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J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Osaka Police Hospital, Osaka, Japan.

Pigmented Bowen's disease (pBD) is a subtype of Bowen's disease, which presents clinically as a well-circumscribed, hyperpigmented plaque. Its clinical manifestations are not fully characterized, and differential diagnoses include various pigmented skin lesions. Dermoscopy could be useful for the diagnosis, although nothing has been reported on the dermoscopic features of clonal-type pBD. Read More

Dermatol Ther 2019 Feb 14:e12863. Epub 2019 Feb 14.

Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Fed Pract 2018 May;35(Suppl 4):S39-S45

is a Medical Student at the University of California, Riverside in Riverside, California. is a Medical Student, is a PGY-2 Dermatology Resident, and is a PGY-4 Dermatology Resident, all at Loma Linda University in Loma Linda, California. is the Dermatology Section Chief and Professor of Dermatology, and is the Dermatology Clinical Director and Assistant Professor of Dermatology, both at Loma Linda University and the Loma Linda VA Medical Center.

Use of dermoscopy and detection algorithms by primary care physicians can enhance assessment of clinically suspicious lesions compared with that of naked eye examinations. Read More

J Am Acad Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:

Background: Longitudinal melanonychia (LM) is a common finding in clinical practice; however, it has a broad differential diagnosis, including subungual melanoma (SUM), which can be difficult to distinguish clinically from benign conditions.

Objective: To identify clinical and dermoscopic features that distinguish histopathologically diagnosed SUM from benign LM and to evaluate the validity of the ABCDEF criteria among patients on whom a biopsy was performed.

Methods: Retrospective cohort study of consecutive patients who underwent nail matrix biopsy for LM at a single center from January 2011 to November 2017. Read More

G Ital Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

First Department of Dermatology, Aristotle University, Thessaloniki, Greece -

Since their first description by Sophie Spitz, Spitz nevi have been a subject of controversy among clinicians for many decades, and remain a clinical conundrum until today as their etiology, morphology, biological behavior and natural evolution is still not totally clear. This is becauase their clinical, dermoscopic and histopathologic features sometimes overlap with those of melanoma, rendering the management of spitzoid lesions particularly difficult. In addition, cases of histopathologically equivocal lesions do exist and their classification might sometimes be very challenging. Read More

J Eur Acad Dermatol Venereol 2019 Feb 11. Epub 2019 Feb 11.

Dermatology department, Hospital de la Santa Creu i Sant Pau.

Diagnosis of actinic keratosis (AK) is mainly clinical, but dermoscopy has proven useful in improving diagnostic accuracy. The patterns, structures and colors of AK can vary widely. Lesions may appear as white scales on a pseudo-network pattern, as keratotic plugs on a scaly white to yellow background, or as a strawberry pattern with white to yellow areas and keratotic follicular openings on an erythematous background. Read More

Clin Exp Dermatol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology. Hospital Universitari Arnau de Vilanova, University of Lleida. IRBLleida. Lleida. Catalunya, Spain.

A 69-year-old Caucasian woman suffering from long-term diabetes mellitus type II was referred to our dermatology department with cutaneous lesions that appeared 3 years before. They were itchy and non-tender, and spreaded progressively, with no history of previous trauma. Examination revealed multiple erythematous to yellowish papules on the lower legs, which merged in plaques, of varying shapes and sizes (Fig. Read More

J Am Acad Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea. Electronic address:

Acral lentiginous melanoma is a distinct subtype of melanoma on acral skin. Patient presentation at later stages as well as delayed diagnosis by physicians contribute to a worse associated prognosis and survival rate. Despite our progress on understanding the key features of this disease, the diagnosis of early stage acral melanoma is still challenging. Read More

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, University Hospital of Saint-Etienne, 42055 Saint-Etienne Cedex 2, France.

There are only case reports concerning dermoscopy of eyelid margin tumours. We evaluated the clinical and dermoscopic features of 165 eyelid margin tumours of 145 consecutive patients (77 females, 68 males, mean age 64·3 years, standard deviation - SD 17·94, range 10 - 95 years) recruited at the Dermatology Department of the University Hospital of Saint-Etienne, France, between September 1st, 2013 and January 30th, 2017 to exclude malignant tumours. This article is protected by copyright. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):93-95

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States of America.

Reflectance confocal microscopy (RCM) is a noninvasive imaging technique that allows visualization of the epidermis and papillary dermis with cellular-level resolution. Granulomatous reactions such as sarcoidosis could be assessed using RCM. The identification of bright beaded-like structures that could correspond to reticulin fibers overlying granulomas, in association with dermoscopy, may be a very useful approach in the diagnosis of sarcoidosis and for the differentiation of this granulomatous entity with superficial cutaneous metastasis. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):86-88

Department of Dermatology and Venereology, China-Japan Friendship Hospital, Beijing, China.

We report a case of amelanotic acral melanoma in a 42-year-old Chinese woman. Ten months previously the patient found a 2-cm asymmetric erythematous macular plaque on her left sole. The lesion was diagnosed as verruca plantaris by every physician the patient consulted. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):79-81

Department of Pathology, Hospital Militar Central, Universidad Militar Nueva Granada, Bogotá, Colombia.

We report the case of a 47-year-old male patient with S100 negative granular cell tumor of the oral cavity, focusing on dermoscopic features as well as surgical approach, not previously reported in the literature. The study contributes to the literature on dermoscopy and surgical treatment for this tumor and provides a practical approach to differentiating non-neural granular cell tumors and granular cell tumors. Read More

PLoS One 2019 6;14(2):e0211318. Epub 2019 Feb 6.

Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland.

This article refers to the Computer Aided Diagnosis of the melanoma skin cancer. We derive wavelet-based features of melanoma from the dermoscopic images of pigmental skin lesions and apply binary C-SVM classifiers to discriminate malignant melanoma from dysplastic nevus. The aim of this research is to select the most efficient model of the SVM classifier for various image resolutions and to search for the best resolution-invariant wavelet bases. Read More

Australas J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Dermatology Unit, University of Campania 'Luigi Vanvitelli', Naples, Italy.

Phys Med Biol 2019 Feb 1. Epub 2019 Feb 1.

Bioengineering, University of Washington, 5306 24th Ave NE #202, Foege Building, Rm #N410E, Seattle, Washington, 98195, UNITED STATES.

Despite our understanding that the microvasculature plays a multifaceted role in the development and progression of various conditions, we know little about the extent of this involvement. A need exists for non-invasive, clinically meaningful imaging modalities capable of elucidating microvascular information to aid in our understanding of disease, and to aid in the diagnosis/monitoring of disease for more patient-specific care. In this review article, a number of imaging techniques are summarized that have been utilized to investigate the microvasculature of skin, along with their advantages, disadvantages and future perspectives in preclinical and clinical settings. Read More

J Am Acad Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston TX.

IEEE J Biomed Health Inform 2019 Jan 28. Epub 2019 Jan 28.

Dermoscopy is a non-invasive skin imaging technique that permits visualization of features of pigmented melanocytic neoplasms that are not discernable by examination with the naked eye. While studies on the automated analysis of dermoscopy images date back to the late 1990s, because of various factors (lack of publicly available datasets, open-source software, computational power, etc.), the field progressed rather slowly in its first two decades. Read More

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Department of Dermatology, University of California Irvine, Irvine, California.

Comma and corkscrew hairs are trichoscopic markers of tinea capitis. Although comma hairs have been reported in both black and white patients with tinea capitis, corkscrew hairs were previously hypothesized to manifest exclusively in patients with curly or African hair types. However, we report a significant number of comma and corkscrew hairs in a Hispanic female patient with naturally straight hair and Trichophyton tonsurans tinea capitis. Read More

J Cosmet Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Department of Community Medicine, Hind Institute of Medical Sciences, Lucknow, India.

Background: Platelet-rich plasma (PRP) is a popular procedure for the treatment of androgenetic alopecia (AGA).

Aim: To ascertain the role of minoxidil 5% lotion alone versus minoxidil 5% lotion and PRP versus minoxidil 5% lotion, PRP with microneedling in AGA.

Material And Methods: Ninety-three AGA patients with Hamilton-Norwood score 1-5 were grouped into three groups A, B, and C. Read More

Clin Exp Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Policlinico Sant'Orsola-Malpighi, University of Bologna, Italy.

Squamous cell carcinoma (SCC) is the most common malignant vulvar tumor.1 It primarily affects post-menopausal women; its precursor lesions are vulvar intraepithelial neoplasia (VIN), in particular the "differentiated" subtype, and/or human papillomavirus (HPV) infection.1 The final diagnosis of vulvar SCC is made by histopathology, which is similar to that of SCC affecting other body areas, distinguishing between well differentiated forms and poorly differentiated tumors. Read More

Exp Ther Med 2019 Feb 16;17(2):1052-1060. Epub 2018 Nov 16.

Department of Physiology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Lichen planus (LP) is a chronic inflammatory skin disease that can sometimes affect mucosal surfaces, with unknown pathogenesis, even though it appears to be an autoimmune disease. The diagnosis of lichen planus is usually based on histopathological examination of the lesions. Nowadays, the classical invasive diagnostic methods are replaced by modern non-invasive techniques. Read More

Pediatr Dermatol 2019 01;36(1):179

Departments of Dermatology and STD and Pathology, University College of Medical Sciences and GTB Hospital, Delhi, India.

Int J Dermatol 2019 Mar 24;58(3):e68-e71. Epub 2019 Jan 24.

Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

EBioMedicine 2019 Jan 20. Epub 2019 Jan 20.

Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Background: Early diagnosis of skin cancer lesions by dermoscopy, the gold standard in dermatological imaging, calls for a diagnostic upscale. The aim of the study was to improve the accuracy of dermoscopic skin cancer diagnosis through use of novel deep learning (DL) algorithms. An additional sonification-derived diagnostic layer was added to the visual classification to increase sensitivity. Read More

IEEE Trans Med Imaging 2019 Jan 21. Epub 2019 Jan 21.

Automated skin lesion classification in dermoscopy images is an essential way to improve the diagnostic performance and reduce melanoma deaths. Although deep convolutional neural networks (DCNNs) have made dramatic breakthroughs in many image classification tasks, accurate classification of skin lesions remains challenging due to the insufficiency of training data, inter-class similarity, intra-class variation, and lack of the ability to focus on semantically meaningful lesion parts. To address these issues, we propose an attention residual learning convolutional neural network (ARL-CNN) model for skin lesion classification in dermoscopy images, which is composed of multiple ARL blocks, a global average pooling layer, and a classification layer. Read More

J Dtsch Dermatol Ges 2019 Jan 22. Epub 2019 Jan 22.

Department of Dermatology, Medical University of Graz, Graz, Austria.

Background And Objective: Benign and malignant facial skin lesions may be difficult to differentiate clinically and with dermoscopy. The present study aimed to evaluate the potential utility of in vivo reflectance confocal microscopy (RCM) as a second-level examination for facial skin neoplasms.

Patients And Methods: Retrospective and blinded evaluation of 160 consecutive facial lesions was carried out in two separate steps. Read More

Clin Exp Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, 160012, India.

Ann Dermatol Venereol 2019 Jan 17. Epub 2019 Jan 17.

Service de dermatologie, hôpital universitaire de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.

J Cosmet Dermatol 2019 Jan 20. Epub 2019 Jan 20.

Department of Dermatology, Purnam Skin Clinic, Kolkata, India.

Background: Lichen Planus Pigmentosus (LPP), a disorder with stubborn treatment-refractory hyperpigmentation predominantly affects the darker skin. Deep dermal pigmentary incontinence of LPP renders the condition treatment-refractory.

Objectives: Lack of a consistently effective depigmenting treatment protocol of inactive LPP mandates exploration of novel approaches. Read More

Dermatol Ther 2019 Jan 18:e12831. Epub 2019 Jan 18.

Department of Dermatology & STD, NDMC Medical College & Hindu Rao Hospital, New Delhi, India.

Background: Platelet rich plasma (PRP) is essentially an increased concentration of autologous platelets (growth factors) suspended in small amount of plasma. These factors have a proliferative and regenerative effect on a number of tissues in body and have been extensively used in dermatology, surgery, orthopedics and dentistry.

Case Report: Two patients, one with nail lichen striatus and second with idiopathic trachyonychia were treated with intramatriceal injections of platelet rich plasma. Read More

J Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

Clin Exp Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Dermatology Department, Hospital Universitario Professor Edgard Santos, Federal University of Bahia, Bahia, Brazil.

Oculocutaneous albinism (OCA) increases predisposition to skin malignancies. Nevertheless, the differential diagnosis between melanoma and naevi in patients with OCA is still challenging, because pigmentary lesions have rarely been described in this population. We aimed to describe the dermoscopic patterns of naevi in patients with OCA. Read More

Int J Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Dermatopathology Service, Simon Bolívar Hospital, Bogotá, Colombia.

Introduction: Angiokeratoma corporis diffusum are benign capillary malformations typically associated with Fabry disease and other lysosomal storage disorders. Only in a few cases they appear in healthy individuals.

Methods And Case: We carried out an exhaustive review of the literature on angiokeratomas and their main clinical, dermoscopy and histological features. Read More

Int J Dermatol 2019 Mar 17;58(3):345-349. Epub 2019 Jan 17.

Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: Several dermoscopy training programs have found the accuracy of dermoscopy examination depends on adequate training of practitioners. Smartphones are readily available and time-efficient tools for dermoscopy training.

Aim: To evaluate the learning efficacy of utilizing dermoscopy smartphone wallpapers to train medical students, PGY (postgraduate year)-1 trainees, and junior dermatological residents without prior dermoscopy training. Read More

Australas J Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, School of Medicine, Ankara University, Ankara, Turkey.

Clin Case Rep 2019 Jan 4;7(1):189-192. Epub 2018 Dec 4.

Sanglah General Public Hospital Denpasar Indonesia.

Angiolymphoid Hyperplasia with Eosinophilia (ALHE) is a benign tumor of the skin which may mimic other benign or malignant lesion of the skin. Practitioners should consider this diagnosis as a differential when encounter such lesion as papule or nodule on the face and scalp area. Read More

Clin Case Rep 2019 Jan 22;7(1):146-148. Epub 2018 Nov 22.

Department of Dermatology College of Medical Sciences Bharatpur Nepal.

Lichen planus (LP) of lip has chances of malignant transformation as it may be exposed to external trauma, smoking, and ultraviolet light. This case highlights the use of dermoscope as a quick noninvasive tool for the diagnosis of LP of lip and monitoring the response to treatment. Read More

J Am Acad Dermatol 2019 Jan 14. Epub 2019 Jan 14.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.

J Biophotonics 2019 Jan 17:e201800391. Epub 2019 Jan 17.

Department of Dermatology and Allergy, University Hospital Munich, Munich, Germany.

Actinic keratosis (AKs) corresponds to the earliest stage of in-situ squamous cell carcinoma and arises on chronically sun-exposed skin. Around the clinically evident AKs, the apparently healthy epidermis may contain different grades of atypia that can be detected by non-invasive imaging techniques such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Subclinical actinic keratosis (sAKs) have captured increasing interest as a potential target of field therapies. Read More

Lasers Surg Med 2019 Jan 17. Epub 2019 Jan 17.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York.

Objectives: Early melanoma detection decreases morbidity and mortality. Early detection classically involves dermoscopy to identify suspicious lesions for which biopsy is indicated. Biopsy and histological examination then diagnose benign nevi, atypical nevi, or cancerous growths. Read More

Skin Appendage Disord 2018 Nov 25;5(1):46-49. Epub 2018 Jun 25.

Skin and Soft Tissue Department, Instituto Nacional de Cancerología, Mexico City, Mexico.

Cutaneous metastasis is a rare event occurring most frequently in patients previously diagnosed with cancer. However, subungual metastases are even less frequent. The most common neoplasms associated with the latter are lung, kidney, and breast neoplasms. Read More

Skin Appendage Disord 2018 Nov 18;5(1):1-8. Epub 2018 Jul 18.

Department of Dermatology, University of Miami, Miami, Florida, USA.

Trichoscopy (dermoscopy of the hair and scalp) is a technique that improves diagnostic accuracy and follow-up with hair and scalp disorders. Although several studies of trichoscopy have been made in Caucasian and Asian populations, little has been published regarding trichoscopy findings in skin of color, despite the great prevalence of hair diseases in populations with this kind of skin. The aim of this review was to describe the trichoscopic features of normal scalp and of hair disorders in patients with dark skin phototypes. Read More

J Am Acad Dermatol 2019 Jan 11. Epub 2019 Jan 11.

College of Medical Sciences, Department of Dermatology, Bharatpur, Nepal.

Med J Aust 2019 Jan 2;210(1):41-47. Epub 2018 Dec 2.

Melanoma Institute Australia, Sydney, NSW.

Introduction: The evidence-based national clinical practice guidelines for the management of cutaneous melanoma published in 2008 are currently being updated. This article summarises the findings from multiple chapters of the guidelines on different methods of melanoma detection and of monitoring the skin for patients at high risk of melanoma. Early detection of melanoma is critical, as thinner tumours are associated with enhanced survival; therefore, strategies to improve early detection are important to reduce melanoma-related mortality. Read More

Acta Derm Venereol 2019 Jan 9. Epub 2019 Jan 9.

Department of Dermatology and Venereology, Skåne University Hospital, SE-205 02 Malmö, Sweden.

Photodiagnosis Photodyn Ther 2019 Jan 6. Epub 2019 Jan 6.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: Hemoporfin-mediated photodynamic therapy (HMME-PDT) is an effective method for treating port wine stains (PWS). While, it still lacks methods to evaluate the treatment of HMME-PDT for PWS effectively and objectively.

Objective: This study aimed to compare the value of different non-invasive diagnostic techniques used for HMME-PDT treatment evaluation in PWS. Read More

IEEE J Biomed Health Inform 2019 Jan 4. Epub 2019 Jan 4.

This paper presents an approach that combines conventional image processing with deep learning by fusing the features from the individual techniques. We hypothesize that the two techniques, with different error profiles, are synergistic. The conventional image processing arm uses three handcrafted biologically inspired image processing modules and one clinical information module. Read More

Postepy Dermatol Alergol 2018 Dec 8;35(6):577-581. Epub 2018 Nov 8.

Department of Dermatology, Venereology and Allergology, Faculty of Medicine and Dentistry, Wroclaw Medical University, Wroclaw, Poland.

Introduction: Alopecia areata (AA) is a skin disease of unclear etiology. In AA, topical immunotherapy with diphenylcyclopropenone (DPCP) is considered the most effective treatment; however, the most common therapies give unsatisfactory results.

Aim: To assess the efficacy of a topical application of a solution of DPCP based on the intensity, duration and number of exacerbations of AA and to compare the efficacy of two treatment regimens. Read More

Lasers Med Sci 2019 Jan 4. Epub 2019 Jan 4.

Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Fractional CO laser rejuvenation of scars offers a high safety profile. Laser marks usually disappear clinically within 1 week. The authors observed occasional persistence of the laser marks on the scar surface. Read More