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    Efficacy of vinorelbine combined with low-dose methotrexate for treatment of inoperable desmoid tumor and prognostic factor analysis.
    Chin J Cancer Res 2017 Oct;29(5):455-462
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Bone and Soft Tissue Tumors, Peking University Cancer Hospital & Institute, Beijing 100142, China.
    Objective: To assess the efficacy of conservative chemotherapy for inoperable desmoid tumor (DT) and analyze the prognostic factors.

    Methods: From November 2008 to April 2016, 71 patients of inoperable DT were treated with vinorelbine and low-dose methotrexate in the Department of Bone and Soft Tissue Tumors, Peking University Cancer Hospital & Institute, and enrolled in this retrospective study. The chemotherapy duration is one year. Read More

    Effect of surgical margins on prognosis in aggressive fibromatosis: A single-institutional analysis of 90 patients.
    Oncol Lett 2017 Nov 1;14(5):5129-5134. Epub 2017 Sep 1.
    Department of Plastic Surgery, BG-University Hospital Bergmannsheil, D-44789 Bochum, Germany.
    The treatment of aggressive fibromatosis poses a therapeutic challenge in an interdisciplinary setting. The extent of surgical resection is still discussed controversially. The present retrospective analysis aimed to determine prognostic factors leading to recurrence. Read More

    [Resection of a Chest Wall Desmoid Tumor with Chest Wall Reconstruction;Report of a Case].
    Kyobu Geka 2017 Nov;70(12):1041-1043
    Department of Thoracic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
    A primary desmoid tumor arising from the chest wall is extremely rare. We report the case of a 57-year-old man presenting with a desmoid tumor arising from his chest wall. Chest radiograph at a regular medical checkup indicated an abnormal shadow. Read More

    Safety and efficacy of intralesional steroid injection for aggressive fibromatosis.
    World J Surg Oncol 2017 Nov 2;15(1):195. Epub 2017 Nov 2.
    Bangkok Hospital Chiang Mai, Chiang Mai, Thailand.
    Background: Treatment of recurrent aggressive fibromatosis (AF) following surgical resection is a clinical challenge. Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to be an effective option for controlling the disease. However, long-term NSAID use can result in unfavorable complications. Read More

    Sonography used in the infantile desmoid fibromatosis of postcricoid area: A case report.
    Medicine (Baltimore) 2017 Nov;96(44):e8500
    aDepartment of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University bDepartment of Pathology, Beijing Tongren Hospital, Capital Medical University cDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University dDepartment of Diagnostic Ultrasound, Beijing Aerospace General Hospital, Beijing, China.
    Rationale: Infantile desmoid fibromatosis of the postcricoid area is a rare disease and is characterized by a proliferation of fibrous tissue with non-metastasis, local infiltration, and a high rate of recurrence after surgical resection. Currently, ultrasound is scarcely used in the hypopharynx and larynx area.

    Patient Concerns: A 4-year-old boy presented with hoarseness, deep voice and snoring for 2∼4 years without any surgical history. Read More

    Late Presentation of Aggressive Fibromatosis Involving Head, Neck and Chest Wall.
    J Coll Physicians Surg Pak 2017 Oct;27(10):654-656
    Department of Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
    Fibromatosis is a rare, benign, slow-growing and locally infiltrative tumour, caused by uncontrolled proliferation of fibrous tissue arising from muscles, connective tissue, fasciae and aponeurosis. It is also called desmoid tumour, which is very rare pathology representing only 0.03% of all neoplasms in human and around 3% of all soft tissue tumours. Read More

    Laparoscopic Resection of a Jejunal Mesenteric Pseudocyst.
    Case Rep Gastroenterol 2017 Sep-Dec;11(3):526-530. Epub 2017 Sep 13.
    Department of Gastroenterological Surgery II, Hokkaido University Hospital, Sapporo, Japan.
    An unusual case of a jejunal mesenteric pseudocyst treated by laparoscopic resection is reported. A 44-year-old woman was admitted to our hospital with intermittent upper abdominal pain and diarrhea. Physical examination revealed slight periumbilical tenderness, and no masses were palpable. Read More

    Desmoid type fibromatosis: A case report with an unusual etiology.
    World J Gastrointest Oncol 2017 Sep;9(9):385-389
    Internal Medicine Department of Research Medical Center and Research Department of Kansas City Veterans Affairs Medical Center, Kansas City, MO 64132, United States.
    Desmoid type fibromatosis (DTF) is a rare, locally invasive, non-metastasizing soft tissue tumor. We report an interesting case of DTF involving the pancreatic head of a 54-year-old woman. She presented with intermittent dysphagia and significant weight loss within a 3-mo period. Read More

    An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG).
    Ann Oncol 2017 Oct;28(10):2399-2408
    Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
    Desmoid-type fibromatosis is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. Currently, there is no established or evidence-based treatment approach available for this disease. Therefore, in 2015 the European Desmoid Working Group published a position paper giving recommendations on the treatment of this intriguing disease. Read More

    A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors.
    Clin Cancer Res 2017 Sep 27. Epub 2017 Sep 27.
    University of Michigan, Ann Arbor, Michigan.
    Purpose: Wnt signaling is implicated in tumor cell dedifferentiation and cancer stem cell function. Ipafricept (OMP-54F28) is a first-in-class recombinant fusion protein with the extracellular part of human frizzled 8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands. This trial evaluated ipafricept in patients with solid tumors. Read More

    Effects of ICOS+ T cell depletion via afucosylated monoclonal antibody MEDI-570 on pregnant cynomolgus monkeys and the developing offspring.
    Reprod Toxicol 2017 Sep 13;74:116-133. Epub 2017 Sep 13.
    Toxicology, Research & Development, MedImmune Inc., One MedImmune Way, Gaithersburg, MD 20854, United States.
    MEDI-570 is a fully human afucosylated monoclonal antibody (MAb) against Inducible T-cell costimulator (ICOS), highly expressed on CD4+ T follicular helper (TFH) cells. Effects of MEDI-570 were evaluated in an enhanced pre-postnatal development toxicity (ePPND) study in cynomolgus monkeys. Administration to pregnant monkeys did not cause any abortifacient effects. Read More

    [Latissimus dorsi flap in reconstruction following treatment of giant tumor of the abdominal wall: about a rare case].
    Pan Afr Med J 2017 6;27:181. Epub 2017 Jul 6.
    Service de Chirurgie Plastique, Hôpital Avicenne, Rabat, Maroc.
    We report the case of a 16-year old patient presenting with giant, multinodular, mesenchymal tumor of the abdominal wall occupying the left abdominal region and measuring 25 cm on the vertical axis, 20 cm on the transverse axis, mobile when compared with the deep structures and gradually increasing in volume over childhood and neglected. After small biopsy, which showed desmoid tumor, the patient underwent complete surgical resection of the tumor with immediate reconstruction by free muscolo skin flap of the latissimus dorsi attached to the large blood vessels of the inguinal fold (left iliac artery and left external iliac vein), connected by termino lateral anastomosis. Flap survival was correctly performed and reconstruction was successful. Read More

    Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens.
    Am J Clin Pathol 2017 Aug;148(2):179-189
    Department of Pathology, Brigham and Women's Hospital, Boston, MA.
    Objectives: Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2 (PRC2), have been identified in 70% to 92% of MPNSTs; PRC2 inactivation leads to loss of trimethylation of lysine 27 of histone H3 (H3K27me3). We evaluated the utility of H3K27me3 immunohistochemistry for distinguishing MPNST from its cytomorphologic mimics. Read More

    Outcomes and complications of radiation therapy in patients with familial adenomatous polyposis.
    J Gastrointest Oncol 2017 Aug;8(4):643-649
    Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah; Salt Lake City, UT, USA.
    Background: The outcomes, complications, and rates of secondary malignancies from radiation therapy (RT) are not known for patients with familial adenomatous polyposis (FAP).

    Methods: We queried the Hereditary Gastrointestinal Cancer Registry (HGCR) for patients with FAP who received RT. Outcomes assessed included acute and late treatment toxicity and secondary malignancies. Read More

    Long-Term Follow-Up of Desmoid Fibromatosis Treated with PF-03084014, an Oral Gamma Secretase Inhibitor.
    Ann Surg Oncol 2017 Sep 8. Epub 2017 Sep 8.
    Division of Medical Oncology, University of Colorado Denver School of Medicine - Anschutz Medical Campus, Aurora, CO, USA.
    Background: Desmoid fibromatosis is a fibroblastic neoplasm driven by aberrations within the WNT pathway, exhibiting mutations in β-catenin or APC. We review the long-term follow-up of patients in a phase I study treated with an oral gamma secretase inhibitor, PF-03084014.

    Methods: PF-03084014 was administered orally at doses ranging from 20 to 330 mg twice daily. Read More

    Rarity among benign gastric tumors: Plexiform fibromyxoma - Report of two cases.
    World J Gastroenterol 2017 Aug;23(31):5817-5822
    Institute of Pathology, Medical University of Graz, 8036 Graz, Austria.
    Plexiform fibromyxoma is a very rare mesenchymal tumor of the stomach, found almost exclusively in the antrum/pylorus region. The most common presenting symptoms are anemia, hematemesis, nausea and unintentional weight loss, without sex or age predilection. We describe here two cases of plexiform fibromyxoma, involving a 16-year-old female and a 34-year-old male. Read More

    Effective treatment of aggressive fibromatosis with celecoxib guided by genetic testing.
    Cancer Biol Ther 2017 Oct 7;18(10):757-760. Epub 2017 Sep 7.
    a Department of Oncology , The Affiliated Hospital of Qingdao University , Qingdao , Shandong , China.
    Aggressive fibromatosis (AF) or desmoid tumors is an aggressive fibroblastic proliferation which is locally invasive but can not metastasize. The treatment of AF is challenging. Surgery was the main treatment modality for AF in the past, other strategies including radiotherapy, systemic therapies and wait-and-see policy. Read More

    Diaphragm reconstruction combined with thoraco-abdominal wall reconstruction after tumor resection.
    J Plast Surg Hand Surg 2017 Aug 31:1-6. Epub 2017 Aug 31.
    a Department of Plastic Surgery , Helsinki University Hospital , Helsinki , Finland.
    Background: Thoraco-abdominal wall resection including diaphragm resection results in a challenging surgical defect. Various methods have been used for diaphragm reconstruction. The aim of this study was to describe our methods of diaphragm and thoraco-abdominal wall reconstruction after combined resection of these anatomical structures. Read More

    Expanding the borders: Image-guided procedures for the treatment of musculoskeletal tumors.
    Diagn Interv Imaging 2017 Sep 23;98(9):635-644. Epub 2017 Aug 23.
    Interventional Imaging, Nouvel hopital civil, 1, place de l'Hôpital, 67098 Strasbourg cedex, France. Electronic address:
    Interventional radiology has revolutionized the local management of bone tumours, offering new minimal invasive alternatives to surgery and radiotherapy. Its role has continuously increased over the past years for the treatment of benign tumors and also of some malignant ones, especially in palliative situations. The development of protective techniques and new ablative technologies, such as cryoablation, contributes to expand the role of the interventional radiologist to new fields of applications in musculoskeletal oncology. Read More

    Desmoid Tumor and Silicone Breast Implant Surgery: Is There Really a Connection? A Literature Review.
    Aesthetic Plast Surg 2017 Aug 25. Epub 2017 Aug 25.
    Plastic and Reconstructive Surgery Department, Soroka University Medical Center, Ben Gurion University of Negev, Beersheba, Israel.
    Background: Desmoid tumors are borderline tumors of the connective tissue, arising in the musculo-aponeurotic stromal elements. A desmoid tumor (DT) has an infiltrative and locally aggressive growth pattern and usually does not metastasize; however, it has a high recurrence and complication rate. DT located in the breast (BDT) represents a rare extra-abdominal form. Read More

    Radiologic images of an aggressive implant-associated fibromatosis of the breast and chest wall: case report and review of the literature.
    Radiol Case Rep 2017 Sep 28;12(3):431-438. Epub 2017 Jun 28.
    Department of Radiology, Cooper University Hospital, 1 Cooper Plaza, Suite B23, Camden, NJ 08103, USA.
    Fibromatosis of the breast is a rare benign disease compromising <0.2% of all primary breast tumors. Although the chest wall is a common location, occurrences of implant-associated fibromatosis of the breast are extremely rare; only 33 cases have been reported. Read More

    Aggressive fibromatosis of the oral cavity in a 5 year old boy: a rare case report.
    Pan Afr Med J 2017 18;27:47. Epub 2017 May 18.
    Department of Oral Medicine and Radiology Bapuji Dental College and Hospital MCC B Block, Davangere, Karnataka, India.
    Fibrous tissue proliferations express a wide spectrum of histologic and morphologic variation in both infants and adults. This ranges from hypertrophic scar formation at one end to malignant fibrosarcoma at the other end of the spectrum. Aggressive fibromatosis is an intermediate tumor which is in proximity to fibrosarcomas. Read More

    Management of desmoid tumours: A large national database of familial adenomatous patients shows a link to colectomy modalities and low efficacy of medical treatments.
    United European Gastroenterol J 2017 Aug 28;5(5):735-741. Epub 2016 Oct 28.
    Gastroenterology Department, Edouard Herriot Hospital, Lyon, France.
    Background: Desmoid tumours represent a major complication of familial adenomatous polyposis. Our aims were to study the factors associated with the development of desmoid tumours in familial adenomatous polyposis patients, and to describe presentation and management of desmoid tumours.

    Methods And Patients: We reviewed all patients with familial adenomatous polyposis followed at our institution between 1965-2013, with either identified adenomatous polyposis coli gene mutation, or a personal and family history suggesting adenomatous polyposis coli-related polyposis. Read More

    Giant pancreatic solid cystic desmoid tumor with two ectopic adrenal tissues.
    Turk J Gastroenterol 2017 Sep 9;28(5):401-404. Epub 2017 Aug 9.
    Department of Pathology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
    A 19-year-old woman presented with painless swelling of the abdomen. During surgery, a giant mass measuring 37 cm×26 cm×12 cm within the distal pancreas invading the spleen was noted. The clinical diagnosis of a solid cystic pseudopapillary tumor of the pancreas was suspected. Read More

    Desmoid-type fibromatosis of the breast: A report of 2 cases.
    Oncol Lett 2017 Aug 7;14(2):1433-1438. Epub 2017 Jun 7.
    Second Department of Gynecology and Obstetrics, Comenius University of Bratislava, Faculty of Medicine, 82606 Bratislava, Slovakia.
    Mammary fibromatosis is a rare and locally aggressive benign tumor of the breast; it originates from fibroblasts and myofibroblasts within the breast parenchyma and does not metastasize. The condition is locally aggressive and has a high rate of recurrence. The etiology of mammary fibromatosis is unknown. Read More

    Concurrent Imatinib and Radiation Therapy for Unresectable and Symptomatic Desmoid Tumors.
    Sarcoma 2017 5;2017:2316839. Epub 2017 Jul 5.
    Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA.
    Desmoid tumors are locally aggressive fibroproliferative neoplasms that can lead to pain and dysfunction due to compression of nerves and surrounding structures. Desmoid tumors often progress through medical therapy, and there is frequently a delay of multiple months before radiation can provide symptomatic relief. To achieve more rapid symptomatic relief and tumor regression for unresectable desmoid tumors causing significant morbidity such as brachial plexus impingement with loss of extremity function, we have selectively utilized a combination of imatinib and radiation therapy. Read More

    Myofibroblastic, fibroblastic and myoid lesions of the breast.
    Semin Diagn Pathol 2017 Sep 28;34(5):427-437. Epub 2017 May 28.
    Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
    Myofibroblastic, fibroblastic and/or myoid lesions are rare in the breast but comprise the majority of mammary mesenchymal spindle cell lesions. Whereas most have similar features to their counterparts at extramammary sites, pseudoangiomatous stromal hyperplasia is considered a breast-specific myofibroblastic proliferation on the same spectrum as myofibroblastoma. Other lesions with myofibroblastic/fibroblastic differentiation include fibromatosis and nodular fasciitis, as well as more aggressive tumors such as the rarely reported myofibrosarcoma, inflammatory myofibroblastic tumor and fibrosarcoma. Read More

    Cesarean section after abdominal mesh repair for pregnancy-related desmoid tumor: a case report.
    Int J Womens Health 2017 12;9:497-499. Epub 2017 Jul 12.
    Obstetrics and Gynaecology Department, Liverpool Hospital, Liverpool, NSW, Australia.
    We report the case of a 32-year-old gravida 2 para 1 woman with a background of partially resected desmoid tumor (DT) arising from the previous cesarean section (CS) scar. This case details the management of her DT by surgical resection and mesh repair and second pregnancy following this. Pregnancy-related DTs are a relatively rare entity, and there is a paucity of literature regarding their management during pregnancy. Read More

    Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: A nationwide prospective cohort from the French Sarcoma Group.
    Eur J Cancer 2017 Sep 20;83:125-131. Epub 2017 Jul 20.
    Centre Léon Bérard Lyon and Université Claude Bernard Lyon I, Lyon, France.
    Purpose: The outcome of desmoid-type fibromatosis (DTF) is unpredictable. Currently, a wait-and-see approach tends to replace large en bloc resection as the first therapeutic approach. Nevertheless, there are no validated factors to guide the treatment choice. Read More

    Gastroblastoma harbors a recurrent somatic MALAT1-GLI1 fusion gene.
    Mod Pathol 2017 Oct 21;30(10):1443-1452. Epub 2017 Jul 21.
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    Gastroblastoma is a rare distinctive biphasic tumor of the stomach. The molecular biology of gastroblastoma has not been studied, and no affirmative diagnostic markers have been developed. We retrieved two gastroblastomas from the consultation practices of the authors and performed transcriptome sequencing on formalin-fixed paraffin-embedded tissue. Read More

    Late toxicity and outcomes following radiation therapy for chest wall sarcomas in pediatric patients.
    Pract Radiat Oncol 2017 Nov - Dec;7(6):411-417. Epub 2017 Apr 26.
    Department of Radiation Oncology, St. Jude Children's Research Hospital Memphis, Tennessee.
    Purpose: To investigate the contribution of radiation therapy to acute and late toxicity in pediatric chest wall sarcoma patients and evaluate dosimetric correlates of higher incidence toxicities such as scoliosis and pneumonitis.

    Methods And Materials: The data from 23 consecutively treated pediatric patients with chest wall sarcomas of various histologies (desmoid, Ewing, rhabdomyosarcoma, nonrhabdomyosarcoma-soft tissue sarcomas) were reviewed to evaluate the relationship between end-organ radiation dose, clinical factors, and the risk of subsequent late effects (scoliosis, pneumonitis). Cobb angles were used to quantify the extent of scoliosis. Read More

    Desmoid Tumors in Familial Adenomatous Polyposis.
    Anticancer Res 2017 07;37(7):3357-3366
    Department of Internal Medicine and Clinical Oncology, Aldo Moro University of Bari, Bari, Italy
    Familial adenomatous polyposis (FAP) is a cancer syndrome caused by a germline mutation in the adenomatous polyposis coli (APC) gene. It is characterized by the presence of hundreds of colonic polyps, which have a high tendency to undergo malignant transformation. Among associated lesions in FAP, desmoid tumors represent a common possible life-threatening condition that requires special attention. Read More

    Mesenteric desmoid tumour presenting with recurrent abdominal abscess and duodenal fistula: A case report and review of literature.
    Int J Surg Case Rep 2017 16;37:119-123. Epub 2017 Jun 16.
    Department of Surgery, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, USA.
    Introduction: Desmoid tumors are locally destructive but histologically benign. Their management involves close observation and surgical, medical, or hormonal treatment.

    Presentation Of The Case: A 36-year-old male was admitted for abdominal pain and fever. Read More

    Embolization of a large progressive symptomatic desmoid tumor in the rectus muscle of a female patient with multiple sclerosis: a case report.
    Acta Chir Belg 2017 Jun 22:1-4. Epub 2017 Jun 22.
    a Department of General and Abdominal Surgery , ZNA Middelheim , Antwerp , Belgium.
    Introduction: Desmoid tumors are benign tumors, yet can lead to significant morbidity due to aggressive local expansions. Treatment starts with a wait-and-see policy, however, more aggressive treatments like broad margin resection surgery might be necessary in case of tumor progression.

    Patients And Methods: We report the case of a 26-year-old female with a symptomatic desmoid tumor in the left rectus muscle. Read More

    Fibroblastic connective tissue nevus: Clinicopathological and immunohistochemical study of 14 cases.
    J Cutan Pathol 2017 Oct 19;44(10):827-834. Epub 2017 Jul 19.
    Dermopathologie Bodensee, Friedrichshafen, Germany.
    Background: We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labeled as fibroblastic connective tissue nevus (FCTN).

    Methods And Results: Total of 8 patients were male and 5 were female, ranging in age from 1 to 56 years. Lesions appeared as isolated nodules or plaques on the trunk (7 cases), the limbs (4 cases) and the neck (2 cases). Read More

    Malignant tumours of the foot and ankle.
    EFORT Open Rev 2017 May 11;2(5):261-271. Epub 2017 May 11.
    Laboratoire d'anatomie et cytologie pathologiques, Institut Universitaire du Cancer de Toulouse- Oncopole, 1 avenue Irène Joliot-Curie. 31059 Toulouse Cedex 9, France.
    Most of tumours of the foot are tumour-like (synovial cyst, foreign body reactions and epidermal inclusion cyst) or benign conditions (tenosynovial giant cells tumours, planta fibromatosis). Malignant tumours of the soft-tissue and skeleton are very rare in the foot and their diagnosis is often delayed with referral to specialised teams after initial inappropriate procedures or unplanned excisions. The adverse effect of these misdiagnosed tumours is the increasing rate of amputation or local recurrences in the involved patients. Read More

    β-Catenin in desmoid-type fibromatosis: deep insights into the role of T41A and S45F mutations on protein structure and gene expression.
    Mol Oncol 2017 Nov 29;11(11):1495-1507. Epub 2017 Sep 29.
    Laboratory of Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
    Desmoid-type fibromatosis (DF) is a rare mesenchymal lesion with high risk of local recurrence. Specific β-catenin mutations (S45F) appeared to be related to this higher risk compared to T41A-mutated or wild-type (WT). We explored the influence of both mutations and WT on structure stability and affinity of β-catenin for α-catenin and the pattern of gene expression that may influence DF behavior. Read More

    Multi-parametric (mp) MRI for the diagnosis of abdominal wall desmoid tumors.
    Eur J Radiol 2017 Jul 17;92:103-110. Epub 2017 Apr 17.
    Department of Clinical Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada. Electronic address:
    Introduction: Desmoid tumors are benign myofibroblastic neoplasms, originating from the muscle aponeurosis and classified as deep fibromatoses. The aim of this study was to evaluate the utility of multi-parametric (mp)-MRI for the diagnosis of abdominal wall desmoid tumor (awdt).

    Material And Methods: This Institutional review board approved retrospective study compared 10 patients (mean age±SD; 38. Read More

    Sporadic giant intra-abdominal desmoid tumor: A radiological case report.
    Mol Clin Oncol 2017 Jun 8;6(6):896-898. Epub 2017 May 8.
    School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
    Desmoid tumor (DT) is a locally invasive form of fibromatosis, comprising only 0.03% of all tumors. DTs occur more frequently in patients with familial adenomatous polyposis and Gardner's syndrome, as intra-abdominal or anterior abdominal wall tumors, whereas sporadic DTs are more likely to be extra-abdominal (only 5% of sporadic DTs are intra-abdominal). Read More

    Desmoid Tumor of Rectus Abdominis Presenting with Grey-Turner's and Cullen's Sign: A Report of a Rare Case.
    Indian J Dermatol 2017 May-Jun;62(3):318-320
    Department of Dermatology, SVS Medical College, Mahbubnagar, Telangana, India.
    Desmoid tumor of rectus abdominis presenting with Grey-Turner's and Cullen's sign is rare. Herein, we report desmoid tumor of rectus abdominis in a 64-year-old multiparous female who presented with ecchymosis involving left flank and around the umbilicus. Histopathological examination of biopsy from the tumor confirmed the diagnosis of the desmoid tumor. Read More

    Biology and Treatment of Aggressive Fibromatosis or Desmoid Tumor.
    Mayo Clin Proc 2017 Jun;92(6):947-964
    Department of Medicine, University of Minnesota Medical School, Minneapolis. Electronic address:
    Aggressive fibromatosis, also known as desmoid-type fibromatosis (DTF) or desmoid tumor, is an uncommon locally invasive tumor. Because of its low incidence and variable behavior, DTF is often first seen by physicians who are not familiar with it, and recent advances in understanding this disease have led to changes in treatment approaches. The Wnt (β-catenin) pathway appears to play a key role in DTF pathogenesis, and recent studies of DTF biology suggest a possible model of DTF pathogenesis. Read More

    Comparison of sporadic and FAP-associated desmoid-type fibromatoses.
    J Surg Oncol 2017 Nov 1;116(6):716-721. Epub 2017 Jun 1.
    Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
    Background And Objectives: Desmoid-type fibromatosis is a rare disease of which 7.5-16% have been reported to be related to familial adenomatous polyposis (FAP). We sought to compare the characteristics and treatment of sporadic and FAP-related desmoid-type fibromatoses. Read More

    Chest wall reconstruction following axillary breast augmentation and desmoid tumor resection using capsular flaps and a form-stable silicone implant: A case report, diagnosis and surgical technique.
    Int J Surg Case Rep 2017 21;36:110-115. Epub 2017 May 21.
    University of São Paulo, São Paulo, Brazil.
    Introduction: Chest desmoid tumors (CDT) are rare lesions characterized by fibroblastic proliferation from the connective tissue. Although CDT have been studied previously, no cases following subfascial transaxillary breast augmentation (TBA) have been described.

    Presentation Of Case: The authors describe a case of CDT in a 28-year-old woman one year after TBA, which presented as a painful and progressive mass in the lower-inner right breast quadrant. Read More

    An Intra-Abdominal Desmoid Tumor, Embedded in the Pancreas, Preoperatively Diagnosed as an Extragastric Growing Gastrointestinal Stromal Tumor.
    Case Rep Oncol 2017 Jan-Apr;10(1):301-307. Epub 2017 Apr 4.
    aDepartment of Gastroenterology, Tokai University School of Medicine, Isehara, Japan.
    A 45-year-old woman was found to have a pancreatic tumor by abdominal ultrasound performed for a medical check-up. Abdominal contrast-enhanced computed tomography showed a hypovascular tumor measuring 30 mm in diameter in the pancreatic tail. Endoscopic ultrasound-guided fine needle aspiration was performed. Read More

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