10,133 results match your criteria Dermatomyositis


Radiation-induced Köbner phenomenon in the induction of skin lesions of dermatomyositis.

Int J Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

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http://dx.doi.org/10.1111/ijd.14466DOI Listing

Extensive Persistent Panniculitis in the Context of Dermatomyositis.

J Clin Rheumatol 2019 Apr 12. Epub 2019 Apr 12.

Dermatology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/RHU.0000000000001058DOI Listing
April 2019
1 Read

MRI of skeletal muscles in patients with idiopathic inflammatory myopathies: characteristic findings and diagnostic performance in dermatomyositis.

RMD Open 2019 28;5(1):e000850. Epub 2019 Mar 28.

Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Objective: To define the characteristic findings on MRI of skeletal muscles in patients with dermatomyositis (DM) relative to those in patients with other idiopathic inflammatory myopathies (IIMs) and to assess their diagnostic performance in DM.

Methods: Thirty-six patients with DM, 17 patients with amyopathic DM, 19 patients with polymyositis and 16 patients with non-IIM classified by the 2017 European League Against Rheumatism/American College of Rheumatology criteria were included in this study. The following MRI findings (short-tau inversion recovery [STIR] and gadolinium-enhanced fat-suppressed T1-weighted imaging [Gd-T1WI]) for proximal limb muscles were compared between the disease groups and between myositis-specific autoantibodies/myositis-associated autoantibodies (MSAs/MAAs)-positive and MSAs/MAAs-negative groups: structures with high signal intensity (HSI) (subcutaneous, fascia, muscle); distributions of HSI areas in muscle (diffuse, patchy, peripheral) and patterns of HSI in muscle (honeycomb, foggy, strong HSI). Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443133PMC
March 2019
1 Read

[Advances in epigenetic markers of dermatomyositis/polymyositis].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):374-377

Department of Rheumatology and Clinical Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Idiopathic inflammatory myopathy (IIM) is a rare group of autoimmune diseases, characterized by chronic muscle weakness, muscle fatigue and infiltration of single nuclear cells in skeletal muscle. Its subtypes include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and immune-mediated necrotizing myositis (IMNM), and the most common subtypes are DM and PM. PM is an autoimmune disease mainly manifested by muscle damage. Read More

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April 2019
4 Reads

Myopathy in a 61-year-old Hispanic man.

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

A 61-year-old Hispanic man presented to a county hospital for subacute progressive weakness, heliotrope rash and dysphagia. There was initial suspicion for dermatomyositis (DM) given the history; however, the physical exam was not consistent. An MRI followed by a muscle biopsy revealed necrotising autoimmune myositis and anti-3-hydroxy-3-methylglutary-coenzyme A-reductase antibody titers returned positive; the patient was diagnosed with necrotising autoimmune myositis. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22889
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http://dx.doi.org/10.1136/bcr-2018-228892DOI Listing
April 2019
2 Reads

Response to: 'Idiopathic inflammatory myopathies and antisynthetase syndrome: contribution of antisynthetase antibodies to improve current classification criteria' by Greco .

Ann Rheum Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Internal Medicine 3, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2019-215484DOI Listing
April 2019
1 Read

Dermatomyositis and MIG.

Authors:
F Ragusa

Clin Ter 2019 Mar-Apr;170(2):e142-e147

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Several studies demonstrated the presence of an elevated expression of chemokine (C-X-C motif) ligand (CXCL)9/monokine induced by interferon (IFN)-γ (MIG) on macrophages and in T cells in perimysial infiltrates of patients with dermatomyositis (DM), and of chemokine (C-X-C motif) receptor (CXCR)3 expression on the majority of T cells in the same patients. This underlines the importance of T helper 1-mediated immunity, and in particular the MIG/CXCR3 interaction, in the immunopathogenesis of DM. The importance of MIG has been confirmed by a study on patients with DM about the presence of chemokines and their receptors in infiltrating cells at the level of lesional skin. Read More

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http://dx.doi.org/10.7417/CT.2019.2124DOI Listing
April 2019
1 Read

Frequency, mutual exclusivity and clinical associations of myositis autoantibodies in a combined European cohort of idiopathic inflammatory myopathy patients.

J Autoimmun 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. Electronic address:

Objectives: To determine prevalence and co-existence of myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs) and associated clinical characteristics in a large cohort of idiopathic inflammatory myopathy (IIM) patients.

Methods: Adult patients with confirmed IIM recruited to the EuroMyositis registry (n = 1637) from four centres were investigated for the presence of MSAs/MAAs by radiolabelled-immunoprecipitation, with confirmation of anti-MDA5 and anti-NXP2 by ELISA. Clinical associations for each autoantibody were calculated for 1483 patients with a single or no known autoantibody by global linear regression modelling. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.04.001DOI Listing
April 2019
1 Read

[Cognitive dysfunction, loss of visual acuity and hearing can be symptoms of Susac syndrome].

Ugeskr Laeger 2019 Apr;181(15)

This is a case report of a 56-year-old male patient with Susac syndrome. The syndrome is a rare immune-mediated, ischaemic, occlusive microvascular endotheliopathy affecting the brain, retina and inner ear. Diagnosis and treatment are challenging, since the presentation shows great variability. Read More

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April 2019
2 Reads

[Dermatomyositis].

Authors:
Manabu Fujimoto

Brain Nerve 2019 Apr;71(4):323-328

Dermatology, Department of Integrated Medicine, Graduate School of Medicine, Osaka University.

When examining the skin manifestations of dermatomyositis, it is important to systematically observe the frequently affected sites. The head and the hands are particularly important. It is critical to look not just for symptoms included in the classification criteria, such as heliotrope rash and Gottron's papules/signs, but also for other rashes. Read More

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http://dx.doi.org/10.11477/mf.1416201269DOI Listing
April 2019
1 Read

Upper Esophageal Sphincter Dilation for Recalcitrant Dysphagia Secondary to Dermatomyositis.

Ear Nose Throat J 2019 Apr 15:145561319842511. Epub 2019 Apr 15.

1 Department of Otolaryngology, Head and Neck Surgery, Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1177/0145561319842511DOI Listing
April 2019
1 Read

Dermatomyositis associated with adenocarcinoma of the lung: A case report.

J Family Med Prim Care 2019 Feb;8(2):754-756

Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.

The association of dermatomyositis and underlying malignancies, especially small cell and squamous cell carcinoma of the lung, has been recognized a long time ago. We report the case of a 63-year-old male chronic smoker with adenocarcinoma lung associated with dermatomyositis. The occurrence of dermatomyositis should be considered as a potential presentation of paraneoplastic syndromes and physicians encountering similar clinical situations should perform extensive diagnostic work-up to exclude underlying neoplastic lesions. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_467_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436299PMC
February 2019
1 Read

Polymyositis-Dermatomyositis and Interstitial Lung Disease in Pregnant Woman Successfully Treated with Cyclosporine and Tapered Steroid Therapy.

Case Rep Rheumatol 2019 11;2019:4914631. Epub 2019 Mar 11.

Department of Rheumatology, Showa University School of Medicine, Tokyo, Japan.

Polymyositis-dermatomyositis is extremely rare during pregnancy, and immunosuppressive therapy should be administered after carefully considering the effects on both the mother and fetus. Several reports have associated the disease activity with fetal prognosis, higher rates of eclampsia, preterm births, and fetal deaths. We report our experience with a patient who was diagnosed with polymyositis-dermatomyositis complicated by interstitial lung disease during pregnancy and was treated with a combination-immunosuppressant regimen. Read More

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http://dx.doi.org/10.1155/2019/4914631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432726PMC
March 2019
1 Read

A novel case of TIF1 gamma autoantibody positive dermatomyositis associated with a non-functional pancreatic neuroendocrine tumor.

Dermatol Online J 2019 03 15;25(3). Epub 2019 Mar 15.

Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.

Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by proximal muscle weakness associated with a distinct cutaneous eruption. The association of DM with malignancy has been extensively described in the literature. Patients with DM that also have transcriptional intermediary factor 1γ (TIF1γ) autoantibodies (anti-p155, anti-p155/140) have higher rates of malignancy when compared to those without the autoantibody. Read More

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March 2019
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Anti-FIRΔexon2, a splicing variant form of PUF60, auto-antibody is detected in the sera of esophageal squamous cell carcinoma.

Cancer Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Anti-PUF60 autoantibodies are reportedly detected in the sera of patients with dermatomyositis and Sjogren's syndrome; however, little is known regarding its existence in the sera of cancer patients. FIR, a splicing variant of the PUF60 gene, is a transcriptional repressor of c-myc. In colorectal cancer, there is an overexpression of the dominant negative form of FIR, in which exon 2 is lacking (FIRΔexon2). Read More

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http://dx.doi.org/10.1111/cas.14024DOI Listing
April 2019
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Overlap myositis, a distinct entity beyond primary inflammatory myositis: A retrospective analysis of a large cohort from the REMICAM registry.

Int J Rheum Dis 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Inflammatory idiopathic myositis (IIM) comprises a heterogeneous group of systemic muscular diseases that can occur together with other connective tissue diseases (CTD), named overlap myositis (OM). The question of whether OM is a distinct entity still remains controversial.

Aim: The present study was conducted to assess the clinical and prognostic differences between patients diagnosed with OM, primary polymyositis (PM) and primary dermatomyositis (DM). Read More

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http://dx.doi.org/10.1111/1756-185X.13559DOI Listing
April 2019
1 Read

Pruritus in patients with amyopathic dermatomyositis.

Allergy Asthma Clin Immunol 2019 27;15:18. Epub 2019 Mar 27.

1Department of Medicine, Nazarbayev University School of Medicine, Kerei-Zhanibek Str. 5/1, Astana, 010000 Kazakhstan.

Amyopathic dermatomyositis has been associated with the exposure to several drugs: the article by Jeimy et al. described the onset of this uncommon disease in a patient treated with omalizumab. Paradoxically, this patient complained of an intense pruritus and this finding has been reported by several authors observing patients with amyopathic dermatomyositis. Read More

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http://dx.doi.org/10.1186/s13223-019-0334-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437865PMC
March 2019
1 Read

The Role of Exosome in Autoimmune Connective Tissue Disease.

Ann Med 2019 Apr 9:1-15. Epub 2019 Apr 9.

a Departments of Dermatology , Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing , China , 100730.

Exosomes have generated significant interest in the last few decades owing to their important roles in a diverse range of biological pathways. They are nano-sized lipid bilayer membrane vesicles of endosomal origin, and are produced by a vast number of cell types. They are released into the extracellular environment and are found in most biological fluids. Read More

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http://dx.doi.org/10.1080/07853890.2019.1592215DOI Listing
April 2019
1 Read
3.886 Impact Factor

Absence of sarcoplasmic MxA expression in antisynthetase syndrome in cohort of 194 cases.

Neuropathol Appl Neurobiol 2019 Apr 8. Epub 2019 Apr 8.

Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

We have read with great interest the recent article entitled 'Diagnostic potential of sarcoplasmic MxA expression in subsets of dermatomyositis' by Uruha et al. [1]. The authors validated the diagnostic utility of myxovirus resistance protein A (MxA) expression in myofibers in dermatomyositis (DM) as compared with other diagnostic markers regardless of subsets, following the first report for MxA as a diagnostic marker of DM [2]. Read More

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http://dx.doi.org/10.1111/nan.12551DOI Listing
April 2019
1 Read
3.927 Impact Factor

Association of dermatomyositis with systemic and opportunistic infections in the United States.

Arch Dermatol Res 2019 Apr 6. Epub 2019 Apr 6.

Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.

Patients with dermatomyositis have multiple risk factors for serious and opportunistic infections, including immune dysregulation, long-term systemic corticosteroid treatment and comorbid health conditions. We sought to determine whether dermatomyositis is associated with increased odds and burden of systemic, opportunistic and antibiotic-resistant infections. We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, containing a cross-sectional representative 20% sample of all hospitalizations in the US. Read More

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http://link.springer.com/10.1007/s00403-019-01913-0
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http://dx.doi.org/10.1007/s00403-019-01913-0DOI Listing
April 2019
5 Reads

Novel susceptibility alleles in HLA region for myositis and myositis specific autoantibodies in Korean patients.

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, 28 Yongun-dong, Chongno-gu, Seoul 110-744, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, College of Medicine, Seoul National University, Seoul, South Korea. Electronic address:

Objectives: HLA genes are a major genetic risk factor for myositis and myositis specific antibodies (MSAs), exhibiting unique HLA backgrounds for myositis in different ethnic groups. This is the first large scale Korean study to genotype the HLA-DRB1 and -DPB1 alleles and to examine their association with myositis and MSAs.

Methods: HLA-DRB1 and HLA-DPB1 alleles and MSAs were examined in 179 patients with dermatomyositis (DM, n = 129) or polymyositis (PM, n = 50) and healthy controls (n = 800 for HLA-DRB1, n = 548 for HLA-DPB1). Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.03.005DOI Listing
March 2019
4 Reads

Lymphatic Function in Autoimmune Diseases.

Front Immunol 2019 20;10:519. Epub 2019 Mar 20.

HSS Research Institute, Hospital for Special Surgery, New York, NY, United States.

Lymphatic vessels are critical for clearing fluid and inflammatory cells from inflamed tissues and also have roles in immune tolerance. Given the functional association of the lymphatics with the immune system, lymphatic dysfunction may contribute to the pathophysiology of rheumatic autoimmune diseases. Here we review the current understanding of the role of lymphatics in the autoimmune diseases rheumatoid arthritis, scleroderma, lupus, and dermatomyositis and consider the possibility that manual therapies such as massage and acupuncture may be useful in improving lymphatic function in autoimmune diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435962PMC
March 2019
2 Reads

Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases.

Clin Exp Rheumatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Paediatrics, Division of Rheumatology, The University of British Columbia, and BC Children's Hospital Research Institute, Vancouver, Canada.

Type I interferons (IFN) are a class of inducible and protective cytokines best known for immune defence against viruses and intracellular bacteria. Inappropriate stimulation or defective negative regulation of type I IFN expression however can lead to persistent type I IFN activity with detrimental effects. This is particularly relevant for a class of monogenic autoinflammatory diseases ("type I interferonopathies"), along with many other complex rheumatic diseases such as systemic lupus erythematosus (SLE), dermatomyositis (DM), systemic sclerosis (SSc), rheumatoid arthritis (RA) and Sjögren's syndrome (SS). Read More

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March 2019
7 Reads

Clinical significance of myositis-specific autoantibodies.

Authors:
Ran Nakashima

Immunol Med 2018 Sep 17;41(3):103-112. Epub 2018 Nov 17.

a Department of Rheumatology and Clinical Immunology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.

To date, increasing numbers of myositis-specific autoantibodies (MSAs) have been reported and their clinical significance has been elucidated. Anti-aminoacyl-tRNA synthetase (ARS) and anti-melanoma-differentiation associated gene 5 (MDA5) are strongly associated with interstitial lung disease (ILD); however, the clinical course of ILD is different depending on which autoantibody is present. Anti-ARS is associated with chronic and repetitive ILD and anti-MDA5 is associated with rapidly progressive ILD. Read More

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http://dx.doi.org/10.1080/25785826.2018.1531188DOI Listing
September 2018
3 Reads

Myositis an evolving spectrum of disease.

Immunol Med 2018 Jun 11;41(2):46-54. Epub 2018 Sep 11.

b Division of rheumatology, Department of Medicine , Solna, Karolinska Institutet, and Karolinska University Hospital , Stockholm , Sweden.

The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of disorders characterized, as common feature, by inflammation of skeletal muscle and muscle weakness. Traditionally, IIMs have been subclassified in into polymyositis, dermatomyositis and inclusion body myositis, but this subclassification has several limitations, because clinical features as well as treatment response vary within the three IIM subgroups. In the last years several novel autoantibodies in patients with IIMs have been identified. Read More

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http://dx.doi.org/10.1080/13497413.2018.1481571DOI Listing
June 2018
6 Reads

Curling Cuticles of the Great Toenails: A Case Report of Eponychogryphosis.

Authors:
Philip R Cohen

Cureus 2019 Jan 25;11(1):e3959. Epub 2019 Jan 25.

Dermatology, San Diego Family Dermatology, San Diego, USA.

The cuticle, also referred to as the eponychium, creates a seal between the proximal nail fold and the nail plate. It is derived from both the ventral and dorsal portions of the proximal nail fold. In addition to its principle function as a barrier preventing allergens, irritants and pathogens from entering the nail cul-de-sac, the cuticle can play a role as a model for evaluating the etiology and management of diseases that affect capillary microcirculation, provide a source of solid tissue for genetic disorder studies, and aid in the evaluation of patients in whom the diagnoses of either systemic scleroderma or dermatomyositis is being entertained. Read More

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http://dx.doi.org/10.7759/cureus.3959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433083PMC
January 2019
4 Reads

Juvenile Dermatomyositis: A Case Report and Review of Literature.

Cureus 2019 Jan 22;11(1):e3935. Epub 2019 Jan 22.

Pathology, National Institute of Pathology, New Delhi, IND.

Juvenile dermatomyositis (JDM) is a systemic inflammatory disease involving children, which primarily affects the skin and the musculoskeletal system. The characteristic findings include Gottron papules, heliotrope rash, calcinosis cutis, and symmetric proximal muscle weakness. Histologically, it is characterized by the presence of lymphocytic vascular inflammation and endothelial swelling. Read More

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http://dx.doi.org/10.7759/cureus.3935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433086PMC
January 2019
1 Read

Dermatomyositis antibodies continue to mysTIFy.

Authors:
D Fiorentino

Br J Dermatol 2019 Apr;180(4):709-710

Department of Dermatology, Stanford University School of Medicine, 450 Broadway, Redwood City, CA, U.S.A.

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http://dx.doi.org/10.1111/bjd.17497DOI Listing
April 2019
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Successful treatment of a locally advanced unresectable pancreatic cancer patient with interstitial pneumonitis by conversion surgery following gemcitabine plus nab-paclitaxel chemotherapy: A case report.

Mol Clin Oncol 2019 Apr 4;10(4):419-424. Epub 2019 Feb 4.

Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8677, Japan.

Conversion surgery is an attractive strategy to improve the outcomes for locally advanced unresectable (UR-LA) pancreatic ductal adenocarcinoma (PDAC). The present case report, presents a case of successful conversion surgery following the treatment of a patient with UR-LA PDAC, suffering from interstitial pneumonitis (IP), using a combination of gemcitabine and nab-paclitaxel (GnP). A 67-year-old woman presented at the hospital with a high level of carbohydrate antigen 19-9 (CA19-9; 1,713 U/ml). Read More

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http://dx.doi.org/10.3892/mco.2019.1807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425509PMC
April 2019
1 Read

[Dermatomyositis-like syndrome revealing statin-induced necrotizing autoimmune myopathy with anti-HMGCR antibodies].

Ann Dermatol Venereol 2019 Mar 28. Epub 2019 Mar 28.

Service de dermatologie, hôpital Bichat, Assistance publique des Hôpitaux de Paris (AP-HP), 46, rue Henri-Huchard, 75018 Paris, France.

Background: Statin-induced necrotizing autoimmune myopathy (NAM) has been recently characterized. Herein we report an accurate description of the clinical and histological characteristics of cutaneous rash associated with NAM.

Patients And Methods: A 61-year-old woman presented a skin rash involving the face, the chest and the back of the hands with heliotropic distribution coupled with proximal symmetrical muscle weakness. Read More

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http://dx.doi.org/10.1016/j.annder.2018.12.010DOI Listing
March 2019
4 Reads

Prognostic factors of interstitial lung disease progression at sequential HRCT in anti-synthetase syndrome.

Eur Radiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Pulmonology, China-Japan Friendship Hospital, Beijing, 100029, China.

Objectives: Interstitial lung disease (ILD) is a common extra-muscular manifestation of anti-synthetase syndrome (ASS) and the main cause of morbidity and mortality in patients with ASS. Data on prognostic factors in these patients are lacking.

Methods: A total of 69 patients with ILD and positivity for at least one of the following autoantibodies were included: anti-Jo-1, anti-PL7, anti-PL12, and anti-EJ. Read More

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http://dx.doi.org/10.1007/s00330-019-06152-5DOI Listing
March 2019
1 Read

Specific Autoantibodies and Clinical Phenotypes Correlate with the Aberrant Expression of Immune-Related MicroRNAs in Dermatomyositis.

J Immunol Res 2019 19;2019:2927061. Epub 2019 Feb 19.

Department of Rheumatology, Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Yinghua East Road, Chaoyang District, Beijing 100029, China.

Aims: The serum concentrations of miRNAs, miR-23a-3p, miR-23b-3p, miR-146a-5p, miR-146b-5p, and miR-150-5p, were shown to be associated with the immune and inflammatory progressions. We assessed the expressions of these five miRNAs in association with clinical phenotypes and myositis-specific autoantibody-defined subgroups of dermatomyositis (DM).

Methods: The present study included 49 patients with DM and 30 healthy controls. Read More

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http://dx.doi.org/10.1155/2019/2927061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399529PMC
February 2019
1 Read

Dermatomyositis.

CMAJ 2019 Mar;191(12):E340

Postgraduate Medical Education (Chu), Schulich School of Medicine & Dentistry, Western University; Department of Rheumatology (Rohekar), St. Joseph's Health Care London, London, Ont.

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http://dx.doi.org/10.1503/cmaj.180947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435364PMC
March 2019
1 Read

Relative risk of microscopic colitis in dermatomyositis.

J Am Acad Dermatol 2019 Mar 22. Epub 2019 Mar 22.

Corporal Michael J. Crescenz VAMC, Philadelphia, PA; Department of Dermatology, University of Pennsylvania Perelman School of Medicine.

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http://dx.doi.org/10.1016/j.jaad.2019.03.045DOI Listing
March 2019
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Global analysis of protein expression in muscle tissues of dermatomyositis/polymyosisits patients demonstrated an association between dysferlin and human leucocyte antigen A.

Rheumatology (Oxford) 2019 Mar 25. Epub 2019 Mar 25.

Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, China.

Objectives: DM and PM are characterized by myofibre damage with inflammatory cell infiltration due to the strong expressions of MHC class I HLA-A and monocyte chemoattractant protein-1 (MCP-1). Dysferlin (DYSF) is a transmembrane glycoprotein that anchors in the sarcolemma of myofibres. DYSF mutation is closely associated with inherited myopathies. Read More

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http://dx.doi.org/10.1093/rheumatology/kez085DOI Listing
March 2019
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Small cell lung cancer and interstitial pneumonia associated with anti-transcriptional intermediary factor-1γ-positive dermatomyositis.

Respirol Case Rep 2019 May 12;7(4):e00412. Epub 2019 Mar 12.

Department of Respiratory Medicine and Allergology Aichi Medical University Nagakute Japan.

Antibodies to transcriptional intermediary factor-1γ (TIF-1γ) are strongly associated with malignancy in patients with dermatomyositis but a relatively low risk for interstitial lung disease. We report the case of a 68-year-old female with small cell lung cancer (SCLC) and interstitial pneumonia who was diagnosed first with dermatomyositis positive for serum anti-TIF-1γ antibodies. Because interstitial pneumonia co-existed, she was treated with carboplatin and etoposide without radiotherapy. Read More

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http://dx.doi.org/10.1002/rcr2.412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412960PMC
May 2019
1 Read

Comparison of the 2017 EULAR/ACR criteria with Bohan and Peter criteria for the classification of idiopathic inflammatory myopathies.

Clin Rheumatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Clinical Immunology and Rheumatology, St John's Medical College, Sarjapur Road, Bengaluru, 560034, India.

Bohan and Peter is the oldest criteria for the classification of idiopathic inflammatory myopathies (IIM). Recently, 2017 EULAR/ACR criteria were introduced which were validated against a control group. The objective of this study was to assess the performance of the 2017 EULAR/ACR criteria in retrospective cohort of adult and juvenile idiopathic inflammatory myopathies and compare with Bohan and Peter criteria. Read More

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http://dx.doi.org/10.1007/s10067-019-04512-6DOI Listing
March 2019
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Increased risk of coronary heart disease among patients with idiopathic inflammatory myositis: a nationwide population study in Taiwan.

Rheumatology (Oxford) 2019 Mar 21. Epub 2019 Mar 21.

School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objective: To evaluate the risk of incident coronary heart disease (CHD) among patients with DM and PM in a general population context.

Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database containing records covering the years from 2000 to 2010. DM and PM were confined for the purposes of this study to those aged ⩾18 years who were eligible for the Taiwan catastrophic illness certificate. Read More

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http://dx.doi.org/10.1093/rheumatology/kez076DOI Listing
March 2019
5 Reads

The IgG2 isotype of anti-transcription intermediary factor 1-gamma autoantibodies is a biomarker of mortality in adult dermatomyositis.

Arthritis Rheumatol 2019 Mar 21. Epub 2019 Mar 21.

Normandie University, UNIROUEN, IRIB, Inserm, U1234, Rouen University Hospital, Department of Immunology and Biotherapy, Rouen, France.

Objective: Anti-TIF1γ antibodies (aAb) are the main predictors of cancer in dermatomyositis (DM). Yet, a substantial proportion of anti-TIF1γ DM patients remain without cancer. Our objective was to identify biomarkers to better evaluate the risk of cancer and mortality. Read More

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http://dx.doi.org/10.1002/art.40895DOI Listing
March 2019
2 Reads

Serum KL-6 is associated with the severity of interstitial lung disease in Chinese patients with polymyositis and dermatomyositis.

Clin Rheumatol 2019 Mar 19. Epub 2019 Mar 19.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College &Chinese Academy of Medical Sciences, No.1 Shuaifuyuan, Beijing, 100730, China.

Objective: This cross-sectional study was designed to assess the clinical significance of the serum KL-6 in the diagnosis of interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathy (IIM).

Methods: We measured serum KL-6 levels in 184 patients with IIM using a chemiluminescent enzyme immunoassay and compared KL-6 levels between patients with and without ILD, according to other clinical features.

Results: IIM patients with ILD had significantly higher serum KL-6 levels than those without ILD (776. Read More

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http://dx.doi.org/10.1007/s10067-019-04501-9DOI Listing
March 2019
3 Reads
1.774 Impact Factor

The use of naltrexone in dermatology. Current evidence and future directions.

Curr Drug Targets 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Medical University of Warsaw, Warsaw. Poland.

Naltrexone is a competitive opioid receptor antagonist approved as supportive treatment in alcohol dependence and opioid addiction. In a dose 50-100 mg daily, naltrexone is used off-label in dermatology for the treatment of trichotillomania and different types of pruritus. At a dose as low as 1-5 mg of drug per day, naltrexone demonstrates immunomodulatory action i. Read More

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http://dx.doi.org/10.2174/1389450120666190318121122DOI Listing
March 2019
12 Reads

Distinct interferon signatures stratify inflammatory and dysimmune myopathies.

RMD Open 2019 26;5(1):e000811. Epub 2019 Feb 26.

IMRB, Inserm U955-Team 10, Paris Est-Creteil University, Paris, France.

Objective: The role of interferons (IFN) in the pathophysiology of primary inflammatory and dysimmune myopathies (IDM) is increasingly investigated, notably because specific neutralisation approaches may constitute promising therapeutic tracks. In present work we analysed the muscular expression of specific IFNα/β and IFNγ-stimulated genes in patients with various types of IDM.

Methods: 39 patients with IDM with inclusion body myositis (IBM, n=9), dermatomyositis (DM, n=10), necrotising autoimmune myopathies (NAM, n=10) and antisynthetase myositis (ASM, n=10), and 10 controls were included. Read More

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2018-00081
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http://dx.doi.org/10.1136/rmdopen-2018-000811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397431PMC
February 2019
6 Reads

Imaging findings of mixed connective tissue disease in children and adolescents: a case series.

Jpn J Radiol 2019 Mar 14. Epub 2019 Mar 14.

Department of Rheumatology, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.

Mixed connective tissue disease (MCTD) is a rare disease in children and adolescents which overlaps features of juvenile idiopathic arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. We have provided an image-based approach for evaluation of MCTD in children and adolescents, outlying the most frequent imaging findings. This approach would aid imagers and clinicians to consider the diagnosis of this rare entity and be able to make an accurate list of differential diagnosis for complex rheumatologic diseases such as MCTD, thus facilitating the ultimate goal of early diagnosis and optimal management of affected children. Read More

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http://dx.doi.org/10.1007/s11604-019-00824-4DOI Listing
March 2019
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Gastric cancer and paraneoplastic dermatomyositis as complications of an unrecognized juvenile polyposis syndrome.

Z Gastroenterol 2019 Apr 14;57(4):497-500. Epub 2019 Mar 14.

Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Juvenile polyposis syndrome is a rare autosomal-dominant disorder characterized by multiple hamartomatous polyps in the gastrointestinal tract. It is associated with an increased risk of gastrointestinal cancer. We report the case of a 49-year-old woman presenting with proximal muscle weakness, weight loss, severe anemia, and melena. Read More

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http://dx.doi.org/10.1055/a-0855-4404DOI Listing
April 2019
3 Reads

The spectrum and clinical significance of myositis-specific autoantibodies in Chinese patients with idiopathic inflammatory myopathies.

Clin Rheumatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Rheumatology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang District, Beijing, China.

Objectives: The aim of this study is to analyze the prevalence of myositis-specific autoantibodies (MSAs) and to elucidate their associations with clinical features in Chinese patients with polymyositis (PM) and dermatomyositis (DM).

Methods: Twelve subsets of MSAs including anti-Mi-2, anti-TIF1-γ, anti-MDA5, anti-NXP2, anti-SAE1, anti-SRP, anti-Jo-1, anti-PL-7, anti-PL-12, anti-EJ, anti-OJ, and anti-HMGCR antibodies were tested. Four hundred and ninety-seven PM/DM patients were enrolled. Read More

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http://dx.doi.org/10.1007/s10067-019-04503-7DOI Listing
March 2019
3 Reads

Successful treatment of extensive calcifications and acute pulmonary involvement in dermatomyositis with the Janus-Kinase inhibitor tofacitinib - A report of two cases.

J Autoimmun 2019 Mar 9. Epub 2019 Mar 9.

Department of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, Hugstetter Str. 55, 79106, Freiburg, Germany. Electronic address:

Introduction: Dermatomyositis (DM) can be complicated by calcinosis and interstitial lung disease (ILD). Calcinosis can be severely debilitating or life-threatening and to date there is no treatment with proven efficacy. In DM type I interferon contributes to pathophysiology by inducing the expression of proinflammatory cytokines and the JAK-STAT (signal transducer and activator of transcription) pathway may be involved in the regulation of mitochondrial calcium store release, a process potentially important for calcification in DM. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.03.003DOI Listing
March 2019
1 Read

Galectin-9 and CXCL10 as biomarkers for disease activity in juvenile dermatomyositis: a longitudinal cohort study and multi-cohort validation.

Arthritis Rheumatol 2019 Mar 12. Epub 2019 Mar 12.

Laboratory of translational immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.

Objective: Objective evaluation of disease activity is challenging in patients with juvenile dermatomyositis (JDM) due to lack of biomarkers, but crucial to avoid both under- and overtreatment. Recently, we identified two proteins that highly correlate with JDM disease activity: galectin-9 and CXCL10. Here, we validate galectin-9 and CXCL10 as biomarkers for disease activity, assess disease-specificity and investigate their potency to predict flares. Read More

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http://dx.doi.org/10.1002/art.40881DOI Listing
March 2019
2 Reads