1,009,068 results match your criteria Dermatosis Papulosa Nigra


Genes known to escape X chromosome inactivation predict co-morbid chronic musculoskeletal pain and posttraumatic stress symptom development in women following trauma exposure.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 11. Epub 2018 Dec 11.

Institute for Trauma Recovery, University of North Carolina, Chapel Hill, North Carolina.

Co-morbid chronic musculoskeletal pain (CMSP) and posttraumatic stress symptoms (PTSS) are frequent sequelae of motor vehicle collision, are associated with greater disability than either outcome alone, and are more prevalent in women than men. In the current study we assessed for evidence that gene transcripts originating from the X chromosome contribute to sex differences in vulnerability to CMSP and PTSS after motor vehicle collision. Nested samples were drawn from a longitudinal study of African American individuals, and CMSP (0-10 numeric rating scale) and PTSS (impact of events scale, revised) outcomes were assessed 6 months following motor vehicle collision. Read More

View Article
December 2018
1 Read

CARD9 variants in Chinese patients with sporotrichosis.

J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China.

View Article
December 2018
1 Read

Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

View Article
December 2018
1 Read

Cellular and Chemical Gradients to Engineer the Meniscus-to-Bone Insertion.

Adv Healthc Mater 2018 Dec 10:e1800806. Epub 2018 Dec 10.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14850, USA.

Tissue-engineered menisci hold promise as an alternative to allograft procedures but require a means of robust fixation to the native bone. The insertion of the meniscus into bone is critical for meniscal function and inclusion of a soft tissue-to-bone interface in a tissue engineered implant can aid in the fixation process. The native insertion is characterized by gradients in composition, tissue architecture, and cellular phenotype, which are all difficult to replicate. Read More

View Article
December 2018
1 Read

How often are bath emollients prescribed to children with atopic eczema in primary care in England? A cross-sectional study.

Br J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Centre of Evidence Based Dermatology, University of Nottingham, King's Meadow Campus, Lenton Lane, Nottingham, NG7 2NR.

Atopic eczema is one of the most burdensome skin diseases across the globe and affects up to 20% of children in the UK. The mainstay of treatment is regular use of emollients including leave-on emollients, soap substitutes and emollient bath additives. However, the lack of evidence to support the use of bath additives has led some to question their role in atopic eczema management. Read More

View Article
December 2018
1 Read

JAK Inhibitors for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 5 E. 98th Street, New York, NY, 10029, USA.

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying degrees of Th1 and Th17 among various subtypes. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and spleen tyrosine kinase (SYK) pathways are involved in signaling of several AD-related cytokines, such as IFN-γ, IL-4, IL-13, IL-31, IL-33, IL-23, IL-22, and IL-17, mediating downstream inflammation and barrier alterations. Read More

View Article
December 2018
1 Read

Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis.

Dermatol Ther (Heidelb) 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Introduction: Erysipelas and bacterial cellulitis are two of the most common infectious skin diseases. They are usually caused by the β-hemolytic group of Streptococcus, and less frequently by other bacteria. The objective of the study was to assess the factors affecting the length of stay of patients admitted to hospital with erysipelas or bacterial cellulitis. Read More

View Article
December 2018
1 Read

Multifaceted activities of DNA polymerase η: beyond translesion DNA synthesis.

Curr Genet 2018 Dec 8. Epub 2018 Dec 8.

Laboratory of Genomic Instability and Diseases, Department of Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, 751023, India.

DNA polymerases are evolved to extend the 3'-OH of a growing primer annealed to a template DNA substrate. Since replicative DNA polymerases have a limited role while replicating structurally distorted template, translesion DNA polymerases mostly from Y-family come to the rescue of stalled replication fork and maintain genome stability. DNA polymerase eta is one such specialized enzyme whose function is directly associated with casual development of certain skin cancers and chemo-resistance. Read More

View Article
December 2018
1 Read

Side effects of frequently used oral antidiabetics on wound healing in vitro.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Institute of Translational Wound Research, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453, Witten, Germany.

Lifestyle diseases such as diabetes and arteriosclerosis are rising in the increasingly aging society, and the number of patients with daily intake of glucose-lowering medication has also increased. Interestingly, knowledge about oral antidiabetics with regard to wound healing is scarce. Therefore, the aim of this study was to identify possible (side) effects of the most frequently prescribed oral antidiabetics on skin cells and wound healing. Read More

View Article
December 2018
1 Read

Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia Evaluated Using Aggregated N-of-1 Trials.

JAMA 2018 Dec;320(22):2344-2353

Department of Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.

Importance: In rare diseases it is difficult to achieve high-quality evidence of treatment efficacy because of small cohorts and clinical heterogeneity. With emerging treatments for rare diseases, innovative trial designs are needed.

Objective: To investigate the effectiveness of mexiletine in nondystrophic myotonia using an aggregated N-of-1 trials design and compare results between this innovative design and a previously conducted RCT. Read More

View Article
December 2018

Persistent upregulation of the β-tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle.

Hum Mol Genet 2018 Dec 6. Epub 2018 Dec 6.

Light Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.

In healthy adult skeletal muscle fibers microtubules form a three-dimensional grid-like network. In the mdx mouse, a model of Duchenne muscular dystrophy (DMD), microtubules are mostly disordered, without periodicity. These microtubule defects have been linked to the mdx mouse pathology. Read More

View Article
December 2018

Comparison of microbiota and allergen profile in house dust from homes of allergic and non-allergic subjects- results from the GUSTO study.

World Allergy Organ J 2018 5;11(1):37. Epub 2018 Dec 5.

1Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.

Background: The prevalence of allergic diseases, such as asthma, allergic rhinitis, eczema and food allergy, has been increasing worldwide, as shown in a large number of studies, including the International Study of Asthma and Allergies in Childhood (ISAAC). However, there is significant variation in the prevalence of these diseases in different regions, suggesting that there may be location-specific factors such as environment and microbial exposure affecting allergic disease prevalence. Hence, in this study we determine if there is a difference in microbiota composition and allergen concentration of household dust collected from the homes of non-allergic and allergic subjects from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort. Read More

View Article
December 2018

Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages.

J Inflamm (Lond) 2018 4;15:25. Epub 2018 Dec 4.

1Department of Forensic Pathology, China Medical University School of Forensic Medicine, No.77, Puhe Road, Shenyang North New Area, Shenyang, 110122 Liaoning Province People's Republic of China.

Background: The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by regulating macrophage polarisation. Several research findings suggested that the activation of CB2R could attenuate inflammation by reducing pro-inflammatory M1 macrophage polarisation and promoting anti-inflammatory M2 polarisation. Read More

View Article
December 2018

A case of a patient with severe epidermolysis bullosa surviving to adulthood.

Int J Gen Med 2018 15;11:413-421. Epub 2018 Nov 15.

Department of Skin and Venereal Diseases, I.M. Sechenov First Moscow State Medical University, Moscow, Russia,

Purpose: The aim of this study was to evaluate the progression of a case of a patient with epidermolysis bullosa (EB) since early age who survived to adulthood, presenting with recurrent skin blisters and disfiguring scars and disabling musculoskeletal deformities.

Background: EB is a rare group of inherited diseases that affect the skin fragility causing it to blister in response to even minor trauma. Established novel treatments are limited in the literature due to its rarity, and more research is needed to set a global management approach. Read More

View Article
November 2018

Asymptomatic carriage of Streptococcus pneumoniae detected by qPCR on the palm of hands of populations in rural Senegal.

PLoS Negl Trop Dis 2018 Dec 10;12(12):e0006945. Epub 2018 Dec 10.

Aix-Marseille Univ, IRD, AP-HM, SSA, IHU-Méditerranée Infection, UMR Vecteurs-,InfectionsTropicales et Mediterranéennes (VITROME), Marseille, France.

Aside from malaria, infectious diseases are an important cause of death in sub-Saharan Africa and continue to pose major public health problems in African countries, notably pneumonia. Streptococcus pneumoniae remains the most common bacterial cause of pneumonia in all age groups. The skin is one of the main infection sites followed by the oropharynx. Read More

View Article
December 2018

[Discrasia linfoide epiteliotrópica de células T. Tratamiento con radiación ultravioleta].

Gac Med Mex 2018 ;154(Supp 2):S41-S49

Unidad de Fototerapia. Hospital General Dr. Manuel Gea González, Ciudad de México, México.

Introduction: T-cell lymphoid dyscrasia is a group of different, infrequent, epitheliotropic inflammatory dermatosis that precede cutaneous T-cell lymphomas. Treatment with ultraviolet radiation is safe and efficacious.

Objective: To describe responses to treatment, secondary effects and complications. Read More

View Article
January 2018

Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies.

J Vet Med Sci 2018 Dec 7. Epub 2018 Dec 7.

Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University.

In the present study, follicle-sinus complexes (FSCs) were harvested from the muzzle skin of 123 dogs with suspected canine rabies, and the sensitivity and specificity of FSC analysis were compared with those of brain tissue immunohistochemistry analysis. In the FSCs, viral antigen was detected from Merkel cells. Sensitivity was 97. Read More

View Article
December 2018

Real-life experience with ceftolozane/tazobactam in patients with hematologic malignancy and infection: a case-control study.

Antimicrob Agents Chemother 2018 Dec 10. Epub 2018 Dec 10.

Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain.

Background: We present our experience in patients with hematologic malignancy and infection treated with ceftolozane-tazobactam.

Materials/methods: We performed a single-center case-control study including all patients with hematologic malignancy and infection treated with ceftolozane-tazobactam (study group) and compared them with similar patients not treated with ceftolozane-tazobactam (control group) to assess safety and efficacy.

Results: Nineteen cases and 38 controls were analyzed. Read More

View Article
December 2018

Desmogleins as signaling hubs regulating cell cohesion and tissue/organ function in skin and heart- EFEM lecture 2018.

Authors:
Jens Waschke

Ann Anat 2018 Dec 7. Epub 2018 Dec 7.

Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Pettenkoferstr. 11, 80336 Munich, Germany. Electronic address:

Cell-Cell contacts are crucial for intercellular cohesion and formation of endothelial and epithelial barriers. Desmosomes are the adhesive contacts providing mechanical strength to epithelial intercellular adhesion and therefore are most abundant in tissues subjected to high mechanical stress such as the epidermis and heart muscle. Desmogleins (Dsg) besides intercellular adhesion serve as signalling hubs regulating cell behaviour. Read More

View Article
December 2018

Evaluation of the possible use of genus Mentha derived essential oils in the prevention of SENLAT syndrome caused by Rickettsia slovaca.

J Ethnopharmacol 2018 Dec 5. Epub 2018 Dec 5.

Biomedical Research Center, Institute of Virology, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia.

Ethnopharmacological Relevance: Essential oils and essential oil bearing medicinal and culinary plants have a long tradition of being used to combat infection, treat various conditions, and promote and restore health. Mint oils are traditionally applied to repel insects and treat various conditions including wounds, skin infections, inflammation, eczema, urticaria, psoriasis, scabies and insect bites. They are among essential oils promoted as a natural way to prevent tick-borne diseases and recommended as ingredients in various homemade repellent mixtures and tick-bite treatments. Read More

View Article
December 2018

Decorin counteracts disease progression in mice with recessive dystrophic epidermolysis bullosa.

Matrix Biol 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Molecular and Cell Biology, IDI-IRCCS, Rome, Italy. Electronic address:

Loss-of-function mutations in the gene encoding type VII collagen underlie recessive dystrophic epidermolysis bullosa (RDEB), a disease characterized by skin and mucosal blistering, impaired wound healing, and diffuse dermal inflammation and fibrosis. Transforming growth factor-β signaling plays a crucial role in determining RDEB fibrotic microenvironment that leads to the development of disabling secondary disease manifestations, including hand and foot deformities. Experimental findings indicate that expression levels of decorin, a small leucine-rich proteoglycan and an endogenous TGF-β inhibitor, can modulate RDEB disease phenotype by contrasting dermal fibroblast fibrotic behavior. Read More

View Article
December 2018
1 Read

Micro-scaled topographies direct differentiation of human epidermal stem cells.

Acta Biomater 2018 Dec 5. Epub 2018 Dec 5.

Centre for Stem Cells and Regenerative Medicine, King's College London, 28th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom. Electronic address:

Human epidermal stem cells initiate terminal differentiation when spreading is restricted on ECM-coated micropatterned islands, soft hydrogels or hydrogel-nanoparticle composites with high nanoparticle spacing. The effect of substrate topography, however, is incompletely understood. To explore this, primary human keratinocytes enriched for stem cells were seeded on a topographical library with over 2000 different topographies in the micrometre range. Read More

View Article
December 2018

The influence of interferon on healthy and diseased skin.

Cytokine 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Read More

View Article
December 2018

The Skin Bridge Is More Important as an Additional Venous Draining Route in a Perforator-Plus Flap.

J Surg Res 2019 Feb 27;234:40-48. Epub 2018 Sep 27.

Fujian Key Laboratory of Brain Aging and Neurodegenerative Diseases, Department of Human Anatomy and Embryology, Fujian Medical University, Fuzhou, Fujian, China. Electronic address:

Background: The skin bridge in the perforator-plus flap is considered as an additional source for arterial input and venous drainage apart from the perforator. However, its exact role requires further elucidation.

Materials And Methods: Forty rats that underwent flap elevation with a size of 9 × 3 cm on the dorsum were evenly divided into a perforators-intact group with an intact vascular pedicle, an artery-deficient group with the artery ligated, a vein-deficient group with the vein ligated, and a perforators-deficient group with both vessels ligated. Read More

View Article
February 2019

Consensus Statement on the Psychological Needs of Patients With Chronic Inflammatory Skin Diseases.

Actas Dermosifiliogr 2018 Dec 5. Epub 2018 Dec 5.

Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España.

Objective: To establish recommendations to determine, identify, and manage the psychological and emotional needs of patients with chronic inflammatory skin diseases in clinical practice.

Methods: A guided discussion was held at meeting of a nominal group of expert dermatologists and psychologists on the psychological and emotional needs of patients with chronic inflammatory skin diseases, how to manage these cases, and which referral criteria to employ. Based on the results of the discussion, and with the aid of a patient focus group and a review of the literature, a master document was drawn up with recommendations for discussion. Read More

View Article
December 2018

Safety and efficacy at 240 weeks of different raltegravir formulations in children with HIV-1: a phase 1/2 open label, non-randomised, multicentre trial.

Lancet HIV 2018 Dec;5(12):e715-e722

Department of Pediatrics, Jacobi Medical Center, New York, NY, USA.

Background: Raltegravir is an integrase inhibitor approved for use in adults and children with HIV-1 infection, but there are no data on the long-term use of this medication in children. We aimed to assess the long-term safety, tolerability, pharmacokinetics, and efficacy of multiple raltegravir formulations in children aged 4 weeks to 18 years with HIV-1 infection.

Methods: In this phase 1/2 open-label multicentre trial (IMPAACT P1066), done in 43 IMPAACT network sites in the USA, South Africa, Brazil, Botswana, and Argentina, eligible participants were children aged 4 weeks to 18 years with HIV-1 infection who had previously received antiretroviral therapy (ART), had HIV-1 RNA higher than 1000 copies per mL, and no exposure to integrase inhibitors. Read More

View Article
December 2018

Sirtuin signaling in cellular senescence and aging.

BMB Rep 2018 Dec 11. Epub 2018 Dec 11.

Department of Biological Sciences, Inha University, Incheon 22212, Korea.

Sirtuin is an essential factor that delays cellular senescence and extends the organismal lifespan through the regulation of diverse cellular processes. Suppression of cellular senescence by Sirtuin is mainly mediated through delaying the age-related telomere attrition, sustaining genome integrity and promotion of DNA damage repair. In addition, Sirtuin modulates the organismal lifespan by interacting with several lifespan regulating signaling pathways including insulin/IGF-1 signaling pathway, AMP-activated protein kinase, and forkhead box O. Read More

View Article
December 2018

[Ataxia telangiectasia. A prototype of neurological involvement in primary immune deficiencies].

Authors:
Zoltán Liptai

Orv Hetil 2018 Dec;159(49):2057-2064

Szent László Kórház Telephely, Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet Budapest, Albert Flórián út 5-7., 1097.

The number of primary immune deficiencies exceeds 350, approximately a quarter of them having neurological implications. Severe central nervous system infections may occur in an even higher proportion. Beyond listing in a table of all diseases with a neurological impact, the author gives detailed analysis of one typical disorder. Read More

View Article
December 2018

CD30+ T-cell lymphoproliferative disorders.

Chin Clin Oncol 2018 Oct 11. Epub 2018 Oct 11.

Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

The term "CD30+ T-cell lymphoproliferative disorders" describes a group of diverse diseases of the skin, subcutaneous tissues and mucosa that range from lesions requiring clinical observation to those necessitating systemic cytotoxic chemotherapy. Careful consideration of both clinical and histopathologic presentation is needed for appropriate diagnosis and treatment. This review will present the current classification of these disorders and potential treatment paradigms. Read More

View Article
October 2018

Genus Psoralea A review of the traditional and modern uses, phytochemistry and pharmacology.

J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.

CSIR-National Botanical Research Institute, Plant Transgenic Laboratory, P.O. Box 436, Rana Pratap Marg,Lucknow-226 001, U.P., India. Electronic address:

Ethnopharmacological Relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. Read More

View Article
December 2018
8 Reads

First ethnobotanical inventory and phytochemical analysis of plant species used by indigenous people living in the Maromizaha forest, Madagascar.

J Ethnopharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Agriculture, Forestry and Food Science, University of Torino, Torino, Italy.

Ethnopharmacological Relevance: Characterized by one of the highest rates of endemism and biodiversity in the world, Madagascar provides a wide variety of medicinal plants, that could represent a potential source of new drugs. The main aim of this study was to investigate the potential medicinal properties of the plant species used by indigenous people in Maromizaha forest and to provide the first ethnobotanical inventory of the area.

Materials And Methods: Data were collected through open semi-structured interviews with local informants, the reported plants were collected and identified to create a specimen herbarium. Read More

View Article
December 2018
6 Reads

Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

LAQV-REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Portugal, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.

In this study, fucoidan/chitosan nanoparticles were developed for the topical delivery of methotrexate towards the treatment of skin-related inflammatory diseases. Based on the fucoidan/chitosan (F/C) weight ratio, three different nanoparticles (1F/1C; 3F/1C; 5F/1C) were produced and characterized. Methotrexate was loaded in these polymeric nanoparticles achieving a drug loading of ca. Read More

View Article
December 2018
2 Reads

Age trends in asymptomatic and symptomatic Leishmania donovani infection in the Indian subcontinent: A review and analysis of data from diagnostic and epidemiological studies.

PLoS Negl Trop Dis 2018 Dec 6;12(12):e0006803. Epub 2018 Dec 6.

Zeeman Institute, University of Warwick, Coventry, United Kingdom.

Background: Age patterns in asymptomatic and symptomatic infection with Leishmania donovani, the causative agent of visceral leishmaniasis (VL) in the Indian subcontinent (ISC), are currently poorly understood. Age-stratified serology and infection incidence have been used to assess transmission levels of other diseases, which suggests that they may also be of use for monitoring and targeting control programmes to achieve elimination of VL and should be included in VL transmission dynamic models. We therefore analysed available age-stratified data on both disease incidence and prevalence of immune markers with the aim of collating the currently available data, estimating rates of infection, and informing modelling and future data collection. Read More

View Article
December 2018
2 Reads

Antibiotic allergy labels in hospitalised and critically ill adults: a review of current impacts of inaccurate labelling.

Br J Clin Pharmacol 2018 Dec 6. Epub 2018 Dec 6.

Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia.

Antibiotic Allergy Labels (AAL) are reported by approximately 20% of hospitalised patients, yet over 85% will be negative on formal allergy testing. Hospitalised patients with an AAL have inferior patient outcomes, increased colonization with multidrug resistant organisms and frequently receive inappropriate antimicrobials. Hospitalised populations have been well studied, yet to date the impact of AALs on patients with critical illness remain less well defined. Read More

View Article
December 2018
2 Reads

The Prevalence of Atopic Dermatitis and Chronic Spontaneous Urticaria are Associated with Parental Socioeconomic Status in Adolescents in China.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Xiangya Hospital, 410008 Changsha, China.

The association of atopic dermatitis and chronic spontaneous urticaria with socioeconomic status has been little studied. The aim of this study was to investigate the prevalence of skin diseases and their association with socioeconomic status in adolescents in China. A cross-sectional study was conducted at a comprehensive university. Read More

View Article
December 2018
3 Reads

Out-of-pocket Costs for Individuals with Atopic Eczema: A Cross-sectional Study in Nine European Countries.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology and Allergy, Technical University Munich, Biedersteinerstrasse 29, DE-80802 Munich, Germany.

Atopic eczema (AE) is one of the most common non-communicable inflammatory skin diseases, and has a huge socioeconomic impact. Studies on the everyday economic impact of AE on patients, however, are limited. To estimate the annual extra out-of-pocket spending due to AE among patients in Europe, a cross-sectional study using computer-assisted phone interviewing of patients with AE was performed in 9 European countries. Read More

View Article
December 2018
3 Reads

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

View Article
December 2018
3 Reads

Systemic therapies of pityriasis rubra pilaris: a systematic review.

J Dtsch Dermatol Ges 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Venereology, and Allergology, University Medical Centre, Göttingen, Germany.

Pityriasis rubra pilaris (PRP) is a rare papulosquamous disorder. Treatment is challenging; the armamentarium consists of topical corticosteroids, phototherapy, classic systemic treatments such as retinoids or immunosuppressive drugs, and most recently biologicals. However, the relative effectiveness of therapies is unclear. Read More

View Article
December 2018

Dermoscopic follow-up of therapeutic response in mantle cell lymphoma with secondary involvement of the scalp.

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

The Department of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Gliwice, Poland.

The scalp is a potential location for both benign and malignant tumors. Lymphoproliferative diseases can involve the skin as a primary or secondary manifestation. Dermoscopy is a noninvasive diagnostic tool for rapid diagnosis, screening, and follow-up of the majority of skin tumors. Read More

View Article
December 2018
3 Reads

Work-related skin diseases of Santa Claus.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Dermatology Department, Allergology, and Venereology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

The health of Santa Claus (SC) and work-related risks have been discussed on very few occasions in the medical literature [1,2]. We believe that due to his unique line of work, the skin of SC is peculiarly at risk and SC may be exposed to various work-related cutaneous hazards (table 1). According to Finnish folklore, SC currently lives and mainly work during the year in Korvatunturi (literally "Ear fell") in Finnish Lapland [3]. Read More

View Article
December 2018
2 Reads

Brentuximab induced CD30+ cutaneous lymphoma responded to anti-PD1 treatment.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Department, Cutaneous Lymphoma Clinic, National& Kapodestrian University of Athens, Medical School, "A. Sygros" Hospital for skin diseases, Athens, Greece.

Over the last decade major efforts have been made for the optimization of immune-directed therapies against cancer. Regarding cutaneous lymphomas (CTCLs), brentuximab (BV) has been recently approved by FDA and EMA for the treatment of primary cutaneous anaplastic large cell lymphoma as well as CD30-expressing mycosis fungoides, based on the ALCANZA trial favorable results. Concurrently, immune checkpoint inhibition has been shown to be of great value in the treatment of solid tumors and with promising results in a range of hematologic malignancies, however relevant data concerning CTCLs' treatment remain inconclusive. Read More

View Article
December 2018
1 Read

European Surveillance System on Contact Allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis.

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.

Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.

Objective: To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Read More

View Article
December 2018
4 Reads

Metformin inhibits pro-inflammatory responses via targeting nuclear factor-κB in HaCaT cells.

Cell Biochem Funct 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Chinese PLA General Hospital & Medical School, Beijing, China.

Psoriasis is a prevalent, chronic inflammatory skin disease that arises from rapid and excessive growth of keratinocytes induced by abnormal inflammatory responses. Metformin is the first-line drug in type 2 diabetes and has been proven to possess significant anti-inflammatory effects in various diseases. In the present study, we examined the role of metformin in nuclear factor kappa B (NF-κB)-mediated inflammatory responses in HaCaT cells, a cell line for the keratinocyte. Read More

View Article
December 2018
3 Reads

Hidradenitis Suppurativa: Causes, Features, and Current Treatments.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):17-23. Epub 2018 Oct 1.

Drs. Vinkel and Thomsen are with the Department of Dermatology at Bispebjerg Hospital in Copenhagen, Denmark.

Hidradenitis suppurativa (HS), a relatively common and chronic inflammatory skin disorder. HS can have debilitating consequences if not diagnosed and treated appropriately. Clinically defined by recurrent, inflamed nodules in intertriginous regions (i. Read More

View Article
October 2018
2 Reads

Immunization of Experimental Dogs With Salivary Proteins From , Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against .

Front Immunol 2018 16;9:2558. Epub 2018 Nov 16.

Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Brazil.

Metacyclic promastigotes are transmitted by sand flies that inject parasites and saliva into the host's skin. Previous studies have demonstrated that DNA plasmids encoding salivary proteins LJM17 and LJL143, when used to immunize dogs, resulted in a systemic and local Th1 cell-mediated immunity that interfered in parasite survival . Here we evaluated the ability of these same salivary antigens to induce anti- immunity and to confer protection by immunizing dogs using a novel vaccination strategy more suitable for use in the field. Read More

View Article
November 2018
4 Reads

Cutaneous Ewing Sarcoma and Ewing Sarcoma of the Bone: Distinct Diseases.

Case Rep Oncol 2018 Sep-Dec;11(3):729-734. Epub 2018 Nov 12.

Kaiser Permanente, Los Angeles, California, USA.

Ewing sarcoma is an aggressive mesenchymal malignancy. It is the second most common bone tumor among children and adolescents and less commonly presents as a soft tissue or primary skin lesion. Cutaneous Ewing sarcoma has only been reported in case reports and case series. Read More

View Article
November 2018
1 Read

Anti-Centromere Antibody Positivity in a Patient with Generalized Morphea.

Case Rep Dermatol 2018 Sep-Dec;10(3):226-230. Epub 2018 Oct 18.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.

We report the case of a 45-year-old female with generalized morphea (GM), who exhibited positivity for the anti-centromere antibody (Ab). She frequently developed multiple sclerotic skin lesions, whose histological findings were compatible with morphea. She demonstrated favorable responses to topical and oral steroids. Read More

View Article
October 2018
2 Reads

Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques.

Clin Cosmet Investig Dermatol 2018 9;11:561-569. Epub 2018 Nov 9.

IGeneX Laboratories, Palo Alto, CA, USA.

Background: Morgellons disease (MD) is a skin condition associated with Lyme disease (LD) and tick-borne illness. Patients with this skin disorder experience ulcerative lesions that contain multicolored filamentous collagen and keratin inclusions. Infection with various species of and other tick-borne pathogens has been detected in tissue and body fluid specimens from MD patients. Read More

View Article
November 2018
2 Reads
  • Page 1 of 20182