9,956 results match your criteria Dermatomyositis
Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.
Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.
Objectives: To characterize the 10 year relationship between anti-transcriptional intermediary factor 1 antibody (anti-TIF1-Ab) positivity and cancer onset in a large UK-based adult DM cohort.
Methods: Data from anti-TIF1-Ab-positive/-negative adults with verified diagnoses of DM from the UK Myositis Network register were analysed. Each patient was followed up until they developed cancer. Read More
Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.
Department of Rheumatology and Immunology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Rom J Morphol Embryol 2018 ;59(3):977-983
Department of Plastic Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;
Basal cell carcinoma (BCC) is the most common type of cancer located in the periocular area. We will present the clinical case of a 63-year-old male patient who was admitted to the 2nd Clinic of Neurosurgery, "Prof. Dr. Read More
Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):65-68
Department of Paediatric, Paediatric Rheumatology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Mixed connective tissue disease (MCTD) or overlap syndrome is a rare disease. It has overlapping features of more than one autoimmune disease with high titer of anti-ribonucleoprotein antibodies against U1. We present a 12-year-old Saudi male patient who was presented to the dental clinic complaining from non-healing oral ulcers and multiple periapical abscesses that not responsive to extractions and the use of oral antibiotics, these symptoms were accompanied with persistent fever, headache, muscle weakness, general malaise, and painful bilateral cervical lymphadenopathy. Read More
Nihon Shokakibyo Gakkai Zasshi 2018 ;115(12):1063-1068
Department of Medical Oncology, Shizuoka General Hospital.
A 65-year-old woman who had been diagnosed with dermatomyositis presented to the hospital with a small bowel mass. She had tested positive for fecal occult blood test and anemia at a medical checkup;therefore, computerized tomography (CT) was performed at the previous hospital and it had revealed thickening of the intestinal wall. Abdominal contrast-enhanced CT, single-balloon assisted enteroscopy, and biopsy led to a diagnosis of poorly differentiated jejunal adenocarcinoma. Read More
Ann Rheum Dis 2018 Dec 8. Epub 2018 Dec 8.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
CMAJ 2018 Dec;190(49):E1453
Department of Medicine, University of Toronto, Toronto, Ont.
J Allergy Clin Immunol 2018 Dec 7. Epub 2018 Dec 7.
Institut National de la Santé et de la Recherche Médicale; Centre de Recherche des Cordeliers, Equipe-Immunopathologie et Immunointervention Thérapeutique; Sorbonne Université, Paris, F-75006, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, F-75006, France. Electronic address:
Background: Therapeutic normal immunoglobulin G or intravenous immunoglobulin (IVIG) exerts anti-inflammatory effects via several mutually nonexclusive mechanisms. Recent data in mouse models of autoimmune diseases suggest that IVIG induces IL-4 in basophils by enhancing IL-33 in SIGN-R1 innate cells. However, translational insight on these data is lacking. Read More
Rev Med Interne 2018 Dec 4. Epub 2018 Dec 4.
Service de médecine interne, hôpital de Bordeaux, hôpital Saint-André, 1, rue Jean-Burguet, 33000 Bordeaux, France; CNRS-UMR5164 immuno ConcEpT, université de Bordeaux, 33000 Bordeaux, France. Electronic address:
Introduction: Dermatomyositis are rare autoimmune diseases. The discovery of specific antibodies such as the anti-TIF1γ, anti-SAE1/2 and anti-NXP2 antibodies has been associated with specific clinical phenotypes. The recent development of standardized kits based on immunodot method is a progress in dermatomyositis diagnosis. Read More
Cytokine 2018 Dec 6. Epub 2018 Dec 6.
Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Read More
J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.
Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:
The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More
J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.
Dept. of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany.
Dermatomyositis (DM) is a connective tissue disease with rare incidence, characterized by progressive muscle weakness and typical cutaneous manifestations. Its pathogenesis is still incompletely understood, but next to genetic predisposition environmental factors seem to be implicated in the development of DM (1). Photosensitivity is one important factor for the onset and exacerbation of DM, which is corroborated by the distribution of the cutaneous features on sun-exposed areas and disease photoaggravation (2,3). Read More
Rheumatol Int 2018 Dec 5. Epub 2018 Dec 5.
Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Recent studies have shown a high prevalence of dyslipidemia in patients with systemic autoimmune myopathies (SAM). However, little is known about the safety of the use of statins in these patients, and this gap in research motivated the accomplishment of the present study. In a retrospective cohort study conducted from 2004 to 2018, 250 patients with SAM were evaluated, and 24 patients had stable forms of SAM (16 dermatomyositis, 1 polymyositis and 7 antisynthetase syndrome) but had dyslipidemia and had received statins. Read More
Br J Dermatol 2018 Dec;179(6):1233-1234
Cardiff Regional Experimental Arthritis Treatment and Evaluation Centre (CREATE), Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, U.K.
Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.
Department of Rheumatology, Oslo University Hospital, Rikshospitalet.
Objectives: To compare cardiorespiratory fitness (CRF) expressed as maximal oxygen uptake (VO2max) between patients with long-term JDM and controls and between patients with active and inactive disease, as well as to explore exercise limiting factors and associations between CRF and disease variables.
Methods: JDM patients (n = 45) and age- and gender-matched controls (n = 45) performed a cardiopulmonary exercise test (CPET) on a treadmill until exhaustion. Physical activity was measured by accelerometers. Read More
Clin Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.
Department of Dermatology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK.
Scand J Rheumatol 2018 Dec 5:1-5. Epub 2018 Dec 5.
a Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.
Objective: Dermatomyositis (DM) is an idiopathic inflammatory myopathy which often involves the lungs. DM is likely to be associated with aberrant T- and B-cell activation in the pathogenesis because of the proven effectiveness of T- and B-cell-targeted treatments. Assuming that the aberrant activation is reflected by biases in the lymphocyte subset repertoires, we aimed to elucidate these biases, especially in relation to clinical features of DM. Read More
Case Rep Rheumatol 2018 1;2018:7384681. Epub 2018 Nov 1.
Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Clinically amyopathic dermatomyositis (CADM) is a rare disease with unknown origin. It is characterized by the specific skin lesions of dermatomyositis (DM) without clinical or laboratory evidence of myopathy. Previous studies indicated that tattoo may induce immune response. Read More
Zhonghua Nei Ke Za Zhi 2018 Dec;57(12):938-941
Mod Rheumatol 2018 Nov 28:1-20. Epub 2018 Nov 28.
a Institute of Rheumatology, Tokyo Women's Medical University , Tokyo , Japan.
Objectives: We aimed to evaluate the usefulness of serum KL-6 for interstitial lung disease (ILD) with polymyositis/dermatomyositis (PM/DM).
Methods: All consecutive and previously untreated adult patients with PM/DM who were admitted to our hospital from 2010 to 2015 were included. The associations between serum KL-6 levels and clinical information were retrospectively analyzed. Read More
Case Rep Gastroenterol 2018 Sep-Dec;12(3):622-628. Epub 2018 Oct 23.
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Dermatomyositis (DM) is often found in conjunction with malignant tumors such as lung, cervical, and breast cancer. However, the association with intrahepatic cholangiocarcinoma (ICC) is extremely rare. Moreover, to our knowledge, there have been no previous reports of DM discovered because of exacerbation of DM. Read More
Semin Arthritis Rheum 2018 Nov 2. Epub 2018 Nov 2.
Penn State Hershey Medical Center, Department of Dermatology, 500 University Drive, Hershey, PA, USA. Electronic address:
Background: Dermatomyositis (DM) is associated with malignancy and interstitial lung disease. Many malignancies associated with DM occur in organs not routinely screened by national guidelines; thus, best screening practices are still debated. Positron emission tomography (PET) has been suggested as a single study alternative to more complex screening panels and may also be valuable in detecting interstitial lung disease progression. Read More
Dermatol Clin 2019 Jan 1;37(1):37-48. Epub 2018 Nov 1.
Departments of Dermatology and Pathology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue A61, Cleveland, OH 44195, USA. Electronic address:
Connective tissue diseases often prominently affect the skin, requiring dermatologists to play an important role in diagnosis and treatment of these patients. Herein we describe updates on the pathogenesis, clinical features, and treatment of 4 major connective tissue diseases: dermatomyositis, cutaneous lupus erythematosus, limited scleroderma (morphea), and cutaneous vasculitis. Many of these updates promise to improve clinical care of patients who suffer from dermatologic involvement of these diseases and are the result of research performed by dermatologists who have expertise in these conditions. Read More
Am J Health Syst Pharm 2018 Dec;75(23):1883-1888
Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, Mayo Clinic Rochester, Rochester, MN.
Purpose: The effect of therapeutic plasma exchange (TPE) on antifactor Xa activity in a patient treated with enoxaparin and levetiracetam is reported.
Summary: A 52-year-old woman was treated with levetiracetam and prophylactic enoxaparin while receiving TPE to manage respiratory failure due to anti-MDA5 antibody-associated interstitial lung disease (ILD) with dermatomyositis. Due to a scant amount of evidence regarding the management of these medications in TPE, therapeutic monitoring principles were used to assess the effect TPE had on these medications. Read More
Acta Derm Venereol 2018 Nov 21. Epub 2018 Nov 21.
Department of Dermatology, Saint-Eloi Hospital and Montpellier University Hospital, 34295 Montpellier, France.
Anti-transcriptional intermediary factor-1γ (TIF-1γ) autoantibody may be associated with cancer in adult patients with dermatomyositis. The aim of this study was to evaluate the risk of cancer in the presence of anti-TIF-1γ autoantibody in adult dermatomyositis. A comprehensive database search of EMBASE, MEDLINE and the Cochrane Library up to May 2018 was performed using the main key words "dermatomyositis", "myositis", "inflammatory myopathies" and "anti-TIF-1". Read More
Pediatr Rheumatol Online J 2018 Nov 20;16(1):72. Epub 2018 Nov 20.
Division of Rheumatology and Immunology, The Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing, 100020, China.
Objective: To follow up the refractory juvenile dermatomyositis (JDM) with autologous hematopoietic stem cell transplantation (AHSCT) in a long time and to investigate whether AHSCT is effective and safe to treat refractory JDM.
Methods: We collected the AHSCT and follow-up data of three patients with refractory JDM who received autologous peripheral blood CD34+ cell transplantation in our hospital between June 2004 and July 2015. Those data include: hight, weight, routine blood and urine tests, ESR, CK, ALT, AST, LDH, renal functional tests, lymphocyte subpopulations, HRCT and muscle MRI. Read More
J Am Acad Dermatol 2018 Nov 17. Epub 2018 Nov 17.
Department of Rheumatology, Mayo Clinic, Jacksonville, FL.
Background: The clinical significance of antinuclear antibody (ANA) status in adults with dermatomyositis (DM) has yet to be fully defined.
Objective: We compared the incidence of amyopathic disease, risk of malignancy, and clinical findings in ANA-positive and ANA-negative patients with adult-onset DM.
Methods: This was a retrospective cohort study of patients with ANA-positive or ANA-negative adult-onset DM determined by enzyme-linked immunosorbent assay. Read More
Balkan Med J 2018 11 20. Epub 2018 Nov 20.
Department of Internal Medicine, Division of Allergy, Immunology and Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan
JAAD Case Rep 2018 Nov 10;4(10):1049-1051. Epub 2018 Nov 10.
Department of Dermatology, University of California, San Francisco, San Francisco, California.
Scand J Immunol 2018 Nov 19:e12732. Epub 2018 Nov 19.
Division of Rheumatology, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden.
We aimed to evaluate in vivo effects of abatacept on phenotypes of T and B cells in the circulation of myositis patients in a sub-study of the ARTEMIS trial. Twelve patients with paired frozen PBMCs before and after 6-month abatacept treatment were included in this sub-study where mass cytometry (CyTOF) was chosen as a technology to be tested for its utility in a real-life clinical immune monitoring setting. Using CyTOF, the peripheral T cell phenotypes demonstrated considerable variation over time and between individuals precluding the identification of treatment-specific changes. Read More
Intern Med 2018 Nov 19. Epub 2018 Nov 19.
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). We herein report three Japanese cases of anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM. High-resolution computed tomography revealed patchy or subpleural distribution of consolidations and/or ground-glass opacities accompanied by traction bronchiectasis. Read More
Mod Rheumatol 2018 Nov 19:1-17. Epub 2018 Nov 19.
a Division of Rheumatology, Department of Internal Medicine , Hyogo College of Medicine , Hyogo , Japan.
Objective: This study identified biomarkers that can be used to assess disease activity and response to therapy in patients with interstitial lung disease complicating anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab)-positive clinically amyopathic dermatomyositis (CADM).
Methods: In 15 patients with interstitial lung disease complicating anti-MDA5 Ab-positive CADM, anti-MDA5 Ab, neopterin, interleukin (IL)-18, ferritin, and soluble interleukin 2 receptor (sIL-2R) levels were measured in cryopreserved serum specimens before and at multiple times after remission induction therapy, and their correlations were assessed.
Results: Anti-MDA5 Ab, neopterin, IL-18, ferritin, and sIL-2R levels did not differ significantly between patients who survived and those who succumbed to the disease. Read More
Ocul Immunol Inflamm 2018 Nov 16:1-9. Epub 2018 Nov 16.
b Department of Ophthalmology, Faculty of Medicine , University of Debrecen , Debrecen , Hungary.
Purpose: To evaluate corneal parameters in patients with polymyositis (PM) and dermatomyositis (DM) and compare them with those of healthy controls.
Methods: A total of 43 PM and 32 DM patients and 93 controls were enrolled in this cross-sectional, observational, case-control study. Corneal parameters were evaluated by Pentacam. Read More
Dtsch Med Wochenschr 2018 Nov 15;143(23):1690-1699. Epub 2018 Nov 15.
Many systemic diseases go along with dermal involvement. Only a few of systemic diseases show characteristic skin derangements directly leading to the diagnosis of the underlying disease. Ten of these entities are described within this article. Read More
Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.
University of Tsukuba, Department of Dermatology, Faculty of Medicine, Tsukuba, Ibaraki, Japan.
The diagnosis of clinically amyopathic dermatomyositis (CADM) essentially depends on cutaneous manifestations. The early diagnosis of CADM associated with the anti-melanoma differentiation-associated protein-5 (MDA5) antibody is especially important because it includes a subset of patients highly at risk for rapidly progressive interstitial lung disease (RP-ILD) with potentially fatal outcomes. Moreover, the recognition of distinctive rashes for anti-MDA5 antibody-positive DM can greatly aid in distinguishing from other DM subsets since serological anti-MDA5 antibody testing is not yet widely accessible. Read More
JCI Insight 2018 Nov 15;3(22). Epub 2018 Nov 15.
Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Juvenile dermatomyositis (JDM) is a debilitating pediatric autoimmune disease manifesting with characteristic rash and muscle weakness. To delineate signaling abnormalities in JDM, mass cytometry was performed with PBMCs from treatment-naive JDM patients and controls. NK cell percentages were lower while frequencies of naive B cells and naive CD4+ T cells were higher in JDM patients than in controls. Read More
JCI Insight 2018 Nov 15;3(22). Epub 2018 Nov 15.
Division of Endocrinology and Metabolism, Department of Medicine, and the Institute for Human Genetics, UCSF, San Francisco, California, USA.
Background: Inflammation helps regulate normal growth and tissue repair. Although bone morphogenetic proteins (BMPs) and inflammation are known contributors to abnormal bone formation, how these pathways interact in ossification remains unclear.
Methods: We examined this potential link in patients with fibrodysplasia ossificans progressiva (FOP), a genetic condition of progressive heterotopic ossification caused by activating mutations in the Activin A type I receptor (ACVR1/ALK2). Read More
Pediatr Rheumatol Online J 2018 Nov 13;16(1):70. Epub 2018 Nov 13.
Division of Rheumatology, Departments of Pediatrics and Medical Social Sciences, Ann & Robert H. Lurie Children's Hospital of Chicago/Northwestern University Feinberg School of Medicine, 225 E Chicago Ave Box 50, Chicago, IL, 60611, USA.
Background: Juvenile dermatomyositis (JDM) is a rare autoimmune disease that causes significant morbidity and quality of life impairment. Little is known about the inpatient burden of JDM in the US. Our goal was to determine the prevalence and risk factors for hospitalization with juvenile dermatomyositis and assess inpatient burden of JDM. Read More
Z Rheumatol 2018 Dec;77(10):952-957
Medizinische Klinik D, Sektion Rheumatologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Deutschland.
We report on a 32-year-old male patient presenting with anti-MDA-5 and anti-Ro52 antibody positive hypomyopathic dermatomyositis (CADM) with clinically leading interstitial pulmonary involvement. Under several immunosuppressive treatment regimens including high-dose steroids, cyclophosphamide, rituximab, immunoglobulins, plasmapheresis, ciclosporin and mycophenolate mofetil, pulmonary involvement was refractory to progressive. Based on the detection of a clear-cut interferon signature by flow cytometric determination of SIGLEC-1 as an interferon-dependent marker, treatment with the Janus kinase inhibitor tofacitinib was initiated. Read More
Med Sci (Paris) 2018 Nov 12;34 Hors série n°2:35-38. Epub 2018 Nov 12.
Inserm U955 Team 10, Paris Est-Créteil University, Créteil, France.
Dysimmune and inflammatory myopathies (DIMs) affect around 14/100,000 people worldwide. Based on immupour nopathological criteria, DIMs are divided in four groups: (1) polymyositis (PM)/inclusion body myositis (IBM), (2) dermatomyositis (DM), (3) immune-mediated necrotizing myopathies (IMNM) and (iv) overlapping myositis including anti-synthetase syndrome (ASS). ASS and PM/IBM are characterized by the activation of inflammation with lymphocytic infiltrations. Read More
Skinmed 2018 9;16(5):343-345. Epub 2018 Nov 9.
University of Central Florida College of Medicine, Orlando, FL.
A 39-year-old Caucasian man with a history of dermatomyositis and diabetes mellitus on a regimen of tacrolimus and methylprednisolone presented to our dermatology outpatient clinic with a painful eruption on his left lower leg. Three months before presentation, he had been admitted to the hospital for cellulitis of the left leg. During admission, a needle aspirate of the left leg cellulitis was performed to obtain fluid for culture to guide therapy. Read More
Clin Exp Dermatol 2018 Nov 8. Epub 2018 Nov 8.
St John's Institute of Dermatology, Guy's and St Thomas' NHS Trust, London, UK.
Histopathology 2018 Nov 8. Epub 2018 Nov 8.
Department of Dermatology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Aims: Persistent pruritic eruptions (PPEs), presenting with dyskeratotic keratinocytes histologically, are common in patients with adult-onset Still's disease (AOSD). The lesions may be histologically similar to other entities that present with dyskeratosis.
Methods And Results: To investigate whether histopathological findings can be used to discriminate among PPEs and other entities presenting with dyskeratotic keratinocytes, cutaneous histopathological changes of PPEs associated with AOSD (n=26) were compared with those of systemic lupus erythematosus (SLE) (n=16), dermatomyositis (n=19), and drug eruption (n=16). Read More
Gac Med Mex 2018 ;154(5):582-587
Secretaría de Salud, Hospital General de México, Servicio de Dermatología, Ciudad de México, México.
Introduction: Dermatomyositis is an autoimmune disease and the most common idiopathic inflammatory myopathy. During patient follow-up, determining biochemical parameters is required in order to assess for disease activity and treatment efficacy.
Objective: To determine the relationship between the degree of activation of the complement system through the soluble membrane attack complex (c5b-9), dermatomyositis clinical activity and its variations with conventional treatment. Read More
Soc Psychiatry Psychiatr Epidemiol 2018 Nov 7. Epub 2018 Nov 7.
Department of Psychiatry, Tzu Chi General Hospital, 707, Sec. 3, Chung Yang Rd, Hualien, 970, Taiwan.
Purpose: Studies suggested autoimmunity plays a role in the etiology of obsessive-compulsive disorder (OCD). The purpose of this study was to determine if a history of systemic autoimmune diseases (SADs) is associated with an increased risk of subsequent onset of OCD.
Methods: Patients with or without SADs were identified in the Taiwan National Health Insurance Program. Read More
RMD Open 2018 18;4(Suppl 1):e000783. Epub 2018 Oct 18.
Department of Rheumatology, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
Mixed connective tissue disease (MCTD) is a complex overlap disease with features of different autoimmune connective tissue diseases (CTDs) namely systemic sclerosis, poly/dermatomyositis and systemic lupus erythematous in patients with antibodies targeting the U1 small nuclear ribonucleoprotein particle. In this narrative review, we summarise the results of a systematic literature research which was performed as part of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases project, aimed at evaluating existing clinical practice guidelines (CPGs) or recommendations. Since no specific CPGs on MCTD were found, other CPGs developed for other CTDs were taken into consideration in order to discuss what can be applied to MCTD even if designed for other diseases. Read More
Int J Rheum Dis 2018 Nov 5. Epub 2018 Nov 5.
Department of Internal Medicine IV, Osaka Medical College, Takatsuki, Osaka, Japan.
Objectives: We assessed the efficacy and safety of combination therapy with glucocorticoids and high-trough level tacrolimus (TAC) for the treatment of acute/subacute interstitial pneumonia (A/SIP) in patients with dermatomyositis (DM).
Methods: Eleven DM-A/SIP patients were enrolled. The combination therapy with glucocorticoids and TAC was started as early as possible after DM-A/SIP was diagnosed. Read More
Int J Rheum Dis 2018 Nov 5. Epub 2018 Nov 5.
Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
Objective: Anti-transcriptional intermediary factor 1 (TIF1) antibody is associated with idiopathic inflammatory myopathies (IIMs). The aim of this study was to investigate the expression of TIF1s in IIMs.
Method: TIF1α, β or γ expression in the skin and muscle of patients and controls was studied by immunohistochemistry. Read More