205,116 results match your criteria Dermatology Basel Switzerland[Journal]


Drug Discovery for Pemphigoid Diseases.

Curr Protoc Pharmacol 2019 Feb 20:e55. Epub 2019 Feb 20.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigoid diseases (PDs) are a group of autoimmune bullous diseases characterized and caused by autoantibodies targeting structural proteins of the skin and mucous membranes. Chronic inflammation, subepidermal blistering, and often scaring are the clinical characteristics of PDs. Itching and, in severe cases, disabilities resulting from scaring (i. Read More

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http://dx.doi.org/10.1002/cpph.55DOI Listing
February 2019

Crowdsourcing to delineate skin affected by chronic graft-vs-host disease.

Skin Res Technol 2019 Feb 20. Epub 2019 Feb 20.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Estimating the extent of affected skin is an important unmet clinical need both for research and practical management in many diseases. In particular, cutaneous burden of chronic graft-vs-host disease (cGVHD) is a primary outcome in many trials. Despite advances in artificial intelligence and 3D photography, progress toward reliable automated techniques is hindered by limited expert time to delineate cGVHD patient images. Read More

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http://dx.doi.org/10.1111/srt.12688DOI Listing
February 2019

Interleukin-17 receptor A blockade with brodalumab in palmoplantar pustular psoriasis: Report on four cases.

J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Venereology and Allergology, University Clinic Göttingen, Göttingen, Germany.

Palmoplantar pustular psoriasis, also termed palmoplantar pustulosis (PPP), is a rare disease affecting the palmoplantar regions characterized by sterile, yellow to brown pustules mostly on erythematous skin. PPP is related to a high burden due to painful, impaired and stigmatizing character. Several isoforms of interleukin (IL) have been implicated in its pathophysiology. Read More

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http://dx.doi.org/10.1111/1346-8138.14815DOI Listing
February 2019

Not only a Hollywood trend: The dermatologic features of villains in classic and contemporary literature.

Br J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Dermatology Department, University General Hospital of Patras, Greece.

A disproportional number of movie villains have skin dosorders . However, it is not only in Hollywood that this is over-represented, it is seen in other forms of art and human expression, including classic and contemporary literature. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/bjd.17782DOI Listing
February 2019

Anticipating the Era of Dermatology Disease Trackers.

Br J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

University of Arizona, Department of Medicine, Division of Dermatology, Tucson, AZ, USA.

The current era of patient-centered medicine is characterized by widespread accessibility to medical information and self-driven involvement in disease management. This movement is evident in the rapid expansion of medical mobile applications (apps) for personal electronic devices. Between 2014 and 2017, dermatology-specific mobile apps increased by 81% from 291 to 526, with a growing selection of disease tracking apps for various dermatologic conditions. Read More

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http://dx.doi.org/10.1111/bjd.17635DOI Listing
February 2019

FEMALE PATTERN HAIR LOSS AND ANDROGEN EXCESS: A REPORT FROM THE MULTIDISCIPLINARY ANDROGEN EXCESS AND PCOS COMMITTEE.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology and Medicine, Duke University Medical Center, Durham, NC, USA.

Objective: To determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female pattern hair loss (FPHL), a common form of hair loss in women that is characterized by the reduction of hair density in the central area of the scalp, while the frontal hairline is generally well conserved.

Participants: An expert task force appointed by Androgen Excess and PPCOS society, which included specialists from dermatology, endocrinology, and reproductive endocrinology.

Evidence: Levels of evidence were assessed and graded from A to D. Read More

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http://dx.doi.org/10.1210/jc.2018-02548DOI Listing
February 2019

Metabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma.

PLoS One 2019 20;14(2):e0211679. Epub 2019 Feb 20.

Training Center of the European Academy of Andrology (EAA), Dermatology, Venerology and Allergology Clinic, University Hospital Leipzig, Leipzig, Germany.

In 50% of all infertility cases, the male is subfertile or infertile, however, the underlying mechanisms are often unknown. Even when assisted reproductive procedures such as in vitro fertilization and intracytoplasmic sperm injection are performed, the causes of male factor infertility frequently remain elusive. Since the overall activity of cells is closely linked to their metabolic capacity, we analyzed a panel of 180 metabolites in human sperm and seminal plasma and elucidated their associations with spermiogram parameters. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211679PLOS
February 2019

Dermatologic Urgencies and Emergencies: What Every Pathologist Should Know.

Arch Pathol Lab Med 2019 Feb 20. Epub 2019 Feb 20.

From the Department of Dermatology, Saint Louis University, St Louis, Missouri (Dr Abate);the Departments of Dermatology (Dr Battle),and Pathology (Drs Gardner and Shalin),University of Arkansas for Medical Sciences, Little Rock; and the Department of Dermatology, University of Mississippi Medical Center, Jackson (Dr Emerson).

Context.—: Fatal dermatologic diseases and ones with high morbidity can occur in the inpatient setting. In such cases, prompt and accurate assessment of a bedside skin biopsy is required. Read More

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http://dx.doi.org/10.5858/arpa.2018-0239-RADOI Listing
February 2019

Matrical Carcinoma with Melanocytic Hyperplasia Mimicking Nodular Melanoma in an Elderly Mexican Male.

J Cutan Pathol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, University of California, Irvine.

Matrical carcinoma with melanocytic hyperplasia (MCMH), previously referred to as malignant melanocytic matricoma, is a rare variant of the uncommon pilomatrical carcinoma, which occurs most often on the head/neck and upper backs of middle-aged men. Nodular lesions may resemble pigmented basal cell carcinoma or melanoma clinically. We present a case of MCMH in a Hispanic patient with history of melanoma. Read More

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http://dx.doi.org/10.1111/cup.13445DOI Listing
February 2019

Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Importance: Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes.

Objective: To evaluate the epidemiologic characteristics, clinical features, and disease associations of NL in patients with or without type 1 or 2 diabetes. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.5635DOI Listing
February 2019

Association of Atherosclerosis Prevalence With Age, Race, and Traditional Risk Factors in Patients With Psoriasis.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamadermatol.2018.5462DOI Listing
February 2019

Yellow Periorbital Plaque and Retroperitoneal Fibrosis.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1001/jamadermatol.2018.5233DOI Listing
February 2019

Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Harvard Medical School, Boston, Massachusetts.

Importance: Extramammary Paget disease (EMPD), a rare intraepithelial adenocarcinoma, poses a therapeutic challenge with high postoperative recurrence rates and a limited number of effective local treatment options.

Objective: To describe the use and efficacy of a topical combination of fluorouracil and calcipotriene as a palliative therapy for refractory EMPD.

Design, Setting, And Participants: This retrospective case series of 3 women with recurrent, refractory EMPD was conducted at Beth Israel Deaconess Medical Center, Boston, Massachusetts and Washington University School of Medicine, St Louis, Missouri. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4793DOI Listing
February 2019

Reading of the Mitsuda test: comparison between diameter and total area by means of a computerized method.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e5. Epub 2019 Feb 14.

Universidade Federal de Minas Gerais, Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Belo Horizonte, Minas Gerais, Brazil.

The Mitsuda test is a skin test based on the individual's immune response through late and highly specific hypersensitivity reaction to the Mycobacterium leprae bacillus. A negative reaction identifies individuals who present a higher risk of becoming ill if exposed to M. leprae and, if they become ill, to develop the virchowian form of disease. Read More

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http://dx.doi.org/10.1590/S1678-9946201961005DOI Listing
February 2019

De novo histoid leprosy in a Colombian patient with multiple skin nodules on the ears and extremities.

Rev Soc Bras Med Trop 2019 Feb 14;52:e20160502. Epub 2019 Feb 14.

School of Medicine, Universidad del Valle, Cali, Colombia.

Histoid leprosy is an uncommon form of lepromatous leprosy with distinct clinical, histopathological, immunological, and bacteriological features. This variant usually occurs in multibacillary patients who have irregular or inadequate treatment. Herein, we report a case of de novo histoid leprosy diagnosed in a patient from Cali, Colombia. Read More

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http://dx.doi.org/10.1590/0037-8682-0502-2016DOI Listing
February 2019

A review of dupilumab in the treatment of atopic diseases.

Hum Vaccin Immunother 2019 Feb 20. Epub 2019 Feb 20.

a Department of Dermatology , University of California, San Francisco , San Francisco.

Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important drivers of atopic diseases. In March of 2017, the United States Food and Drug Administration (FDA) approved dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults that is uncontrolled with topical medications, becoming the first biologic agent approved to treat this chronic skin condition. In October of 2018, Dupilumab received approval by the FDA as an add-on maintenance therapy in patients with moderate-to-severe asthma aged 12 years or older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma. Read More

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http://dx.doi.org/10.1080/21645515.2019.1582403DOI Listing
February 2019

Fine mapping and subphenotyping implicates ADRA1B gene variants in psoriasis susceptibility in a Chinese population.

Epigenomics 2019 Feb 20. Epub 2019 Feb 20.

HumanBiology, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.

Aim: A genomic region on 5q33.3 lies between and encompasses the IL12B and PTTG1 genes, and contains many potential psoriasis causal variants. We aimed to further examine the influence of variants in and around this region. Read More

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http://dx.doi.org/10.2217/epi-2018-0131DOI Listing
February 2019

Melanocyte spheroids are formed by repetitive long-term trypsinization.

Indian J Dermatol Venereol Leprol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, The First Affiliated Hospital of Bengbu Medical College, Anhui, China.

Background: Autologous melanocyte transplantation plays an important role in the treatment of vitiligo.

Objective: Previous studies have indicated that, compared with melanocytes growing in monolayers, melanocyte spheroids have a better survival in growth factor- and serum-deprived conditions.

Methods: Melanocyte spheroids were obtained from human epidermis by repetitive long-term trypsinization and maintained an aggregated morphology for a short period in certain conditions. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_275_17DOI Listing
February 2019

Lichenoid skin lesions: A rare manifestation in secondary syphilis.

Indian J Dermatol Venereol Leprol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Chile Clinical Hospital, Santiago, Chile.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_200_18DOI Listing
February 2019

Pseudoxanthomatous or xanthelasmoid mastocytosis: Reporting a rare entity.

Indian J Dermatol Venereol Leprol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India.

Mastocytosis is a disease characterized by abnormal and pathologic increase in mast cells in the cutaneous tissue and extracutaneous organs such as the bone marrow, liver, spleen, lymph node and gastrointestinal tract. Cutaneous mastocytosis comprises of four major clinical variants: solitary and multiple mastocytomas, urticaria pigmentosa, diffuse cutaneous mastocytosis and telangiectasia macularis eruptiva perstans. Cutaneous mastocytosis of the xanthelasmoid type is a rare variant of diffuse mastocytosis. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_633_17DOI Listing
February 2019

Prevalence of Severe Atopic Dermatitis in Adults and Children in a Health Area of Madrid, Spain.

J Investig Allergol Clin Immunol 2019 Feb;29(1):77-79

Allergy Department, University Hospital Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0339DOI Listing
February 2019

Systemic Autoimmunity in a Patient With CANDLE Syndrome.

J Investig Allergol Clin Immunol 2019 Feb;29(1):75-76

Immunodeficiencies Research Unit, National Institute of Pediatrics, Mexico City, Mexico.

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http://dx.doi.org/10.18176/jiaci.0338DOI Listing
February 2019

Report of a Case of IgE-Mediated Anaphylaxis to Fenugreek.

J Investig Allergol Clin Immunol 2019 Feb;29(1):56-58

Department of Dermatology, Venereology and Allergology, Universität Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.18176/jiaci.0328DOI Listing
February 2019

Successful treatment of psoriasis induced by immune checkpoint inhibitors with apremilast.

Eur J Cancer 2019 Feb 18;110:107-109. Epub 2019 Feb 18.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1016/j.ejca.2019.01.010DOI Listing
February 2019

The Case | Posttransplant upper limb inflammatory nodules.

Kidney Int 2019 Mar;95(3):721-722

Department of Kidney Transplantation, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, RTRS "Centaure," Paris, France.

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http://dx.doi.org/10.1016/j.kint.2018.10.012DOI Listing

Live or Let Die: T Cell Survival in Cancer Immunotherapy.

Immunity 2019 Feb;50(2):280-282

Laboratory of Experimental Dermatology, Department of Dermatology, Otto-von-Guericke University, Magdeburg, Germany. Electronic address:

Combination immune checkpoint blockade targeting CTLA-4 and PD-1 is thought to reinvigorate exhausted T cells better than monotherapies. In this issue of Immunity, Pai et al. (2019) show that, in the setting of low tumor burden, this combination regimen promotes interferon-γ-dependent T cell hyperactivation and death and thus favors tumor progression. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.01.016DOI Listing
February 2019

Study on the psychological health and related risk factors in 245 patients with psoriasis in Inner Mongolia.

Psychol Health Med 2019 Feb 20:1-12. Epub 2019 Feb 20.

a Department of Dermatology , Nanfang Hospital of Southern Medical University , Guangdong , China.

To investigate the psychological health and related risk factors in patients suffering from psoriasis. A total of 245 inpatients and outpatients with psoriasis were selected from January 2014 to December 2015. Patients with psoriasis were assessed a homemade questionnaire as well as the Psoriasis Area and Severity Index (PASI), Selfrating Anxiety Scale, Self-rating Depression Scale, Trait Coping Style Questionnaire and Social Avoidance and Distress Scale. Read More

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http://dx.doi.org/10.1080/13548506.2019.1574352DOI Listing
February 2019

The association between neurological diseases, malignancies and cardiovascular comorbidities among patients with bullous pemphigoid: Case-control study in a specialized Polish center.

Adv Clin Exp Med 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology and Immunodermatology, Medical University of Warsaw, Poland.

Background: Bullous pemphigoid (BP) is the most common autoimmune bullous disease associated with higher mortality and coexisting comorbidities. The strongest relationship has been reported with neurological diseases (NDs) but the particular type of ND differed depending on the study. There are some doubts on the prevalence of other comorbidities. Read More

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http://dx.doi.org/10.17219/acem/90922DOI Listing
February 2019

Methylation and expression analysis of mismatch repair genes in extramammary Paget's disease.

J Eur Acad Dermatol Venereol 2019 Feb 19. Epub 2019 Feb 19.

Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China.

Background: Extramammary Paget's disease (EMPD) is a rare skin cancer with relative high frequencies of germline and somatic mismatch repair (MMR) genes mutations. However, the methylation and expression of these genes have not been validated in EMPD.

Objective: This study aims to confirm the methylation and expression of MMR genes in EMPD. Read More

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http://dx.doi.org/10.1111/jdv.15404DOI Listing
February 2019

Establishing and Developing a Teenage and Young Adult Dermatology Clinic with Embedded Specialist Psychological Support.

Clin Exp Dermatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Dermatology, Churchill Hospital, Old Road, Oxford, OX3 7LE, UK.

Skin conditions are common in adolescence and impart considerable psychological burden. The Department of Health has identified the specialised needs of adolescents transitioning from paediatric to adult services as a priority, yet there are few dedicated transitional clinics in the UK providing appropriate psychosocial support. We have established a monthly Teenage and Young Adult (TYA) clinic dedicated to managing teenagers and young adults with skin disease alongside open-access psychological support. Read More

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http://dx.doi.org/10.1111/ced.13950DOI Listing
February 2019

The Dexcom glucose monitoring system - an isobornyl acrylate free alternative for Diabetes patients.

Contact Dermatitis 2019 Feb 19. Epub 2019 Feb 19.

Department of Conservative Dentistry and Periodontology, University Hospital, LMU Munich, Germany.

Background: Glucose monitoring systems, eg Freestyle Libre (Abott) and Dexcom (Nintamed) more and more replace conventional blood sugar measurement. However, many patients experienced adverse skin reactions such as severe allergic contact dermatitis (ACD). Finally, in August 2017 the culprit allergen in Freestyle Libre, isobornyl acrylate (IBOA), was identified. Read More

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http://dx.doi.org/10.1111/cod.13248DOI Listing
February 2019

Immune Checkpoint Inhibitors and Beyond: An Overview of Immune-Based Therapies in Merkel Cell Carcinoma.

Authors:
Mahtab Samimi

Am J Clin Dermatol 2019 Feb 19. Epub 2019 Feb 19.

Dermatology Department, University Hospital of Tours, Avenue de la République, 37170, Chambray-les-Tours, France.

Merkel cell carcinoma (MCC) is an aggressive skin cancer. Until 2017, patients with advanced disease were typically treated with conventional chemotherapies, with a median response duration of 3 months. Increased evidence of the role of the immune system in controlling this cancer has paved the way for immune-based therapies, with programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) inhibitors at the frontline. Read More

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http://dx.doi.org/10.1007/s40257-019-00427-9DOI Listing
February 2019

AAV-Mediated Gene Delivery to the Spinal Cord by Intrathecal Injection.

Methods Mol Biol 2019 ;1950:199-207

Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.

Gene therapy targeting the spinal cord is an important tool for analyzing mechanisms of nervous system diseases and the development of gene therapies. Analogous to a lumbar puncture in humans, the rodent spinal cord can be accessed through an efficient, noninvasive injection. Here we describe a method for AAV-mediated gene transfer to cells of the spinal cord by intrathecal injection of small quantities of AAV vector. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_11DOI Listing
January 2019

Effect of total glucosides of paeony on the changes of IL-4 and ICAM-1 levels in eczema mouse model serum.

Exp Ther Med 2019 Mar 20;17(3):1545-1550. Epub 2018 Dec 20.

Department of Dermatology, The People's Hospital of Danyang, Zhenjiang, Jiangsu 212300, P.R. China.

Effect of total glucosides of paeony on the changes of IL-4 and ICAM-1 levels in eczema mouse model serum was investigated. A total of 38 KM mice of SPF grade were divided into 3 groups: the control group (n=10), the model group (n=15) and the treatment group (n=13). The pathological model of chronic eczema in mouse right ear was induced using dinitrochlorobenzene acetone solution. Read More

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http://dx.doi.org/10.3892/etm.2018.7122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364213PMC

miR-181b-5p promotes proliferation and inhibits apoptosis of hypertrophic scar fibroblasts through regulating the MEK/ERK/p21 pathway.

Exp Ther Med 2019 Mar 7;17(3):1537-1544. Epub 2019 Jan 7.

Department of Medicine, Eastern Liaoning University, Dandong, Liaoning 118003, P.R. China.

Hypertrophic scar (HS) is a common skin disorder occurring during the wound healing process, and the pathogenesis of HS remains unclear. Previous studies indicated that miRNAs may be involved in the onset and progression of HS. In the present study, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting were used to investigate the expression of miR-181b-5p and decorin in HS tissues. Read More

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http://dx.doi.org/10.3892/etm.2019.7159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364240PMC

A Case of Idiopathic Hemihypertrophy with Hemihypertrichosis.

Int J Trichology 2018 Nov-Dec;10(6):292-293

Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.

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http://www.ijtrichology.com/text.asp?2018/10/6/292/251421
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http://dx.doi.org/10.4103/ijt.ijt_55_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369641PMC
February 2019
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Congenital Triangular Alopecia: A Brief Report.

Int J Trichology 2018 Nov-Dec;10(6):290-291

Department of Dermatology, The Third Hospital of Soochow University, Changzhou, Jiangsu 213003, China.

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http://dx.doi.org/10.4103/ijt.ijt_68_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369636PMC
February 2019

Plucking, Picking, and Pulling: The Hair-Raising History of Trichotillomania.

Int J Trichology 2018 Nov-Dec;10(6):289-290

Department of Dermatology, Wrexham Maelor Hospital, Wrexham, UK.

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http://dx.doi.org/10.4103/ijt.ijt_69_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369640PMC
February 2019

Suspected Herpes Zoster-associated Encephalitis during Treatment with Oral Tofacitinib in Alopecia Universalis.

Int J Trichology 2018 Nov-Dec;10(6):286-288

Department of Dermatology, University of California, Irvine, California, USA.

Systemic administration of Janus kinase inhibitors (JAKis) is associated with adverse events, including serious infections, malignancy, and herpes zoster (HZ). Herein, we report a case of a 17-year-old male with alopecia universalis who developed suspected HZ-associated encephalitis (HZAE) during treatment with oral tofacitinib. Oral tofacitinib was immediately discontinued, and the patient was started on antiviral treatment. Read More

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http://dx.doi.org/10.4103/ijt.ijt_87_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369645PMC
February 2019

New-Onset Androgenic Alopecia following Human Chorionic Gonadotropic Diet and Testosterone Pellet Implantation.

Int J Trichology 2018 Nov-Dec;10(6):284-285

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

A diet involving human chorionic gonadotropic (hCG) injections combined with extreme caloric restriction is sometimes undertaken by people desiring rapid weight loss. We report a patient with new-onset androgenic alopecia following hCG diet combined with the implantation of testosterone pellets. Read More

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http://dx.doi.org/10.4103/ijt.ijt_75_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369644PMC
February 2019

Relationship between Trace Elements and Premature Hair Graying.

Int J Trichology 2018 Nov-Dec;10(6):278-283

Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Context: Hair is said to gray prematurely when a minimum of five gray hairs occurs before the age of 20 in fair skinned, 25 in Asians, and 30 in Africans. It may be genetically associated with autoimmune syndromes or certain environmental factors.

Aims: The aim of this study was to evaluate the serum level of iron, copper, and calcium and to assess their role in premature hair graying. Read More

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http://dx.doi.org/10.4103/ijt.ijt_8_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369637PMC
February 2019

Nuchal Nevus Flammeus and Alopecia Areata: When Size Matters.

Int J Trichology 2018 Nov-Dec;10(6):275-277

Department of Dermatology, Hospital Clínic de Barcelona, Barcelona, Spain.

Introduction: Alopecia areata (AA) is a high-prevalence immuno-mediated hair loss disorder. Extra follicular affections, including nail and ocular abnormalities, are classically related to a worse prognosis of the disease, and previous studies have suggested that the presence of a persistent nuchal nevus flammeus (NNF) also indicates a greater severity and duration of the disease. The association between AA and persistent NNF was first described by Hatzis et al in 1988, who demonstrated that the relation was statistically evident and not due to a simple observer bias. Read More

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http://dx.doi.org/10.4103/ijt.ijt_82_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369638PMC
February 2019

The Impact of Alopecia Areata on Sexual Quality of Life.

Int J Trichology 2018 Nov-Dec;10(6):271-274

Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Alopecia areata (AA) is an autoimmune disease characterized by patches of hair loss that can cause decreased quality of life. This study evaluates the sexual quality of life for patients with AA.

Methods: We surveyed patients in the National Alopecia Areata Foundation patient registry using an online version of the validated Sexual Quality of Life for Females (SQOL-F) and Sexual Quality of Life for Males (SQOL-M) questionnaires. Read More

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http://dx.doi.org/10.4103/ijt.ijt_93_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369646PMC
February 2019

Scalp Condition Impacts Hair Growth and Retention via Oxidative Stress.

Int J Trichology 2018 Nov-Dec;10(6):262-270

Sharon Woods Innovation Center, Cincinnati, OH, USA.

Conventionally, the medical focus has been either on hair loss or the condition of the scalp in terms of specific dermatological diseases. Indeed, the proximate structural arrangement of the scalp and hair leads to an interdependent relationship between the two. While protective benefits of the hair to the scalp are obvious, the role of the scalp as an incubatory environment for the preemergent hair fiber has largely been ignored. Read More

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http://dx.doi.org/10.4103/ijt.ijt_57_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369642PMC
February 2019

A Comment on the Post-Finasteride Syndrome.

Int J Trichology 2018 Nov-Dec;10(6):255-261

Center for Dermatology and Hair Diseases Professor Trüeb, Zurich-Wallisellen, Switzerland.

The post-Finasteride syndrome (PFS) has been claimed to occur in men who have taken oral finasteride to treat hair loss or benign prostatic hyperplasia. While the incidence of persistent sexual, mental, and physical side effects despite quitting finasteride is unknown, and the condition is not recognized by the scientific community, individuals who suffer from PFS do present with very distinctive and homogenous symptoms. The concept has emerged from reports of nondermatologists, neuroendocrinological research, case reports, and uncontrolled studies. Read More

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http://dx.doi.org/10.4103/ijt.ijt_61_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369643PMC
February 2019

A Comment on the Science of Hair Aging.

Int J Trichology 2018 Nov-Dec;10(6):245-254

Department of Dermatology, Universidade Federal Fluminense, Centro de Ciencias Medicas, Hospital Universitario Antonia Pedro, Niterói-Rio de Janeiro, Brazil.

In contrast to the skin, aging of the hair has seemingly only recently found the attention of dermatological meetings, mainly promoted by the cosmetic industry for marketing purposes. In fact, basic scientists interested in the biology of hair growth and pigmentation have for some time already exposed the hair follicle as a highly accessible model with unique opportunities for the study of age-related effects. As a result, the science of hair aging focuses on two main streams of interest: the esthetic problem of aging hair and its management, in terms of age-related effects on hair color, quantity, and quality; and the biological problem of aging hair, in terms of microscopic, biochemical, and molecular changes underlying the aging process. Read More

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http://dx.doi.org/10.4103/ijt.ijt_56_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369639PMC
February 2019

A case of capecitabine-induced dermatomyositis.

Indian J Pharmacol 2018 Nov-Dec;50(6):350-353

Department of Dermatology, MLN Medical College, Allahabad, Uttar Pradesh, India.

Dermatomyositis (DM) is an idiopathic, inflammatory connective tissue disorder characterized by symmetrical proximal myopathy and characteristic skin involvement. The pathogenesis of DM is widely debated; however, it is postulated to be an end result of immune-mediated cascade, triggered by multiple environmental factors in a genetically predisposed individual. In addition to underlying malignancies, many drugs have been reported to be associated with DM. Read More

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http://dx.doi.org/10.4103/ijp.IJP_356_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364339PMC
February 2019

Magnitude of Mental Morbidity and Its Correlates with Special Reference to Household Food Insecurity among Adult Slum Dwellers of Bankura, India: A Cross-Sectional Survey.

Indian J Psychol Med 2019 Jan-Feb;41(1):54-60

Department of Community Medicine, Principal, Bankura Sammilani Medical College, Bankura, West Bengal, India.

Background: Mental disorders cause considerable morbidity and disability, and there is ample evidence that mental disorders are positively associated with household food insecurity.

Methods: A cross-sectional survey was conducted for a period of 2 months at Bakultala slum of Bankura town involving 152 people of ≥18 and ≤60 years of age selected using simple random sampling technique to estimate the prevalence of mental disorders and to find out its correlates. Information pertaining to socio-demographics and household food security (HHFS) and " potential psychiatric case" were collected through a house to house interview of the head of the household, using predesigned questionnaire, Bengali version of self-reporting questionnaire, and 6-item household food security scale (HFSS). Read More

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http://dx.doi.org/10.4103/IJPSYM.IJPSYM_129_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337931PMC
February 2019

Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin.

Skin Pharmacol Physiol 2019 Feb 15;32(2):94-100. Epub 2019 Feb 15.

Department of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Halle (Saale),

Background/aims: Free amino acids (FAAs) and urea, present inside the corneocytes, can be important indicators of skin condition. However, due to the lack of a standard extraction protocol for FAAs from corneocytes, conflicting research results have been reported. Therefore, the purpose of this study was (1) to standardize the extraction protocol and (2) to investigate FAA profiles in healthy young and healthy old volunteers, as well as in psoriasis and atopic dermatitis patients. Read More

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http://dx.doi.org/10.1159/000495992DOI Listing
February 2019