1,565 results match your criteria Dermatologic Therapy[Journal]


Vitiligo in a patient receiving infliximab for chronic plaque psoriasis.

Dermatol Ther 2019 Apr 17:e12917. Epub 2019 Apr 17.

Department of Dermatology, Shanghai Skin Disease Hospital, 1278 Baode Road, Shanghai 200443, China.

Infliximab is a TNF-a Inhibitor widely used in the treatment of moderate to severe chronic plaque psoriasis. Here, we report a case of vitiligo following infliximab administration in a patient with chronic plaque psoriasis. The case serves as a reminder of vitiligo induced by TNF-a-antagonist therapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12917
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http://dx.doi.org/10.1111/dth.12917DOI Listing
April 2019
2 Reads

Validation of the Mid-Face Volume Deficit Scale using a new photo-guideline in the Asian population.

Dermatol Ther 2019 Apr 16:e12938. Epub 2019 Apr 16.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

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April 2019
1 Read

Woad extract containing cream improves significantly dry, irritated, and pruritic skin.

Dermatol Ther 2019 Apr 16:e12939. Epub 2019 Apr 16.

Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, 48149 Münster, Germany.

Objective of this open, non-interventional, non-controlled study was to investigate the tolerability and performance of a woad extract containing cream in subjects with dry, pruritic skin after twice daily application over two weeks. Assessments included sensorial characteristics, skin condition, pruritus [numeric rating scale (NRS), dynamic pruritus score (DPS)], skin dryness [itch-controlled days (ItchCD), overall dry skin (ODS)], transepidermal water loss (TEWL), skin hydration and quality of life (5PLQ, DLQI). All sensorial characteristics were well perceived (>4), with tolerability (4. Read More

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http://dx.doi.org/10.1111/dth.12939DOI Listing
April 2019
2 Reads

The SILVER Study. Efficacy Of Topical Nitric-Zinc Complex Solution In The Treatment Of Resistant Warts: A Post-Marketing Evaluation.

Dermatol Ther 2019 Apr 16:e12940. Epub 2019 Apr 16.

Department of Dermatology, Venereology and Allergology, Academic Teaching Department of Medical University Innsbruck, Central Hospital Bolzano/Bozen, Bolzano, Italy.

Background: The treatment of cutaneous viral warts caused by human papillomavirus (HPV) infection is often subject to local recurrence and a long clinical and treatment course. Our aim was to analyze real-life data on the treatment of difficult-to-treat warts from a multicenter post-marketing surveillance assessment on the efficacy, tolerability and safety of a commercially available nitric-zinc complex solution (NZCS).

Methods: Dermatologists from 14 Italian centers completed a questionnaire about their clinical experience on treatment of "difficult-to-treat" warts, which included plantar, periungual, anogenital wartsand warts on aesthetically sensitive areas. Read More

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http://dx.doi.org/10.1111/dth.12940DOI Listing
April 2019
1 Read

Cosmetical treatments of connective tissue disorders.

Authors:
Deniz Aksu Arica

Dermatol Ther 2019 Apr 15:e12935. Epub 2019 Apr 15.

Department of Dermatology and Venereology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Connective tissue disorders (CTDs) are chronic inflammatory conditions that can lead to scarring and disfiguration. Although conventional methods are often of little benefit in cutaneous manifestations, the use of cosmetic procedures is still controversial. Concerns have also been raised concerning cosmetic treatments in CTDs, and particularly regarding lasers and fillers, due to photosensitivity and potential reactivation. Read More

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http://dx.doi.org/10.1111/dth.12935DOI Listing

Secukinumab versus ustekinumab for skin clearance in patients with moderate to severe psoriasis after a year of treatment: real-world practice.

Dermatol Ther 2019 Apr 15:e12937. Epub 2019 Apr 15.

Dermatology Unit, Hospital Virgen de la Victoria, Málaga, Spain.

A descriptive retrospective, study comparing the first 29 patients who received ustekinumab at our unit following its approval in September 2009 with 30 patients who received secukinumab after its marketing in Spain in November 2015 was conducted. The secukinumab treatment group showed higher whitening rates and a higher percentage of patients reached a psoriasis area and severity index (PASI) 75 response (89.65% vs 73. Read More

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http://dx.doi.org/10.1111/dth.12937DOI Listing

Efficacy of biologic therapies in Psoriasis Vulgaris.

Dermatol Ther 2019 Apr 15:e12936. Epub 2019 Apr 15.

Dermatology Department, University of Medicine, Tirana, Albania.

Background: Psoriasis is a chronic, immune-mediated skin disease that also has systemic manifestations. Biologic preparates : Adalimumab, Etanercept and Infliximab are licensed for Psoriasis Vulgaris treatment in Albania.

Purpose: To compare the efficacy of biologic therapies used for psoriasis based in our experience. Read More

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http://dx.doi.org/10.1111/dth.12936DOI Listing

52 Week Follow-Up Safety and Effectiveness Results of Dupilumab Treatment of Moderate to Severe Atopic Dermatitis From A Retrospective, Multicentric Series.

Dermatol Ther 2019 Apr 13:e12931. Epub 2019 Apr 13.

Dermatology Unit, Hospital Universitario Virgen del Rocio, Sevilla.

Atopic dermatitis (AD) is a chronic, systemic disease that has a multifactorial etiology, where immune system disorders and epidermal barrier dysfunction are added to the influence of genetic and environmental factors. Dupilumab has been approved by US and EU regulatory agencies in 2017 for the treatment of moderate to severe atopic dermatitis in adult patients who are candidates for systemic treatment. In this short report, we present a retrospective, multicentric study, in which five hospitals in Andalusia, Spain, have taken part. Read More

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http://dx.doi.org/10.1111/dth.12931DOI Listing

Successful treatment of obstinate facial plane warts with combined dermabrasion and photodynamic therapy.

Dermatol Ther 2019 Apr 13:e12930. Epub 2019 Apr 13.

Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, Jiangsu, China.

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http://dx.doi.org/10.1111/dth.12930DOI Listing

Pyoderma gangrenosum succesfully treated with golimumab: Case report and review of the literature.

Dermatol Ther 2019 Apr 12:e12928. Epub 2019 Apr 12.

MD, Dermatological Clinic Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, Italy.

Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis frequently related to chronic inflammatory bowel disease often associated with exacerbation of intestinal disease and/or loss of treatment efficacy. However, in patients with comorbidities, such as diabetes, the diagnosis may be a challenge. Here we report the case of DA, a 68-year-old man with a history of ulcerative recto-colitis (URC), type II diabetes and arterial hypertension, who had been treated with Infliximab and Adalimumab in the past. Read More

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http://dx.doi.org/10.1111/dth.12928DOI Listing

Case series of post-purpuric darkness on the periorbital area after aesthetic surgery.

Dermatol Ther 2019 Apr 12:e12922. Epub 2019 Apr 12.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

Periorbital hyperpigmentation (POH) is a common condition encountered in dermatology practice. POH is caused by various exogenous and endogenous factors including excessive pigmentation, post-inflammatory hyperpigmentation (PIH) secondary to eczema, periorbital edema, excessive vascularity, and aging. (Freitag & Cestari, 2007; Roh & Chung, 2009; Sarkar et al. Read More

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http://dx.doi.org/10.1111/dth.12922DOI Listing
April 2019
3 Reads

An urticarial drug eruption caused by tofacitinib for alopecia universalis.

Dermatol Ther 2019 Apr 12:e12933. Epub 2019 Apr 12.

Department of Dermatology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia 3050.

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http://dx.doi.org/10.1111/dth.12933DOI Listing
April 2019
1 Read

Ferroptosis suppressed the growth of melanoma that may be related to DNA damage.

Dermatol Ther 2019 Apr 12:e12921. Epub 2019 Apr 12.

Department of Dermatology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.

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http://dx.doi.org/10.1111/dth.12921DOI Listing

Apremilast is effective in controlling the progression of adult vitiligo: a case series.

Dermatol Ther 2019 Apr 12:e12923. Epub 2019 Apr 12.

CUTIS Institute of Dermatology, Srinagar, Kashmir, India.

There are limited treatment options available to control the progression of vitiligo and most of these treatment options carry the risk of both short term as well as long-term adverse effects. Apremilast has emerged as a promising treatment option in psoriasis and many other cutaneous disorders. We report herein the successful use of oral apremilast therapy in controlling the progression of adult onset vitiligo in 13 patients. Read More

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http://dx.doi.org/10.1111/dth.12923DOI Listing

A case of atezolizumab-induced photodistributed bullous pemphigoid.

Dermatol Ther 2019 Apr 12:e12924. Epub 2019 Apr 12.

Division of Dermatology, University of California, Los Angeles.

Immunotherapy has revolutionized cancer therapy in recent years but is associated with unique immunologically-mediated adverse effects. Immunotherapy-induced bullous pemphigoid is an uncommon but established reaction that portends significant management implication as in most instances systemic treatment is required. We report a case of immunotherapy-associated bullous pemphigoid in a marked photodistribution, highlighting the diverse clinical presentations of this eruption. Read More

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http://dx.doi.org/10.1111/dth.12924DOI Listing

Complete healing of basal cell carcinoma under bendamustine and brentuximab vedotin therapy in a patient with cutaneous lymphoma.

Dermatol Ther 2019 Apr 12:e12934. Epub 2019 Apr 12.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University.

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http://dx.doi.org/10.1111/dth.12934DOI Listing
April 2019
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Cephalosporin-induced linear IgA dermatosis in a child: case report and literature review.

Dermatol Ther 2019 Apr 12:e12927. Epub 2019 Apr 12.

Department of Dermatology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Linear IgA dermatosis (LAD) is a rare, subepidermal blistering disease with mucocutaneous involvement. It may be idiopathic or drug induced. We describe a 4-year-old girl who presented with a vesiculobullous eruption after she had been treated with cefixime for urinary tract infection. Read More

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April 2019
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Successful Treatment of Spindle Cell Hemangiomas in a Patient with Maffucci Syndrome and Review of literatures.

Dermatol Ther 2019 Apr 12:e12919. Epub 2019 Apr 12.

Department of Dermatology, Division of Pediatric Dermatology, Stanford University School of Medicine, Stanford, CA.

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http://dx.doi.org/10.1111/dth.12919DOI Listing

Transdermal patches in dermatology.

Dermatol Ther 2019 Apr 12:e12925. Epub 2019 Apr 12.

Department of Dermatology, School of medicine, Mersin University, Turkey.

Transdermal patches are effective treatment modalities which have variety of advantages. Active ingredient in these systems are absorbed from skin and reach to blood circulation via capillaries. Bypassing hepatic metabolism, providing constant plasma levels of drug for long time, fewer drug interactions are the main advantages of this method. Read More

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April 2019
2 Reads

Direct Acting Antiviral-induced/exacerbated psoriasis: Addendum!

Dermatol Ther 2019 Apr 12:e12929. Epub 2019 Apr 12.

Unit of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari, Italy.

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http://dx.doi.org/10.1111/dth.12929DOI Listing
April 2019
5 Reads

Biologics in Dermatology: What Does The Future Hold ?

Authors:
Cahit Yavuz

Dermatol Ther 2019 Apr 12:e12932. Epub 2019 Apr 12.

Konya Training and Research Hospital, Department of Dermatology, Konya, Turkey.

As the first dermatological biological treatment, infliximab was first used in the treatment of psoriasis in 2001. Since that time many biological agents have come into use for dermatological diseases and developments in this area are still ongoing. The most important feature of biological treatments is that the treatment must be target directed. Read More

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http://dx.doi.org/10.1111/dth.12932DOI Listing

Ineffectiveness of radiotherapy for the treatment of keratoacanthoma centrifugum marginatum: A case report.

Dermatol Ther 2019 Apr 12:e12920. Epub 2019 Apr 12.

Department of Dermatology, Hitachi General Hospital, Hitachi, Japan.

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http://dx.doi.org/10.1111/dth.12920DOI Listing

Pemphigus subtype: A confounder in determining the association of oral involvement with post-rituximab relapses.

Dermatol Ther 2019 Apr 12:e12918. Epub 2019 Apr 12.

Department of Dermatology, University of Illinois at Chicago.

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http://dx.doi.org/10.1111/dth.12918DOI Listing

Intralesional interleukin-2: a novel option to maximize response to systemic immune checkpoint therapy in loco-regional metastatic melanoma.

Dermatol Ther 2019 Apr 11:e12901. Epub 2019 Apr 11.

Department of Dermatology, University of Luebeck, Germany.

The management of metastatic melanoma has been transformed by the development of immune checkpoint inhibitors. However, disease control in patients with extensive locoregional metastases remains a significant challenge. In this context, intralesional interleukin 2 (IL-2) presents a useful therapeutic option to maximize intratumoural drug concentration and minimize systemic toxicity. Read More

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http://dx.doi.org/10.1111/dth.12901DOI Listing
April 2019
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Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Up-Regulating Follicular Sulfotransferase Enzymes.

Dermatol Ther 2019 Apr 11:e12915. Epub 2019 Apr 11.

Applied Biology, California, USA.

Minoxidil sulfate is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil. For hair growth, sulfotransferase enzymes expressed in outer root sheath of the hair follicle sulfonate minoxidil. The large intra-subject variability in follicular sulfotransferase was found to predict minoxidil response and thus explain the low response rate to topical minoxidil in the treatment of androgenetic alopecia. Read More

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http://dx.doi.org/10.1111/dth.12915DOI Listing
April 2019
1.478 Impact Factor

Biologics for psoriasis: What is new?

Dermatol Ther 2019 Apr 11:e12916. Epub 2019 Apr 11.

University of Health Science, Kayseri Health Training and Research Center, Dermatology and Venereology Clinic. Kayseri, Turkey.

Etiology of psoriasis is unclear but environmental, genetic, and immune factors act significant roles in the pathogenesis of this disease. Helper Tcells (TH), plasmoid and dermal dendritic cells play a prominent role in the development of classical psoriatic lesions. Interleukin stimulation is another important process in the pathogenesis of the disease that directly influences keratinocytes and leading to the formation of psoriatic pattern in the skin. Read More

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April 2019
6 Reads

Biologic therapy for acrodermatitis continua of Hallopeau: successful treatment with secukinumab and review of the literature.

Dermatol Ther 2019 Apr 10:e12899. Epub 2019 Apr 10.

Dermatology, Department of "Medicina dei Sistemi", University of Rome "Tor Vergata", Rome, Italy.

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http://dx.doi.org/10.1111/dth.12899DOI Listing
April 2019
1 Read

Low-irradiance red light compared to conventional red light in photodynamic therapy of actinic keratosis: a way to reduce pain during treatment.

Dermatol Ther 2019 Apr 9:e12913. Epub 2019 Apr 9.

INSERM, Univ. Lille, CHU Lille, U1189-OncoThAI - Image Assisted Laser Therapy for Oncology, Lille, France.

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http://dx.doi.org/10.1111/dth.12913DOI Listing

Basal cell carcinomas treated with 0.5% 5-fluorouracil and 10% salicylic acid topical solution.

Dermatol Ther 2019 Apr 9:e12908. Epub 2019 Apr 9.

Dermatologic Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.

Basal cell carcinomas are the most common non-melanoma skin cancers. Dermoscopy is an indispensable tool to differentiate superficial basal cell carcinoma from other subtypes and between pigmented and not pigmented ones. Although surgery is considered the gold-standard therapy, new current pharmacological options are available and focus on tumor eradication, increasing cosmetic results and functionality. Read More

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http://dx.doi.org/10.1111/dth.12908DOI Listing
April 2019
5 Reads

A Case of Recalcitrant Linear IgA Bullous Dermatosis: Successfully Treated with Rituximab.

Dermatol Ther 2019 Apr 9:e12911. Epub 2019 Apr 9.

Department of Dermatology, Faculty of Medicine, Selcuk University, Konya, Turkey.

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http://dx.doi.org/10.1111/dth.12911DOI Listing

Successful treatment of psoriatic crumbly nails with ustekinumab.

Dermatol Ther 2019 Apr 9:e12914. Epub 2019 Apr 9.

Dermatology Unit, University of Rome "Tor Vergata", Rome, Italy.

Nail involvement can place a significant burden on patients as a result of functional damage and psychosocial problems, leading to major repercussions on the quality of life. There is strong evidence that nail psoriasis can often be difficult to treat. We report a a 69 year-old-man with severe onychodystrophy, onycholysis, and pain in the hands; he had been previously treated with topical and systemic traditional therapies without satisfactory response. Read More

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http://dx.doi.org/10.1111/dth.12914DOI Listing

Comparison of micro-insulated needle radiofrequency and carbon dioxide laser ablation for the treatment of syringoma.

Dermatol Ther 2019 Apr 9:e12912. Epub 2019 Apr 9.

Department of Dermatology, National Medical Center, Seoul, Korea.

Syringoma is a benign adnexal tumor originating from the intradermal eccrine ducts and predominantly occurs in women at puberty or later in life. We present a case of a 30-year-old woman with a 2-year history of syringoma on her neck and axillar region. She was treated with two devices in a split manner. Read More

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http://dx.doi.org/10.1111/dth.12912DOI Listing
April 2019
1 Read

Treatment of recalcitrant squamous carcinoma in situ of penis with tapering imiquimod 5%-3,75% cream.

Dermatol Ther 2019 Apr 9:e12904. Epub 2019 Apr 9.

Dermatology Department, Department of Systems Medicine, University of Rome Tor Vergata, Viale Oxford, Rome, Italy.

Background: The efficacy of imiquimod as treatment of genital squamous carcinoma (SCC) is known and described in literature.

Objective: Evaluate the efficacy of tapering doses of imiquimod 5%-3,75% cream in the treatment of recalcitrant penis SCC in situ.

Methods: A patient with a SCC in situ received three cycles of therapy with imiquimod cream. Read More

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http://dx.doi.org/10.1111/dth.12904DOI Listing

Long pulse 1064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser in aesthetic dermatology.

Dermatol Ther 2019 Apr 9:e12907. Epub 2019 Apr 9.

Department of Dermatology, Mersin Medical Park Hospital, Mersin, Turkey.

Long pulse 1064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser is a very versatile laser due to its deep penetration and absorption by hemoglobin, melanin, and, water, which has gained increasing popularity over recent years for the treatment of leg veins and permanent hair removal as well as skin rejuvenation. The long-pulse Nd:YAG laser was appointed as treatment of choice for the treatment of 0.5-3. Read More

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http://dx.doi.org/10.1111/dth.12907DOI Listing

Treatment of severe psoriasis with ixekizumab in aliver transplant recipient with concomitant HBV infection.

Dermatol Ther 2019 Apr 9:e12909. Epub 2019 Apr 9.

Centre for the Study and Treatment of Psoriasis at the Department of Clinical Dermatology, San Gallicano Dermatological Institute, IRCCS, Via Elio Chianesi 53, 00144 Rome, Italy.

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http://dx.doi.org/10.1111/dth.12909DOI Listing

Severe forms of hidradenitis suppurativa with complications in the anogenital area.

Dermatol Ther 2019 Apr 9:e12910. Epub 2019 Apr 9.

IDI-IRCCS, via dei Monti di Creta 104, 00167, Rome, Italy.

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http://dx.doi.org/10.1111/dth.12910DOI Listing

Pyoderma Gangrenosum of the Vulva Treated with Mycophenolate Mofetil and Infliximab.

Dermatol Ther 2019 Apr 9:e12905. Epub 2019 Apr 9.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1111/dth.12905DOI Listing

JAK/STAT pathway modulation: Does it work in Dermatology?

Authors:
Özgür Gündüz

Dermatol Ther 2019 Apr 9:e12903. Epub 2019 Apr 9.

Kirikkale University Faculty of Medicine, Department of Dermatology and Venerology, Yenisehir District, Tahsin Duru Avenue, No:14, 71450, Yahsihan / Kirikkale, Turkey.

JAK/STAT is an intracellular signaling pathway, which plays a key role in downstream transmission of extracellular signals from cell membrane to the cell nucleus. This pathway is activated by cytokines, which participate in inflammation, innate and acquired immune responses, and also cell growth. Recent studies point out possible disturbances in JAK/STAT pathway in various inflammatory and autoimmune skin diseases, such as atopic dermatitis, psoriasis, alopecia areata. Read More

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http://dx.doi.org/10.1111/dth.12903DOI Listing

The use of 308 nm excimer lamp as a novel treatment for vulvar lichen simplex chronicus.

Dermatol Ther 2019 Apr 9:e12906. Epub 2019 Apr 9.

Dermatology department, Habib Thameur Hospital, Tunis, Tunisia.

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http://dx.doi.org/10.1111/dth.12906DOI Listing

Use of the Patient Benefit Index to monitor treatment of chronic spontaneous urticaria with omalizumab.

Dermatol Ther 2019 Apr 9:e12902. Epub 2019 Apr 9.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/dth.12902DOI Listing
April 2019
2 Reads

Hydroxychloroquine Combined With Superficial X-ray --A New Therapeutic Method In The Treatment Of Morphea Profunda.

Dermatol Ther 2019 Apr 9:e12896. Epub 2019 Apr 9.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

Morphea Profunda (MP) is a variant of Morphea that presents clinically as localized fbrotic plaques. Based on previous reports, there was no unified standard treatment for MP. Here we report a rare case of MP, which is the first report about treatment by hydroxychloroquine in combination with superficial X-ray. Read More

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http://dx.doi.org/10.1111/dth.12896DOI Listing

Hypersensitivity reaction to certolizumab pegol in a patient affected by psoriatic arthritis.

Dermatol Ther 2019 Apr 9:e12900. Epub 2019 Apr 9.

Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.

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http://dx.doi.org/10.1111/dth.12900DOI Listing

Successful treatment of one case of pemphigoid gestationis complicating with polycystic ovary syndrome.

Dermatol Ther 2019 Apr 8:e12898. Epub 2019 Apr 8.

Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Pemphigoid gestationis (PG) is a rare, autoimmune, subepidermal bullous dermatosis associated with pregnancy. It's mainly caused by autoantibodies against hemidesmosomal proteins - bullous pemphigoid 180, and usually presents in the second or third trimester of pregnancy sometimes exacerbates spontaneously after delivery. Here we reported a case of PG with polycystic ovary syndrome. Read More

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http://dx.doi.org/10.1111/dth.12898DOI Listing
April 2019
3 Reads
1.478 Impact Factor

Mission Impossible: Dermal Delivery of Growth factors VIA Microneedling.

Dermatol Ther 2019 Apr 8:e12897. Epub 2019 Apr 8.

Department of Dermatovenereology, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia.

The clinical application of transdermal delivery has been limited to lipophilic drugs with a molecular weight of less than 500 Da. The development of polymeric microneedles enabled the transdermal delivery of larger proteins and drugs. Extensive research has been conducted on the molecular size, solubility, pH, concentration and polarity of transdermal delivery; however, the maximal molecular weight for transdermal microneedle delivery has not been established. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12897
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http://dx.doi.org/10.1111/dth.12897DOI Listing
April 2019
1 Read

Generalized hypertrichosis due to secukinumab in a patient with moderate psoriasis: A case of serendipity or zemblanity?

Dermatol Ther 2019 Apr 8:e12894. Epub 2019 Apr 8.

Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, Italy.

After 4 months of therapy with secukinumab, a 67-year-old man with moderate psoriasis developed generalized hypertrichosis, along with PASI 90. The patient denied any drug intake, apart from secukinumab, nor applications of any creams. Moreover, this event did not really bother the patient, thus the therapy was not discontinued and the hypertrichosis is persisting as psoriasis' control. Read More

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http://dx.doi.org/10.1111/dth.12894DOI Listing
April 2019
1 Read

Biologics exposure during pregnancy and breastfeeding in a psoriasis patient.

Dermatol Ther 2019 Apr 8:e12895. Epub 2019 Apr 8.

Dermatology Clinic, Department Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Biologic agents have revolutionized the treatment of psoriasis, and the increasing use of these agents in women of childbearing age raises questions regarding pregnancy safety. We report a case of a woman affected with severe psoriasis, who underwent three pregnancies while exposed to biologic agents. Although immediately dismissed at first pregnancy awareness, first-trimester exposure occurred, and the course of the pregnancies was carefully monitored. Read More

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http://dx.doi.org/10.1111/dth.12895DOI Listing

Use of low-dose naltrexone in the treatment of severe hailey-hailey disease: one case report.

Dermatol Ther 2019 Apr 8:e12892. Epub 2019 Apr 8.

Department of Dermatology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

Introduction: Hailey-Hailey disease (HHD) or chronic benign familial pemphigus is an autosomal dominant genodermatosis with complete penetrance characterized by painful vesicles, erosions and macerated intertriginous skin.

Case Report: We present a 66-year-old woman with a personal 35-year history of pruritic recurrent vesicles and erosions in both axillae and inguinal folds. HHD was confirmed by cutaneous biopsy. Read More

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http://dx.doi.org/10.1111/dth.12892DOI Listing
April 2019
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Laser therapy for hair removal on grafts and flaps.

Dermatol Ther 2019 Apr 4:e12880. Epub 2019 Apr 4.

Hospital Universitario Fundación Alcorcón, Servicio de Dermatología, Madrid, 28922, España.

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http://dx.doi.org/10.1111/dth.12880DOI Listing
April 2019
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The impact of diabetes and metabolic syndromes to the effectiveness of cyclosporine a pharmacotherapy in psoriatic patients.

Dermatol Ther 2019 Apr 4:e12881. Epub 2019 Apr 4.

Department of Molecular Biology, School of Pharmacy with Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Sosnowiec, Poland.

Metabolic diseases concurrent with psoriasis may considerably affect the intensity of its symptoms and therapy efficacy. Cyclosporine A (CsA) is one of the medicines used in conventional therapy of psoriasis. The aim of the study was to determine whether Diabetes 2 and metabolic syndromes influence the efficacy of the CsA therapy in psoriatic patients. Read More

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http://dx.doi.org/10.1111/dth.12881DOI Listing
April 2019
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