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Dermatology 2021 Jun 7:1-6. Epub 2021 Jun 7.

First Department of Dermatology, School of Medicine, Faculty of Health Sciences, Aristotle University, Thessaloniki, Greece.

Background: Blue color in dermoscopy can be seen in a wide range of benign and malignant lesions, melanocytic or not. Some blue-colored dermoscopic criteria have been associated with specific tumors, such as blue-white veil with melanoma and homogeneous blue with blue nevi. However, when blue color occupies a large part of the lesion's surface, the dermoscopic assessment might be particularly challenging. Read More

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):118-120

Department of Dermatology & STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

Eccrine hidrocystomas (EHs) are benign tumors, which arise as cystic dilatation of the eccrine sweat duct. The lesions of EH have a chronic course with periodic flares in summer months, associated with exacerbation in sweating. Diagnosis is mainly clinical with histopathology being confirmatory. Read More

J Dermatol Sci 2021 May 2. Epub 2021 May 2.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Ultra high-frequency ultrasound (uHFUS) is a recently developed diagnostic technology. Despite its potential usefulness, no study has assessed its advantage in diagnosis and evaluation of hair disorders in comparison with other diagnostic methods.

Objectives: To assess the practicability of uHFUS in diagnosing hair disorders and propose a diagnostic methodology. Read More

Rev Med Liege 2021 May;76(5-6):489-495

Service de Dermatologie, CHU Liège, Belgique.

The management of melanoma is a typical example of a pluridisciplinary approach, in order to provide the patient with a rapid and adequate treatment plan after the initial diagnosis. Both in the domains of dermatology, pathology and oncology, enormous progress has been made. Recent advances permit a rapid access to diagnostic techniques using teledermoscopy, an improved diagnostic accuracy using dermoscopy, pre-interventional high-frequency ultrasound and optical coherence tomography, a determination of risk factors using immunohistochemistry and genetic analyses on the pathology samples. Read More

Ann Dermatol 2021 Jun 4;33(3):275-277. Epub 2021 May 4.

Louis Dermatology Clinic, Guri, Korea.

Clear cell acanthoma (CCA) is an uncommon, benign epithelial tumor presenting as a well-defined, slow-growing solitary nodule. The diagnosis of CCA is usually based on clinical and histopathological evaluation of the tumor. However, when such type of benign tumor occurs on an exposed area, a biopsy is not always the best diagnostic option since it may leave scar. Read More

Ann Dermatol 2021 Jun 4;33(3):214-221. Epub 2021 May 4.

Department of Dermatology, Korea University Ansan Hospital, Ansan, Korea.

Background: Pigmented purpuric dermatosis (PPD) is known as a chronic recurrent eruption which usually presents with petechiae and pigmented macules on the lower extremities. Dermoscopy is a noninvasive diagnostic tool in identifying pigmented and vascular lesions, which can also be beneficial in the evaluation of PPD.

Objective: We aimed to analyze the common dermoscopic characteristics of PPD, and correlate those findings with the histopathologic features. Read More

J Eur Acad Dermatol Venereol 2021 Jun 2. Epub 2021 Jun 2.

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The diagnosis of porokeratosis can be challenging and knowledge about its dermoscopic features is limited.

Objectives: To describe the dermoscopic features of porokeratosis of Mibelli and disseminated superficial actinic porokeratosis (DSAP) and the frequency of these features in a larger case series. The interobserver concordance was also assessed. Read More

Sensors (Basel) 2021 May 16;21(10). Epub 2021 May 16.

College of Computer Science and Engineering, Northwest Normal University, Lanzhou 730070, China.

The automatic segmentation of skin lesions is considered to be a key step in the diagnosis and treatment of skin lesions, which is essential to improve the survival rate of patients. However, due to the low contrast, the texture and boundary are difficult to distinguish, which makes the accurate segmentation of skin lesions challenging. To cope with these challenges, this paper proposes an attention-guided network with densely connected convolution for skin lesion segmentation, called CSAG and DCCNet. Read More

Skin Pharmacol Physiol 2021 May 31:1-10. Epub 2021 May 31.

Berlin Institute of Health, Department of Dermatology and Allergy, Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Clinical Research Center for Hair and Skin Science, Berlin, Germany.

Background And Objectives: Gene mutations within the leptin-melanocortin signaling pathway lead to severe early-onset obesity. Recently, a phase 2 trial evaluated new pharmacological treatment options with the MC4R agonist setmelanotide in patients with mutations in the genes encoding proopiomelanocortin (POMC) and leptin receptor (LEPR). During treatment with setmelanotide, changes in skin pigmentation were observed, probably due to off-target effects on the closely related melanocortin 1 receptor (MC1R). Read More

J Eur Acad Dermatol Venereol 2021 May 31. Epub 2021 May 31.

1st Department of Dermatology-Venereology, Andreas Sygros Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.

Nodular melanoma (ΝΜ) is the most aggressive melanoma subtype and is considered as responsible for more than 40% of melanoma deaths. Early detection of NM is a major challenge, as most NMs lack the ABCD diagnostic criteria and display a nonspecific clinical pattern that may mimic other benign lesions. Read More

Skin Appendage Disord 2021 Apr 17;7(3):234-236. Epub 2021 Feb 17.

1st Department of Dermatology, Faculty of Medicine, National and Kapodistrian University of Athens, Andreas Syggros Hospital, Athens, Greece.

Skin Appendage Disord 2021 Apr 19;7(3):231-233. Epub 2021 Mar 19.

1st Department of Dermatology-Venereology, Andreas Sygros Hospital, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Diagnosis of subungual glomus tumors is mainly based on clinical symptoms, including paroxysmal pain, tenderness, and cold intolerance. Dermoscopy, ultrasonography, and MRI constitute further diagnostic tools, commonly performed to demarcate the tumor before surgery. Herein, we present 2 cases of subungual glomus tumors, which could be diagnosed after fingertip transillumination, highlighting that this technique can serve as an easy, noninvasive, and cost-effective adjuvant diagnostic tool, to facilitate the clinical diagnosis of subungual glomus tumors as well as their localization during preoperative assessment. Read More

Comput Math Methods Med 2021 15;2021:9998379. Epub 2021 May 15.

Deanship of E-Learning and Distance Education, King Faisal University, Saudi Arabia, P.O. Box 400, Al-Ahsa, Saudi Arabia.

In recent years, computerized biomedical imaging and analysis have become extremely promising, more interesting, and highly beneficial. They provide remarkable information in the diagnoses of skin lesions. There have been developments in modern diagnostic systems that can help detect melanoma in its early stages to save the lives of many people. Read More

Clin Exp Dermatol 2021 May 30. Epub 2021 May 30.

Department of Dermatology, Third People's Hospital of Hangzhou, Hangzhou, China.

Dermoscopy is a noninvasive, low-cost method that allows assessment of colors, patterns, and vascular structures, and today we know very well that dermoscopy corresponds well with histopathology. The dermoscopic pattern for early patch stage mycosis fungoides (MF) lesions characteristically consists of fine, short, linear vessels; orange-yellow patchy areas; and spermatozoa like vascular structures. Read More

J Eur Acad Dermatol Venereol 2021 May 29. Epub 2021 May 29.

Dermatology Department, Hospital Clínic & Melanoma Group IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain.

Reflectance confocal microscopy (RCM) has been widely demonstrated to improve the noninvasive diagnostic accuracy of melanocytic tumors . Some studies have focused on studying the use of teleconsultation of RCM images with experts as a promising opportunity for those doctors who have little experience in the field . The clinical diagnosis of Sutton's naevus is usually straightforward : a melanocytic naevus surrounded by a symmetrical white circle ; however, sometimes inflammation makes identifying this entity challenging, as it can present atypical clinical and dermoscopic features. Read More

J Am Acad Dermatol 2021 May 25. Epub 2021 May 25.

Professor at the Department of Dermatology, Hospital das Clínicas of São Paulo University, São Paulo, Brazil.

Clin Exp Dermatol 2021 May 28. Epub 2021 May 28.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Germany.

Background: Basal cell carcinoma (BCC) is the most common skin cancer in the general population. Treatments vary from Mohs surgery to topical therapy, depending on the subtype. Dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) have gained a foothold in daily clinical practice to optimize diagnosis and subtype-oriented treatment. Read More

Dermatol Ther 2021 May 27:e15006. Epub 2021 May 27.

Division of Melanoma Surgery, Sarcoma and Rare Tumors, IRCCS, Istituto Europeo di Oncologia, Milan, Italy.

Basal cell carcinoma (BCC) can sometimes affect the eyelids and in particular the eyelid margin, where it can often be misdiagnosed, mimicking other benign, more common diseases. Dermoscopy may provide additional diagnostic criteria for an earlier diagnosis of eyelid margin BCC, although the dermoscopic features of BCC affecting this anatomical site have seldom been reported. We highlight the peculiar presence of linear vessels perpendicular to the eyelid margin in BCCs of the eyelid margin. Read More

Clin Cosmet Investig Dermatol 2021 18;14:527-539. Epub 2021 May 18.

Department of Plastic Surgery, The 2nd Hospital of Harbin Medical University, Harbin, People's Republic of China.

Purpose: To study the changes in the hair follicle cycle and related stem cells induced by photoaging to establish a mouse model of senescence in hair follicles.

Methods: There were 54 C57BL6/J mice randomly divided into three groups. The UVA group and the UVB group underwent photoaging induced by UV lamps for 8 weeks. Read More

Br J Nurs 2021 May;30(10):574-579

Dermatology Specialist Nurse, Western Isles Hospital.

Background: Teledermatology has been in use as a supplemental tool in dermatology for many years. This study will focus on its use for dermatology patients with suspected skin cancer, in the remote and rural setting.

Objectives: Evaluation of the efficacy and accuracy of skin cancer detection using teledermatology. Read More

Australas J Dermatol 2021 May 25. Epub 2021 May 25.

Department of Pathology, AIIMS, Bhubaneswar, India.

Background: The cutaneous features of acute cutaneous lupus erythematosus (ACLE) can be confused with other dermatoses. The dermoscopic features of ACLE have rarely been reported.

Aims: We aimed to study the dermoscopic features of ACLE, malar rash, and generalized ACLE. Read More

An Bras Dermatol 2021 May 21. Epub 2021 May 21.

Dermatology Service, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Neurofibromatosis is a common genodermatosis, whose diagnosis often involves the participation of a dermatologist. A case of a 38-year-old female patient with four café-au-lait macules and eleven neurofibromas on clinical examination is presented. Dermoscopy allowed the identification of Lisch nodules in the iris, bilaterally. Read More

Actas Dermosifiliogr 2021 May 21. Epub 2021 May 21.

Servicio de Anatomía Patológica. Complejo Hospitalario Universitario de Ferrol. Xerencia de Xestión Integrada de Ferrol. SERGAS. Ferrol, A Coruña, España.

JAAD Case Rep 2021 Jun 18;12:49-50. Epub 2021 Apr 18.

Discipline of Dermatology, Department of Internal Medicine, Medical School of Sciences, Campinas State University-UNICAMP, Campinas, Brazil.

An Bras Dermatol 2021 May 19. Epub 2021 May 19.

Dermatology Discipline, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil. Electronic address:

Total body mapping comprises photographic documentation of the entire body surface followed by digital dermatoscopy of selected melanocytic lesions, aiming to compare their evolution over time and identify new lesions. As this is an exam based on comparative analysis of serial dermoscopic body images, standardization of the technique for performing total body mapping is essential. Prepared by specialists from the Brazilian Society of Dermatology, using the modified Delphi method, this article provides recommendations for carrying out total body mapping in Brazil, regarding its indications, technical aspects, and the issuing of the report. Read More

Dermatol Ther (Heidelb) 2021 May 20. Epub 2021 May 20.

Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie National Research Institute of Oncology (MSCNRIO), Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101, Gliwice, Poland.

Introduction: Chronic graft-versus-host disease (cGvHD) affects around half of allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients, with frequent involvement of the oral mucosa and lip vermillion, that clinically may resemble other autoimmune and inflammatory conditions. Our objectives were to define the dermoscopic patterns of lip vermilion in patients suffering from cGvHD and to compare the presentation with previously published dermoscopic presentations of other disease entities presenting on the lip vermillion.

Methods: A group of 16 patients diagnosed with cGvHD was assessed clinically and dermoscopically. Read More

Int J Dermatol 2021 May 20. Epub 2021 May 20.

Epiphany Dermatology - Dermatology and Mohs Micrographic & Reconstructive Surgery, Dallas, TX, USA.

J Dermatol 2021 May 17. Epub 2021 May 17.

Section of Dermatology, DiSSal, San Martino Polyclinic Hospital IRCCS, University of Genova, Genova, Italy.

We present the case of a 92-year-old woman, with bullous pemphigoid (BP) and a concomitant nevus comedonicus (NC) presenting as an asymptomatic, linear lesion of the entire lower left limb, formed by multiple comedones. Dermoscopy of the NC and histopathology confirmed the clinical and dermoscopic suspect of giant congenital nevus comedonicus. The two entities presented no overlap. Read More

J Dermatol 2021 May 17. Epub 2021 May 17.

Dermatology Section, Department of Medical, Surgical and Neurological Science, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy.

Amelanotic/hypomelanotic melanoma (AHM) represents a clinical diagnostic challenge. Dermoscopy improves AHM diagnosis thanks to visualization of little pigment and vascular pattern. Reflectance confocal microscopy (RCM) increases further the diagnostic accuracy of AHM but few and small studies have described in detail RCM features of AHM. Read More

Dermatol Online J 2021 Apr 15;27(4). Epub 2021 Apr 15.

New York Medical College, School of Health Sciences and Practice, Valhalla, NY.

Background: The SARS-CoV-2/COVID-19 pandemic dramatically impacted the delivery of healthcare, including dermatological services. In the initial stages of the pandemic, reduced patient flow produced a dramatic drop in the volume of skin cancer screening. Consistent with COVID-19 precautions, our practice conducted visual skin examinations (VSE) utilizing semi-automated total body photography (TBP). Read More