201,659 results match your criteria Dermatology and Therapy [Journal]


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J Am Acad Dermatol 2018 Dec 8. Epub 2018 Dec 8.

The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160. Electronic address:

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December 2018

The impact of integrin β2 on granulocyte/macrophage progenitor proliferation.

Stem Cells 2018 Dec 11. Epub 2018 Dec 11.

Beijing Key Laboratory od Diabetes Prevention and Research, Endocrinology Center, Lu He hospital, Capital Medical University, Beijing, China.

Rationale: Previously we reported that although the HSPC frequency in bone marrow cells (BMC) was comparable between β2-/- and β2+/+ mice, transplantation of β2-/- BMC into lethally irradiated CD45.1 recipient resulted in more myeloid cell production than β2+/+ BMC.

Objective: To address if integrin β2 deficiency skews granulocyte/macrophage progenitor (GMP) proliferation. Read More

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December 2018
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Pediatric Dermatology - critical approach to the new treatments.

Dermatol Ther 2018 Dec 7:e12801. Epub 2018 Dec 7.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health.

The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. Read More

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December 2018
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Allergic contact dermatitis due to undecylenic acid in an antifungal nail solution.

Contact Dermatitis 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Hospital General Universitario de Alicante. Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

Undecylenic acid (CAS no. 112-38-9) has antifungal and antibacterial effects. For this reason, it is used along with imidazole antifungals. Read More

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December 2018

Erster Fallbericht einer beidseitigen zirkumskripten Morphea des Gesichts.

J Dtsch Dermatol Ges 2018 Dec;16(12):1480-1482

Dermatology, Venereology and Leprosy, Ellahi Medicare Clinic, Kashmir, India.

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December 2018

Faziale Papeln bai follikulärem B-Zell-Lymphom.

J Dtsch Dermatol Ges 2018 Dec;16(12):1493-1495

Department of Dermatology and Venereology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

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December 2018

Rote und juckende bilaterale supraorbitale Schwellungen.

J Dtsch Dermatol Ges 2018 Dec;16(12):1503-1506

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Deutschland.

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December 2018

Nomenclature of cutaneous vasculitides - German translation of the dermatologic addendum to the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.

J Dtsch Dermatol Ges 2018 Dec;16(12):1425-1432

Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria.

The nomenclature system agreed upon by the Chapel Hill Consensus Conference (CHCC) with respect to the terminology and precise definition of the various types of vasculitis has gained widespread interdisciplinary and international acceptance. As the revised version from 2012 (CHCC 2012) does not address the special features of vasculitis of the skin, it has recently been supplemented with an addendum containing the nomenclature of cutaneous vasculitides (D-CHCC). The present article provides the German translation of the terms and defintions of the D-CHCC as well as additional explanatory comments. Read More

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December 2018
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Patterns of infiltration and local recurrences of various types of cutaneous sarcomas following three-dimensional histology.

J Dtsch Dermatol Ges 2018 Dec;16(12):1434-1442

Department of Dermatology, Eberhardt Karls University, Tübingen Germany.

Background: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure. Read More

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December 2018
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Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Service of Dermatology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain.

Background: Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC).

Objective: To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients. Read More

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December 2018
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Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus.

Microbiol Immunol 2018 Dec 11. Epub 2018 Dec 11.

Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.

Trichodysplasia spinulosa associated polyomavirus (TSPyV), a newly identified polyomavirus has been implicated as a causative agent of trychodysplasia spinulosa (TS), a rare proliferative skin disease in severly immunocompromised hosts. The diagnosis using monoclonal antibodies (mAbs) has been provided as a promising tool as it offers high specificity towards specific antigen. Till there is no good mAb available for diagnosis of TS disease. Read More

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December 2018
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CARD9 variants in Chinese patients with sporotrichosis.

J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan, China.

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December 2018
2 Reads

Charcoal pocket hand warmers - a rare cause of BCC carcinogenesis?

Australas J Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Department of Dermatology, Circle Treatment Centre, Nottingham, UK.

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December 2018

Classic pseudoxanthoma elasticum in a girl with sickle cell disease.

Pediatr Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Department of Dermatology and Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

A pseudoxanthoma elasticum (PXE)-like phenotype develops in a subset of patients with inherited hemoglobinopathies. Although PXE tissue changes are thought to develop in the absence of ABCC6 mutations in patients with beta-thalassemia, ABCC6 mutations have not been well evaluated among sickle cell disease patients with PXE-like disease. To our knowledge, we describe the first patient with sickle cell disease, PXE skin findings, and two confirmed pathogenic ABCC6 mutations. Read More

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December 2018
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Case of purpuric drug eruption probably induced by panitumumab.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

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December 2018

Multiple chemical sensitivity syndrome is not caused by contact allergy.

Contact Dermatitis 2018 Dec 10. Epub 2018 Dec 10.

Department of Cutaneous Allergy, St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust, London, UK.

There is a lack of published data on the role of patch testing in patients with so-called multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI). This disputed chronic condition is characterised by symptoms that the affected person attributes to low-level exposures to commonly used chemicals. Symptoms are typically vague and non-specific and may include fatigue, headaches, nausea, dizziness, a sensation of skin burning or pain. Read More

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December 2018
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Human polyomavirus 7 (HPyV7)-associated dermatoses: novel molecular mechanism driven by viral activation of 4E-BP1 and MEK-ERK-cJun.

Int J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, University of Texas Medical School, Houston, TX, USA.

A number of pruritic skin conditions arising in immunocompromised patients are associated with viral infection. Recently, human polyomavirus 7 (HPyV7) has been implicated in the pathogenesis of eruptive pruritic parakeratotic and dyskeratotic dermatoses with distinct "peacock plumage" histology. While expression of HPyV7 viral protein, namely small tumor (sT) antigen, is prominent within lesional tissue, the functional role of HPyV7 in cutaneous pathobiology is not yet known. Read More

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December 2018
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Successful sclerotherapy and psoriasis: A discussion of koebnerization, report of two cases, and review of the literature.

J Cosmet Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.

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December 2018

Cutaneous malignant melanoma of the oral cavity following skin graft reconstruction: Case report.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature.

Methods: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue.

Results: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Read More

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December 2018
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Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

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December 2018
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The impact of human herpesvirus detection in pemphigus vulgaris.

Australas J Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Department of Dermatology, The Royal Melbourne Hospital, Parkville, Victoria, Australia.

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December 2018
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Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung, 40402, Taiwan.

Skin evolves essential appendages and indispensable types of cells that synergistically insulate the body from environmental insults. Residing in the specific regions in the skin such as epidermis, dermis and hair follicle, melanocytes perform an array of vital functions including defending the ultraviolet radiation and diversifying animal appearance. As one of the adult stem cells, melanocyte stem cells in the hair follicle bulge niche can proliferate, differentiate, and keep quiescence to control and coordinate tissue homeostasis, repair, and regeneration. Read More

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December 2018
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Efficacy of topical dithranol (Dithrocream ) in the treatment of alopecia areata: a retrospective case series.

Authors:
A Daunton M Harries

Br J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

The Dermatology Centre, Salford Royal NHS Foundation Trust, Salford, U.K.

Topical dithranol is an alternative therapy to topical diphencyprone for extensive AA, with the advantage that it can be applied at home. It is also safe in children and has low risk for use during pregnancy. Its precise mechanism of action is unknown, but it is plausible that the local cytokine profile induced by its irritant effect "compete" with the inflammatory milieu incited during the inflammatory cell attack on hair follicles. Read More

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December 2018

Dermatitis and alopecia in a patient treated with dupilumab: a new adverse effect?

Clin Exp Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Department of Dermatology, Puerta de Hierro Hospital, C/Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain.

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December 2018

Ultrasound Elastography Images in Vascular Anomalies.

J Ultrasound Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology , Puerta de Hierro Universitary Hospital, Majadahonda, Madrid, Spain.

Ultrasound elastography is an emerging imaging technique that provides an objective method to assess the relative or absolute stiffness of soft tissues. The authors have not found any description in the use of ultrasound elastography in vascular anomalies, and we want to share our experience in different cases with ultrasound elastography and its applications in these pathologies. Read More

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December 2018
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Evaluation of long-term efficacy of finasteride in Korean men with androgenetic alopecia using the basic and specific classification system.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea.

Finasteride 1 mg is considered to be the standard treatment method for male androgenetic alopecia (AGA). However, there have only been a few studies investigating its long-term efficacy. Moreover, its effect on various types of AGA remains unknown. Read More

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December 2018

Case of hand, foot and mouth disease with vesicular Koebner phenomenon on the ankles caused by Coxsackievirus A6 in an adult.

J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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December 2018

Variability in the Diagnosis of Surgical Site Infections After Full-Thickness Skin Grafting: An International Survey.

Br J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Diagnosis of a surgical site infection (SSI) in dermatologic surgery can be entirely based on a subjective assessment according to the 4 criterion of the most common definition of an SSI, which was established by the US Centers for Disease Control (CDC).

Objectives: To investigate the interobserver agreement between dermatologists in their diagnosis of SSI of dermatosurgical wounds.

Methods: An international electronic photographic survey with eight photographs of wounds 1 week after full-thickness skin grafting (FTSG) was sent to dermatologists. Read More

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December 2018
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How often are bath emollients prescribed to children with atopic eczema in primary care in England? A cross-sectional study.

Br J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Centre of Evidence Based Dermatology, University of Nottingham, King's Meadow Campus, Lenton Lane, Nottingham, NG7 2NR.

Atopic eczema is one of the most burdensome skin diseases across the globe and affects up to 20% of children in the UK. The mainstay of treatment is regular use of emollients including leave-on emollients, soap substitutes and emollient bath additives. However, the lack of evidence to support the use of bath additives has led some to question their role in atopic eczema management. Read More

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December 2018
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Novel compound heterozygous FATP4 mutations caused ichthyosis prematurity syndrome in Spanish sisters.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Fundación Pública Galega de Medicina Xenómica-SERGAS, CIBERER, IDIS, Grupo de Medicina Xenómica-Universidade de Santiago de Compostela, Santiago de CompostelaSpain.

Ichthyosis prematurity syndrome (IPS), or ichthyosis congenita type IV, is a rare syndromic form of autosomic recessive ichthyosis caused by mutations in fatty acid transport protein 4 (FATP4), also known as SLC27A4. Patients with a disrupted FATP4 gene are usually born prematurely with thick desquamating skin and other complications, such as neonatal asphyxia, eosinophilia and elevated serum immunoglobulin E levels. Symptoms become less severe after the first months of life, evolving to non-scaly ichthyosis with follicular hyperkeratosis in adulthood (1, 2). Read More

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December 2018
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Cutaneous adult xanthogranuloma with a small portion of BRAF mutated Langerhans cell histiocytosis populations: A case report and the review of published work.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Histiocytoses, including Langerhans cell histiocytosis (LCH), juvenile or adult xanthogranuloma (AXG) and Rosai-Dorfman disease (RDD), are rare disorders characterized by the proliferation of cells derived from monocyte/macrophage lineages. A few cases of LCH coexisting with xanthogranuloma or RDD have been reported. The etiology of these diseases remains unclear. Read More

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December 2018

Recurrence of periocular basal and squamous cell carcinoma after Mohs Micrographic Surgery: a retrospective cohort study.

Br J Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Despite the widespread use of Mohs Micrographic Surgery (MMS) for periocular basal and squamous cell carcinoma (together called keratinocyte carcinoma (KC)), follow-up data regarding recurrences are limited.

Objectives: To investigate the recurrence rate for periocular KCs after MMS and describe experience with interdisciplinary collaborations.

Methods: Patients with periocular KCs treated with MMS between 2006 and 2016 in a tertiary MMS referral hospital were included in this retrospective cohort study. Read More

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December 2018

Risk of skin cancer in psoriasis patients receiving long-term narrowband ultraviolet phototherapy: results from a Taiwanese population-based cohort study.

Photodermatol Photoimmunol Photomed 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Taichung Veterans General Hospital, Taichung.

Background: Narrow-band ultraviolet B (NB-UVB) phototherapy is a widely used treatment for various dermatoses. The risk of skin cancer following long term NB-UVB phototherapy has rarely been explored in skin phototypes III-V.

Methods: We conducted a nationwide matched cohort study and identified a total of 22,891 psoriasis patients starting NB-UVB phototherapy from the Taiwan National Health Insurance Database during the period 2000-2013. Read More

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December 2018
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Evaluation of oral tranexamic acid in the treatment of melasma.

J Cosmet Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Universidade de Mogi das Cruzes, Dermatology, Mogi das Cruzes, Brazil.

Background: Melasma is an acquired, chronic, recurrent hypermelanosis that occurs exclusively in areas exposed to the sun. Its treatment can be very challenging. Tranexamic acid (TA) is an inhibitor of plasmin, and it is a synthetic derivative of the amino acid lysine that reversibly blocks binding sites on the plasminogen molecule, inhibiting the plasminogen activator from converting plasminogen to plasmin. Read More

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December 2018
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Isotretinoin and Candida immunotherapy for recalcitrant warts in solid organ transplant recipients.

Dermatol Ther 2018 Dec 10:e12803. Epub 2018 Dec 10.

Department of Dermatology, University of Florida.

Treatment of recalcitrant warts in solid organ transplant recipients (SOTR) can pose a therapeutic challenge for dermatologists. Successful treatment of recalcitrant warts can serve as secondary prevention for skin cancer in those with chronic immunosuppression. Given the heterogeneity of associated comorbid conditions in SOTR, clinical trials are difficult to conduct in this high-risk population, therefore, our clinical practice is mostly driven by observed responses from studies in immunocompetent patients or from case reports of immunocompromised patients. Read More

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December 2018
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Regression of multiple melanocytic nevi associated with nivolumab treatment for metastatic melanoma.

Int J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Clinical University Hospital of Valencia, Valencia, Spain.

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December 2018

DUSP22 promotes senescence of HS-1 skin cancer cells through triggering MAPK signaling pathway.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7819-7825

Department of Dermatology, The Fifth Affiliated Hospital of Harbin Medical University, Daqing, Heilongjiang, China.

Objective: Skin cancer severely threatens the public health. Dual-specificity protein phosphatase 22 (DUSP22) characterizes with multiple roles regulating cell growth, proliferation and gaining. This study aims to investigate the regulatory role of DUSP22 on aging of skin cancer cells and clarify molecular mechanisms, along with potential application value. Read More

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November 2018
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Real-World Use of Talimogene Laherparepvec in German Patients with Stage IIIB to IVM1a Melanoma: A Retrospective Chart Review and Physician Survey.

Adv Ther 2018 Dec 7. Epub 2018 Dec 7.

Amgen Ltd, Uxbridge, UK.

Introduction: Talimogene laherparepvec is a first-in-class oncolytic immunotherapy for intratumoral injection with proven efficacy and tolerability in patients with unresectable early metastatic melanoma (stage IIIB-IVM1a) in the pivotal phase III OPTiM study. The objective was to characterize melanoma patients treated with talimogene laherparepvec in routine clinical practice in Germany.

Methods: A retrospective chart review was conducted in unresectable stage IIIB-IVM1a melanoma patients. Read More

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December 2018

Clinicopathologic Characteristics and Prognosis Analysis of Marjolin's Ulcer in 40 Cases.

Curr Med Sci 2018 Dec 7;38(6):1038-1044. Epub 2018 Dec 7.

Department of Plastic Surgery, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Marjolin's ulcer (MU) is a rare but aggressive epidermoid carcinoma observed in scars or wounds. This article provides comprehensive characteristics and prognostic details of MU. Clinical data of 40 patients with MU between January 2010 and December 2017 were analyzed retrospectively. Read More

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December 2018
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JAK Inhibitors for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 5 E. 98th Street, New York, NY, 10029, USA.

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying degrees of Th1 and Th17 among various subtypes. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and spleen tyrosine kinase (SYK) pathways are involved in signaling of several AD-related cytokines, such as IFN-γ, IL-4, IL-13, IL-31, IL-33, IL-23, IL-22, and IL-17, mediating downstream inflammation and barrier alterations. Read More

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December 2018
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Mitochondrial Isolation and Real-Time Monitoring of MOMP.

Methods Mol Biol 2019 ;1877:121-130

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Isolated model systems have proven to be the standard in the apoptosis field to deconstruct MOMP into individual steps and to study the behavior of a subset of MOMP regulators. Here we describe the method to isolate, JC-1-label, and purify mouse liver mitochondria and subsequently describe how to utilize the JC-1-labeled mitochondria for real-time MOMP measurements. Read More

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January 2019

Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis.

Dermatol Ther (Heidelb) 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Introduction: Erysipelas and bacterial cellulitis are two of the most common infectious skin diseases. They are usually caused by the β-hemolytic group of Streptococcus, and less frequently by other bacteria. The objective of the study was to assess the factors affecting the length of stay of patients admitted to hospital with erysipelas or bacterial cellulitis. Read More

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December 2018
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Disease-specific characteristics of vascular cell adhesion molecule-1 levels in patients with peripheral artery disease.

Heart Vessels 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine I, Friedrich Schiller University Jena, Jena, Germany.

Peripheral arterial disease (PAD) is one of the most common manifestations of systemic atherosclerosis. The prevalence of unrecognized PAD is high, leading to a lack of opportunity to detect subjects at a high risk for cardiovascular events. Inflammatory processes play an important role in the disease initiation as well as in the disease progression. Read More

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December 2018
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To what extend is nail ultrasound discriminative between psoriasis, psoriatic arthritis and healthy subjects?

Rheumatol Int 2018 Dec 10. Epub 2018 Dec 10.

Department of Social Psychology and Methodology, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, Spain.

To assess the discriminative utility of nail features detected by B-mode (BM) and color Doppler (CD) ultrasound (US) between patients with psoriasis (PsO) and psoriatic arthritis (PsA) and healthy controls. Sixty patients with PsA, 21 patients with PsO, and 20 healthy controls were prospectively included. All patients underwent a dermatologic assessment and PsA patients also a rheumatologic assessment. Read More

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December 2018

Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions.

Eur Radiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75022, USA.

Peripheral nerve sheath tumors (PNSTs) account for ~ 5% of soft tissue neoplasms and are responsible for a wide spectrum of morbidities ranging from localized neuropathy to fulminant metastatic spread and death. MR imaging represents the gold standard for identification of these neoplasms, however, current anatomic MR imaging markers do not reliably detect or differentiate benign and malignant lesions, and therefore, biopsy or excision is required for definitive diagnosis. Diffusion-weighted MR imaging (DWI) serves as a useful tool in the evaluation and management of PNSTs by providing functional information regarding the degree of diffusion, while diffusion tensor imaging (DTI) aids in determining the directional information of predominant diffusion and has been shown to be particularly useful for pre-operative planning of these tumors by delineating healthy and pathologic fascicles. Read More

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December 2018