3,285 results match your criteria Desmoid Tumor


Extra-abdominal desmoid fibromatosis: Cryoablation versus traditional therapies.

Clin Imaging 2022 May 5;88:9-16. Epub 2022 May 5.

Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA.

Purpose: To retrospectively review the various methods used to treat extra-abdominal desmoid fibromatosis (EDF) at our institution to compare treatment response and complications with those for the emerging option of percutaneous cryoablation therapy.

Methods: A single-center retrospective review was conducted to identify patients with EDF who underwent some form of treatment for EDF in any combination (including medical therapy, surgery, percutaneous ablation and radiation therapy) at our institution between January 2007 and January 2020. Patients with pathological evidence of EDF and pretreatment and posttreatment images were included. Read More

View Article and Full-Text PDF

Consideration of rare postoperative complications of intestinal perforation in retroperitoneal aggressive fibromatosis.

Asian J Surg 2022 May 6. Epub 2022 May 6.

Department of Robotic Minimally Invasive Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, 610072, China. Electronic address:

View Article and Full-Text PDF

Pregnancy-associated large pelvic desmoid tumor: A case report of fetal-protective strategies and fertility preservation.

Gynecol Oncol Rep 2022 Feb 14;39:100901. Epub 2021 Dec 14.

Department of Ob/Gyn & Reproductive Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.

•Desmoid fibromatoses grow rapidly during the high estrogen-state of pregnancy.•Mass effect on the bladder is a complication of abdominal desmoid fibromatoses.•Cryoablation, doxorubicin, and post-partum prolactin are fetal-protective treatments. Read More

View Article and Full-Text PDF
February 2022

Desmoid tumors located in the abdomen or associated with adenomatous polyposis: French intergroup clinical practice guidelines for diagnosis, treatment, and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, SFR).

Dig Liver Dis 2022 May 1. Epub 2022 May 1.

Department of Digestive Oncology, CHU Reims, Reims, France.

Introduction: Desmoid tumor (DT) of the abdomen is a challenging and rare disease. The level of evidence available to document their treatment is relatively low, however, recent publications of prospective studies have allowed to precise their management.

Methods: This document is a summary of the French intergroup guidelines realized by all French medical and surgical societies involved in the management of DT located in the abdomen or associated with adenomatous polyposis. Read More

View Article and Full-Text PDF

Don't burn the blanket to kill a flea: A case of intra-abdominal desmoid fibromatosis.

Rev Esp Enferm Dig 2022 Apr 29. Epub 2022 Apr 29.

Pathology, AZ Delta Campus Rumbeke.

A 39-year-old woman presented to the Emergency Department with dysuria and persistent abdominal pain for several weeks. The pain increased with palpation. Physical examination was otherwise normal. Read More

View Article and Full-Text PDF

Surgical Management of a Giant Desmoid Fibromatosis of Abdominal Wall With Vessels Invasion in a Young Man: A Case Report and Review of the Literature.

Front Surg 2022 11;9:851164. Epub 2022 Apr 11.

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Background: Desmoid fibromatosis (DF) is a rare clonal proliferation of fibroblasts and myofibroblasts. It develops in the connective tissues and does not metastasize but may infiltrate adjacent structures. Because of the rarity of these tumors and the unpredictable natural history of the disease, well-defined and precise guidelines of the optimal treatment for DF have not been formulated. Read More

View Article and Full-Text PDF

Aggressive fibromatosis in the submandibular region of a child.

Clin Case Rep 2022 Apr 20;10(4):e05761. Epub 2022 Apr 20.

Department of Oral and Maxillofacial Radiology School of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran.

Aggressive fibromatosis is proliferation of well-differentiated fibroblasts. Submandibular region is rare location for fibromatosis. We report a case of a rapidly growing mass in submandibular region of 5-year-old girl, excised surgically and ascertained to be aggressive fibromatosis on histological examination. Read More

View Article and Full-Text PDF

Treatment of Orbital Desmoid-type Fibromatosis With Sorafenib.

Ophthalmic Plast Reconstr Surg 2022 Apr 25. Epub 2022 Apr 25.

Oculoplastic, Facial Cosmetic, and Orbital Surgery, Department of Ophthalmology and Visual Sciences.

Desmoid-type fibromatosis is a rare tumor, particularly in the orbit, with fewer than 10 cases of primary orbital desmoid-type fibromatosis reported in the literature. The authors present a case of an infant who presented with rapid onset of OD proptosis, disc edema, and hyperopic shift who was found to have a retrobulbar desmoid-type fibromatosis. After initial biopsy, due to risk of vision loss with complete excision, the tumor was treated with sorafenib, a tyrosine kinase inhibitor. Read More

View Article and Full-Text PDF

Current management and recent progress in desmoid tumors.

Cancer Treat Res Commun 2022 16;31:100562. Epub 2022 Apr 16.

Department of Medicine (Oncology), Stanford University School of Medicine, 875 Blake Wilbur Drive, Stanford, CA, 94305, USA. Electronic address:

Desmoid tumors are rare soft tissue tumors that can have aggressive infiltrative growth and relapse locally. Desmoid tumors can impact functionality and cause treatment-related morbidity and mortality. Here, the authors review current management strategies and avenues for further investigation. Read More

View Article and Full-Text PDF

Molecular Pathogenesis of Sporadic Desmoid Tumours and Its Implications for Novel Therapies: A Systematised Narrative Review.

Target Oncol 2022 Apr 21. Epub 2022 Apr 21.

Department of Surgery, The University of Melbourne, Melbourne, VIC, Australia.

Sporadic desmoid-type fibromatosis is a rare, fibroblastic soft-tissue neoplasm with local aggressiveness but no metastatic potential. Aberrant Wnt/β-catenin signalling has been extensively linked to desmoid pathogenesis, although little is known about other molecular drivers and no established treatment approach exists. We aimed to summarise the current literature regarding the molecular pathogenesis of sporadic desmoid-type fibromatosis and to discuss the effects of both current and emerging novel therapies targeting these mechanisms. Read More

View Article and Full-Text PDF

Transarterial Chemoembolization with Doxorubicin Eluting Beads for Extra-Abdominal Desmoid Tumors: Initial Experience.

Cardiovasc Intervent Radiol 2022 Apr 19. Epub 2022 Apr 19.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Purpose: To evaluate the feasibility, efficacy, and safety of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) as an alternative local treatment for extra-abdominal desmoid tumors (DTs).

Methods: Eleven adult female patients (mean age = 40.1 years) with symptomatic, progressively enlarging extra-abdominal DTs were determined ineligible for cryoablation after failing observation or systemic therapy and treated with a single session doxorubicin DEB-TACE. Read More

View Article and Full-Text PDF

Misdiagnosed desmoid fibromatosis of the chest wall presenting in emergency like as recurrence of post-traumatic hematoma: A case report and review of the literature.

Int J Surg Case Rep 2022 Apr 4;94:107019. Epub 2022 Apr 4.

General and Emergency Surgery Department, Garibaldi Hospital, Piazza Santa Maria di Gesù 5, 95124 Catania, Italy.

Introduction And Importance: Desmoid Fibromatosis (DF) represents a rare neoplasm developing from fascial and musculoaponeurotic structures. Preoperative diagnosis of DF is a challenge because of its rarity and nonspecific presentation. Imaging may be helpful for determining the correct diagnosis. Read More

View Article and Full-Text PDF

Parasitic leiomyoma in the trocar site after laparoscopic myomectomy: A case report.

World J Clin Cases 2022 Mar;10(9):2895-2900

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea.

Background: Laparoscopic myomectomy is increasingly used for resecting gynecological tumors. Leiomyomas require morcellation for retrieval from the peritoneal cavity. However, morcellated fragments may implant on the peritoneal cavity during retrieval. Read More

View Article and Full-Text PDF

Prognostic factors of abdominal desmoid tumor fibromatosis after surgery: A retrospective study of 52 patients.

Asian J Surg 2022 Apr 9. Epub 2022 Apr 9.

Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address:

View Article and Full-Text PDF

The Clinical Features of Multicentric Extra-abdominal Desmoid Tumors.

Cancer Diagn Progn 2021 Sep-Oct;1(4):339-343. Epub 2021 Jul 3.

Department of Orthopedic Oncology,The Cancer Institute Hospital of The Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: Extra-abdominal desmoid tumors often occur in the necks, shoulder, chest wall, back, arm, buttock, thigh and leg. Multicentric extra-abdominal desmoids are rather rare and seem to have other clinical features. The aim of our study was to investigate clinical features, especially multicentric occurrence of extra-abdominal desmoid tumors. Read More

View Article and Full-Text PDF

Case Report: Tyrosine Kinase Inhibitors Induced Lymphadenopathy in Desmoid Tumor Patients.

Front Endocrinol (Lausanne) 2022 23;13:794512. Epub 2022 Mar 23.

Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Tyrosine kinase inhibitors (TKIs) are nowadays a valuable treatment of desmoid tumors, a rare mesenchymal neoplasm. Although many side effects of imatinib and pazopanib, commonly or rarely occurring, have been described, reactional lymphadenopathy has not yet been reported. In this publication, we report two cases of patients with desmoid tumors, treated with pazopanib and imatinib, who developed reactional lymphadenopathy. Read More

View Article and Full-Text PDF

Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial.

J Clin Oncol 2022 Apr 8:JCO2101829. Epub 2022 Apr 8.

Mannheim University Medical Center, Mannheim, Germany.

Purpose: Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents.

Methods: SEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Read More

View Article and Full-Text PDF

Abdominal wall endometriosis misdiagnosed as a desmoid tumor: A case report.

Int J Surg Case Rep 2022 Apr 29;93:106979. Epub 2022 Mar 29.

Department of Surgery, General and Oncologic Surgery Unit, Santa Croce e Carle Hospital, Via M. Coppino 26, 12100 Cuneo, Italy. Electronic address:

Introduction: Abdominal wall masses have different aetiologies. Diagnosis includes desmoid tumors (DTs) and other benign and malignant lesions, among which abdominal wall endometriosis (AWE). Diagnosis is challenging if symptoms are aspecific, and the contribution of imaging may be weak. Read More

View Article and Full-Text PDF

Spontaneous Regression of Metachronous Intra-Abdominal Desmoid Tumor in a Patient with Familial Adenomatous Polyposis.

Case Rep Oncol 2022 Jan-Apr;15(1):71-77. Epub 2022 Feb 7.

Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Desmoid tumors are clonal fibroblastic neoplasms that arise in soft tissues. Patients with familial adenomatous polyposis (FAP) can develop intra-abdominal desmoid tumors. However, metachronous appearance of intra-abdominal desmoid tumor is rare, and its clinical course is not well known. Read More

View Article and Full-Text PDF
February 2022

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Familial Tumor Syndromes.

Head Neck Pathol 2022 Mar 21;16(1):143-157. Epub 2022 Mar 21.

MD Anderson Cancer Center, Houston, TX, USA.

The initiative of the 5th edition of the WHO classification of the Head and Neck Tumours establishing a new section dedicated to familial/heritable tumor syndromes with tumors and lesions in the head and neck region was much needed to better understand the tumours, diseases, and associated syndromes, as well as establish recommendations for monitoring and treating these patients. (WHO Classification of Tumours Editorial Board. Head and Neck tumours. Read More

View Article and Full-Text PDF

Aggressive fibromatosis in a child: a diagnostic challenge.

Pathology 2022 Mar 17. Epub 2022 Mar 17.

Eye Center, Medical Center - University of Freiburg, Freiburg, Germany.

View Article and Full-Text PDF

Lack of prognostic value of CTNNB1 mutation profile in desmoid-type fibromatosis.

Clin Cancer Res 2022 Mar 16. Epub 2022 Mar 16.

Gustave Roussy Cancer Institute, Villejuif, France.

Purpose: This prospective nationwide cohort study aimed to investigate desmoid-type fibromatosis (DF) outcomes, focusing on the prognostic value of CTNNB1 mutations.

Experimental Design: ALTITUDES (NCT02867033) was a nationwide prospective cohort study of DF diagnosed between January 2016 and December 2020. At diagnosis, CTNNB1 molecular alterations were identified using next-generation sequencing or Sanger sequencing. Read More

View Article and Full-Text PDF

Thoracic Epidural Analgesia Use in Large Recurrent Desmoid Fibromatosis Resection: A Case Report.

J Pain Palliat Care Pharmacother 2022 Mar 15;36(1):55-58. Epub 2022 Mar 15.

We present a case report of the successful use of thoracic epidural analgesia for the surgical resection of a large recurrent desmoid tumor and forequarter amputation in an adolescent male. Spinal anesthesia has been reported for intra-operative management of desmoid tumor resection, however, there are no reported cases of thoracic epidural analgesia for this tumor. Thoracic epidural should be used with caution in this patient population due to risk of de novo tumor creation but can be useful adjuvant to multi-modal analgesia to decrease post-operative opioid requirement. Read More

View Article and Full-Text PDF

The efficacy of low-power cumulative high-intensity focused ultrasound treatment for recurrent desmoid tumor.

Cancer Med 2022 Mar 11. Epub 2022 Mar 11.

Department of Medical Oncology, Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Background: Desmoid tumors are rare neoplasms that are locally invasive. However, optimal treatment strategies for recurrent desmoid tumors remain controversial. High-intensity focused ultrasound (HIFU) has been reported as a noninvasive modality for treating recurrent desmoid tumors. Read More

View Article and Full-Text PDF

Recent trends in the morbidity and mortality in patients with familial adenomatous polyposis: a retrospective single institutional study in Japan.

Int J Clin Oncol 2022 Mar 11. Epub 2022 Mar 11.

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.

Background: This study aimed to assess current trends in morbidity and mortality among patients with familial adenomatous polyposis (FAP). These data can be used for optimal surveillance and management of such patients.

Methods: Data (November 2001 and April 2020) of genetically confirmed patients with FAP (n = 87) and their first-degree relatives with FAP phenotype (n = 20) were extracted from the Saitama Medical Center database. Read More

View Article and Full-Text PDF

Desmoid Tumors Arising on the Mesenteric Surgical Scar of Abdominal Sarcomas.

Cureus 2022 Jan 30;14(1):e21727. Epub 2022 Jan 30.

Surgery, Institut Curie, Paris Sciences et Lettres (PSL) University, Paris, FRA.

A sporadic desmoid tumor (DT) is a rare type of tumor of the mesenchymal connective tissues is now considered an intermediate disease or locally aggressive. They may develop on scars or after traumatism, favored by growth factors released during the initial phase of wound healing. Most of the abdominal DT arising on a scar is described on the wall incision. Read More

View Article and Full-Text PDF
January 2022

Case report of recurrent fibromatosis with laryngeal involvement: Treatment based on network analyses of NGS data.

Mol Clin Oncol 2022 Mar 1;16(3):73. Epub 2022 Feb 1.

Department of Surgery, Division of Heme/Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Aggressive fibromatosis (AF) is a rare, benign neoplasm originating from musculoaponeurotic stromal structures characterized by aggressive growth and infiltration of local tissues. To date, only six previous cases of AF involving the larynx have been reported. The present case was that of a 70-year-old female patient with a 5-year history of hoarseness and an enlarging neck mass consistent with aggressive recurrent fibromatosis. Read More

View Article and Full-Text PDF

[A Case of Intra-Abdominal Desmoid Tumor after Laparoscopic Resection of Colon Cancer].

Gan To Kagaku Ryoho 2022 Feb;49(2):217-219

Dept. of Surgery, Kurobe City Hospital.

An 84-year-old man underwent laparoscopic descending colon resection for colon cancer with stage Ⅰ. Follow-up computed tomography(CT), 18 months after surgery showed a soft tissue density nodular mass, 30 mm in size, in the small intestinal mesentery. The surgical resection of the tumor was performed after a thorough examination. Read More

View Article and Full-Text PDF
February 2022