed the microbiota in bronchoalveolar lavage fluid (BAL), mucosa, and feces in cecum of the PRRSV-challenged pigs using the Illumina MiSeq sequencing platform, to investigate the role of microbiota in the pathogenesis and development of porcine reproductive and respiratory syndrome (PRRS). Quantitative insights into microbial ecology analyses indicated that the dominant bacterial groups in the lung from the PRRSV-challenged pigs were Haemophilus parasuis and Mycoplasma hyorhinis, with a relative abundance of 35-48% and 27-41%, respectively. Read More

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December 2018

Development of a model for food waste composting.

Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.

Faculty of Food Engineering, Stefan cel Mare University of Suceava, 13 Universitatii Street, 720229, Suceava, Romania.

Worldwide, large amounts of food are wasted every year. Reducing of food waste at European level is taken very seriously and it has been adopted even a target of reducing the amount of food waste in half until 2030. In many countries of the European Union, food wastes are composted, while in countries like Romania, the composting is too little used or not at all, but efforts are being made to apply this process. Read More

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December 2018

Unraveling the sources and fluorescence compositions of dissolved and particulate organic matter (DOM and POM) in Lake Taihu, China.

Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.

Taihu Laboratory for Lake Ecosystem Research, State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, China.

Organic matter (OM), a complex entity with diverse functional groups and molecular sizes, has important effects on aquatic systems. We studied the optical compositions and sources of dissolved organic matter (DOM) and particulate organic matter (POM) in Lake Taihu, a large, shallow and eutrophic lake in China. Significant differences in optical compositions and sources occurred between the POM and DOM. Read More

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December 2018

Effects of biochar and dicyandiamide combination on nitrous oxide emissions from Camellia oleifera field soil.

Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.

Ministry of Education and Jiangxi Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Jiangxi Agricultural University, Nanchang, 330045, China.

Greenhouse gas emissions from agricultural soils contribute substantially to global atmospheric composition. Nitrous oxide (NO) is one important greenhouse gas induces global warming. Nitrification inhibitors (NI) or biochar can be effective soil NO emission mitigation strategies for agricultural soils. Read More

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December 2018

Explore the influence mechanism of carbon emissions decline on energy intensity with two-layer factor decomposition method in Beijing-Tianjin-Hebei region.

Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.

Department of Economics Management, North China Electric Power University, No. 689 Huadian Road, Baoding, 071003, China.

Understanding the intrinsic mechanism behind changes on energy intensity provides insights about reducing carbon emissions and promoting the sustainable development of Beijing-Tianjin-Hebei (BTH) region. Although various studies have found a causal relationship between energy intensity and energy-related carbon emissions, the internal mechanisms are still unclear. This paper presents a comprehensive analysis of the impact of energy intensity on carbon emissions from 2005 to 2015. Read More

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December 2018

Novel flourescent spiroborate esters: potential therapeutic agents in in vitro cancer models.

Mol Biol Rep 2018 Dec 15. Epub 2018 Dec 15.

Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India.

The current treatment system in cancer therapy, which includes chemotherapy/radiotherapy is expensive and often deleterious to surrounding healthy tissue. Presently, several medicinal plants and their constituents are in use to manage the development and progression of these diseases.They have been found effective, safe, and less expensive. Read More

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December 2018
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Family functioning, moods, and binge eating among urban adolescents.

J Behav Med 2018 Dec 15. Epub 2018 Dec 15.

School of Community and Global Health, Claremont Graduate University, 675 W. Foothill Blvd., Ste. 310, Claremont, CA, 91711, USA.

This study builds upon prior research on associations between moods, family functioning, and binge eating, using ecological momentary assessment to examine moderating effects of family functioning on associations between moods and binge eating. This study was conducted among a nonclinical sample of urban adolescents. Family functioning was assessed using five constructs adopted from the FACES-IV measure: 'family cohesion,' 'family flexibility' 'family communication,' 'family satisfaction,' and 'family balance. Read More

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December 2018

Rural population mobility, deforestation, and urbanization: case of Turkey.

Environ Monit Assess 2018 Dec 15;191(1):21. Epub 2018 Dec 15.

Department of Forest Engineering, Faculty of Forestry, Çankırı Karatekin University, 18200, Çankırı, Turkey.

The benefits of the forests are well known and are by their existence alone an amenity. Nonetheless, urbanization as one of the most remarkable features of social development has immense effects on forest resources and land use. In this study, it is hypothesized that there are temporal interactions among the rural population dynamics, urbanization, and forest resources. Read More

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December 2018

The maternal reward system in postpartum depression.

Arch Womens Ment Health 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH, USA.

The experience of motherhood is most often emotionally positive and rewarding, but for many new mothers suffering from postpartum depression (PPD), this is not the case. Preclinical and clinical research has sought to uncover brain changes underlying PPD in order to gain a better understanding of how this disorder develops. This review focuses on the mesolimbic dopamine system, particularly the ventral tegmental area-nucleus accumbens pathway which has been implicated in the regulation of critical functions disrupted in PPD including mood, motivation, and mothering. Read More

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December 2018

Interaction of H. pylori with toll-like receptor 2-196 to -174 ins/del polymorphism is associated with gastric cancer susceptibility in southern China.

Int J Clin Oncol 2018 Dec 15. Epub 2018 Dec 15.

Department of Gastroenterology, Changzhou No. 2 People's Hospital, Xinglong Xiang 29, Changzhou, 213000, Jiangsu, China.

Background: Genetic polymorphisms of Toll-like receptors play important roles in gastric carcinogenesis. The aim of this study was to determine the role of TLR2-196 to -174 ins/del polymorphism in gastric cancer susceptibility and prognosis.

Methods: This study included 520 people from southern China. Read More

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December 2018

A star-shaped molecularly imprinted polymer derived from polyhedral oligomeric silsesquioxanes with improved site accessibility and capacity for enantiomeric separation via capillary electrochromatography.

Mikrochim Acta 2018 Dec 15;186(1):22. Epub 2018 Dec 15.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.

A star-shaped molecularly imprinted coating was prepared starting from octavinyl-modified polyhedral oligomeric silsesquioxanes (Ov-POSS). It possesses a relatively open structure and has good site accessibility and a larger capacity even at lower cross-linking. The imprinted coating was prepared from S-amlodipine (S-AML) as the template and analyte, Ov-POSS as the cross-linker, and methacrylic acid as the functional monomer. Read More

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December 2018

Perceptions of dietary factors promoting and preventing nephrolithiasis: a cross-sectional survey.

World J Urol 2018 Dec 15. Epub 2018 Dec 15.

Department of Urology, NYU Langone Hospital-Brooklyn, Brooklyn, NY, USA.

Objective: To assess knowledge of both promoting and preventive dietary factors on nephrolithiasis in a diverse patient population. Precipitating factors of kidney stone disease include diet, lifestyle, socioeconomic status, and race/ethnicity. However, patient awareness of these influences is poorly described. Read More

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December 2018

Cyclic peptide RD808 reduces myocardial injury induced by β-adrenoreceptor autoantibodies.

Heart Vessels 2018 Dec 15. Epub 2018 Dec 15.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing, 100069, China.

Autoantibodies against the second extracellular loop of β-adrenergic receptor (β-AA) have been shown to be involved in the development of cardiovascular diseases. Recently, there has been considerable interest in strategies to remove these autoantibodies, particularly therapeutic peptides to neutralize β-AA. Researchers are investigating the roles of cyclic peptides that mimic the structure of relevant epitopes on the β-AR-EC in a number of immune-mediated diseases. Read More

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December 2018

Nerve echogenicity and intranerve CSA variability in high-resolution nerve ultrasound (HRUS) in chronic inflammatory demyelinating polyneuropathy (CIDP).

J Neurol 2018 Dec 15. Epub 2018 Dec 15.

Department of Neurology, Evangelisches Krankenhaus Hattingen, Bredenscheider Str. 54, 45525, Hattingen, Germany.

Objective: HRUS is increasingly being used in the diagnosis and evaluation of autoimmune neuropathies such as CIDP. Recently, studies focused not only on changes of nerves size, but also the fascicular structure and the echogenicity changes in CIDP. However, little is known about the alterations of echogenicity in the long-term course in CIDP. Read More

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December 2018

Contribution of monoaminergic mechanisms to the discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) in Sprague-Dawley rats.

Psychopharmacology (Berl) 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychology, Western Michigan University, Kalamazoo, MI, 49008, USA.

Rationale: 3,4-Methylenedioxypyrovalerone (MDPV) is a popular synthetic cathinone reported to have a high abuse potential. Recent preclinical research indicates the psychopharmacology of MDPV is comparable to cocaine. Despite a recent influx of research on the psychopharmacology of MDPV, few studies have employed preclinical drug discrimination methods to discern the neurochemical mechanisms involved in its interoceptive stimulus effects. Read More

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December 2018

MIG Th1 chemokine in Vitiligo.

Authors:
G Elia

Clin Ter 2018 Nov-Dec;169(6):e303-e307

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

The importance of the Type-1 helper immune response in the development of Vitiligo (Vit), and of chemokine receptor (CXCR)3 receptor and its chemokine monokine induced by interferon (IFN)-γ(MIG) has been shown by several studies. MIG/ interferon (IFN)-γ-inducible protein 10 (IP10) /CXCR3 axis mediated T-cell recruitment into the skin in Vit is an early event in the progression of the disease. MIG and IP10 circulating levels are increased in progressive Vit. Read More

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December 2018
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Italian Translation and Cross-Cultural Adaptation of a Back Pain Screening Questionnaire (Start Back Screening Tool).

Ann Ig 2019 Jan-Feb;31(1):69-75

Research Department, Accademia Italiana di Medicina Osteopatica (AIMO), Saronno, Italy.

Background: Low back pain is a heterogeneous condition, from which most patients recover after a few months. However, a considerable proportion of patients develop chronic pain despite different types of treatment. Primary care evidence-based guidelines for non-specific back pain highlight the importance of identifying indicators of poor prognosis in order for treatment to be appropriately targeted. Read More

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December 2018

Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study.

Med Sci Monit 2018 Dec 16;24:9136-9143. Epub 2018 Dec 16.

Sixth Affiliated Hospital, Kunming Medical University, Yuxi, Yunnan, China (mainland).

BACKGROUND This study aimed to investigate the relationship between serum profiles of prolactin and thyroid stimulating hormone (TSH) and sexual dysfunction in patients with schizophrenia treated with conventional antipsychotic medication. MATERIAL AND METHODS A hospital-based cross-sectional study included 118 patients, age range 18-57 years (55 men, 63 women), with a confirmed diagnosis of schizophrenia. All patients were stable after antipsychotic treatment. Read More

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December 2018

Minimally Invasive Function-Preserving Gastrectomy with Sentinel Node Biopsy for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):14-20. Epub 2018 Dec 14.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Background: Recently, minimally invasive approaches such as endoscopic treatment or laparoscopic gastrectomy for early gastric cancer have made rapid progress. However, the extent of gastrectomy and lymphadenectomy in laparoscopic surgery is radical, similar to that of open gastrectomy for patients with early gastric cancer diagnosed as not indicated for endoscopic treatment. Since it is well known that lymph node metastasis is an important prognostic factor, the standard procedure of gastrectomy with radical lymph node dissection has been performed for the purpose of curative resection. Read More

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December 2018
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