303 results match your criteria Dermatology and Therapy [Journal]


Review of Clinical Evidence over 10 Years on Prevention and Treatment of a Film-Forming Medical Device Containing Photolyase in the Management of Field Cancerization in Actinic Keratosis.

Dermatol Ther (Heidelb) 2019 Apr 9. Epub 2019 Apr 9.

Dermatology Unit, Second University of Naples, Nuovo Policlinico (Edificio 9C), Via Pansini 5, 80131, Naples, Italy.

Actinic keratosis (AK) is a common pathology that afflicts sun-exposed areas of the skin. It predominantly affects older and fair-skinned individuals suggesting an accumulative damage attributable to chronic sun exposure. The prevalence of AK has risen in the past decades and is expected to continue to rise. Read More

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http://link.springer.com/10.1007/s13555-019-0294-1
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http://dx.doi.org/10.1007/s13555-019-0294-1DOI Listing
April 2019
2 Reads

Tolerability and Efficacy of a Medical Device Repairing Emollient Cream in Children and Adults with Mild to Moderate Atopic Dermatitis.

Dermatol Ther (Heidelb) 2019 Apr 9. Epub 2019 Apr 9.

Clinical Skin Research and Development Center, Hôtel Dieu, Pierre Fabre Dermo-Cosmétique, Toulouse, France.

Introduction: Regular emollient application is recommended for managing atopic dermatitis (AD). Although many emollients are available, only AD-tested medical device repairing emollient creams (MDRECs) can be recommended for treating and preventing AD skin lesions. Here, we evaluated the tolerability and benefit of a new MDREC in an open-label study in infants, young children, and adults with mild to moderate AD. Read More

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http://dx.doi.org/10.1007/s13555-019-0295-0DOI Listing

Real-World, Non-Interventional, Observational Study of Hydroxyzine Hydrochloride in Chronic Pruritus: a Prospective, Non-Comparative Study.

Dermatol Ther (Heidelb) 2019 Apr 4. Epub 2019 Apr 4.

Medical Affairs, Dr. Reddy's Laboratories Ltd., Hyderabad, Telangana, India.

Introduction: Although hydroxyzine is widely used for symptom relief in pruritus, its clinical safety and efficacy data in the Indian setting are scarce. We conducted a study to assess the effectiveness and tolerability of hydroxyzine in the management of Indian patients with chronic pruritus in a real-world setting.

Methods: This was a prospective, observational, patient-reported outcomes (PRO) study in patients with chronic pruritus due to dermatological causes treated with hydroxyzine as per the clinician's discretion for a period of up to 12 weeks. Read More

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http://dx.doi.org/10.1007/s13555-019-0293-2DOI Listing
April 2019
2 Reads

Cost-Effectiveness of the Adjuvant Recombinant Zoster Vaccine in Japanese Adults Aged 65 Years and Older.

Dermatol Ther (Heidelb) 2019 Mar 30. Epub 2019 Mar 30.

Department of Dermatology, Aichi Medical University, Aichi, Japan.

Introduction: The incidence of herpes zoster (HZ) rises steeply after the age of 50 years and the number of HZ cases and complications such as postherpetic neuralgia (PHN) is predicted to increase because of the ageing population. The objective of this study was to estimate the cost-effectiveness of recombinant zoster vaccine (RZV) compared with no vaccine for the Japanese population aged ≥ 65 years.

Methods: A multi-cohort static Markov model with a cycle length of 1 year was used to follow a hypothetical cohort of 1 million people aged ≥ 65 years over their remaining lifetime. Read More

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http://dx.doi.org/10.1007/s13555-019-0291-4DOI Listing
March 2019
1 Read

Beyond PD-1 Immunotherapy in Malignant Melanoma.

Dermatol Ther (Heidelb) 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, University of Rzeszow, Rzeszów, Poland.

For many years, the standard therapy for malignant melanoma was based mainly on surgical resection. Unfortunately, this treatment is curative only in the early localized stage of this malignancy. The metastatic stage of malignant melanoma still remains a huge therapeutic challenge. Read More

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http://dx.doi.org/10.1007/s13555-019-0292-3DOI Listing

The Potential Benefits of Certolizumab Pegol in Patients with Concurrent Psoriatic Arthritis and Chronic Plaque Psoriasis: A Case Series and Review of the Literature.

Dermatol Ther (Heidelb) 2019 Mar 16. Epub 2019 Mar 16.

The Dermatology Centre, Salford Royal NHS Foundations Trust, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Introduction: We review the literature evaluating certolizumab in psoriasis and report our experience of treatment outcomes in a joint dermatology and rheumatology clinic.

Methods: Patients with concomitant psoriatic arthritis (PsA) and psoriasis who had been commenced on certolizumab were included within our retrospective review. Data was collected for patient demographics, Patient Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI) and previous treatments. Read More

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http://dx.doi.org/10.1007/s13555-019-0290-5DOI Listing
March 2019
3 Reads

Understanding the Burden of Atopic Dermatitis in Africa and the Middle East.

Dermatol Ther (Heidelb) 2019 Mar 8. Epub 2019 Mar 8.

Department of Dermatology and HMC Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.

Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intensely pruritic lesions. The prevalence of atopic dermatitis is increasing in developing regions, including Africa and the Middle East. However, these regions are underrepresented in the dermatology literature, and a better understanding of the growing burden of atopic dermatitis in Africa and the Middle East is necessary. Read More

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http://dx.doi.org/10.1007/s13555-019-0285-2DOI Listing

Correction to: Efficacy and Tolerability of a Medical Device Repairing Emollient Cream Associated with a Topical Corticosteroid in Adults with Atopic Dermatitis: An Open-label, Intra-individual Randomized Controlled Study.

Dermatol Ther (Heidelb) 2019 Mar 1. Epub 2019 Mar 1.

Clinical Skin Research and Development Center, Pierre Fabre Dermo-Cosmétique, 2 Rue Viguerie, Hotel Dieu, Toulouse, France.

The original article can be found online. Read More

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http://dx.doi.org/10.1007/s13555-019-0289-yDOI Listing
March 2019
2 Reads

Merkel Cell Carcinoma: Therapeutic Update and Emerging Therapies.

Dermatol Ther (Heidelb) 2019 Feb 28. Epub 2019 Feb 28.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico, Naples, Italy.

Merkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine skin cancer whose incidence has almost doubled in recent decades. Risk factors for MCC include age > 65 years, immunosuppression, sun exposure and infection by Merkel cell polyomavirus. MCC usually presents as rapidly growing, firm, red to violaceous nodule localized on the sun-exposed skin. Read More

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http://link.springer.com/10.1007/s13555-019-0288-z
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http://dx.doi.org/10.1007/s13555-019-0288-zDOI Listing
February 2019
5 Reads

Successful Treatment of Generalized Eruptive Keratoacanthoma of Grzybowski with Acitretin.

Dermatol Ther (Heidelb) 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.

Introduction: Keratoacanthomas (KA) are common cutaneous skin tumors originating from the hair follicles. Unlike squamous cell carcinoma, KA can regress spontaneously and have a benign evolution. Solitary KA is the most common form but familial multiple KA (Ferguson-Smith type), genetically predisposed KA (such as in xeroderma pigmentosum, or Muir-Torre syndrome), or sporadic multiple eruptive KA (Grzybowski type) have been described. Read More

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http://dx.doi.org/10.1007/s13555-019-0287-0DOI Listing
February 2019
5 Reads

Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience.

Dermatol Ther (Heidelb) 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

Introduction: Keratoacanthomas are cutaneous neoplasms known for their rapid growth and spontaneous regression over a long time period. Their treatment can be difficult because of the potentially large field size and number of lesions. Intralesional methotrexate constitutes an effective, nonsurgical treatment of keratoacanthomas, as proven by our experience. Read More

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http://dx.doi.org/10.1007/s13555-019-0286-1DOI Listing
February 2019

Adverse Events from Emollient Use in Eczema: A Restricted Review of Published Data.

Dermatol Ther (Heidelb) 2019 Feb 15. Epub 2019 Feb 15.

Population Health Sciences, University of Bristol, Bristol, UK.

Atopic dermatitis/eczema is a chronic inflammatory skin condition, and emollients are the first-line treatment. Despite their widespread use, there is uncertainty about the frequency and type of adverse events associated with different emollients. We conducted a restricted review of published data on adverse events associated with emollient use in eczema. Read More

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http://dx.doi.org/10.1007/s13555-019-0284-3DOI Listing
February 2019
1 Read

A Summary of 2018 and What Lies Ahead for Dermatology and Therapy in 2019.

Dermatol Ther (Heidelb) 2019 Mar 15;9(1):1-3. Epub 2019 Feb 15.

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR BRC, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s13555-019-0283-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380971PMC
March 2019
2 Reads

Tolerability of Topical Treatments for Atopic Dermatitis.

Dermatol Ther (Heidelb) 2019 Mar 24;9(1):71-102. Epub 2019 Jan 24.

Pfizer Inc., San Francisco, CA, USA.

Atopic dermatitis (AD) is a common inflammatory skin disease that is accompanied by increased sensitivity to itch-provoking and pain-provoking stimuli. Patients with AD experience skin pain before initiation of therapy and have also reported painful application site reactions in clinical trials of emollients and prescription topical therapies, including topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and a topical phosphodiesterase 4 (PDE4) inhibitor. To compare the sensory tolerability of prescription topical therapies for AD, a comprehensive literature search and analysis of published clinical trials was conducted. Read More

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http://link.springer.com/10.1007/s13555-019-0280-7
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http://dx.doi.org/10.1007/s13555-019-0280-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380975PMC
March 2019
4 Reads

New Vision in Photoprotection and Photorepair.

Dermatol Ther (Heidelb) 2019 Mar 23;9(1):103-115. Epub 2019 Jan 23.

Policlinique de Dermatologie, Hôpital Saint Louis, Paris, France.

Chronic exposure to solar radiation is associated with an increased incidence of skin cancer worldwide and more specifically with non-melanoma skin cancers and actinic keratosis. At the cellular level DNA damage is the main event following ultraviolet (UV) exposure. The kind of lesions produced depends on the wavelength and the energy profile of the radiation, with different photoproducts being formed as a result. Read More

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http://dx.doi.org/10.1007/s13555-019-0282-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380982PMC
March 2019
6 Reads

Self-Assessments of Standardized Scalp Massages for Androgenic Alopecia: Survey Results.

Dermatol Ther (Heidelb) 2019 Mar 22;9(1):167-178. Epub 2019 Jan 22.

Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, CA, USA.

Introduction: Standardized scalp massages (SSMs) improve hair thickness in nonbalding men, but their effects on androgenic alopecia (AGA) have not yet been evaluated. The objective of this study was to investigate the effect of SSMs on self-assessed AGA sufferers (SAGASs).

Methods: Between October 2016 and October 2017, 1899 SAGASs searching online for hair loss treatments beyond AGA management drugs accessed literature explaining SSMs as a potential therapy for AGA, then watched a demonstration video detailing twice-daily, 20-min SSMs segmented by three rotational scalp regions using hand-generated presses, pinches, and stretches. Read More

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http://dx.doi.org/10.1007/s13555-019-0281-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380978PMC
March 2019
9 Reads

Clinical Goals and Barriers to Effective Psoriasis Care.

Dermatol Ther (Heidelb) 2019 Mar 21;9(1):5-18. Epub 2018 Dec 21.

Harvard Medical Faculty Physicians, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Engaging global key opinion leaders, the International Psoriasis Council (IPC) held a day-long roundtable discussion with the primary purpose to discuss the treatment goals of psoriasis patients and worldwide barriers to optimal care. Setting clear expectations might ultimately encourage undertreated psoriasis patients to seek care in an era in which great gains in therapeutic efficacy have been achieved. Here, we discuss the option for early treatment of all categories of psoriasis to alleviate disease impact while emphasizing the need for more focused attention for psoriasis patients with mild and moderate forms of this autoimmune disease. Read More

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http://link.springer.com/10.1007/s13555-018-0279-5
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http://dx.doi.org/10.1007/s13555-018-0279-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380974PMC
March 2019
10 Reads

The Role of Vitamins and Minerals in Hair Loss: A Review.

Dermatol Ther (Heidelb) 2019 Mar 13;9(1):51-70. Epub 2018 Dec 13.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.

People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Read More

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http://link.springer.com/10.1007/s13555-018-0278-6
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http://dx.doi.org/10.1007/s13555-018-0278-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380979PMC
March 2019
31 Reads

Propionibacterium (Cutibacterium) acnes Bacteriophage Therapy in Acne: Current Evidence and Future Perspectives.

Dermatol Ther (Heidelb) 2019 Mar 11;9(1):19-31. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. Read More

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http://dx.doi.org/10.1007/s13555-018-0275-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380980PMC
March 2019
3 Reads

Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence.

Dermatol Ther (Heidelb) 2019 Mar 11;9(1):33-49. Epub 2018 Dec 11.

Department of Plastic Surgery, Tan Tock Seng Hospital, Singapore, Republic of Singapore.

Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. Read More

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http://dx.doi.org/10.1007/s13555-018-0277-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380977PMC
March 2019
8 Reads

Clinical and Biophysical Outcomes of Combining Microfocused Ultrasound with Visualization and Calcium Hydroxylapatite Filler for Facial Treatment.

Dermatol Ther (Heidelb) 2019 Mar 8;9(1):135-142. Epub 2018 Dec 8.

Merz Pharmaceuticals, Frankfurt, Germany.

Introduction: Combined cosmetic treatments are becoming increasingly popular. The objective of this clinical evaluation was to assess the long-term safety and efficacy of combining microfocused ultrasound with visualization (MFU-V) treatment with a calcium hydroxylapatite (CaHA) dermal filler to tighten skin at the submental region and contour the jawline.

Methods: Women with loss of contour and skin laxity in the lower face received MFU-V treatment. Read More

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http://dx.doi.org/10.1007/s13555-018-0273-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380976PMC
March 2019
18 Reads

Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis.

Dermatol Ther (Heidelb) 2019 Mar 7;9(1):159-166. Epub 2018 Dec 7.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Introduction: Erysipelas and bacterial cellulitis are two of the most common infectious skin diseases. They are usually caused by the β-hemolytic group of Streptococcus, and less frequently by other bacteria. The objective of the study was to assess the factors affecting the length of stay of patients admitted to hospital with erysipelas or bacterial cellulitis. Read More

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http://dx.doi.org/10.1007/s13555-018-0276-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380973PMC
March 2019
5 Reads

Efficacy and Safety of a Water-Based Head Lice Lotion: A Randomized, Controlled, Investigator-Blinded, Comparative, Bicentric Study.

Dermatol Ther (Heidelb) 2019 Mar 30;9(1):143-157. Epub 2018 Nov 30.

Adriaens Consulting, Bellemdorpweg 95, 9881, Bellem, Oost-Vlaanderen, Belgium.

Introduction: Silicones (e.g., dimethicone) are effective and safe alternatives to insecticides for the treatment of head lice. Read More

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http://dx.doi.org/10.1007/s13555-018-0274-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380969PMC
March 2019
5 Reads

A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum.

Authors:
Philip R Cohen

Dermatol Ther (Heidelb) 2019 Mar 26;9(1):185-192. Epub 2018 Nov 26.

San Diego Family Dermatology, National City, CA, USA.

Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Read More

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http://link.springer.com/10.1007/s13555-018-0272-z
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http://dx.doi.org/10.1007/s13555-018-0272-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380972PMC
March 2019
12 Reads

Impact of Ixekizumab Treatment on Itch and Psoriasis Area and Severity Index in Patients with Moderate-to-Severe Plaque Psoriasis: An Integrated Analysis of Two Phase III Randomized Studies.

Dermatol Ther (Heidelb) 2018 Dec 21;8(4):621-637. Epub 2018 Nov 21.

Department of Dermatology, University of Muenster, Muenster, Germany.

Introduction: We evaluated baseline itch and its impact on the efficacy of ixekizumab (IXE) in clearing psoriasis and improving quality-of-life measures, and we explored the relationship between itch and psoriatic skin improvement.

Methods: Data were analyzed from two double-blind, randomized, controlled phase III studies (UNCOVER-2/3) comparing etanercept (ETN), IXE, and placebo (PBO) in patients with moderate-to-severe plaque psoriasis. Long-term analysis included UNCOVER-3 data from week 0 to week 156. Read More

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http://dx.doi.org/10.1007/s13555-018-0267-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261114PMC
December 2018
11 Reads

Burden of Herpes Zoster in the Japanese Population with Immunocompromised/Chronic Disease Conditions: Results from a Cohort Study Claims Database from 2005-2014.

Dermatol Ther (Heidelb) 2019 Mar 19;9(1):117-133. Epub 2018 Nov 19.

Healthoutcomes Department, GSK, Tokyo, Japan.

Introduction: The aim of this study is to describe the disease burden and costs of herpes zoster (HZ) in the general adult Japanese population or patients with immunocompromised (IC) conditions or chronic disorders.

Methods: A retrospective cohort study of individuals aged 18-74 years was conducted using January 2005 to December 2014 records from the Japan Medical Data Center claims database. Twenty-eight IC conditions and chronic disorders were defined by diagnosis codes and/or procedures/treatments. Read More

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http://dx.doi.org/10.1007/s13555-018-0268-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380970PMC
March 2019
5 Reads

A Simulation-Based Workshop to Improve Dermatologists' Communication Skills: A Pilot for Continuing Medical Education.

Dermatol Ther (Heidelb) 2019 Mar 17;9(1):179-184. Epub 2018 Nov 17.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Introduction: Communication skills influence the quality of health care and patient experience; both may affect provider reimbursement. There are few opportunities available for practicing physicians to receive direct feedback on communication in patient encounters. The purpose of this simulation-based patient encounter workshop was for dermatologists to practice and obtain feedback on their communication skills. Read More

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http://dx.doi.org/10.1007/s13555-018-0270-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380981PMC
March 2019
13 Reads

A Case of Acute Pemphigus Vulgaris Relapses Associated with Cocaine Use and Review of the Literature.

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):653-663. Epub 2018 Nov 10.

Department of Neurology, Alzheimer Research Center Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Pemphigus is a bullous autoimmune disease that affects the skin and mucous membranes. It is very difficult to establish the etiology and the triggering factors that influence reactivations in pemphigus vulgaris (PV). The case of a 33-year-old male with chronic history of intranasal cocaine consumption is presented in this report. Read More

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https://www.researchgate.net/publication/242652021_Pemphigus
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http://link.springer.com/10.1007/s13555-018-0271-0
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http://dx.doi.org/10.1007/s13555-018-0271-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261113PMC
December 2018
19 Reads

Scoping Review on Use of Drugs Targeting Interleukin 1 Pathway in DIRA and DITRA.

Dermatol Ther (Heidelb) 2018 Dec 3;8(4):539-556. Epub 2018 Nov 3.

Immune-Mediated Inflammatory Skin Disease Research Group, IMIBIC/Reina Sofía University Hospital/University of Córdoba, Avenida Menéndez Pidal, Córdoba, 14004, Spain.

Introduction: Deficiencies in interleukin (IL)-1 receptor (IL-R) antagonist (DIRA) and IL-36R antagonist (DITRA) are rare genetic autoinflammatory diseases related to alterations in antagonists of the IL-1 pathway. IL-1 antagonists may represent therapeutic alternatives. Here, we aim to provide a scoping review of knowledge on use of IL-1-targeting drugs in DIRA and DITRA. Read More

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http://link.springer.com/10.1007/s13555-018-0269-7
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http://dx.doi.org/10.1007/s13555-018-0269-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261121PMC
December 2018
17 Reads

Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families.

Dermatol Ther (Heidelb) 2018 Dec 22;8(4):605-619. Epub 2018 Oct 22.

Anacor Pharmaceuticals, Inc., a wholly owned subsidiary of Pfizer Inc., New York, NY, USA.

Introduction: The impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase 3 studies (AD-301: NCT02118766; AD-302: NCT02118792, both at http://www.clinicaltrials.gov ). Read More

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http://link.springer.com/10.1007/s13555-018-0263-0
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http://dx.doi.org/10.1007/s13555-018-0263-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261115PMC
December 2018
13 Reads

Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis.

Dermatol Ther (Heidelb) 2018 Dec 20;8(4):593-604. Epub 2018 Oct 20.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Introduction: Psoriatic arthritis (PsA) is a chronic, inflammatory arthritis that affects an estimated 30% of patients with psoriasis. PsA is underdiagnosed in primary care and dermatology clinics due to a variety of reasons, including failure of healthcare providers to ask about symptoms, overlap of symptoms and signs with other rheumatologic conditions, and lack of a specific diagnostic test. A delay in PsA diagnosis and treatment, even as short as 6 months, can lead to decreased quality of life, increased joint damage, and worse long-term physical function. Read More

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http://link.springer.com/10.1007/s13555-018-0266-x
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http://dx.doi.org/10.1007/s13555-018-0266-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261122PMC
December 2018
17 Reads

Secukinumab is Superior to Ustekinumab in Clearing Skin in Patients with Moderate to Severe Plaque Psoriasis (16-Week CLARITY Results).

Dermatol Ther (Heidelb) 2018 Dec 17;8(4):571-579. Epub 2018 Oct 17.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, has demonstrated superior efficacy to ustekinumab in the phase 3b CLEAR study of moderate to severe plaque psoriasis. Here, we report 16-week results from CLARITY, a second head-to-head trial comparing secukinumab with ustekinumab.

Methods: In the phase 3b CLARITY study, patients were randomized 1:1 to receive subcutaneous secukinumab 300 mg or ustekinumab per label. Read More

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http://link.springer.com/10.1007/s13555-018-0265-y
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http://dx.doi.org/10.1007/s13555-018-0265-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261116PMC
December 2018
12 Reads

The Comorbidity Burden of Hidradenitis Suppurativa in the United States: A Claims Data Analysis.

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):557-569. Epub 2018 Oct 10.

Global Health Economics and Outcomes Research, AbbVie Inc, North Chicago, IL, USA.

Introduction: Prior studies have reported that hidradenitis suppurativa (HS) is accompanied by a myriad of physical and mental conditions. However, given the small sample sizes and the limited number of pre-selected comorbidities, these studies do not provide a complete picture of the comorbidity burden of HS in the USA. Moreover, the relationship between HS severity and comorbidity burden has yet to be characterized. Read More

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http://link.springer.com/10.1007/s13555-018-0264-z
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http://dx.doi.org/10.1007/s13555-018-0264-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261111PMC
December 2018
17 Reads

A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate.

Dermatol Ther (Heidelb) 2018 Dec 25;8(4):647-651. Epub 2018 Sep 25.

Department of Dermatology, Farhat Hached University Hospital, Sousse, Tunisia.

Psoriasis is a chronic inflammatory disease affecting the skin, nails, and joints. About 61% of psoriatic patients have nail involvement that can cause a significant social problem. Treating nail psoriasis is challenging but can improve the health outcomes and quality of life of patients. Read More

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http://dx.doi.org/10.1007/s13555-018-0261-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261120PMC
December 2018
1 Read

Disease Burden and Treatment Patterns of Psoriasis in Russia: A Real-World Patient and Dermatologist Survey.

Dermatol Ther (Heidelb) 2018 Dec 19;8(4):581-592. Epub 2018 Sep 19.

Data Pyxis Ltd., St Albans, UK.

Introduction: Data regarding disease burden and quality of life (QoL) for patients with psoriasis from Russia are limited. The objective of this study was to describe the demographic and clinical characteristics, comorbidities, and treatment patterns of systemic therapy eligible psoriasis patients in Russia in order to assess the impact of psoriasis on the QoL and work productivity of the patients and to evaluate patient/dermatologist concordance on disease severity, signs/symptoms, and satisfaction with psoriasis treatment.

Methods: Data were collected by the Growth from Knowledge Disease Atlas global real-world evidence programme from nine countries. Read More

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http://dx.doi.org/10.1007/s13555-018-0262-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261112PMC
December 2018
1 Read

Acral Melanoma: A Patient's Experience and Physician's Commentary.

Dermatol Ther (Heidelb) 2018 Dec 18;8(4):503-507. Epub 2018 Sep 18.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, USA.

This article, co-authored by a patient diagnosed with acral melanoma, discusses the patient's experience of being diagnosed with and treated with surgery for this disease. The physician discusses the epidemiology, genetics, diagnosis, treatment, and prognosis of acral melanoma. Follow-up care plans are also discussed. Read More

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http://dx.doi.org/10.1007/s13555-018-0260-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261119PMC
December 2018
1 Read

Topical Selenium Sulfide for the Treatment of Hyperkeratosis.

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):639-646. Epub 2018 Sep 10.

University of California San Diego Hyperbaric Medicine and Wound Healing Center, Encinitas, CA, USA.

Hyperkeratosis presents as thickened skin. It can be congenital or acquired. Typically, it affects the palms and soles; the distribution of epidermal involvement is either diffuse, focal, or punctate. Read More

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http://link.springer.com/10.1007/s13555-018-0259-9
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http://dx.doi.org/10.1007/s13555-018-0259-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261123PMC
December 2018
11 Reads

Treatment of Atopic Dermatitis with Biologic Drugs.

Dermatol Ther (Heidelb) 2018 Dec 4;8(4):527-538. Epub 2018 Sep 4.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin disease which predominately affects children and usually clears up during infancy or childhood. However, AD may persist with a chronic relapsing course until adulthood or develop at a later age. AD treatment can often be complicated. Read More

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http://dx.doi.org/10.1007/s13555-018-0258-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261117PMC
December 2018
15 Reads

Treatment of Genital Psoriasis: A Systematic Review.

Dermatol Ther (Heidelb) 2018 Dec 25;8(4):509-525. Epub 2018 Aug 25.

Department of Dermatology, UCSF Medical Center, San Francisco, CA, USA.

Genital psoriasis affects approximately 63% of psoriasis patients at least once in their lifetime. More than any other area on the body, genital lesions significantly impair patients' psychologic well-being and quality of life. We aimed to systematically review the published evidence on the safety, efficacy, and tolerability of treatments of genital psoriasis and synthesize the available clinical data. Read More

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http://dx.doi.org/10.1007/s13555-018-0257-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261118PMC
December 2018
20 Reads

Trichotillomania and Trichophagia: Modern Diagnostic and Therapeutic Methods.

Dermatol Ther (Heidelb) 2018 Sep 11;8(3):389-398. Epub 2018 Aug 11.

Department of Dermatology, University of Rzeszów, Rzeszów, Poland.

Trichotillomania is a chronic, mental disease of impulse control, characterized by repetitive, compulsive, and self-induced hair pulling. It can occur at any age but is observed more often in adolescents, with a strong predominance in females. Diagnosis of trichotillomania may be difficult, and its effective treatment challenging. Read More

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http://dx.doi.org/10.1007/s13555-018-0256-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109030PMC
September 2018
1 Read

A Rapid and Cost-Effective Device for Testing Minimal Erythema Dose.

Dermatol Ther (Heidelb) 2018 Sep 10;8(3):483-489. Epub 2018 Aug 10.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Introduction: We describe a novel device for rapid and economical minimal erythema dose testing in patients undergoing ultraviolet (UV) light phototherapy for treatment of skin diseases.

Methods: A minimal erythema testing device was designed and created using transparent plastic sheeting and printed patterns with increasing ink density, allowing for graded UV transmission of 100%, 80%, 60%, 40%, 20%, and 10% energy through six 10-mm square apertures. The plastic sheet was placed in a UV-impenetrable and Velcro-fitted adjustable sleeve, designed to fit easily onto a patient's arm. Read More

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http://dx.doi.org/10.1007/s13555-018-0255-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109034PMC
September 2018
1 Read

A Single-Arm, Open-Label, Phase IV Study to Evaluate the Efficacy of a Topical Formulation for Hyperkeratotic Actinic Keratosis Lesions.

Dermatol Ther (Heidelb) 2018 Sep 27;8(3):455-462. Epub 2018 Jul 27.

International Hair Research Foundation (IHRF), Milan, Italy.

Introduction: Actinic keratosis (AKs) are epidermal lesions that commonly occur in skin exposed to chronic cumulative UV irradiation. Untreated AK lesions can advance to squamous cell carcinoma. Current treatments of AK have many shortcomings; for instance, not all treatments can be used for the hyperkeratotic form of AK. Read More

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http://dx.doi.org/10.1007/s13555-018-0252-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109024PMC
September 2018
1 Read

Daily Application of an Aqueous, Acidifying, Peelable Nail Polish versus Weekly Amorolfine for Topical Onychomycosis Treatment: A Prospective, Randomized, Blinded Trial.

Dermatol Ther (Heidelb) 2018 Sep 26;8(3):463-473. Epub 2018 Jul 26.

Adriaens Consulting, Bellemdorpweg 95, 9881, Bellem, OVL, Belgium.

Introduction: Onychomycosis is a fungal nail infection, frequently caused by dermatophytes, which occurs in 2-14% of Western adults. The present study was set up to evaluate the efficacy and safety of a water-based, peelable nail polish (daily application), which acidifies the nail environment, versus a 5% amorolfine nail lacquer (weekly application) for topical treatment of mild-to-moderate onychomycosis.

Methods: One hundred two adults were randomized in this open, prospective, blinded trial. Read More

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http://dx.doi.org/10.1007/s13555-018-0254-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109032PMC
September 2018
3 Reads

Topical Application of 5-Fluorouracil Associated with Distant Seborrheic Dermatitis-like Eruption: Case Report and Review of Seborrheic Dermatitis Cutaneous Reactions after Systemic or Topical Treatment with 5-Fluorouracil.

Dermatol Ther (Heidelb) 2018 Sep 26;8(3):495-501. Epub 2018 Jul 26.

Department of Dermatology, University of California San Diego, La Jolla, CA, USA.

Introduction: 5-Fluorouracil is a fluoropyrimidine antineoplastic medication that is used to topically treat actinic keratoses. Although local adverse effects to the drug are common and anticipated, distant skin reactions are rare and unexpected. In this case report, we describe a patient who developed seborrheic dermatitis-like eruption at a distant site after topical application of 5-fluorouracil to his arms. Read More

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http://dx.doi.org/10.1007/s13555-018-0253-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109033PMC
September 2018
6 Reads

Effect of Prior Biologic Use on Cost-Effectiveness of Brodalumab vs. Ustekinumab for Treatment of Moderate-to-Severe Psoriasis in the United States.

Dermatol Ther (Heidelb) 2018 Sep 13;8(3):441-453. Epub 2018 Jul 13.

Novosys Health, Green Brook, NJ, USA.

Introduction: Clinical trials have shown brodalumab to have better efficacy than ustekinumab for the treatment of moderate-to-severe psoriasis. An estimation of the cost-effectiveness of brodalumab vs. ustekinumab is warranted and may be useful for treatment decision-making processes, especially in the context of the cost considerations of the current US healthcare system. Read More

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http://dx.doi.org/10.1007/s13555-018-0251-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109035PMC
September 2018
3 Reads

Patient Reported Improvement After Patch Testing and Allergen Avoidance Counseling: A Retrospective Analysis.

Dermatol Ther (Heidelb) 2018 Sep 9;8(3):435-440. Epub 2018 Jul 9.

Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.

Introduction: Our objectives were to assess patient-reported improvement after patch testing at the 2-3-month follow-up visit in patients referred for patch testing with relevant positive patch test reactions at the University of California, San Francisco.

Methods: Cross-sectional analyses of patients patch tested between 2013 and 2016 who returned for a follow-up visit approximately 2-3 months after patch testing. We examined positive patch test results considered of definite, probable or possible relevance to the patient's eczematous eruptions. Read More

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http://dx.doi.org/10.1007/s13555-018-0250-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109020PMC
September 2018
3 Reads

Topical Ivermectin in the Treatment of Papulopustular Rosacea: A Systematic Review of Evidence and Clinical Guideline Recommendations.

Dermatol Ther (Heidelb) 2018 Sep 25;8(3):379-387. Epub 2018 Jun 25.

Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands.

Introduction: Rosacea is a chronic inflammatory skin disease with different phenotypes. There is accumulating evidence that the commensal Demodex mite is linked to papulopustular rosacea. Established treatment options, including topical metronidazole, azelaic acid, and tetracyclines, are thought to work through their anti-inflammatory effects. Read More

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http://dx.doi.org/10.1007/s13555-018-0249-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109029PMC
September 2018
38 Reads

Efficacy Endpoints in Clinical Trials in Actinic Keratosis.

Dermatol Ther (Heidelb) 2018 Sep 18;8(3):425-433. Epub 2018 Jun 18.

Department of Dermatology, University of Miami Miller School of Medicine, Miami, USA.

Introduction: Actinic keratosis is regarded as a chronic disease of the skin and, although fluctuating, is chronically progressive. Approval of new products for the treatment of actinic keratosis requires the use of a standard methodology in clinical trials which emphasize complete clearance of all actinic keratoses in a treatment field in a defined time span and the evaluation of long-term efficacy in terms of recurrence rate among completely cleared patients.

Methods: Analysis of data from six previously published clinical trials in patients with actinic keratosis. Read More

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http://dx.doi.org/10.1007/s13555-018-0247-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109027PMC
September 2018
3 Reads

Development of Low-Cost Locally Sourced Two-Component Compression Bandages in Western Kenya.

Dermatol Ther (Heidelb) 2018 Sep 15;8(3):475-481. Epub 2018 Jun 15.

Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.

Introduction: Compression therapy is well-established standard of care for chronic leg ulcers from venous disease and lymphedema. Chronic leg ulcers and lymphedema have a significant impact on quality of life, driven by pain, foul odor, and restricted mobility. Provision of layered compression therapy in resource-limited settings, as in Western Kenya and other regions of sub-Saharan Africa, is a major challenge due to several barriers: availability, affordability, and access to healthcare facilities. Read More

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http://dx.doi.org/10.1007/s13555-018-0248-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109023PMC
September 2018
28 Reads

Building a Citizen Pscientist: Advancing Patient-Centered Psoriasis Research by Empowering Patients as Contributors and Analysts.

Dermatol Ther (Heidelb) 2018 Sep 6;8(3):405-423. Epub 2018 Jun 6.

Department of Dermatology, University of California San Francisco, San Francisco, USA.

Introduction: To design and implement a novel cloud-based digital platform that allows psoriatic patients and researchers to engage in the research process.

Methods: Citizen Pscientist (CP) was created by the National Psoriasis Foundation (NPF) to support and educate the global psoriatic disease community, where patients and researchers have the ability to analyze data. Psoriatic patients were invited to enroll in CP and contribute health data to a cloud database by responding to a 59-question online survey. Read More

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http://link.springer.com/10.1007/s13555-018-0242-5
Publisher Site
http://dx.doi.org/10.1007/s13555-018-0242-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109031PMC
September 2018
13 Reads