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    1 OF 51

    Desmoid tumor following abdominally-based free flap breast reconstruction.
    Gland Surg 2017 Feb;6(1):89-92
    Division of Plastic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
    Desmoid tumors are fibroblastic connective tissue tumors that most commonly develop within the anterior abdominal wall. The etiology of desmoid tumors has not been well defined; however, hereditary, hormonal, traumatic, and surgery-related causes have been implicated. Desmoid tumors are believed to arise from musculoaponeurotic structures. Read More

    Sporadic desmoid tumors in the pediatric population: A single center experience and review of the literature.
    J Pediatr Surg 2017 Feb 4. Epub 2017 Feb 4.
    Department of Pediatric Hematology-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva 4941492, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address:
    Background/purpose: We present our long experience with desmoid tumors in children.

    Methods: Data were retrospectively collected from 17 children/adolescents treated for sporadic desmoid tumors at a tertiary pediatric hospital in 1988-2016. There were 10 girls and 7 boys aged 1-17years. Read More

    Meta-analysis of the influence of surgical margin and adjuvant radiotherapy on local recurrence after resection of sporadic desmoid-type fibromatosis.
    Br J Surg 2017 Mar;104(4):347-357
    Departments of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
    Background: Extra-abdominal desmoid-type fibromatosis (DF) is a rare, locally aggressive neoplasm that is usually managed conservatively. When treatment is indicated, it typically involves surgical resection, possibly with adjuvant radiotherapy. The indications for postoperative radiotherapy and its effectiveness are unclear. Read More

    MRgFUS for desmoid tumors within the thigh: early clinical experiences.
    J Ther Ultrasound 2017 3;5. Epub 2017 Feb 3.
    0000 0001 2297 6811grid.266102.1Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107-5705 USA.
    Background: Desmoid tumors are benign but locally aggressive non-malignant tumors derived from fibroblasts. Surgery, chemotherapy, and radiation therapy have been the mainstay of treatment, but recurrence is common and side effects can result in significant morbidity. In this case series, we highlight our experiences performing treatments in the thigh, including strategies for optimizing ablation size and safety. Read More

    Endoscopic Subtotal Fasciectomy of the Foot.
    Arthrosc Tech 2016 Dec 5;5(6):e1387-e1393. Epub 2016 Dec 5.
    Department of Orthopaedics and Traumatology, North District Hospital, Hong Kong SAR, China.
    Plantar fibromatosis is a rare benign but often locally aggressive tumor of the plantar aponeurosis. Nonsurgical treatment is the first line of treatment for symptomatic lesions. Because of the high recurrence rate associated with surgical treatment, operation is indicated only when the lesions are highly symptomatic and conservative measures fail or the diagnosis is in question. Read More

    [A Case of Familial Adenomatous Polyposis with a Desmoid Tumor Probably Communicating to the Intestinal Lumen That Was Successfully Treated with Non-Surgical Therapy].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2316-2319
    Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
    A 44-year-old man with familial adenomatous polyposis underwent laparoscopic-assistedtotal proctocolectomy with ilealpouch anal anastomosis(IPAA). Computed tomography conducted 21 months after IPAA demonstrated bilateral hydronephrosis andan intra-abdominal mass with a maximal diameter of 22 cm, leading to a diagnosis of stage IV desmoid disease, according to the classification by Church and associates. Six courses of combination chemotherapy with doxorubicin plus dacarbazine were administered. Read More

    Pazopanib, a promising option for the treatment of aggressive fibromatosis.
    Anticancer Drugs 2017 Jan 17. Epub 2017 Jan 17.
    aSarcoma Unit, The Royal Marsden Hospital NHS Foundation Trust, London bDepartment of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge cThe Institute of Cancer Research, Sutton, UK.
    Desmoid tumour/aggressive fibromatosis (DT/AF) is a rare soft-tissue neoplasm that is locally aggressive but does not metastasize. There is no standard systemic treatment for symptomatic patients, although a number of agents are used. Tyrosine kinase inhibitors have recently been reported to show useful activity. Read More

    TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevant Xenopus tropicalis tumor models.
    Genesis 2017 Jan;55(1-2)
    Developmental Biology Unit, Department of Biomedical Molecular Biology, Ghent University, Belgium.
    The targeted nuclease revolution (TALENs, CRISPR/Cas9) now allows Xenopus researchers to rapidly generate custom on-demand genetic knockout models. These novel methods to perform reverse genetics are unprecedented and are fueling a wide array of human disease models within the aquatic diploid model organism Xenopus tropicalis (X. tropicalis). Read More

    Radiotherapy in desmoid tumors : Treatment response, local control, and analysis of local failures.
    Strahlenther Onkol 2017 Jan 2. Epub 2017 Jan 2.
    Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, PO Box 180, 00029 HUS, Helsinki, Finland.
    Background: Desmoid tumors (aggressive fibromatosis) are rare soft tissue tumors which frequently recur after surgery. Desmoid tumors arise from musculoaponeurotic tissue in the extremities, head and neck, abdominal wall, or intra-abdominally. Our aim was to examine the outcome of radiotherapy of desmoid tumors in a single institution series. Read More

    Comparison of β-Catenin and LEF1 Immunohistochemical Stains in Desmoid-type Fibromatosis and its Selected Mimickers, With Unexpected Finding of LEF1 Positivity in Scars.
    Appl Immunohistochem Mol Morphol 2016 Dec 23. Epub 2016 Dec 23.
    Departments of *Department of Pathology †Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH.
    β-catenin immunohistochemical stain can be useful in the diagnosis of many tumors including desmoid-type fibromatosis (DTF). Lymphoid enhancer-factor 1 (LEF1), a recently emerged marker, is part of the Wnt pathway with β-catenin but has not been studied in DTF. We performed LEF1 and β-catenin immunohistochemistry in DTF (n=26), superficial fibromatosis (n=19), sclerosing mesenteritis (n=12), gastrointestinal stromal tumor (n=17), and cutaneous scar (n=14) using tissue microarray and whole sections. Read More

    Fibromatosis Associated With Neuromuscular Choristoma: Evaluation by FDG PET/CT.
    Clin Nucl Med 2017 Mar;42(3):e168-e170
    From the Departments of *Radiology, †Neurosurgery, and ‡Orthopedic Surgery, Mayo Clinic, Rochester, MN.
    Neuromuscular choristoma (NMC) is a rare benign peripheral nerve lesion consisting of mature skeletal muscle fibers admixed with nerve fascicles. Aggressive fibromatosis frequently develops in association with NMC, often after surgery or biopsy, but the exact pathogenesis is not known. We present a case of NMC complicated by aggressive fibromatosis evaluated by F-FDG PET/CT and examine the relationship of metabolic activity and MRI signal characteristics. Read More

    Desmoid Fibromatosis Presenting as Deep Venous Thrombosis: A Case Report and Discussion.
    Am J Case Rep 2016 Dec 20;17:967-972. Epub 2016 Dec 20.
    Department of Surgery, University of Adelaide, Adelaide, SA, Australia.
    BACKGROUND Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common, serious cardiovascular event. Predisposing factors include genetic disorders, immobility, and underlying malignancy. Soft tissue tumors are by contrast rare, but should be included in the differential etiology of DVT, especially when the patient is young and has few thrombotic risk factors. Read More

    Breast Desmoid Tumor after Ductal Carcinoma Treatment: Salvaging a DIEP Flap Reconstruction.
    Plast Reconstr Surg Glob Open 2016 Nov 23;4(11):e1142. Epub 2016 Nov 23.
    Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, Houston, Tex.; and College of Medicine, Texas A&M University College of Medicine, Houston, Tex.
    Supplemental Digital Content is available in the text. Read More

    Pazopanib: a novel treatment option for aggressive fibromatosis.
    Clin Sarcoma Res 2016 1;6:22. Epub 2016 Dec 1.
    Department of Medical Oncology, Ege University Medical School, Tulay Aktas Oncology Hospital, Ege University, Izmir, Turkey.
    Background: Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resection is well documented. No effective cytotoxic treatment has been reported, hence there is a need for novel treatment strategies. Read More

    Bilateral perirenal space fibromatosis with renal infiltration: case report and review of literature.
    Radiol Case Rep 2016 Dec 19;11(4):438-443. Epub 2016 Oct 19.
    Division of Imageology, Regional Cancer Centre, Room No 26 PACS Room, Trivandrum, Kerala 695011, India.
    Fibromatosis and/or desmoid tumors which constitute less than 1% of all neoplasms and 3.0% of all soft-tissue tumors are pathologically benign proliferations of the fibroblasts but are locally aggressive with infiltrative type of growth and tendency toward recurrence. Bilateral symmetrical perirenal involvement has been described in many conditions which can be renal, subcapsular, or perirenal in origin. Read More

    Liposomal doxorubicin: Effective treatment for pediatric desmoid fibromatosis.
    Pediatr Blood Cancer 2016 Dec 1. Epub 2016 Dec 1.
    Department of Pediatric Hematology/Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.
    Efficacy of liposomal doxorubicin (LD) in treating desmoid fibromatosis (DF) in children has not been well evaluated. This retrospective case series examines five children with progressive DF, treated with LD. We report progression-free intervals (PFIs) and radiographic as well as clinical responses for each medication received. Read More

    Desmoid Tumor of the Chest Wall Mimicking Recurrent Breast Cancer: Multimodality Imaging Findings.
    Iran J Radiol 2016 Oct 4;13(4):e31649. Epub 2016 Jul 4.
    Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    Desmoid tumor of breast is a rare benign, locally aggressive tumor with a high recurrence rate. It has been associated with scar from previous breast surgery or trauma. Especially in breast cancer patients with previous operation history, it may simulate recurrent breast cancer clinically and radiologically. Read More

    Primary mesenchymal tumors of the pancreas in a single center over 15 years.
    Oncol Lett 2016 Nov 20;12(5):4027-4034. Epub 2016 Sep 20.
    Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.
    In total, 95% of primary tumors in the pancreas are epithelial tumors; primary mesenchymal tumors at this site are extremely rare. At present, only one comprehensive study about these rare tumors has been performed. Another retrospective analysis of these rare tumors is performed in the present study, which, to the best of our knowledge, is the first to be performed in China. Read More

    Desmoid Tumours in Familial Adenomatous Polyposis: Review of 17 Patients from a Portuguese Tertiary Center.
    J Clin Diagn Res 2016 Oct 1;10(10):PC01-PC05. Epub 2016 Oct 1.
    General Surgeons, Department of Surgery, General Surgery Service, Centro Hospitalar do Porto , Largo Prof. Abel Salazar, 4099-001, Porto, Portugal .
    Introduction: Desmoid Tumours (DT) are benign tumours with an estimated incidence of 2-4 per million per year. Between 7-16% of them are associated with Familial Adenomatous Polyposis (FAP) and are mostly parietal or intra-abdominal. They are a challenge in relation to their unpredictable natural course, associated complications and difficult treatment. Read More

    UK guidelines for the management of soft tissue sarcomas.
    Clin Sarcoma Res 2016 15;6:20. Epub 2016 Nov 15.
    Royal Marsden NHS Foundation Trust, London, SW3 6JJ UK.
    Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence-based guidelines is complicated by the limitations of the data available. However, this makes it more important that STS are managed by teams, expert in such cases, to ensure consistent and optimal treatment, as well as recruitment to clinical trials, and the ongoing accumulation of further data and knowledge. Read More

    Desmoplastic fibroma of the distal tibia: A case report of a minimally invasive histological diagnosis.
    Mol Clin Oncol 2016 Nov 19;5(5):537-539. Epub 2016 Sep 19.
    Department of Diagnostic Imaging, Arcispedale Santa Maria Nuova-IRCCS, I-42100 Reggio Emilia, Italy.
    Desmoplastic fibroma (DF) is a benign, rare fibroblastic intraosseous neoplasm histologically resembling a desmoid soft tissue tumor. Although classified as benign, DF frequently exhibits an aggressive behavior, has a moderate-to-high recurrence rate, and often causes pathological fractures and extensive bone destruction. This case report presents an incidentally detected DF of the tibia, which was diagnosed using a minimally invasive approach. Read More

    Iodine-125 Interstitial Brachytherapy for Pediatric Desmoid-Type Fibromatosis of the Head and Neck: A Case Report.
    J Oral Maxillofac Surg 2016 Oct 29. Epub 2016 Oct 29.
    Professor, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China. Electronic address:
    Desmoid-type fibromatosis (DF) is a locally aggressive benign soft tissue tumor. It is rarely observed in the head and neck region and is particularly uncommon in the parotid gland. This report describes the case of a 32-month-old girl with DF of the head and neck. Read More

    Increasing Role of Image-Guided Ablation in the Treatment of Musculoskeletal Tumors.
    Cancer J 2016 Nov/Dec;22(6):401-410
    From the Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN.
    In the last decade, percutaneous treatment of musculoskeletal (MSK) tumors has become more established in routine clinical care while also undergoing a number of advancements. Ablative techniques to palliate painful skeletal metastases have gained wide acceptance, while goals for ablation have evolved to include local control of oligometastases and desmoid tumors. Bone consolidation or augmentation is now frequently used in conjunction with or instead of ablation of skeletal tumors to stabilize pathologic fractures or prevent further morbidity that could result from fractures caused by tumor progression. Read More

    Management strategies in Lynch syndrome and familial adenomatous polyposis: a national healthcare survey in Japan.
    Cancer Sci 2016 Nov 21. Epub 2016 Nov 21.
    Tokyo Medical and Dental University, Tokyo, Japan.
    Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are major sources of hereditary colorectal cancer (CRC) and associated with other malignancies. There is some heterogeneity in management strategies in Japan. We performed a survey of management of hereditary CRC in hospitals that are members of the Japan Society of Colorectal Cancer Research (JSCCR). Read More

    A case of thyroid fibromatosis, a rare lesion of this gland.
    Endocrinol Diabetes Metab Case Rep 2016 11;2016. Epub 2016 Oct 11.
    Serviço de Endocrinologia; Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal; NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
    : Thyroid fibromatosis is a very rare lesion; to our knowledge, there are only four cases reported in the medical literature. Herein, we report the clinical case of a woman with thyroid fibromatosis with a long follow-up (11 years). A 63-year-old female patient, with an increasing multinodular goitre without compressive symptoms, was admitted to total thyroidectomy. Read More

    Does routine colonoscopy help diagnose familial adenomatous polyposis in patients presenting with desmoid tumors but no gastrointestinal symptoms?
    Int J Colorectal Dis 2017 Jan 14;32(1):151-154. Epub 2016 Nov 14.
    Department of Surgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, 13620, South Korea.
    Purpose: Desmoid tumor (DT) is a rare myofibroblastic proliferative neoplasm, but can occur in up to 26% of patients with familial adenomatous polyposis (FAP). Therefore, DT may be an extraintestinal manifestation of FAP that precedes the development of advanced malignancies. The aim of this study was to identify the incidence of polyps in DT patients and investigate value of colonoscopy for diagnosis of FAP in DT patients without gastrointestinal symptoms. Read More

    Cytohistological and immunohistochemical characteristics of spindle-shaped mesenchymal neoplasms occurring in the gastrointestinal tract.
    Scand J Gastroenterol 2017 Mar 6;52(3):291-299. Epub 2016 Nov 6.
    a Department of Human Pathology of adult and evolutive age "Gaetano Barresi" , University of Messina, A.O.U. "Policlinico G.Martino" , Messina , Italy.
    The purpose of the present review is to analyze the cytohistological and immunohistochemical characteristics of spindle-shaped mesenchymal gastrointestinal neoplams (MGNs), a group of unusual neoplastic conditions with different biological behavior. These tumors exhibit clinical pictures strictly related to the site of origin and dimensions, even if they appear generally with an intramural localization. This latter point may suggest an useful application of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), mainly followed by the cell-block procedure (CBP) in the differential diagnostic approach. Read More

    Rapid progression of a pregnancy-associated intra-abdominal desmoid tumor in the post-partum period: A case report.
    Int J Surg Case Rep 2016 26;29:30-33. Epub 2016 Oct 26.
    Department of Surgery, Division of General and Oncologic Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States. Electronic address:
    Introduction: The clinical behavior of desmoid tumors can be unpredictable, particularly when they arise in the ante-partum or post-partum period. We present a case of an intra-abdominal desmoid tumor that was identified in the ante-partum period, progressed rapidly in the post-partum period, and was subsequently resected.

    Presentation Of Case: The patient is a 19 year-old female who was found to have a 12cm intra-abdominal mass on a fetal assessment ultrasound. Read More

    Sporadic desmoid tumors of the abdominal wall: the results of surgery.
    Tumori 2016 Dec 3;102(6):582-587. Epub 2016 Sep 3.
    Department of Surgical Oncology, Humanitas Clinical and Research Center, Milan - Italy.
    Purpose: Before the wait-and-see policy became the standard approach in abdominal wall desmoid tumors, surgery was performed on a systematic basis. Surgery remains indicated for progressing tumors but its extent is debatable. The abdominal wall is a common site of origin of sporadic desmoids, usually associated with a favorable prognosis. Read More

    Low-grade Nonrhabdomyosarcoma Soft Tissue Sarcoma: What is Peculiar for Childhood.
    J Pediatr Hematol Oncol 2016 Nov;38(8):615-621
    Departments of *Pediatric Oncology §Surgical Oncology, National Cancer Institute, Cairo University †Department of Pediatric Oncology, Children Cancer Hospital ‡Department of Pediatrics, National Research Center ∥Department of Pediatrics, Misr Insurance Hospital, Cairo, Egypt.
    Background: Nearly half of soft tissue sarcomas are nonrhabdomyosarcomas (NRSTSs). The low-grade (LG) form comprises a heterogenous group of diseases that rarely metastasize but are known for local recurrence.

    Aim Of The Study: The aim of the study was to retrospectively evaluate pediatric LG-NRSTS with regard to demography, survival, and factors affecting outcome in Egyptian patients. Read More

    Long-term outcomes of 47 patients with aggressive fibromatosis of the chest treated with surgery.
    Eur J Surg Oncol 2016 Nov 29;42(11):1693-1698. Epub 2016 Jun 29.
    Department of Pathology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing, 100730, China.
    Aims: The purpose of the study was to review a large series of chest aggressive fibromatosis (AF) cases with an emphasis on the outcomes of different degrees of resection and the value of postoperative radiotherapy.

    Materials And Methods: The records of patients with chest AF treated at our hospital from 1982 to 2014 were retrospectively reviewed. Recurrence rates and non-disease survival (NDS) times were compared between the R0, R1, and R2 resection groups. Read More

    Free fillet flap application to cover forequarter or traumatic amputation of an upper extremity: A case report.
    Microsurgery 2016 Nov 20;36(8):700-704. Epub 2016 Oct 20.
    Department of Plastic and Hand Surgery, University Hospital Zurich, Switzerland.
    Reusing tissue of amputated or unsalvageable limbs to reconstruct soft tissue defects is one aspect of the "spare parts concept." Using a free fillet flap in such situations enables the successful formation of a proximal stump with the length needed to cover a large defect from forequarter amputation without risking additional donor-site morbidity. The use of free fillet flaps for reconstruction after forequarter and traumatic upper extremity amputations is illustrated here in a case report. Read More

    The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.
    Eur J Cancer 2016 Nov 14;68:114-124. Epub 2016 Oct 14.
    Department of Pathology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:
    Introduction: S100a4 is a calcium-binding protein belonging to the family of S100-proteins, highly expressed in different stromal cell types. S100A4 has been reported as a prognostic marker in colorectal cancer in association with tumour progression and metastasis.

    Methods: In this study, we analysed the in vivo role of S100a4 in intestinal tumour initiation and progression using different transgenic and knockout mouse models. Read More

    Sacrificing the internal carotid artery in infiltrating neck tumours: a study of four clinical cases.
    Int J Oral Maxillofac Surg 2017 Jan 10;46(1):11-15. Epub 2016 Oct 10.
    Department of Maxillofacial and Plastic Surgery, Faculty of Dentistry, Alexandria University, Alexandria, Egypt. Electronic address:
    Tumour infiltration of the carotid arteries, especially the common carotid artery (CCA) and the internal carotid artery (ICA), is a great challenge in maxillofacial surgery. Cases in which the malignant tumour and/or lymph node is stuck to the carotid artery, especially the ICA, have previously been considered inoperable. Four such cases, two with recurrent metastatic nodal neck masses encasing the ICA, one with aggressive fibromatosis, and one with a carotid body tumour, are described herein. Read More

    Papillary thyroid carcinoma with nodular fasciitis-like stroma and β-catenin mutations should be renamed papillary thyroid carcinoma with desmoid-type fibromatosis.
    Mod Pathol 2017 Feb 7;30(2):236-245. Epub 2016 Oct 7.
    Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
    Various histological variants of papillary thyroid carcinoma have been reported, some with clinical implications, some with peculiar, sometimes misleading morphologies. One of these rare and poorly characterized variants is papillary thyroid carcinoma with nodular fasciitis-like stroma, of which fewer than 30 cases have been documented, mostly as isolated reports. It is a dual tumor comprising a malignant epithelial proliferation that harbors typical features of conventional papillary thyroid carcinoma, admixed with a prominent mesenchymal proliferation resembling nodular fasciitis or fibromatosis. Read More

    Recurrent giant cranial desmoid tumor in a 3-year-old boy with familial adenomatous polyposis requiring bifrontoparietal cranioplasty: case report.
    J Neurosurg Pediatr 2016 Dec 16;25(6):703-707. Epub 2016 Sep 16.
    Departments of 1 Neurological Surgery and.
    Desmoid tumors, also known as aggressive fibromatosis, are locally infiltrating musculoaponeurotic neoplasms arising in connective tissues. Desmoid tumors may be associated with familial adenomatous polyposis (FAP), a genetic disorder that presents with hundreds to thousands of precancerous colorectal polyps. The authors report the case of an 18-month-old boy who underwent resection of a right temporal desmoid tumor (initially diagnosed as cranial fasciitis) and developed a bilateral frontoparietal calvarial desmoid tumor 2 years later. Read More

    Carbon ion radiotherapy for desmoid tumor of the abdominal wall: a case report.
    World J Surg Oncol 2016 Sep 13;14(1):245. Epub 2016 Sep 13.
    Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi, Yoshida, Sakyoku, Kyoto, 606-8501, Japan.
    Background: Desmoid tumors, which are associated with familial adenomatous polyposis (FAP), tend to occur frequently in the abdominal wall and mesentery. Currently, there are no recognized treatments other than surgery, and frequent surgeries result in gastrointestinal obstructions and functional gastrointestinal disorders.

    Case Presentation: After surgery that was performed on a 39-year-old patient with FAP, we performed a second tumor excision which was the procedure used for frequently occurring mesenteric desmoid tumors. Read More

    Conservative management of desmoid tumors is safe and effective.
    J Surg Res 2016 Sep 16;205(1):115-20. Epub 2016 Jun 16.
    Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California. Electronic address:
    Background: Surgical resection of desmoid tumors has traditionally been the mainstay of therapy, but this is a potentially morbid approach with high rates of recurrence. Given increasing reports of active surveillance in this disease, we sought to evaluate our experience with conservative management hypothesizing this would be an effective strategy.

    Materials And Methods: Using a prospectively maintained database of sarcoma patients from 2008 to 2015, we identified 47 patients with a diagnosis of desmoid tumor from all anatomic sites. Read More

    Surgical Management of Desmoid Tumor of the Female Pelvis: A Case Report.
    Mymensingh Med J 2016 Jul;25(3):580-4
    Dr Shirin Akter Begum, Associate Professor, Obs & Gyne, Bangabandhu sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh; E-mail: shirin.bsmmu@
    A 25 years married women having one child delivered vaginaly presented in the department of Obs & Gynae, Bangabandhu Sheikh Mujib Medical University, Bangladesh on April 2013 with pelvic pain and discomfort. No history of previous pelvic trauma was present. Patient examination showed a isolated mass in the right lower abdomen, right adnexa, extending to the pelvic wall upto lower end of ureter. Read More

    Desmoid-type fibromatosis of the breast: A case report.
    Breast Dis 2016 ;36(4):149-152
    Desmoid-type fibromatosis of the breast (also referred to as desmoid tumor or aggressive fibromatosis) is exceedingly rare. Although it does not metastasize, desmoid-type fibromatosisis is frequently locally aggressive. Recurrence is common (up to 35%), even after presumed total excision of the primary tumor [1]. Read More

    Desmoid-Type Fibromatosis: Evolving Treatment Standards.
    Surg Oncol Clin N Am 2016 Oct 5;25(4):803-26. Epub 2016 Aug 5.
    Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, Milan 20133, Italy.
    Desmoid-type fibromatosis is a rare nonmetastasizing neoplasm with variable behavior. Recent discoveries into the biology of this disease hold promise for identifying prognostic and predictive features and novel therapeutic targets. Surgery has been the historical standard of care but carries considerable drawbacks in terms of high local recurrence rates and poor functional outcomes. Read More

    Bilateral desmoid tumor of the breast: case seriesand literature review.
    Int Med Case Rep J 2016 22;9:247-51. Epub 2016 Aug 22.
    Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Background: Desmoid tumor of the breast is very rare and locally aggressive but has no distant metastasis. Bilateral lesions are extremely rare, found in only 4% of patients. Two cases of bilateral desmoid tumor of the breast are reported. Read More

    A Sporadic Desmoid Tumor: an Exceptional Pancreatic Cystic-Solid Mass.
    Indian J Surg 2016 Aug 13;78(4):318-20. Epub 2015 Nov 13.
    Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran.
    Desmoid tumors are locally aggressive and non-metastatic neoplasms with a high rate of recurrence. Desmoid tumors of the pancreas are, however, very rare, and only a few cases have been reported in the literature. This paper reports an anecdotal case of a diffuse pancreatic desmoid tumor with the involvement of the pancreatic head, body, and-partially-tail. Read More

    Tailored Beta-catenin mutational approach in extra-abdominal sporadic desmoid tumor patients without therapeutic intervention.
    BMC Cancer 2016 Aug 26;16:686. Epub 2016 Aug 26.
    Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
    Background: The efficacy of the classical treatment modalities surgery and radiotherapy in the treatment of aggressive fibromatosis is presently disputed and there is a shift towards a more conservative approach. The aim of the present study is to objectify tumor growth in patients with extra-abdominal or abdominal wall aggressive fibromatosis, while adhering to a "watchful waiting" policy. Other objectives are to investigate quality of life and to identify factors associated with tumor growth, in particular the relation with the presence of a CTNNB1-gene mutation in the tumor. Read More

    Management of Desmoids.
    Surg Clin North Am 2016 Oct;96(5):1015-30
    Division of Surgical Oncology, Department of Surgery, The Ohio State University, N924 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address:
    Desmoid tumors are rare, comprising 3% of soft tissue tumors. Surgical resection has been the standard of care; however, this has begun to evolve into a movement of watchful waiting as observational studies have shown long-term stability of many tumors without treatment and even spontaneous regression in 5% to 10% of cases. When surgical therapy is used, wide local excision with microscopically negative margins is the goal of resection but should not be at the expense of organ or limb function. Read More

    Management of Truncal Sarcoma.
    Surg Clin North Am 2016 Oct;96(5):1003-13
    Sarcoma Department, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33606, USA. Electronic address:
    The management of truncal sarcoma presents unique challenges to the treating physician for reasons specific to this tumor location. First, the reconstruction options after resection of the abdominal or chest wall require a balance between cosmesis and structural integrity due to the multiplanar forces exerted on this region. Second, the histologies that commonly arise in this region are often associated with high local recurrence rates, which often require complex decision making due to prior therapy. Read More

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