Search Our Scientific Publications & Authors

PLoS One 2019 22;14(4):e0215379. Epub 2019 Apr 22.

Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Germany.

Non-melanoma-skin cancer is an emerging clinical problem in the elderly, fair skinned population which predominantly affects patients aged older than 70 years. Its steady increase in incidence rates and morbidity is paralleled by related medical costs. Despite the fact that many elderly patients are in need of care and are living in nursing homes, specific data on the prevalence of skin cancer in home care and the institutional long-term care setting is currently lacking. Read More

Int J Trichology 2019 Mar-Apr;11(2):93-95

Department of Laboratory and Blood Bank, King Fahd Hospital, Hofuf, Al-Ahsa, Saudi Arabia.

Int J Trichology 2019 Mar-Apr;11(2):58-67

Department of Dermatology, Government Medical College, Bhavnagar, Gujarat, India.

Aim: This study aims to compare efficacy and safety between mesotherapy (intralesional injection) and 5% topical minoxidil solution in male androgenic alopecia (AGA) by dermoscopic evaluation.

Methodology: In a randomized active controlled trial, we enrolled 49 clinically diagnosed males of AGA and randomly allotted them into two groups - mesotherapy (A) (25) and minoxidil (B) (24). Males in Group A were given total 8 sessions of intralesional mesosolution with microneedling procedure while Group B males were prescribed topical solution of minoxidil 5% twice daily for 4 months. Read More

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

First Dermatology Department, Aristotle University of Thessaloniki, Greece.

Pagetoid reticulosis (PR), also known as Woringer-Kolopp disease, is a rare variant of mycosis fungoides with distinctive clinicopathologic features. It clinically manifests as a solitary, erythematous, gradually enlarging, scaly or verrucous plaque on the lower extremities, and due to its indolent course and non-specific clinical features, may remain undiagnosed for years. In the current we describe the clinical and dermoscopic characteristics of a rare case of PR disease, and correlate them with the corresponding histopathologic findings. Read More

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Urgences pédiatriques, Centre Hospitalier Universitaire Hôpital pédiatrique Lenval, Nice, France.

Background: Expert visualization of Sarcoptes scabiei remains essential for diagnosing human scabies but access to experts can be difficult. PCR is a very specific tool for the detection and confirmation of Sarcoptes scabiei but this test has a poor sensitivity because of the requirement of previous expertise when collecting appropriate samples to gain a positive result.

Objective: Evaluate PCR as a diagnostic method for scabies using non expert-dependent standardized sampling. Read More

Australas J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatology Service, Hospital Fundación de Alcorcón, Madrid, Spain.

Background/objectives: Lentigo maligna is usually located on the face. Extrafacial lentigo maligna is less common, and diagnosis of early forms is very difficult. Confocal microscopy of facial and extrafacial lentigo maligna shares the same features (abundant dendritic cells and generalised atypical junctional thickenings) and helps us to identify the dermoscopic features of extrafacial lentigo maligna. Read More

Clin Case Rep 2019 Apr 17;7(4):612-615. Epub 2019 Feb 17.

Dermatology Service of Clinics Hospital of Uberlandia (HCU/UFU) Federal University of Uberlandia (UFU) Uberlândia Brazil.

Cutaneous lymphangioma circumscriptum (CLC) is a rare congenital malformation of the superficial cutaneous lymphatic ducts. Case report: A 7-year-old boy presented plaque with grouped vesicles resembling a "frog spawn" on the upper left thigh, since 4 months old. The clinical, dermatoscopic and histopathological correlation is of great importance. Read More

Oncol Res Treat 2019 Apr 17:1-6. Epub 2019 Apr 17.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany,

Background: Videodermatoscopy (VD) is a useful device for supporting dermatologists in the distinction between benign and malignant lesions. However, only few patients have access to VD in daily practice.

Objectives: To investigate patient attitudes towards VD. Read More

JAAD Case Rep 2019 Apr 2;5(4):323-325. Epub 2019 Apr 2.

Department of Dermatology, Medical Faculty, Ege University, Izmir, Turkey.

J Clin Med 2019 Apr 3;8(4). Epub 2019 Apr 3.

Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Current national and European guidelines recommend distinct management approaches for basal cell carcinoma (BCC) based on tumor location, size, and histopathological subtype. In vivo reflectance confocal microscopy (RCM) is a non-invasive skin imaging technique which may change the diagnostic pathway for BCC patients. This study aimed to determine the sensitivity and specificity of RCM for BCC diagnosis, assess the predictive values of several confocal criteria in correctly classifying BCC subtypes, and evaluate the intraobserver reliability of RCM diagnosis for BCC. Read More

Indian Dermatol Online J 2019 Mar-Apr;10(2):210-211

Senior Consultant Dermatologist and Dermatosurgeon, Department of Dermatology, Skinnocence: The Skin Clinic and Research centre, Gurugram, Haryana, India.

Indian Dermatol Online J 2019 Mar-Apr;10(2):208-209

Department of Dermatology, Mayo Clinic, Jacksonville, Florida, USA.

Indian Dermatol Online J 2019 Mar-Apr;10(2):206-207

Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India.

Indian J Dermatol 2019 Mar-Apr;64(2):155-157

Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Coexistence of two types of malignant neoplasms, called 'a collision tumor,' is relatively uncommon. Basal cell carcinomas (BCCs) are known to coexist with other cutaneous lesions, but the collision of BCC with malignant melanoma is rare. We report a rare case of BCC with underlying lentigo maligna melanoma, focusing on dermoscopic and reflectance confocal microscopic (RCM) findings and their correlation with histopathology. Read More

Australas J Dermatol 2019 Apr 14. Epub 2019 Apr 14.

Department of Dermatology, Hospital Universitario Central de Asturias, Oviedo, Spain.

J Am Acad Dermatol 2019 05;80(5):e99-e100

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Ankara University, Faculty of Medicine, Department of Pathology, Ankara, Turkey.

Cutaneous adnexial tumours derived from the outer root sheath of hair follicles are trichilemmal tumours or pilar cysts. These tumours show trichilemmal keratinization as formation of a dense keratin layer without interposition of the granular cell layer. Trichilemmal cysts can form rapidly multiplying trichilemmal tumors, also called proliferating trichilemmal tumour (PTT) or cyst. Read More

J Eur Acad Dermatol Venereol 2019 Apr 12. Epub 2019 Apr 12.

The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, UK.

Background: Melanoma accounts for 90% of skin cancer mortality and typically presents in primary care, where it can be challenging to distinguish from benign lesions. Dermoscopy is a tool for skin visualisation that is routinely used for melanoma diagnosis in secondary care. However, the role of dermoscopy in primary care remains unclear. Read More

Br J Dermatol 2019 Apr 12. Epub 2019 Apr 12.

APHP Service de Dermatologie, Hôpital Saint-Louis, Paris.

Dermoscopy was proven more accurate than naked-eye examination and sequential digital dermoscopy imaging (SDDI) superior to dermoscopy alone for melanoma detection . SDDI combined with total-body photography (TBP) namely the "two-step method" of digital follow-up (DFU), seems at present the best surveillance strategy for high risk patients. With the aim to endorse its usefulness, we retrospectively studied 148 at high risk patients included in DFU at the Dermato-oncology Unit of Hôpital Saint-Louis between 2014 and 2018. Read More

Open Access Maced J Med Sci 2019 Mar 27;7(6):973-977. Epub 2019 Mar 27.

Section of Dermatology, University of Naples Federico II, Naples, Italy via Sergio Pansini 5, 80131 Naples, Italy.

Background: Tyrosine kinase inhibitors (TKIs) have been introduced for the treatment of lung cancer, improving progression-free survival, objective response rate, and quality of life. However, TKIs can lead to cutaneous toxicities, including papulopustular rash, xerosis, paronychia with/without pyogenic granulomas, scalp disorders, facial hair and/or eyelash growth.

Aim: In this study, we describe retrospectively all cases of mucocutaneous side effects in patients with lung cancer under TKIs referring to our outpatient for the skin care of oncological patients. Read More

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Italy.

Background: In-vivo reflectance confocal microscopy significantly improves melanoma diagnosis as compared to clinical/dermoscopic examination alone. Several confocal criteria have been described allowing to differentiate melanoma from nevi; by combining different criteria three pure confocal scores (Pellacani 2005, Segura 2009 and Pellacani 2012) and one mixed dermoscopic/confocal score (Borsari 2018) were constructed.

Objective: Our aim was to externally validate and compare the performance of these confocal scores. Read More

Dermatol Ther 2019 Apr 9:e12908. Epub 2019 Apr 9.

Dermatologic Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.

Basal cell carcinomas are the most common non-melanoma skin cancers. Dermoscopy is an indispensable tool to differentiate superficial basal cell carcinoma from other subtypes and between pigmented and not pigmented ones. Although surgery is considered the gold-standard therapy, new current pharmacological options are available and focus on tumor eradication, increasing cosmetic results and functionality. Read More

Dermatol Ther (Heidelb) 2019 Apr 9. Epub 2019 Apr 9.

Dermatology Unit, Second University of Naples, Nuovo Policlinico (Edificio 9C), Via Pansini 5, 80131, Naples, Italy.

Actinic keratosis (AK) is a common pathology that afflicts sun-exposed areas of the skin. It predominantly affects older and fair-skinned individuals suggesting an accumulative damage attributable to chronic sun exposure. The prevalence of AK has risen in the past decades and is expected to continue to rise. Read More

Australas J Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background/objectives: Videodermoscopy is a valuable tool for the diagnosis of cicatricial alopecias such as lichen planopilaris. Lichen planopilaris activity index is used for evaluating lichen planopilaris severity. Our aim was to examine the utility of videodermoscopy in the assessment of lichen planopilaris severity. Read More

J Am Acad Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Senior Consultant & Director, Timpac Healthcare Pvt. Ltd., New Delhi, India.

Indian J Dermatol Venereol Leprol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Clin Exp Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

A 54-year-old Japanese woman presented with a brown-to-black variegated, verrucous nodule measuring 37 mm x 29 mm on the medial aspect of her left heel (Fig. 1a). Dermoscopy showed an exophytic papillary structure with fissures and ridges on the central nodule, accompanied by a parallel ridge pattern on the periphery (Fig. Read More

Oncol Lett 2019 May 19;17(5):4176-4182. Epub 2018 Nov 19.

Department of Dermatology, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.

Melanoma is one of the most immunogenic tumors among human neoplasms, with numerous clinical observations of partial or completely regressed tumors. It is an aggressive tumor, with the greatest reported number of somatic mutations, BRAF mutation being the most common one. BRAF mutation is also present in a higher percentage in benign nevi. Read More

Oncol Lett 2019 May 25;17(5):4112-4125. Epub 2019 Feb 25.

Department of Dermatology, 'Prof. N. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania.

Basal cell carcinoma (BCC) is the most prevalent skin cancer in the Caucasian population. A variety of different phenotypic presentations of BCC are possible. Although BCCs rarely metastasize, these tumors commonly destroy underlying tissues and should therefore be treated promptly. Read More

Oncol Lett 2019 May 27;17(5):4094-4101. Epub 2019 Feb 27.

Department of Dermatology, 'Prof. N. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania.

Bowen's disease (BD) is a relatively frequent non-melanoma skin cancer occurring mostly in elderly people. Until now, the usual way to establish the diagnosis is histopathological examination of a skin biopsy. Dermoscopy and reflectance confocal microscopy (RCM) are modern alternative methods that can be used as quick and non-invasive diagnostic techniques and as follow-up instruments in cases in which a conservative treatment is chosen for the management of BD. Read More

Australas J Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Background/objectives: High a naevus counts and atypical naevi are risk factors for cutaneous melanoma. However, many individuals with a high-risk naevus phenotype do not develop melanoma. In this study, we describe the clinical and dermoscopic attributes of naevi associated with melanoma in a high-risk naevus phenotype population. Read More

Acta Derm Venereol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Hospital Clínic de Barcelona, IDIBAPS, ES-08036 Barcelona, Spain.

Patients treated with haematopoietic stem cell transplantation are at increased risk of cutaneous malignant neoplasms. There are no reports on the characteristics of melanocytic lesions in patients with chronic graft versus host disease and the value of recognizing these difficult lesions in high-risk patients. The objective of this study is to describe the clinical and dermoscopic characteristics of melanocytic lesions in patients with chronic graft versus host disease in order to understand their morphology. Read More

Photochem Photobiol Sci 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgical, Medical, Dental & Morphological Sciences with Interest Transplant, Oncological & Regenerative Medicine, Dermatology Unit, University of Modena & Reggio Emilia, Modena, Italy.

In vivo reflectance confocal microscopy (RCM) is a noninvasive high-resolution skin imaging tool that has become an important adjunct to clinical exam, dermoscopy and histopathology assessment, in the diagnosis and management of pigmented macules of the face. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging and RCM improves the diagnostic accuracy in the differential diagnosis of LM with other macules of the face such as solar lentigo (SL), pigmented actinic keratosis (PAK), seborrheic keratosis (SK) and lichen planus-like keratosis (LPLK). Here we review the state-of-the-art of RCM morphologic descriptors, standardized terminology, and diagnostic algorithms for the RCM assessment of pigmented macules of the face including melanocytic, and nonmelanocytic lesions. Read More

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China. Electronic address:

Background: Nail matrix histopathological examination is still the gold standard to diagnose longitudinal melanonychia (LM).

Objective: To introduce modified shave surgery combined with nail window technique for managing LM, and evaluate the postoperative outcome of the procedure.

Methods: We retrospectively reviewed the medical records of 67 cases with LM who underwent shave surgery combined with longitudinal-strip nail window technique at our institution from March 2015 to June 2018. Read More

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, University of Connecticut Health Center, Farmington, CT.

There are multiple, genetically distinct pathways that give rise to melanoma. Melanomas on sun damaged skin (MSDS) - including lentigo maligna (LM) and desmoplastic melanoma (DM) - have distinct genetic profiles and are uniquely linked to chronic ultraviolet (UV) exposure. In this article we discuss the etiologies of LM and DM, emerging diagnostic adjuncts that may be helpful in accurately identifying these lesions, and the clinical relevance of their frequent co-occurrence. Read More

Actas Dermosifiliogr 2019 Mar 26. Epub 2019 Mar 26.

Departamento de Dermatología, Universidad de Tor Vergata, Roma, Lazio, Italia.

Background: Seborrheic keratoses (SK) are easily recognizable by clinical and dermoscopic approach, nevertheless, some lesions act as a simulator of different skin conditions lacking typical clinical and dermoscopic criteria.

Objective: The aim of our study was to find specific dermoscopic features or a global pattern to improve diagnostic skills for challenging SK.

Materials And Methods: We examined 72 atypical SK excised from September 2014 up to September 2017 by using the 2-step algorithm modified by Malvehy (2002) and Argenziano (2003). Read More

J Am Acad Dermatol 2019 Mar 23. Epub 2019 Mar 23.

Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.

Background: Clinical differentiation of folliculitis types is challenging. Dermoscopy supports the recognition of folliculitis etiology but its diagnostic accuracy is not known.

Objective: To assess the diagnostic accuracy of dermoscopy for folliculitis. Read More

Eur J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Recurrent nevi occur following removal of melanocytic nevi mainly after shaving excision. Due to its differential diagnosis with melanoma, its recognition can be challenging. To evaluate clinical and dermoscopic predictors of recurrent nevi. Read More

Clin Case Rep 2019 Mar 25;7(3):431-434. Epub 2019 Jan 25.

Department of Dermatology College of Medical Sciences Bharatpur Nepal.

Secondary syphilis may have a varied clinical presentation and might pose a diagnostic difficulty when a typical history is absent. We describe the dermoscopic clues of the skin lesions at different stages of the disease which could culminate to a proper diagnosis. Read More

J Cosmet Dermatol 2019 Mar 20. Epub 2019 Mar 20.

Department of Community Medicine, School of medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Androgenetic alopecia is the most common type of hair loss in men, which is manifested by a progressive terminal hair loss in specific areas of scalp. Platelet-rich plasma (PRP) is among treatment options for androgenetic alopecia. PRP is a human platelet concentrate in a small volume of plasma containing certain cytokines. Read More

Australas J Dermatol 2019 Mar 20. Epub 2019 Mar 20.

Dermatology Department, Hospital Sant Pau i Santa Tecla, Tarragona, Spain.

Hautarzt 2019 Apr;70(4):295-311

Hautarzt- und Lehrpraxis, Konstanz, Deutschland.

The use of dermoscopy by dermatologists across Europe has become a standard examination for benign and malignant skin lesions and increasingly also for inflammatory skin diseases. However, based on the experience of the authors from numerous dermoscopy courses, knowledge about important dermoscopic features in special locations such as mucosa or nails is often limited. This may be explained by (1) a different anatomy of the skin and its adnexa in special locations in comparison to the remaining integument, (2) difficult technical access to special locations with a dermatoscope, and (3) a rather low incidence of malignant skin neoplasms in areas of special locations (with the exception of facial skin/scalp). Read More

Open Access Maced J Med Sci 2019 Feb 22;7(4):606-609. Epub 2019 Feb 22.

University Clinic of Dermatology, Ss. Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Giant Bowen's disease is a rare and unusual clinical manifestation. Presenting as extensive scaly erythematous patch or plaque, it gives rise to a wide spectrum of dermatological differential diagnoses.

Case Presentation: We report a patient with giant Bowen's disease on the face that was successfully treated with topical 5 % imiquimod. Read More

J Cosmet Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt.

Background: Few studies have evaluated facial photoaging by dermoscopy. Only one study has been performed among Egyptians.

Objective: To study and compare the dermoscopic features of facial aging in males and females and to relate these features to clinical criteria. Read More

Indian J Dermatol Venereol Leprol 2019 May-Jun;85(3):324-325

Department of Dermatology, Third People's Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

BMC Bioinformatics 2019 Mar 14;20(Suppl 2):91. Epub 2019 Mar 14.

Systems Engineering, University of Arkansas for Medical Sciences, 2804 S. University, Little Rock, 72204, AR, USA.

Background: Dermoscopy is one of the common and effective imaging techniques in diagnosis of skin cancer, especially for pigmented lesions. Accurate skin lesion border detection is the key to extract important dermoscopic features of the skin lesion. In current clinical settings, border delineation is performed manually by dermatologists. Read More

Expert Rev Anticancer Ther 2019 Mar 14:1-9. Epub 2019 Mar 14.

a Dermatology Unit , University of Campania Luigi Vanvitelli , Naples , Italy.

Introduction: The use of reflectance confocal microscopy (RCM) for imaging the skin non-invasively raised constantly during the last decade. One of the main field of application is skin cancer diagnosis, and in particular melanoma diagnosis. Several studies have investigated the diagnostic accuracy of RCM as compared to dermoscopic examination, and its value in enhancing early diagnosis of dermoscopic difficult melanomas. Read More

Skin Res Technol 2019 Mar 14. Epub 2019 Mar 14.

Stoecker and Associates, Rolla, Missouri.

Purpose: We present a classifier for automatically selecting a lesion border for dermoscopy skin lesion images, to aid in computer-aided diagnosis of melanoma. Variation in photographic technique of dermoscopy images makes segmentation of skin lesions a difficult problem. No single algorithm provides an acceptable lesion border to allow further processing of skin lesions. Read More

JAMA Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

Importance: It is challenging to differentiate melanoma from melanocytic nevus on the volar skin in the absence of typical dermoscopic patterns.

Objective: To identify the frequency and clinical and dermoscopic characteristics of melanocytic lesions on the volar skin not displaying a parallel furrow pattern, lattice-like pattern, fibrillar pattern, or parallel ridge pattern on results of dermoscopy.

Design, Setting, And Participants: In this retrospective cohort study, a total of 504 melanocytic lesions on the volar skin were evaluated in the Shinshu University Hospital department of dermatology between January 1, 2000, and December 31, 2012. Read More

Lasers Surg Med 2019 Mar 12. Epub 2019 Mar 12.

Klinika Ambroziak, Warsaw, Poland.

Objective: We wanted to evaluate dermoscopy as a tool to predict the efficacy of port-wine stain (PWS) laser treatment.

Study Design And Methods: Large spot 532 nm laser was used for the treatment of 67 PWS. Efficacy was assessed with an objective 3D digital imaging analysis. Read More