155 results match your criteria Dermatologic Manifestations of Neurologic Disease


Post-acute Sequelae in COVID-19 Survivors: an Overview.

SN Compr Clin Med 2022 6;4(1):91. Epub 2022 Apr 6.

Union County College, Plainfield Campus, Plainfield, NJ USA.

In the acute phase of SARS-CoV-2 infection, varying degrees of clinical manifestations have been noticed in patients. Some patients who recovered from the infection developed long-term effects which have become of interest to the scientific and medical communities, as it relates to pathogenesis and the multidisciplinary approach to treatment. Long COVID (long-term or long-haul) is the collective term used to define recovered individuals of SARS-CoV-2 infection who have presented with persistent COVID symptoms, as well as the emergence of disorders and complications. Read More

View Article and Full-Text PDF

Neurological manifestations of long-COVID syndrome: a narrative review.

Ther Adv Chronic Dis 2022 17;13:20406223221076890. Epub 2022 Feb 17.

Second Department of Neurology, School of Medicine, 'Attikon' University Hospital, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece. Department of Neurology, The University of Tennessee Health Science Center, Memphis, TN, USA.

Accumulating evidence points toward a very high prevalence of prolonged neurological symptoms among coronavirus disease 2019 (COVID-19) survivors. To date, there are no solidified criteria for 'long-COVID' diagnosis. Nevertheless, 'long-COVID' is conceptualized as a multi-organ disorder with a wide spectrum of clinical manifestations that may be indicative of underlying pulmonary, cardiovascular, endocrine, hematologic, renal, gastrointestinal, dermatologic, immunological, psychiatric, or neurological disease. Read More

View Article and Full-Text PDF
February 2022

Presenting symptoms of leprosy at diagnosis: Clinical evidence from a cross-sectional, population-based study.

PLoS Negl Trop Dis 2021 11 23;15(11):e0009913. Epub 2021 Nov 23.

Yunnan Center for Disease Control and Prevention, Yunnan, China.

Background: Leprosy is associated with different dermatologic and neurologic manifestations within a wide clinical spectrum, causing a great diagnostic challenge. Therefore, we aimed to examine associations between common presenting symptoms of leprosy and stage at diagnosis.

Methodology/principal Findings: In this cross-sectional study, we analyzed population-level data from the Leprosy Management Information System (LEPMIS) in Yunnan, China, from 2010-2020 and enrolled patients with newly detected leprosy. Read More

View Article and Full-Text PDF
November 2021

COVID-19-related oral mucosa lesions among confirmed SARS-CoV-2 patients: a systematic review.

Int J Dermatol 2022 Jan 22;61(1):20-32. Epub 2021 Sep 22.

Department of Dermatology and Venereology, Koç University School of Medicine, İstanbul, Turkey.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for coronavirus disease 2019 (COVID-19), which manifests as a flu-like respiratory infection affecting multiple organ systems, including the gastrointestinal system, central nervous system, cardiovascular system, skin, and mucosa. In this review, we investigated the literature on specific manifestations of COVID-19 in the oral mucosa. An online literature search in PubMed, Scopus, Google Scholar, and Medline was conducted to retrieve relevant studies on confirmed COVID-19 patients with oral mucosa findings published between December 31, 2019, and April 07, 2021. Read More

View Article and Full-Text PDF
January 2022

Juvenile dermatomyositis in Thai children: Retrospective review of 30 cases from a tertiary care center.

Indian J Dermatol Venereol Leprol 2022 Mar-Apr;88(2):162-170

Division of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Juvenile dermatomyositis is a rare condition, but it is the most common idiopathic inflammatory myopathy in pediatric patients.

Aim: To study the clinical manifestations, investigations, treatment, clinical course, and outcomes of juvenile dermatomyositis in Thai children.

Method: This retrospective study included juvenile dermatomyositis patients treated at Siriraj Hospital, a 2,300-bed national tertiary referral center in Bangkok, Thailand, from 1994 to 2019. Read More

View Article and Full-Text PDF

Leonardo Da Vinci's Archival of the Dermatologic Condition.

Authors:
Edward Hadeler

J Med Humanit 2021 Dec 27;42(4):795-799. Epub 2021 Aug 27.

University of Miami, Miller School of Medicine, 1600 NW 10th Ave #1140, Miami, FL, USA.

The interconnection of scientific studies and art represented by Leonardo Da Vinci's (1452-1519) portraiture accentuates his role in documenting and archiving dermatologic conditions. His anatomical dissections, sketches, and paintings, including portraits, were all a means to observe, portray, and understand the nuances of the human body. In two of his most discussed portraits, Ginevra de' Benci (1474-1478) and Elisabetta del Giocondo, the Mona Lisa (1503-1506), Leonardo's execution of the exterior anatomy is so precise that he may have illustrated manifestations of disease that allow contemporary researchers to theorize diagnoses of dermatologic as well as neurologic, endocrine and vascular conditions. Read More

View Article and Full-Text PDF
December 2021

Inherent Dangers of Using Non-US Food and Drug Administration-Approved Substances of Abuse.

J Clin Pharmacol 2021 08;61 Suppl 2:S129-S141

Bertino Consulting, Schenectady, New York, USA.

Use of US Food and Drug Administration-approved substances of abuse has innate risks due to pharmacologic and pharmacokinetic properties of the medications, but the risk when using nonapproved drug products is much greater. Unbeknownst to the user, the dose of active ingredients in substances of abuse can vary substantially between different products because of manufacturing practices or improper storage. Even naturally occurring substances of abuse can have extensive dosage variability because of effects of the growing season and conditions, or differences in harvesting, storage, or manufacture of the finished products. Read More

View Article and Full-Text PDF

A systematic review of dermatologic manifestations among adult patients with COVID-19 diagnosis.

Skin Health Dis 2021 Jun 19;1(2):e20. Epub 2021 Mar 19.

Department of Dermatology Wake Forest Baptist Health Winston-Salem North Carolina USA.

Background: Infection with COVID-19 is characterized by respiratory, gastrointestinal and neurologic symptoms. However, limited evidence exists of the involvement of the integumentary system among COVID-19 patients and evidence suggests that these symptoms may even be the first presenting sign.

Objective: To systematically evaluate the literature published on dermatologic signs of COVID-19 in order to educate doctors about the dermatologic signs of COVID-19 infection. Read More

View Article and Full-Text PDF

Heterogeneous cutaneous findings associated with intrauterine HSV infection: A case series and literature review.

Pediatr Dermatol 2021 Jul 6;38(4):831-841. Epub 2021 Jul 6.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background/objective: Herpes simplex virus (HSV) infection acquired in utero may present with non-vesicular dermatologic findings in affected newborns, which may pose a diagnostic dilemma. We aimed to describe and assess the range of non-vesiculobullous skin lesions that neonates with intrauterine HSV infection may manifest at birth.

Methods: We collected a multicenter case series and conducted a literature review of neonates with intrauterine HSV infection presenting with non-vesiculobullous cutaneous lesions. Read More

View Article and Full-Text PDF

COVID-19 and the liver: A 2021 update.

Liver Int 2021 09 11;41(9):1988-1998. Epub 2021 Jul 11.

Division of Hepatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

In December 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China and has since resulted in a global pandemic in excess of 165 million reported infections and 3.4 million attributable deaths. COVID-19 is primarily a respiratory illness, which may be complicated by pneumonia and acute respiratory distress syndrome. Read More

View Article and Full-Text PDF
September 2021

Porphyria: awareness is the key to diagnosis!

Acta Clin Belg 2021 May 3:1-7. Epub 2021 May 3.

Department of General Internal Medicine, KU Leuven, Leuven, Belgium.

Porphyrias are disorders of the haem biosynthesis which are encountered infrequently and which often present themselves atypically as a combination of gastrointestinal, neurologic and/or dermatologic symptoms. Although they are primarily caused by enzyme defects, inheritance patterns are mostly not evident. Considering all of these characteristics, it is not surprising that there is a long delay between the onset of symptoms and the diagnosis of the disease, with as possible consequences impaired quality of life, irreversible neurologic damage and even death. Read More

View Article and Full-Text PDF

Clinical features of central nervous system involvement in patients with eosinophilic granulomatosis with polyangiitis: a retrospective cohort study in China.

Orphanet J Rare Dis 2021 03 31;16(1):152. Epub 2021 Mar 31.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, the Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China.

Background: Central nervous system (CNS) involvement is extremely rare in eosinophilic granulomatosis with polyangiitis (EGPA), but is associated with a poor prognosis in the five-factor score. This study aims to elucidate the clinical features and independently associated factors of EGPA with CNS involvement.

Results: CNS involvement was observed in 17. Read More

View Article and Full-Text PDF

[The 487th case: prominent eyes, headache, blurred vision].

Zhonghua Nei Ke Za Zhi 2021 Apr;60(4):388-392

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education,China National Clinical Research Center for Dermatologic and Immunologic Disease, Beijing 100730,China.

One 51 years old man was admitted to the rheumatology department with a history of prominent eyes, headache and blurred vision for half year. The main manifestations included retrobulbar inflammatory pseudotumor and retroperitoneal fibrosis. He was initially diagnosed as granulomatosis with polyangiitis. Read More

View Article and Full-Text PDF

Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China.

J Immunol Res 2021 18;2021:1349042. Epub 2021 Jan 18.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No. 1 Shuaifuyuan, Beijing 100730, China.

Objective: To identify the clinical characteristics, magnetic resonance imaging (MRI) results, and prognostic factors of neuropsychiatric (NP) systemic lupus erythematosus (SLE; NPSLE) in a relatively large patient series in China.

Methods: Data of patients with NPSLE at Peking Union Medical College Hospital (PUMCH) were collected retrospectively from June 2012 to June 2016. NPSLE patients were compared with 220 non-NPSLE patients. Read More

View Article and Full-Text PDF
October 2021

Adult-onset Still's disease with neurological involvement: a single-centre report.

Rheumatology (Oxford) 2021 09;60(9):4152-4157

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Objectives: Adult-onset Still's disease (AOSD) is a multifactorial systemic autoinflammatory disease. Neurological damage has been rarely reported in AOSD. We aimed to characterize the clinical features of AOSD patients with neurological involvement. Read More

View Article and Full-Text PDF
September 2021

Lyme Disease Pathogenesis.

Curr Issues Mol Biol 2021 23;42:473-518. Epub 2020 Dec 23.

Professor and Associate Head, Texas A and M University, 8447 Riverside Pkwy, Bryan, TX 77807, USA.

Lyme disease are obligately parasitic, tick- transmitted, invasive, persistent bacterial pathogens that cause disease in humans and non-reservoir vertebrates primarily through the induction of inflammation. During transmission from the infected tick, the bacteria undergo significant changes in gene expression, resulting in adaptation to the mammalian environment. The organisms multiply and spread locally and induce inflammatory responses that, in humans, result in clinical signs and symptoms. Read More

View Article and Full-Text PDF
November 2021

Identification of KRAS mutation in a patient with linear nevus sebaceous syndrome: a case report.

BMC Med Genomics 2020 12 12;13(1):188. Epub 2020 Dec 12.

Department of Dermatologic Surgery, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Jiangsu, China.

Background: Linear nevus sebaceous syndrome (LNSS) is a rare genetic disease characterized by large linear sebaceous nevus typically on the face, scalp, or neck. LNSS could be accompanied by multisystem disorders including the central nervous system. Herein, we report gene mutational profile via whole exome sequencing of both lesional and non-lesional skin samples in a LNSS patient. Read More

View Article and Full-Text PDF
December 2020

Incorporating joint pain screening into the pediatric dermatologic examination.

Pediatr Dermatol 2021 Jan 4;38(1):92-97. Epub 2020 Dec 4.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background/objectives: Joint manifestations are a feature of many pediatric skin disorders, among them psoriasis, autoimmune and autoinflammatory diseases, hypermobility disorders, and as an adverse effect of certain medications. Identifying joint disease early is important for intervention and prevention of chronic damage. However, pediatric musculoskeletal complaints are common and determining whether symptoms warrant a rheumatology referral for arthritis can be challenging. Read More

View Article and Full-Text PDF
January 2021

Extra-Gastric Manifestations of Infection.

J Clin Med 2020 Nov 30;9(12). Epub 2020 Nov 30.

Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy.

() is a Gram-negative flagellated microorganism that has been extensively studied since its first isolation due to its widespread diffusion and association with numerous diseases. While the bacterium is proved to be a causative factor for a number of gastric diseases such as gastritis, gastric adenocarcinoma, and MALT-lymphoma, its role at other gastrointestinal levels and in other systems is being thoroughly studied. In this article, we reviewed the latest published clinical and laboratory studies that investigated associations of with hematologic diseases such as Vitamin B12- and iron-deficiency anemia, primary immune thrombocytopenia, and with a number of dermatologic and ophthalmic diseases. Read More

View Article and Full-Text PDF
November 2020

Behçet's Disease: Different Systemic Manifestations at Different Ages.

Eurasian J Med 2020 Oct 2;52(3):304-306. Epub 2020 Jun 2.

Department of Pulmonary Disease, Ataturk University School of Medicine, Erzurum, Turkey.

Behçet's disease, an inflammatory condition, can involve various systems. The disease usually manifests with dermatologic and ocular signs but can also cause serious symptoms due to pulmonary or neurologic involvement. Although the onset may occur at any age, it typically emerges in the second to fourth decades of life. Read More

View Article and Full-Text PDF
October 2020

Multisystem Imaging Manifestations of COVID-19, Part 2: From Cardiac Complications to Pediatric Manifestations.

Radiographics 2020 Nov-Dec;40(7):1866-1892

From the Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, PO Box 208042, Room TE-2, New Haven, CT 06520 (M.V.R., A.M., A.S.B.); Department of Radiology, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Manhasset, NY (S.R., R.W., C.D., R.D.P., K.C., C.K., J.S.P.); and Department of Diagnostic Radiology, Danbury Radiological Associates, PC, Danbury, Conn (N.C.S.).

Infection with severe acute respiratory syndrome coronavirus 2 results in coronavirus disease 2019 (COVID-19), which was declared an official pandemic by the World Health Organization on March 11, 2020. COVID-19 has been reported in most countries, and as of August 15, 2020, there have been over 21 million cases of COVID-19 reported worldwide, with over 800 000 COVID-19-associated deaths. Although COVID-19 predominantly affects the respiratory system, it has become apparent that many other organ systems can also be involved. Read More

View Article and Full-Text PDF
November 2020

Rosai-Dorfman disease mimicking IgG4-related diseases: a single-center experience in China.

Orphanet J Rare Dis 2020 10 14;15(1):285. Epub 2020 Oct 14.

Departments of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China.

Background: Rosai-Dorfman disease (RDD) and IgG4-related (IgG4-RD) disease are both rare diseases, but in some cases, RDD mimics IgG4-RD clinically and pathologically. RDD mimicking IgG4-RDs (RDD mimic IgG4-RD), referring to disease initially diagnosed as IgG4-RD but finally pathologically confirmed to be RDD, is a clinically rare and confusing disease. To summarize the characteristics of this disease, we prospectively analyzed the clinical features, laboratory parameters, pathological characteristics, treatment and prognosis of patients diagnosed with RDD mimic IgG4-RD. Read More

View Article and Full-Text PDF
October 2020

Non-respiratory presentations of COVID-19, a clinical review.

Am J Emerg Med 2020 Nov 24;38(11):2444-2454. Epub 2020 Sep 24.

Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States. Electronic address:

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) is a highly infectious viral syndrome currently threatening millions of people worldwide. It is widely recognized as a disease of the pulmonary system, presenting with fever, cough, and shortness of breath. However, a number of extrapulmonary manifestations have been described in the literature. Read More

View Article and Full-Text PDF
November 2020

The Alzheimer patient from the dermatologist's point of view.

Ital J Dermatol Venerol 2021 08 7;156(4):422-427. Epub 2020 Oct 7.

Clinic of Dermatology, Department of Clinical-Surgical, Diagnostic and Pediatric Science, Foundation IRCCS Polyclinic San Matteo, University of Pavia, Pavia, Italy.

Alzheimer's disease (AD) is characterized by a cluster of signs and symptoms that include memory loss, language disturbances, psychological and psychiatric changes and difficulty in carrying out daily activities. Although it may seem to be far from a dermatologic competence, the ageing of populations in industrialized and developing countries has changed things, making AD a multidisciplinary question. Indeed, this neurodegenerative disorder is not exclusively neurological, but rather may involve multiple tissues and organs. Read More

View Article and Full-Text PDF

Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications.

Radiographics 2020 10;40(6):1574-1599

From the Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, PO Box 208042, Room TE-2, New Haven, CT 06520 (M.V.R., A.S.B., A.M.); Department of Radiology, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Manhasset, NY (S.R., R.W., C.D., R.D.P., K.C., C.K., J.S.P.); and Department of Diagnostic Radiology, Danbury Radiological Associates, PC, Danbury, Conn (N.C.S.).

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in coronavirus disease 2019 (COVID-19), which was declared an official pandemic by the World Health Organization on March 11, 2020. The infection has been reported in most countries around the world. As of August 2020, there have been over 21 million cases of COVID-19 reported worldwide, with over 800 000 COVID-19-associated deaths. Read More

View Article and Full-Text PDF
October 2020

Neurofibromatosis -1 diagnosed from an intraoral swelling - a case series.

Aust Dent J 2021 06 19;66(2):205-211. Epub 2020 Oct 19.

Dublin Dental University Hospital, Dublin, Ireland.

The neurofibromatoses [NF 1, NF 2 and schwannomatosis] are a group of genetic disorders that lead to the development of nervous system tumours and have diverse dermatologic, neurologic, ophthalmic, skeletal and vascular effects. The most common is NF 1 (Neurofibromatosis 1) also known as von Recklinghausen's disease, which is one of the most common human genetic diseases. Oral manifestations of NF 1 are reported in 72% of cases and in one of our cases precipitated attendance at a general dental practitioner (GDP), subsequent diagnosis and genetic screening for family members. Read More

View Article and Full-Text PDF

Extrapulmonary manifestations of COVID-19.

Nat Med 2020 07 10;26(7):1017-1032. Epub 2020 Jul 10.

Division of Nephrology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.

Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. Read More

View Article and Full-Text PDF