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    Paraneoplastic Dermatomyositis Syndrome Presenting as Dysphagia.
    Gastroenterology Res 2017 Aug 31;10(4):251-254. Epub 2017 Aug 31.
    Department of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Academic Affiliate of The Icahn School of Medicine at Mount Sinai, Clinical Affiliate of The Mount Sinai Hospital, 121 Dekalb Avenue, Brooklyn, NY 11201, USA.
    Dermatomyositis (DM) is a rare autoimmune condition which predominantly affects females in the fifth and sixth decades of life. DM presents acutely or progressively as painless proximal skeletal muscle weakness and can be associated with a heliotropic rash around the eyes, and Gottron's papules on extensor surfaces of the hands. While the pathophysiology of DM is still unclear, abnormal T- and B-cell immune activity has been reported. Read More

    Juvenile Dermatomyositis: Key Roles of Muscle Magnetic Resonance Imaging and Early Aggressive Treatment.
    Actas Dermosifiliogr 2017 Sep 11. Epub 2017 Sep 11.
    Servicio de Dermatología, Hospital Universitario Son Espases, Palma de Mallorca, España.
    Juvenile dermatomyositis is a rare systemic connective tissue disease with onset during childhood. It presents clinically with proximal muscle weakness and characteristic skin involvement. Diagnosis is based on the Bohan and Peter criteria, though many authors are now substituting biopsy with muscle magnetic resonance imaging (MRI) for both diagnosis and follow-up. Read More

    A case of lipoatrophic diabetes induced by juvenile dermatomyositis.
    J Diabetes Investig 2017 Sep 12. Epub 2017 Sep 12.
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.
    Lipodystrophy is a rare condition that is often accompanied by one or more metabolic diseases. Here we report a case of lipoatrophic diabetes induced by juvenile dermatomyositis. Although pioglitazone was not effective for lowering blood glucose levels, our observation suggested that it improved liver function slightly. Read More

    Focal hyperkeratosis overlying the palmar faces of interphalangeal and metacarpophalangeal joints revealing a juvenile dermatomyositis.
    J Eur Acad Dermatol Venereol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Dermatology, University Hospital, FR-29609, Brest, France.
    Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin [1]. It is the commonest of the idiopathic inflammatory myopathies of childhood, comprising 85% of cases. It has an annual incidence estimated to range between 1. Read More

    Inflammatory myopathy associated with antimitochondrial antibodies: A distinct phenotype with cardiac involvement.
    Semin Arthritis Rheum 2017 Jun 13. Epub 2017 Jun 13.
    Department of Medicine, Division of Rheumatology, Johns Hopkins University, School of Medicine, Baltimore, MD. Electronic address:
    Objective: In the context of clinical evaluations performed on our prospective myositis cohort, we noted a striking association of severe cardiac disease in myositis patients with antimitochondrial antibodies. We sought to review all cases of antimitochondrial antibody (AMA) associated myositis in our cohort to describe the clinical features of this disease subset.

    Methods: We identified 7 patients with confirmed antimitochondrial antibodies who presented as an inflammatory myopathy. Read More

    Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis.
    Skin Appendage Disord 2017 Aug 29;3(3):119-124. Epub 2017 Mar 29.
    Department of Dermatology and Cutaneous Surgery, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico.
    Background: Scalp involvement is not directly evaluated in patients with dermatomyositis (DM). Therefore, the exact frequency of scalp dermatomyositis (SDM) and its clinical and trichoscopic characteristics have been poorly described.

    Objective: The aim of this study was to determine the frequency and clinical and dermoscopic features of SDM in patients diagnosed with DM. Read More

    Pulmonary arterial hypertension, a novelty in idiopathic inflammatory myopathies: insights and first experiences with vasoactive therapy.
    RMD Open 2017 9;3(1):e000331. Epub 2017 Jun 9.
    Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
    To characterise the different types of pulmonary hypertension (PH) among idiopathic inflammatory myopathy (IIM). A retrospective case series with assessment of PH by right heart catheterisation, extent of interstitial lung disease (ILD) and outcome of vasoactive therapy.The group of patients with IIM with PH (n=9) showed a median age at PH diagnosis of 62 years (IQR 48-71 years; eight women), seven diagnosed with polymyositis and two with dermatomyositis; median disease duration of 5. Read More

    [Manifestations of the connective tissue associated interstitial lung disease under high resolution computed tomography].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Aug;42(8):934-939
    Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To analyze the features of the connective tissue associated interstitial lung disease (CTD-ILD) by high resolution computed tomography (HRCT).
 Methods: A total of 127 patients with CTD-ILD, who were diagnosed by clinic laboratory examination and pathology in Xiangya Hospital of Central South University form September 2013 to September 2015, were enrolled for this study. Their lung features of HRCT imaging were retrospectively analyzed. Read More

    [EARLY DETECTION OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH AUTOIMMUNE DISEASES BY A NOVEL NONINVASIVE TECHNIQUE].
    Harefuah 2017 Jul(1):411-414
    The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
    Introduction: Atherosclerosis is emerging as one of the most important causes of morbidity and mortality among patients with different rheumatologic disease. Endothelial dysfunction may be an early sign of atherosclerosis.

    Objectives: To evaluate the occurrence of endothelial dysfunction in children with autoimmune diseases, including juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE) and dermatomyositis, using a novel noninvasive technique. Read More

    Dermatomyositis and Immune-Mediated Necrotizing Myopathies: A Window on Autoimmunity and Cancer.
    Front Immunol 2017 21;8:992. Epub 2017 Aug 21.
    Normandie University, UNIROUEN, INSERM, U1234, Rouen University Hospital, Department of Immunology, Rouen, France.
    Autoimmune myopathies (myositides) are strongly associated with malignancy. The link between myositis and cancer, originally noticed by Bohan and Peter in their classification in 1975 (1), has been evidenced by large population-based cohort studies and a recent meta-analysis. The numerous reports of cases in which the clinical course of myositis reflects that of cancer and the short delay between myositis and cancer onset support the notion that myositis may be an authentic paraneoplastic disorder. Read More

    [Neutrophil extracellular traps-induced endothelial cell damage in the pathogenesis of dermatomyositis-associated interstitial lung disease].
    Zhonghua Nei Ke Za Zhi 2017 Sep;56(9):650-654
    Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
    Objective: To explore the role of neutrophil extracellular traps (NETs)-induced endothelial cell damage in the pathogenesis of dermatomyositis (DM)-associated interstitial lung disease(ILD). Methods: Serum free DNA and krebs von den lungen-6 (KL-6) level were tested in healthy controls, dermatomyositis patients with or without interstitial lung disease (DM-ILD and DM-NILD). Subjects' peripheral blood neutrophils were stimulated with phorbol 12-myristate 13-acetate (PMA), then human umbilical vein endothelial cells (HUVECs) were co-cultured with NETs. Read More

    Altered chemokine receptor expression in the peripheral blood lymphocytes in polymyositis and dermatomyositis.
    Cytokine 2017 Aug 28. Epub 2017 Aug 28.
    Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang 110001, People's Republic of China. Electronic address:
    Objective: To examine the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis (DM).

    Methods: We used flow cytometry to measure the frequencies of chemokinereceptors CXCR3 and CCR4 expression in the CD4(+) or CD8(+) lymphocytes. Enzyme linked immunosorbent assays were also used to measure the concentrations of C-X-C motif chemokine 10 (CXCL10), thymus and activation regulated chemokine (TARC) and macrophage derived chemokine (MDC). Read More

    Mortality and prognostic factors in idiopathic inflammatory myositis: a retrospective analysis of a large multicenter cohort of Spain.
    Rheumatol Int 2017 Sep 2. Epub 2017 Sep 2.
    Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
    The present study was undertaken to assess mortality, causes of death, and associated prognostic factors in a large cohort of patients diagnosed with idiopathic inflammatory myositis (IIM) from Spain. A retrospective longitudinal study was carried out in 467 consecutive patients with IIM, identified from 12 medical centers. Patients were classified as primary polymyositis, primary dermatomyositis (DM), overlap myositis, cancer-associated myositis (CAM), and juvenile idiopathic inflammatory myopathies. Read More

    Intravenous immunoglobulins for treatment of connective tissue diseases in dermatology.
    Wien Med Wochenschr 2017 Sep 1. Epub 2017 Sep 1.
    Department of Dermatology and Venereology, Medical University of Sofia, 1st, 1431, Sofia, Bulgaria.
    Background: Connective tissue diseases are a heterogeneous group of autoimmune disorders affecting not only skin, but also various organs and systems. First-line treatment of connective tissue diseases is systemic steroids as monotherapy or combined with immunosuppressive drugs. Since intravenous immunoglobulins (IVIGs) have been found to be effective for various autoimmune dermatoses, their indications have expanded tremendously. Read More

    Myositis-associated Interstitial Lung Disease: Predictors of Failure of Conventional Treatment and Response to Tacrolimus in a US Cohort.
    J Rheumatol 2017 Sep 1. Epub 2017 Sep 1.
    From the Department of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama; Department of Internal Medicine, and Section of Pulmonary and Critical Care Medicine, and Section of Rheumatology, University of Chicago, Chicago, Illinois, USA. Dr. Dua serves on the advisory board for Genentech and Janssen. Dr. Strek has served as the PI for her institution for studies of therapy for idiopathic pulmonary fibrosis with Gilead, InterMune, and MedImmune. She has served as a member of the Data Safety Committee for Boehringer- Ingelheim. Dr. Vij has received grant funding from Genentech for the study of interstitial lung diseases. N. Sharma, MD, Assistant Professor of Medicine, Department of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M.S. Putman, MD, Internal Medicine Resident, Department of Internal Medicine, University of Chicago; R. Vij, MD, Clinical Associate of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago; M.E. Strek, MD, Professor of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago; A. Dua, MD, MPH, Assistant Professor of Medicine, Rheumatology Fellowship Program Director, Section of Rheumatology, University of Chicago. Address correspondence to Dr. N. Sharma, Department of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 1201 11th Ave. S, Suite 510, Birmingham, Alabama 35205-3410, USA. E-mail: Accepted for publication June 15, 2017.
    Objective: Patients with myositis-associated interstitial lung disease (MA-ILD) are often refractory to conventional treatment, and predicting their response to therapy is challenging. Recent case reports and small series suggest that tacrolimus may be useful in refractory cases.

    Methods: A retrospective cohort study of patients with MA-ILD comparing clinical characteristics between those who responded to or failed conventional treatment. Read More

    Facts and controversies in mixed connective tissue disease.
    Med Clin (Barc) 2017 Aug 29. Epub 2017 Aug 29.
    Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, España; Instituto de Investigación Biomédica Hospital Gregorio Marañón, Madrid, España; Universidad Complutense de Madrid, Madrid, España.
    Mixed connective tissue disease (MCTD) is a systemic autoimmune rheumatic disease (SARD) characterised by the combination of clinical manifestations of systemic lupus erythematosus (SLE), cutaneous systemic sclerosis (SSc) and polymyositis-dermatomyositis, in the presence of elevated titers of anti-U1-RNP antibodies. Main symptoms of the disease are polyarthritis, hand oedema, Raynaud's phenomenon, sclerodactyly, myositis and oesophageal hypomobility. Although widely discussed, most authors today accept MCTD as an independent entity. Read More

    Infections and respiratory tract disease as risk factors for idiopathic inflammatory myopathies: a population-based case-control study.
    Ann Rheum Dis 2017 Aug 30. Epub 2017 Aug 30.
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Objectives: To investigate the association between infection or respiratory tract disease and future risk of developing idiopathic inflammatory myopathy (IIM).

    Methods: A case-control study was performed using Swedish nationwide registers. Adults with newly diagnosed IIM were identified (2002-2011) from the National Patient Register (NPR) and the Swedish Rheumatology Register (n=957). Read More

    The EuroMyositis registry: an international collaborative tool to facilitate myositis research.
    Ann Rheum Dis 2017 Aug 30. Epub 2017 Aug 30.
    Department of Rheumatology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.
    Aims: The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.

    Methods: Cross-sectional analysis of IIM cases from 11 countries was performed. Read More

    Automated diagnosis of myositis from muscle ultrasound: Exploring the use of machine learning and deep learning methods.
    PLoS One 2017 30;12(8):e0184059. Epub 2017 Aug 30.
    Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
    Objective: To evaluate the use of ultrasound coupled with machine learning (ML) and deep learning (DL) techniques for automated or semi-automated classification of myositis.

    Methods: Eighty subjects comprised of 19 with inclusion body myositis (IBM), 14 with polymyositis (PM), 14 with dermatomyositis (DM), and 33 normal (N) subjects were included in this study, where 3214 muscle ultrasound images of 7 muscles (observed bilaterally) were acquired. We considered three problems of classification including (A) normal vs. Read More

    Muscle ultrasound: a potential tool for detecting of fasciitis among dermatomyositis and polymyositis: Comment on article by Yoshida et al.
    Arthritis Rheumatol 2017 Aug 29. Epub 2017 Aug 29.
    Department of Rheumatology, Radboud University Medical Center, Nijmegen.
    We read with interest the article by Yoshida and colleagues on the ability of muscle ultrasound for detecting of fasciitis among patients with dermatomyositis (DM) in the early phase of their disease (1). The authors used power Doppler ultrasonography to assess inflammation and vascularity of the fascia of different muscles. This article is protected by copyright. Read More

    Sex Differences in Pediatric Rheumatology.
    Clin Rev Allergy Immunol 2017 Aug 28. Epub 2017 Aug 28.
    Anna Meyer Children's Hospital and University of Florence, Viale Pieraccini 24, 50139, Florence, Italy.
    Autoimmune diseases affect up to 10% of the world's population and, as a whole, they are far more common in females, although differences exist according to the single disease and also in different age groups. In childhood-onset autoimmune diseases, the sex bias is generally less evident than in adults, probably for the different hormonal milieau, being estrogens strongly implicated in the development of autoimmunity. Still, some rheumatic conditions, such as juvenile idiopathic arthritis (JIA), show a strong predilection for girls (F:M = 3-6. Read More

    GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population.
    Genet Test Mol Biomarkers 2017 Sep 28;21(9):565-570. Epub 2017 Aug 28.
    1 Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital , Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China .
    Aim: Racial differences and genetic overlap have been shown to be responsible for the difference in susceptibility to dermatomyositis (DM)/polymyositis (PM) in a variety of populations. Single nucleotide polymorphisms (SNPs) in the GLI-similar 3 (GLIS3) and tyrosine kinase 2 (TYK2) genes have been associated with various autoimmune diseases. The aim of this study was to investigate whether SNPs in GLIS3 (rs7020673, rs10758593, and rs10814916) and TYK2 (rs280519, rs2304256, rs17000730, and rs280501) were associated with an increase in susceptibility to DM/PM in a Chinese Han population. Read More

    Neutrophil extracellular traps may contribute to interstitial lung disease associated with anti-MDA5 autoantibody positive dermatomyositis.
    Clin Rheumatol 2017 Aug 25. Epub 2017 Aug 25.
    Department of Rheumatology, West China Hospital, Sichuan University, No.37 Guoxue Lane, Chengdu, 610041, China.
    In dermatomyositis (DM), anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody (autoAb) marks a subtype with low grade or absent muscle inflammation but frequent and rapidly progressive interstitial lung disease (ILD). The pathogenesis of ILD remains poorly unknown. The aim of the study is to explore whether neutrophil extracellular traps (NETs) are involved in the development of ILD in DM patients with anti-MDA5 autoAb. Read More

    Cardiovascular involvement in myositis.
    Curr Opin Rheumatol 2017 Aug 24. Epub 2017 Aug 24.
    Department of Rheumatology, Odense University Hospital, Odense, Denmark.
    Purpose Of Review: The purpose of this review is to provide an update on cardiovascular involvement in idiopathic inflammatory myopathy (IIM). Studies from the past 18 months are identified and reviewed. Finally, the clinical impact of these findings is discussed. Read More

    Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis.
    Chin Med J (Engl) 2017 Sep;130(17):2101-2106
    Research Institute of Neuromuscular and Neurodegenerative Diseases, Department of Neurology, Qilu Hospital, Shandong University; Brain Science Research Institute, Shandong University, Jinan, Shandong 250012, China.
    Background: The immunopathologic mechanism underlying dermatomyositis (DM) and polymyositis (PM) remains poorly understood. Many cytokines play a pathogenic role in DM and PM. Interleukin 21 (IL-21) has a pleiotropic effect on inflammation regulation. Read More

    Multiple values of (18)F-FDG PET/CT in idiopathic inflammatory myopathy.
    Clin Rheumatol 2017 Aug 22. Epub 2017 Aug 22.
    Department of Nuclear Medicine, Peking University People's Hospital, 11th Xizhimen South St., Beijing, 100044, China.
    This study aimed to investigate the multiple values of (18)F-FDG PET/CT in detecting malignant tumors, evaluating myopathy, and determining interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM). We retrospectively analyzed the data of 38 patients who were examined by (18)F-FDG PET/CT and eventually diagnosed as IIM. We also collected the data of another 22 cases with negative PET/CT as the control. Read More

    Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study.
    PLoS One 2017 22;12(8):e0183292. Epub 2017 Aug 22.
    Research Center for Genetic Medicine, Children's National Health System, Washington, D.C., United States of America.
    Objective: To identify changes in skeletal muscle microRNA expression after endurance exercise and associate the identified microRNAs with mRNA and protein expression to disease-specific pathways in polymyositis (PM) and dermatomyositis (DM) patients.

    Methods: Following a parallel clinical trial design, patients with probable PM or DM, exercising less than once a week, and on stable medication for at least one month were randomized into two groups at Karolinska University Hospital: a 12-week endurance exercise group (n = 12) or a non-exercised control group (n = 11). Using an Affymetrix microarray, microRNA expression was determined in paired muscle biopsies taken before and after the exercise intervention from 3 patients in each group. Read More

    A Case of Dermatomyositis with Severe Myalgia and Muscle Weakness Testing Positive for Anti-melanoma Differentiation-associated Gene 5 Antibody.
    Acta Med Okayama 2017 Aug;71(4):341-344
    Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8557,
    We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Read More

    Hypoxia triggers IFN-I production in muscle: Implications in dermatomyositis.
    Sci Rep 2017 Aug 17;7(1):8595. Epub 2017 Aug 17.
    Neuromuscular Diseases Unit, Neurology Department, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Institut de Recerca Sant Pau, (Barcelona) and Biomedical Network Research Centre on Rare Diseases (CIBERER), Sant Pau, Spain.
    Dermatomyositis is an inflammatory myopathy characterized by symmetrical proximal muscle weakness and skin changes. Muscle biopsy hallmarks include perifascicular atrophy, loss of intramuscular capillaries, perivascular and perimysial inflammation and the overexpression of IFN-inducible genes. Among them, the retinoic-acid inducible gene 1 (RIG-I) is specifically overexpressed in perifascicular areas of dermatomyositis muscle. Read More

    Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study.
    Ann Rheum Dis 2017 Aug 16. Epub 2017 Aug 16.
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Patients with idiopathic inflammatory myopathies (IIMs) suffer an increased burden of comorbidities, but data on mortality in recently diagnosed IIM are conflicting. Also, little is known when, if ever, in relation to IIM diagnosis, mortality is increased.

    Methods: A population-based IIM cohort of patients diagnosed between 2002 and 2011 and general population comparators were identified using healthcare registers. Read More

    Microvascular Abnormalities Assessed by Nailfold Capillaroscopy In Juvenile Dermatomyositis After Medium to Long-Term Follow-Up.
    Arthritis Care Res (Hoboken) 2017 Aug 13. Epub 2017 Aug 13.
    Institute for Translational Medicine Medical School, University of Pécs, Pécs, Hungary.
    Objective: In juvenile dermatomyositis (JDM), microvascular abnormalities measured by nailfold capillaroscopy (NFC) are common early in disease course. We aimed to compare the presence of NFC abnormalities in patients with medium- to longstanding JDM with that of controls, and to explore associations between NFC abnormalities and disease activity and other disease characteristics.

    Methods: Fifty-eight JDM patients clinically examined median 16. Read More

    A Recurrent Episode of Dermatomyositis Associated with Papillary Thyroid Cancer.
    Case Rep Endocrinol 2017 19;2017:7985953. Epub 2017 Jul 19.
    Department of Endocrinology, Swedish American Hospital, 1253 N. Alpine Road, Rockford, IL 61107, USA.
    Objective: It is uncommon for dermatomyositis to be associated with papillary thyroid cancer. We report an unusual case of papillary thyroid cancer presenting with dermatomyositis.

    Methods: The case history, imaging and laboratory data is reviewed. Read More

    The role and mechanism of cathepsin G in dermatomyositis.
    Biomed Pharmacother 2017 Oct 8;94:697-704. Epub 2017 Aug 8.
    Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address:
    Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by CD4+ T cells and B cells infiltration in perivascular and muscle tissue. Although the infiltration of inflammatory cells plays a key role in muscle damage, the exact mechanism is not clear. Cathepsin G (CTSG) is a member of the serine proteases family and can increase the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Read More

    Superimposed Segmental Manifestation of Juvenile Amyopathic Dermatomyositis in a 9-year-old Boy.
    Indian J Dermatol 2017 Jul-Aug;62(4):440
    Department of Pathology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
    Dermatomyositis is a well-known autoimmune disorder. On the other hand, juvenile amyopathic dermatomyositis (JADM) occurs rather rarely. Here, we report an unusual case in a 9-year-old Turkish boy showing a unilateral linear inflammatory skin lesion that was followed, after 16 months, by the appearance of bilateral disseminated features JADM. Read More

    [EARLY DETECTION OF ENDOTHELIAL DYSFUNCTION IN CHILDREN WITH AUTOIMMUNE DISEASES BY A NOVEL NONINVASIVE TECHNIQUE].
    Harefuah 2017 Jul(1):411-414
    The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
    Introduction: Atherosclerosis is emerging as one of the most important causes of morbidity and mortality among patients with different rheumatologic disease. Endothelial dysfunction may be an early sign of atherosclerosis.

    Objectives: To evaluate the occurrence of endothelial dysfunction in children with autoimmune diseases, including juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE) and dermatomyositis, using a novel noninvasive technique. Read More

    Fosaprepitant for the Management of Refractory Pain in a Patient with Cancer-Related Dermatomyositis.
    J Palliat Med 2017 Aug 7. Epub 2017 Aug 7.
    1 Department of Medicine, Division of General Internal Medicine and Geriatrics, Medical University of South Carolina , Charleston, South Carolina.
    Objective: Optimal pain management often requires multiple pharmacological interventions with the goal of disrupting the pain-signaling pathway and targeting the underlying pathophysiology. Off label use of nonpain medications may have a role in treating refractory pain syndromes.

    Background: We report a case of a 60-year-old female with refractory nociceptive and neuropathic pain. Read More

    Efficacy of intralesional sodium thiosulfate injections for disabling tumoral calcinosis: Two cases.
    Semin Arthritis Rheum 2017 Jun 17. Epub 2017 Jun 17.
    Service de pédiatrie, Hopital de la Mère et de l'Enfant, Limoges, France. Electronic address:
    Introduction: Tumoral calcinosis (TC) is a difficult-to-treat complication that can occur during several diseases such as dermatomyositis or genetic hyperphosphatemia. It is a painful and disabling condition that can lead to local complications including joint mobility reduction, cutaneous ulceration and superinfection. For the largest lesions, the treatment relies essentially on surgery. Read More

    Using multi-omics methods to understand dermatomyositis/polymyositis.
    Autoimmun Rev 2017 Oct 1;16(10):1044-1048. Epub 2017 Aug 1.
    Department of Rheumatology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address:
    Idiopathic inflammatory myopathies (IIM) are a group of rare and heterogeneous autoimmune diseases, and the most common subtypes are dermatomyositis (DM) and polymyositis (PM). Despite extensive efforts, the underlying mechanism of IIM remains unclear. Recent efforts to understand the pathogenesis of IIM have included genomics, epigenetics, transcriptomics, proteomics and autoantibody studies. Read More

    First report of anti-TIF1γ dermatomyositis in a patient with myelodysplastic syndrome.
    Reumatismo 2017 Aug 3;69(2):75-77. Epub 2017 Aug 3.
    Experimental and Clinical Medicine Dept., University of Florence, Florence.
    Inflammatory myopathies as para-neoplastic phenomena were first described by Sterz in 1916. Recently, myositis specific autoantibodies were described in cancer-associated myositis. Anti-transcription intermediary factor 1 gamma (anti-TIF1γ) antibodies have been found in both young adults affected by juvenile dermatomyositis and in elderly patients with cancer-associated myositis. Read More

    Ultrasound in Arthritis.
    Radiol Clin North Am 2017 Sep 12;55(5):985-996. Epub 2017 Jun 12.
    Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Trust, Windmill Road, Oxford, OX3 7LD, UK.
    Ultrasound is currently performed in everyday rheumatologic practice. It is used for early diagnosis, to monitor treatment results, and to diagnose remission. The spectrum of pathologies seen in arthritis with ultrasound includes early inflammatory features and associated complications. Read More

    Multicentric Reticulohistiocytosis with Dermatomyositis-like Eruptions.
    Intern Med 2017 1;56(15):2063-2066. Epub 2017 Aug 1.
    Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Japan.
    A 68-year-old man presented with polyarthritis, proximal muscle weakness, and erythema of the face, arms, neck, and anterior chest that resembled the V-neck sign. Initially, dermatomyositis (DM) was considered because of the erythema, polyarthritis, and muscle weakness. He also had mediastinal and hilar lymphadenopathy on contrast-enhanced computed tomography. Read More

    Comparisons of neutrophil-, monocyte-, eosinophil-, and basophil- lymphocyte ratios among various systemic autoimmune rheumatic diseases.
    APMIS 2017 Oct 2;125(10):863-871. Epub 2017 Aug 2.
    Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China.
    This study was aimed to evaluate levels of neutrophil- (NLR), monocyte- (MLR), eosinophil- (ELR), and basophil-lymphocyte ratio (BLR) and their association with inflammatory markers in systemic autoimmune rheumatic diseases (SARDs). A total of 1139 SARD patients and 170 healthy individuals were enrolled. Clinical and laboratory data were extracted. Read More

    Endoscopy is of low yield in the identification of gastrointestinal neoplasia in patients with dermatomyositis: A cross-sectional study.
    World J Gastroenterol 2017 Jul;23(26):4788-4795
    Trilokesh D Kidambi, James W Ostroff, Jonathan P Terdiman, Jeffrey K Lee, Division of Gastroenterology, University of California, San Francisco, CA 94115, United States.
    Aim: To determine the prevalence of gastrointestinal neoplasia among dermatomyositis patients who underwent an esophagogastroduodenoscopy and/or colonoscopy.

    Methods: A cross-sectional study examining the results of upper endoscopy and colonoscopy in adults with dermatomyositis at an urban, university hospital over a ten year period was performed. Chart review was performed to confirm the diagnosis of dermatomyositis. Read More

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