10,408 results match your criteria Deutsches AErzteblatt international[Journal]


Clinical outcomes of the Lotus Valve in patients with bicuspid aortic valve stenosis: An analysis from the RESPOND study.

Catheter Cardiovasc Interv 2019 Feb 17. Epub 2019 Feb 17.

Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, CE, Rotterdam, The Netherlands.

Aims: Patients with bicuspid valves represent a challenging anatomical subgroup for transcatheter aortic valve implantation (TAVI). This analysis evaluated the clinical outcomes of the fully repositionable and retrievable Lotus Valve System in patients with bicuspid aortic valves enrolled in the RESPOND post-market registry.

Methods And Results: The prospective, open-label RESPOND study enrolled 1,014 patients at 41 centers in Europe, New Zealand, and Latin America, 31 (3. Read More

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http://dx.doi.org/10.1002/ccd.28120DOI Listing
February 2019

[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 Feb 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019

Observation of Transverse Λ/Λ[over ¯] Hyperon Polarization in e^{+}e^{-} Annihilation at Belle.

Authors:
Y Guan A Vossen I Adachi K Adamczyk J K Ahn H Aihara S Al Said D M Asner H Atmacan V Aulchenko T Aushev R Ayad V Babu I Badhrees A M Bakich V Bansal P Behera C Beleño M Berger V Bhardwaj B Bhuyan T Bilka J Biswal A Bobrov G Bonvicini A Bozek M Bračko T E Browder L Cao D Červenkov P Chang V Chekelian A Chen B G Cheon K Chilikin K Cho S-K Choi Y Choi D Cinabro S Cunliffe N Dash S Di Carlo J Dingfelder Z Doležal T V Dong Z Drásal S Eidelman D Epifanov J E Fast T Ferber B G Fulsom R Garg V Gaur N Gabyshev A Garmash M Gelb A Giri P Goldenzweig B Golob E Guido J Haba K Hayasaka H Hayashii S Hirose W-S Hou T Iijima K Inami G Inguglia A Ishikawa R Itoh M Iwasaki Y Iwasaki W W Jacobs I Jaegle H B Jeon S Jia Y Jin D Joffe K K Joo T Julius K H Kang T Kawasaki C Kiesling D Y Kim H J Kim J B Kim K T Kim S H Kim K Kinoshita P Kodyš S Korpar D Kotchetkov P Križan R Kroeger P Krokovny T Kuhr R Kulasiri A Kuzmin Y-J Kwon J S Lange I S Lee S C Lee L K Li Y B Li L Li Gioi J Libby D Liventsev M Lubej T Luo M Masuda T Matsuda D Matvienko M Merola H Miyata R Mizuk G B Mohanty H K Moon T Mori R Mussa M Nakao T Nanut K J Nath Z Natkaniec M Nayak M Niiyama N K Nisar S Nishida S Ogawa S Okuno H Ono P Pakhlov G Pakhlova B Pal S Pardi H Park S Paul T K Pedlar R Pestotnik L E Piilonen V Popov E Prencipe A Rabusov A Rostomyan G Russo D Sahoo Y Sakai M Salehi S Sandilya L Santelj T Sanuki V Savinov O Schneider G Schnell C Schwanda R Seidl Y Seino K Senyo O Seon M E Sevior V Shebalin C P Shen T-A Shibata J-G Shiu F Simon A Sokolov E Solovieva M Starič J F Strube M Sumihama T Sumiyoshi W Sutcliffe K Suzuki M Takizawa U Tamponi K Tanida F Tenchini M Uchida T Uglov Y Unno S Uno P Urquijo Y Usov S E Vahsen C Van Hulse R Van Tonder G Varner A Vinokurova V Vorobyev E Waheed B Wang C H Wang M-Z Wang P Wang X L Wang S Watanuki E Widmann E Won H Ye J Yelton J H Yin C Z Yuan Y Yusa Z P Zhang V Zhilich V Zhukova V Zhulanov A Zupanc

Phys Rev Lett 2019 Feb;122(4):042001

J. Stefan Institute, 1000 Ljubljana.

We report the first observation of the spontaneous polarization of Λ and Λ[over ¯] hyperons transverse to the production plane in e^{+}e^{-} annihilation, which is attributed to the effect arising from a polarizing fragmentation function. For inclusive Λ/Λ[over ¯] production, we also report results with subtracted feed-down contributions from Σ^{0} and charm. This measurement uses a dataset of 800. Read More

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https://link.aps.org/doi/10.1103/PhysRevLett.122.042001
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http://dx.doi.org/10.1103/PhysRevLett.122.042001DOI Listing
February 2019
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Passive Ballistic Microbunching of Nonultrarelativistic Electron Bunches Using Electromagnetic Wakefields in Dielectric-Lined Waveguides.

Phys Rev Lett 2019 Feb;122(4):044801

Deutsches Elektronen-Synchrotron, Notkestraße 85, 22607 Hamburg, Germany.

Temporally modulated electron beams have a wide array of applications ranging from the generation of coherently enhanced electromagnetic radiation to the resonant excitation of electromagnetic wakefields in advanced-accelerator concepts. Likewise producing low-energy ultrashort microbunches could be useful for ultrafast electron diffraction and new accelerator-based light-source concepts. In this Letter we propose and experimentally demonstrate a passive microbunching technique capable of forming a picosecond bunch train at ∼6  MeV. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.044801DOI Listing
February 2019

Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention.

Cardiovasc Res 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.

Aim: A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention. Read More

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http://dx.doi.org/10.1093/cvr/cvz015DOI Listing
February 2019

X-ray induced damage of BC-coated bilayer materials under various irradiation conditions.

Sci Rep 2019 Feb 14;9(1):2029. Epub 2019 Feb 14.

Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.

In this report, we analyse X-ray induced damage of BC-coated bilayer materials under various irradiation geometries, following the conditions of our experiment performed at the free-electron-laser facility SACLA. We start with the discussion of structural damage in solids and damage threshold doses for the experimental system components: BC, SiC, Mo and Si. Later, we analyze the irradiation of the experimentally tested coated bilayer systems under two different incidence conditions of a linearly polarized X-ray pulse: (i) grazing incidence, and (ii) normal incidence, in order to compare quantitatively the effect of the pulse incidence on the radiation tolerance of both systems. Read More

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http://dx.doi.org/10.1038/s41598-019-38556-0DOI Listing
February 2019

The European Alpha-1 Research Collaboration (EARCO): a new ERS Clinical Research Collaboration to promote research in alpha-1 antitrypsin deficiency.

Eur Respir J 2019 Feb 14;53(2). Epub 2019 Feb 14.

Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University, Member of the German Centre for Lung Research (DZL), Marburg, Germany.

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http://dx.doi.org/10.1183/13993003.00138-2019DOI Listing
February 2019

Biofouling of membranes in microbial electrochemical technologies: Causes, characterization methods and mitigation strategies.

Bioresour Technol 2019 Feb 2. Epub 2019 Feb 2.

Research Institute on Bioengineering, Membrane Technology and Energetics, University of Pannonia, Egyetem ut 10, 8200 Veszprém, Hungary.

The scope of the review is to discuss the current state of knowledge and lessons learned on biofouling of membrane separators being used for microbial electrochemical technologies (MET). It is illustrated what crucial membrane features have to be considered and how these affect the MET performance, paying particular attention to membrane biofouling. The complexity of the phenomena was demonstrated and thereby, it is shown that membrane qualities related to its surface and inherent material features significantly influence (and can be influenced by) the biofouling process. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.001DOI Listing
February 2019
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Rekonstruktion eines Defektes am proximalen Nasenabhang mittels Procerus-Insellappenplastik.

J Dtsch Dermatol Ges 2019 Feb;17(2):210-213

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Deutschland.

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http://dx.doi.org/10.1111/ddg.13752_gDOI Listing
February 2019

Listen to your physiologist!

Acta Physiol (Oxf) 2019 Feb 14:e13265. Epub 2019 Feb 14.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Aristotle (384-322 B.C.) a Greek philosopher presented in one of his earliest work in the fourth century BC an accurate and universal description of the human cardiovascular system. Read More

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http://dx.doi.org/10.1111/apha.13265DOI Listing
February 2019

Effect of iloprost inhalation on postoperative outcome in high-risk cardiac surgical patients: a prospective randomized-controlled multicentre trial (ILOCARD).

Can J Anaesth 2019 Feb 12. Epub 2019 Feb 12.

Klinik für Anästhesiologie, LMU Klinikum der Universität München, Munich, Germany.

Purpose: Perioperative right ventricular (RV) failure due to pressure overload from pulmonary hypertension (PH) worsens postoperative outcomes after cardiac surgery. Inhaled iloprost is a potent pulmonary vasodilator improving RV performance, ameliorating myocardial and pulmonary ischemia-reperfusion injury and attenuating inflammation. We hypothesized that the prophylactic inhalation of iloprost would reduce postoperative ventilation times after cardiac surgery. Read More

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http://dx.doi.org/10.1007/s12630-019-01309-8DOI Listing
February 2019

Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study.

Strahlenther Onkol 2019 Feb 11. Epub 2019 Feb 11.

Radiation Immuno-Oncology, Center for Translational Cancer Research TUM (TranslaTUM), Einsteinstr. 25, 81675, Munich, Germany.

Background: Membrane heat shock protein 70 (mHsp70) is indicative of high-risk tumors and serves as a tumor-specific target for natural killer (NK) cells stimulated with Hsp70 peptide (TKD) and Interleukin(IL)-2. Radiochemotherapy (RCT), mHsp70-targeting NK cells, and programmed death(PD)-1 inhibition were combined to improve the efficacy of tumor-specific immune cells in a non-small cell lung carcinoma (NSCLC) patient.

Patient: Following simultaneous RCT (64. Read More

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http://link.springer.com/10.1007/s00066-019-01434-9
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http://dx.doi.org/10.1007/s00066-019-01434-9DOI Listing
February 2019
2 Reads

Ensiling fermentation reveals pre-treatment effects for anaerobic digestion of sugarcane biomass: An assessment of ensiling additives on methane potential.

Bioresour Technol 2019 Jan 31. Epub 2019 Jan 31.

Centre for Agricultural Engineering, University of Southern Queensland, Toowoomba, Australia.

Ensiling of sugarcane trash (SCT) and sugarcane stalks (SCS) was studied to assess the effects of molasses (MOL) and lactic acid bacteria (LAB) inoculant on methane potential. The experiment was run for 70 days and monitoring parameters were analyzed at days 0, 5, 15 and 70. Biochemical methane potential (BMP) tests performed with fresh and ensiled material at day 70 showed an increase in methane potential by 24. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.01.143DOI Listing
January 2019

Shedding Light Into Late Saphenous Vein Graft Failure.

Cardiovasc Revasc Med 2019 Jan;20(1):6-8

Deutsches Herzzentrum München, Munich, Germany; Deutsches Zentrum für Herz- und Kreislaufforschung e.V., Berlin, Germany.

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http://dx.doi.org/10.1016/j.carrev.2018.12.008DOI Listing
January 2019

Systematic Generation of Patient-Derived Tumor Models in Pancreatic Cancer.

Cells 2019 Feb 10;8(2). Epub 2019 Feb 10.

Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), 01309 Dresden, Germany.

In highly aggressive malignancies like pancreatic cancer (PC), patient-derived tumor models can serve as disease-relevant models to understand disease-related biology as well as to guide clinical decision-making. In this study, we describe a two-step protocol allowing systematic establishment of patient-derived primary cultures from PC patient tumors. Initial xenotransplantation of surgically resected patient tumors (n = 134) into immunodeficient mice allows for efficient in vivo expansion of vital tumor cells and successful tumor expansion in 38% of patient tumors (51/134). Read More

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http://dx.doi.org/10.3390/cells8020142DOI Listing
February 2019
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A weak topological insulator state in quasi-one-dimensional bismuth iodide.

Nature 2019 Feb 11. Epub 2019 Feb 11.

Institute for Solid State Physics, University of Tokyo, Kashiwa, Japan.

The major breakthroughs in understanding of topological materials over the past decade were all triggered by the discovery of the Z-type topological insulator-a type of material that is insulating in its interior but allows electron flow on its surface. In three dimensions, a topological insulator is classified as either 'strong' or 'weak', and experimental confirmations of the strong topological insulator rapidly followed theoretical predictions. By contrast, the weak topological insulator (WTI) has so far eluded experimental verification, because the topological surface states emerge only on particular side surfaces, which are typically undetectable in real three-dimensional crystals. Read More

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http://dx.doi.org/10.1038/s41586-019-0927-7DOI Listing
February 2019

The influence of microgravity on cerebral blood flow and electrocortical activity.

Exp Brain Res 2019 Feb 11. Epub 2019 Feb 11.

Institute of Movement and Neurosciences, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.

Changes in gravity conditions have previously been reported to influence brain hemodynamics as well as neuronal activity. This paper attempts to identify a possible link between changes in brain blood flow and neuronal activity during microgravity. Middle cerebral artery flow velocity (MCAv) was measured using Doppler ultrasound. Read More

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http://dx.doi.org/10.1007/s00221-019-05490-6DOI Listing
February 2019
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How to prevent inadvertent emergency anticoagulation in acute type A aortic dissection: when in doubt, don't.

Cardiovasc Diagn Ther 2018 Dec;8(6):805-810

Institute for Anesthesiology, Deutsches Herzzentrum Berlin, Berlin, Germany.

Inadvertent emergency anticoagulation in patients with acute type A aortic dissection (ATAAD) has been sparsely reported. There are case reports bringing this potential critical incident to attention, however, little is known about the number of undetected and unreported cases. We approach this issue based on a case report of inadvertent emergency anticoagulation in ATAAD and attempt to shed light on aspects that may have contributed to the critical incident: The challenge of distinguishing an ATAAD from an acute coronary syndrome (ACS) and the potential underestimation of incidents of ATAAD. Read More

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http://dx.doi.org/10.21037/cdt.2018.10.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331368PMC
December 2018
2 Reads

Circulating Pentraxin3-Specific B Cells Are Decreased in Lupus Nephritis.

Front Immunol 2019 25;10:29. Epub 2019 Jan 25.

Unit of Rheumatology, Department of Medicine, University of Padova, Padua, Italy.

Pentraxin3 (PTX3) is overexpressed in kidneys of patients developing lupus nephritis (LN). Active LN is associated with reduced anti-PTX3 antibodies. However, abnormalities of B cell differentiation against PTX3 have not been characterized in systemic lupus erythematosus (SLE). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355680PMC
January 2019
1 Read

Guided de-escalation of DAPT in acute coronary syndrome patients undergoing percutaneous coronary intervention with BVS implantation: a post-hoc analysis from the randomized TROPICAL-ACS trial.

J Thromb Thrombolysis 2019 Feb 9. Epub 2019 Feb 9.

Department of Cardiology, LMU München, Munich, Germany.

To investigate the safety and efficacy of an early platelet function testing (PFT)-guided de-escalation of dual antiplatelet treatment (DAPT) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) with bioresorbable vascular scaffolds (BVS). Early DAPT de-escalation is a new non-inferior alternative to 12-months DAPT in patients with biomarker positive ACS treated with stent implantation. In this post-hoc analysis of the TROPICAL-ACS trial, which randomized 2610 ACS patients to a PFT-guided DAPT de-escalation (switch from prasugrel to clopidogrel) or to control group (uniform prasugrel), we compared clinical outcomes of patients (n = 151) who received a BVS during the index PCI. Read More

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http://dx.doi.org/10.1007/s11239-019-01811-2DOI Listing
February 2019
1 Read

Tunable Plasma-Based Energy Dechirper.

Phys Rev Lett 2019 Jan;122(3):034801

Deutsches Elektronen-Synchrotron DESY, Notkestraße 85, 22607 Hamburg, Germany.

A tunable plasma-based energy dechirper has been developed at FLASHForward to remove the correlated energy spread of a 681 MeV electron bunch. Through the interaction of the bunch with wakefields excited in plasma the projected energy spread was reduced from a FWHM of 1.31% to 0. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.034801DOI Listing
January 2019

Supraglottic airway device use for transoesophageal echocardiography during left atrial appendage occlusion.

Anaesthesia 2019 Mar;74(3):405-406

Deutsches Herzzentrum München, Munich, Germany.

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http://dx.doi.org/10.1111/anae.14597DOI Listing

Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry.

J Heart Lung Transplant 2019 Jan 17. Epub 2019 Jan 17.

James and John Kirklin Institute for Research in Surgical Outcomes (KIRSO), University of Alabama, Birmingham, Alabama.

Background: Despite advances in device technology and treatment strategies, infection remains a major cause of adverse events (AEs) in mechanical circulatory support (MCS) patients. To characterize the epidemiology of MCS infection, we examined the type, location, and timing of infection in the International Society for Heart and Lung Transplantation Registry (ISHLT) for Mechanically Assisted Circulatory Support (IMACS) over 3 years, 2013 to 2015.

Methods: Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) definitions were used to categorize AE infections occurring in MCS patients within IMACS. Read More

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http://dx.doi.org/10.1016/j.healun.2019.01.007DOI Listing
January 2019
1 Read

Non-invasive Hemodynamic CMR Parameters Predicting Maximal Exercise Capacity in 54 Patients with Ebstein's Anomaly.

Pediatr Cardiol 2019 Feb 6. Epub 2019 Feb 6.

Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technical University of Munich, Lazarettstrasse 36, 80636, Munich, Germany.

Background: Exercise capacity is a well-defined marker of outcome in congenital heart disease. We analyzed seventeen cardiovascular magnetic resonance (CMR) derived parameters and their correlation to exercise capacity in patients with Ebstein's anomaly (EA).

Methods: Fifty-four surgery free patients, age 5 to 69 years (median 30 years) prospectively underwent CMR examination and cardiopulmonary exercise testing (CPET). Read More

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http://dx.doi.org/10.1007/s00246-019-02066-7DOI Listing
February 2019
1 Read

[Challenges of primary hip arthroplasty with high hip dislocation].

Orthopade 2019 Feb 6. Epub 2019 Feb 6.

Klinik und Poliklinik für Orthopädie, Unfallchirurgie und Plastische Chirurgie Bereich Endoprothetik/Orthopädie, Universitätsklinik Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Deutschland.

Background: Endoprosthetic care of high hip dislocation is a surgical challenge. The hip anatomy is greatly altered in these patients, including a rather flat and small acetabulum with impaired bone quality and a relevant chance of a bony defect of the acetabular roof. Additionally, the front coverage and in some cases even the dorsal coverage of the hip are missing. Read More

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http://link.springer.com/10.1007/s00132-019-03694-w
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http://dx.doi.org/10.1007/s00132-019-03694-wDOI Listing
February 2019
3 Reads

Risk of atrial fibrillation in big people under the magnifying glass of G. J. Mendel.

Eur Heart J 2019 Feb 5. Epub 2019 Feb 5.

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technical University Munich, Lazarettstr. 36, Munich, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz037DOI Listing
February 2019

Therapeutic potential of menstrual blood-derived endometrial stem cells in cardiac diseases.

Cell Mol Life Sci 2019 Feb 5. Epub 2019 Feb 5.

Institute of Chemistry and Biochemistry, Free University Berlin, 14195, Berlin, Germany.

Despite significant developments in medical and surgical strategies, cardiac diseases remain the leading causes of morbidity and mortality worldwide. Numerous studies involving preclinical and clinical trials have confirmed that stem cell transplantation can help improve cardiac function and regenerate damaged cardiac tissue, and stem cells isolated from bone marrow, heart tissue, adipose tissue and umbilical cord are the primary candidates for transplantation. During the past decade, menstrual blood-derived endometrial stem cells (MenSCs) have gradually become a promising alternative for stem cell-based therapy due to their comprehensive advantages, which include their ability to be periodically and non-invasively collected, their abundant source material, their ability to be regularly donated, their superior proliferative capacity and their ability to be used for autologous transplantation. Read More

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http://dx.doi.org/10.1007/s00018-019-03019-2DOI Listing
February 2019
1 Read

Search for the Higgs Boson Decaying to Two Muons in Proton-Proton Collisions at sqrt[s]=13  TeV.

Authors:
A M Sirunyan A Tumasyan W Adam F Ambrogi E Asilar T Bergauer J Brandstetter E Brondolin M Dragicevic J Erö A Escalante Del Valle M Flechl R Frühwirth V M Ghete J Hrubec M Jeitler N Krammer I Krätschmer D Liko T Madlener I Mikulec N Rad H Rohringer J Schieck R Schöfbeck M Spanring D Spitzbart A Taurok W Waltenberger J Wittmann C-E Wulz M Zarucki V Chekhovsky V Mossolov J Suarez Gonzalez E A De Wolf D Di Croce X Janssen J Lauwers M Pieters M Van De Klundert H Van Haevermaet P Van Mechelen N Van Remortel S Abu Zeid F Blekman J D'Hondt I De Bruyn J De Clercq K Deroover G Flouris D Lontkovskyi S Lowette I Marchesini S Moortgat L Moreels Q Python K Skovpen S Tavernier W Van Doninck P Van Mulders I Van Parijs D Beghin B Bilin H Brun B Clerbaux G De Lentdecker H Delannoy B Dorney G Fasanella L Favart R Goldouzian A Grebenyuk A K Kalsi T Lenzi J Luetic E Starling C Vander Velde P Vanlaer D Vannerom T Cornelis D Dobur A Fagot M Gul I Khvastunov D Poyraz C Roskas D Trocino M Tytgat W Verbeke B Vermassen M Vit N Zaganidis H Bakhshiansohi O Bondu S Brochet G Bruno C Caputo P David C Delaere M Delcourt B Francois A Giammanco G Krintiras V Lemaitre A Magitteri A Mertens M Musich K Piotrzkowski A Saggio M Vidal Marono S Wertz J Zobec F L Alves G A Alves L Brito G Correia Silva C Hensel A Moraes M E Pol P Rebello Teles E Belchior Batista Das Chagas W Carvalho J Chinellato E Coelho E M Da Costa G G Da Silveira D De Jesus Damiao C De Oliveira Martins S Fonseca De Souza H Malbouisson D Matos Figueiredo M Melo De Almeida C Mora Herrera L Mundim H Nogima W L Prado Da Silva L J Sanchez Rosas A Santoro A Sznajder M Thiel E J Tonelli Manganote F Torres Da Silva De Araujo A Vilela Pereira S Ahuja C A Bernardes L Calligaris T R Fernandez Perez Tomei E M Gregores P G Mercadante S F Novaes Sandra S Padula D Romero Abad A Aleksandrov R Hadjiiska P Iaydjiev A Marinov M Misheva M Rodozov M Shopova G Sultanov A Dimitrov L Litov B Pavlov P Petkov W Fang X Gao L Yuan M Ahmad J G Bian G M Chen H S Chen M Chen Y Chen C H Jiang D Leggat H Liao Z Liu F Romeo S M Shaheen A Spiezia J Tao C Wang Z Wang E Yazgan H Zhang J Zhao Y Ban G Chen J Li Q Li S Liu Y Mao S J Qian D Wang Z Xu Y Wang C Avila A Cabrera C A Carrillo Montoya L F Chaparro Sierra C Florez C F González Hernández M A Segura Delgado B Courbon N Godinovic D Lelas I Puljak T Sculac Z Antunovic M Kovac V Brigljevic D Ferencek K Kadija B Mesic A Starodumov T Susa M W Ather A Attikis G Mavromanolakis J Mousa C Nicolaou F Ptochos P A Razis H Rykaczewski M Finger M Finger E Ayala E Carrera Jarrin H Abdalla A A Abdelalim S Khalil S Bhowmik A Carvalho Antunes De Oliveira R K Dewanjee K Ehataht M Kadastik L Perrini M Raidal C Veelken P Eerola H Kirschenmann J Pekkanen M Voutilainen J Havukainen J K Heikkilä T Järvinen V Karimäki R Kinnunen T Lampén K Lassila-Perini S Laurila S Lehti T Lindén P Luukka T Mäenpää H Siikonen E Tuominen J Tuominiemi T Tuuva M Besancon F Couderc M Dejardin D Denegri J L Faure F Ferri S Ganjour A Givernaud P Gras G Hamel de Monchenault P Jarry C Leloup E Locci J Malcles G Negro J Rander A Rosowsky M Ö Sahin M Titov A Abdulsalam C Amendola I Antropov F Beaudette P Busson C Charlot R Granier de Cassagnac I Kucher S Lisniak A Lobanov J Martin Blanco M Nguyen C Ochando G Ortona P Paganini P Pigard R Salerno J B Sauvan Y Sirois A G Stahl Leiton Y Yilmaz A Zabi A Zghiche J-L Agram J Andrea D Bloch J-M Brom E C Chabert V Cherepanov C Collard E Conte J-C Fontaine D Gelé U Goerlach M Jansová A-C Le Bihan N Tonon P Van Hove S Gadrat S Beauceron C Bernet G Boudoul N Chanon R Chierici D Contardo P Depasse H El Mamouni J Fay L Finco S Gascon M Gouzevitch G Grenier B Ille F Lagarde I B Laktineh H Lattaud M Lethuillier L Mirabito A L Pequegnot S Perries A Popov V Sordini M Vander Donckt S Viret S Zhang A Khvedelidze Z Tsamalaidze C Autermann L Feld M K Kiesel K Klein M Lipinski M Preuten M P Rauch C Schomakers J Schulz M Teroerde B Wittmer V Zhukov A Albert D Duchardt M Endres M Erdmann S Erdweg T Esch R Fischer S Ghosh A Güth T Hebbeker C Heidemann K Hoepfner S Knutzen L Mastrolorenzo M Merschmeyer A Meyer P Millet S Mukherjee T Pook M Radziej H Reithler M Rieger F Scheuch A Schmidt D Teyssier S Thüer G Flügge O Hlushchenko B Kargoll T Kress A Künsken T Müller A Nehrkorn A Nowack C Pistone O Pooth H Sert A Stahl M Aldaya Martin T Arndt C Asawatangtrakuldee I Babounikau K Beernaert O Behnke U Behrens A Bermúdez Martínez D Bertsche A A Bin Anuar K Borras V Botta A Campbell P Connor C Contreras-Campana F Costanza V Danilov A De Wit M M Defranchis C Diez Pardos D Domínguez Damiani G Eckerlin T Eichhorn A Elwood E Eren E Gallo A Geiser J M Grados Luyando A Grohsjean P Gunnellini M Guthoff A Harb J Hauk H Jung M Kasemann J Keaveney C Kleinwort J Knolle D Krücker W Lange A Lelek T Lenz K Lipka W Lohmann R Mankel I-A Melzer-Pellmann A B Meyer M Meyer M Missiroli G Mittag J Mnich V Myronenko S K Pflitsch D Pitzl A Raspereza M Savitskyi P Saxena P Schütze C Schwanenberger R Shevchenko A Singh N Stefaniuk H Tholen A Vagnerini G P Van Onsem R Walsh Y Wen K Wichmann C Wissing O Zenaiev R Aggleton S Bein A Benecke V Blobel M Centis Vignali T Dreyer E Garutti D Gonzalez J Haller A Hinzmann M Hoffmann A Karavdina R Klanner R Kogler N Kovalchuk S Kurz V Kutzner J Lange D Marconi J Multhaup M Niedziela D Nowatschin A Perieanu A Reimers O Rieger C Scharf P Schleper S Schumann J Schwandt J Sonneveld H Stadie G Steinbrück F M Stober M Stöver D Troendle E Usai A Vanhoefer B Vormwald M Akbiyik C Barth M Baselga S Baur E Butz R Caspart T Chwalek F Colombo W De Boer A Dierlamm N Faltermann B Freund M Giffels M A Harrendorf F Hartmann S M Heindl U Husemann F Kassel I Katkov S Kudella H Mildner M U Mozer Th Müller M Plagge G Quast K Rabbertz M Schröder I Shvetsov G Sieber H J Simonis R Ulrich S Wayand M Weber T Weiler S Williamson C Wöhrmann R Wolf G Anagnostou G Daskalakis T Geralis A Kyriakis D Loukas G Paspalaki I Topsis-Giotis G Karathanasis S Kesisoglou A Panagiotou N Saoulidou E Tziaferi K Vellidis K Kousouris I Papakrivopoulos Y Tsipolitis I Evangelou C Foudas P Gianneios P Katsoulis P Kokkas S Mallios N Manthos I Papadopoulos E Paradas J Strologas F A Triantis D Tsitsonis M Csanad N Filipovic P Major M I Nagy G Pasztor O Surányi G I Veres G Bencze C Hajdu D Horvath Á Hunyadi F Sikler T Á Vámi V Veszpremi G Vesztergombi N Beni S Czellar J Karancsi A Makovec J Molnar Z Szillasi M Bartók P Raics Z L Trocsanyi B Ujvari S Choudhury J R Komaragiri S Bahinipati P Mal K Mandal A Nayak D K Sahoo S K Swain S Bansal S B Beri V Bhatnagar S Chauhan R Chawla N Dhingra R Gupta A Kaur A Kaur M Kaur S Kaur R Kumar P Kumari M Lohan A Mehta S Sharma J B Singh G Walia A Bhardwaj B C Choudhary R B Garg M Gola S Keshri Ashok Kumar S Malhotra M Naimuddin P Priyanka K Ranjan Aashaq Shah R Sharma R Bhardwaj M Bharti R Bhattacharya S Bhattacharya U Bhawandeep D Bhowmik S Dey S Dutt S Dutta S Ghosh K Mondal S Nandan A Purohit P K Rout A Roy S Roy Chowdhury S Sarkar M Sharan B Singh S Thakur P K Behera R Chudasama D Dutta V Jha V Kumar P K Netrakanti L M Pant P Shukla T Aziz M A Bhat S Dugad B Mahakud S Mitra G B Mohanty N Sur B Sutar Ravindra Kumar Verma S Banerjee S Bhattacharya S Chatterjee P Das M Guchait Sa Jain S Kumar M Maity G Majumder K Mazumdar N Sahoo T Sarkar S Chauhan S Dube V Hegde A Kapoor K Kothekar S Pandey A Rane S Sharma S Chenarani E Eskandari Tadavani S M Etesami M Khakzad M Mohammadi Najafabadi M Naseri F Rezaei Hosseinabadi B Safarzadeh M Zeinali M Felcini M Grunewald M Abbrescia C Calabria A Colaleo D Creanza L Cristella N De Filippis M De Palma A Di Florio F Errico L Fiore A Gelmi G Iaselli S Lezki G Maggi M Maggi G Miniello S My S Nuzzo A Pompili G Pugliese R Radogna A Ranieri G Selvaggi A Sharma L Silvestris R Venditti P Verwilligen G Zito G Abbiendi C Battilana D Bonacorsi L Borgonovi S Braibant-Giacomelli L Brigliadori R Campanini P Capiluppi A Castro F R Cavallo S S Chhibra G Codispoti M Cuffiani G M Dallavalle F Fabbri A Fanfani P Giacomelli C Grandi L Guiducci S Marcellini G Masetti A Montanari F L Navarria A Perrotta A M Rossi T Rovelli G P Siroli N Tosi S Albergo A Di Mattia R Potenza A Tricomi C Tuve G Barbagli K Chatterjee V Ciulli C Civinini R D'Alessandro E Focardi G Latino P Lenzi M Meschini S Paoletti L Russo G Sguazzoni D Strom L Viliani L Benussi S Bianco F Fabbri D Piccolo F Primavera F Ferro F Ravera E Robutti S Tosi A Benaglia A Beschi L Brianza F Brivio V Ciriolo M E Dinardo S Fiorendi S Gennai A Ghezzi P Govoni M Malberti S Malvezzi R A Manzoni D Menasce L Moroni M Paganoni D Pedrini S Pigazzini S Ragazzi T Tabarelli de Fatis S Buontempo N Cavallo A Di Crescenzo S Di Guida F Fabozzi F Fienga G Galati A O M Iorio W A Khan L Lista S Meola P Paolucci C Sciacca E Voevodina P Azzi N Bacchetta L Benato D Bisello A Boletti A Bragagnolo R Carlin P Checchia M Dall'Osso P De Castro Manzano T Dorigo U Dosselli F Gasparini U Gasparini A Gozzelino S Lacaprara P Lujan M Margoni A T Meneguzzo N Pozzobon P Ronchese R Rossin F Simonetto A Tiko E Torassa S Ventura M Zanetti A Braghieri A Magnani P Montagna S P Ratti V Re M Ressegotti C Riccardi P Salvini I Vai P Vitulo L Alunni Solestizi M Biasini G M Bilei C Cecchi D Ciangottini L Fanò P Lariccia E Manoni G Mantovani V Mariani M Menichelli A Rossi A Santocchia D Spiga K Androsov P Azzurri G Bagliesi L Bianchini T Boccali L Borrello R Castaldi M A Ciocci R Dell'Orso G Fedi L Giannini A Giassi M T Grippo F Ligabue E Manca G Mandorli A Messineo F Palla A Rizzi P Spagnolo R Tenchini G Tonelli A Venturi P G Verdini L Barone F Cavallari M Cipriani N Daci D Del Re E Di Marco M Diemoz S Gelli E Longo B Marzocchi P Meridiani G Organtini F Pandolfi R Paramatti F Preiato S Rahatlou C Rovelli F Santanastasio N Amapane R Arcidiacono S Argiro M Arneodo N Bartosik R Bellan C Biino N Cartiglia F Cenna M Costa R Covarelli N Demaria B Kiani C Mariotti S Maselli E Migliore V Monaco E Monteil M Monteno M M Obertino L Pacher N Pastrone M Pelliccioni G L Pinna Angioni A Romero M Ruspa R Sacchi K Shchelina V Sola A Solano A Staiano S Belforte V Candelise M Casarsa F Cossutti G Della Ricca F Vazzoler A Zanetti D H Kim G N Kim M S Kim J Lee S Lee S W Lee C S Moon Y D Oh S Sekmen D C Son Y C Yang H Kim D H Moon G Oh J Goh T J Kim S Cho S Choi Y Go D Gyun S Ha B Hong Y Jo K Lee K S Lee S Lee J Lim S K Park Y Roh H Kim J Almond J Kim J S Kim H Lee K Lee K Nam S B Oh B C Radburn-Smith S H Seo U K Yang H D Yoo G B Yu H Kim J H Kim J S H Lee I C Park Y Choi C Hwang J Lee I Yu V Dudenas A Juodagalvis J Vaitkus I Ahmed Z A Ibrahim M A B Md Ali F Mohamad Idris W A T Wan Abdullah M N Yusli Z Zolkapli H Castilla-Valdez E De La Cruz-Burelo M C Duran-Osuna I Heredia-De La Cruz R Lopez-Fernandez J Mejia Guisao R I Rabadan-Trejo G Ramirez-Sanchez R Reyes-Almanza A Sanchez-Hernandez S Carrillo Moreno C Oropeza Barrera F Vazquez Valencia J Eysermans I Pedraza H A Salazar Ibarguen C Uribe Estrada A Morelos Pineda D Krofcheck S Bheesette P H Butler A Ahmad M Ahmad M I Asghar Q Hassan H R Hoorani A Saddique M A Shah M Shoaib M Waqas H Bialkowska M Bluj B Boimska T Frueboes M Górski M Kazana K Nawrocki M Szleper P Traczyk P Zalewski K Bunkowski A Byszuk K Doroba A Kalinowski M Konecki J Krolikowski M Misiura M Olszewski A Pyskir M Walczak P Bargassa C Beirão Da Cruz E Silva A Di Francesco P Faccioli B Galinhas M Gallinaro J Hollar N Leonardo L Lloret Iglesias M V Nemallapudi J Seixas G Strong O Toldaiev D Vadruccio J Varela V Alexakhin A Golunov I Golutvin N Gorbounov I Gorbunov A Kamenev V Karjavin A Lanev A Malakhov V Matveev P Moisenz V Palichik V Perelygin M Savina S Shmatov S Shulha N Skatchkov V Smirnov A Zarubin V Golovtsov Y Ivanov V Kim E Kuznetsova P Levchenko V Murzin V Oreshkin I Smirnov D Sosnov V Sulimov L Uvarov S Vavilov A Vorobyev Yu Andreev A Dermenev S Gninenko N Golubev A Karneyeu M Kirsanov N Krasnikov A Pashenkov D Tlisov A Toropin V Epshteyn V Gavrilov N Lychkovskaya V Popov I Pozdnyakov G Safronov A Spiridonov A Stepennov V Stolin M Toms E Vlasov A Zhokin T Aushev A Bylinkin R Chistov M Danilov P Parygin D Philippov S Polikarpov E Tarkovskii V Andreev M Azarkin I Dremin M Kirakosyan S V Rusakov A Terkulov A Baskakov A Belyaev E Boos V Bunichev M Dubinin L Dudko A Ershov A Gribushin V Klyukhin O Kodolova I Lokhtin I Miagkov S Obraztsov S Petrushanko V Savrin V Blinov T Dimova L Kardapoltsev D Shtol Y Skovpen I Azhgirey I Bayshev S Bitioukov D Elumakhov A Godizov V Kachanov A Kalinin D Konstantinov P Mandrik V Petrov R Ryutin S Slabospitskii A Sobol S Troshin N Tyurin A Uzunian A Volkov A Babaev P Adzic P Cirkovic D Devetak M Dordevic J Milosevic J Alcaraz Maestre A Álvarez Fernández I Bachiller M Barrio Luna J A Brochero Cifuentes M Cerrada N Colino B De La Cruz A Delgado Peris C Fernandez Bedoya J P Fernández Ramos J Flix M C Fouz O Gonzalez Lopez S Goy Lopez J M Hernandez M I Josa D Moran A Pérez-Calero Yzquierdo J Puerta Pelayo I Redondo L Romero M S Soares A Triossi C Albajar J F de Trocóniz J Cuevas C Erice J Fernandez Menendez S Folgueras I Gonzalez Caballero J R González Fernández E Palencia Cortezon S Sanchez Cruz P Vischia J M Vizan Garcia I J Cabrillo A Calderon B Chazin Quero J Duarte Campderros M Fernandez P J Fernández Manteca A García Alonso J Garcia-Ferrero G Gomez A Lopez Virto J Marco C Martinez Rivero P Martinez Ruiz Del Arbol F Matorras J Piedra Gomez C Prieels T Rodrigo A Ruiz-Jimeno L Scodellaro N Trevisani I Vila R Vilar Cortabitarte D Abbaneo B Akgun E Auffray P Baillon A H Ball D Barney J Bendavid M Bianco A Bocci C Botta T Camporesi M Cepeda G Cerminara E Chapon Y Chen G Cucciati D d'Enterria A Dabrowski V Daponte A David A De Roeck N Deelen M Dobson T du Pree M Dünser N Dupont A Elliott-Peisert P Everaerts F Fallavollita G Franzoni J Fulcher W Funk D Gigi A Gilbert K Gill F Glege D Gulhan J Hegeman V Innocente A Jafari P Janot O Karacheban J Kieseler V Knünz A Kornmayer M Krammer C Lange P Lecoq C Lourenço M T Lucchini L Malgeri M Mannelli F Meijers J A Merlin S Mersi E Meschi P Milenovic F Moortgat M Mulders H Neugebauer J Ngadiuba S Orfanelli L Orsini F Pantaleo L Pape E Perez M Peruzzi A Petrilli G Petrucciani A Pfeiffer M Pierini F M Pitters D Rabady A Racz T Reis G Rolandi M Rovere H Sakulin C Schäfer C Schwick M Seidel M Selvaggi A Sharma P Silva P Sphicas A Stakia J Steggemann M Tosi D Treille A Tsirou V Veckalns M Verweij W D Zeuner W Bertl L Caminada K Deiters W Erdmann R Horisberger Q Ingram H C Kaestli D Kotlinski U Langenegger T Rohe S A Wiederkehr M Backhaus L Bäni P Berger B Casal N Chernyavskaya G Dissertori M Dittmar M Donegà C Dorfer C Grab C Heidegger D Hits J Hoss T Klijnsma W Lustermann M Marionneau M T Meinhard D Meister F Micheli P Musella F Nessi-Tedaldi J Pata F Pauss G Perrin L Perrozzi M Quittnat M Reichmann D Ruini D A Sanz Becerra M Schönenberger L Shchutska V R Tavolaro K Theofilatos M L Vesterbacka Olsson R Wallny D H Zhu T K Aarrestad C Amsler D Brzhechko M F Canelli A De Cosa R Del Burgo S Donato C Galloni T Hreus B Kilminster I Neutelings D Pinna G Rauco P Robmann D Salerno K Schweiger C Seitz Y Takahashi A Zucchetta Y H Chang K Y Cheng T H Doan Sh Jain R Khurana C M Kuo W Lin A Pozdnyakov S S Yu P Chang Y Chao K F Chen P H Chen W-S Hou Arun Kumar R-S Lu E Paganis A Psallidas A Steen J F Tsai B Asavapibhop N Srimanobhas N Suwonjandee A Bat F Boran S Cerci S Damarseckin Z S Demiroglu C Dozen I Dumanoglu S Girgis G Gokbulut Y Guler E Gurpinar I Hos E E Kangal O Kara A Kayis Topaksu U Kiminsu M Oglakci G Onengut K Ozdemir S Ozturk D Sunar Cerci B Tali U G Tok S Turkcapar I S Zorbakir C Zorbilmez B Isildak G Karapinar M Yalvac M Zeyrek I O Atakisi E Gülmez M Kaya O Kaya S Ozkorucuklu S Tekten E A Yetkin M N Agaras S Atay A Cakir K Cankocak Y Komurcu S Sen B Grynyov L Levchuk T Alexander F Ball L Beck J J Brooke D Burns E Clement D Cussans O Davignon H Flacher J Goldstein G P Heath H F Heath L Kreczko D M Newbold S Paramesvaran B Penning T Sakuma D Smith V J Smith J Taylor K W Bell A Belyaev C Brew R M Brown D Cieri D J A Cockerill J A Coughlan K Harder S Harper J Linacre E Olaiya D Petyt C H Shepherd-Themistocleous A Thea I R Tomalin T Williams W J Womersley G Auzinger R Bainbridge P Bloch J Borg S Breeze O Buchmuller A Bundock S Casasso D Colling L Corpe P Dauncey G Davies M Della Negra R Di Maria Y Haddad G Hall G Iles T James M Komm C Laner L Lyons A-M Magnan S Malik A Martelli J Nash A Nikitenko V Palladino M Pesaresi A Richards A Rose E Scott C Seez A Shtipliyski G Singh M Stoye T Strebler S Summers A Tapper K Uchida T Virdee N Wardle D Winterbottom J Wright S C Zenz J E Cole P R Hobson A Khan P Kyberd C K Mackay A Morton I D Reid L Teodorescu S Zahid A Borzou K Call J Dittmann K Hatakeyama H Liu C Madrid B Mcmaster N Pastika C Smith R Bartek A Dominguez A Buccilli S I Cooper C Henderson P Rumerio C West D Arcaro T Bose D Gastler D Rankin C Richardson J Rohlf L Sulak D Zou G Benelli X Coubez D Cutts M Hadley J Hakala U Heintz J M Hogan K H M Kwok E Laird G Landsberg J Lee Z Mao M Narain J Pazzini S Piperov S Sagir R Syarif D Yu R Band C Brainerd R Breedon D Burns M Calderon De La Barca Sanchez M Chertok J Conway R Conway P T Cox R Erbacher C Flores G Funk W Ko O Kukral R Lander C Mclean M Mulhearn D Pellett J Pilot S Shalhout M Shi D Stolp D Taylor K Tos M Tripathi Z Wang F Zhang M Bachtis C Bravo R Cousins A Dasgupta A Florent J Hauser M Ignatenko N Mccoll S Regnard D Saltzberg C Schnaible V Valuev E Bouvier K Burt R Clare J W Gary S M A Ghiasi Shirazi G Hanson G Karapostoli E Kennedy F Lacroix O R Long M Olmedo Negrete M I Paneva W Si L Wang H Wei S Wimpenny B R Yates J G Branson S Cittolin M Derdzinski R Gerosa D Gilbert B Hashemi A Holzner D Klein G Kole V Krutelyov J Letts M Masciovecchio D Olivito S Padhi M Pieri M Sani V Sharma S Simon M Tadel A Vartak S Wasserbaech J Wood F Würthwein A Yagil G Zevi Della Porta N Amin R Bhandari J Bradmiller-Feld C Campagnari M Citron A Dishaw V Dutta M Franco Sevilla L Gouskos R Heller J Incandela A Ovcharova H Qu J Richman D Stuart I Suarez S Wang J Yoo D Anderson A Bornheim J Bunn J M Lawhorn H B Newman T Q Nguyen M Spiropulu J R Vlimant R Wilkinson S Xie Z Zhang R Y Zhu M B Andrews T Ferguson T Mudholkar M Paulini M Sun I Vorobiev M Weinberg J P Cumalat W T Ford F Jensen A Johnson M Krohn S Leontsinis E MacDonald T Mulholland K Stenson K A Ulmer S R Wagner J Alexander J Chaves Y Cheng J Chu A Datta K Mcdermott N Mirman J R Patterson D Quach A Rinkevicius A Ryd L Skinnari L Soffi S M Tan Z Tao J Thom J Tucker P Wittich M Zientek S Abdullin M Albrow M Alyari G Apollinari A Apresyan A Apyan S Banerjee L A T Bauerdick A Beretvas J Berryhill P C Bhat G Bolla K Burkett J N Butler A Canepa G B Cerati H W K Cheung F Chlebana M Cremonesi J Duarte V D Elvira J Freeman Z Gecse E Gottschalk L Gray D Green S Grünendahl O Gutsche J Hanlon R M Harris S Hasegawa J Hirschauer Z Hu B Jayatilaka S Jindariani M Johnson U Joshi B Klima M J Kortelainen B Kreis S Lammel D Lincoln R Lipton M Liu T Liu J Lykken K Maeshima N Magini J M Marraffino D Mason P McBride P Merkel S Mrenna S Nahn V O'Dell K Pedro C Pena O Prokofyev G Rakness L Ristori A Savoy-Navarro B Schneider E Sexton-Kennedy A Soha W J Spalding L Spiegel S Stoynev J Strait N Strobbe L Taylor S Tkaczyk N V Tran L Uplegger E W Vaandering C Vernieri M Verzocchi R Vidal M Wang H A Weber A Whitbeck D Acosta P Avery P Bortignon D Bourilkov A Brinkerhoff L Cadamuro A Carnes M Carver D Curry R D Field S V Gleyzer B M Joshi J Konigsberg A Korytov P Ma K Matchev H Mei G Mitselmakher K Shi D Sperka L Thomas J Wang S Wang Y R Joshi S Linn A Ackert T Adams A Askew S Hagopian V Hagopian K F Johnson T Kolberg G Martinez T Perry H Prosper A Saha A Santra V Sharma R Yohay M M Baarmand V Bhopatkar S Colafranceschi M Hohlmann D Noonan T Roy F Yumiceva M R Adams L Apanasevich D Berry R R Betts R Cavanaugh X Chen S Dittmer O Evdokimov C E Gerber D A Hangal D J Hofman K Jung J Kamin C Mills I D Sandoval Gonzalez M B Tonjes N Varelas H Wang Z Wu J Zhang M Alhusseini B Bilki W Clarida K Dilsiz S Durgut R P Gandrajula M Haytmyradov V Khristenko J-P Merlo A Mestvirishvili A Moeller J Nachtman H Ogul Y Onel F Ozok A Penzo C Snyder E Tiras J Wetzel B Blumenfeld A Cocoros N Eminizer D Fehling L Feng A V Gritsan W T Hung P Maksimovic J Roskes U Sarica M Swartz M Xiao C You A Al-Bataineh P Baringer A Bean S Boren J Bowen J Castle S Khalil A Kropivnitskaya D Majumder W Mcbrayer M Murray C Rogan S Sanders E Schmitz J D Tapia Takaki Q Wang A Ivanov K Kaadze Y Maravin A Modak A Mohammadi L K Saini N Skhirtladze F Rebassoo D Wright A Baden O Baron A Belloni S C Eno Y Feng C Ferraioli N J Hadley S Jabeen G Y Jeng R G Kellogg J Kunkle A C Mignerey F Ricci-Tam Y H Shin A Skuja S C Tonwar K Wong D Abercrombie B Allen V Azzolini R Barbieri A Baty G Bauer R Bi S Brandt W Busza I A Cali M D'Alfonso Z Demiragli G Gomez Ceballos M Goncharov P Harris D Hsu M Hu Y Iiyama G M Innocenti M Klute D Kovalskyi Y-J Lee A Levin P D Luckey B Maier A C Marini C Mcginn C Mironov S Narayanan X Niu C Paus C Roland G Roland G S F Stephans K Sumorok K Tatar D Velicanu J Wang T W Wang B Wyslouch S Zhaozhong A C Benvenuti R M Chatterjee A Evans P Hansen S Kalafut Y Kubota Z Lesko J Mans S Nourbakhsh N Ruckstuhl R Rusack J Turkewitz M A Wadud J G Acosta S Oliveros E Avdeeva K Bloom D R Claes C Fangmeier F Golf R Gonzalez Suarez R Kamalieddin I Kravchenko J Monroy J E Siado G R Snow B Stieger A Godshalk C Harrington I Iashvili A Kharchilava D Nguyen A Parker S Rappoccio B Roozbahani G Alverson E Barberis C Freer A Hortiangtham A Massironi D M Morse T Orimoto R Teixeira De Lima T Wamorkar B Wang A Wisecarver D Wood S Bhattacharya O Charaf K A Hahn N Mucia N Odell M H Schmitt K Sung M Trovato M Velasco R Bucci N Dev M Hildreth K Hurtado Anampa C Jessop D J Karmgard N Kellams K Lannon W Li N Loukas N Marinelli F Meng C Mueller Y Musienko M Planer A Reinsvold R Ruchti P Siddireddy G Smith S Taroni M Wayne A Wightman M Wolf A Woodard J Alimena L Antonelli B Bylsma L S Durkin S Flowers B Francis A Hart C Hill W Ji T Y Ling W Luo B L Winer H W Wulsin S Cooperstein P Elmer J Hardenbrook P Hebda S Higginbotham A Kalogeropoulos D Lange J Luo D Marlow K Mei I Ojalvo J Olsen C Palmer P Piroué J Salfeld-Nebgen D Stickland C Tully S Malik S Norberg A Barker V E Barnes S Das L Gutay M Jones A W Jung A Khatiwada D H Miller N Neumeister C C Peng H Qiu J F Schulte J Sun F Wang R Xiao W Xie T Cheng J Dolen N Parashar Z Chen K M Ecklund S Freed F J M Geurts M Guilbaud M Kilpatrick W Li B Michlin B P Padley J Roberts J Rorie W Shi Z Tu J Zabel A Zhang A Bodek P de Barbaro R Demina Y T Duh J L Dulemba C Fallon T Ferbel M Galanti A Garcia-Bellido J Han O Hindrichs A Khukhunaishvili K H Lo P Tan R Taus M Verzetti A Agapitos J P Chou Y Gershtein T A Gómez Espinosa E Halkiadakis M Heindl E Hughes S Kaplan R Kunnawalkam Elayavalli S Kyriacou A Lath R Montalvo K Nash M Osherson H Saka S Salur S Schnetzer D Sheffield S Somalwar R Stone S Thomas P Thomassen M Walker A G Delannoy J Heideman G Riley K Rose S Spanier K Thapa O Bouhali A Castaneda Hernandez A Celik M Dalchenko M De Mattia A Delgado S Dildick R Eusebi J Gilmore T Huang T Kamon R Mueller Y Pakhotin R Patel A Perloff L Perniè D Rathjens A Safonov A Tatarinov N Akchurin J Damgov F De Guio P R Dudero J Faulkner S Kunori K Lamichhane S W Lee T Mengke S Muthumuni T Peltola S Undleeb I Volobouev Z Wang S Greene A Gurrola R Janjam W Johns C Maguire A Melo H Ni K Padeken J D Ruiz Alvarez P Sheldon S Tuo J Velkovska Q Xu M W Arenton P Barria B Cox R Hirosky M Joyce A Ledovskoy H Li C Neu T Sinthuprasith Y Wang E Wolfe F Xia R Harr P E Karchin N Poudyal J Sturdy P Thapa S Zaleski M Brodski J Buchanan C Caillol D Carlsmith S Dasu L Dodd S Duric B Gomber M Grothe M Herndon A Hervé U Hussain P Klabbers A Lanaro A Levine K Long R Loveless T Ruggles A Savin N Smith W H Smith N Woods

Phys Rev Lett 2019 Jan;122(2):021801

University of Wisconsin-Madison, Madison, Wisconsin, USA.

A search for the Higgs boson decaying to two oppositely charged muons is presented using data recorded by the CMS experiment at the CERN LHC in 2016 at a center-of-mass energy sqrt[s]=13  TeV, corresponding to an integrated luminosity of 35.9  fb^{-1}. Data are found to be compatible with the predicted background. Read More

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https://link.aps.org/doi/10.1103/PhysRevLett.122.021801
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http://dx.doi.org/10.1103/PhysRevLett.122.021801DOI Listing
January 2019
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7.512 Impact Factor

Angiographic and clinical outcomes of STEMI patients treated with bioresorbable or metallic everolimus-eluting stents. A pooled analysis of individual patient data from 2 randomized trials.

EuroIntervention 2019 Feb 5. Epub 2019 Feb 5.

Deutsches Herzzentrum Munchen, Technische Universität München, Munich, Germany.

Aims: Bioresorbable scaffolds (BRS) were conceived to ensure transient coronary artery support during antiproliferative drug delivery. However, the everolimus-eluting bioresorbable scaffold Absorb (Abbott Vascular, Santa Clara, CA, USA) was found inferior to everolimus-eluting metallic stents (EES) in moderately complex coronary anatomies. We sought to investigate whether the Absorb represents a valuable option for the percutaneous treatment of patients with ST-elevation myocardial infarction (STEMI). Read More

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http://dx.doi.org/10.4244/EIJ-D-18-01080DOI Listing
February 2019

Revisiting the old and learning the new of zinc in immunity.

Nat Immunol 2019 Feb 4. Epub 2019 Feb 4.

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan.

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http://dx.doi.org/10.1038/s41590-019-0319-zDOI Listing
February 2019

Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention.

Sci Rep 2019 Feb 4;9(1):1303. Epub 2019 Feb 4.

Department of Internal Medicine IV, University Hospital of Tübingen, Tübingen, Germany.

Niacin inhibits fatty acid flux from adipose tissue to liver, reduces hepatic triglyceride synthesis and increases hepatic lipid oxidation. Thus, niacin may have a role in the regulation of liver fat content in humans. We tested if dietary intake of niacin predicts change of liver fat content during a lifestyle intervention. Read More

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http://dx.doi.org/10.1038/s41598-018-38002-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362104PMC
February 2019

Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.

Transl Psychiatry 2019 Feb 4;9(1):75. Epub 2019 Feb 4.

Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Preclinical studies point to a pivotal role of the orexin 1 (OX) receptor in arousal and fear learning and therefore suggest the HCRTR1 gene as a prime candidate in panic disorder (PD) with/without agoraphobia (AG), PD/AG treatment response, and PD/AG-related intermediate phenotypes. Here, a multilevel approach was applied to test the non-synonymous HCRTR1 C/T Ile408Val gene variant (rs2271933) for association with PD/AG in two independent case-control samples (total n = 613 cases, 1839 healthy subjects), as an outcome predictor of a six-weeks exposure-based cognitive behavioral therapy (CBT) in PD/AG patients (n = 189), as well as with respect to agoraphobic cognitions (ACQ) (n = 483 patients, n = 2382 healthy subjects), fMRI alerting network activation in healthy subjects (n = 94), and a behavioral avoidance task in PD/AG pre- and post-CBT (n = 271). The HCRTR1 rs2271933 T allele was associated with PD/AG in both samples independently, and in their meta-analysis (p = 4. Read More

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http://dx.doi.org/10.1038/s41398-019-0415-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361931PMC
February 2019
2 Reads

Design-functionality relationships for adhesion/growth-regulatory galectins.

Proc Natl Acad Sci U S A 2019 Feb 4. Epub 2019 Feb 4.

Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323;

Glycan-lectin recognition is assumed to elicit its broad range of (patho)physiological functions via a combination of specific contact formation with generation of complexes of distinct signal-triggering topology on biomembranes. Faced with the challenge to understand why evolution has led to three particular modes of modular architecture for adhesion/growth-regulatory galectins in vertebrates, here we introduce protein engineering to enable design switches. The impact of changes is measured in assays on cell growth and on bridging fully synthetic nanovesicles (glycodendrimersomes) with a chemically programmable surface. Read More

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http://dx.doi.org/10.1073/pnas.1813515116DOI Listing
February 2019

Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome.

Life Sci Alliance 2019 Feb 4;2(1). Epub 2019 Feb 4.

Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany

RecQ-like helicase 4 (RECQL4) is mutated in patients suffering from the Rothmund-Thomson syndrome, a genetic disease characterized by premature aging, skeletal malformations, and high cancer susceptibility. Known roles of RECQL4 in DNA replication and repair provide a possible explanation of chromosome instability observed in patient cells. Here, we demonstrate that RECQL4 is a microtubule-associated protein (MAP) localizing to the mitotic spindle. Read More

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http://dx.doi.org/10.26508/lsa.201800120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362308PMC
February 2019
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Modulators of Transient Receptor Potential (TRP) Channels as Therapeutic Options in Lung Disease.

Pharmaceuticals (Basel) 2019 Feb 1;12(1). Epub 2019 Feb 1.

Walther-Straub-Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research(DZL), LMU Munich, Nussbaumstr. 26, D-80336 Munich, Germany.

The lungs are essential for gas exchange and serve as the gateways of our body to the external environment. They are easily accessible for drugs from both sides, the airways and the vasculature. Recent literature provides evidence for a role of Transient Receptor Potential (TRP) channels as chemosensors and essential members of signal transduction cascades in stress-induced cellular responses. Read More

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http://dx.doi.org/10.3390/ph12010023DOI Listing
February 2019
1 Read

[Epidemiology of severe visual impairment and blindness of old people in Germany].

Ophthalmologe 2019 Feb;116(2):201-212

Universitäts-Augenklinik, Universität Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.

Approximately 500,000 blind and 1 million visually impaired persons live in Germany, which lacks a national blind registry. Therefore data from social welfare agencies and population-based studies are used to estimate prevalence and incidence. Main causes for severe visual impairment and blindness are age-related macular degeneration, glaucoma and diabetic eye diseases. Read More

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http://dx.doi.org/10.1007/s00347-019-0853-yDOI Listing
February 2019

Workforce requirements in rheumatology: a systematic literature review informing the development of a workforce prediction risk of bias tool and the EULAR points to consider.

RMD Open 2018 5;4(2):e000756. Epub 2018 Dec 5.

Department of Rheumatology, Leiden University Medical Centre, Leiden, and Zuyderland Medical Center, Heerlen, The Netherlands.

Objective: To summarise the available information on physician workforce modelling, to develop a rheumatology workforce prediction risk of bias tool and to apply it to existing studies in rheumatology.

Methods: A systematic literature review (SLR) was performed in key electronic databases (1946-2017) comprising an update of an SLR in rheumatology and a hierarchical SLR in other medical fields. Data on the type of workforce prediction models and the factors considered in the models were extracted. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336097PMC
December 2018

EULAR 'points to consider' for the conduction of workforce requirement studies in rheumatology.

RMD Open 2018 5;4(2):e000780. Epub 2018 Dec 5.

Department of Rheumatology and Clinical Immunology, Charitè University Hospital, Berlin, Germany.

Objective: Current methods used for forecasting workforce requirements in rheumatology are disparate, as are the parameters incorporated into workforce projection studies. The objective of these European League Against Rheumatism (EULAR points to consider (PTC) is to guide future workforce studies in adult rheumatology in order to produce valid and reliable manpower estimates.

Methods: The EULAR Standardised Operating Procedures were followed. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336096PMC
December 2018
3 Reads

An overview of methods for deriving the radiative transfer theory from the Maxwell equations. II: Approach based on the Dyson and Bethe-Salpeter equations.

J Quant Spectrosc Radiat Transf 2019 Feb 23;224:25-36. Epub 2018 Oct 23.

NASA Goddard Institute for Space Studies, 2880 Broadway, New York, NY 10025, USA.

In this paper, the vector radiative transfer equation is derived by means of the vector integral Foldy equations describing the electromagnetic scattering by a group of particles. By Assuming that in a discrete random medium the positions of the particles are statistically independent and by applying the Twersky approximation to the order-of-scattering expansion of the total field, we derive the Dyson equation for the coherent field and the ladder approximated Bethe-Salpeter equation for the dyadic correlation function. Then, under the far-field assumption for sparsely distributed particles, the Dyson equation is reduced to the Foldy integral equation for the coherent field, while the iterated solution of the Bethe-Salpeter equation ultimately yields the vector radiative transfer equation. Read More

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http://dx.doi.org/10.1016/j.jqsrt.2018.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350797PMC
February 2019

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2018.

Ann Rheum Dis 2019 Feb 2. Epub 2019 Feb 2.

Swedish Medical Center, University of Washington, Seattle, Washington, USA.

To develop a comprehensive listing of the greatest unmet scientific and clinical needs in rheumatology. The 20th annual international Targeted Therapies meeting brought more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of five disease-specific groups with 20-30 experts assigned to each group based on expertise. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214280DOI Listing
February 2019
5 Reads

A SEPT1-based scaffold is required for Golgi integrity and function.

J Cell Sci 2019 Feb 1;132(3). Epub 2019 Feb 1.

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Berlin, Molecular Pharmacology and Cell Biology, 13125 Berlin, Germany

Compartmentalization of membrane transport and signaling processes is of pivotal importance to eukaryotic cell function. While plasma membrane compartmentalization and dynamics are well known to depend on the scaffolding function of septin GTPases, the roles of septins at intracellular membranes have remained largely elusive. Here, we show that the structural and functional integrity of the Golgi depends on its association with a septin 1 (SEPT1)-based scaffold, which promotes local microtubule nucleation and positioning of the Golgi. Read More

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http://dx.doi.org/10.1242/jcs.225557DOI Listing
February 2019

Effects of Congenital Heart Disease Treatmenton Quality of Life.

Am J Cardiol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technical University of Munich, Munich, Germany. Electronic address:

With rising survival rates of patients with congenital heart disease (CHD), functional health variables have become the key aspect in treatment evaluation. The effectiveness of various treatment options on the health-related quality of life (HRQoL) and the objectively measured exercise capacity as peak oxygen uptake (VO peak) remains rather unclear and hence, its investigation is the primary aim of this study. Data from 1014 patients (≥14-years-old, various CHD) were retrospectively reviewed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149193005
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http://dx.doi.org/10.1016/j.amjcard.2018.12.048DOI Listing
January 2019
2 Reads

InTAD: chromosome conformation guided analysis of enhancer target genes.

BMC Bioinformatics 2019 Jan 31;20(1):60. Epub 2019 Jan 31.

Department of Medicine, Division of Medical Genetics, University of California San Diego (UCSD), San Diego, USA.

Background: High-throughput technologies for analyzing chromosome conformation at a genome scale have revealed that chromatin is organized in topologically associated domains (TADs). While TADs are relatively stable across cell types, intra-TAD activities are cell type specific. Epigenetic profiling of different tissues and cell-types has identified a large number of non-coding epigenetic regulatory elements ('enhancers') that can be located far away from coding genes. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-019-2655-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357397PMC
January 2019
1 Read

[The Diabetic Heart and Heart Failure - Update on Mechanisms and Therapy].

Dtsch Med Wochenschr 2019 Feb 31;144(3):175-179. Epub 2019 Jan 31.

Institut für klinische Diabetologie, Deutsches Diabetes-Zentrum, Leibniz Zentrum für Diabetes Forschung, Heinrich-Heine-Universität, Düsseldorf, Deutschland.

Type 2 Diabetes mellitus (T2 D) is an independent risk factor for cardiovascular diseases and non-ischemic heart failure, an underestimated complication of T2 D. Diastolic dysfunction is an early sign of diabetes-related heart failure preceding its progression to systolic damage. The etiology of heart failure in these patients has recently been partially unveiled. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0646-7871
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http://dx.doi.org/10.1055/a-0646-7871DOI Listing
February 2019
3 Reads

[Thoracic Aortic Aneurysms - Diagnosis and Treatment Strategies].

Dtsch Med Wochenschr 2019 Feb 31;144(3):146-151. Epub 2019 Jan 31.

Abteilung für Gefäßchirurgie, Vaskuläre und Endovaskuläre Chirurgie, Aortenzentrum des Klinikums der Ludwig-Maximilian-Universität, München.

Thoracic aortic aneurysms are a relatively uncommon disease, with an incidence of 10.4/100 000, with an increase in the last decades, due to the increased quality of vascular screening. Several imaging techniques like thoracic radiography, echocardiography, magnetic resonance (MRI) or positron emission tomography (PET) can be used for the diagnosis of such condition, whose first diagnosis is usually incidental. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0648-0207
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http://dx.doi.org/10.1055/a-0648-0207DOI Listing
February 2019
3 Reads

Cholesterol-Lowering Agents.

Circ Res 2019 Feb;124(3):364-385

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (W.K.).

Loss-of-function variants in PCSK9 (proprotein convertase subtilisin-kexin type 9) are associated with lower lifetime risk of atherosclerotic cardiovascular disease) events. Confirmation of these genetic observations in large, prospective clinical trials in participants with atherosclerotic cardiovascular disease has provided guidance on risk stratification and enhanced our knowledge on hitherto unresolved and contentious issues concerning the efficacy and safety of markedly lowering LDL-C (low-density lipoprotein cholesterol). PCSK9 has a broad repertoire of molecular effects. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313238DOI Listing
February 2019
1 Read

Heart failure among people with Type 2 diabetes mellitus: real-world data of 289 954 people from a diabetes database.

Diabet Med 2019 Jan 30. Epub 2019 Jan 30.

Institut für Epidemiologie und medizinische Biometrie, ZIBMT, Universität Ulm, Ulm.

Aim: Comparing people with Type 2 diabetes mellitus with and without heart failure in terms of metabolic control, therapeutic regimen and comorbidities.

Methods: The Prospective Diabetes Registry (DPV) is a longitudinal documentation system for demographics, medical care and outcome in people with diabetes mellitus. It consists of follow-up data from people with diabetes mellitus who have agreed to be recorded in the registry. Read More

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http://doi.wiley.com/10.1111/dme.13915
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http://dx.doi.org/10.1111/dme.13915DOI Listing
January 2019
7 Reads

[Merkel cell carcinoma].

Hautarzt 2019 Jan 30. Epub 2019 Jan 30.

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen, Deutschland.

Merkel cell carcinoma is a rare, highly aggressive skin tumor with neuroendocrine features found in older people. The pathogenesis is associated with immunosuppression, chronic UV light exposure and the Merkel cell polyomavirus. Clinically, Merkel cell carcinoma presents as a solitary, cutaneous or subcutaneous, red to bluish node. Read More

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http://dx.doi.org/10.1007/s00105-019-4360-5DOI Listing
January 2019

Interleukin-22 protects intestinal stem cells against genotoxic stress.

Nature 2019 Feb 30;566(7743):249-253. Epub 2019 Jan 30.

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Environmental genotoxic factors pose a challenge to the genomic integrity of epithelial cells at barrier surfaces that separate host organisms from the environment. They can induce mutations that, if they occur in epithelial stem cells, contribute to malignant transformation and cancer development. Genome integrity in epithelial stem cells is maintained by an evolutionarily conserved cellular response pathway, the DNA damage response (DDR). Read More

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http://www.nature.com/articles/s41586-019-0899-7
Publisher Site
http://dx.doi.org/10.1038/s41586-019-0899-7DOI Listing
February 2019
5 Reads