201,944 results match your criteria Dermatology Basel Switzerland[Journal]


Drugs of porcine origin - a risk for patients with α-Gal syndrome?

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg. Electronic address:

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December 2018

Comparison of International Systemic Adverse Reactions due to Allergen Immunotherapy.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Section of Allergy and Clinical Immunology, Imperial College London, National Heart and Lung Institute, Royal Brompton Hospital, London, UK.

Background: Several classifications of systemic adverse reactions (SAR) during allergen immunotherapy (AIT) have been proposed but the comparison of their usefulness in daily clinical practice is lacking.

Objective: The present post hoc analysis was aimed to investigate the practicality of the most relevant international classifications proposed by the European Academy of Allergology and Clinical Immunology (EAACI), the American Academy of Asthma, Allergology and Clinical Immunology /American College of Allergy, Asthma and Immunology (AAAACI/ACAAI), and the World Allergy Organization (WAO) using data provided by the longitudinal European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI) based on daily clinical practice in 3 countries in Europe.

Methods: One hundred and nine SAR over 4363 AIT courses were classified as mild (n=78, 71. Read More

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December 2018
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Mast Cell Granules: Modulating adaptive immune response remotely.

J Allergy Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Immune Imaging Program Centenary Institute, Faculty of Medicine and Health The University of Sydney, Camperdown, NSW 2050, Australia; Discipline of Dermatology, Faculty of Medicine and Health University of Sydney, NSW 2006, Australia; Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria.

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December 2018
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In response to: "New validated diagnostic criteria for pyoderma gangrenosum".

J Am Acad Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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December 2018

New validated diagnostic criteria for pyoderma gangrenosum.

J Am Acad Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Immunology and Rheumatology, Department of Dermatology, Stanford University, Stanford, California; Division of Immunology and Rheumatology, Department of Internal Medicine, Stanford University, Stanford, California.

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December 2018

HIV screening among patients seeking care at Xuanwu Hospital: A cross-sectional study in Beijing, China, 2011-2016.

PLoS One 2018 17;13(12):e0208008. Epub 2018 Dec 17.

National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Objectives: One-third of people living with HIV in China are still unaware of their status, so we sought to better understand HIV testing in the general hospital setting in China.

Methods: A cross-sectional study was conducted using the electronic medical records of all patients who attended Xuanwu Hospital in Beijing, January 1, 2011 to December 31, 2016. HIV screening and detection rates and characteristics of patients diagnosed with HIV were assessed. Read More

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December 2018

Correlation of serum tryptase levels with total number of nevi, Breslow thickness, ulceration, and mitotic index in melanoma patients: evaluation of a promising prognostic marker.

Melanoma Res 2018 Dec 15. Epub 2018 Dec 15.

Dermatologic Clinic, Departement of Internal Medicine and Medical Specialties, La Sapienza University of Rome.

Current evidences suggest that mast cells contribute to the proliferation and differentiation of skin melanocytes. According to these findings, we carried out an observational cross-sectional study to investigate the correlation between the total number of nevi (TN), Breslow thickness (BT), and serum tryptase (ST) levels in a cohort of 35 melanoma (MM) patients. A Mann-Whitney test was performed to compare ST values within each variable. Read More

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December 2018
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Prognosis of dysphagia in dermatomyositis.

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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November 2018

Ixekizumab improves patient-reported outcomes in patients with active psoriatic arthritis and inadequate response to tumour necrosis factor inhibitors: SPIRIT-P2 results to 52 weeks.

Clin Exp Rheumatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Medicine, Rheumatology Research Unit, University of Queensland, Sunshine Coast, QLD, Australia.

Objectives: To report patient-reported outcomes (PROs) of ixekizumab-treated patients with psoriatic arthritis (PsA) and an inadequate response (IR) or intolerance to tumour necrosis factor inhibitors (TNFi) to 52 weeks.

Methods: In SPIRIT-P2, patients with active PsA and an IR or intolerance to TNFi were randomised to ixekizumab 80 mg every 4 weeks (IXEQ4W; N=122) or every 2 weeks (IXEQ2W; N=123), or placebo (PBO; N=118) during the initial 24-week double-blind treatment period. At Week 16, background therapy was modified for IRs; additionally, IRs in the placebo group were re-randomised (1:1) to IXEQ2W or IXEQ4W. Read More

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November 2018
2 Reads

Letters.

J Wound Care 2018 Dec;27(12):892-893

Plasma Physicist, HAWK - University of Applied Sciences and Arts, Göttingen, and Application Center for Plasma and Photonics, Fraunhofer Institute for Surface Engineering and Thin Films IST, Göttingen, Germany.

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December 2018

Health Care Utilization and Cost Associated with Biologic Treatment Patterns Among Patients with Moderate to Severe Psoriasis: Analyses from a Large U.S. Claims Database.

J Manag Care Spec Pharm 2018 Dec 17:1-11. Epub 2018 Dec 17.

3 Health Economics & Outcomes Research, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.

Background: Discontinuation or switching of biologic treatment among patients with psoriasis imposes a great economic burden.

Objective: To assess the health care utilization and costs associated with nonswitchers, switchers, and discontinuers of biologics among patients with moderate to severe psoriasis.

Methods: Patients aged ≥ 18 years with ≥ 1 pharmacy claim for a biologic (adalimumab, etanercept, infliximab, and ustekinumab) between January 1, 2012, and June 30, 2015 (identification period), were identified in the Truven Health Analytics MarketScan Commercial and Medicare Supplemental databases. Read More

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December 2018

ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.

Mol Oncol 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Medicine, University of Freiburg, Germany.

A disintegrin and a metalloprotease (ADAM) 9 is a metzincin cell-surface protease with strongly elevated expression in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9 in a cohort of > 100 clinically-annotated PDAC cases. We report that ADAM9 is prominently expressed by PDAC tumor cells, and increased ADAM9 expression levels correlate with poor tumor grading (p = 0. Read More

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December 2018

RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.

Int J Cancer 2018 Dec 17. Epub 2018 Dec 17.

The Centenary Institute, The University of Sydney, Newtown, NSW, Australia.

Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A was overexpressed in a subset of melanomas, which correlated with poor patient survival. Read More

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December 2018

The impact of pediatric atopic dermatitis on families: A review.

Pediatr Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Department of Dermatology, University of California San Francisco, San Francisco, California.

Background: Atopic dermatitis (AD) is an extremely common childhood disease, with considerable impact on the quality of life of affected children and their families. While pruritus is the hallmark symptom of this disease, AD has been well-documented to impact patients beyond physical symptoms, resulting in behavior problems, mood disorders, and sleep disturbance.

Objective: This literature review outlines how atopic dermatitis impacts the quality of life of families of children affected by AD. Read More

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December 2018

BRAF kinase inhibitors for treatment of melanoma: developments from early-stage animal studies to Phase II clinical trials.

Expert Opin Investig Drugs 2018 Dec 16:1-6. Epub 2018 Dec 16.

a Department of Dermatology , Tohoku University Graduate School of Medicine , Aoba-ku, Sendai , Japan.

Introduction: Approximately, 30.4-66.0% of cutaneous melanomas possess a mutation in the BRAF gene that activates downstream signaling through the mitogen-activated protein (MAP) kinase pathway; this provides an attractive target for the treatment of advanced melanoma. Read More

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December 2018

Margin-Controlled, Staged Surgical Excision in the Treatment of High-Risk Basal Cell Carcinomas of the Head and Neck Region.

J Cutan Med Surg 2018 Dec 17:1203475418820868. Epub 2018 Dec 17.

2 Department of Plastic Reconstructive and Aesthetic Surgery, Marmara University School of Medicine, Istanbul, Turkey.

Background:: The most common skin cancer is basal cell carcinoma (BCC), and the gold-standard treatment for high-risk tumours is Mohs surgery. However, alternative methods are needed for high-risk tumours in countries where the performance rate of Mohs surgery is low.

Objectives:: The objective of this article is to investigate the feasibility, efficacy, and safety of margin-controlled, staged surgical excision (MCSSE) in high-risk tumours as a possible treatment alternative. Read More

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December 2018
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Distinction of Condylomata Acuminata from Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2018 Dec 17:1203475418819992. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background:: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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December 2018
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Psoriasis and Atopic Dermatitis "Resistant" to Topical Treatment Responds Rapidly to Topical Desoximetasone Spray.

J Cutan Med Surg 2018 Dec 17:1203475418818082. Epub 2018 Dec 17.

1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose:: Topical corticosteroids (TS) are a treatment for atopic dermatitis (AD) and psoriasis (Ps). We assessed whether use of a TS under conditions designed to enhance adherence would be effective in patients who "failed" TS in the outpatient setting.

Methods:: Individuals with treatment-resistant Ps or AD were recruited (AD, n = 12; Ps, n = 12). Read More

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December 2018

Cellular retinol-binding protein-1 expression increases with increasing clinical severity of alopecia areata.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Department of Pathology, Faculty of medicine, Tanta University, Tanta, Egypt.

Background: Alopecia areata (AA) is multifactorial disease mostly autoimmune affecting anagen hair follicles. Many researchers hypothesize that adequate retinoic acid (RA) levels are important for proper hair follicle behavior. Previous animal studies revealed increase in RA synthesis proteins and decrease in RA degradation proteins in AA patients when compared with controls. Read More

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December 2018
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A case of ochronosis successfully treated with the picosecond laser.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Clínica Dermatológica Isela Méndez, Ciudad de México, México.

Exogenous ochronosis is a cutaneous condition characterized by blue-black pigmentation resulting as a complication of long-term application of skin-lightening creams containing hydroquinone and other substances such as quinine, phenol and mercury derivatives. We report a case of a 55-year-old woman who developed exogenous ochronosis as a result of prolonged use of topical hydroquinone for 5 years, characterized by greyish hyperpigmented patches on the nose and cheeks. The diagnosis was confirmed histologically. Read More

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December 2018
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Dermoscopic pre- and posttreatment evaluation in patients with androgenetic alopecia on platelet-rich plasma-A prospective study.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Dermatology, Venereology and Leprosy, A. J. Institute of Medical Sciences, Mangalore, India.

Background: Platelet-rich plasma is rich in growth factors that promote differentiation and growth of dermal papilla cells by various signaling pathways. Dermoscopy is handy, bedside tool that helps to improve diagnostic accuracy in various hair disorders.

Objectives: To evaluate and study the role of dermoscopy in patients with androgenetic alopecia (AGA) pre- and posttreatment with platelet-rich plasma (PRP). Read More

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December 2018

A recurrent mutation in KCNQ4 in Korean families with nonsyndromic hearing loss and rescue of the channel activity by KCNQ activators.

Hum Mutat 2018 Dec 17. Epub 2018 Dec 17.

Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, Korea.

Mutations in potassium voltage-gated channel subfamily Q member 4 (KCNQ4) are etiologically linked to nonsyndromic hearing loss (NSHL), deafness nonsyndromic autosomal dominant 2 (DFNA2). To identify causative mutations of hearing loss in 98 Korean families, we performed whole exome sequencing. In three independent families with NSHL, we identified a cosegregating heterozygous missense mutation, c. Read More

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December 2018

Relationship between diet, atopy, family history, and premature hair graying.

J Cosmet Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Faculty of Medicine, Department of Statistics, Eskişehir Osmangazi University, Eskisehir, Turkey.

Aim: Premature hair graying (PHG) is commonly observed in society, but there are a few studies evaluating risk factors associated with PHG. We aimed to evaluate the socio-clinical risk factors associated with PHG in this study.

Methods: A total of 1192 volunteers between 18 and 20 years old were included in this cross-sectional study. Read More

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December 2018

Review of future insights of Dragon's Blood in dermatology.

Dermatol Ther 2018 Nov 22:e12786. Epub 2018 Nov 22.

Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, North Carolina.

To assess the possible clinical implication of Dragon's Blood in dermatology, a PubMed search was conducted using the keyword "Dragon's Blood," "Croton lechleri," and more. Dragon's Blood from C. lechleri is an Amazonian medicinal plant with a characteristic red sap. Read More

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November 2018

"Slime" dermatitis, a fad-associated chronic hand dermatitis.

Pediatr Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Division of Dermatology, Children's National Health Center, Washington, District of Columbia.

"Slime" is the colloquial name for a non-Newtonian viscoelastic putty-like substance that is currently a popular plaything among pre-teens and adolescents. Several ingredients in homemade slime recipes may cause irritant or allergic contact dermatitis. We report two children who developed slime-associated chronic hand dermatitis, more prominently on their dominant hand. Read More

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December 2018

The use of dermoscopy in differentiating Sister Mary Joseph nodule and cutaneous endometriosis.

Australas J Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.

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December 2018

Completion Lymph Node Dissection or Radiation Therapy for Sentinel Node Metastasis in Merkel Cell Carcinoma.

Ann Surg Oncol 2018 Dec 17. Epub 2018 Dec 17.

Division of Surgical Oncology, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109-5932, USA.

Background: For sentinel lymph node (SLN) metastasis from Merkel cell carcinoma (MCC), the benefit of completion lymph node dissection (CLND) versus radiation therapy (RT) is unclear. This study compares outcomes for patients with SLN metastasis undergoing CLND or RT. We also evaluated positive non-SLNs as a prognostic factor. Read More

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December 2018

Pancreatic Enzyme Supplementation in Patients with Atopic Dermatitis and Food Allergies: An Open-Label Pilot Study.

Paediatr Drugs 2018 Dec 17. Epub 2018 Dec 17.

Division of Gastroenterology, Departments of Medicine and Pediatrics, Research Institute of the McGIll University Health Centre, 1650 Cedar Avenue C10.145, Montreal, QC, H3G 1A4, Canada.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects both patients and their families. Current therapies often alleviate symptoms but do not prevent or eradicate the disease.

Objectives: Our objective was to determine whether pancreatic enzyme supplementation is an effective and safe treatment in refractory pediatric AD associated with food allergies. Read More

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December 2018
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The prevalence and characteristics of local allergic rhinitis in Poland.

Rhinology 2018 Dec 17. Epub 2018 Dec 17.

Clinical Department of Otorhinolaryngology and Laryngological Oncology in Zabrze, Medical University of Silesia, Katowice, Poland.

Background: Local allergic rhinitis (LAR) is found in some patients with typical symptoms but who have negative skin prick tests and negative IgE to aeroallergens while presenting with positive nasal provocation tests for proper allergens. Little information about the clinical characteristics and prevalence of LAR has been published. The aim of this study was to determine the prevalence and characteristics of LAR in patients with symptoms of chronic rhinitis. Read More

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December 2018
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Concordance and Reproducibility of Melanoma Staging According to the 7th vs 8th Edition of the .

JAMA Netw Open 2018 May;1(1)

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (Elmore); Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia (Elder); Department of Pathology, Institut Curie, Paris, France (Barnhill); Paris Sciences and Lettres Research University, Paris, France (Barnhill); Faculty of Medicine, University of Paris Descartes, Paris, France (Barnhill); Pathology Associates, Clovis, California (Knezevich); Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, Washington (Longton, Pepe); Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire (Titus); Department of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire (Titus); Norris Cotton Cancer Center, Lebanon, New Hampshire (Titus); Center for Dermatoepidemiology, Providence Veterans Affair Medical Center, Providence, Rhode Island (Weinstock); Department of Dermatology, Brown University, Providence, Rhode Island (Weinstock); Department of Epidemiology, Brown University, Providence, Rhode Island (Weinstock); Department of Medical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health and Science University, Portland (Nelson); Department of Medicine, School of Medicine, Oregon Health and Science University, Portland (Nelson); Department of Medicine, University of Washington School of Medicine, Seattle (Reisch, Radick, Piepkorn); Dermatopathology Northwest, Bellevue, Washington (Piepkorn).

Importance: The recently updated American Joint Committee on Cancer (AJCC) classification of cancer staging, the , 8th edition (), includes revisions to definitions of T1a vs T1b or greater. The Melanoma Pathology Study database affords a comparison,of pathologists' concordance and reproducibility in the microstaging of melanoma according to both the existing 7th edition ) and the new .

Objective: To compare and to examine whether changes to the definitions of T1a and T1b or greater are associated with changes in concordance and reproducibility. Read More

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May 2018
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Toxic cutaneous responses from inhalant abuse.

JAAD Case Rep 2019 Jan 4;5(1):31-33. Epub 2018 Dec 4.

Department of Dermatology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio.

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January 2019

Cold burn injury after treatment at whole-body cryotherapy facility.

JAAD Case Rep 2019 Jan 4;5(1):29-30. Epub 2018 Dec 4.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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January 2019

Patient selection criteria and innovative techniques for improving outcome and cosmesis in acne keloidalis nuchae lesion excision and primary closure.

JAAD Case Rep 2019 Jan 4;5(1):24-28. Epub 2018 Dec 4.

Dermatology Division, Harbor-UCLA Department of Medicine, Torrance, California.

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January 2019
1 Read

Eruptive melanocytic nevi in a patient with Parkinson disease treated by carbidopa-levodopa.

JAAD Case Rep 2019 Jan 4;5(1):21-23. Epub 2018 Dec 4.

Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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January 2019

Antioxidant properties of topical extract on UVB-induced photoaging in mice.

Dermatol Reports 2018 Oct 1;10(2):7597. Epub 2018 Oct 1.

Virology Laboratory, Faculty of Veterinary Medicine, Udayana University, Indonesia.

, a genus of seaweed native to the Indo-Pacific region, has been known for its antioxidant properties and health benefits when consumed as food. Previous studies have reported 's potential as a strong antioxidant, but its effects on the skin in a topical preparation, especially its role in ultraviolet (UV) protection, have not been studied extensively. Our study investigated the protective effects of 0. Read More

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October 2018

Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target.

Authors:
Claudia Buerger

Front Immunol 2018 30;9:2786. Epub 2018 Nov 30.

Department of Dermatology, Venerology and Allergology, Clinic of the Goethe University, Frankfurt am Main, Germany.

Although modern biologics targeting different inflammatory mediators show promising therapeutic success, comprehensive knowledge about the molecular events in psoriatic keratinocytes that contribute to the pathogenesis and could serve as therapeutic targets is still scarce. However, recent efforts to understand the deregulated signal transduction pathways have led to the development of small molecule inhibitors e.g. Read More

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November 2018

Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon.

Front Immunol 2018 28;9:2746. Epub 2018 Nov 28.

Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland.

Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/T17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory diseases such as psoriasis. Read More

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November 2018

Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool.

Stem Cell Reports 2018 Dec 6. Epub 2018 Dec 6.

Pennsylvania Cancer and Regenerative Medicine Research Center, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902, USA; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 637551, Singapore. Electronic address:

DACH1 abundance is reduced in human malignancies, including breast cancer. Herein DACH1 was detected among multipotent fetal mammary stem cells in the embryo, among mixed lineage precursors, and in adult basal cells and (ERα) luminal progenitors. Dach1 gene deletion at 6 weeks in transgenic mice reduced ductal branching, reduced the proportion of mammary basal cells (Lin CD24 CD29) and reduced abundance of basal cytokeratin 5, whereas DACH1 overexpression induced ductal branching, increased Gata3 and Notch1, and expanded mammosphere formation in LA-7 breast cells. Read More

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December 2018

Visualizing the Contribution of Keratin-14 Limbal Epithelial Precursors in Corneal Wound Healing.

Stem Cell Reports 2018 Dec 3. Epub 2018 Dec 3.

Mechanisms of Disease and Translational Research, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

It is thought that corneal epithelial injuries resolve by leading-edge cells "sliding" or "rolling" into the wound bed. Here, we challenge this notion and show by real-time imaging that corneal wounds initially heal by "basal cell migration." The K14CreER-Confetti multi-colored reporter mouse was employed to spatially and temporally fate-map cellular behavior during corneal wound healing. Read More

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December 2018

High prevalence of clinical spondyloarthritis features in patients with hidradenitis suppurativa.

J Am Acad Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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December 2018

The national burden of inpatient dermatology in adults.

J Am Acad Dermatol 2018 Dec 13. Epub 2018 Dec 13.

George Washington University School of Medicine and Health Sciences, Washington, DC; Division of Dermatology, Children's National Health System, Washington, DC. Electronic address:

Background: Management of inpatient skin disease represents a unique subspecialty within dermatology.

Objective: To assess the national burden of inpatient dermatology in adults.

Methods: Using the 2014 National Inpatient Sample, we performed a retrospective cohort study of adults hospitalized for dermatologic conditions. Read More

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December 2018

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.

Authors:
Nasim Mavaddat Kyriaki Michailidou Joe Dennis Michael Lush Laura Fachal Andrew Lee Jonathan P Tyrer Ting-Huei Chen Qin Wang Manjeet K Bolla Xin Yang Muriel A Adank Thomas Ahearn Kristiina Aittomäki Jamie Allen Irene L Andrulis Hoda Anton-Culver Natalia N Antonenkova Volker Arndt Kristan J Aronson Paul L Auer Päivi Auvinen Myrto Barrdahl Laura E Beane Freeman Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Leslie Bernstein Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Bernardo Bonanni Anne-Lise Børresen-Dale Hiltrud Brauch Michael Bremer Hermann Brenner Adam Brentnall Ian W Brock Angela Brooks-Wilson Sara Y Brucker Thomas Brüning Barbara Burwinkel Daniele Campa Brian D Carter Jose E Castelao Stephen J Chanock Rowan Chlebowski Hans Christiansen Christine L Clarke J Margriet Collée Emilie Cordina-Duverger Sten Cornelissen Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Thilo Dörk Isabel Dos-Santos-Silva Martine Dumont Lorraine Durcan Miriam Dwek Diana M Eccles Arif B Ekici A Heather Eliassen Carolina Ellberg Christoph Engel Mikael Eriksson D Gareth Evans Peter A Fasching Jonine Figueroa Olivia Fletcher Henrik Flyger Asta Försti Lin Fritschi Marike Gabrielson Manuela Gago-Dominguez Susan M Gapstur José A García-Sáenz Mia M Gaudet Vassilios Georgoulias Graham G Giles Irina R Gilyazova Gord Glendon Mark S Goldberg David E Goldgar Anna González-Neira Grethe I Grenaker Alnæs Mervi Grip Jacek Gronwald Anne Grundy Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A Haiman Niclas Håkansson Ute Hamann Susan E Hankinson Elaine F Harkness Steven N Hart Wei He Alexander Hein Jane Heyworth Peter Hillemanns Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Guanmengqian Huang Keith Humphreys David J Hunter Milena Jakimovska Anna Jakubowska Wolfgang Janni Esther M John Nichola Johnson Michael E Jones Arja Jukkola-Vuorinen Audrey Jung Rudolf Kaaks Katarzyna Kaczmarek Vesa Kataja Renske Keeman Michael J Kerin Elza Khusnutdinova Johanna I Kiiski Julia A Knight Yon-Dschun Ko Veli-Matti Kosma Stella Koutros Vessela N Kristensen Ute Krüger Tabea Kühl Diether Lambrechts Loic Le Marchand Eunjung Lee Flavio Lejbkowicz Jenna Lilyquist Annika Lindblom Sara Lindström Jolanta Lissowska Wing-Yee Lo Sibylle Loibl Jirong Long Jan Lubiński Michael P Lux Robert J MacInnis Tom Maishman Enes Makalic Ivana Maleva Kostovska Arto Mannermaa Siranoush Manoukian Sara Margolin John W M Martens Maria Elena Martinez Dimitrios Mavroudis Catriona McLean Alfons Meindl Usha Menon Pooja Middha Nicola Miller Fernando Moreno Anna Marie Mulligan Claire Mulot Victor M Muñoz-Garzon Susan L Neuhausen Heli Nevanlinna Patrick Neven William G Newman Sune F Nielsen Børge G Nordestgaard Aaron Norman Kenneth Offit Janet E Olson Håkan Olsson Nick Orr V Shane Pankratz Tjoung-Won Park-Simon Jose I A Perez Clara Pérez-Barrios Paolo Peterlongo Julian Peto Mila Pinchev Dijana Plaseska-Karanfilska Eric C Polley Ross Prentice Nadege Presneau Darya Prokofyeva Kristen Purrington Katri Pylkäs Brigitte Rack Paolo Radice Rohini Rau-Murthy Gad Rennert Hedy S Rennert Valerie Rhenius Mark Robson Atocha Romero Kathryn J Ruddy Matthias Ruebner Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Daniel F Schmidt Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Fredrick Schumacher Peter Schürmann Lukas Schwentner Christopher Scott Rodney J Scott Caroline Seynaeve Mitul Shah Mark E Sherman Martha J Shrubsole Xiao-Ou Shu Susan Slager Ann Smeets Christof Sohn Penny Soucy Melissa C Southey John J Spinelli Christa Stegmaier Jennifer Stone Anthony J Swerdlow Rulla M Tamimi William J Tapper Jack A Taylor Mary Beth Terry Kathrin Thöne Rob A E M Tollenaar Ian Tomlinson Thérèse Truong Maria Tzardi Hans-Ulrich Ulmer Michael Untch Celine M Vachon Elke M van Veen Joseph Vijai Clarice R Weinberg Camilla Wendt Alice S Whittemore Hans Wildiers Walter Willett Robert Winqvist Alicja Wolk Xiaohong R Yang Drakoulis Yannoukakos Yan Zhang Wei Zheng Argyrios Ziogas Alison M Dunning Deborah J Thompson Georgia Chenevix-Trench Jenny Chang-Claude Marjanka K Schmidt Per Hall Roger L Milne Paul D P Pharoah Antonis C Antoniou Nilanjan Chatterjee Peter Kraft Montserrat García-Closas Jacques Simard Douglas F Easton

Am J Hum Genet 2018 Dec 5. Epub 2018 Dec 5.

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Read More

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December 2018
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Thirteenth World Congress of the International Academy of Cosmetic Dermatology (IACD), Dubrovnik, Croatia, June 28 to July 1, 2018.

Clin Dermatol 2019 Jan - Feb;37(1):80-84. Epub 2018 Nov 19.

Department of Dermatology, MedStar Washington Hospital Center, Georgetown University School of Medicine, Washington, DC, USA. Electronic address:

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November 2018

Business administration training for dermatology residents: preparing for the business of medicine.

Clin Dermatol 2019 Jan - Feb;37(1):78-79. Epub 2018 Sep 19.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Previous studies have evidenced the lack of practice management and business training components in the residency curriculum, and that satisfaction with this training, when provided, was low. Whether considered good or bad, medicine has been moving increasingly toward becoming more business centric. Dermatology represents a unique field, because most residents choose to pursue private practice, where competent business skills are helpful to running a successful clinic. Read More

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September 2018

"But doctor, I googled it!": The "three Rs" of managing patients in the age of information overload.

Clin Dermatol 2019 Jan - Feb;37(1):74-77. Epub 2018 Aug 10.

Department of Neurology, Stanford University Hospitals and Clinics, Palo Alto, California, USA.

Managing patient interactions in the age of the Internet can be particularly difficult due to the vast amount of information available. Dermatologists should be able to identify relevant patient concerns to adequately address them. We discuss the ethical issues involved in interacting with patients who use the Internet for medical knowledge, and we suggest a method, using the "three Rs" (reassure, redirect, refer), to conduct these interactions. Read More

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The importance of the history of dermatology: An American viewpoint.

Clin Dermatol 2019 Jan - Feb;37(1):60-70. Epub 2018 Sep 17.

Department of Dermatology and Cutaneous Biology and the Jefferson Center for International Dermatology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

The history of dermatology is a significant aspect of the specialty, if only to put into perspective the development of the specialty. Early pioneers recorded the progress made in the specialty, as it became a separate discipline in the latter part of the 19th century. Periodically, dermatologic societies and meetings have shown interest by including sessions and exhibits on the specialty. Read More

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September 2018

Organize to serve: An ecclesiastical approach to medicine and dermatology.

Clin Dermatol 2019 Jan - Feb;37(1):56-59. Epub 2018 Sep 15.

Full Member-Elect (Individuo de Número) of the National Academy of Medicine in Venezuela, Emeritus Professor and Chairman of Dermatology and Immunology, Vargas School of Medicine, and Instituto Nacional de Dermatología, Central University of Venezuela, Caracas. Electronic address:

Maintenance and promotion of health are worldwide activities, yet those devoted by their profession to these goals are currently hopelessly fractionated and involved in struggling for territory and self-sustenance. The author proposes the creation of a World Medical Congregation, eventually encompassing all physicians. This integrative endeavor would model itself after the governance of the Roman Catholic Church, without the latter's obvious confessional characteristics. Read More

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September 2018

Open access medical journals: Benefits and challenges.

Clin Dermatol 2019 Jan - Feb;37(1):52-55. Epub 2018 Sep 15.

Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, USA. Electronic address:

The world of medical science literature is ever increasingly accessible via the Internet. Open access online medical journals, in particular, offer access to a wide variety of useful information at no cost. In addition, they provide avenues for publishing that are available to health care providers of all levels of training and practice. Read More

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September 2018

Returning: Thoughts about the editorial and publication processes in dermatology and medicine.

Clin Dermatol 2019 Jan - Feb;37(1):47-51. Epub 2018 Sep 15.

Full Member-Elect (Individuo de Número) of the National Academy of Medicine in Venezuela, and Emeritus Professor and Chairman of Dermatology and Immunology, Vargas School of Medicine and Instituto Nacional de Dermatología, Central University of Venezuela, Caracas, Venezuela. Electronic address:

It is the intention of the author to present his ideas about the ways in which scientific information in dermatology and medicine should be transmitted in writing. There is a brief analysis of practices in the past and of current procedures, along with ideas about what the near future will bring. The approach is conservative, according to the value given to traditional methods and to ethical considerations. Read More

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September 2018