290 results match your criteria Dermatology and Therapy [Journal]


Tolerability of Topical Treatments for Atopic Dermatitis.

Dermatol Ther (Heidelb) 2019 Jan 24. Epub 2019 Jan 24.

Pfizer Inc., San Francisco, CA, USA.

Atopic dermatitis (AD) is a common inflammatory skin disease that is accompanied by increased sensitivity to itch-provoking and pain-provoking stimuli. Patients with AD experience skin pain before initiation of therapy and have also reported painful application site reactions in clinical trials of emollients and prescription topical therapies, including topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and a topical phosphodiesterase 4 (PDE4) inhibitor. To compare the sensory tolerability of prescription topical therapies for AD, a comprehensive literature search and analysis of published clinical trials was conducted. Read More

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http://dx.doi.org/10.1007/s13555-019-0280-7DOI Listing
January 2019

New Vision in Photoprotection and Photorepair.

Dermatol Ther (Heidelb) 2019 Jan 23. Epub 2019 Jan 23.

Policlinique de Dermatologie, Hôpital Saint Louis, Paris, France.

Chronic exposure to solar radiation is associated with an increased incidence of skin cancer worldwide and more specifically with non-melanoma skin cancers and actinic keratosis. At the cellular level DNA damage is the main event following ultraviolet (UV) exposure. The kind of lesions produced depends on the wavelength and the energy profile of the radiation, with different photoproducts being formed as a result. Read More

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http://dx.doi.org/10.1007/s13555-019-0282-5DOI Listing
January 2019
2 Reads

Self-Assessments of Standardized Scalp Massages for Androgenic Alopecia: Survey Results.

Dermatol Ther (Heidelb) 2019 Jan 22. Epub 2019 Jan 22.

Department of Civil and Environmental Engineering, University of California at Berkeley, Berkeley, CA, USA.

Introduction: Standardized scalp massages (SSMs) improve hair thickness in nonbalding men, but their effects on androgenic alopecia (AGA) have not yet been evaluated. The objective of this study was to investigate the effect of SSMs on self-assessed AGA sufferers (SAGASs).

Methods: Between October 2016 and October 2017, 1899 SAGASs searching online for hair loss treatments beyond AGA management drugs accessed literature explaining SSMs as a potential therapy for AGA, then watched a demonstration video detailing twice-daily, 20-min SSMs segmented by three rotational scalp regions using hand-generated presses, pinches, and stretches. Read More

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http://dx.doi.org/10.1007/s13555-019-0281-6DOI Listing
January 2019
4 Reads

Clinical Goals and Barriers to Effective Psoriasis Care.

Dermatol Ther (Heidelb) 2018 Dec 21. Epub 2018 Dec 21.

Harvard Medical Faculty Physicians, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Engaging global key opinion leaders, the International Psoriasis Council (IPC) held a day-long roundtable discussion with the primary purpose to discuss the treatment goals of psoriasis patients and worldwide barriers to optimal care. Setting clear expectations might ultimately encourage undertreated psoriasis patients to seek care in an era in which great gains in therapeutic efficacy have been achieved. Here, we discuss the option for early treatment of all categories of psoriasis to alleviate disease impact while emphasizing the need for more focused attention for psoriasis patients with mild and moderate forms of this autoimmune disease. Read More

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http://link.springer.com/10.1007/s13555-018-0279-5
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http://dx.doi.org/10.1007/s13555-018-0279-5DOI Listing
December 2018
7 Reads

The Role of Vitamins and Minerals in Hair Loss: A Review.

Dermatol Ther (Heidelb) 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.

People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Read More

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http://link.springer.com/10.1007/s13555-018-0278-6
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http://dx.doi.org/10.1007/s13555-018-0278-6DOI Listing
December 2018
24 Reads

Propionibacterium (Cutibacterium) acnes Bacteriophage Therapy in Acne: Current Evidence and Future Perspectives.

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. Read More

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http://dx.doi.org/10.1007/s13555-018-0275-9DOI Listing
December 2018
3 Reads

Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence.

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Plastic Surgery, Tan Tock Seng Hospital, Singapore, Republic of Singapore.

Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. Read More

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http://dx.doi.org/10.1007/s13555-018-0277-7DOI Listing
December 2018
2 Reads

Clinical and Biophysical Outcomes of Combining Microfocused Ultrasound with Visualization and Calcium Hydroxylapatite Filler for Facial Treatment.

Dermatol Ther (Heidelb) 2018 Dec 8. Epub 2018 Dec 8.

Merz Pharmaceuticals, Frankfurt, Germany.

Introduction: Combined cosmetic treatments are becoming increasingly popular. The objective of this clinical evaluation was to assess the long-term safety and efficacy of combining microfocused ultrasound with visualization (MFU-V) treatment with a calcium hydroxylapatite (CaHA) dermal filler to tighten skin at the submental region and contour the jawline.

Methods: Women with loss of contour and skin laxity in the lower face received MFU-V treatment. Read More

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http://dx.doi.org/10.1007/s13555-018-0273-yDOI Listing
December 2018
9 Reads

Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis.

Dermatol Ther (Heidelb) 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Introduction: Erysipelas and bacterial cellulitis are two of the most common infectious skin diseases. They are usually caused by the β-hemolytic group of Streptococcus, and less frequently by other bacteria. The objective of the study was to assess the factors affecting the length of stay of patients admitted to hospital with erysipelas or bacterial cellulitis. Read More

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http://dx.doi.org/10.1007/s13555-018-0276-8DOI Listing
December 2018
3 Reads

Efficacy and Safety of a Water-Based Head Lice Lotion: A Randomized, Controlled, Investigator-Blinded, Comparative, Bicentric Study.

Dermatol Ther (Heidelb) 2018 Nov 30. Epub 2018 Nov 30.

Adriaens Consulting, Bellemdorpweg 95, 9881, Bellem, Oost-Vlaanderen, Belgium.

Introduction: Silicones (e.g., dimethicone) are effective and safe alternatives to insecticides for the treatment of head lice. Read More

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http://dx.doi.org/10.1007/s13555-018-0274-xDOI Listing
November 2018
3 Reads

A Case Report of Scrotal Rejuvenation: Laser Treatment of Angiokeratomas of the Scrotum.

Authors:
Philip R Cohen

Dermatol Ther (Heidelb) 2018 Nov 26. Epub 2018 Nov 26.

San Diego Family Dermatology, National City, CA, USA.

Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Read More

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http://link.springer.com/10.1007/s13555-018-0272-z
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http://dx.doi.org/10.1007/s13555-018-0272-zDOI Listing
November 2018
6 Reads

Impact of Ixekizumab Treatment on Itch and Psoriasis Area and Severity Index in Patients with Moderate-to-Severe Plaque Psoriasis: An Integrated Analysis of Two Phase III Randomized Studies.

Dermatol Ther (Heidelb) 2018 Dec 21;8(4):621-637. Epub 2018 Nov 21.

Department of Dermatology, University of Muenster, Muenster, Germany.

Introduction: We evaluated baseline itch and its impact on the efficacy of ixekizumab (IXE) in clearing psoriasis and improving quality-of-life measures, and we explored the relationship between itch and psoriatic skin improvement.

Methods: Data were analyzed from two double-blind, randomized, controlled phase III studies (UNCOVER-2/3) comparing etanercept (ETN), IXE, and placebo (PBO) in patients with moderate-to-severe plaque psoriasis. Long-term analysis included UNCOVER-3 data from week 0 to week 156. Read More

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http://dx.doi.org/10.1007/s13555-018-0267-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261114PMC
December 2018
7 Reads

Burden of Herpes Zoster in the Japanese Population with Immunocompromised/Chronic Disease Conditions: Results from a Cohort Study Claims Database from 2005-2014.

Dermatol Ther (Heidelb) 2018 Nov 19. Epub 2018 Nov 19.

Healthoutcomes Department, GSK, Tokyo, Japan.

Introduction: The aim of this study is to describe the disease burden and costs of herpes zoster (HZ) in the general adult Japanese population or patients with immunocompromised (IC) conditions or chronic disorders.

Methods: A retrospective cohort study of individuals aged 18-74 years was conducted using January 2005 to December 2014 records from the Japan Medical Data Center claims database. Twenty-eight IC conditions and chronic disorders were defined by diagnosis codes and/or procedures/treatments. Read More

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http://dx.doi.org/10.1007/s13555-018-0268-8DOI Listing
November 2018
5 Reads

A Simulation-Based Workshop to Improve Dermatologists' Communication Skills: A Pilot for Continuing Medical Education.

Dermatol Ther (Heidelb) 2018 Nov 17. Epub 2018 Nov 17.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Introduction: Communication skills influence the quality of health care and patient experience; both may affect provider reimbursement. There are few opportunities available for practicing physicians to receive direct feedback on communication in patient encounters. The purpose of this simulation-based patient encounter workshop was for dermatologists to practice and obtain feedback on their communication skills. Read More

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http://dx.doi.org/10.1007/s13555-018-0270-1DOI Listing
November 2018
10 Reads

A Case of Acute Pemphigus Vulgaris Relapses Associated with Cocaine Use and Review of the Literature.

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):653-663. Epub 2018 Nov 10.

Department of Neurology, Alzheimer Research Center Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Pemphigus is a bullous autoimmune disease that affects the skin and mucous membranes. It is very difficult to establish the etiology and the triggering factors that influence reactivations in pemphigus vulgaris (PV). The case of a 33-year-old male with chronic history of intranasal cocaine consumption is presented in this report. Read More

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https://www.researchgate.net/publication/242652021_Pemphigus
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http://link.springer.com/10.1007/s13555-018-0271-0
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http://dx.doi.org/10.1007/s13555-018-0271-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261113PMC
December 2018
15 Reads

Scoping Review on Use of Drugs Targeting Interleukin 1 Pathway in DIRA and DITRA.

Dermatol Ther (Heidelb) 2018 Dec 3;8(4):539-556. Epub 2018 Nov 3.

Immune-Mediated Inflammatory Skin Disease Research Group, IMIBIC/Reina Sofía University Hospital/University of Córdoba, Avenida Menéndez Pidal, Córdoba, 14004, Spain.

Introduction: Deficiencies in interleukin (IL)-1 receptor (IL-R) antagonist (DIRA) and IL-36R antagonist (DITRA) are rare genetic autoinflammatory diseases related to alterations in antagonists of the IL-1 pathway. IL-1 antagonists may represent therapeutic alternatives. Here, we aim to provide a scoping review of knowledge on use of IL-1-targeting drugs in DIRA and DITRA. Read More

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http://link.springer.com/10.1007/s13555-018-0269-7
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http://dx.doi.org/10.1007/s13555-018-0269-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261121PMC
December 2018
12 Reads

Crisaborole Ointment Improves Quality of Life of Patients with Mild to Moderate Atopic Dermatitis and Their Families.

Dermatol Ther (Heidelb) 2018 Dec 22;8(4):605-619. Epub 2018 Oct 22.

Anacor Pharmaceuticals, Inc., a wholly owned subsidiary of Pfizer Inc., New York, NY, USA.

Introduction: The impact of crisaborole ointment, a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild to moderate atopic dermatitis (AD), on quality of life (QoL) was assessed in two identically designed phase 3 studies (AD-301: NCT02118766; AD-302: NCT02118792, both at http://www.clinicaltrials.gov ). Read More

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http://link.springer.com/10.1007/s13555-018-0263-0
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http://dx.doi.org/10.1007/s13555-018-0263-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261115PMC
December 2018
9 Reads

Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis.

Dermatol Ther (Heidelb) 2018 Dec 20;8(4):593-604. Epub 2018 Oct 20.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Introduction: Psoriatic arthritis (PsA) is a chronic, inflammatory arthritis that affects an estimated 30% of patients with psoriasis. PsA is underdiagnosed in primary care and dermatology clinics due to a variety of reasons, including failure of healthcare providers to ask about symptoms, overlap of symptoms and signs with other rheumatologic conditions, and lack of a specific diagnostic test. A delay in PsA diagnosis and treatment, even as short as 6 months, can lead to decreased quality of life, increased joint damage, and worse long-term physical function. Read More

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http://link.springer.com/10.1007/s13555-018-0266-x
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http://dx.doi.org/10.1007/s13555-018-0266-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261122PMC
December 2018
11 Reads

Secukinumab is Superior to Ustekinumab in Clearing Skin in Patients with Moderate to Severe Plaque Psoriasis (16-Week CLARITY Results).

Dermatol Ther (Heidelb) 2018 Dec 17;8(4):571-579. Epub 2018 Oct 17.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, has demonstrated superior efficacy to ustekinumab in the phase 3b CLEAR study of moderate to severe plaque psoriasis. Here, we report 16-week results from CLARITY, a second head-to-head trial comparing secukinumab with ustekinumab.

Methods: In the phase 3b CLARITY study, patients were randomized 1:1 to receive subcutaneous secukinumab 300 mg or ustekinumab per label. Read More

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http://link.springer.com/10.1007/s13555-018-0265-y
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http://dx.doi.org/10.1007/s13555-018-0265-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261116PMC
December 2018
10 Reads

The Comorbidity Burden of Hidradenitis Suppurativa in the United States: A Claims Data Analysis.

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):557-569. Epub 2018 Oct 10.

Global Health Economics and Outcomes Research, AbbVie Inc, North Chicago, IL, USA.

Introduction: Prior studies have reported that hidradenitis suppurativa (HS) is accompanied by a myriad of physical and mental conditions. However, given the small sample sizes and the limited number of pre-selected comorbidities, these studies do not provide a complete picture of the comorbidity burden of HS in the USA. Moreover, the relationship between HS severity and comorbidity burden has yet to be characterized. Read More

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http://link.springer.com/10.1007/s13555-018-0264-z
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http://dx.doi.org/10.1007/s13555-018-0264-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261111PMC
December 2018
13 Reads

A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate.

Dermatol Ther (Heidelb) 2018 Dec 25;8(4):647-651. Epub 2018 Sep 25.

Department of Dermatology, Farhat Hached University Hospital, Sousse, Tunisia.

Psoriasis is a chronic inflammatory disease affecting the skin, nails, and joints. About 61% of psoriatic patients have nail involvement that can cause a significant social problem. Treating nail psoriasis is challenging but can improve the health outcomes and quality of life of patients. Read More

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http://dx.doi.org/10.1007/s13555-018-0261-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261120PMC
December 2018
1 Read

Disease Burden and Treatment Patterns of Psoriasis in Russia: A Real-World Patient and Dermatologist Survey.

Dermatol Ther (Heidelb) 2018 Dec 19;8(4):581-592. Epub 2018 Sep 19.

Data Pyxis Ltd., St Albans, UK.

Introduction: Data regarding disease burden and quality of life (QoL) for patients with psoriasis from Russia are limited. The objective of this study was to describe the demographic and clinical characteristics, comorbidities, and treatment patterns of systemic therapy eligible psoriasis patients in Russia in order to assess the impact of psoriasis on the QoL and work productivity of the patients and to evaluate patient/dermatologist concordance on disease severity, signs/symptoms, and satisfaction with psoriasis treatment.

Methods: Data were collected by the Growth from Knowledge Disease Atlas global real-world evidence programme from nine countries. Read More

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http://dx.doi.org/10.1007/s13555-018-0262-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261112PMC
December 2018
1 Read

Acral Melanoma: A Patient's Experience and Physician's Commentary.

Dermatol Ther (Heidelb) 2018 Dec 18;8(4):503-507. Epub 2018 Sep 18.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, USA.

This article, co-authored by a patient diagnosed with acral melanoma, discusses the patient's experience of being diagnosed with and treated with surgery for this disease. The physician discusses the epidemiology, genetics, diagnosis, treatment, and prognosis of acral melanoma. Follow-up care plans are also discussed. Read More

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http://dx.doi.org/10.1007/s13555-018-0260-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261119PMC
December 2018
1 Read

Topical Selenium Sulfide for the Treatment of Hyperkeratosis.

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):639-646. Epub 2018 Sep 10.

University of California San Diego Hyperbaric Medicine and Wound Healing Center, Encinitas, CA, USA.

Hyperkeratosis presents as thickened skin. It can be congenital or acquired. Typically, it affects the palms and soles; the distribution of epidermal involvement is either diffuse, focal, or punctate. Read More

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http://link.springer.com/10.1007/s13555-018-0259-9
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http://dx.doi.org/10.1007/s13555-018-0259-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261123PMC
December 2018
8 Reads

Treatment of Atopic Dermatitis with Biologic Drugs.

Dermatol Ther (Heidelb) 2018 Dec 4;8(4):527-538. Epub 2018 Sep 4.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin disease which predominately affects children and usually clears up during infancy or childhood. However, AD may persist with a chronic relapsing course until adulthood or develop at a later age. AD treatment can often be complicated. Read More

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http://dx.doi.org/10.1007/s13555-018-0258-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261117PMC
December 2018
15 Reads

Treatment of Genital Psoriasis: A Systematic Review.

Dermatol Ther (Heidelb) 2018 Dec 25;8(4):509-525. Epub 2018 Aug 25.

Department of Dermatology, UCSF Medical Center, San Francisco, CA, USA.

Genital psoriasis affects approximately 63% of psoriasis patients at least once in their lifetime. More than any other area on the body, genital lesions significantly impair patients' psychologic well-being and quality of life. We aimed to systematically review the published evidence on the safety, efficacy, and tolerability of treatments of genital psoriasis and synthesize the available clinical data. Read More

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http://dx.doi.org/10.1007/s13555-018-0257-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261118PMC
December 2018
15 Reads

Trichotillomania and Trichophagia: Modern Diagnostic and Therapeutic Methods.

Dermatol Ther (Heidelb) 2018 Sep 11;8(3):389-398. Epub 2018 Aug 11.

Department of Dermatology, University of Rzeszów, Rzeszów, Poland.

Trichotillomania is a chronic, mental disease of impulse control, characterized by repetitive, compulsive, and self-induced hair pulling. It can occur at any age but is observed more often in adolescents, with a strong predominance in females. Diagnosis of trichotillomania may be difficult, and its effective treatment challenging. Read More

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http://dx.doi.org/10.1007/s13555-018-0256-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109030PMC
September 2018
1 Read

A Rapid and Cost-Effective Device for Testing Minimal Erythema Dose.

Dermatol Ther (Heidelb) 2018 Sep 10;8(3):483-489. Epub 2018 Aug 10.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Introduction: We describe a novel device for rapid and economical minimal erythema dose testing in patients undergoing ultraviolet (UV) light phototherapy for treatment of skin diseases.

Methods: A minimal erythema testing device was designed and created using transparent plastic sheeting and printed patterns with increasing ink density, allowing for graded UV transmission of 100%, 80%, 60%, 40%, 20%, and 10% energy through six 10-mm square apertures. The plastic sheet was placed in a UV-impenetrable and Velcro-fitted adjustable sleeve, designed to fit easily onto a patient's arm. Read More

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http://dx.doi.org/10.1007/s13555-018-0255-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109034PMC
September 2018
1 Read

A Single-Arm, Open-Label, Phase IV Study to Evaluate the Efficacy of a Topical Formulation for Hyperkeratotic Actinic Keratosis Lesions.

Dermatol Ther (Heidelb) 2018 Sep 27;8(3):455-462. Epub 2018 Jul 27.

International Hair Research Foundation (IHRF), Milan, Italy.

Introduction: Actinic keratosis (AKs) are epidermal lesions that commonly occur in skin exposed to chronic cumulative UV irradiation. Untreated AK lesions can advance to squamous cell carcinoma. Current treatments of AK have many shortcomings; for instance, not all treatments can be used for the hyperkeratotic form of AK. Read More

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http://dx.doi.org/10.1007/s13555-018-0252-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109024PMC
September 2018
1 Read

Daily Application of an Aqueous, Acidifying, Peelable Nail Polish versus Weekly Amorolfine for Topical Onychomycosis Treatment: A Prospective, Randomized, Blinded Trial.

Dermatol Ther (Heidelb) 2018 Sep 26;8(3):463-473. Epub 2018 Jul 26.

Adriaens Consulting, Bellemdorpweg 95, 9881, Bellem, OVL, Belgium.

Introduction: Onychomycosis is a fungal nail infection, frequently caused by dermatophytes, which occurs in 2-14% of Western adults. The present study was set up to evaluate the efficacy and safety of a water-based, peelable nail polish (daily application), which acidifies the nail environment, versus a 5% amorolfine nail lacquer (weekly application) for topical treatment of mild-to-moderate onychomycosis.

Methods: One hundred two adults were randomized in this open, prospective, blinded trial. Read More

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http://dx.doi.org/10.1007/s13555-018-0254-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109032PMC
September 2018
1 Read

Topical Application of 5-Fluorouracil Associated with Distant Seborrheic Dermatitis-like Eruption: Case Report and Review of Seborrheic Dermatitis Cutaneous Reactions after Systemic or Topical Treatment with 5-Fluorouracil.

Dermatol Ther (Heidelb) 2018 Sep 26;8(3):495-501. Epub 2018 Jul 26.

Department of Dermatology, University of California San Diego, La Jolla, CA, USA.

Introduction: 5-Fluorouracil is a fluoropyrimidine antineoplastic medication that is used to topically treat actinic keratoses. Although local adverse effects to the drug are common and anticipated, distant skin reactions are rare and unexpected. In this case report, we describe a patient who developed seborrheic dermatitis-like eruption at a distant site after topical application of 5-fluorouracil to his arms. Read More

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http://dx.doi.org/10.1007/s13555-018-0253-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109033PMC
September 2018
4 Reads

Effect of Prior Biologic Use on Cost-Effectiveness of Brodalumab vs. Ustekinumab for Treatment of Moderate-to-Severe Psoriasis in the United States.

Dermatol Ther (Heidelb) 2018 Sep 13;8(3):441-453. Epub 2018 Jul 13.

Novosys Health, Green Brook, NJ, USA.

Introduction: Clinical trials have shown brodalumab to have better efficacy than ustekinumab for the treatment of moderate-to-severe psoriasis. An estimation of the cost-effectiveness of brodalumab vs. ustekinumab is warranted and may be useful for treatment decision-making processes, especially in the context of the cost considerations of the current US healthcare system. Read More

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http://dx.doi.org/10.1007/s13555-018-0251-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109035PMC
September 2018
3 Reads

Patient Reported Improvement After Patch Testing and Allergen Avoidance Counseling: A Retrospective Analysis.

Dermatol Ther (Heidelb) 2018 Sep 9;8(3):435-440. Epub 2018 Jul 9.

Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.

Introduction: Our objectives were to assess patient-reported improvement after patch testing at the 2-3-month follow-up visit in patients referred for patch testing with relevant positive patch test reactions at the University of California, San Francisco.

Methods: Cross-sectional analyses of patients patch tested between 2013 and 2016 who returned for a follow-up visit approximately 2-3 months after patch testing. We examined positive patch test results considered of definite, probable or possible relevance to the patient's eczematous eruptions. Read More

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http://dx.doi.org/10.1007/s13555-018-0250-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109020PMC
September 2018
2 Reads

Topical Ivermectin in the Treatment of Papulopustular Rosacea: A Systematic Review of Evidence and Clinical Guideline Recommendations.

Dermatol Ther (Heidelb) 2018 Sep 25;8(3):379-387. Epub 2018 Jun 25.

Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands.

Introduction: Rosacea is a chronic inflammatory skin disease with different phenotypes. There is accumulating evidence that the commensal Demodex mite is linked to papulopustular rosacea. Established treatment options, including topical metronidazole, azelaic acid, and tetracyclines, are thought to work through their anti-inflammatory effects. Read More

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http://dx.doi.org/10.1007/s13555-018-0249-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109029PMC
September 2018
30 Reads

Efficacy Endpoints in Clinical Trials in Actinic Keratosis.

Dermatol Ther (Heidelb) 2018 Sep 18;8(3):425-433. Epub 2018 Jun 18.

Department of Dermatology, University of Miami Miller School of Medicine, Miami, USA.

Introduction: Actinic keratosis is regarded as a chronic disease of the skin and, although fluctuating, is chronically progressive. Approval of new products for the treatment of actinic keratosis requires the use of a standard methodology in clinical trials which emphasize complete clearance of all actinic keratoses in a treatment field in a defined time span and the evaluation of long-term efficacy in terms of recurrence rate among completely cleared patients.

Methods: Analysis of data from six previously published clinical trials in patients with actinic keratosis. Read More

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http://dx.doi.org/10.1007/s13555-018-0247-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109027PMC
September 2018
1 Read

Development of Low-Cost Locally Sourced Two-Component Compression Bandages in Western Kenya.

Dermatol Ther (Heidelb) 2018 Sep 15;8(3):475-481. Epub 2018 Jun 15.

Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.

Introduction: Compression therapy is well-established standard of care for chronic leg ulcers from venous disease and lymphedema. Chronic leg ulcers and lymphedema have a significant impact on quality of life, driven by pain, foul odor, and restricted mobility. Provision of layered compression therapy in resource-limited settings, as in Western Kenya and other regions of sub-Saharan Africa, is a major challenge due to several barriers: availability, affordability, and access to healthcare facilities. Read More

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http://dx.doi.org/10.1007/s13555-018-0248-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109023PMC
September 2018
22 Reads

Building a Citizen Pscientist: Advancing Patient-Centered Psoriasis Research by Empowering Patients as Contributors and Analysts.

Dermatol Ther (Heidelb) 2018 Sep 6;8(3):405-423. Epub 2018 Jun 6.

Department of Dermatology, University of California San Francisco, San Francisco, USA.

Introduction: To design and implement a novel cloud-based digital platform that allows psoriatic patients and researchers to engage in the research process.

Methods: Citizen Pscientist (CP) was created by the National Psoriasis Foundation (NPF) to support and educate the global psoriatic disease community, where patients and researchers have the ability to analyze data. Psoriatic patients were invited to enroll in CP and contribute health data to a cloud database by responding to a 59-question online survey. Read More

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http://link.springer.com/10.1007/s13555-018-0242-5
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http://dx.doi.org/10.1007/s13555-018-0242-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109031PMC
September 2018
13 Reads

Basal Cell Carcinoma: A Patient and Physician's Experience.

Dermatol Ther (Heidelb) 2018 Sep 2;8(3):329-337. Epub 2018 Jun 2.

Department of Dermatology, University of California San Diego, La Jolla, San Diego, CA, USA.

In this article, the first coauthor, a patient with a basal cell carcinoma on her upper lip, discusses her experience with Mohs micrographic surgery for the treatment of the skin cancer. The second coauthor, who is the patient's physician (a dermatologist who shares her last name but is not a relative), diagnosed her skin cancer and referred her for Mohs surgery. The third coauthor, who is the patient's son and not only a dermatologist, but also a dermatopathologist and a Mohs surgeon (and also shares her last name), summarizes the presentation and treatment of the basal cell carcinoma. Read More

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http://dx.doi.org/10.1007/s13555-018-0245-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109021PMC
September 2018
3 Reads

A Systematic Scoping Literature Review of Publications Supporting Treatment Guidelines for Pediatric Atopic Dermatitis in Contrast to Clinical Practice Patterns.

Dermatol Ther (Heidelb) 2018 Sep 1;8(3):349-377. Epub 2018 Jun 1.

Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.

Introduction: Treatment guidelines endorse a variety of strategies for atopic dermatitis (AD) which may vary from published data and clinical practice patterns. The objective of this review was to quantify the volume of available medical literature supporting pediatric AD treatments and compare these patterns to those recommended by published guidelines and/or clinical practice patterns.

Methods: Searches of Embase (2005-2016) and abstracts from selected meetings (2014-2016) related to AD treatment in patients younger than 17 years of age yielded references that were assessed by study design, primary treatment, age groups, and AD severity. Read More

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http://dx.doi.org/10.1007/s13555-018-0243-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109028PMC
September 2018
34 Reads

Treatment of Grade II and III Actinic Keratosis Lesions with a Film-Forming Medical Device Containing Sunscreen/Piroxicam 0.8% and a Retinoic Acid/Glycolic Gel: A Pilot Trial.

Dermatol Ther (Heidelb) 2018 Sep 31;8(3):399-404. Epub 2018 May 31.

Dermatology Division, Sassuolo Hospital, Sassuolo, Italy.

Introduction: Lesion and field-targeted treatments of actinic keratosis (AK) are commonly indicated for grade I and II type lesions. Grade III lesions are in general more difficult to treat. A film-forming medical device containing piroxicam 0. Read More

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http://dx.doi.org/10.1007/s13555-018-0244-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109025PMC
September 2018
5 Reads

Squamous Cell Carcinomas in Two Cases of Nail Lichen Planus: Is There a Real Association?

Dermatol Ther (Heidelb) 2018 Sep 31;8(3):491-494. Epub 2018 May 31.

Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Naples, Italy.

Lichen planus (LP) is a chronic inflammatory disease that affects the skin and oral mucosa. Although its etiology is unknown, its potential for cancerization has been confirmed. We herein report the cases of a brother and sister, both with a 15-year history of nail lichen planus of the fingers and toes, who developed squamous cell carcinomas of the nail bed and matrix. Read More

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http://dx.doi.org/10.1007/s13555-018-0246-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109022PMC
September 2018
1 Read

Beneficial Effects of Antioxidant Furfuryl Palmitate in Non-pharmacologic Treatments (Prescription Emollient Devices, PEDs) for Atopic Dermatitis and Related Skin Disorders.

Dermatol Ther (Heidelb) 2018 Sep 22;8(3):339-347. Epub 2018 May 22.

Dipartimento di Scienze biomediche, chirurgiche e odontoiatriche, Clinica Dermatologica, Università degli Studi di Milano, Milan, Italy.

Introduction: Atopic dermatitis (AD) is a common chronic inflammatory skin disease; it requires long-term treatments focused on symptomatic relief. Current first-line treatments include moisturizers and topical corticosteroids. Recently, topical antioxidants have been added to moisturizer formulations to alleviate mild-to-moderate AD. Read More

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http://dx.doi.org/10.1007/s13555-018-0239-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109026PMC
September 2018
1 Read

Integra-Dermal Regeneration Template and Split-Thickness Skin Grafting: A Therapy Approach to Correct Aplasia Cutis Congenita and Epidermolysis Bullosa in Carmi Syndrome.

Dermatol Ther (Heidelb) 2018 Jun 18;8(2):313-321. Epub 2018 May 18.

Department and Clinic of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

The association of junctional epidermolysis bullosa with pyloric atresia (JEB-PA) and aplasia cutis congenita (ACC) was described by El Shafie et al. (J Pediatr Surg 14(4):446-449, 1979) and Carmi et al. (Am J Med Genet 11:319-328, 1982). Read More

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http://dx.doi.org/10.1007/s13555-018-0237-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002319PMC
June 2018
6 Reads

Omalizumab in Chronic Spontaneous Urticaria Refractory to Conventional Therapy: An Italian Retrospective Clinical Analysis with Suggestions for Long-Term Maintenance Strategies.

Dermatol Ther (Heidelb) 2018 Jun 16;8(2):291-301. Epub 2018 May 16.

Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Introduction: Omalizumab is indicated for the treatment of patients affected by chronic spontaneous urticaria (CSU) refractory to antihistamines. The aim of this study was to assess the efficacy, safety, and recurrence of symptoms in a real-life experience of omalizumab as an add-on therapy for H-antihistamine-refractory CSU patients (refractory CSU).

Methods: A retrospective review of the clinical records of all refractory CSU treated with omalizumab at our dermatology center from June 2014 to April 2017 was performed. Read More

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http://dx.doi.org/10.1007/s13555-018-0240-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002323PMC
June 2018
3 Reads

Exploration of Patient Characteristics and Quality of Life in Patients with Lipoedema Using a Survey.

Dermatol Ther (Heidelb) 2018 Jun 10;8(2):303-311. Epub 2018 May 10.

Department of Dermatology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Introduction: Lipoedema is a chronic disorder in which excessive fat distribution occurs predominantly from the waist down, resulting in a disproportion between the lower extremities and upper torso. Lipoedema is often not recognized, while patients experience pain and easy bruising. As a long-term condition, lipoedema has a massive effect on patients' lives and mental health. Read More

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http://dx.doi.org/10.1007/s13555-018-0241-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002318PMC
June 2018
2 Reads

Effect of Topical Steroids on Skin Prick Test: A Randomized Controlled Trial.

Dermatol Ther (Heidelb) 2018 Jun 4;8(2):285-290. Epub 2018 May 4.

Department of Pediatrics, Regional Hospital Central Jutland, Viborg, Denmark.

Introduction: Topically applied corticosteroids on the skin can significantly inhibit the wheal response to allergens in skin prick test (SPT). The duration of this effect is unknown. The aim of this study is to investigate the duration of the inhibitory effect of topical corticosteroids on SPT. Read More

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http://dx.doi.org/10.1007/s13555-018-0238-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002313PMC
June 2018
1 Read

The Potential Public Health Impact of Herpes Zoster Vaccination of People Aged ≥ 50 Years in Japan: Results of a Markov Model Analysis.

Dermatol Ther (Heidelb) 2018 Jun 21;8(2):269-284. Epub 2018 Apr 21.

Faculty of Pharmaceutical Sciences, Teikyo Heisei University, 4-21-2, Nakano, Nakano-ku, Tokyo, Japan.

Introduction: The aim of this study was to compare the public health impact of introducing two herpes zoster (HZ) vaccines into the vaccination programs for the Japanese population aged ≥ 50 years: a single-dose Varicella Vaccine Live (VVL) or a two-dose adjuvanted Recombinant Zoster Vaccine (RZV).

Methods: A multi-cohort static Markov model was developed to follow age cohorts (50-59, 60-69, 70-79 and ≥ 80 years) over their remaining lifetime. Japan-specific data inputs for the model were obtained from Japanese data sources. Read More

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http://dx.doi.org/10.1007/s13555-018-0236-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002317PMC
June 2018
6 Reads

A Scoping Review Protocol to Explore the Use of Interleukin-1-Targeting Drugs for the Treatment of Dermatological Diseases: Indications, Mechanism of Action, Efficacy, and Safety.

Dermatol Ther (Heidelb) 2018 Jun 6;8(2):195-202. Epub 2018 Apr 6.

Department of Dermatology, Hospital Universitario Reina Sofía, Córdoba, Spain.

Introduction: The interleukin (IL)-1 pathway has been identified as being involved in inflammatory and neoplastic skin diseases such as psoriasis, atopic dermatitis, neutrophilic dermatosis, melanoma, and squamous cell carcinoma. Drugs developed to target the IL-1 pathway are currently used to treat these pathologies, and although they are becoming more selective, they are not exempt from adverse events and high costs. Integrating the best research evidence with clinical experience and patient needs has been shown to improve care, health, and cost outcomes. Read More

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http://dx.doi.org/10.1007/s13555-018-0235-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002324PMC
June 2018
2 Reads

Drug Treatment for Androgenetic Alopecia: First Italian Questionnaire Survey on What Dermatologists Think about Finasteride.

Dermatol Ther (Heidelb) 2018 Jun 24;8(2):259-267. Epub 2018 Mar 24.

International Hair Research Foundation (IHRF), Milan, Italy.

Introduction: Treatment with finasteride 1 mg/day represents the therapy of choice for androgenetic alopecia (AGA). We investigated how Italian dermatologists approach use of finasteride for treatment of AGA and common side effects reported by patients.

Methods: A tablet-based survey was conducted from February 2017 to January 2018 in Italy to investigating use of 1 mg/day finasteride in the treatment of AGA. Read More

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http://dx.doi.org/10.1007/s13555-018-0233-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002321PMC
June 2018
11 Reads

Author Correction: Secukinumab Demonstrates Significantly Lower Immunogenicity Potential Compared to Ixekizumab.

Dermatol Ther (Heidelb) 2018 Jun;8(2):327

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.

In the original publication, information regarding "ustekinumab" was incorrectly published under the Methods section. The correct information in the section "Antibodies and Control Protein" should be "(secukinumab, 150 mg/mL; ixekizumab, 90 mg/mL; adalimumab, 50 mg/mL; ustekinumab 90 mg/ml)". Infliximab, which is mentioned in that section, was not used in the study. Read More

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http://dx.doi.org/10.1007/s13555-018-0234-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002311PMC
June 2018
44 Reads