166 results match your criteria Dermatologic Manifestations of Hematologic Disease


Dermatologic Manifestations of the 1918-1919 Influenza Pandemic.

Skinmed 2019;17(5):296-297. Epub 2019 Sep 1.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA;

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Oral mucosal changes associated with primary diseases in other body systems.

Periodontol 2000 2019 06;80(1):28-48

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Systemic diseases may manifest in the oral cavity. This chapter reviews the oral mucosal pathology in blood diseases, gastrohepatic diseases, kidney diseases, immunologic and connective tissue diseases, endocrine diseases, pulmonary diseases, nutritional deficiencies, dermatologic diseases, as well as cancer-associated oral mucosal conditions. The oral mucosa is one of the most commonly affected tissues and may present with unique clinical appearances. Read More

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http://dx.doi.org/10.1111/prd.12265DOI Listing
June 2019
13 Reads

A Review of the Dermatologic Symptoms of Idiopathic Mast Cell Activation Syndrome

J Drugs Dermatol 2019 Feb;18(2):162-168

Since the first reported cases in 2007, idiopathic mast cell activation syndrome has been increasingly recognized. Understanding of the cutaneous manifestations of this condition is imperative for dermatologists given the substantial clinical heterogeneity in its presentation and high estimated prevalence. A review of PubMed® and SCOPUS® databases was performed in order to investigate the most common dermatologic manifestations of idiopathic mast cell activation syndrome. Read More

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February 2019
5 Reads

Cutaneous manifestations of hematologic malignancies the experience of an Italian dermatology department.

Hematol Oncol 2019 Aug 14;37(3):285-290. Epub 2018 Dec 14.

Di.S.Sal. Section of Dermatology, University of Genoa, San Martino Polyclinic Hospital, Genoa, Italy.

In recent years, dermatologic manifestations in oncohematologic patients have become more common. The aim of our study was to determine the incidence and heterogeneity of skin manifestations in patients followed at our Hematology Department. This observational monocentrical study was conducted on 60 patients. Read More

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http://dx.doi.org/10.1002/hon.2569DOI Listing
August 2019
22 Reads

Dietary Pyrophosphate Modulates Calcification in a Mouse Model of Pseudoxanthoma Elasticum: Implication for Treatment of Patients.

J Invest Dermatol 2019 05 20;139(5):1082-1088. Epub 2018 Nov 20.

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA. Electronic address:

Pseudoxanthoma elasticum is a heritable disease caused by ABCC6 deficiency. Patients develop ectopic calcification in skin, eyes, and vascular tissues. ABCC6, primarily found in liver and kidneys, mediates the cellular efflux of ATP, which is rapidly converted into inorganic pyrophosphate (PPi), a potent inhibitor of calcification. Read More

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http://dx.doi.org/10.1016/j.jid.2018.10.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478508PMC
May 2019
48 Reads

Uncommon immune-mediated extrahepatic manifestations of HCV infection.

Expert Rev Clin Immunol 2018 12 26;14(12):1089-1099. Epub 2018 Oct 26.

a Division of Internal Medicine, Department of Medical and Surgical Sciences , "Luigi Vanvitelli" University of Campania , Naples , Italy.

Introduction: Chronic hepatitis C virus (HCV) infection has been associated with myriad extrahepatic manifestations, often resulting from aberrant immune responses. Among the most common immune-mediated manifestations of HCV infection, mixed cryoglobulinemia is the best known extra-hepatic complication. Areas covered: Here we review less common extrahepatic manifestations of HCV infection, with ascertained or presumed immune pathogenesis and the role of the new all oral direct-acting antiviral agents. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1538790DOI Listing
December 2018
6 Reads

Angioinvasive fungal infections impacting the skin: Background, epidemiology, and clinical presentation.

J Am Acad Dermatol 2019 Apr 10;80(4):869-880.e5. Epub 2018 Aug 10.

Department of Dermatology and Pathology, University of Iowa, Iowa City, Iowa. Electronic address:

Angioinvasive fungal infections cause significant morbidity and mortality because of their propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia, infarct, and necrosis. While occasionally seen in immunocompetent hosts, opportunistic fungi are emerging in immunosuppressed hosts, including patients with hematologic malignancy, AIDS, organ transplant, and poorly controlled diabetes mellitus. The widespread use of antifungal prophylaxis has led to an "arms race" of emerging fungal resistance patterns. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.04.059DOI Listing
April 2019
29 Reads

Exploring relationships between joint hypermobility and neurodevelopment in children (4-13 years) with hereditary connective tissue disorders and developmental coordination disorder.

Am J Med Genet B Neuropsychiatr Genet 2018 09 2;177(6):546-556. Epub 2018 Aug 2.

Division of Medical Genetics, IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.

Joint hypermobility (JH) is a common, though largely ignored physical trait with increasing clinical reverberations. A few papers suggest a link between JH and selected neurodevelopmental disorders, such as developmental coordination disorder (DCD). JH is also the hallmark of various hereditary connective tissue disorders (HCTDs). Read More

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http://doi.wiley.com/10.1002/ajmg.b.32646
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http://dx.doi.org/10.1002/ajmg.b.32646DOI Listing
September 2018
15 Reads

Pattern of Use and Long-Term Safety of Tyrosine Kinase Inhibitors: A Decade of Real-World Management of Chronic Myeloid Leukemia.

Clin Drug Investig 2018 Sep;38(9):837-844

Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.

Background And Objectives: First-line treatment of chronic phase (CP) chronic myeloid leukemia (CML) is based on the first-generation tyrosine kinase inhibitor (TKI) imatinib or the second-generation TKIs dasatinib or nilotinib. Thanks to the efficacy of TKIs, CML has switched from a fatal to a 'chronic' pathology, and data from clinical trials have become insufficient to drive physicians' prescription choices and address long-term treatment outcomes. On the brink of commercialization of generic imatinib, this study aims to evaluate the therapeutic pattern of CP-CML and the occurrence of adverse events (AEs) over a decade of local real clinical practice. Read More

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http://dx.doi.org/10.1007/s40261-018-0676-7DOI Listing
September 2018
4 Reads

Cutaneous manifestations in Egyptian children with beta-thalassemia major: Relationship with serum ferritin, thyroid profile, and treatment modalities.

Pediatr Dermatol 2018 Sep 26;35(5):639-643. Epub 2018 Jun 26.

Departments of Dermatology, Venereology, and STDs, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Background: Cutaneous manifestations can be found in many patients with hematologic disorders, including thalassemia.

Methods: Patients with beta-thalassemia major attending the pediatric department of Fayoum University Hospital from April 2016 to October 2016 (n = 100) were compared with controls (n = 100). Both groups underwent detailed history evaluation, clinical examination, and laboratory investigations, including complete blood count, liver and kidney function, serum ferritin, and thyroid profile. Read More

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http://dx.doi.org/10.1111/pde.13570DOI Listing
September 2018
8 Reads

[A rare and atypical cause of scrotal ulcerations].

Pan Afr Med J 2018 30;29:87. Epub 2018 Jan 30.

Service de Dermatologie-Vénéréologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Salmonelloses are bacterial infections of the faecal peril; they are endemic in some regions of the world. They can colonize almost any organ hematogenously, hence, severe forms may be observed. We report a case of typhoid fever in a 16-year old young adolescent with no medical history, sexually transmitted diseases or sexual intercourses, presenting with necrotic scrotal ulcerations evolving over the past 3 weeks in a context of fever, diarrhoea, weight loss and alteration of the general state. Read More

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http://dx.doi.org/10.11604/pamj.2018.29.87.14511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987151PMC
June 2018
15 Reads

Unique causes of esophageal inflammation: a histopathologic perspective.

Ann N Y Acad Sci 2018 12 16;1434(1):219-226. Epub 2018 May 16.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

Gastroenterologists frequently perform endoscopic esophageal mucosal biopsies for pathologic diagnosis in patients experiencing symptoms of esophagitis. The more common causes of esophagitis diagnosed on esophageal mucosal biopsy include reflux esophagitis, eosinophilic esophagitis, and infectious esophagitis caused by Candida albicans, herpes simplex virus, and/or cytomegalovirus. However, there are several causes of esophagitis seen less frequently by pathologists that are very important to recognize. Read More

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http://dx.doi.org/10.1111/nyas.13732DOI Listing
December 2018
9 Reads

ABCC6 mutations and early onset stroke: Two cases of a typical Pseudoxanthoma Elasticum.

Eur J Paediatr Neurol 2018 Jul 12;22(4):725-728. Epub 2018 Apr 12.

Rare Disease Unit, Istituto Giannina Gaslini, Genoa, Italy.

Pseudoxanthoma elasticum (PXE) is a rare genetic disorder characterized by fragmented and mineralized elastic fibers in the mid-dermis of the skin, eye, digestive tract and cardiovascular system. Clinical presentation includes typical skin lesions, ocular angioid streaks, and multisystem vasculopathy. The age of onset varies considerably from infancy to old age, but the diagnosis is usually made in young adults due to frequent absence of pathognomonic skin and ocular manifestations in early childhood. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.04.002DOI Listing
July 2018
22 Reads
1.934 Impact Factor

Dermatological manifestations in hemodialysis patients in Iran: A systematic review and meta-analysis.

J Cosmet Dermatol 2019 Feb 25;18(1):204-211. Epub 2018 Mar 25.

Department of Basic and Clinical Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Dermatologic complications are common in patients with end-stage renal disease and also have a high diversity.

Objectives: This meta-analysis reviews prevalence of dermatological manifestations among hemodialysis patients in Iran.

Materials And Methods: Using PubMed and NLM Gateway (for MEDLINE), Institute of Scientific Information (ISI), and SCOPUS as the main international electronic data sources, and Iran-Medex, Irandoc, and Scientific Information Database, as the main domestic databases with systematic search capability, we systematically searched surveys, papers, and reports on the prevalence of dermatological manifestations (until February 2016). Read More

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http://doi.wiley.com/10.1111/jocd.12531
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http://dx.doi.org/10.1111/jocd.12531DOI Listing
February 2019
27 Reads

Erythroderma and extensive poikiloderma - a rare initial presentation of dermatomyositis: a case report.

J Med Case Rep 2018 Mar 24;12(1):83. Epub 2018 Mar 24.

National Hospital, Colombo, Sri Lanka.

Background: Dermatomyositis is a humoral-mediated inflammatory myopathy with symmetrical proximal muscle weakness and dermatological manifestations such as Gottron's papules, heliotrope rash, periungual abnormalities, and flagellate erythema. Erythroderma is a severe and potentially life-threatening dermatological condition with diffuse erythema and scaling involving more than 90% of the skin surface area. Poikiloderma vasculare atrophicans refers to mottled hyperpigmentation and hypopigmentation of the skin with in-between telangiectases and areas of atrophy and is considered a variant of mycosis fungoides. Read More

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http://dx.doi.org/10.1186/s13256-018-1618-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866516PMC
March 2018
8 Reads

Dermatologic Manifestations of Laparoscopic Port Site Vascular Injuries.

J Minim Invasive Gynecol 2019 01 9;26(1):16-17. Epub 2018 Mar 9.

Division of Minimally Invasive Gynecologic Surgery, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jmig.2018.03.004DOI Listing
January 2019
4 Reads

Pediatric leukemia susceptibility disorders: manifestations and management.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):242-250

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.

The clinical manifestations of inherited susceptibility to leukemia encompass a wide phenotypic range, including patients with certain congenital anomalies or early-onset myelodysplastic syndrome (MDS) and some with no obvious medical problems until they develop leukemia. Leukemia susceptibility syndromes occur as a result of autosomal dominant, autosomal recessive, or X-linked recessive inheritance, or de novo occurrence, of germline pathogenic variants in DNA repair, ribosome biogenesis, telomere biology, hematopoietic transcription factors, tumor suppressors, and other critical cellular processes. Children and adults with cytopenias, MDS, dysmorphic features, notable infectious histories, immunodeficiency, certain dermatologic findings, lymphedema, unusual sensitivity to radiation or chemotherapy, or acute leukemia with a family history of early-onset cancer, pulmonary fibrosis, or alveolar proteinosis should be thoroughly evaluated for a leukemia susceptibility syndrome. Read More

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http://dx.doi.org/10.1182/asheducation-2017.1.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142612PMC
December 2017
14 Reads

Imaging findings in systemic childhood diseases presenting with dermatologic manifestations.

Clin Imaging 2018 May - Jun;49:17-36. Epub 2017 Oct 31.

Department of Radiology, Division of Pediatric Radiology, Montefiore Medical Center, Bronx, NY, United States. Electronic address:

Purpose: Many childhood diseases often present with skin abnormalities with which radiologists are largely unfamiliar. Knowledge of associated dermatologic manifestations may aid the radiologist in confirming the diagnosis and recommending targeted imaging of affected organs.

Methods: We review the imaging findings in childhood diseases associated with dermatologic manifestations. Read More

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http://dx.doi.org/10.1016/j.clinimag.2017.10.015DOI Listing
September 2018
37 Reads

The skin as a window to the blood: Cutaneous manifestations of myeloid malignancies.

Blood Rev 2017 11 14;31(6):370-388. Epub 2017 Jul 14.

Department of Dermatology, Yale School of Medicine, New Haven, USA. Electronic address:

Cutaneous manifestations of myeloid malignancies are common and have a broad range of presentations. These skin findings are classified as specific, due to direct infiltration by malignant hematopoietic cells, or non-specific. Early recognition and diagnosis can have significant clinical implications, as skin manifestations may be the first indication of underlying hematologic malignancy, can reflect the immune status and stage of disease, and cutaneous reactions may occur from conventional and targeted agents used to treat myeloid disease. Read More

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http://dx.doi.org/10.1016/j.blre.2017.07.003DOI Listing
November 2017
36 Reads

Dermatologic Manifestations of Chronic Hepatitis C Infection.

Clin Liver Dis 2017 08 25;21(3):555-564. Epub 2017 Apr 25.

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA; Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA. Electronic address:

Chronic hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations, including dermatologic involvement mostly caused by immune complexes. Mixed cryoglobulinemia has a strong relationship with HCV with 95% of these patients being infected with HCV. Lichen planus is a disease of the squamous epithelium and may affect any part of the skin, with 4% to 24% of patients with lichen planus reported to have chronic HCV infection. Read More

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http://dx.doi.org/10.1016/j.cld.2017.03.010DOI Listing
August 2017
45 Reads

Paraneoplastic syndromes associated with gynecological cancers: A systematic review.

Gynecol Oncol 2017 09 24;146(3):661-671. Epub 2017 Jun 24.

Gynecologic Oncology Division, Centre Hospitalier Universitaire de Québec, L'Hôtel-Dieu de Québec, Université Laval 11 côte du Palais, Québec City, Québec G1R 2J6, Canada. Electronic address:

A number of paraneoplastic syndromes have been described with gynecological cancers. These syndromes are induced by substances secreted by the tumor or by an immune response triggered by the cancer. Each system of the human body can be affected by different syndromes. Read More

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http://dx.doi.org/10.1016/j.ygyno.2017.06.025DOI Listing
September 2017
9 Reads

Beyond the Bowel: Extraintestinal Manifestations of Inflammatory Bowel Disease.

Radiographics 2017 Jul-Aug;37(4):1135-1160. Epub 2017 May 26.

From the Department of Diagnostic Radiology (J.D.O., S.E.S., L.E.J., M.R., A.M.S.), University of Utah, 30 North 1900 East, #1A71, Salt Lake City, UT 84132; and the Department of Diagnostic Radiology, University of Wisconsin, Madison, Wis (B.P.S.).

Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated inflammation of the gastrointestinal tract. IBD includes two major disease entities: Crohn disease and ulcerative colitis. Imaging plays an important role in the diagnosis and surveillance of these complex disorders. Read More

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http://dx.doi.org/10.1148/rg.2017160121DOI Listing
November 2017
62 Reads

Cutaneous Manifestations of Medium- and Large-Vessel Vasculitis.

Clin Rev Allergy Immunol 2017 Dec;53(3):452-468

Université Pierre et Marie Curie-Paris VI, Assistance Publique-Hôpitaux de Paris, Service de Dermatologie-Allergologie, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.

Dermatologic manifestations are observed in almost all systemic vasculitides, even in large-and medium-vessel vasculitides, although such vessels are not found in the skin. Cutaneous manifestations may be related to a direct skin localization of the systemic vasculitis or a non-specific process associated with the vasculitis. According to the 2012 International Chapel Hill consensus, the two major variants of large-vessel vasculitides are Takayasu arteritis and giant-cell arteritis. Read More

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http://dx.doi.org/10.1007/s12016-017-8612-9DOI Listing
December 2017
21 Reads

Dermatologic manifestations of infective endocarditis.

An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):92-94

Universidade do Oeste Paulista (UNOESTE) - Presidente Prudente (SP), Brazil.

Despite advances in diagnosis and treatment, infective endocarditis still shows considerable morbidity and mortality rates. The dermatological examination in patients with suspected infective endocarditis may prove very useful, as it might reveal suggestive abnormalities of this disease, such as Osler's nodes and Janeway lesions. Osler's nodes are painful, purple nodular lesions, usually found on the tips of fingers and toes. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20164718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325006PMC
July 2017
32 Reads

Hepatitis C virus and its cutaneous manifestations: treatment in the direct-acting antiviral era.

J Eur Acad Dermatol Venereol 2017 Aug 29;31(8):1260-1270. Epub 2017 Mar 29.

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.

New all-oral direct-acting antivirals (DAA) have changed the hepatitis C virus (HCV) treatment landscape. Given that dermatologists frequently encounter HCV-infected patients, knowledge of the current treatment options and their utility in treating HCV-associated dermatologic disorders is important. In addition to highlighting the new treatment options, we review four classically HCV-associated dermatologic disorders - mixed cryoglobulinaemia (MC), lichen planus (LP), porphyria cutanea tarda (PCT) and necrolytic acral erythema (NAE) - and examine the role for all-oral direct-acting antiviral (DAA) regimens in their treatment. Read More

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http://dx.doi.org/10.1111/jdv.14186DOI Listing
August 2017
14 Reads

Dermatologic Manifestations of Monogenic Autoinflammatory Diseases.

Dermatol Clin 2017 Jan;35(1):21-38

Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Building 10, Room 6D-47B, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address:

Autoinflammatory disorders are sterile inflammatory conditions characterized by episodes of early-onset fever, rash, and disease-specific patterns of organ inflammation. Gain-of-function mutations in innate danger-sensing pathways, including the inflammasomes and the nucleic acid sensing pathways, play critical roles in the pathogenesis of IL-1 and Type-I IFN-mediated disorders and point to an important role of excessive proinflammatory cytokine signaling, including interleukin (IL)-1b , Type-I interferons, IL-18, TNF and others in causing the organ specific immune dysregulation. The article discusses the concept of targeting proinflammatory cytokines and their signaling pathways with cytokine blocking treatments that have been life changing for some patients. Read More

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http://dx.doi.org/10.1016/j.det.2016.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147585PMC
January 2017
47 Reads
2 Citations
1.434 Impact Factor

Leukemia Cutis: A Report of 17 Cases and a Review of the Literature.

Actas Dermosifiliogr 2016 Nov 20;107(9):e65-e69. Epub 2016 May 20.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España; Universidad de Valencia, Valencia, España.

Dermatologic manifestations of leukemia can be both specific and nonspecific (e.g., opportunistic infections, purpura and ecchymosis, Sweet syndrome). Read More

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http://dx.doi.org/10.1016/j.ad.2016.02.015DOI Listing
November 2016
8 Reads

Therapeutic Apheresis in Hematologic, Autoimmune and Dermatologic Diseases With Immunologic Origin.

Ther Apher Dial 2016 Oct 16;20(5):433-452. Epub 2016 Sep 16.

Inselklinik Heringsdorf GmbH, 17424, Seeheilbad Heringsdorf, Germany.

The process of curing a patient by removing his illness by extracting blood is a very old one. Many years ago, phlebotomy was practiced to cure illness. Now, this old process, placed on a rational basis with therapeutic apheresis (TA), is being followed in clinical practice. Read More

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http://dx.doi.org/10.1111/1744-9987.12474DOI Listing
October 2016
31 Reads

Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency.

Nutr Clin Pract 2017 Apr 5;32(2):275-276. Epub 2016 Oct 5.

1 Department of Dermatology, Charles Nicolle Hospital, University of Tunis El Manar, Tunis, Tunisia.

Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Read More

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http://doi.wiley.com/10.1177/0884533616670380
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http://dx.doi.org/10.1177/0884533616670380DOI Listing
April 2017
23 Reads

The clinical spectrum of kaposiform hemangioendothelioma and tufted angioma.

Semin Cutan Med Surg 2016 Sep;35(3):147-52

Department of Pediatrics, Division of Dermatology, Seattle Children's Hospital/University of Washington School of Medicine, Seattle, Washington, USA.

Kasposiform hemoangioendothelioma (KHE) and tufted angioma (TA) are classifed as vascular tumors with locally aggressive and benign growth potential, respectively, within the classification schema proposed by the International Society for the Study of Vascular Anomalies. A unique feature of these vascular tumors is the risk of Kasabach-Merritt phenomenon (KMP), a severe thrombocytopenia with mild to moderate coagulopathy resulting from intralesional platelet trapping. As with many vascular anomalies, accurate description of clinical course, responses to therapy, and long-term outcomes have been hindered by lesion misidentification, imprecise nomenclature, and lack of prospective, randomized clinical trials to assess therapeutic efficacy. Read More

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http://dx.doi.org/10.12788/j.sder.2016.048DOI Listing
September 2016
24 Reads

Monoclonal gammopathy of cutaneous significance: review of a relevant concept.

Authors:
D Lipsker

J Eur Acad Dermatol Venereol 2017 Jan 8;31(1):45-52. Epub 2016 Aug 8.

Faculté de Médecine, Université de Strasbourg et Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Some dermatologic entities are strongly associated with the presence of a monoclonal gammopathy. They should be referred to as monoclonal gammopathy of cutaneous significance (MGCS). A short review of the main entities that fit into the spectrum of MGCS is provided. Read More

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http://dx.doi.org/10.1111/jdv.13847DOI Listing
January 2017
107 Reads

Amyopathic Dermatomyositis: A Concise Review of Clinical Manifestations and Associated Malignancies.

Am J Clin Dermatol 2016 Oct;17(5):509-518

Department of Dermatology, University of California San Diego, 10991 Twinleaf Court, San Diego, CA, 92131, USA.

Amyopathic dermatomyositis is a rare, idiopathic, connective tissue disease that presents with dermatologic lesions of classic dermatomyositis but lacks the myopathy of this disease. Cutaneous manifestations may include Gottron's sign, heliotrope rash, and characteristic patterns of poikiloderma. There is a substantial risk for developing interstitial lung disease or malignancy in patients with amyopathic dermatomyositis. Read More

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http://dx.doi.org/10.1007/s40257-016-0199-zDOI Listing
October 2016
24 Reads

Clinical Features and Treatment Outcomes of Patients With Necrobiotic Xanthogranuloma Associated With Monoclonal Gammopathies.

Clin Lymphoma Myeloma Leuk 2016 08 5;16(8):447-52. Epub 2016 May 5.

Divisions of Hematology and Blood and Marrow Transplantation, Mayo Clinic, Rochester, MN. Electronic address:

Introduction: Necrobiotic xanthogranuloma (NXG) is a rare chronic granulomatous disorder of the skin associated with a monoclonal gammopathy.

Patients And Methods: The present report describes the findings from a single tertiary medical center retrospective study, including the clinical features of 35 patients with NXG and monoclonal gammopathy from 2000 to 2015 and their subsequent disease course and treatment response. The median age at diagnosis was 56 years (range, 26-88 years). Read More

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http://dx.doi.org/10.1016/j.clml.2016.04.009DOI Listing
August 2016
54 Reads

Cutaneous manifestations of multiple myeloma and other plasma cell proliferative disorders.

Semin Oncol 2016 06 23;43(3):395-400. Epub 2016 Feb 23.

Plasma Cell Disorders Program, Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC. Electronic address:

Plasma cell proliferative disorders cause rare but extremely varied dermatologic manifestations that may occur as an accompaniment to established diagnoses, or may be a first clue of an underlying neoplasm in the setting of clinical suspicion. In some instances skin lesions result from aggregation of misfolded monoclonal immunoglobulins or their fragments, as in light chain-related systemic amyloidosis. On other occasions the cutaneous lesions result from deposits of malignant plasma cells or monoclonal proteins. Read More

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http://dx.doi.org/10.1053/j.seminoncol.2016.02.017DOI Listing
June 2016
15 Reads

Image Gallery: Dermatologic and retinal manifestations of pseudoxanthoma elasticum.

Br J Dermatol 2016 Apr;174(4):e21

Bascom Palmer Eye Institute, Anne Bates Leach Eye Hospital, University of Miami Miller School of Medicine, Miami, FL, 33136, U.S.A.

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http://dx.doi.org/10.1111/bjd.14439DOI Listing
April 2016
5 Reads

Hoyeraal-Hreidarsson Syndrome: An Extremely Rare Dyskeratosis Congenita Phenotype.

Pediatr Dermatol 2015 Nov-Dec;32(6):e263-6. Epub 2015 Oct 8.

Division of Pediatric Genetics, Department of Pediatrics, School of Medicine, Acibadem University, Istanbul, Turkey.

Hoyeraal-Hreidarsson syndrome is a rare telomere biology disorder that is recognized as a severe variant of dyskeratosis congenita. We present a Libyan boy with hematologic and neurologic abnormalities with typical dermatologic manifestations of dyskeratosis congenita. Death usually occurs before the age of 4 years as a result of pancytopenia or malignant transformation of mucocutaneous lesions. Read More

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http://dx.doi.org/10.1111/pde.12693DOI Listing
September 2016
15 Reads

Essential Thrombocythemia: The Dermatologic Point of View.

Clin Lymphoma Myeloma Leuk 2015 Dec 3;15(12):739-47. Epub 2015 Sep 3.

Di. S. Sal. Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria, San Martino-IST, Genoa, Italy.

Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by an increase in blood platelets and dominated by a predisposition to vascular events. Cutaneous manifestations can complicate its course. itching has been the most common symptom reported; however, the percentage has ranged from 3% to 46%, depending on the survey. Read More

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http://dx.doi.org/10.1016/j.clml.2015.08.086DOI Listing
December 2015
51 Reads

Dermatologic Manifestations in End-stage Renal Disease.

Iran J Kidney Dis 2015 Sep;9(5):339-53

Division of General Internal Medicine, Toronto General Hospital, University of Toronto, Toronto, Canada.

End-stage renal disease (ESRD) is a rapidly growing global health problem within the past decades due to increased life expectancy, diabetes mellitus, hypertension, and vascular diseases. Since ESRD is not curable definitively, patients suffering from ESRD have a very low quality of life; therefore, symptomatic management is the cornerstone of medical treatment. Uremia affects almost all body organs, such as skin, through different mechanisms including biochemical, vascular, neurologic, immunologic, hematologic, endocrine, and electrolyte and volume balance disturbances. Read More

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September 2015
66 Reads

Possible Role of Interleukin-31/33 Axis in Imatinib Mesylate-Associated Skin Toxicity.

Turk J Haematol 2015 Jun;32(2):168-71

University of Messina Faculty of Medicine, Department of General Surgery and Oncology, Division of Hematology, Messina, Italy Phone: 0039 090 221 23 64 E-mail:

Imatinib mesylate is a small-molecule tyrosine kinase inhibitor (TKi) designed to target c-ABL and BCR-ABL, approved for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors. Adverse cutaneous reactions induced by imatinib are frequent, generally moderate, and dose-dependent. The aim of this work was to investigate the possible contribution of interleukin (IL)-33 and IL-31, cytokines involved in disorders associated with itching, in the pathogenesis of pruritus in a patient undergoing imatinib mesylate treatment. Read More

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http://dx.doi.org/10.4274/tjh.2014.0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451486PMC
June 2015
20 Reads

Spectrum of Eosinophilic End-Organ Manifestations.

Immunol Allergy Clin North Am 2015 Aug 17;35(3):403-11. Epub 2015 Jun 17.

Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

Eosinophil-associated disorders can affect practically all tissues and organs in the body, either individually or in combination. This article provides an overview of end-organ manifestations of eosinophilia and discusses selected organ systems, including the upper and lower respiratory, cardiovascular, gastrointestinal, nervous, dermatologic, and renal systems. Mechanisms by which eosinophilia leads to end-organ damage are also considered. Read More

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http://dx.doi.org/10.1016/j.iac.2015.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515759PMC
August 2015
17 Reads

Dermatologic Diagnosis: Leukocytoclastic Vasculitis.

Perm J 2015 ;19(3):77-8

Senior Emergency Physician at the Santa Clara Medical Center, and Clinical Assistant Professor of Emergency Medicine (Surgery) at Stanford University. He is the Medical Director for the Foothill College Paramedic Program in Los Altos, CA.

Leukocytoclastic vasculitis (LCV), also termed hypersensitivity vasculitis, is a small-vessel vasculitis. The skin is the organ most commonly involved in LCV. Typical presentation is a painful, burning rash predominantly in the lower extremities. Read More

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http://dx.doi.org/10.7812/TPP/15-001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500485PMC
April 2016
10 Reads

Acute visual loss following dapsone-induced methemoglobinemia and hemolysis.

Clin Toxicol (Phila) 2015 Jun 10;53(5):489-92. Epub 2015 Apr 10.

Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain , Brussels , Belgium.

Objective: While methemoglobinemia is a possible complication of chronic dapsone therapy or of acute overdose, serious adverse manifestations related to methemoglobin formation remain rare. We present an unusual case with severe ischemic retinal injury.

Case Report: A 30-year-old African woman presented with a sudden decrease of visual acuity secondary to retinal ischemia. Read More

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http://dx.doi.org/10.3109/15563650.2015.1033631DOI Listing
June 2015
10 Reads

Epstein-Barr virus: dermatologic associations and implications: part I. Mucocutaneous manifestations of Epstein-Barr virus and nonmalignant disorders.

J Am Acad Dermatol 2015 Jan;72(1):1-19; quiz 19-20

Cooper Medical School of Rowan University, Camden, New Jersey; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Epstein-Barr virus (EBV) is a ubiquitous virus that has been implicated in a wide range of human diseases, many of which have mucocutaneous manifestations. As a member of the herpesviridae family, EBV causes lifelong infection by establishing latency in B lymphocytes. An intact immune response is critical in preventing progression of EBV disease, and the clinical manifestations of infection are dependent on the intricate relationship between virus and host immune system. Read More

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http://dx.doi.org/10.1016/j.jaad.2014.07.034DOI Listing
January 2015
53 Reads

Differences in Comorbidity Profiles between Early-Onset and Late-Onset Alopecia Areata Patients: A Retrospective Study of 871 Korean Patients.

Ann Dermatol 2014 Dec 26;26(6):722-6. Epub 2014 Nov 26.

Department of Dermatology, Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Background: Alopecia areata (AA) is a common dermatologic condition with a broad spectrum of clinical features and age of onset, classically characterized by nonscarring patches of hair loss. In the past, early-onset (before adolescence) AA has been associated with various autoimmune diseases, especially atopic diseases and lupus erythematosus and demonstrates a worse prognosis compared with late onset AA.

Objective: To evaluate the differences in the comorbidity profile of AA with regard to age at onset. Read More

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http://dx.doi.org/10.5021/ad.2014.26.6.722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252669PMC
December 2014
22 Reads

The lymphoid variant of hypereosinophilic syndrome: study of 21 patients with CD3-CD4+ aberrant T-cell phenotype.

Medicine (Baltimore) 2014 Oct;93(17):255-66

Institut d'Immunologie, Réseau Eosinophile, EA2686 (GL, FL, DL, ML, JT, JEK), Service d'Immunologie Clinique et de Médecine Interne, Centre de Référence Maladies Auto-Immunes Systémiques (GL, DL, LT, NLG, PYH), Institut de Pathologie (MCC), Service de Dermatologie (DSS), Service des Maladies du Sang (FM), Institut de Génétique Médicale, U837 Inserm (CRL), Réseau Eosinophile, U995 Inserm (MC), CHRU de Lille, Université Lille Nord de France, Lille; Service de Dermatologie (MAA, CL), CHU d'Angers, L'UNAM Université, Angers; Service de Dermatologie et Dermatologie Pédiatrique, Centre de Référence pour les Maladies Rares de la Peau, U1035 (AT), CHU de Bordeaux, Bordeaux; Service d'Hématologie (GS) and Service de Radiologie, CREATIS, UMR5220 CNRS, U1044 Inserm (FC), Hôpital Sud, Service de Pneumologie, Centre de Référence pour les Maladies Pulmonaires Rares (CK), Hospices Civils de Lyon, Université Claude Bernard Lyon I, Lyon; Service d'Onco-Hématologie (HM), Centre Hospitalier de La Roche-Sur-Yon, La Roche-Sur-Yon; Service d'Onco-Hématologie (KG), Centre Hospitalier de Beauvais, Beauvais; Service de Médecine Interne (FA), Hôpital Bicêtre, APHP, Université Paris Sud XI, Le Kremlin-Bicêtre; Service d'Hématologie et Immunologie Pédiatrique (AB), Hôpital Robert Debré, APHP, Université Paris Diderot and Service de Pneumologie A, Centre de Compétence Maladies Pulmonaires Rares (RB), Hôpital Bichat, APHP, Paris; Service de Médecine Interne (CMH), Centre Hospitalier d'Annecy, Annecy; Service de Médecine Interne, Hôpital Foch, Suresne; EA4340, Biomarqueurs en Cancérologie et en Onco-Hématologie, Université Versailles-Saint-Quentin-en-Yvelines (JEK), France.

The CD3-CD4+ aberrant T-cell phenotype is the most described in the lymphoid variant of hypereosinophilic syndrome (L-HES), a rare form of HES. Only a few cases have been reported, and data for these patients are scarce. To describe characteristics and outcome of CD3-CD4+ L-HES patients, we conducted a national multicentric retrospective study in the French Eosinophil Network. Read More

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http://dx.doi.org/10.1097/MD.0000000000000088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602413PMC
October 2014
77 Reads

Mucocutaneous manifestations of inflammatory bowel disease in Turkey.

J Cutan Med Surg 2014 Nov;18(6):397-404

Background: Mucocutaneous manifestations of inflammatory bowel diseases are relatively common; the mean incidence is around 10% at the time of diagnosis. However, during follow-up, an increased variety of skin lesions, granulomatous cutaneous disease, reactive skin eruptions, nutritional defiencies, and other associated conditions may develop.

Objective: The objective of this study was to evaluate the prevalence of the mucocutaneous manifestations and their association with gender, duration of disease, arthritis, location of the bowel disease, and disease activity. Read More

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http://journals.sagepub.com/doi/ 10.2310/7750.2014.13209
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http://dx.doi.org/10.2310/7750.2014.13209DOI Listing
November 2014
15 Reads

Common dermatologic manifestations of primary immune deficiencies.

Curr Allergy Asthma Rep 2014 Dec;14(12):480

Division of Allergy/Immunology/Pediatric Rheumatology, Department of Pediatrics, Women and Children's Hospital of Buffalo, SUNY at Buffalo School of Medicine and Biomedical Sciences, 219 Bryant Street, Buffalo, NY, 14222, USA.

The skin is the largest organ of our body; it consists of the epidermis, dermis, hair follicles, sweat glands, blood vessels, and connective tissue matrix. Its main function is to act as a barrier to the outside world and protect us from infections. Any component of the skin is subject to insults from the environment and/or from within the body. Read More

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http://dx.doi.org/10.1007/s11882-014-0480-2DOI Listing
December 2014
22 Reads

Extraintestinal manifestations of Helicobacter pylori: a concise review.

World J Gastroenterol 2014 Sep;20(34):11950-61

Frank Wong, Erin Rayner-Hartley, Michael F Byrne, Division of Gastroenterology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

Helicobacter pylori (H. pylori) infection has been clearly linked to peptic ulcer disease and some gastrointestinal malignancies. Increasing evidence demonstrates possible associations to disease states in other organ systems, known as the extraintestinal manifestations of H. Read More

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http://dx.doi.org/10.3748/wjg.v20.i34.11950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161781PMC
September 2014
39 Reads

Histopathologic spectrum of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): a diagnosis that needs clinico-pathological correlation.

G Ital Dermatol Venereol 2014 Jun;149(3):291-300

Department of Clinical‑Surgical, Diagnostic and Pediatric Sciences Dermatology Section, University of Pavia Foundation IRCCS Policlinico San Matteo, Pavia, Italy -

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is characterized by an heterogeneous group of severe dermatologic manifestations and systemic involvement, due to several groups of medicaments. A series of 9 consecutive cases, observed from 2008 to 2013 in the Department of Dermatology, University of Pavia, is reported, all satisfying the clinical, hematological and systemic diagnostic criteria of DRESS. Clinically, 4 out of 9 patients had an urticarial and papular eruption, 2 an erythema-multiforme-like (EM-like) pattern, 2 erythroderma and 1 had an erythematous and macular reaction. Read More

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June 2014
15 Reads

The spectrum of oculocutaneous disease: Part II. Neoplastic and drug-related causes of oculocutaneous disease.

J Am Acad Dermatol 2014 May;70(5):821.e1-19

Baylor University Medical Center, Dallas, Texas. Electronic address:

There are a multitude of diseases that commonly affect both the skin and the eye. Part II of this 2-part series reviews the oculocutaneous manifestations of neoplasms, both benign and malignant, and adverse drug reactions affecting the skin and the eye. Though rare, a number of neoplasms that primarily involve the skin, such as melanoma and basal cell carcinoma, can metastasize to the eye, leading to permanent damage if not properly treated. Read More

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http://dx.doi.org/10.1016/j.jaad.2013.12.019DOI Listing
May 2014
41 Reads