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    Dermoscopic features predicting the presence of mitoses in thin melanoma.
    J Dermatol Sci 2017 Feb 3. Epub 2017 Feb 3.
    Skin Cancer Unit, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
    Background: The latest AJCC classification has included the number of mitoses as a factor for upstaging thin melanomas. Meanwhile, while dermoscopy has often been used to predict melanoma thickness, its value in predicting number of mitoses remains unknown.

    Objective: Our aim is to evaluate the correlation between dermoscopic features and the presence of mitoses in a consecutive cohort of thin melanomas. Read More

    Dermoscopy of uncommon variants of dermatofibrosarcoma protuberans.
    J Eur Acad Dermatol Venereol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatology, University of Naples Federico II, Italy.
    Darier-Ferrand dermatofibrosarcoma protuberans (DFSP) is a locally aggressive fibrohistiocytic tumour with a low metastatic potential.(1) Because of its rarity, slow progression and lack of early clinical clues, the diagnosis of DFSP is often delayed. Classical DFSP clinically appeared like an indurated, irregularly-shaped plaques exhibiting flesh to reddish-brown colour. Read More

    Combined in vivo reflectance confocal microscopy and digital dermoscopy for follow up of patients at high risk of malignant melanoma: A prospective case series study.
    J Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Dermatology, University Hospital Fundación Alcorcón, Rey Juan Carlos University, Madrid, Spain.
    Digital dermoscopy (DD) follow up is a useful strategy for monitoring patients at high risk of melanoma. Reflectance confocal microscopy (RCM) is a valuable second-level examination after dermoscopy for the evaluation of difficult to diagnose lesions. The aim of this study was to assess the value of RCM in routine DD monitoring of patients at high risk of melanoma. Read More

    Dermoscopic features of nail psoriasis treated with biologics.
    J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Dermatology, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
    Although psoriatic nail lesions are small, they cause considerable discomfort for patients and adversely affect quality of life. Few studies have evaluated the dermoscopic features of psoriatic nails. The aim of this study was to clarify the dermoscopic features of nail psoriasis and identify those that reflect psoriatic activity. Read More

    A case report of disappearing pigmented skin lesions associated with pembrolizumab treatment for metastatic melanoma.
    Br J Dermatol 2017 Jan 28. Epub 2017 Jan 28.
    Memorial Sloan Kettering Cancer Center, Department of Medicine, Dermatology Service.
    Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo, and lichenoid skin and mucosal reactions. Here, we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes, and scalp and body hair. Read More

    Dermoscopic Findings in Patients with Pigmented Purpuric Dermatoses.
    Acta Dermatovenerol Croat 2016 Dec;24(4):291-295
    Seray Külcü Çakmak, MD, Aykon Park sit. A Blok no:14 742.sokak, Yıldızevler Çankaya,
    Pigmented purpuric dermatoses (PPD) are a group of chronic and relapsing cutaneous disorders characterized by a distinct purpuric rash. The diagnosis is made with clinical and histopathological findings. Dermoscopy has rarely been used in the diagnosis of PPD. Read More

    Melanoma: clinical and dermoscopic diagnosis.
    G Ital Dermatol Venereol 2017 Jan 24. Epub 2017 Jan 24.
    Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
    Missing the diagnosis of a melanoma is the worst dermatologist nightmare, especially when melanomas have a non-alarming clinical appearance and imitate a completely benign lesion. The use of dermoscopy has provided an effective tool to facilitate the differential diagnosis and to increasingly allow an early diagnosis of melanoma. The aim of this article is to summarize the most recent and important clinical and dermoscopic pearls to recognize melanoma at the earliest stages of its development. Read More

    Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
    Br J Dermatol 2017 Jan 24. Epub 2017 Jan 24.
    Dermatology Unit, Second University of Naples, Naples, Italy.
    Spitzoid lesions represent a challenging and controversial group of tumours, in terms of clinical recognition, biologic behavior and management strategies. Although Spitz naevi are considered benign tumours, their clinical and dermoscopic morphologic overlap with spitzoid melanoma renders the management of spitzoid lesions particularly difficult. The controversy deepens because of the existence of tumours that cannot be safely histopathologically diagnosed as naevi or melanomas (atypical Spitz tumours). Read More

    Dermoscopy of Papular Epidermal Nevus with Skyline Basal Cell Layer.
    Pediatr Dermatol 2017 Jan 23. Epub 2017 Jan 23.
    Division of Dermatology "U.O. Multizonale", Outpatient Consultation for Rare Diseases, "S. Chiara" Hospital, Trento, Italy.
    Papular epidermal nevus with skyline basal cell layer (PENS) is a newly described keratinocytic nevus whose dermoscopic characteristics have not been clarified. We used a dermatoscope to investigate the multiple PENSs of a patient with PENS syndrome. All the lesions shared a common dermoscopic homogeneous white pattern surrounded by peripheral, slightly dotted hyperpigmentation. Read More

    The impact of dermoscopy on melanoma detection in the practice of dermatologists in Europe: Results of a pan-European survey.
    J Eur Acad Dermatol Venereol 2017 Jan 21. Epub 2017 Jan 21.
    Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health.
    Background: Dermoscopy is a widely used technique that can increase the sensitivity and specificity of melanoma detection. Information is lacking on the impact of dermoscopy use on the detection of melanoma in the real-life practice of European dermatologists.

    Objective: To identify factors that influence the benefit of using dermoscopy for increasing melanoma detection and lowering the number of unnecessary biopsies in the practice of European dermatologists. Read More

    Nanostructured Lipid Carrier for Topical Application of N-Acetyl Glucosamine.
    Adv Pharm Bull 2016 Dec 22;6(4):581-587. Epub 2016 Dec 22.
    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Purpose: Hyperpigmentation occurs when melanin is overproduced in certain spots on the skin and is one of the most challenging skin conditions to treat. Although it is usually harmless, for cosmetic reasons, it is dreadfully bothersome to those who undergo it. It was reported that N-acetyl-glucosamine (NAGA) prevents melanin synthesis and alters the expression of numerous genes related to pigmentation. Read More

    Dermoscopy of Granuloma Annulare: A Clinical and Histological Correlation Study.
    Dermatology 2017 Jan 19. Epub 2017 Jan 19.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Background: Dermoscopy of granuloma annulare has been investigated by several studies, but none of them took into account the variability of dermoscopic findings according to clinical characteristics and/or histological subtype.

    Objective: To describe the dermoscopic features of classic granuloma annulare and seek possible dermoscopic clues related to specific clinical findings/histological subpatterns.

    Methods: A representative dermoscopic image of a target lesion (the most active lesion underwent histological examination) was retrospectively assessed for the presence of specific morphological findings, correlating them with clinical variables, i. Read More

    Incorporating Colour Information for Computer-Aided Diagnosis of Melanoma from Dermoscopy Images: A Retrospective Survey and Critical Analysis.
    Int J Biomed Imaging 2016 19;2016:4868305. Epub 2016 Dec 19.
    School of Computing Science, Simon Fraser University, Burnaby, BC, Canada.
    Cutaneous melanoma is the most life-threatening form of skin cancer. Although advanced melanoma is often considered as incurable, if detected and excised early, the prognosis is promising. Today, clinicians use computer vision in an increasing number of applications to aid early detection of melanoma through dermatological image analysis (dermoscopy images, in particular). Read More

    Vascular Patterns in Cutaneous Ulcerated Basal Cell Carcinoma: A Retrospective Blinded Study Including Dermoscopy.
    Acta Derm Venereol 2017 Jan 17. Epub 2017 Jan 17.
    Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 11, Piazza Giulio Cesare, Bari, IT-70124 Bari, Italy.
    The aim of this retrospective study was to determine the type and prevalence of vascular patterns in the ulcerated and non-ulcerated portions of histologically proven basal cell carcinomas (BCCs) and correlate them with other dermoscopic and clinical features, including the clinically supposed diagnosis. Three authors retrospectively collected 156 clinical and 156 dermoscopic digital images of ulcerated BCCs (histologically confirmed); each image was blindly evaluated by 2 other authors, who did not know the histological diagnosis. Seventeen lesions were completely ulcerated, while 139 lesions presented ulcerated and non-ulcerated portions. Read More

    Internet-based skin cancer screening using clinical images alone or in conjunction with dermoscopic images: A randomized teledermoscopy trial.
    J Am Acad Dermatol 2017 Jan 12. Epub 2017 Jan 12.
    Dermatology Unit and Teledermatology Network, Virgen Macarena University Hospital, Seville, Spain.
    Background: Teledermoscopy involves the use of dermoscopic images for remote consultation and decision-making in skin cancer screening.

    Objective: We sought to analyze the potential benefits gained from the addition of dermoscopic images to an internet-based skin cancer screening system.

    Methods: A randomized clinical trial assessed the diagnostic performance and cost-effectiveness of clinical teleconsultations (CTC) and clinical with dermoscopic teleconsultations. Read More


    Nodular hidradenoma: Dermoscopic presentation.
    J Am Acad Dermatol 2017 Feb;76(2S1):S46-S48
    Department of Dermatology, University Hospital "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address:

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