10,700 results match your criteria Dermatomyositis


Toripalimab-Induced Dermatomyositis in a Patient with Metastatic Melanoma.

Dermatol Ther (Heidelb) 2020 May 22. Epub 2020 May 22.

Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China.

Toripalimab is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). It has recently been approved as an immune checkpoint inhibitor in second-line therapies in patients with unresectable or metastatic melanoma; however, it may be associated with various immune-related adverse events (irAEs). Here we report a case of toripalimab-induced dermatomyositis in a patient receiving treatment for metastatic melanoma. Read More

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http://dx.doi.org/10.1007/s13555-020-00396-6DOI Listing

Epigenetic Methods and Twin Studies.

Adv Exp Med Biol 2020 ;1253:95-104

Humanitas Clinical and Research Center-IRCCS, via Manzoni 56, 20089, Rozzano, Milan, Italy.

Genomic predisposition fails to fully explain the onset of complex diseases, which is well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodeling, and non-coding RNA, are the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseases. Autoimmune diseases now include almost 100 conditions and are estimated to cumulatively affect up to 5% of the world population with a healthcare expenditure superior to cancer worldwide. Read More

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http://dx.doi.org/10.1007/978-981-15-3449-2_3DOI Listing
January 2020

Antibodies against immunogenic epitopes with high sequence identity to SARS-CoV-2 in patients with autoimmune dermatomyositis.

Ann Rheum Dis 2020 May 22. Epub 2020 May 22.

Division of Population Health, Health Services Research and Primary Care, The University of Manchester, Manchester, Manchester, UK

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http://dx.doi.org/10.1136/annrheumdis-2020-217522DOI Listing

The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis.

J Am Acad Dermatol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8512, Japan.

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http://dx.doi.org/10.1016/j.jaad.2020.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234944PMC

Response to: Dermatologic manifestations of hydroxychloroquine therapy: a closer look at the nails.

J Am Acad Dermatol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, University of California, San Diego. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.05.063DOI Listing
May 2020
4.449 Impact Factor

MR imaging findings of calcinosis cutis in primary Sjogren syndrome, a rare manifestation.

Radiol Case Rep 2020 Jul 15;15(7):1029-1038. Epub 2020 May 15.

Department of Surgery, UF Health Jacksonville, Jacksonville, FL 32209, USA.

Soft tissue calcifications associated with various connective tissue diseases such as dermatomyositis and scleroderma have been well documented Plaque-like sheets of subcutaneous calcifications presenting as an indurated soft tissue mass in a patient with primary Sjogren syndrome have been rarely documented in the literature. We present the magnetic resonance and conventional radiographic findings of calcinosis cutis and calcinosis circumscripta of a 47-year-old woman with biopsy proven Sjogren syndrome. We also delineate various types of soft tissue calcification, histopathology of calcinosis cutis, and current treatment options. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229417PMC

Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E Production.

Front Pharmacol 2020 6;11:613. Epub 2020 May 6.

Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.

We screened 57 chemical probes, high-quality tool compounds, and relevant clinically used drugs to investigate their effect on pro-inflammatory prostaglandin E (PGE) production and interleukin-8 (IL-8) secretion in human whole blood. Freshly drawn blood from healthy volunteers and patients with systemic lupus erythematosus (SLE) or dermatomyositis was incubated with compounds at 0.1 or 1 µM and treated with lipopolysaccharide (LPS, 10 µg/ml) to induce a pro-inflammatory condition. Read More

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http://dx.doi.org/10.3389/fphar.2020.00613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218097PMC

Mortality risk prediction in amyopathic dermatomyositis associated with interstitial lung disease: the FLAIR model.

Chest 2020 May 16. Epub 2020 May 16.

Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China. Electronic address:

Background: The prognosis of amyopathic dermatomyositis (ADM)-associated interstitial lung disease (ILD) is poor. A mortality risk score model is needed to predict survival in patients with ADM-ILD and guide clinical treatment.

Research Question: How to identify ADM-ILD patients at high risk and to predict patients' outcome based on a risk stratification model?

Study Design: and Methods: We evaluated 207 patients with ADM-ILD in this prospective inception study. Read More

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http://dx.doi.org/10.1016/j.chest.2020.04.057DOI Listing

Juvenile dermatomyositis presenting as complete heart block in a 10-year-old girl.

Paediatr Int Child Health 2020 May 19:1-4. Epub 2020 May 19.

Department of Neuromedicine, Bangur Institute of Neurosciences, Institute of Postgraduate Medical Education and Research & SSKM Hospital, Kolkata, India.

Juvenile dermatomyositis (JDM) is an auto-immune inflammatory condition associated with cardiac disorders including conduction abnormalities and myocardial dysfunction. The time of presentation of cardiac abnormalities can range from disease onset to after long-term follow-up, emphasising the importance of screening for cardiac involvement in JDM. A previously healthy 10-year-old girl presented with syncope, fatigue and weakness associated with a heliotrope rash. Read More

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http://dx.doi.org/10.1080/20469047.2020.1765123DOI Listing

Paraneoplastic dermatomyositis in hereditary breast and ovarian cancer syndrome.

Authors:
Navin Kumar Svs Deo

Breast J 2020 May 18. Epub 2020 May 18.

Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1111/tbj.13888DOI Listing

Case of zinc deficiency-induced dermatomyositis-like dermatitis: Association between absence of CD1a-positive Langerhans cells and development of dermatitis.

J Dermatol 2020 May 15. Epub 2020 May 15.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

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http://dx.doi.org/10.1111/1346-8138.15394DOI Listing

Successful treatment of steroid-refractory immune checkpoint inhibitor-related pneumonitis with triple combination therapy: a case report.

Cancer Immunol Immunother 2020 May 15. Epub 2020 May 15.

Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, 3-19-18 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Immune checkpoint inhibitor (ICI)-related pneumonitis is a relatively rare but clinically serious and potentially life-threatening adverse event. The majority of cases can be managed by drug discontinuation, with the administration of corticosteroids added in severe cases. However, worsening of pneumonitis can develop in a subset of patients despite treatment with high doses of corticosteroids. Read More

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http://dx.doi.org/10.1007/s00262-020-02600-0DOI Listing

Lessons of the month: Herpetic viral dermatomyositis.

Clin Med (Lond) 2020 May;20(3):e12-e14

Aster Medcity, Kochi, India.

We present the case of a man who presented with severe left lower back pain radiating to the anterior aspect of left thigh. He also had fever and headache. Due to the exquisite tenderness along the inguinal region, the possibility of a psoas abscess was considered. Read More

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http://dx.doi.org/10.7861/clinmed.2020-0078DOI Listing

Mitochondrial Dysfunction: A Common Hallmark Underlying Comorbidity between sIBM and Other Degenerative and Age-Related Diseases.

J Clin Med 2020 May 13;9(5). Epub 2020 May 13.

Muscle Research and Mitochondrial Function Laboratory, CELLEX-IDIBAPS, Faculty of Medicine, University of Barcelona, 08036 Barcelona, Spain.

Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy associated, among others, with mitochondrial dysfunction. Similar molecular features are found in Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM), underlying potential comorbidity. This study aims to evaluate common clinical and molecular hallmarks among sIBM, AD, and T2DM. Read More

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http://dx.doi.org/10.3390/jcm9051446DOI Listing

Anti-MDA5 Positive Dermatomyositis Associated with Rapidly Progressive Interstitial Lung Disease and Correlation between Serum Ferritin Level and Treatment Response.

Mediterr J Rheumatol 2020 Mar 31;31(1):75-77. Epub 2020 Mar 31.

Department of Internal Medicine A, The Chaim Sheba Medical Center, Ramat Gan, Israel.

Clinically amyopathic dermatomyositis is an uncommon autoimmune disorder in the Middle East. The clinical picture of clinically amyopathic dermatomyositis is characterized mainly by pulmonary and dermatological manifestations. Occasionally muscle symptoms are observed as well. Read More

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http://dx.doi.org/10.31138/mjr.31.1.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219642PMC

Combined ultrasound-CT approach to monitor acute exacerbation of interstitial lung disease.

Ultrasound J 2020 May 15;12(1):27. Epub 2020 May 15.

Anaesthesia and Intensive Care, San Matteo Hospital, Viale Golgi 19, Pavia, Italy.

Background: Lung ultrasound is a bedside non-irradiating tool for assessment and monitoring of lung diseases. A lung ultrasound score based on visualized artefacts allows reliable quantification of lung aeration, and is useful to monitor mechanical ventilation setting, fluid resuscitation and antibiotic response in critical care. In the context of interstitial lung diseases associated to connective tissue disorders, lung ultrasound has been integrated to computed tomography for diagnosis and follow-up monitoring of chronic lung disease progression. Read More

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http://dx.doi.org/10.1186/s13089-020-00174-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224726PMC

Rationale for and clinical development of anti-fractalkine antibody in rheumatic diseases.

Expert Opin Biol Ther 2020 May 13:1-11. Epub 2020 May 13.

Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.

: Rheumatic diseases are inflammatory diseases that damage target organs via multiple subsets of immune cells. Fractalkine (FKN) acts as chemoattractant as well as adhesion molecule. It contributes to the pathogenesis of rheumatoid arthritis (RA) and other rheumatic diseases through multiple mechanisms: the migration of monocytes and cytotoxic effector T cells, the proliferation and activation of fibroblast-like synoviocytes, angiogenesis, and osteoclastogenesis. Read More

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http://dx.doi.org/10.1080/14712598.2020.1764931DOI Listing

External validation of EULAR/ACR classification criteria for idiopathic inflammatory myopathies.

Ann Rheum Dis 2020 May 12. Epub 2020 May 12.

Department of Rheumatology, John Hunter Hospital, New Lambton Heights, New South Wales, Australia.

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http://dx.doi.org/10.1136/annrheumdis-2020-217568DOI Listing

Lung involvement associated with anti-NXP2 autoantibodies in inflammatory myopathies: a French monocenter series.

Expert Rev Respir Med 2020 May 12. Epub 2020 May 12.

Assistance Publique Hôpitaux de Marseille. Hôpital Nord. Service de Pneumologie, Centre de Compétence national des maladies pulmonaires rares, Marseille, France.

: Idiopathic inflammatory myopathies (IIM) are characterized by muscular inflammation that can be associated with systemic disorders including lung. Anti-NXP2 antibody is a rare myositis-specific antibody and its association with pulmonary involvement is still unknown. In this study we investigated the characteristics of lung disease in patients with IMM associated with anti-NXP2 Ab. Read More

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http://dx.doi.org/10.1080/17476348.2020.1767598DOI Listing

Performance evaluation of a commercial line blot assay system for detection of myositis- and systemic sclerosis-related autoantibodies.

Clin Rheumatol 2020 May 8. Epub 2020 May 8.

Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan.

Introduction/objectives: A line blot (LB) assay is a multi-analyte platform capable of simultaneously detecting multiple anti-nuclear antibody specificities. Here, we evaluated the performance of a commercial LB assay developed for the identification of myositis- or systemic sclerosis (SSc)-related autoantibodies (autoAbs).

Method: We screened 300 serum samples from patients with various connective tissue diseases using an LB assay and compared the results of myositis- or SSc-related autoAbs with those identified by RNA and protein immunoprecipitation (IP) assays or indirect immunofluorescence (IIF). Read More

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http://dx.doi.org/10.1007/s10067-020-04973-0DOI Listing

The impact of hydroxychloroquine shortages on patients with dermatological conditions during COVID-19 pandemic.

Dermatol Ther 2020 May 7. Epub 2020 May 7.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/dth.13524DOI Listing

Rebound-associated vertebral fractures may occur in sequential time points following denosumab discontinuation: need for prompt treatment re-initiation.

Bone Rep 2020 Jun 22;12:100267. Epub 2020 Apr 22.

Department of Rheumatology, 417 "NIMTS", Army Shared Fund Hospital, Athens, Greece.

Denosumab discontinuation has been associated with increased risk of rebound-associated multiple vertebral fractures. We report the cases of three patients, two females and one male, who had manifested rebound-associated vertebral fractures after denosumab discontinuation and sustained new vertebral fractures a few months later. Two of the patients had been previously treated with bisphosphonates. Read More

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http://dx.doi.org/10.1016/j.bonr.2020.100267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191536PMC

'Shawl Sign' as a Paraneoplastic Dermatosis.

Cureus 2020 Apr 1;12(4):e7498. Epub 2020 Apr 1.

Family Medicine, Southern Illinois University School of Medicine, Springfield, USA.

Dermatomyositis (DM) is an idiopathic condition characterized by inflammation of muscles and skin lesions. It is often a paraneoplastic manifestation of internal malignancy. Hence, early recognition of this disorder is important. Read More

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http://dx.doi.org/10.7759/cureus.7498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195204PMC

Etiologies and outcomes of rheumatology patients with acute respiratory failure requiring intensive care: a single-center medical records review study of 259 patients.

Clin Rheumatol 2020 May 6. Epub 2020 May 6.

Department of Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objective: The etiologies of acute respiratory failure in patients with systemic rheumatic diseases (SRDs) requiring intensive care remain unknown. This study was undertaken to investigate the etiologies and outcomes.

Methods: A medical records review study was performed of 259 adult SRDs patients with respiratory failure admitted to medical ICU across a 5-year period. Read More

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http://dx.doi.org/10.1007/s10067-020-05080-wDOI Listing
May 2020
1.774 Impact Factor

An exploratory study of contractile force production in muscle fibers from patients with inflammatory myopathies.

Muscle Nerve 2020 May 5. Epub 2020 May 5.

Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, South Africa.

Introduction: The mechanism by which weakness develops in idiopathic inflammatory myopathies (IIMs) is still unclear. This study investigated the maximum force of single muscle fibers from patients with IIMs.

Methods: Permeabilized single muscle fibers from patients with IIMs and healthy controls were subjected to contractility measurements. Read More

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http://dx.doi.org/10.1002/mus.26904DOI Listing

Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies.

Front Cell Dev Biol 2020 17;8:226. Epub 2020 Apr 17.

Experimental Therapeutics Laboratory, University of South Australia Cancer Research Institute, Adelaide, SA, Australia.

Introduction: High Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus. We postulate aberrant HMGB1 expression in immune-mediated necrotising myopathy (IMNM).

Methods: Herein, we compare HMGB1 expression (serological and sarcoplasmic) in patients with IMNM with that of other myositis subtypes using immunohistochemistry and ELISA. Read More

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http://dx.doi.org/10.3389/fcell.2020.00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180187PMC

Efficacy of tofacitinib for slowly progressive interstitial lung disease in a patient with anti-MDA5 antibody-positive dermatomyositis.

Clin Immunol 2020 Apr 29;215:108451. Epub 2020 Apr 29.

Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

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http://dx.doi.org/10.1016/j.clim.2020.108451DOI Listing

Acquired reactive perforating collagenosis in association with prostate adenocarcinoma, chronic lymphocytic leukemia, and Graves' disease.

An Bras Dermatol 2020 Apr 18. Epub 2020 Apr 18.

Department of Dermatology and Venerology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Acquired reactive perforating collagenosis is a rare skin disorder characterized by the presence of umbilicated pruritic papules and nodules. Transepidermal elimination of altered and perforating bundles of basophilic collagen from the epidermis is a characteristic histologic feature of acquired reactive perforating collagenosis. Along with its well-known association with systemic diseases such as diabetes mellitus, chronic renal failure, and dermatomyositis, there are reports of acquired reactive perforating collagenosis being associated with malignancies. Read More

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http://dx.doi.org/10.1016/j.abd.2019.09.029DOI Listing

Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis.

J Rheumatol 2020 May 1. Epub 2020 May 1.

From the Schulich School of Medicine, University of Western Ontario, St. Joseph's Health Care, London, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Canadian Rheumatology Association Research studentship, University of Western Ontario. This funding was supported through the Canadian Rheumatology Association Roche summer studentship. There are no conflicts of interest. IRB was not necessary as this was a systematic literature review. Address correspondence to Dr. Janet Pope MD MPH FRCPC, Division of Rheumatology, St. Joseph's Health Care, 268 Grosvenor St. London ON N6A 4V2,

Objective: Rheumatoid Arthritis and other rheumatic diseases may present with ocular manifestations. The purpose of our work was to determine the prevalence and type of eye involvement in rheumatoid arthritis and other connective tissue diseases through a meta-analysis and literature review.

Methods: A systematic review of the literature was performed using Medline, Web of Science, and the Cochrane library from their inceptions until January 7, 2019. Read More

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http://dx.doi.org/10.3899/jrheum.190768DOI Listing

Immune Checkpoint Inhibitor-Related Myositis: From Biology to Bedside.

Int J Mol Sci 2020 Apr 26;21(9). Epub 2020 Apr 26.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "Guido Baccelli", University of Bari Medical School, 70124 Bari, Italy.

Immune checkpoint inhibitor (ICI)-related inflammatory diseases, including polymyositis (PM) and dermatomyositis (DM), in patients suffering from neoplastic disorders represent a medical challenge. The treatment of these conditions has taken on new urgency due to the successful and broad development of cancer-directed immunological-based therapeutic strategies. While primary and secondary PM/DM phenotypes have been pathophysiologically characterized, a rational, stepwise approach to the treatment of patients with ICI-related disease is lacking. Read More

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http://dx.doi.org/10.3390/ijms21093054DOI Listing

Macrophage activation syndrome in adult dermatomyositis: a case-based review.

Rheumatol Int 2020 Apr 30. Epub 2020 Apr 30.

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Macrophage activation syndrome (MAS) is a severe and life-threatening syndrome associated with autoimmune diseases, characterized by fever, hepatosplenomegaly, and pancytopenia. Dermatomyositis (DM) is one of the causes of MAS; however, its clinical characteristics in DM patients remain unclear. This study aimed to present a case of anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM complicated by MAS in a 29-year-old woman and to review the literatures including similar cases. Read More

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http://dx.doi.org/10.1007/s00296-020-04590-9DOI Listing

Case of anti-MDA-5 positive dermatomyositis with rapidly progressive interstitial lung disease.

BMJ Case Rep 2020 Apr 29;13(4). Epub 2020 Apr 29.

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1136/bcr-2020-235493DOI Listing

Successful treatment with baricitinb in a patient with refractory cutaneous dermatomyositis.

Rheumatology (Oxford) 2020 Apr 30. Epub 2020 Apr 30.

Rheumatology Department, IRCCS Policlinico S. Matteo Foundation, University of Pavia.

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http://dx.doi.org/10.1093/rheumatology/keaa184DOI Listing

Panniculitis as an Initial Presentation of Dermatomyositis: A Case Report.

JNMA J Nepal Med Assoc 2020 Mar;58(223):181-184

Department of Pathology, National Academy of Medical Sciences, Kathmandu, Nepal.

Dermatomyositis is an idiopathic muscle disease characterized by proximal muscle weakness, raised muscle enzymes, characteristic changes in electromyography and typical skin rash and biopsy findings. Dermatological features like Gottron's sign and papules are considered as pathognomonic for dermatomyositis. Panniculitis is one of the rare findings in dermatomyositis. Read More

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Weak Knees: A Case of Atorvastatin-induced Dermatomyositis.

Cureus 2020 Mar 24;12(3):e7387. Epub 2020 Mar 24.

Internal Medicine, Brookwood Baptist Medical Center, Birmingham, USA.

HMG-CoA reductase inhibitors (statins) are one of the most widely used medications in the primary care setting, and like any medications they have many side effects. The common ones include myalgias and rare ones include dermatomyositis. Here we present the case of atorvastatin-induced dermatomyositis with an unfortunate progression. Read More

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http://dx.doi.org/10.7759/cureus.7387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179976PMC

Myocarditis in a Patient With Clinically Amyopathic Dermatomyositis.

Circ J 2020 Apr 25. Epub 2020 Apr 25.

Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences.

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http://dx.doi.org/10.1253/circj.CJ-19-1046DOI Listing

Ovoid palatal patch: a clue to anti-TIF1γ dermatomyositis.

BMJ Case Rep 2020 Apr 23;13(4). Epub 2020 Apr 23.

Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

An 80-year-old woman presented with a several-year history of progressive hair loss and scalp pruritus. No other rashes or muscle weakness were noted on examination. Scalp biopsy showed interface dermatitis, dense perivascular and periadnexal lymphocytic infiltrate, mucin and scarring alopecia. Read More

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http://dx.doi.org/10.1136/bcr-2019-234111DOI Listing

Oedematous myositis: a clinical presentation first suggesting dermatomyositis diagnosis.

Brain Pathol 2020 Apr 22. Epub 2020 Apr 22.

Department of Internal Medicine and Clinical Immunology, National Reference Center of Neuromuscular disorders, APHP, Pitié-Salpêtrière University Hospital, Sorbonne University, University Pierre et Marie Curie, Paris, France.

Aims: Oedema of the limbs is uncommon in idiopathic inflammatory myopathies (IIM). The few reported cases have been associated with severe and refractory dermatomyositis (DM), sometimes in association with cancers. We aimed to determine if oedematous myositis is a homogeneous subtype based on clinical, serological and pathological features. Read More

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http://dx.doi.org/10.1111/bpa.12844DOI Listing

The clinical phenotype associated with antisynthetase autoantibodies.

Reumatologia 2020 28;58(1):4-8. Epub 2020 Feb 28.

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland.

Objectives: Specific systemic autoimmune syndrome characterized by inflammatory myopathy, arthritis or arthralgias, interstitial lung disease (ILD), fever, Raynaud's phenomenon, and mechanic's hands is called antisynthetase syndrome (AS). The aim of this study was to assess the clinical spectrum associated with presence of aminoacyl-transfer RNA synthetase autoantibodies (ASA).

Material And Methods: A total of 305 patients with presence of myositis-specific autoantibodies were identified in the database of immunological tests performed in the Clinical Immunology and Transplantology Unit, Medical University of Gdansk between January 2011 and March 2016. Read More

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http://dx.doi.org/10.5114/reum.2020.93505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174798PMC
February 2020

Imaging in dermatomyositis in adults and children.

J Ultrason 2020 31;20(80):e36-e42. Epub 2020 Mar 31.

Department of Musculoskeletal Radiology, Lille University Hospital , Lille , France.

Dermatomyositis is a rare autoimmune disorder in which an abnormal immune reaction against vascular endothelial antigens and endomysium leads to obstructive inflammatory changes of blood vessels within muscles, skin and other tissues. The disease is characterized by involvement of muscles, and less frequently of other systems, including the gastrointestinal tract, heart and lungs. Dermatomyositis may be diagnosed based on a detailed patient history, through clinical examination, detection of characteristic physical findings and certain specialized tests. Read More

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http://dx.doi.org/10.15557/JoU.2020.0007DOI Listing

Subcutaneous granuloma annulare mimicking dermatomyositis.

Pediatr Dermatol 2020 Apr 21. Epub 2020 Apr 21.

Department of Dermatology, The Faculty of Medicine, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.

We present three children who presented with papules and plaques over the knuckles, mimicking Gottron's papules of juvenile dermatomyositis, as well as subcutaneous nodules over the joints of the extremities that were initially thought to represent calcinosis cutis. However, thorough clinical and laboratory evaluation, as well as imaging, failed to support this diagnosis. Skin biopsies were consistent with a diagnosis of subcutaneous granuloma annulare. Read More

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http://dx.doi.org/10.1111/pde.14167DOI Listing

A Case of Dermatomyositis Along with Esophageal Cancer and Screening of Serum Transcriptional Intermediary Factor 1 Gamma Antibodies in Various Cancer Patients.

Am J Case Rep 2020 Apr 21;21:e922004. Epub 2020 Apr 21.

Department of Clinical Oncology, Toho University Graduate School of Medicine, Tokyo, Japan.

BACKGROUND Dermatomyositis (DM) is occasionally associated with malignancy, which is so-called cancer-associated myositis. The cancer screening in patients with dermatomyositis is an important clinical issue. That is because malignant disease underlying dermatomyositis is potentially life-threatening. Read More

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http://dx.doi.org/10.12659/AJCR.922004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193243PMC

Association of Dermatomyositis Sine Dermatitis and With Anti-Nuclear Matrix Protein 2 Autoantibodies.

JAMA Neurol 2020 Apr 20. Epub 2020 Apr 20.

Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

Importance: Reports on dermatomyositis (DM) sine dermatitis (DMSD) are scarce, and the concept of the disease has not been widely accepted.

Objective: To confirm the existence of DMSD, determine its prevalence, and characterize its serologic features.

Design, Setting, And Participants: This is a cohort study that reviewed clinical information, laboratory data, and muscle pathology slides from January 2009 to August 2019. Read More

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http://dx.doi.org/10.1001/jamaneurol.2020.0673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171574PMC

Polymyositis/dermatomyositis is a potential risk factor for acute respiratory failure: a pulmonary heart disease.

Ann Transl Med 2020 Mar;8(5):202

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung.

Background: Studies on the association between polymyositis/dermatomyositis (PM/DM) and acute respiratory failure (ARF) are considerably limited. We investigated whether ARF is associated with PM/DM using a nationwide cohort study.

Methods: We identified 1,374 patients with newly diagnosed PM/DM and 13,740 comparison individuals without PM/DM (non-PM/DM) randomly selected from the general population; frequency matched by age, sex, and index year using the National Health Insurance Research Database; and followed up until the end of 2011 to measure the incidence of ARF. Read More

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http://dx.doi.org/10.21037/atm.2020.01.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154474PMC

Acral Cutaneous Ulcerations and Livedo Reticularis with Rapidly Progressive Interstitial Lung Disease in Anti-MDA5 Antibody-Positive Classical Dermatomyositis.

Case Rep Dermatol 2020 Jan-Apr;12(1):57-63. Epub 2020 Mar 20.

Division of Rheumatology, Department of Medicine, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand.

Rapidly progressive interstitial lung disease (RP-ILD) and its distinctive cutaneous features are highly associated with the presence of anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody in patients with dermatomyositis (DM), leading to a poor prognosis. We describe the case of a 25-year-old man who developed progressive proximal muscle weakness with RP-ILD and had unusual cutaneous findings (cutaneous ulcerations and livedo reticularis) accompanied by classical cutaneous features (heliotrope rash, Gottron's papules, Gottron's sign, and flagellate erythema). Blood test was positive for anti-MDA5 antibody. Read More

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http://dx.doi.org/10.1159/000506668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154252PMC

[Dermatomyositis presenting with low back pain].

Agri 2020 Apr;32(2):99-102

Department of Physical Medicine and Rehabilitation, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.

Dermatomyositis (DM) is a rare connective tissue disease characterized by skin lesions and inflammatory changes observed in muscle biopsy findings. A definitive diagnosis of DM requires a characteristic rash in addition to proximal muscle weakness and muscle enzyme level elevation. DM is twice as common in women as men, with an age of onset of approximately 50 years. Read More

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http://dx.doi.org/10.5505/agri.2018.45578DOI Listing

Gasdermine E-Dependent Mitochondrial Pyroptotic Pathway in Dermatomyositis: A Possible Mechanism of Perifascicular Atrophy.

J Neuropathol Exp Neurol 2020 May;79(5):551-561

Department of Neurology, Qilu Hospital (Qingdao), Qingdao, Shandong, China.

Different mechanisms have been proposed to explain the pathological basis of perifascicular atrophy (PFA), a pathognomonic histologic feature of dermatomyositis (DM); however, the detailed mechanisms remain to be elucidated. There is mitochondrial dysfunction in PFA and expression of mitochondrial apoptosis molecules has been reported in DM. Overexpression of gasdermin E (GSDME) can turn mitochondrial apoptosis to mitochondrial pyroptosis, a newly characterized form of programmed cell death. Read More

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http://dx.doi.org/10.1093/jnen/nlaa023DOI Listing

Functional Index-3: A Valid and Reliable Functional Outcome Assessment Measure in Dermatomyositis and Polymyositis Patients.

J Rheumatol 2020 Apr 15. Epub 2020 Apr 15.

From the Division of Rheumatology, Department of Medicine, Mayo Clinic in Rochester, MN; Arthritis Associates and Osteoporosis Center of Colorado Springs, Colorado Springs, Colorado 80920; Department of Health Science Research, Division of Biostatistics, Mayo Clinic in Rochester, Minnesota; University of California at Los Angeles, Los Angeles CA; Division of Rheumatology, Department of Medicine, Beacon Hospital, Sandyford, Dublin 18, Ireland; Department of Neurobiology, Care Science and Society, Division of Physiotherapy, and Department of Medicine, Division of Rheumatology Karolinska Institutet, and Function Area Occupational Therapy and Physical Therapy, Karolinska University Hospital, Solna, Stockholm, Sweden. Address correspondence to Floranne Ernste, MD 200 First Street SW Rochester, MN 55905.Email:

Objective: Patients with dermatomyositis (DM) and polymyositis (PM) have reduced muscle endurance. The aim of this study was to streamline the Functional Index-2 (FI-2) by developing the Functional Index-3 (FI-3) and to evaluate its measurement properties, content and construct validity, intra- and inter-rater reliability.

Methods: A data set of the previously performed and validated FI-2 (n=63) was analyzed for internal redundancy, floor and ceiling effects. Read More

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http://dx.doi.org/10.3899/jrheum.191374DOI Listing