11,299 results match your criteria Dermatomyositis

Significance of Sjögren's syndrome and anti-cN1A antibody in myositis patients.

Rheumatology (Oxford) 2021 May 11. Epub 2021 May 11.

Service de Physiologie, Explorations Fonctionnelles Musculaires, CHU de Strasbourg, Strasbourg, France.

Objective: We recently recorded a high prevalence of inclusion body myositis (IBM) in patients with Sjögren's syndrome (SS). Whether myositis patients with SS differ from myositis patients without SS in terms of the characteristics of the myositis is currently unknown. Anti-cytosolic 5'-nucleotidase 1 A (cN1A) has recently been proposed as a biomarker for IBM but is also frequent in SS. Read More

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Prognosis and treatment of myositis-associated severe interstitial lung disease: A descriptive study using a nation-wide inpatient database in Japan.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.

Objectives: The aim of this study was to determine the prognosis, clinical course, and current management of severe interstitial lung disease (ILD) associated with myositis in Japan.

Methods: We conducted a retrospective descriptive study using a nation-wide database for inpatient care of acute illness in Japan. Among a total of approximately 66 million inpatient admissions, we identified patients with severe ILD associated with polymyositis (PM) or dermatomyositis (DM) which required mechanical ventilation and methylprednisolone pulse therapy (≥1g/day usage of methylprednisolone) from July 2010 to March 2018. Read More

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Texture analysis of muscle MRI: machine learning-based classifications in idiopathic inflammatory myopathies.

Sci Rep 2021 May 10;11(1):9821. Epub 2021 May 10.

Department of Radiology, Saitama Medical University Hospital, 38 Morohongo Moroyama-machi, Iruma-gun, Saitama, Japan.

To develop a machine learning (ML) model that predicts disease groups or autoantibodies in patients with idiopathic inflammatory myopathies (IIMs) using muscle MRI radiomics features. Twenty-two patients with dermatomyositis (DM), 14 with amyopathic dermatomyositis (ADM), 19 with polymyositis (PM) and 19 with non-IIM were enrolled. Using 2D manual segmentation, 93 original features as well as 93 local binary pattern (LBP) features were extracted from MRI (short-tau inversion recovery [STIR] imaging) of proximal limb muscles. Read More

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Histopathological features of systemic sclerosis-associated myopathy: A scoping review.

Autoimmun Rev 2021 May 7:102851. Epub 2021 May 7.

Division of Rheumatology, Centre hospitalier de l'Université de Montréal (CHUM), CHUM Research Center, Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Background: Scleromyositis (SM) is an emerging subset of myositis associated with features of systemic sclerosis (SSc) but it is currently not recognized as a distinct histopathological subset by the European NeuroMuscular Center (ENMC). Our aim was to review studies reporting muscle biopsies from SSc patients with myositis and to identify unique histopathological features of SM.

Methods: A scoping review was conducted and included all studies reporting histopathological findings in SSc patients with myositis searching the following databases: PubMed, MEDLINE, EMBASE, CINAHL and EBM-Reviews. Read More

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Underlying diseases in sporadic presentation of high creatine kinase levels in girls.

Clin Chim Acta 2021 May 6. Epub 2021 May 6.

Department of Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan.

Background: Persistent creatine kinase (CK) elevation can occur due to various conditions. Identifying the causes of hyperCKemia is crucial for enabling appropriate follow-up and care. Girls with elevated CK levels may be carriers of Duchenne/Becker muscular dystrophy (DMD/BMD), making diagnosis more difficult than that in boys. Read More

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The seborrheic dermatitis-distributed dermatomyositis: A facial cutaneous lesions sign associated with positive anti-MDA5 antibody.

J Cosmet Dermatol 2021 May 8. Epub 2021 May 8.

Department of Allergy, Zibo Central Hospital, Zibo, 255000, China.

A 23-year-old otherwise healthy man presented with four-month history of facial itching cutaneous lesions to our allergy department. As per his own description, the lesions only involve the T zones at the onset, and it had been slowly enlarging and spreading to the forehead, glabellum and both cheek areas for four months with obvious itching. He denied the use of multiple cosmetics and used only moisturizers on a daily basis. Read More

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Calcinosis in refractory dermatomyositis improves with tofacitinib monotherapy: a case series.

Rheumatology (Oxford) 2021 May 7. Epub 2021 May 7.

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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A systematic review of the incidence, risk factors and prognosis of acute exacerbation of systemic autoimmune disease-associated interstitial lung disease.

BMC Pulm Med 2021 May 5;21(1):150. Epub 2021 May 5.

Department of Intensive Care Medicine, Northern Hospital, Melbourne, Australia.

Introduction: Acute exacerbation (AE) is a devastating phenomenon and reported to be complicated with systemic autoimmune disease-associated interstitial lung disease (ILD). The aim of this study was to investigate the incidence and prognosis of AE of systemic autoimmune disease-ILD and clarify relevant clinical information predictive of these outcomes.

Method: This study was designed as a systematic review and meta-analysis. Read More

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A Case of Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type with Dermatomyositis.

Ann Dermatol 2021 Apr 8;33(2):195-197. Epub 2021 Mar 8.

Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

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The risk of ischemic stroke in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis.

Clin Rheumatol 2021 May 1. Epub 2021 May 1.

Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao, Shandong Province, 266071, China.

Objective: Idiopathic inflammatory myopathies (IIM) are a group of chronic rheumatic diseases that can affect multiple systems; the risk of ischemic stroke in patients with IIM remains controversial. We aimed to systematically evaluate the risk of ischemic stroke in IIMs.

Methods: The PubMed, Embase, and Cochrane library were searched for relevant studies. Read More

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Juvenile idiopathic inflammatory myopathies with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in a Chinese cohort.

CNS Neurosci Ther 2021 May 1. Epub 2021 May 1.

Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Aims: To characterize the clinical and histopathological characteristics and treatment outcomes of juvenile idiopathic inflammatory myopathies (JIIMs) with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies in a Chinese cohort.

Methods: We detected anti-HMGCR antibodies in a series of Chinese JIIM by ELISA and indirect immunofluorescence assay on HEK293 cells, and summarized the clinical findings of these anti-HMGCR antibody-positive patients.

Results: Of 32 JIIM patients, 5 (15. Read More

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Access to Care and Diagnostic Delays in Juvenile Dermatomyositis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

ACR Open Rheumatol 2021 May 1. Epub 2021 May 1.

University of California, San Francisco.

Objective: To determine factors associated with diagnostic delays and outcomes in juvenile dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry (CLR).

Methods: This was a cross-sectional study of subjects aged 0 to 17 years with JDM enrolled to the CLR from 2010 to 2015. Access to care was measured by calculating the distance from the subject zip code of residence to the treating pediatric rheumatology center and determining the state density of pediatric rheumatologists based on the 2015 American College of Rheumatology Workforce Study. Read More

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Proteome study of cutaneous lupus erythematosus (CLE) and dermatomyositis skin lesions reveals IL-16 is differentially upregulated in CLE.

Arthritis Res Ther 2021 Apr 30;23(1):132. Epub 2021 Apr 30.

Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: The objective of the study was to explore the disease pathways activated in the inflammatory foci of skin lesions in cutaneous lupus erythematosus (CLE) and dermatomyositis (DM).

Methods: Skin biopsies acquired from active CLE and DM lesions, patient (PC), and also healthy controls (HC) were investigated. Biopsy sections were examined by a pathologist, inflammatory foci were laser micro-dissected and captured, and proteins within captured tissue were detected in an unbiased manner by mass spectrometry. Read More

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Clinical Features and Cutaneous Manifestations of Juvenile and Adult Patients of Dermatomyositis Associated with Myositis-Specific Autoantibodies.

Naoko Okiyama

J Clin Med 2021 Apr 16;10(8). Epub 2021 Apr 16.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.

Dermatomyositis is one of the idiopathic inflammatory myopathies, which is characterized with specific skin manifestations, and considered as an autoimmune disease. Dermatomyositis is a heterogeneous disorder with various presences, severities and characteristics of myositis, dermatitis, and interstitial lung disease. Our and others' data showed that myositis-specific autoantibodies have been associated with distinct clinical features. Read More

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Fast-Onset Diffuse Interstitial Lung Disease in Anti-MDA5 Antibodies-Associated Amyopathic Dermatomyositis.

Clin Pract 2021 Apr 22;11(2):235-240. Epub 2021 Apr 22.

Chest Diseases Department, Strasbourg University Hospital, F-67000 Strasbourg, France.

Anti-MDA5 antibodies-associated amyopathic dermatomyositisis a rare autoimmune disease that involve polyarthritis, cutaneous and pulmonary manifestations. The development of rapidly progressing interstitial lung disease is a life-threatening complication. We report the case of a 45-year-old woman without medical history, who was addressed to the Pulmonary Department for a polyarthritis with dry cough and hypoxemic dyspnea. Read More

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Epilepsy as a Comorbidity in Polymyositis and Dermatomyositis-A Cross-Sectional Study.

Int J Environ Res Public Health 2021 Apr 10;18(8). Epub 2021 Apr 10.

Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada.

Polymyositis (PM) and dermatomyositis (DM) are autoimmune-mediated multisystemic myopathies, characterized mainly by proximal muscle weakness. A connection between epilepsy and PM/DM has not been reported previously. Our study aim is to evaluate this association. Read More

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Prevalence of Nasopharyngeal Carcinoma in Patients with Dermatomyositis: A Systematic Review and Meta-Analysis.

Cancers (Basel) 2021 Apr 14;13(8). Epub 2021 Apr 14.

Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.

For more than 50 years, nasopharyngeal carcinoma (NPC) has been associated with dermatomyositis (DM), a rare idiopathic inflammatory disorder that mainly affects the skin and muscles. Although the association between these rare diseases is well-documented, the actual prevalence of NPC in DM patients remains unknown. Here, a systematic review and meta-analysis of published data was conducted in accordance with the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Read More

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Management of Myositis-Associated Interstitial Lung Disease.

Medicina (Kaunas) 2021 Apr 3;57(4). Epub 2021 Apr 3.

Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashi-ku, Hamamatsu 431-3192, Japan.

Idiopathic inflammatory myopathies, including polymyositis (PM), dermatomyositis (DM), and clinically amyopathic DM (CADM), are a diverse group of autoimmune diseases characterized by muscular involvement and extramuscular manifestations. Interstitial lung disease (ILD) has major pulmonary involvement and is associated with increased mortality in PM/DM/CADM. The management of PM-/DM-/CADM-associated ILD (PM/DM/CADM-ILD) requires careful evaluation of the disease severity and clinical subtype, including the ILD forms (acute/subacute or chronic), because of the substantial heterogeneity of their clinical courses. Read More

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Getting under the skin: ultrasound in dermatomyositis.

E Molina J Albayda

Scand J Rheumatol 2021 Apr 29:1-3. Epub 2021 Apr 29.

Department of Medicine, Division of Rheumatology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

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Gemcitabine and Docetaxel Combination Chemotherapy Induced Dermatomyositis Associated with Hand-Foot Syndrome.

Indian J Dermatol 2021 Jan-Feb;66(1):105-106

Department of Medicine of Sensory and Motor Organs, Division of Dermatology, Tottori University Faculty of Medicine, Yonago, Japan. E-mail:

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Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases.

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Department of Respiratory Medicine, Amrita Institute of Medical Science, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) displays unique cutaneous and pathologic features. We describe two cases of myositis-associated rapidly progressive interstitial lung disease (RP-ILD). The patients were two women from Kerala, India. Read More

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Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients.

Yonsei Med J 2021 May;62(5):424-430

Division of Rheumatology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.

Purpose: To investigate correlations between myositis-specific autoantibodies (MSA) or myositis-associated antibodies (MAA) and clinical features, thereby demonstrating the utility of clinicoserologic classification in idiopathic inflammatory myopathies (IIM) patients.

Materials And Methods: We conducted a multicenter study of 108 adult patients (age ≥18 years) who were diagnosed with IIM by Peter and Bohan criteria or 2004 European Neuromuscular Centre (ENMC) criteria. Clinical data were obtained by medical record review. Read More

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[Dermatomyositis as a paraneoplastic syndrome of head-neck-cancer: Case series & literature review].

Laryngorhinootologie 2021 Apr 27. Epub 2021 Apr 27.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik für Hals-Nasen-Ohrenheilkunde, Campus Benjamin Franklin.

Introduction:  Dermatomyositis (DM) is a rare disease with the clinical manifestation of weakness and pain of proximal muscles as well as lilac-coloured skin lesions. One fifth of the cases is associated with the occurrence of a malignant tumor disease. The aim of this study is to evaluate the relevance of DM as a paraneoplastic syndrome in head and neck cancer taken into account the current literature. Read More

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A Rare Case of Pembrolizumab-Induced Dermatomyositis in a Patient with Cancer of Unknown Primary Origin.

Am J Case Rep 2021 Apr 27;22:e930286. Epub 2021 Apr 27.

Department of Respiratory Medicine, Hamanomachi Hospital, Fukuoka City, Fukuoka, Japan.

BACKGROUND Pembrolizumab is a humanized monoclonal antibody against programmed cell death-1 protein. Pembrolizumab sometimes causes immune-related adverse events (irAEs). Dermatomyositis is a rare irAE of immune checkpoint inhibitors. Read More

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Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study.

Pediatr Rheumatol Online J 2021 Apr 26;19(1):56. Epub 2021 Apr 26.

Bjørknes University College, Oslo, Norway.

Background: Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children and adolescents. Both the disease and its treatment with glucocorticoids may negatively impact bone formation. In this study we compare BMD in patients (children/adolescence and adults) with long-standing JDM with matched controls; and in patients, explore how general/disease characteristics and bone turnover markers are associated with BMD. Read More

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Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.

Curr Pediatr Rev 2021 Apr 25. Epub 2021 Apr 25.

Department of Family Medicine, The University of Calgary, Calgary, Alberta, Canada.

Background: Juvenile dermatomyositis is the most common inflammatory myopathy in the pediatric age group and a major cause of mortality and morbidity in individuals with childhood rheumatic diseases. Mounting evidence suggests that early diagnosis and timely aggressive treatment are associated with better outcomes.

Objective: This purpose of this article is to provide readers with an update on the evaluation, diagnosis, and treatment of juvenile dermatomyositis. Read More

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polymorphisms and promoter hypermethylation in dermatomyositis - the role of cytosine-phosphate-guanine-related single nucleotide polymorphisms.

Immunol Invest 2021 Apr 27:1-9. Epub 2021 Apr 27.

Department of Internal Medicine, University Hospital St. Ivan Rilski, Clinic of Nephrology, Sofia, Bulgaria.

Decreased expression of the T cell receptor (TCR) ζ-chain has been reported in autoimmune diseases. Recent evidence suggests that this deficiency may be due to polymorphisms in the CD3Z (CD247) gene and/or due to promoter hypermethylation. Altogether 131 subjects - 36 with dermatomyositis (DM) and 95 healthy controls were genotyped for rs1052230 G > C and rs1052231 T > A polymorphisms using TaqMan assay. Read More

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Altered peripheral helper T cells in peripheral blood and muscle tissue of the patients with dermatomyositis.

Clin Exp Med 2021 Apr 26. Epub 2021 Apr 26.

Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, 110001, People's Republic of China.

Peripheral helper T (Tph) cells, phenotypically PD-1hiCXCR5-CD4+, are a recently identified Th cell subset that relates to several autoimmune diseases. Contrary to PD-1hiCXCR5+CD4+ follicular helper T (Tfh) cells, Tph cells are not located in lymphoid organs but accumulate in inflamed tissues. This study investigated Tph cells to determine their involvement in dermatomyositis (DM). Read More

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Management of MDA-5 antibody-positive dermatomyositis with interstitial lung disease-an Auckland case series.

Rheumatol Adv Pract 2021 7;5(1):rkab024. Epub 2021 Apr 7.

Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand.

Objective: The aim was to present our experience of managing six cases of anti-melanoma differentiation-associated gene 5 (anti-MDA-5) DM with associated interstitial lung disease (ILD), presenting between June 2017 and October 2020.

Methods: The electronic notes were reviewed for six patients being followed up by the Rheumatology service at Auckland District Health Board. Three patients were initially diagnosed and treated in neighbouring Counties Manukau District Health Board and later transferred to Auckland District Health Board. Read More

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Fatal Thrombotic Microangiopathy and Posterior Reversible Encephalopathy Syndrome in a Patient with anti-Melanoma Differentiation-associated Gene 5 Antibody-positive Dermatomyositis.

Intern Med 2021 Apr 26. Epub 2021 Apr 26.

Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Japan.

A 56-year-old woman presented with dermatomyositis positive for anti-melanoma differentiation-associated gene 5 antibody. No interstitial lung disease was detected. Despite treatment with methylprednisolone pulse therapy and cyclosporine, dysphagia developed. Read More

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