208,480 results match your criteria Dermatology Times[Journal]


The effect of C-X-C motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy.

Photodiagnosis Photodyn Ther 2019 Apr 22. Epub 2019 Apr 22.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: Active recruitment of inflammatory cells into tumors may be vital for antitumor immunity in cutaneous squamous cell carcinoma (cSCC) after photodynamic therapy. Chemokines play important roles in inflammatory cell recruitment. Moreover, C-X-C motif chemokine ligand 13 (CXCL13) is thought to be a pivotal chemokine involved in inflammatory response and antitumor effect. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.04.018DOI Listing

Enhanced Intrinsic Skin Aging in Nephropathic Cystinosis Assessed by High-Definition Optical Coherence Tomography.

J Invest Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatrics, University Hospitals Leuven, campus Gasthuisberg, Leuven, Belgium; Department of Development & Regeneration, KU Leuven, campus Gasthuisberg, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jid.2019.03.1153DOI Listing

Itching for an Answer: A Review of Potential Mechanisms of Scalp Itch in Psoriasis.

Exp Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Dr Phillip Frost, Department of Dermatology and Cutaneous Surgery and 2Miami Itch Center Miller School of Medicine.

Scalp psoriatic itch is a common complaint and often poses a therapeutic challenge. The pathophysiology of this phenomenon is unclear. The unique anatomy of the scalp contains richly innervated hair follicles, abundant vasculature and perifollicular inflammatory cytokines which may all contribute to this common sensory complaint. Read More

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http://dx.doi.org/10.1111/exd.13947DOI Listing

Lungs, methotrexate and psoriasis: reply from author.

Clin Exp Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Departments of Respiratory Medicine, Ninewells Hospital, Dundee, UK.

There may be a group of patients with psoriasis who are at increased risk of developing interstitial lung disease and identifying these individuals is desirable. However, at the present time we do not believe that routine screening with chest CT scanning is indicated nor any proposed preventative medical treatments both of which may have side-effects. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/ced.13994DOI Listing

Multiple primary melanoma with the Meyerson phenomenon in a young patient.

Melanoma Res 2019 Jun;29(3):325-327

Departments of Dermatology.

Meyerson phenomenon (MP), also called halo eczema or halo dermatitis, was first described in 1971 as a symmetric eczematous halo around acquired melanocytic nevi. Since then, cases of MP have been described in any kind of melanocytic nevi and also in non-melanocytic tumors. To the best of our knowledge, only four cases of melanoma associated with MP have been reported. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000583DOI Listing

Diagnosis and treatment of dermatologic diseases in inflammatory bowel disease.

Curr Opin Gastroenterol 2019 Apr 22. Epub 2019 Apr 22.

Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Purpose Of Review: Dermatologic manifestations in patients with inflammatory bowel disease (IBD) are increasingly recognized as related disorders, secondary to specific therapies used to treat IBD, or complications of IBD itself. These dermatologic manifestations can be difficult to manage.

Recent Findings: We summarize three categories of dermatologic manifestations in this review: extraintestinal cutaneous disorders, paradoxical manifestations to biologic therapies, and other drug-induced cutaneous manifestations. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000538DOI Listing
April 2019
1 Read

Performance Measures in Dermatologic Surgery: A Review of the Literature and Future Directions.

Dermatol Surg 2019 Apr 23. Epub 2019 Apr 23.

Department of Dermatology, University of California San Francisco, San Francisco, California.

Background: In recent years, health care reform initiatives have aimed to assess quality of care through the use of performance measures. Multiple specialties, including dermatology, have implemented registries to track and report health care quality.

Objective: The authors review the history and rationale for assessing quality in dermatologic surgery. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001938DOI Listing

FARP1 Facilitates Cell Proliferation Through Modulating MAPK Signaling Pathway in Cutaneous Melanoma.

Am J Dermatopathol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, People's Republic of China.

Purpose: The purpose of our study was to investigate the biological functions of FARP1 gene in cutaneous melanoma.

Methods: The mRNA expression level of FARP1 in cutaneous melanoma was analyzed based on the data obtained from ONCOMINE and The Cancer Genome Atlas database. Kaplan-Meier analysis was conducted to explore the association between FARP1 expression and the overall survival time of patients with cutaneous melanoma. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001426DOI Listing

Histopathological and Immunohistochemical Characteristics of Measles Exanthema: A Study of a Series of 13 Adult Cases and Review of the Literature.

Am J Dermatopathol 2019 Apr 18. Epub 2019 Apr 18.

Dermatopathology Duisburg, Duisburg, Germany.

Despite available vaccination, measles is one of the leading causes of death among young children in developing countries. In clinical practice, the spectrum of differential diagnoses of morbilliform exanthemas associated with fever is wide, and it can be hard to differentiate from other infectious eruptions, especially in adults or in atypical courses in immunocompromised patients. The goal of our study was to identify characteristic histomorphological and immunohistochemical patterns of measles exanthema through the study of 13 skin biopsy specimens obtained from 13 patients with this disease and a review of cases in the literature. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001431DOI Listing

A case of postoperative bullous allergic contact dermatitis due to injection with lidocaine.

Contact Dermatitis 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, University of Groningen, University Medical Center Groningen, The Netherlands.

Injected local anaesthetics have been reported to cause delayed-type reactions. (1 - 3) A bullous type IV allergic reaction caused by lidocaine injected during a skin biopsy was published once. (4) This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/cod.13297DOI Listing

Finalizing the international core domain set for peripheral vascular malformations: the OVAMA project.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands.

There is a variety of outcome reporting in the clinical research on peripheral vascular malformations including capillary, venous, lymphatic, arteriovenous and combined malformations. Without harmonization of outcome measures, treatments cannot be properly compared. This hampers the development of evidence-based treatment guidelines, urgently needed for these challenging congenital conditions. Read More

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http://dx.doi.org/10.1111/bjd.18043DOI Listing

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculous drugs: two case reports and a review of the literature.

Contact Dermatitis 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, Cliniques universitaires Saint-Luc, Brussels, Belgium.

Background: Patients suffering from drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculous drugs often need to be re-treated rapidly. Patch tests prior to the re-introduction of antituberculosis drugs are rarely performed.

Objectives: We aim to highlight those drugs most often involved in DRESS from antituberculosis drugs, illustrate the potential value of patch tests to identify these culprit(s), and provide insights in how to rapidly re-treat these patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cod.13296
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http://dx.doi.org/10.1111/cod.13296DOI Listing
April 2019
1 Read

"It's like the bad guy in a movie who just doesn't die": A qualitative exploration of young people's adaptation to eczema and implications for self-care.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Primary Care and Population Science, Faculty of Medicine, University of Southampton, Southampton, U.K.

Background: Eczema is a common childhood inflammatory skin condition, affecting more than 1 in 5 children. A popular perception is children 'outgrow eczema', although epidemiological studies have shown that, for many, eczema follows a life-long episodic course. The aim of this study was to explore the perceptions of young people about the nature of their eczema and how these perceptions relate to their self-care and adapting to living with eczema. Read More

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http://dx.doi.org/10.1111/bjd.18046DOI Listing
April 2019
6 Reads

A Multi Year Cross Sectional Study of US National Prescribing Patterns of First Generation Sedating Antihistamines in Older Adults with Skin Disease.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, Stanford University School of Medicine, Stanford, California.

Background: First generation antihistamines (FGA) medications are classified as "potentially inappropriate" for use in older adults. However, the prevalence and factors associated with their use have not been studied.

Objective: To examine FGA prescriptions in older adults who visit dermatology offices, and compare them to those of younger adults, and to those who visit primary care physicians (PCP). Read More

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http://dx.doi.org/10.1111/bjd.18042DOI Listing
April 2019
1 Read

Conceptual, statistical and clinical interpretation of results from: Cryosurgery combined with topical interventions for actinic keratosis: reply from the authors.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Frauenlobstraβe 9-11, 80337, Munich, Germany.

We thank you for the opportunity to reply to the comments raised by Jayaraj and Kumarasamy. We appreciate their interest in our research and welcome the constructive discussion on the issues thats may arise from pooling different interventions for actinic keratosis (AK) and from not presenting a funnel plot. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/bjd.18039DOI Listing

Postzygotic HRAS mutation in heterochromia of straight scalp hair.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine Freiburg, Germany.

The growth of hair of two distinct colors in one person is a well-described phenomenon defined as heterochromia of the scalp. We studied one case with heterochromia of straight scalp hair associated with a keratinocytic epidermal nevus. Samples from lesional skin were obtained for histopathological evaluation and for DNA isolation. Read More

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http://dx.doi.org/10.1111/bjd.18045DOI Listing

The conventional protocol versus a protocol including illumination with a fabric-based biophotonic device (the Phosistos protocol) in photodynamic therapy for actinic keratosis: a randomized, controlled, non-inferiority clinical study.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Univ. Lille, INSERM, CHU Lille, U1189 - ONCO-THAI - Image Assisted Laser Therapy for Oncology, F-59000, Lille, France.

Background: Topical photodynamic therapy (PDT) using methyl aminolevulinate is a non-invasive treatment option suitable to treat clinical and subclinical actinic keratosis (AK) over a large area (field cancerization). The most widely used, conventional protocol in Europe includes illumination with a red-light lamp. This illumination commonly causes pain, and patients often cannot complete the treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18048
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http://dx.doi.org/10.1111/bjd.18048DOI Listing
April 2019
1 Read

Treatment of moderate-to-severe Atopic dermatitis with dupilumab in real clinical practice. A multicentre, retrospective case series.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Spain.

Atopic dermatitis (AD) is a chronic, inflammatory and pruritic skin disease, with a prevalence of 1-3% of the adult population. AD physiopathology is multifactorial, the interaction of genetic disposition and environmental triggers coexist with a marked skin barrier dysfunction and a Type 2 (T2)-driven immune dysregulation. In AD, Th2 lymphocytes secrete several cytokines, where IL-4/IL-13 play a key role in the proinflammatory loop, decreasing the expression of structural proteins of the epidermis, and leading to the formation of inflammatory and very pruritic lesions. Read More

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http://dx.doi.org/10.1111/bjd.18041DOI Listing

Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma: New insight into skin epithelial homeostasis and avenues for treatment.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Pachyonychia congenita (PC), a rare genodermatosis, primarily affects ectoderm-derived epithelial appendages and typically includes oral leukokeratosis, nail dystrophy, and very painful palmoplantar keratoderma (PPK). PC dramatically impacts quality of life though it does not affect lifespan. PC can arise from mutations in any of the wound repair-associated keratin genes KRT6A, KRT6B, KRT6C, KRT16, or KRT17. Read More

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http://dx.doi.org/10.1111/bjd.18033DOI Listing

The optimal oral biopsy site for diagnosis of mucous membrane pemphigoid and pemphigus vulgaris.

Br J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Oral Medicine, Dental Institute, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Introduction: Accepted 'standard practice' for the diagnosis of immunobullous disease (IBD) is a perilesional sample for direct immunofluorescence (DIF). Our aim was to compare diagnostic outcomes of a normal buccal punch biopsy (NBPB) with a perilesional biopsy (PLB) for mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV).

Method: A retrospective analysis of 251 DIF positive MMP and 77 DIF positive PV patients was undertaken. Read More

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http://dx.doi.org/10.1111/bjd.18032DOI Listing

Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer.

JAMA Oncol 2019 Apr 25. Epub 2019 Apr 25.

Institute of Immunobiology, Kantonsspital St Gallen, St Gallen, Switzerland.

Importance: Immunotherapy with checkpoint inhibitors targeting the PD-1 (programmed cell death 1) axis has brought notable progress in patients with non-small cell lung cancer (NSCLC) and other cancers. However, autoimmune toxic effects are frequent and poorly understood, making it important to understand the pathophysiologic processes of autoimmune adverse effects induced by checkpoint inhibitor therapy.

Objective: To gain mechanistic insight into autoimmune skin toxic effects induced by anti-PD-1 treatment in patients with non-small cell lung cancer. Read More

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2019.0402DOI Listing
April 2019
1 Read

With Feathers.

JAMA Oncol 2019 Apr 25. Epub 2019 Apr 25.

Dermatology, UMass Memorial Medical Center, Worcester, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2019.0202DOI Listing

Ex vivo confocal laser scanning microscopy: an innovative method for direct immunofluorescence of cutaneous vasculitis.

J Biophotonics 2019 Apr 25:e201800425. Epub 2019 Apr 25.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Germany.

Introduction: Ex vivo confocal laser scanning microscopy (ex vivo CLSM) offers an innovative diagnostic approach through vertical scanning of skin samples with a resolution close to conventional histology. In addition, it enables fluorescence detection in tissues.

Objective: To assess the applicability of ex vivo CLSM in the detection of vascular immune complexes in cutaneous vasculitis and to compare its diagnostic accuracy with direct immunofluorescence (DIF) microscopy. Read More

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http://dx.doi.org/10.1002/jbio.201800425DOI Listing

Efficacy and tolerability of using platelet-rich plasma versus chemical peeling in periorbital hyperpigmentation.

J Cosmet Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Background: Various therapeutic modalities for periorbital hyperpigmentation (POH) have been proposed.

Objective: This study was designed to compare the efficacy and tolerability of autologous platelet-rich plasma (PRP) and chemical peeling in POH.

Subjects And Methods: Forty-two patients were enrolled in this study and randomly subdivided into two groups. Read More

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http://dx.doi.org/10.1111/jocd.12964DOI Listing

YKL-40 augments the proliferation of HaCaT cells via the extracellular regulatory kinase pathway.

J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/1346-8138.14898DOI Listing

Case of severe bullous erythema including intertrigo-like eruptions with angioedema induced by pegylated liposomal doxorubicin.

J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Pegylated liposomal doxorubicin (PLD) is an anthracycline anticancer agent used in ovarian cancer and a form of doxorubicin enclosed in pegylated liposomes. There are only a few reports on intertrigo-like eruptions caused by PLD. We describe the first case of severe bullous erythema, including intertrigo-like eruptions with angioedema, induced by PLD in Japan. Read More

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http://dx.doi.org/10.1111/1346-8138.14895DOI Listing

Usability testing of MySkinSelfie- a mobile phone application for skin self-monitoring.

Clin Exp Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Open Lab, School of Computing Science, Newcastle University, NE4 5TG.

Tele-dermatology generally involves doctors taking images of patients. However, patients increasingly want to own or have easy access to their health data. Myskinselfie (http://myskinselfie. Read More

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http://dx.doi.org/10.1111/ced.13995DOI Listing

Case of ultraviolet B-mediated photosensitivity during the administration of voriconazole.

J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/1346-8138.14874DOI Listing

Diagnostic challenges in systemic pruritic erythema: History played a key role for diagnosis of trichinellosis.

J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Division of Dermatology, Mito Kyodo General Hospital, University of Tsukuba, Mito, Japan.

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http://dx.doi.org/10.1111/1346-8138.14892DOI Listing

Pemphigus-like hypereosinophilic syndrome with FIP1L1-PDGFRA fusion gene: A challenging and uncommon clinical presentation.

J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Dermatology, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain.

Hypereosinophilic syndrome (HES) is often associated with cutaneous manifestations, mostly pruritic lesions, urticaria and angioedema. Mucosal lesions are rarely seen in HES but, when present, are usually the first manifestation of the disease. The clinical presentation may be heterogeneous, including erosions, aphthae or ulcers, and can be easily confused with other mucocutaneous disorders. Read More

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http://dx.doi.org/10.1111/1346-8138.14888DOI Listing

Safety and Effectiveness of Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Patients With Atrial Fibrillation and Anemia: A Retrospective Cohort Study.

J Am Heart Assoc 2019 May;8(9):e012029

1 Division of Cardiovascular Medicine Chang Gung Memorial Hospital Linkou Medical Center Taoyuan Taiwan.

Background Major randomized trials assessing non-vitamin K antagonist oral anticoagulants ( NOAC s) for stroke prevention in atrial fibrillation generally excluded patients with hemoglobin <10 g/dL. This study evaluated the safety and effectiveness of NOAC s in patients with atrial fibrillation and anemia. Methods and Results A cohort study based on electronic medical records was conducted from 2010 to 2017 at a multicenter healthcare provider in Taiwan. Read More

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http://dx.doi.org/10.1161/JAHA.119.012029DOI Listing

Beyond appearance: An unusual manifestation of isolated oral secondary syphilis.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419845566

3 Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University of Rome, Rome, Italy.

Syphilis is a sexually acquired chronic infection caused by Treponema pallidum and is characterized by a variety of clinical manifestations. The secondary stage of the disease results from the hematogenous and lymphatic dissemination of treponemes after a few weeks or months, and it is characterized by recurrent activity of the disease, with muco-cutaneous as well as systemic manifestations. Mucosal lesions range from small, superficial ulcers that resemble painless aphthae to large gray plaques, and they are generally associated with systemic manifestations of the disease. Read More

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http://dx.doi.org/10.1177/2058738419845566DOI Listing

Clinicopathologic Features and Prognostic Factors of Primary Cutaneous Melanoma: a Multicenter Study in Korea.

J Korean Med Sci 2019 Apr 29;34(16):e126. Epub 2019 Apr 29.

Department of Dermatology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

Background: Malignant melanoma is a cutaneous malignancy with a high mortality rate and high potential for metastases. Detailed information on the clinicopathologic characteristics and prognostic factors of cutaneous melanoma is currently limited in Korea. This study aimed to identify the epidemiological and clinicopathologic characteristics of primary cutaneous melanoma in Korean patients, and to assess which prognostic variables could influence both the development of metastases in primary cutaneous melanoma and overall survival (OS). Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e126DOI Listing

Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation.

Stem Cells Transl Med 2019 Apr 24. Epub 2019 Apr 24.

Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, California, USA.

Ionizing radiation, commonly used in the treatment of solid tumors, has unintended but deleterious effects on overlying skin and is associated with chronic nonhealing wounds. Skin-derived mesenchymal stromal cells (SMSCs) are a pluripotent population of cells that are critically involved in skin homeostasis and wound healing. The aim of this study was to isolate and functionally characterize SMSCs from human skin that was previously irradiated as part of neoadjuvant or adjuvant cancer therapy. Read More

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http://dx.doi.org/10.1002/sctm.18-0112DOI Listing

Investigation of coenzyme Q10 levels and predisposing factors in patients with striae gravidarum.

J Cosmet Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Biochemistry, Istanbul Medipol University, Istanbul, Turkey.

Background: Striae gravidarum (SG) can cause pregnant women severe psychological stress.

Objective: This study aimed to compare primigravidas with and without SG concerning fasting blood coenzyme Q10 (CoQ10), age, skin type, family history, gestational weight gain, pre- and post-pregnancy BMI, daily water consumption during pregnancy, gender and weight of baby, and the educational level.

Methods: The study included 79 primigravidas in the gestational week of 36 or above. Read More

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http://dx.doi.org/10.1111/jocd.12971DOI Listing

Pioneers in Dermatology and Venereology: An Interview with Prof. Attila Dobozy.

Authors:
A Dobozy

J Eur Acad Dermatol Venereol 2019 May;33(5):805-806

Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.

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http://dx.doi.org/10.1111/jdv.15606DOI Listing

UV irradiation-induced DNA hypomethylation around WNT1 gene: implications for solar lentigines.

Exp Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Department of Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo Kutsukakecho, Toyoake, Aichi, Japan.

Wnt/β-catenin signaling promotes melanogenesis in melanocytes and also induces melanocytogenesis from melanocyte stem cells (McSCs). Previous study reported that WNT1, a ligand which activates Wnt/β-catenin signaling pathway, was more highly expressed in the epidermis at SLs than in normal skin areas, suggesting that WNT1 causes hyperpigmentation. To elucidate the mechanism by which WNT1 expression is increased in SLs, we examined the methylation of 5-carbon of cytosine (5mC), i. Read More

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http://dx.doi.org/10.1111/exd.13949DOI Listing

Depletion of Primary Cilium in Acral Melanoma.

J Cutan Pathol 2019 Apr 24. Epub 2019 Apr 24.

Stanford University School of Medicine, Stanford, CA.

Background: A eukaryotic cell's primary cilium (PC) is critical for cell signaling, migration and homeostasis. Primary cilium dysfunction has been demonstrated in several malignancies, but whether primary cilia loss occurs in acral melanoma has remained unknown. To address this, we examined the ciliation index (% melanocytes containing a PC) of patient-derived, biopsy-proven acral melanoma and compared these to benign acral nevi. Read More

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http://dx.doi.org/10.1111/cup.13484DOI Listing

A Tunisian family with a novel mutation in the gene CYP4F22 for lamellar ichthyosis and co-occurrence of hearing loss in a child due to mutation in the SLC26A4 gene.

Int J Dermatol 2019 Apr 25. Epub 2019 Apr 25.

Laboratory of Biomedical Genomics and Oncogenetics (LR11IPT05), University of Tunis El Manar, Pasteur Institut of Tunis, Tunis, Tunisia.

Background: Co-occurrence of two genetic diseases is challenging for accurate diagnosis and genetic counseling. The recent availability of whole exome sequencing (WES) has dramatically improved the molecular diagnosis of rare genetic diseases in particular in consanguineous populations.

Methods: We report here on a consanguineous family from Southern Tunisia including three members affected with congenital ichthyosis. Read More

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http://dx.doi.org/10.1111/ijd.14452DOI Listing

TT genotype of rs10036748 in TNIP1 shows better response to methotrexate in a Chinese population: a prospective cohort study.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Shanghai Institute of Dermatology and Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: Methotrexate (MTX) is an efficacious treatment for psoriasis; however, its widespread application is limited by its unpredictable efficacy.

Objectives: To investigate the association of clinical factors and variants of psoriasis susceptibility genes with clinical responses to MTX in a prospective cohort.

Methods: A total of 221 patients with psoriasis were recruited. Read More

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http://dx.doi.org/10.1111/bjd.17704DOI Listing

Skin Bleaching Among African and Afro-Caribbean Women in New York City: Primary Findings from a P30 Pilot Study.

Dermatol Ther (Heidelb) 2019 Apr 24. Epub 2019 Apr 24.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: The application of skin bleaching products to inhibit melanogenesis is a common practice within the African diaspora. Despite the adverse health effects of skin bleaching, rigorous studies investigating skin bleaching behavior among these populations in the United States are limited. In our P30 pilot study, we explored predictors of skin bleaching practice intensity among African and Afro-Caribbean women. Read More

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http://dx.doi.org/10.1007/s13555-019-0297-yDOI Listing

Malar rash is a predictor of subclinical airway inflammation in patients with systemic lupus erythematosus: a pilot study.

Clin Rheumatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Internal Medicine, University of Brescia, Brescia, Italy.

Background: Systemic lupus erythematosus (SLE) is a chronic, auto-immune, multi-organ disease that can affect both the skin and the lungs. Malar rash is a common skin manifestation of SLE and is linked to SLE disease activity, whereas lung involvement is a generally negative prognostic factor for these patients. However, a sensitive and non-invasive screening tool for potential lung involvement in SLE patients is still not available. Read More

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http://dx.doi.org/10.1007/s10067-019-04536-yDOI Listing

Comparison of physical and mental functioning among moderate-to-severe psoriasis patients on biologic versus oral therapy.

Arch Dermatol Res 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Keck School of Medicine of University of Southern California, 1975 Zonal Avenue, KAM 510, MC 9034, Los Angeles, CA, USA.

With the extensive variety of available treatments for psoriasis, it is paramount that clinicians understand the differences between therapies. A critical literature gap exists regarding the effects of different systemic therapies on physical and mental functioning in the US psoriasis population. We sought to compare the impact of biologic versus oral therapy on measures of physical and mental functioning among US adults with moderate-to-severe psoriasis. Read More

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http://dx.doi.org/10.1007/s00403-019-01918-9DOI Listing

Omalizumab induced Takotsubo syndrome: case report.

Eur Heart J Case Rep 2019 Mar 3;3(1):yty155. Epub 2019 Jan 3.

Cardiology Department, Santa Maria University Hospital (CHLN), Lisbon Academic Medical Centre, and Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Portugal.

Background: Omalizumab is a humanized monoclonal anti-immunoglobulin E antibody, approved for the treatment of spontaneous chronic urticaria, with high efficacy and an excellent safety profile. Although its adverse effects are rare, allergic reactions and cardiovascular events were previously described.

Case Summary: The authors describe the case of a 75-year-old woman, followed at the outpatient dermatology clinic due to spontaneous chronic urticaria, treated with omalizumab 300 mg every 4 weeks. Read More

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http://dx.doi.org/10.1093/ehjcr/yty155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439385PMC

Hemorrhagic bulla: a rare presentation of scabies.

Ann Transl Med 2019 Mar;7(5):107

Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China.

Scabies is a contagious skin disorder with multiple presentations, it can also cause nosocomial infection sometimes. Bullous scabies is its rare subtype with male predilection, and typically occurs in the elderly with a median age of 70 years. We herein report a 90-year-old man who was hospitalized in the ward presenting with generalized infection of scabies associated with hemorrhagic bullae on both feet and hands, and leading to a prevalence in the ward. Read More

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http://dx.doi.org/10.21037/atm.2019.02.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462643PMC

MPGN Type 3 Associated with Pemphigus Herpetiformis Mimicking PGNMID and Dermatitis Herpetiformis.

Case Rep Nephrol Dial 2019 Jan-Apr;9(1):15-24. Epub 2019 Mar 21.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

A 45-year-old man suffering from dermal blistering disease with proteinuria and hematuria underwent renal biopsy. The renal biopsy specimen suggested proliferative glomerulonephritis with monoclonal IgG deposits under routine light, immunofluorescence and electron microscopy. The staining for IgG subclasses (IgG1 and IgG2) and κ/λ light chain indicated secondary immune complex type MPGN type 3. Read More

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http://dx.doi.org/10.1159/000498939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465718PMC

Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation.

Anal Cell Pathol (Amst) 2019 25;2019:8389765. Epub 2019 Mar 25.

Department of Internal Medicine, Neurology and Dermatology, Clinic for Endocrinology and Nephrology, Section of Nephrology, University Hospital Leipzig, Leipzig, Germany.

Background: Chronic or intercurrent alterations of the immune system in patients with end-stage renal disease (CKD) and intermittent hemodialysis (CKD5D, HD) have been attributed to an acute rejection of renal allograft.

Methods: Leukocyte subsets in flow cytometry, complement activation, and concentrations of TGF, sCD30 (ELISA), and interleukins (CBA) of fifteen patients eligible for renal transplantation were analyzed before, during, and after a regular HD.

Results: Before HD, the median proportion of CD8+ effector cells, CD8+ CCR5+ effector cells, and HLA-DR+ regulatory T cells as well as the median concentration of soluble CD30 increased and naive CD8+ T cells decreased. Read More

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http://dx.doi.org/10.1155/2019/8389765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452532PMC