201,696 results match your criteria Dermatology Research and Practice [Journal]


The relationship between type 1 IFN and vasculopathy in anti-MDA5 antibody-positive dermatomyositis patients.

Rheumatology (Oxford) 2018 Dec 11. Epub 2018 Dec 11.

Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Japan.

Objectives: Based on the antibody profiles of inflammatory myositis patients, we investigated the type 1 IFN (T1-IFN) signature in serum and DM skin to determine the relationship between T1-IFN and vasculopathy in anti-melanoma differentiation-associated 5 gene (MDA5) antibody-positive DM patients.

Methods: We examined 47 patients with new-onset inflammatory myositis. We divided them into three groups: the anti-MDA5 antibody-positive patients (MDA5 group, n = 16), the anti-aminoacyl-tRNA synthetase antibody-positive patients (aminoacyl-tRNA synthetase group, n = 12), and the double-negative patients (n = 19). Read More

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December 2018
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In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Miller Research Building Molecular Imaging Service Center, Johns Hopkins University, Baltimore, Maryland.

Preclinical noninvasive imaging can be an indispensable tool for studying animal models of disease. In vivo imaging to assess anatomical, functional, and molecular features requires verification by a comparison to the macroscopic and microscopic morphological features, since all noninvasive in vivo imaging methods have much lower resolution than standard histopathology. Comprehensive pathological evaluation of the animal model is underutilized; yet, many institutions have veterinary or human pathologists with necessary comparative pathology expertise. Read More

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December 2018

KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer.

Cell Rep 2018 Dec;25(11):3006-3020.e7

Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA; Department of Urology, NYU School of Medicine, New York, NY 10016, USA. Electronic address:

There is a considerable need to identify those individuals with prostate cancer who have indolent disease. We propose that genes that control adult stem cell homeostasis in organs with slow turnover, such as the prostate, control cancer fate. One such gene, KLF4, overexpressed in murine prostate stem cells, regulates their homeostasis, blocks malignant transformation, and controls the self-renewal of tumor-initiating cells. Read More

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December 2018

Suction Blisters.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, University of California, San Francisco.

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December 2018

Use of Combination Systemic-Intratumoral HPV Vaccine to Treat Cutaneous Basaloid Squamous Cell Carcinomas-Reply.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

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December 2018

JAMA Dermatology.

Authors:

JAMA Dermatol 2018 Dec;154(12):1373

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December 2018

Clinical Characterization of Immunotherapy-Related Pruritus Among Patients Seen in 2 Oncodermatology Clinics.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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December 2018

Recurrent Bullous Eruption in a Young Woman.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, University Hospital Leipzig (UKL), Germany.

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December 2018

Use of Combination Systemic-Intratumoral HPV Vaccine to Treat Cutaneous Basaloid Squamous Cell Carcinomas.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

INSERM UMR-1137, IAME, University of Paris Diderot, Sorbonne Paris Cité, Laboratoire de Virologie, Hôpital Bichat.

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December 2018

Recalcitrant Vulvar Lichen Sclerosus Treated With Erbium YAG Laser.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, University of Rochester Medical Center, Rochester, New York.

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December 2018

Changes in cerebral oxygenation and cerebral blood flow during hemodialysis - A simultaneous near-infrared spectroscopy and positron emission tomography study.

J Cereb Blood Flow Metab 2018 Dec 12:271678X18818652. Epub 2018 Dec 12.

1 Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Near-infrared spectroscopy (NIRS) is used to monitor cerebral tissue oxygenation (rSO) depending on cerebral blood flow (CBF), cerebral blood volume and blood oxygen content. We explored whether NIRS might be a more easy applicable proxy to [O]HO positron emission tomography (PET) for detecting CBF changes during hemodialysis. Furthermore, we compared potential determinants of rSO and CBF. Read More

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December 2018

Rs3213758 in the Gene Associated with Susceptibility to Segmental Vitiligo in a Chinese Han Population.

Chin Med J (Engl) 2018 Dec;131(24):3022-3024

Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

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December 2018

Two subsequent metachronous diseases: Granuloma annulare and colon adenocarcinoma.

J Cancer Res Ther 2018 Dec;14(Supplement):S1247-S1248

Department of Pathology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey, ş.

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December 2018

Cutaneous metastasis in prostate cancer: Two cases with similar clinical findings.

J Cancer Res Ther 2018 Dec;14(Supplement):S1213-S1216

Department of Pathology, Düzce University, Düzce Medical School, Düzce, Turkey.

Cutaneous metastasis of prostate cancer is rare. Lesions in this type of skin metastasis are usually seen as suprapubic nodules. Here, we presented two cases with skin metastases of prostate cancer characterized by grouped cutaneous and subcutaneous nodules. Read More

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December 2018
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Overexpression of forkhead box M1 is associated poor survival in patients with nonsmall cell lung cancer.

J Cancer Res Ther 2018 Dec;14(Supplement):S1121-S1123

Department of Respiratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, P.R. China.

Aims: The association between forkhead box M1 (FOXM1) and survival of nonsmall cell lung cancer (NSCLC) has been extensively investigated. However, the results were conflicted and inconclusive. Therefore, we performed this meta-analysis to precisely estimate the association between FOXM1 and survival of NSCLC. Read More

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December 2018

Eruptive squamous cell carcinomas associated with programmed cell death protein-1 inhibitor therapy.

Indian J Dermatol Venereol Leprol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.

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December 2018

Ensuring precise beard and eyebrow shaping with laser: Innovative use of tongue depressor.

Indian J Dermatol Venereol Leprol 2018 Dec 11. Epub 2018 Dec 11.

Minal Specialised Clinic Dermatology, Sharjah, UAE.

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December 2018

Guidelines for Diagnosis and Treatment of Cutaneous Sarcomas: Dermatofibrosarcoma Protuberans.

Actas Dermosifiliogr 2018 Dec 4;109(10):868-877. Epub 2018 Jul 4.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Sarcomas comprise a broad group of tumors, many of whose biological behavior and aggressiveness differ from one type to another. The therapeutic approach is generally multidisciplinary and often complex. Developments in surgical and oncological dermatology during the last few decades have positioned dermatologists as specialists in the diagnosis and treatment of skin cancer. Read More

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December 2018
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Novel multiplex real-time quantitative PCR detecting system approach for direct detection of Candida auris and its relatives in spiked serum samples.

Future Microbiol 2018 Dec 12. Epub 2018 Dec 12.

Westerdijk Fungal Biodiversity Institute, Utrecht 3584, The Netherlands.

The multidrug-resistant opportunistic yeast species of Candida auris, Candida haemulonii, Candida duobushaemulonii and Candida pseudohaemulonii continue to endanger the healthcare settings around the globe. Due to the lack of a specific qPCR assay for detection of these species from clinical samples, we developed a multiplex qPCR assay. Analytical specificity and sensitivity showed 100% specificity and the sensitivity of up to ten genomes of target species with a high value of reproducibility (R >0. Read More

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December 2018

Immune Checkpoint Inhibitors-Induced Hepatitis.

Adv Exp Med Biol 2018 ;995:159-164

Department of Gastroenterology, Hepatology and Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Immune checkpoint inhibitors (ICIs) have been increasingly used for multiple cancer types in the past decade. ICIs include CTLA-4 inhibitors (e.g. Read More

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January 2018

Immune Checkpoint Inhibitors-Induced Colitis.

Adv Exp Med Biol 2018 ;995:151-157

Department of Gastroenterology, Hepatology and Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Immune checkpoint inhibitors (ICIs) have shown significant benefit in cancer patients, but are associated with immune-related adverse events (irAEs), that can affect the gastrointestinal tract resulting in diarrhea and colitis. IrAEs range from mild self-limiting to severe life-threatening disease, which potentially limit the use of these medications. Diagnosis of ICI-induced colitis is based on clinical symptoms, physical examination, stool tests, endoscopic evaluation, and/or imaging. Read More

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January 2018

Skin Reactions to Immune Checkpoint Inhibitors.

Adv Exp Med Biol 2018 ;995:117-129

Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

The novelty of immune checkpoint inhibitors has only recently led to the characterization of cutaneous adverse events (AEs). This, along with the substantial rate of cutaneous reactions, has left many clinicians without sufficient familiarity to diagnose and treat. Pruritus and rash are among the top five immune-related AEs reported in clinical trials for this class of therapy. Read More

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January 2018
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Monoclonal Antibodies for the Treatment of Melanoma: Present and Future Strategies.

Methods Mol Biol 2019 ;1904:83-108

Department of Clinical Pharmacology, Genentech Research and Early Development, South San Francisco, CA, USA.

Metastatic melanoma is a dreadful type of skin cancer arising due to uncontrolled proliferation of melanocytes. It has very poor prognosis, low 5-year survival rates and until recently there were only handful of treatment options for metastatic melanoma patients. The drugs that were approved for the treatment had low response rates and were associated with severe adverse events. Read More

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January 2019
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Propionibacterium (Cutibacterium) acnes Bacteriophage Therapy in Acne: Current Evidence and Future Perspectives.

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. Read More

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December 2018
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Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence.

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Plastic Surgery, Tan Tock Seng Hospital, Singapore, Republic of Singapore.

Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. Read More

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December 2018
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Optical coherence tomography imaging of melanoma skin cancer.

Lasers Med Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

No consensus guidelines exist on the use of optical coherence tomography (OCT) for diagnosis of cutaneous melanoma. The objectives of this review are to provide a descriptive review of the literature on characteristics of cutaneous melanomas seen on high-definition OCT (HD-OCT), speckle variance OCT (SV-OCT), and conventional OCT and to compare their diagnostic ability with that of histopathology. A review of PubMed and Google Scholar identified all available literature on OCT in melanoma skin cancer that included all in vivo and ex vivo studies on human or human tissues and excluded all studies on non-human subjects or animal studies. Read More

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December 2018
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Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies.

Osteoporos Int 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan.

We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1. Read More

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December 2018

Increased cryo-survival rate in ejaculated human sperm from infertile men following pre-freeze myo-inositol supplementation.

Clin Exp Reprod Med 2018 Dec 30;45(4):177-182. Epub 2018 Nov 30.

Ajyal IVF Center, Ajyal Hospital, Sohag, Egypt.

Objective: To investigate the effects of myo-inositol (Myo-Ins) supplementation of cryopreserved human semen on the cryo-survival rate (CSR).

Methods: Semen samples were obtained from 41 infertile men. Following routine semen analysis, each sample was divided into two equal aliquots (0. Read More

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December 2018

Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice ().

Clin Exp Reprod Med 2018 Dec 30;45(4):163-169. Epub 2018 Nov 30.

American Center for Reproductive Medicine, Urological Institute, Cleveland Clinic, Cleveland, OH, USA.

Objective: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. Read More

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December 2018

An Unusual Presentation of Lupus Vulgaris and the Practical Usefulness of Dermatoscopy.

Case Rep Dermatol Med 2018 14;2018:1036162. Epub 2018 Nov 14.

Specialist in Dermatology-Venereology, Chief of State Clinic of Dermatology, Hospital for Skin and Venereal Diseases, Delfon 124, 54643 Thessaloniki, Greece.

We report a case report of lupus vulgaris (LV) presented on the extremities of an 80-year-old man. He was misdiagnosed as having psoriasis and referred to our department for a second-opinion evaluation. The discrepancy between the clinical manifestation which was misleading and the dermatoscopic findings raised the suspicion of an underlying granulomatous disease and we proceeded to skin biopsy. Read More

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November 2018
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Novel gene mutation in a patient with Menkes disease.

Appl Clin Genet 2018 22;11:151-155. Epub 2018 Nov 22.

Health Sciences Faculty, Universidad Icesi, Cali, Colombia,

Background: Menkes disease is a congenital neurodegenerative disorder caused by gene mutations. Clinical features include epilepsy, growth delay, reduced muscle strength, skin laxity, abnormal hair, and urologic abnormalities.

Case Presentation: We describe an infant with developmental delay, neurologic degeneration, and kinky hair. Read More

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November 2018
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A 10-point plan for avoiding hyaluronic acid dermal filler-related complications during facial aesthetic procedures and algorithms for management.

Clin Cosmet Investig Dermatol 2018 23;11:603-611. Epub 2018 Nov 23.

Institute of Medical and Biomedical Education, St George's University of London, London, UK.

The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures. Read More

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November 2018
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Author Correction: Transcription start site profiling of 15 anatomical regions of the Macaca mulatta central nervous system.

Sci Data 2018 Dec 11;5(1). Epub 2018 Dec 11.

German Center for Neurodegenerative Diseases, Otfried-Müller Straße 23, Tübingen, 72076, Germany.

The authors regret that Luba M. Pardo was omitted in error from the author list of the original version of this Data Descriptor. This omission has now been corrected in the HTML and PDF versions. Read More

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December 2018

Idiopathic calcinosis cutis of the scrotum: a case report and review of the literature.

J Med Case Rep 2018 Dec 12;12(1):366. Epub 2018 Dec 12.

Department of Dermatology and Venereology, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.

Background: Abnormal deposition of calcium in the skin or subcutaneous tissue is termed calcinosis cutis. Idiopathic calcinosis cutis of the scrotum is an uncommon entity. The pathogenesis of idiopathic calcinosis cutis of the scrotum is debatable. Read More

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December 2018
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Clinical and Pathological Analysis of Two Cases of Cutaneous Malignant Melanoma.

Curr Health Sci J 2015 Jul-Sep;41(3):274-280. Epub 2015 Mar 15.

Pathology dept., Clinical Emergency County Hospital of Craiova.

The purpose of this study was the clinical and histo-immunohistochemical analysis of two cases: a cutaneous pigmented facial malignant melanoma and a lumbar congenital nevus with malignant transformation. A series of clinical elements raised the suspicion of some malignant melanocytic lesions and the histopathological analysis through the paraffin embedding technique confirmed the clinical suspicion. The immunohistochemical analysis using the streptavidin-biotin-peroxydase method of the facial malignant melanoma showed: S100 protein intense and diffuse positive, Tyrosinase diffuse positive, HMB45 strong and focal positive, Cyclin D1 positive in approximately 40% and Ki-67 positive in almost 70% of the tumor cells. Read More

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March 2015
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Large Font Patient Written Instructions.

J Am Acad Dermatol 2018 Dec 8. Epub 2018 Dec 8.

The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160. Electronic address:

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December 2018

The impact of integrin β2 on granulocyte/macrophage progenitor proliferation.

Stem Cells 2018 Dec 11. Epub 2018 Dec 11.

Beijing Key Laboratory od Diabetes Prevention and Research, Endocrinology Center, Lu He hospital, Capital Medical University, Beijing, China.

Rationale: Previously we reported that although the HSPC frequency in bone marrow cells (BMC) was comparable between β2-/- and β2+/+ mice, transplantation of β2-/- BMC into lethally irradiated CD45.1 recipient resulted in more myeloid cell production than β2+/+ BMC.

Objective: To address if integrin β2 deficiency skews granulocyte/macrophage progenitor (GMP) proliferation. Read More

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December 2018
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Pediatric Dermatology - critical approach to the new treatments.

Dermatol Ther 2018 Dec 7:e12801. Epub 2018 Dec 7.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health.

The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. Read More

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December 2018
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Allergic contact dermatitis due to undecylenic acid in an antifungal nail solution.

Contact Dermatitis 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Hospital General Universitario de Alicante. Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

Undecylenic acid (CAS no. 112-38-9) has antifungal and antibacterial effects. For this reason, it is used along with imidazole antifungals. Read More

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December 2018

Erster Fallbericht einer beidseitigen zirkumskripten Morphea des Gesichts.

J Dtsch Dermatol Ges 2018 Dec;16(12):1480-1482

Dermatology, Venereology and Leprosy, Ellahi Medicare Clinic, Kashmir, India.

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December 2018

Faziale Papeln bai follikulärem B-Zell-Lymphom.

J Dtsch Dermatol Ges 2018 Dec;16(12):1493-1495

Department of Dermatology and Venereology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

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December 2018

Rote und juckende bilaterale supraorbitale Schwellungen.

J Dtsch Dermatol Ges 2018 Dec;16(12):1503-1506

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, Deutschland.

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December 2018

Nomenclature of cutaneous vasculitides - German translation of the dermatologic addendum to the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.

J Dtsch Dermatol Ges 2018 Dec;16(12):1425-1432

Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria.

The nomenclature system agreed upon by the Chapel Hill Consensus Conference (CHCC) with respect to the terminology and precise definition of the various types of vasculitis has gained widespread interdisciplinary and international acceptance. As the revised version from 2012 (CHCC 2012) does not address the special features of vasculitis of the skin, it has recently been supplemented with an addendum containing the nomenclature of cutaneous vasculitides (D-CHCC). The present article provides the German translation of the terms and defintions of the D-CHCC as well as additional explanatory comments. Read More

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December 2018
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Patterns of infiltration and local recurrences of various types of cutaneous sarcomas following three-dimensional histology.

J Dtsch Dermatol Ges 2018 Dec;16(12):1434-1442

Department of Dermatology, Eberhardt Karls University, Tübingen Germany.

Background: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure. Read More

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December 2018
2 Reads

Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Service of Dermatology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain.

Background: Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC).

Objective: To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients. Read More

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December 2018
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Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus.

Microbiol Immunol 2018 Dec 11. Epub 2018 Dec 11.

Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.

Trichodysplasia spinulosa associated polyomavirus (TSPyV), a newly identified polyomavirus has been implicated as a causative agent of trychodysplasia spinulosa (TS), a rare proliferative skin disease in severly immunocompromised hosts. The diagnosis using monoclonal antibodies (mAbs) has been provided as a promising tool as it offers high specificity towards specific antigen. Till there is no good mAb available for diagnosis of TS disease. Read More

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December 2018
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