201,480 results match your criteria Dermatology Online Journal [Journal]


Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi.

PLoS Pathog 2018 Dec 6;14(12):e1007353. Epub 2018 Dec 6.

Department of Dermatology, Duke University, Durham, North Carolina, United States of America.

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December 2018
5 Reads

Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins.

Cell Signal 2018 Dec 3. Epub 2018 Dec 3.

Division of Cell Matrix Biology & Regenerative Medicine, UK. Electronic address:

Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of fibrillin microfibrils, a key elastic fibre component, is a hallmark of early photodamage and that these ECM assemblies are susceptible in vitro to physiologically attainable doses of ultraviolet radiation (UVR). Here, we test the hypotheses that UVR-mediated photo-oxidation is the primary driver of fibrillin microfibril and fibronectin degradation and that prior UVR exposure will enhance the subsequent proteolytic activity of UVR-upregulated matrix metalloproteinases (MMPs). Read More

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December 2018
5 Reads

Are environmental factors for atopic eczema in ISAAC Phase Three due to reverse causation?

J Invest Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Department of Paediatrics, Prince of Wales Hospital, Hong Kong, SAR China.

Some previously described environmental associations for atopic eczema (AE) may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple AE risk factors. ISAAC Phase Three surveyed children within schools (the sampling unit) on AE symptoms and potential risk factors. Read More

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December 2018
2 Reads

The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:

The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More

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December 2018
6 Reads

Standardized laboratory monitoring with use of isotretinoin in acne.

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola University Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:

-The optimal timing of laboratory tests for patients on isotretinoin treatment for acne is uncertain.-In this series, although abnormalities in serum lipids in patients receiving isotretinoin were not infrequent, they were mild to moderate, and were generally noted around the second month of treatment.-For healthy patients on isotretinoin, we recommend that a lipid panel and liver function test be performed at baseline and at month 2, when peak dosing is achieved. Read More

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December 2018
2 Reads

Trends of skin cancer mortality after transplantation in the United States: 1987 to 2013.

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola University Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:

- -Organ transplant recipients are at high risk of skin cancer mortality.-This study defines population-based mortality from skin cancer posttransplantation and identifies recipients at increased risk of skin cancer mortality.-These findings can guide dermatologists in adopting skin cancerescreening protocols specific to the identified high- risk categories. Read More

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December 2018
4 Reads

Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: A Danish nationwide population-based cohort study.

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:

•Active cancers and inflammation increase the risk for venous thromboembolism. It is unknown whether this applies to mycosis fungoides and parapsoriasis.•Patients with mycosis fungoides and parapsoriasis have increased risk for venous thromboembolism. Read More

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December 2018
2 Reads

Pemphigus and hematologic malignancies: A population-based study of 11,859 patients.

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola University Medical Center Dermatology, 321 N La Grange Rd, La Grange Park, IL. Electronic address:

•Hematologic malignancies have been reported sporadically in patients with pemphigus.•In the current study, significant associations were observed between pemphigus and chronic leukemia, multiple myeloma, and non-Hodgkin lymphoma.•Further research is needed to confirm these findings in other cohorts. Read More

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December 2018
5 Reads

Rare lesion in the uterine cervix with irregular vaginal bleeding.

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

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December 2018
1 Read

Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013192. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Melanoma accounts for a small proportion of all skin cancer cases but is responsible for most skin cancer-related deaths. Early detection and treatment can improve survival. Smartphone applications are readily accessible and potentially offer an instant risk assessment of the likelihood of malignancy so that the right people seek further medical attention from a clinician for more detailed assessment of the lesion. Read More

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December 2018
4 Reads

African Kaposi's Sarcoma.

Acta Med Port 2018 Nov 30;31(11):697. Epub 2018 Nov 30.

Department of Dermatology. Santa Maria University Hospital. Lisbon. Institute for Hygiene and Tropical Medicine. Universidade NOVA. Lisbon. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

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November 2018
3 Reads

Self-management of chronic skin conditions.

Br J Community Nurs 2018 Dec;23(12):577

Lecturer-Practitioner, Dermatology Education Partnership Ltd.

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December 2018
2 Reads

Fresh/frozen Tübingen technique (Margin strip method) for head and neck basal cell carcinoma: A retrospective study of 298 cases.

Authors:
Roberto Cecchi

Dermatol Ther 2018 Dec 6:e12799. Epub 2018 Dec 6.

Department of Dermatology, San Jacopo Hospital, V. Ciliegiole 1, 51100 Pistoia, Italy.

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December 2018

The Prevalence of Atopic Dermatitis and Chronic Spontaneous Urticaria are Associated with Parental Socioeconomic Status in Adolescents in China.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Xiangya Hospital, 410008 Changsha, China.

The association of atopic dermatitis and chronic spontaneous urticaria with socioeconomic status has been little studied. The aim of this study was to investigate the prevalence of skin diseases and their association with socioeconomic status in adolescents in China. A cross-sectional study was conducted at a comprehensive university. Read More

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December 2018
3 Reads

Out-of-pocket Costs for Individuals with Atopic Eczema: A Cross-sectional Study in Nine European Countries.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology and Allergy, Technical University Munich, Biedersteinerstrasse 29, DE-80802 Munich, Germany.

Atopic eczema (AE) is one of the most common non-communicable inflammatory skin diseases, and has a huge socioeconomic impact. Studies on the everyday economic impact of AE on patients, however, are limited. To estimate the annual extra out-of-pocket spending due to AE among patients in Europe, a cross-sectional study using computer-assisted phone interviewing of patients with AE was performed in 9 European countries. Read More

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December 2018
3 Reads

Anetoderma and Systemic Lupus Erythematosus: Case Report and Literature Review.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Pontevedra University Hospital, EOXI Pontevedra-Salnés, Centro de Especialidades Mollavao, c/ Simón Bolívar s/n., ES-36001 Pontevedra, Spain.

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December 2018
1 Read

Association of Vulvar Melanoma with Lichen Sclerosus.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Turku University Hospital, PO Box 52, FIN-20521 Turku, Finland.

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December 2018
1 Read

Use of Systemic Treatment in Patients with Chronic Pruritus: A Survey of Dermatologists in the Netherlands.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Radboud university medical center, 6500HB Nijmegen, The Netherlands.

Treatment of chronic pruritus can be a challenge for clinicians. Several systemic treatments have been suggested to reduce itch, such as gabapentinoids and antidepressants. The aim of this study was to assess the current practice of dermatologists regarding systemic treatment in patients with chronic pruritus, and to identify possible barriers in the prescription of these treatments. Read More

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December 2018
4 Reads

Massive Localized Lymphedema, an Emerging Problem and a Challenging Pseudosarcomatous Condition Mimicking Liposarcoma.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, University of Colorado Denver School of Medicine, 80206 Denver, USA.

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December 2018
1 Read

Painless Horny Keratotic Spines on the Palms: A Quiz.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology and Venereology, Geneva University Hospitals, 1205 Geneva, Switzerland.

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December 2018
1 Read

Unilateral Eyelid Plaque Leading to Diagnosis of Systemic Lupus Erythematosus.

J Clin Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

From the Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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December 2018

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

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December 2018
3 Reads

Epithelioid angiosarcoma arising from a frontoparietal arteriovenous malformation.

J Dtsch Dermatol Ges 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Venereology and Allergology, Leipzig University Medical Center, Leipzig, Germany.

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December 2018
1 Read

Systemic therapies of pityriasis rubra pilaris: a systematic review.

J Dtsch Dermatol Ges 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Venereology, and Allergology, University Medical Centre, Göttingen, Germany.

Pityriasis rubra pilaris (PRP) is a rare papulosquamous disorder. Treatment is challenging; the armamentarium consists of topical corticosteroids, phototherapy, classic systemic treatments such as retinoids or immunosuppressive drugs, and most recently biologicals. However, the relative effectiveness of therapies is unclear. Read More

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December 2018

Epidermolytic ichthyosis due to a de novo missense mutation c.1307T> C; p.Leu436Pro in KRT10.

J Dtsch Dermatol Ges 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Carl Gustav Carus University Medical Center, Dresden Technical University, Dresden, Germany.

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December 2018
1 Read

CD8-positive lymphomatoid papulosis (type D): Some lesions may lack CD30 expression and overlap histologically with mycosis fungoides.

Int J Dermatol 2018 Dec 6. Epub 2018 Dec 6.

School of Medicine, Indiana University, Indianapolis, IN, USA.

Background: CD8 lymphomatoid papulosis is frequently indistinguishable histopathologically from primary cutaneous aggressive epidermotropic CD8 T-cell lymphoma except for the expression of CD30. However, absent or weak expression of CD30 has been rarely reported in cases of CD8 LyP.

Objective: We aim to study the clinical and pathologic features of cases of CD8 LyP with no or minimal expression of CD30. Read More

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December 2018

Dermoscopy of cutaneous smooth muscle neoplasms: a morphological study of 136 cases.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Department. Hospital, Universitario de Alicante. ISABIAL. Miguel Hernandez University. Sant Joan de Alicante, Spain.

Background: A variety of cutaneous smooth muscle neoplasms may arise in the skin and are frequently unrecognized by clinicians. There is sparse data relating to the dermoscopy of piloleiomyiomas (PL) and nothing has been published about the dermoscopy of angioleiomyomas (AL) and leiomyosarcomas (LS).

Objectives: To evaluate the morphological findings of a large series of cutaneous PL, AL and LS under dermoscopic observation, comparing these findings among them. Read More

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December 2018
3 Reads

A new approach to lower eyelid-cheek junction rejuvenation.

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Beijing Lomeye Cosmetic Surgery Clinic, Beijing, China.

Background: Anti-aging in lower eyelid-cheek junction area has always been the upmost widely sought of cosmetic surgery. Removal of orbital fat from inside or outside, removal of part of the skin or even the orbicularis muscle, superficial pull and deep fill and a series of surgical procedures like these have been or are becoming the mainstream of clinical practice. However, aging involves a variety of tissues and causes, which is a dynamic and continuous process. Read More

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December 2018
1 Read

Irritative potency of selected wound antiseptics in the hen's egg test on chorioallantoic membrane to predict their compatibility to wounds.

Wound Repair Regen 2018 Dec 5. Epub 2018 Dec 5.

Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany.

Antiseptics are being used for prevention of infections in acute wounds and for treatment of infections in acute and chronic wounds. However, some antiseptics' high tissue toxicity might delay the healing process. The aim of this study was to investigate the tissue toxicity of preferentially used wound antiseptics and the influence of antiphlogistic additives via the hen's egg test on the chorioallantoic membrane (HET-CAM). Read More

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December 2018
2 Reads

Non-genetic and genetic predictors of a superficial first basal cell carcinoma.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: several observational studies have suggested differences in the risk factor profile between patients with superficial basal cell carcinomas (BCCs) and non-superficial BCCs.

Objective: to test the reproducibility of previous study findings and to find new genetic and non-genetic predictors for patients with a superficial first BCC.

Methods: 14. Read More

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December 2018
2 Reads

Dermoscopic evaluation of melanocytic nevi changes after photoepilation techniques: a prospective study.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Clinic - Department of Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.

Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known.

Objective: Prospective study on clinical and dermatoscopic effects of photoepilation on melanocytic nevi.

Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up program from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Read More

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December 2018

Work-related skin diseases of Santa Claus.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Dermatology Department, Allergology, and Venereology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

The health of Santa Claus (SC) and work-related risks have been discussed on very few occasions in the medical literature [1,2]. We believe that due to his unique line of work, the skin of SC is peculiarly at risk and SC may be exposed to various work-related cutaneous hazards (table 1). According to Finnish folklore, SC currently lives and mainly work during the year in Korvatunturi (literally "Ear fell") in Finnish Lapland [3]. Read More

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December 2018
2 Reads

Preliminary experience of the use of high-resolution skin ultrasound for the evaluation of extrathyroideal manifestations of Graves' disease and response to UVA-1 phototherapy.

Photodermatol Photoimmunol Photomed 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Unit, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Siena, Italy.

Graves' orbitopathy (GO) and pre-tibial mixedema (PTM) are autoimmune manifestation sharing the same etiology and histopathology, a chronic course and a frustrating treatment. Current management include topical and systemic corticosteroid as first line therapy, whereas cyclosporine, surgery and orbital radiotherapy are indicated for severe GO with variable results and mostly temporary remissions. In particular, keratopath and photophobia, due to exophthalmos and eyelid retraction, impaired eye mobility and diplopia due to the compression of optic nerve and extra-ocular muscles are usually minimally modified, as well as leg plaques/nodules and lymphoedema. Read More

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December 2018
3 Reads

Unexpected photosensitivity - a patient with dermatomyositis and concomitant solar urticaria.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Dept. of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany.

Dermatomyositis (DM) is a connective tissue disease with rare incidence, characterized by progressive muscle weakness and typical cutaneous manifestations. Its pathogenesis is still incompletely understood, but next to genetic predisposition environmental factors seem to be implicated in the development of DM (1). Photosensitivity is one important factor for the onset and exacerbation of DM, which is corroborated by the distribution of the cutaneous features on sun-exposed areas and disease photoaggravation (2,3). Read More

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December 2018

Prevalence and persistence of oral HPV infection in Italy.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

DISSAL, Section of Dermatology, Ospedale Policlinico San Martino, Largo Rosanna Benzi, 10, 16132, Genoa, Italy.

Oral human papillomavirus (HPV) persistent infection may cause numerous tumors but little is known about the HPV clearance time and the variables that may influence the HPV persistence . We aimed to assess the prevalence of the oral HPV infection, the HPV persistence rate and the variables influencing the persistence. This article is protected by copyright. Read More

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December 2018

Regrets after tattooing and tattoo removal in the general population of France.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

FIMARAD, Hopital Necker Enfants Malades, Paris, France.

The market of tattoo removal is constantly rising [1]. Recent American polls showed a growing proportion of tattooed individuals that regretted getting tattooed: nearly one fourth (23%) in 2016 against 14% in 2012 [2]. In France, a recent poll in 2016 in France showed that 7% of the tattooed individuals had a tattoo removed [3]. Read More

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December 2018
3 Reads

Solar Angioedema: A report of a patient and a review of literature.

Photodermatol Photoimmunol Photomed 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.

Solar angioedema is a rare photodermatosis, with only 11 reported patients worldwide. Patients develop facial (predominately eyelids, lips) and/or acral swelling hours after sun exposure, especially while on vacation to tropical areas. Management includes photoprotection and sun avoidance; preemptive antihistamines have been tried with minimal effect. Read More

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December 2018
1 Read

Itch relief in patients with psoriasis: effectiveness of calcipotriol plus betamethasone dipropionate foam.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Comprehensive Center for Inflammation Medicine, University of Luebeck, Luebeck, Germany.

Background: Itch is common in psoriasis, adversely affecting health-related quality of life (HRQoL) and sleep.

Objective: We evaluated the efficacy of topical fixed-dose combination calcipotriol 50 μg/g plus betamethasone dipropionate 0.5 mg/g cutaneous foam (Cal/BD foam) on itch, itch-related sleep loss and HRQoL versus foam vehicle. Read More

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December 2018

A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Background: Trappin-2/pre-elafin is an endogenous inhibitor of human neutrophil elastase involved in inflammation, innate immunity and vascular remodeling, which consist of the complex pathological process of systemic sclerosis (SSc).

Objectives: To clarify the potential role of trappin-2 in SSc.

Methods: Serum trappin-2 levels were determined by enzyme-linked immunosorbent assay in 51 SSc and 18 healthy subjects. Read More

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December 2018
1 Read

Methotrexate in atopic eczema - Reply to a letter.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Department Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany and, Christine Kühne-Center for Allergy Research and Education (CK-CARE)Davos.

Goujon et al. submit a letter-type manuscript to JEADV (1), as a comment to the recently published European consensus-based S2k guidelines or treatment of atopic eczema (2,3). The assigned writing subgroups for each topic were encouraged to include the 'best available evidence' for all chapters of the guideline (2). Read More

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December 2018
2 Reads

Letter to the Editor: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. JEADV 2018, 32, 850-878. doi.org/10.1111/jdv.14888.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Head Research & Head Outpatient Clinic, Department of Dermatology, University Hospital Zürich, Switzerland.

We read with interest and with full consent the new consensus-based European guidelines for the treatment of atopic eczema, Part II . However, we would like to comment on the section on microbial textiles where the recommendation to use silk garments with permanent antimicrobial in the management of children with moderate to severe eczema is raised. On the basis of an UK multicenter clinical trial which seemed to show that silk garments with permanent antimicrobial were ineffective in the treatment of children with atopic eczema, the guidelines deny now any clinical benefit of AEGIS-coated silk textiles in children with atopic eczema and this contrary to the previous two guidelines . Read More

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December 2018
2 Reads

Optimization strategies for HIV, hepatitis and syphilis testing in Infectious Disease Clinic and Dermatology Unit of Modena: seven-years results of collaboration experience.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.

Background: Screening tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis infections performed in at-risk population show a higher number of positive tests compared to those carried out in the general population. "Test & Counselling" Ambulatory of Infectious Disease Clinic (T&C-IDC) and Sexually Transmitted Diseases Ambulatory of Dermatology Unit (STDs-DU) of Modena began collaboration in 2010 and adopted a common diagnostic serological profile since 2013.

Objectives: The main objective was to analyse the number of screening tests performed in the T&C-IDC and STDs-DU, comparing the results obtained after the adoption of the shared protocol with the previous period. Read More

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December 2018

Rebound effect associated with JAK inhibitor use in the treatment of alopecia areata.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Tufts Medical Center, Boston, MA.

Alopecia areata (AA) is a common autoimmune disease driven by Th1 cytokines characterized by non-scarring hair loss. Mouse models have demonstrated that IFN-γ-producing NKG2D+ CD8+ cytotoxic T lymphocytes (CTLs) are essential for disease pathogenesis, along with JAK-STAT dependent cytokines IFN-γ and IL-15, which induce autoreactive T cell activation. This article is protected by copyright. Read More

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December 2018
1 Read

Effects of red light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects.

Photodermatol Photoimmunol Photomed 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Radboud University Medical Center, René Descarstesdreef 1, 6500 HB, Nijmegen, The Netherlands.

In an original article recently published in Photodermatology, Photoimmunology and Photomedicine (1), we aimed to prove therapeutic effects of photobiomodulation (PBM) based on clinical outcomes by investigating the impact of UV-free blue light at 453 nm on the recovery of the skin barrier and on the cutaneous inflammatory response elicited by acute perturbation of the skin of healthy human volunteers. In this Letter we describe a study of same design and scope in which we investigated the impact of LED red light at 656 nm. Briefly, tape stripping and histamine iontophoresis were performed on the forearm of 22 healthy volunteers in two consecutive weeks: in one week, challenges were followed by irradiation with red light at 656 nm, in the other week (control), no light was administered. Read More

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December 2018
2 Reads

Brentuximab induced CD30+ cutaneous lymphoma responded to anti-PD1 treatment.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Department, Cutaneous Lymphoma Clinic, National& Kapodestrian University of Athens, Medical School, "A. Sygros" Hospital for skin diseases, Athens, Greece.

Over the last decade major efforts have been made for the optimization of immune-directed therapies against cancer. Regarding cutaneous lymphomas (CTCLs), brentuximab (BV) has been recently approved by FDA and EMA for the treatment of primary cutaneous anaplastic large cell lymphoma as well as CD30-expressing mycosis fungoides, based on the ALCANZA trial favorable results. Concurrently, immune checkpoint inhibition has been shown to be of great value in the treatment of solid tumors and with promising results in a range of hematologic malignancies, however relevant data concerning CTCLs' treatment remain inconclusive. Read More

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December 2018
1 Read

Reply to a correspondence addressing the European guideline for treatment of atopic eczema, functional textiles and the CLOTHES trial.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Department Dermatology and Allergy Biederstein, Technische Universität München Munich, Germany and Christine Kühne-Center for Allergy Research and Education (CK-CARE)Davos.

We have read with interest the respectfully written correspondence by Wüthrich et al. regarding antimicrobial silk textiles for atopic dermatitis (AD) (1). Though it was submitted as a comment to the European consensus-based S2k guidelines on treatment of atopic eczema (2,3), it is discussing in 70% of its length the CLOTHES trial - published in two non-JEADV-publications which we have neither designed nor authored (4,5). Read More

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December 2018
2 Reads

Long noncoding RNA HAND2-AS1 inhibits cancer cell proliferation, migration, and invasion in esophagus squamous cell carcinoma by regulating microRNA-21.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.

Long noncoding RNA (lncRNA) HAND2-AS1 is a well-characterized tumor suppressor in several types of malignancies, while its role in esophagus squamous cell carcinoma (ESCC) is unknown. In this study, we found that lncRNA HAND2-AS1 was downregulated, while microRNA-21 ( miRNA-21) was upregulated in tumor tissues than in adjacent healthy tissues of ESCC patients. Expression levels of lncRNA HAND2-AS1 and miRNA-21 were significantly and inversely correlated in tumor tissues but not in healthy tissues. Read More

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December 2018