2,778 results match your criteria Desmoid Tumor


Autophagy inhibition overcomes sorafenib resistance in S45F-mutated desmoid tumors.

Cancer 2019 Apr 12. Epub 2019 Apr 12.

Program in Translational Therapeutics, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Background: Desmoid tumors (DTs) are rare and understudied fibroblastic lesions that are frequently recurrent and locally invasive. DT patients often experience chronic pain, organ dysfunction, decrease in quality of life, and even death.

Methods: Sorafenib has emerged as a promising therapeutic strategy, which has led to the first randomized phase 3 clinical trial devoted to DTs. Read More

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http://dx.doi.org/10.1002/cncr.32120DOI Listing

Desmoid tumor: A focus set on a challenging but understudied rare disease.

Authors:
Bernd Kasper

Cancer 2019 Apr 12. Epub 2019 Apr 12.

Sarcoma Unit, Interdisciplinary Tumor Center Mannheim, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1002/cncr.32119DOI Listing

[Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features: a clinicopathological analysis of five cases].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):282-287

Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To investigate the clinicopathological features, diagnosis and differential diagnosis of dedifferentiated liposarcoma (DDLPS) with inflammatory myofibroblastic tumor (IMT)-like features. Five cases of DDLPS with IMT-like features were collected from the First Affiliated Hospital of Nanjing Medical University, the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine and the First People's Hospital of Qinzhou between 2013 and 2018. EnVision method and fluorescence in situ hybridization (FISH) were used to detect the immunophenotype of the tumor cells and the profile of MDM2 gene amplification respectively. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.004DOI Listing
April 2019
1 Read

Survival outcomes after adjuvant radiotherapy for aggressive fibromatosis depend on time frame and nuclear β-catenin.

Radiat Oncol J 2019 Mar 31;37(1):37-42. Epub 2019 Mar 31.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To identify prognostic factors influencing progression-free survival (PFS) of aggressive fibromatosis (AF) after postoperative radiotherapy (PORT) and assess correlations between immunohistochemistry (IHC) features of β-catenin/smooth muscle actin (SMA) and PFS.

Materials And Methods: Records of 37 patients with AF treated by PORT from 1984 to 2015 were retrospectively reviewed. Fifteen patients underwent wide excision for AF and 22 patients received debulking operation. Read More

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http://dx.doi.org/10.3857/roj.2018.00542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453810PMC
March 2019
1 Read

Fibromatosis - immunohistochemical evaluation, differential diagnosis from gastrointestinal tumors, and other mesenchymal tumours.

Prz Gastroenterol 2019 12;14(1):79-85. Epub 2019 Mar 12.

Department of Pathology, Jan Kochanowski University, Kielce, Poland.

Introduction: Fibromatosis is a histologically benign growth of fibroblastic and myofibroblastic cells, with a potential to recur and invade local organs. It can occur as a superficial or deep form. Visceral fibromatosis and superficial fibromatosis are histologically similar. Read More

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http://dx.doi.org/10.5114/pg.2019.83429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444105PMC
March 2019
5 Reads

Not all abdominal masses after colorectal cancer surgery are malignant: intra-abdominal fibromatosis masquerading as recurrence.

Colorectal Dis 2019 Mar 30. Epub 2019 Mar 30.

Peritoneal Malignancy Institute, Basingstoke and North Hampshire Hospital, Basingstoke, UK.

Aim: Intra-abdominal fibromatosis is an unusual mesenchymal tumour that can be locally aggressive without any metastatic potential. Fibromatosis may simulate cancer recurrence on imaging surveillance for colorectal cancer follow-up. The optimal treatment of recurrent peritoneal malignancy is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Read More

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http://dx.doi.org/10.1111/codi.14626DOI Listing
March 2019
1 Read

The challenging case of a primigravid Bedouin woman with a dormant neck nodule that grew explosively during her pregnancy.

J Surg Case Rep 2019 Mar 20;2019(3):rjz061. Epub 2019 Mar 20.

Department of Surgery, Alexandria University School of Medicine, Alexandria, Egypt.

A Desmoid tumor in the neck is a rare tumor in an even more unusual site. Our patient was an 18-year-old primigravid Bedouin woman from northwest Egypt. She presented with a dormant neck nodule that grew explosively during her first pregnancy and stopped abruptly after delivery. Read More

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http://dx.doi.org/10.1093/jscr/rjz061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425158PMC
March 2019
1 Read

The CDK 4/6 inhibitor ribociclib has activity in the treatment of inoperable desmoid tumor. A case report.

Acta Oncol 2019 Mar 25:1-4. Epub 2019 Mar 25.

a Department of Oncology, Comprehensive Cancer Center , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.

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http://dx.doi.org/10.1080/0284186X.2019.1588992DOI Listing

Single institution experience of split course radiotherapy in patients with desmoid tumors.

Onco Targets Ther 2019 7;12:1741-1748. Epub 2019 Mar 7.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China,

Purpose: This study aimed to assess the feasibility of split course radiotherapy (SCRT) and reports long-term outcomes in patients with desmoid tumors (DT).

Patients And Methods: Between 2001 and 2004, 31 patients with recurrent (n=19) or primary large desmoid fibromatosis (≥10 cm) (n=12) who were treated with SCRT were retrospectively analyzed. All patients were treated with two phases of radiotherapy with a median interval time of 99 days (range: 81-122 days) and a median total dose of 6,399 cGy (range: 5,013-7,039 cGy). Read More

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http://dx.doi.org/10.2147/OTT.S189449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413754PMC
March 2019
2 Reads

Desmoid tumours of the head and neck: A case report.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 14. Epub 2019 Mar 14.

ENT department, Fattouma Bourguiba hospital, Monastir, Tunisia.

Introduction: Desmoid tumours of the head and neck, also known as fibromatosis, are rare, locally invasive benign tumours with high recurrence rate, causing considerable morbidity. Complete surgical excision of desmoid tumours is considered to be the only effective treatment.

Case Report: We present a case of fibromatosis of the right posterolateral region of the neck in a 56-year-old woman who presented with right neck mass. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.02.008DOI Listing

Clinical features and management of superficial fibromatoses.

J Dtsch Dermatol Ges 2019 Apr 13;17(4):393-397. Epub 2019 Mar 13.

Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.

Fibromatoses are a group of benign connective tissue tumors characterized by the infiltrative, aggressive proliferation of well-differentiated fibroblasts, leading to frequent local recurrence. Within this heterogeneous disease group, superficial fibromatoses show slower growth and more benign infiltration of surrounding tissues than deep fibromatoses. Superficial fibromatoses relevant to dermatology include palmar, plantar, and penile fibromatosis, knuckle pads, pachydermodactyly and infantile digital fibromatosis. Read More

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http://doi.wiley.com/10.1111/ddg.13808
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http://dx.doi.org/10.1111/ddg.13808DOI Listing
April 2019
4 Reads

Aggressive Fibromatosis of the Pancreas: A Rare Cause of Incomplete Duodenal Obstruction.

Pancreas 2019 03;48(3):e16-e17

Department of General Surgery Qilu Hospital, Shandong University Jinan, Department of Hepatobiliary Surgery People's Hospital of Liaocheng City Liaocheng, China Department of General Surgery Qilu Hospital, Shandong University Jinan,

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http://Insights.ovid.com/crossref?an=00006676-201903000-0002
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http://dx.doi.org/10.1097/MPA.0000000000001246DOI Listing
March 2019
6 Reads

Multimodal radiological imaging of collagenous fibroma arising from the subacromial region in a patient with osteosarcoma: A case report.

Mol Clin Oncol 2019 Mar 9;10(3):366-370. Epub 2019 Jan 9.

Department of Orthopaedics, Matsushita Memorial Hospital, Moriguchi, Osaka 570-8540, Japan.

Collagenous fibroma arising from the subacromial region is extremely rare. It is important to distinguish collagenous fibroma from other fibrous tumors including desmoid tumors, to differentiate between the prognoses and management strategies, including surgical treatment. The present case report describes the case of a 42-year-old man with a collagenous fibroma of the subacromial region. Read More

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http://dx.doi.org/10.3892/mco.2019.1798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388500PMC
March 2019
1 Read

A case with mesenteric desmoid tumor after laparoscopic resection of stage I sigmoid colon cancer.

Surg Case Rep 2019 Feb 28;5(1):38. Epub 2019 Feb 28.

Department of Surgery, Saitama Medical Center, Dokkyo Medical University, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan.

Background: Intra-abdominal desmoid tumors are rare and generally occur in some patients with familial adenomatous polyposis or secondary to an external stimulus such as surgical trauma. We report herein a case of intra-abdominal desmoid tumor in the jejunal mesentery after laparoscopic colectomy for sigmoid colon cancer.

Case Presentation: A 74-year-old woman underwent laparoscopic sigmoid colectomy for colon cancer with pathological stage I. Read More

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http://dx.doi.org/10.1186/s40792-019-0587-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395456PMC
February 2019
3 Reads

Percutaneous Cryoablation of an Extra-Abdominal Desmoid Tumor Abutting the Skin Surface and Peritoneum.

J Vasc Interv Radiol 2019 03;30(3):426-427

Department of Radiology and Imaging Sciences, University of Utah School of Medicine, 50 N. Medical Drive, Salt Lake City, UT 840132. Electronic address:

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http://dx.doi.org/10.1016/j.jvir.2018.09.033DOI Listing
March 2019
2 Reads

Desmoid tumor after resection of cerebellar hemangioblastoma.

J Neurosurg Sci 2019 Apr;63(2):224-230

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.

Desmoid tumors are histologically benign but locally invasive tumors that rarely can occur in the head and neck. In this article, we illustrate a rare case of desmoid tumor formation in intracranial posterior fossa after suboccipital craniotomy for hemangioblastoma. A 43-year-old woman presented with headaches, dizziness, equilibrium disorders, nausea, and vomiting due to a hemangioblastoma in posterior fossa. Read More

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http://dx.doi.org/10.23736/S0390-5616.16.03398-1DOI Listing
April 2019
3 Reads
0.780 Impact Factor

Acute Respiratory Failure With a Rare, Rapidly Progressing Pediatric Desmoid Tumor Anterior Mediastinal Mass.

Pediatr Emerg Care 2019 Feb 20. Epub 2019 Feb 20.

From the Department of Emergency Medicine, Baylor Scott and White Health; and College of Medicine, Texas A&M Health Science Center, Temple, TX.

We present an unusual case of a 6-year-old boy who presented with the sudden presence of left neck mass and acute hypoxemic respiratory failure, whose subsequent imaging demonstrated a previously undiagnosed anterior mediastinal mass (AMM) extending into the left neck. Biopsy of the mass was consistent with a desmoid tumor, which is a rare cause of AMM in children. Desmoid tumors are locally aggressive, often invading and enveloping surrounding tissues, but overall slow growing. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001772DOI Listing
February 2019
2 Reads

Spontaneous regression of a sporadic intra-abdominal located desmoid-type fibromatosis.

J Surg Case Rep 2019 Feb 12;2019(2):rjz037. Epub 2019 Feb 12.

Department of Surgery, Medisch Spectrum Twente, Enschede, The Netherlands.

Background: Desmoid-type fibromatosis (DTF) is a rare benign proliferation of myofibroblasts with an unpredictable disease course. Treatment of intra-abdominal located DTF is difficult because of the close relationship with vital organs.

Case Presentation: A healthy young male presents with an asymptomatic palpable mass in the lower right abdominal quadrant. Read More

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http://dx.doi.org/10.1093/jscr/rjz037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371851PMC
February 2019

Desmoid-type fibromatosis arising in a bifid rib chest wall.

Gen Thorac Cardiovasc Surg 2019 Feb 21. Epub 2019 Feb 21.

Division of Thoracic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minatoku, Tokyo, 105-0003, Japan.

Desmoid-type fibromatosis is a rare soft tissue tumor and the chest wall is one of the common sites of its extra-abdominal occurrence. A bifid rib is one of the congenital rib abnormalities. We report a case of desmoid-type fibromatosis arising in a chest wall's bifid rib. Read More

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http://dx.doi.org/10.1007/s11748-019-01088-5DOI Listing
February 2019

Large desmoid tumors in familial adenomatous polyposis: a successful outcome.

Autops Case Rep 2018 Oct-Dec;8(4):e2018045. Epub 2018 Sep 26.

Centro Hospitalar de São João, Department of Surgery. Porto, Portugal.

Desmoid tumors develop from connective tissue, fasciae, and aponeuroses, and may occur in the context of familial adenomatous polyposis or may arise sporadically; also, they may be extra-abdominal, intra-abdominal, or located in the abdominal wall. These benign tumors have a great aggressiveness with a high rate of local recurrence. Familial adenomatous polyposis is an inherited condition with autosomal dominant transmission, and is characterized by the development of multiple colonic and rectal adenomatous polyps, as well as desmoid tumors. Read More

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http://dx.doi.org/10.4322/acr.2018.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360820PMC
September 2018

The etiology, evaluation, and management of plantar fibromatosis.

Orthop Res Rev 2019 17;11:1-7. Epub 2018 Dec 17.

Albany Medical College Division of Orthopaedic Surgery, Albany, NY, USA,

Plantar fibromatosis (Ledderhose disease) is a rare, benign, hyperproliferative fibrous tissue disorder resulting in the formation of nodules along the plantar fascia. This condition can be locally aggressive, and often results in pain, functional disability, and decreased quality of life. Diagnosis is primarily clinical, but MRI and ultrasound are useful confirmatory adjuncts. Read More

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https://www.dovepress.com/the-etiology-evaluation-and-manage
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http://dx.doi.org/10.2147/ORR.S154289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367723PMC
December 2018
9 Reads

[Two Cases of Resectable Intra-Abdominal Desmoid Tumor after Laparoscopic Gastrectomy for Gastric Cancer].

Gan To Kagaku Ryoho 2019 Jan;46(1):118-120

Dept. of Gastroenterological Surgery, Sendai Kousei Hospital.

Case 1: A 52-year-old man underwent laparoscopic total gastrectomy for gastric cancer. After 2 years, a follow-up computed tomography(CT)scan showed a large, solid 10 cm-sized mass in his left upper abdomen. Under the diagnosis of a suspected mesenchymal tumor, a tumor resection with a partial resection of the upper jejunum and transverse colon was performed. Read More

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January 2019
1 Read

Rapidly growing breast desmoid tumor with intra-thoracic involvement after reconstructive surgery for breast cancer.

Breast J 2019 Mar 12;25(2):307-309. Epub 2019 Feb 12.

Department of Surgical Oncology, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.

Desmoid tumors are very rare soft tissue neoplasia that are slow growing and locally aggressive. They grow anywhere in the body and are rarely develop in the breast . Histopathologic examination confirms diagnosis. Read More

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http://doi.wiley.com/10.1111/tbj.13212
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http://dx.doi.org/10.1111/tbj.13212DOI Listing
March 2019
9 Reads

Estrogen receptor beta expression correlates with proliferation in desmoid tumors.

J Surg Oncol 2019 Feb 11. Epub 2019 Feb 11.

Department of Oncology, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background And Objectives: Estrogen receptor signaling and cyclin D1 have a major role in tumor cell proliferation in breast cancer. Desmoid tumors are rare neoplasms that may respond to endocrine treatment. The present study aimed to investigate the expression levels and the clinical relevance of estrogen receptor beta (ERβ) and cyclin D1 in desmoid tumors. Read More

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http://dx.doi.org/10.1002/jso.25407DOI Listing
February 2019
2 Reads

Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373620PMC
February 2019
18 Reads

A Rare Case of Extra-abdominal Desmoid-type Fibromatosis Arising from the Popliteal Fossa.

Cureus 2018 Nov 28;10(11):e3651. Epub 2018 Nov 28.

Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar, IND.

Desmoids are rare soft-tissue tumors of the abdominal wall that may sporadically occur extra-abdominally. It manifests as clonal fibroblastic proliferation with an infiltrative tendency and capacity to recur without metastasizing. An adolescent male presented with a gradually increasing globular, non-tender, firm, non-pulsatile swelling (8 × 5 × 3 cm) in the left popliteal fossa that had been present for five months. Read More

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https://www.cureus.com/articles/16190-a-rare-case-of-extra-a
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http://dx.doi.org/10.7759/cureus.3651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351114PMC
November 2018
9 Reads

Refractory and metastatic infantile fibrosarcoma harboring fusion shows complete and durable response to crizotinib.

Cold Spring Harb Mol Case Stud 2019 Feb 1;5(1). Epub 2019 Feb 1.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA.

Infantile fibrosarcoma (IFS) is a rare soft-tissue sarcoma, which classically presents as an aggressive and rapidly enlarging tumor over the distal extremities of children in their first year of life. The presence of and gene rearrangement is characteristic of IFS, which can be detected on routine fluorescence in situ hybridization (FISH) testing. Patients with IFS typically respond well to surgical resection and chemotherapy and have an overall survival of ∼90%. Read More

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http://dx.doi.org/10.1101/mcs.a003376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371745PMC
February 2019
1 Read

Desmoid-type Fibromatosis of the Breast Mimicking Carcinoma.

J Belg Soc Radiol 2019 Jan 29;103(1):13. Epub 2019 Jan 29.

GZA Hospitals, BE.

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http://dx.doi.org/10.5334/jbsr.1612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354018PMC
January 2019
2 Reads

The Emerging Role of Surgery for Patients With Advanced Melanoma Treated With Immunotherapy.

J Surg Res 2019 Apr 20;236:209-215. Epub 2018 Dec 20.

Department of Surgery, Duke University, Durham, North Carolina.

Background: The emergence of immune checkpoint inhibitors (ICIs) has improved survival for patients with metastatic melanoma. The types of disease-response patterns to ICI therapy can be more complex relative to traditional chemotherapy and include mixed responses, pseudoprogression, and oligoprogression. The potential benefit of surgery after incomplete response to ICI therapy has not been explored. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.045DOI Listing

[Resection of a Desmoid Tumor Originating from the Greater Omentum after Surgery for Colon Cancer and Liver Metastasis-A Case Report].

Gan To Kagaku Ryoho 2018 Dec;45(13):2444-2446

Dept. of Surgery, Suita Municipal Hospital.

Here, we report the case of a 66-year-old male patient who previously underwent resection of sigmoid colon cancer and its liver metastasis. His follow-up contrast-enhanced CT scan revealed a mass shadow at around the gastrosplenic ligament, which gradually increased in size. Because it could not be pathologically diagnosed by transgastric EUS-FNA, en bloc resection wasperformed surgically for the tumor in the greater omentum. Read More

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December 2018
2 Reads

En bloc resection for intra-abdominal/retroperitoneal desmoid-type fibromatosis with adjacent organ involvement: A case series and literature review.

Biosci Trends 2018 ;12(6):620-626

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Hepato-PancreatoBiliary Surgery, Peking University Cancer Hospital and Institute.

Surgical treatment for intra-abdominal/retroperitoneal desmoid-type fibromatosis (IA/RPDF) is still controversial. Studies regarding en bloc resection in IA/RPDF with adjacent organ involvement are scanty. This study aims to evaluate the safety and effectiveness of en bloc resection in IA/RPDF with adjacent organ involvement. Read More

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http://dx.doi.org/10.5582/bst.2018.01285DOI Listing
January 2018

Cryotherapy efficacy and safety as local therapy in surgical treatment of musculoskeletal tumours. A retrospective case series of 143 patients.

J Biol Regul Homeost Agents 2018 Nov-Dec;32(6 Suppl. 1):65-70

Second Orthopedic Division, Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Italy.

Cryotherapy, also called Cryoablation (CA), is a technique that provides a local treatment to various pathological conditions. In Musculoskeletal tumours management, Cryoablation is well accepted and validated as a treatment in palliative cures for metastatic patients. Recently, CA has been proposed also as an alternative to radiofrequency ablation in osteoid osteoma and other benign tumour treatment with promising results. Read More

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January 2019
6 Reads

Desmoid Tumor Presenting as a Typical Cervical Dumbbell Tumor:A Case Report and Literature Review.

World Neurosurg 2019 Jan 10. Epub 2019 Jan 10.

Department of Spinal Surgery, Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou, China. Electronic address:

Background: Dumbbell-shaped tumor is a type of the inner and outer cervical spinal canal tumor, and most of them are neurogenic tumors. Desmoid tumor is a rare tumor, and no case of them involving intervertebral foramen formed dumbbell-shaped in cervical spine have been reported before in English literature. Here we report a case of desmoid tumor arising in the cervical spine which is presented as typical dumbbell-shaped tumor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193003
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http://dx.doi.org/10.1016/j.wneu.2019.01.001DOI Listing
January 2019
9 Reads

A Desmoid Tumor Involving the Subscapularis Muscle: A Case Report.

JBJS Case Connect 2019 Jan-Mar;9(1):e3

Massachusetts General Hospital, Boston, Massachusetts.

Case: A 31-year-old woman developed worsening pain and paresthesia in the neck, shoulder, and arm over a period of 6 years. Magnetic resonance imaging revealed a soft-tissue mass in the subscapular region, with likely involvement of the scapula and the subscapularis muscle. The mass was resected, and the final histologic diagnosis was desmoid-type fibromatosis. Read More

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http://dx.doi.org/10.2106/JBJS.CC.18.00184DOI Listing
January 2019

Recurrent Desmoid Tumor of the Neck: A Case Report of a Benign Disease with Aggressive Behavior.

Case Rep Otolaryngol 2018 28;2018:6573587. Epub 2018 Nov 28.

Department of Otorhinolaryngology, University of Crete Medical School, Heraklion, Crete, Greece.

We present a case of a desmoid tumor recurrence in a patient with a history of a resected desmoid tumor of the right neck area with free surgical margins six months earlier. The neoplasm was found to invade the parapharyngeal space, and wide excision was performed including most of the sternocleidomastoid muscle (SCM), the thrombosed internal jugular vein (IJV), and the infiltrated spinal accessory nerve (SAN). The histopathologic findings displayed free microscopic margins, with close margins at the site of the parapharyngeal space extension. Read More

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https://www.hindawi.com/journals/criot/2018/6573587/
Publisher Site
http://dx.doi.org/10.1155/2018/6573587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304189PMC
November 2018
2 Reads

A giant mesenteric fibromatosis involving the muscular layer of the colon wall: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e14015

Department of Hepatobiliary Surgery, Clinical Nutrition Support Center, Binzhou Medical University Hospital.

Rationale: Mesenteric fibromatosis (MF) is a rare tumor whose biological behavior is intermediate between benign fibrous neoplasms and fibrosarcomas, and the characteristic of these tumors are local aggressive lesions which is prone to local recurrence but non-metastasizing. The common symptom is abdominal distention or painless mass. We report a case of giant MF in abdominal cavity with abdominal distention as the main symptom. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901040-0006
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http://dx.doi.org/10.1097/MD.0000000000014015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344171PMC
January 2019
4 Reads

Sino-orbital desmoid tumor in a pediatric patient - Case report with review of literature.

Orbit 2018 Dec 27:1-9. Epub 2018 Dec 27.

e Department of Pediatric Oncology , National University Health System , Singapore , Singapore.

We report a case of a 2-year-old female who presented with bilateral progressive proptosis, visual loss, nasal obstruction, and breathing difficulty. Magnetic resonance imaging revealed a large sino-orbital mass that was extending to the orbital apex and skull base. An initial diagnosis of rhabdomyosarcoma was made elsewhere on the basis of the presence of round and spindle cell tumor. Read More

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http://dx.doi.org/10.1080/01676830.2018.1556306DOI Listing
December 2018
3 Reads

Laryngeal reconstruction for recurrent desmoid tumor using three-dimensional modeling: A unique approach for a rare tumor.

Laryngoscope 2018 Dec 25. Epub 2018 Dec 25.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina Hospital, Chapel Hill, North Carolina, U.S.A.

Desmoid tumors are exceedingly rare within the larynx and cause significant morbidity due to their locally aggressive and infiltrative nature. Surgery is the mainstay of treatment with previous reports describing total and near-total laryngectomy for cure. We present a case of recurrent glottic desmoid tumor managed with hemilaryngectomy and reconstructed with temporoparietal free tissue, rib, and buccal grafts. Read More

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http://dx.doi.org/10.1002/lary.27756DOI Listing
December 2018
2 Reads

Sorafenib for Advanced and Refractory Desmoid Tumors.

N Engl J Med 2018 12;379(25):2417-2428

From Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center (M.M.G., W.D.T., N.H., N.P.A., R.A.L., Y.M., R.Y.) and Columbia University Vagellos College of Physicians and Surgeons and New York Presbyterian Hospital (L.H.S., G.K.S.), New York, and Northwell Cancer Institute and Cold Spring Harbor Laboratory, Lake Success (R.G.M.) - all in New York; Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN (M.R.M.); Washington University School of Medicine, St. Louis (B.A.V.T.); M.D. Anderson Cancer Center, University of Texas, Houston (V.R.); Mayo Clinic in Florida, Jacksonville (S.A.); Yale University, New Haven, CT (H.A.D.); University Health Network Princess Margaret Cancer Centre, Toronto (A.A.G.); University of Iowa-Holden Comprehensive Cancer Center, Iowa City (M.M.M.); University of Alabama at Birmingham Cancer Center, Birmingham (R.M.C.); Fox Chase Cancer Center, Philadelphia (S.M.); Georgetown University, Lombardi Comprehensive Cancer Center, Washington, DC (M.J.P.); Duke Cancer Institute, Duke University Medical Center, Durham (R.F.R.), and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill (E.B.) - both in North Carolina; Dayton National Cancer Institute Community Oncology Research Program, Dayton, OH (T.S.); National Cancer Institute, Bethesda, MD (J.J.W.); and the Alliance Statistics and Data Center, Mayo Clinic, Scottsdale, AZ (A.C.D.).

Background: Desmoid tumors (also referred to as aggressive fibromatosis) are connective tissue neoplasms that can arise in any anatomical location and infiltrate the mesentery, neurovascular structures, and visceral organs. There is no standard of care.

Methods: In this double-blind, phase 3 trial, we randomly assigned 87 patients with progressive, symptomatic, or recurrent desmoid tumors to receive either sorafenib (400-mg tablet once daily) or matching placebo. Read More

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http://dx.doi.org/10.1056/NEJMoa1805052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447029PMC
December 2018
15 Reads

Clinical prognostic factors for pediatric extra-abdominal desmoid tumor: analyses of 66 patients at a single institution.

World J Surg Oncol 2018 Dec 18;16(1):237. Epub 2018 Dec 18.

Department of Pediatric Orthopaedic, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background And Purpose: Pediatric desmoid tumor (PDT) is rare and has a high local recurrence rate. The purpose of the present study was to analyze clinical risk factors of local recurrence in PDT patients.

Materials And Methods: We reviewed clinical data of 66 PDT patients from 2004 to 2015. Read More

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http://dx.doi.org/10.1186/s12957-018-1536-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299634PMC
December 2018
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Desmoid Fibromatosis Mimicking Metastatic Recurrence After Pancreatectomy for Pancreatic Adenocarcinoma.

Mayo Clin Proc Innov Qual Outcomes 2018 Dec 20;2(4):392-397. Epub 2018 Sep 20.

Department of Radiology, Mayo Clinic, Rochester, MN.

Desmoid fibromatosis is a rare, neoplastic tumor known for its aggressive local invasion and recurrence after surgery. Tumors can occur sporadically or associated with familial adenomatous polyposis. We present 3 cases of desmoid fibromatosis postpancreatectomy for pancreatic adenocarcinoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25424548183008
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http://dx.doi.org/10.1016/j.mayocpiqo.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260471PMC
December 2018
15 Reads

Abnormal Presentation of Aggressive Fibromatosis After Radiotherapy for Keloids: Case Report and Brief Literature Review.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Rationale: Keloids, dermal fibroproliferative lesions, often occur secondary to skin injury and extend beyond the margins of the original lesion. Aggressive fibromatosis (AF) is a rare condition arising from fibroblasts and is characterized clinically as a nonmetastasizing but locally invasive tumor. In this work, we present the case of a patient who developed AF in the chest 3 years after surgery and postoperative radiotherapy for keloids. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001675DOI Listing
December 2018
6 Reads

Long-Term Outcomes for Patients With Desmoid Fibromatosis Treated With Radiation Therapy: A 10-Year Update and Re-evaluation of the Role of Radiation Therapy for Younger Patients.

Int J Radiat Oncol Biol Phys 2019 Apr 12;103(5):1167-1174. Epub 2018 Dec 12.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Purpose: To update our experience with long-term outcomes in patients with desmoid fibromatosis treated with radiation therapy (RT) and to characterize factors associated with increased risk of local recurrence.

Methods And Materials: We reviewed the records of 209 consecutive patients with desmoid fibromatosis treated with RT, either alone or as combined-modality therapy (CMT) with surgery, at our institution from 1965 to 2015.

Results: Median follow-up time was 98 months (range, 1-509 months). Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.12.012DOI Listing
April 2019
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Aggressive fibromatosis of the parotid gland.

Ear Nose Throat J 2018 Dec;97(12):E28-E30

Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Extra-abdominal fibromatosis (EAF) is a rare, locally aggressive tumor that originates in fascial structures. It accounts for less than 0.3% of all tumors diagnosed. Read More

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December 2018
21 Reads

A Case of Primary Intra-abdominal Synovial Sarcoma.

Indian J Surg Oncol 2018 Dec 22;9(4):636-639. Epub 2018 May 22.

2Department of General and Gastrointestinal Surgery, Medical Trust Hospital, M.G. Road, Kochi, Kerala 682016 India.

Synovial sarcomas are relatively common intermediate-to-high-grade malignant soft tissue tumors, often with an initial indolent course. And among the sarcomas primary intra-abdominal synovial sarcoma is a relatively rare entity that may present with an abdominal mass and diagnosis is usually confirmed by immunohistochemistry. The authors report a case of a 46-year-old man who presented with a large palpable abdominal mass. Read More

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http://dx.doi.org/10.1007/s13193-018-0783-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265165PMC
December 2018
3 Reads

Clinical, histological and therapeutic modern approach of Ledderhose disease.

Rom J Morphol Embryol 2018 ;59(3):691-697

Department of Anesthesiology and Intensive Care, Emergency Clinical Hospital of Bucharest, Romania;

Ledderhose disease or plantar fibromatosis is a rare hyperproliferative disorder of the plantar aponeurosis, clinically characterized by nodules situated especially on the medial border of the foot. It is histopathologically associated with Dupuytren's disease. This disease has some risk factors, like old age, alcohol or nicotine abuse, liver dysfunction, trauma or exposure to vibrations and autoimmune disorders, but the exact etiology is still unknown. Read More

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December 2018
25 Reads