204,939 results match your criteria Dermatology Times[Journal]


Insight into Imiquimod Skin Permeation and Increased Delivery Using Microneedle Pre-treatment.

Eur J Pharm Biopharm 2019 Feb 13. Epub 2019 Feb 13.

Division of Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham, NG7 2RD, UK. Electronic address:

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only licensed by the FDA for superficial BCC. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.006DOI Listing
February 2019

Live remote control of an in vivo reflectance confocal microscope allows diagnosis of basal cell carcinoma at the bedside on a patient 2,500 miles away: A novel tele-RCM approach.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.02.016DOI Listing
February 2019

Surgical Pearl: Use of a Gasket for Finger Tourniquet.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Gulhane Research and Training Hospital, Department of Dermatology and Venereology, 06010, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.jaad.2019.02.015DOI Listing
February 2019

Drugs used for neurological and psychiatric conditions increase the risk of bullous pemphigoid: a case-control study.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

PEDEGO Research Unit, University of Oulu; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1016/j.jaad.2019.02.017DOI Listing
February 2019

Improving Non-attendance Rates Among Pediatric Patients with Medicaid or Private Insurance.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Saint Louis University Center for Outcomes Research.

Background: Access to dermatologists by Medicaid-insured patients is low. Higher clinic non-attendance (NA) among Medicaid-insured patients may impact provider decisions to accept these patients.

Objectives: To determine the effect of different scheduling policies on the NA among children seen at a pediatric dermatology clinic. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.018DOI Listing
February 2019

Successful Utilization of Optical Coherence Tomography as a Non-Invasive, Bedside Imaging Technique To Identify Residual Nodular Basal Cell Carcinoma at Well-Healed and Clinically Unidentifiable Biopsy Site.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Laser & Skin Surgery Center of New York, New York, NY; The Ronald O. Perelman Department of Dermatology, New York University, New York, NY.

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http://dx.doi.org/10.1016/j.jaad.2019.02.012DOI Listing
February 2019

Sun Exposure Risks in Recipients of Solid Organ and Bone Marrow Transplant Athletes.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Photobiological Dermatology Laboratory. Medical Research Center. Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga. Spain; Dermatology Service. Hospital Clínico Universitario Virgen de la Victoria. Málaga. Spain.

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http://dx.doi.org/10.1016/j.jaad.2019.02.013DOI Listing
February 2019

Keratoacanthomas: A Review of Excised Specimens.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Assistant Professor, Saint Louis University Department of Dermatology, 1755 S Grand Blvd, St. Louis, MO 63104.

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http://dx.doi.org/10.1016/j.jaad.2019.02.011DOI Listing
February 2019

Identification of mineralocorticoid and glucocorticoid receptors on peripheral nociceptors: translation of experimental findings from animal to human biology.

Brain Res 2019 Feb 13. Epub 2019 Feb 13.

Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anaesthesiology and Intensive Care Medicine, Charité University Berlin, Campus Virchow Klinikum, Berlin, Germany.

Evidence is accumulating that activation of mineralocorticoid (MR) and glucocorticoid (GR) receptors on peripheral sensory neurons modulates pain sensation. While the expression and exact anatomical localization of MR and GR in the various subpopulations of peripheral sensory neurons has been shown in animals, it is still unknown for the human skin. Therefore, we aimed to identify MR and GR mRNA and protein as well as the exact subpopulations of sensory neurons in human versus rat skin. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.015DOI Listing
February 2019

Understanding Skin Screening Practices Among Children at Elevated Risk for Melanoma to Inform Interventions for Melanoma Prevention and Control.

J Cancer Educ 2019 Feb 15. Epub 2019 Feb 15.

Huntsman Cancer Institute, 2000 Circle of Hope, Rm 4509, Salt Lake City, UT, 84112, USA.

Melanoma is the deadliest form of skin cancer. Screening can aid in early disease detection, when treatment is more effective. Although there are currently no consensus guidelines regarding skin screening for pediatric populations with elevated familial risk for melanoma, at-risk children with the help of their parents and healthcare providers may implement skin self-exams. Read More

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http://dx.doi.org/10.1007/s13187-019-01489-3DOI Listing
February 2019

A Summary of 2018 and What Lies Ahead for Dermatology and Therapy in 2019.

Dermatol Ther (Heidelb) 2019 Feb 15. Epub 2019 Feb 15.

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR BRC, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s13555-019-0283-4DOI Listing
February 2019

Determinants of disease severity among patients with atopic dermatitis: association with components of the atopic march.

Arch Dermatol Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermato-venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

We aimed to explore the association of key clinical characteristics with disease severity in atopic dermatitis (AD) and its relation to components of the atopic march in a large hospital cohort. Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, between January 2012 and December 2017, were compared based on disease severity (SCORAD); mild (< 25), moderate (25-50) and severe (> 50). A total of 470 AD patients were included: 122 small children (< 4 years of age), 103 children/adolescents (age 4-15 years) and 245 adults (> 15 years of age). Read More

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http://dx.doi.org/10.1007/s00403-019-01895-zDOI Listing
February 2019

MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway.

Cell Death Dis 2019 Feb 15;10(3):148. Epub 2019 Feb 15.

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China.

Mitochondrial pyruvate carrier 1 (MPC1), a key factor that controls pyruvate transportation in the mitochondria, is known to be frequently dysregulated in tumor initiation and progression. However, the clinical relevance and potential molecular mechanisms of MPC1 in lung adenocarcinoma (LAC) progression remain to be illustrated. Herein, MPC1 was lowly expressed in LAC tissues and significantly associated with favorable survival of patients with LAC. Read More

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http://www.nature.com/articles/s41419-019-1324-8
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http://dx.doi.org/10.1038/s41419-019-1324-8DOI Listing
February 2019
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5.014 Impact Factor

Efficacy of microneedling with topical vitamin C in the treatment of melasma.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medicine, Department of Dermatology, Sohag University, Sohag University Hospital, Sohag, Egypt.

Background: Despite the wide therapeutic options available for the treatment of melasma, including many active topical medications, technologies with lights and peelings, clinical control of this disorder is extremely challenging.

Objectives: To evaluate the effect of microneedling with topical vitamin C in the treatment of melasma.

Methods: Thirty female patients with melasma received six sessions of microneedling with addition of topical vitamin C every two weeks. Read More

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http://dx.doi.org/10.1111/jocd.12878DOI Listing
February 2019

Efficacy of fractional CO laser with intralesional steroid compared with intralesional steroid alone in the treatment of keloids and hypertrophic scars.

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, K. S Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, India.

Background And Objective: Keloids and hypertrophic scars (HTS) are abnormal fibrous reactions that persist for prolonged periods, rarely regress without treatment and recur after excision. Many modalities of treatment have been advocated but the success rates of these have been variable. The present study is an attempt to evaluate and compare the efficacy of combination of fractional CO laser (FCL) and intralesional steroid (ILS) against ILS alone in the treatment of keloids and HTS. Read More

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http://dx.doi.org/10.1111/jocd.12887DOI Listing
February 2019

Nested case-control study investigating the diagnostic role of tissue eosinophilia in adverse cutaneous drug reactions.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Although tissue-eosinophilia has traditionally been considered diagnostically supportive of adverse cutaneous drug reactions (ACDRs), studies have suggested it is neither a sensitive nor a specific finding in drug eruptions (DEs).

Objectives: Determining whether skin-tissue eosinophilia is a reliable indicator of ACDR.

Methods: A nested case-control retrospective study conducted in a cohort of 170 patients at a single institution. Read More

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http://dx.doi.org/10.1111/jdv.15509DOI Listing
February 2019

Clinicians vs. epidemiologists: Patch testing with methyldibromo glutaronitrile as a controversial issue.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Information Network of Departments of Dermatology (IVDK), University Medical Center, 37073, Göttingen, Germany.

The preservative methyldibromo glutaronitrile (MDBGN) (CAS 35691-65-7) is known since long as an important contact allergen mainly used in cosmetics (Review: [1]). MDBGN was banned EU-wide from being used in leave-on products in 2005, for rinse-off products in 2008, and further restricted for non-cosmetic (technical) applications in 2010. However, positive reactions in patch testing (PT) continued to occur. Read More

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http://dx.doi.org/10.1111/jdv.15505DOI Listing
February 2019

Long-term Efficacy and Safety of Monotherapy Versus Combination Therapy in Systemic Sclerosis-associated Pulmonary Arterial Hypertension: A Retrospective Cohort Study from the Nationwide Spanish Scleroderma Registry (RESCLE).

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Autoimmune Diseases Unit. Department of Internal Medicine. Bellvitge University Hospital. L'Hospitalet de Llobregat, Barcelona, Spain; Department of Internal Medicine. Corporación Sanitaria Universitaria Parc Taulí. Sabadell, Barcelona, Spain; Unit of Autoimmune Diseases, Department of Internal Medicine. Hospital Universitario Vall d'Hebron. Barcelona, Spain; Unit of Systemic Autoimmune Diseases and Thrombosis. Department of Internal Medicine. Complejo Hospitalario Universitario de Vigo. Vigo, Pontevedra, Spain; Department of Internal Medicine. Hospital Universitario Virgen de las Nieves. Granada, Spain; Department of Internal Medicine. Hospital Universitario y Politécnico La Fe. Valencia, Spain; Department of Internal Medicine. Hospital Universitario Mútua Terrassa. Terrassa, Barcelona, Spain; Unit of Autoimmune Diseases, Department of Internal Medicine. Hospital Clínico Universitario Lozano Blesa. Zaragoza, Spain; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology. Hospital Universitario Clinic. Barcelona, Spain; Department of Internal Medicine. Hospital Universitario Central de Asturias. Oviedo, Asturias, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Hospital Campus de la Salud, Complejo Universitario de Granada. Granada, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Hospital de Cabueñes. Gijón, Asturias, Spain; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Spain; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine. Consorci Hospitalari de Vic. Vic, Barcelona, Spain; Department of Internal Medicine. Hospital Universitario Rey Juan Carlos. Móstoles, Madrid, Spain; Faculty of Medicine and Health Sciences. Universitat Internacional de Catalunya,Barcelona,Spain. Address correspondence to: Melani Pestaña-Fernández MD; Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga s/n 08907 L'Hospitalet de Llobregat Barcelona (Spain). Email:

Objective: Monotherapy is an option as first line therapy for pulmonary arterial hypertension (PAH). However, combination therapy is a beneficial alternative. Our objective was to evaluate efficacy of monotherapy vs. Read More

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http://dx.doi.org/10.3899/jrheum.180595DOI Listing
February 2019
3.187 Impact Factor

Soluble Fc-Disabled Herpes Virus Entry Mediator Augments Activation and Cytotoxicity of NK Cells by Promoting Cross-Talk between NK Cells and Monocytes.

J Immunol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH 44106;

CD160 is highly expressed by NK cells and is associated with cytolytic effector activity. Herpes virus entry mediator (HVEM) activates NK cells for cytokine production and cytolytic function via CD160. Fc-fusions are a well-established class of therapeutics, where the Fc domain provides additional biological and pharmacological properties to the fusion protein including enhanced serum and interaction with Fc receptor-expressing immune cells. Read More

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http://dx.doi.org/10.4049/jimmunol.1801449DOI Listing
February 2019

Progression of mycosis fungoides occurs through divergence of tumor immunophenotype by differential expression of HLA-DR.

Blood Adv 2019 Feb;3(4):519-530

Instititute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom; and.

Immunotherapy is a valuable treatment for many cancer patients, and there is considerable interest in understanding the mechanisms of immune evasion to guide appropriate management. Mycosis fungoides (MF) is a malignant disorder of skin-homing CD4 T cells, and it exhibits a highly variable clinical course during which the tumor-specific immune response may be an important determinant. An unusual feature of MF is that tumor-infiltrating lymphocytes (TILs) must attempt to control a malignant cell from within their own lineage. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018025114DOI Listing
February 2019

Immunomagnetic-Enriched Subpopulations of Melanoma Circulating Tumour Cells (CTCs) Exhibit Distinct Transcriptome Profiles.

Cancers (Basel) 2019 Jan 30;11(2). Epub 2019 Jan 30.

School of Medical and Health Sciences, Edith Cowan University, Perth, WA 6027, Australia.

Cutaneous melanoma circulating tumour cells (CTCs) are phenotypically and molecularly heterogeneous. We profiled the gene expression of CTC subpopulations immunomagnetic-captured by targeting either the melanoma-associated marker, MCSP, or the melanoma-initiating marker, ABCB5. Firstly, the expression of a subset of melanoma genes was investigated by RT-PCR in MCSP-enriched and ABCB5-enriched CTCs isolated from a total of 59 blood draws from 39 melanoma cases. Read More

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http://dx.doi.org/10.3390/cancers11020157DOI Listing
January 2019

Generalized Vaccinia After Smallpox Vaccination With Concomitant Primary Epstein Barr Virus Infection.

Fed Pract 2017 Mar;34(3):34-36

is the general medical officer at Combat Logistics Battalion 3 in Kaneohe Bay, Hawaii. is the general medical officer at Fort Belvoir Community Hospital Dermatology Clinic in Virginia.

A patient presents with a spreading rash 9 days following inoculation with the smallpox vaccine. Read More

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Melanoma Registry Underreporting in the Veterans Health Administration.

Fed Pract 2016 Aug;33(Suppl 5):55S-59S

is a physician, and is the cancer care program manager, both at VA Puget Sound Health Care System. is the VISN 20 data manager for the Store and Forward Teledermatology Program. Dr. Raugi is a professor of dermatology, and , , , and are students; all at the University of Washington in Seattle.

Use of local SNOMED codes and clerical errors led to the underreporting of melanomas despite having an in-house reporting system and understanding reporting requirements. Read More

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Solving the VA Physician Shortage Problem: The Right Thing to Do.

Authors:
Lawrence S Chan

Fed Pract 2016 Oct;33(10):8-11

is an attending physician at the Jesse Brown VAMC and at the Captain James A. Lovell Federal Health Care Center, both in Chicago, Illinois. He also is the Dr. Orville J. Stone Professor of Dermatology and head of the dermatology department at the University of Illinois in Chicago.

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October 2016

Management of Psoriasis and Psoriatic Arthritis in a Multidisciplinary Rheumatology/Dermatology Clinic.

Fed Pract 2015 Dec;32(Suppl 12):14S-20S

is an assistant professor of medicine and an attending physician in the Division of Rheumatology, is the chief of dermatology, and is the rheumatology program director as well as director of rheumatology research and musculoskeletal ultrasound, all at the Warren Alpert Medical School of Brown University. Dr. Cunha and Dr. Qureshi are attending physicians and Dr. Reginato is acting chief of rheumatology, all at the Providence VA Medical Center.

Early diagnosis, use of newly developed targeted therapies, and a multispecialty approach are essential for the treatment of patients with psoriasis and psoriatic arthritis. Read More

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December 2015

Novel insights into FOXOlogy: FOXOs and their putative role in thyroid carcinogenesis.

Expert Rev Endocrinol Metab 2011 Jan;6(1):63-69

a Clinic of Endocrinology and Nephrology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, D-04103 Leipzig, Germany.

FOXO transcription factors regulate genes directly involved in the control of cell cycle arrest, apoptosis, DNA damage repair and antioxidative defense mechanisms. Genetic FOXO alterations and inactivation of FOXOs through oncogenic signaling cascades have been identified in several human cancers and contribute to uncoordinated cellular proliferation. To date, little is known about FOXOs in the thyroid context. Read More

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http://dx.doi.org/10.1586/eem.10.70DOI Listing
January 2011

Pharmacological advances in pemphigoid.

Curr Opin Pharmacol 2019 Feb 12;46:34-43. Epub 2019 Feb 12.

Department of Dermatology, Philipps University, Baldingerstr., Marburg, Germany. Electronic address:

Pemphigoid is the most common autoimmune blistering disease. IgG and IgE autoantibodies against the hemidesmosomal antigens Bullous Pemphigoid (BP) 180 and BP230 are of pathogenic relevance, since autoantibody-antigen binding results in complement activation, immune cells infiltration, impaired hemidesmosomal function, and loss of dermal-epidermal adhesion. Systemic steroids and immunosuppressants are frontline therapies in pemphigoid, but result in substantial morbidity and increased mortality. Read More

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http://dx.doi.org/10.1016/j.coph.2018.12.007DOI Listing
February 2019

Successful treatment of chromoblastomycosis using ALA-PDT in a patient with leukopenia.

Photodiagnosis Photodyn Ther 2019 Feb 12. Epub 2019 Feb 12.

Department of Dermatology, Nanfang Hospital, Southern Medical University, 1838 North Avenue, Guangzhou 510515, China. Electronic address:

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.013DOI Listing
February 2019

High dietary fat intake induces a microbiota signature that promotes food allergy.

J Allergy Clin Immunol 2019 Feb 12. Epub 2019 Feb 12.

Institute of Pathology, Department of Experimental Pathology, University of Bern, Bern, Switzerland. Electronic address:

Background: Diet-induced obesity and food allergies rise in tandem, but a potential cause-and-effect relationship between these diseases of affluence remains to be tested.

Objective: To test the role of high dietary fat intake, diet-induced obesity and associated changes in gut microbial community structure on food allergy pathogenesis.

Methods: Mice were fed a high fat diet (HFD) for 12 weeks prior to food allergen sensitization on an atopic dermatitis-like skin lesion followed by intra-gastric allergen challenge to induce experimental food allergy. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.043DOI Listing
February 2019

Medicare incentive payments to U.S. ophthalmologists for use of electronic health records: 2011-2016.

Ophthalmology 2019 Feb 12. Epub 2019 Feb 12.

Department of Ophthalmology, University of Washington, Seattle, Washington.

Purpose: To investigate ophthalmologists' rate of attestation to meaningful use (MU) of their electronic health record (EHR) systems in the Medicare EHR Incentive Program and their continuity and success in receiving payments in comparison with other specialties.

Design: Administrative database study.

Participants: Eligible professionals participating in the Medicare EHR Incentive Program. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.01.030DOI Listing
February 2019

Revival of favus in Japan caused by Trichophyton schoenleinii.

J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Nara Medical University, Kashihara, Japan.

Favus is a type of dermatophytosis known to produce yellow scutula around hair follicles. Most cases of this disease worldwide are infections of Trichophyton schoenleinii. Favus has rarely been reported in Japan throughout the last four decades, and T. Read More

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http://dx.doi.org/10.1111/1346-8138.14804DOI Listing
February 2019

Ultrasonography for early detection of non-infectious necrotizing fasciitis secondary to cutaneous loxoscelism.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.

A 50-year-old woman consulted to the emergency department for painful erythematous swelling on her forearm hours after a spider bite. The patient had spent the evening cleaning the outside of her home, located in the periphery of an urban area, next to a ravine, on the western Mediterranean Basin, when she identified a spider on the dorsum of her forearm. She described it as a light-brown coloured spider, with darker long legs, between 1 and 1,5 cm in size. Read More

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http://dx.doi.org/10.1111/jdv.15503DOI Listing
February 2019

Comparison of efficacy of cold trypsinization versus warm trypsinization in preparation of autologous noncultured epidermal cell suspension for treatment of stable vitiligo.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.

Surgical modalities are the mainstay of treatment for medically resistant vitiligo. Among various techniques, non-cultured epidermal cell suspension (NCES) has proven to be an effective and most accepted technique because of its advantage of treating large areas. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/jdv.15502DOI Listing
February 2019

Terbinafine-resistant strain of Trichophyton interdigitale strain isolated from a tinea pedis patient.

J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

Trichophyton interdigitale is an anthropophilic species that is frequently isolated from tinea unguium and tinea pedis throughout the world. In the present study, antifungal susceptibility testing was performed on T. interdigitale isolates from Japanese patients (isolated in 2017-2018; 24 strains) to assess itraconazole (ITZ) and terbinafine (TRF) susceptibility of these strains. Read More

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http://dx.doi.org/10.1111/1346-8138.14809DOI Listing
February 2019

Relationship between dermoscopy and pathology in a case of clonal-type pigmented Bowen's disease: Observation with vertical-view dermoscopy.

J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Osaka Police Hospital, Osaka, Japan.

Pigmented Bowen's disease (pBD) is a subtype of Bowen's disease, which presents clinically as a well-circumscribed, hyperpigmented plaque. Its clinical manifestations are not fully characterized, and differential diagnoses include various pigmented skin lesions. Dermoscopy could be useful for the diagnosis, although nothing has been reported on the dermoscopic features of clonal-type pBD. Read More

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http://dx.doi.org/10.1111/1346-8138.14814DOI Listing
February 2019

Eczematous eruption during anti-interleukin 17 treatment of psoriasis: an emerging condition.

Br J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Health Sciences, University Magna Graecia, Catanzaro, Italy.

Major advances in psoriasis pathogenesis gave rise to development of new effective drugs for its treatment. Particularly, biologic drugs revolutionized disease management. TNF-α inhibitors represented the opening available biologic class since 2000. Read More

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http://dx.doi.org/10.1111/bjd.17779DOI Listing
February 2019

Practice-Based Differences in Pediatric Discoid Lupus Erythematosus.

Br J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Northwestern University Feinberg School of Medicine, Department of Dermatology and Pediatrics, Chicago, Illinois, United States.

Background: Children with discoid lupus erythematosus (DLE) are at risk for disfigurement and progression to systemic lupus erythematosus (SLE). Consensus is lacking regarding optimal care of children with DLE.

Objectives: We compared practice patterns among pediatric dermatologists/rheumatologists treating pediatric DLE. Read More

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http://dx.doi.org/10.1111/bjd.17780DOI Listing
February 2019

A review of the etiologies, clinical characteristics, and treatment of canities.

Int J Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Hair pigmentation is regulated by follicular melanogenesis, in which the process consists of melanin formation and transfer to keratinocytes in the hair shaft. Human hair follicles contain two types of melanin: the brown-black eumelanin and yellow-red pheomelanin. Eumelanin is commonly present in black and brown hair while pheomelanin is found in auburn and blonde hair. Read More

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http://dx.doi.org/10.1111/ijd.14399DOI Listing
February 2019

Immunoglobulin G and Subclasses as Potential Biomarkers in Metastatic Melanoma Patients Starting Checkpoint Inhibitor Treatment.

J Immunother 2019 Feb 13. Epub 2019 Feb 13.

Institute of Immunobiology.

Checkpoint inhibitors have improved survival of metastatic melanoma. However, reliable biomarkers to predict response are still needed. Immunoglobulin G (IgG) antibody subclasses reflect immunocompetence in individuals and are known to be involved in essential functions in our immune system. Read More

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http://dx.doi.org/10.1097/CJI.0000000000000255DOI Listing
February 2019

Descriptors of Vulvodynia: A Multisocietal Definition Consensus (International Society for the Study of Vulvovaginal Disease, the International Society for the Study of Women Sexual Health, and the International Pelvic Pain Society).

J Low Genit Tract Dis 2019 Feb 12. Epub 2019 Feb 12.

Department of Obstetrics and Gynecology, The George Washington University School of Medicine and Health Sciences and the Center for Vulvovaginal Disorders, Washington, DC.

Objectives: Three scientific societies, the International Society for the Study of Vulvovaginal Disease (ISSVD), the International Society for the Study of Women Sexual Health (ISSWSH), and the International Pelvic Pain Society (IPPS) developed the "2015 ISSVD, ISSWSH, and IPPS Consensus Terminology and Classification of Persistent Vulvar Pain and Vulvodynia" (referred to as the "2015 consensus terminology").The terminology included 11 descriptors of vulvodynia. However, the definitions of the descriptors were not included in the 2015 consensus terminology publications. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000461DOI Listing
February 2019

Hsp70 Gene Polymorphisms Are Associated With Disease Susceptibility and HRQOL Improvement in Chinese Han Population With Systemic Lupus Erythematosus.

J Clin Rheumatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, Anhui, China.

Objectives: The aim of this study is to investigate whether heat shock protein 70 (Hsp70) gene polymorphisms are implicated in systemic lupus erythematous (SLE) susceptibility, the efficacy of glucocorticoids (GCs) treatment, and improvement of health-related quality of life.

Methods: A total of 499 SLE patients and 499 controls were included in a case-control study, and 468 SLE patients treated with GCs for 12 weeks were involved in a follow-up study. Patients who completed the 12-week follow-up were divided into GCs-sensitive and GCs-insensitive group by using the SLE disease activity index. Read More

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http://dx.doi.org/10.1097/RHU.0000000000000986DOI Listing
February 2019

Towards personalized treatment in atopic dermatitis.

Expert Opin Biol Ther 2019 Feb 15. Epub 2019 Feb 15.

a National Expertise Center for Atopic Dermatitis. Department of Dermatology and Allergology , University Medical Center Utrecht , The Netherlands .

Introduction: For many years, oral immunosuppressive drugs such as cyclosporine A, azathioprine, mycophenolic acid and methotrexate were the only treatment options, in addition to topical treatment, in patients with severe atopic dermatitis (AD). Dupilumab, a monoclonal antibody targeting the IL-4 receptor alpha, is the first antibody-based treatment commercially available for the treatment of AD. In the near future, more antibody-based treatments and small molecules will become available in the treatment of severe AD. Read More

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http://dx.doi.org/10.1080/14712598.2019.1583204DOI Listing
February 2019

Treatment in metastatic melanoma - Time to re-think.

Ann Oncol 2019 Feb 15. Epub 2019 Feb 15.

University Hospital Essen, Department of Dermatology, Essen, Germany & German Cancer Consortium, Heidelberg, Germany.

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http://dx.doi.org/10.1093/annonc/mdz050DOI Listing
February 2019

Health Care and Cybersecurity: Bibliometric Analysis of the Literature.

J Med Internet Res 2019 Feb 15;21(2):e12644. Epub 2019 Feb 15.

Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA, United States.

Background: Over the past decade, clinical care has become globally dependent on information technology. The cybersecurity of health care information systems is now an essential component of safe, reliable, and effective health care delivery.

Objective: The objective of this study was to provide an overview of the literature at the intersection of cybersecurity and health care delivery. Read More

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https://www.jmir.org/2019/2/e12644/
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http://dx.doi.org/10.2196/12644DOI Listing
February 2019
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Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study.

Clin Exp Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Medical Research Ctr.of Orthopaedics, Chinese Academy of Medical Sciences; Beijing Key Lab. for Genetic Res.of Skeletal Deformity; Dept.of Central Laboratory, Peking Union Medical College Hosp., Peking Union Med. College and Chinese Academy of Med.Science.

Objectives: To evaluate the clinical efficacy of bisphosphonates treatment for spinal bone marrow oedema (BME) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.

Methods: SAPHO syndrome patients presenting to Peking Union Medical College Hospital from 2015 to 2016 were recruited. Patients were administered pamidronate disodium 1 mg/kg/d intravenously, for 3 days, at baseline and 3 months later. Read More

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February 2019

Impregnated acetate gauze compared with lipido-colloid contact layer at dressing removal pain: a single-blind cross-over randomised control trial.

J Wound Care 2019 Feb;28(2):89-101

Dermatologist; Dermatology and out-patients consultations, Hôpital Dupuytren, Limoges, France.

Objective:: To evaluate the performance of Jelonet Plus (JP) and UrgoTul (UT), assessing pain at dressing removal when managing acute or chronic wounds at granulation and epithelialisation stages.

Methods:: This was a randomised, multicentre, controlled single-blinded study using a cross-over design. Hospitalised and ambulatory patients presenting with non-infected acute or chronic wounds (at least 40% of wound area of ≤100cm covered with granulation tissue) were randomly allocated to be treated with either JP or UT dressings applied according to a standardised local care procedure for two days. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.2.89DOI Listing
February 2019

Fluorescence-Advanced Videodermatoscopy: A promising and potential technique for the in vivo evaluation of vitiligo.

Dermatol Ther 2019 Feb 14:e12863. Epub 2019 Feb 14.

Division of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1111/dth.12863DOI Listing
February 2019

Mechanism of action of 4-substituted phenols to induce vitiligo and anti-melanoma immunity.

Pigment Cell Melanoma Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Infection& Immunity Institute, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Monobenzone is a 4-substituted phenol that can induce vitiligo and antimelanoma immunity. We investigated the influence of the chemical structure on the biological activity of a series of structurally-related 4-substituted phenols. All phenols inhibited cellular melanin synthesis, and eight of ten phenols inhibited tyrosinase activity, using the MBTH assay. Read More

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http://dx.doi.org/10.1111/pcmr.12774DOI Listing
February 2019

Long noncoding RNA expression profile from cryptococcal meningitis patients identifies DPY19L1p1 as a new disease marker.

CNS Neurosci Ther 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Venereology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Aims: LncRNAs play a vital role in the pathological and physiological process. This study aimed to explore the involvement of lncRNAs in cryptococcal meningitis.

Methods: Microarray was performed in cryptococcal meningitis patients, and then, GO and KEGG pathways were analyzed. Read More

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http://dx.doi.org/10.1111/cns.13109DOI Listing
February 2019

Extended surgical safety margins and ulceration are associated with an improved prognosis in pleomorphic dermal sarcomas (PDS).

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Background: Pleomorphic dermal sarcomas (PDS) are frequent UV-induced sarcomas of the skin of intermediate grade malignant potential. Despite the fact that PDS have a noteworthy potential to recur (up to 28%) as well as to metastasize (up to 20%), there are no specific clinical guidelines with respect to follow-up these patients. Moreover, little is known about clinical, histological or molecular prognostic factors in PDS. Read More

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http://dx.doi.org/10.1111/jdv.15493DOI Listing
February 2019