138 results match your criteria Dermatologic Manifestations of Gastrointestinal Disease


Monogenic Primary Immunodeficiency Disorder Associated with Common Variable Immunodeficiency and Autoimmunity.

Int Arch Allergy Immunol 2020 Jul 2:1-9. Epub 2020 Jul 2.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran,

Background: Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency disorder mainly characterized by recurrent bacterial infections besides other immunological defects including loss of or dysfunction of B cells and decreased immunoglobulin levels. In this study, our aim is to evaluate clinical, immunological, and molecular data of patients with a primary clinical diagnosis of CVID and autoimmune phenotype with a confirmed genetic diagnosis.

Methods: Among 297 patients with CVID, who were registered in the Iranian Primary Immunodeficiency Registry at Children's Medical Center Hospital in Iran, 83 patients have been genetically examined and 27 patients with autoimmunity and confirmed genetic mutations were selected for analysis. Read More

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http://dx.doi.org/10.1159/000508817DOI Listing
July 2020
2.673 Impact Factor

Multisystem Inflammatory Syndrome in Children in New York State.

N Engl J Med 2020 Jun 29. Epub 2020 Jun 29.

From the New York State Department of Health, Albany (E.M.D., A.M., J.R., A.M.M., D.E., J.K., W.P., L.S., B.H., D.B., H.Z.); the Centers for Disease Control and Prevention (CDC) COVID-19 Response (E.H.K., E.J.C.) and the Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services (E.J.C.), CDC, Atlanta; and the University at Albany School of Public Health, State University of New York, Rensselaer (E.M.R., M.A.B., E.S.R., T.U.).

Background: A multisystem inflammatory syndrome in children (MIS-C) is associated with coronavirus disease 2019. The New York State Department of Health (NYSDOH) established active, statewide surveillance to describe hospitalized patients with the syndrome.

Methods: Hospitals in New York State reported cases of Kawasaki's disease, toxic shock syndrome, myocarditis, and potential MIS-C in hospitalized patients younger than 21 years of age and sent medical records to the NYSDOH. Read More

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http://dx.doi.org/10.1056/NEJMoa2021756DOI Listing

Clinical manifestations of Behçet's disease in a large cohort of Chinese patients: gender- and age-related differences.

Clin Rheumatol 2020 May 11. Epub 2020 May 11.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.

Objectives: To investigate the clinical characteristics of Bechet's disease (BD) with respect to gender and age in China.

Method: Clinical data of 489 BD patients admitted to Peking Union Medical College Hospital (PUMCH) and registered by the BD registry database established by PUMCH from March 2014 to January 2019 were collected and analyzed in this study. Demographics, medical histories, clinical manifestations, laboratory test results, imaging findings, assessment of disease activity, treatment regimen, as well as the outcomes were reviewed. Read More

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http://dx.doi.org/10.1007/s10067-020-05026-2DOI Listing
May 2020
1.774 Impact Factor

Gastric Cardia Adenocarcinoma with Metastasis to the Scalp: A Case Report.

Cureus 2020 Jan 27;12(1):e6781. Epub 2020 Jan 27.

Oncology, University of Arizona Cancer Center, Tucson, USA.

Cutaneous metastasis is a rare manifestation of advanced gastrointestinal (GI) cancers. Gastric adenocarcinoma rarely presents with cutaneous metastasis, as cutaneous manifestations occur in less than 1% of upper GI tract malignancies. Here, we present the case of a patient with advanced gastric cardia adenocarcinoma with metastasis to the right occipital region of the scalp. Read More

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http://dx.doi.org/10.7759/cureus.6781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045980PMC
January 2020

Metastatic vulvar Crohn's disease preceding intestinal manifestations: a case report and short review.

Acta Dermatovenerol Alp Pannonica Adriat 2019 Sep;28(3):131-133

Department of Dermatology, University General Hospital of Patras, Patras, Greece.

Crohn's disease (CD) is a multi-systemic chronic granulomatous inflammatory disease with a constellation of extraintestinal manifestations affecting various organs, including the skin. Metastatic CD (MCD), defined as granulomatous lesions of the skin occurring at sites separate from the gastrointestinal (GI) tract in patients affected with CD, is the least common cutaneous manifestation, and it is occasionally the primary manifestation of the disease. It may precede any symptoms from the GI tract by months or even years, and it often remains undiagnosed. Read More

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September 2019
1 Read

[Dermatologic Manifestations in Inflammatory Bowel Disease].

Korean J Gastroenterol 2019 May;73(5):285-293

Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea.

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract with an unknown etiology and pathogenesis. The incidence and prevalence of IBD are increasing rapidly in Korea. Approximately one-third of patients with IBD appear to develop extra-intestinal manifestations with the skin being one of the most commonly affected organs. Read More

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http://dx.doi.org/10.4166/kjg.2019.73.5.285DOI Listing
May 2019
8 Reads

[Cheilitis granulomatosa revealing Crohn's disease].

Pan Afr Med J 2018 20;30:147. Epub 2018 Jun 20.

Service d'Hépato-gastroentérologie, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohammed Ben Abdellah, Fès, Maroc.

Many disorders of the digestive tract cause cutaneous manifestations that may be an indication of an underlying condition; hence dermatologist plays a key role in recommending that the patient see a gastroenterologist. Conversely, gastroenterologist often sees patients with mucocutaneous lesions suggesting possible association with well-known digestive disorders. Chronic inflammatory bowel diseases are the typical example of this essential collaboration between the two specialities. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.147.5395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201612PMC
November 2018
19 Reads

Clinical outcomes and feasibility of the multidisciplinary management of patients with psoriatic arthritis: two-year clinical experience of a dermo-rheumatologic clinic.

Clin Rheumatol 2018 Oct 29;37(10):2741-2749. Epub 2018 Jul 29.

Clinica Medica, Dipartimento Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Via Tronto 10/A, 60126, Ancona, Italy.

Psoriatic arthritis (PsA) is a chronic inflammatory autoimmune arthritis, occurring in patients with psoriasis (Pso), that may affect the whole musculoskeletal system but also nails, eye, and gastrointestinal tract. Dermatologists and rheumatologists usually manage Pso and PsA separately, but early diagnosis and integrated management could achieve better outcomes of both skin and musculoskeletal manifestations, thus improving the health-related quality of life (HRQoL) of patients. In this work, we have described a model of integrated dermo-rheumatologic approach for the early diagnosis of PsA and to present the outcomes of the multidisciplinary management of PsA patients after 48 weeks of follow-up. Read More

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http://dx.doi.org/10.1007/s10067-018-4238-4DOI Listing
October 2018
16 Reads

Dermatologic Manifestations of Colchicine Intoxication.

Pediatr Emerg Care 2018 Jul;34(7):e131-e133

Department of Pediatrics, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.

Colchicine is an anti-inflammatory drug that has a narrow therapeutic index. Poisoning typically shows 3 phases with systemic symptoms. Gastrointestinal symptoms dominate in the first phase. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001530DOI Listing
July 2018
68 Reads

Dermatologic manifestations of inflammatory bowel disease: a review.

Discov Med 2018 05;25(139):225-233

Department of Dermatopathology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.

Inflammatory bowel disease (IBD) is a chronic relapsing disease of the gastrointestinal tract with unknown etiology and pathogenesis. It includes Crohn's disease (CD) and ulcerative colitis (UC). Approximately one-third of the patients with IBD are seen to develop extraintestinal manifestations, among which cutaneous manifestations are the most common and should be managed in close collaboration with a dermatologist. Read More

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May 2018
10 Reads

Unique causes of esophageal inflammation: a histopathologic perspective.

Ann N Y Acad Sci 2018 12 16;1434(1):219-226. Epub 2018 May 16.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

Gastroenterologists frequently perform endoscopic esophageal mucosal biopsies for pathologic diagnosis in patients experiencing symptoms of esophagitis. The more common causes of esophagitis diagnosed on esophageal mucosal biopsy include reflux esophagitis, eosinophilic esophagitis, and infectious esophagitis caused by Candida albicans, herpes simplex virus, and/or cytomegalovirus. However, there are several causes of esophagitis seen less frequently by pathologists that are very important to recognize. Read More

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http://dx.doi.org/10.1111/nyas.13732DOI Listing
December 2018
9 Reads

Dermatological Manifestations in Pediatric Patients with Inflammatory Bowel Diseases on Anti-TNF Therapy.

Inflamm Bowel Dis 2018 08;24(9):2086-2092

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.

Background: Anti-tumor necrosis factor (anti-TNF) therapies are effective treatments for inflammatory bowel diseases (IBD). However, infections, psoriasis, and eczema are potential manifestations. Descriptions of these are limited. Read More

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http://dx.doi.org/10.1093/ibd/izy112DOI Listing
August 2018
5 Reads

Low Rates of Dermatologic Care and Skin Cancer Screening Among Inflammatory Bowel Disease Patients.

Dig Dis Sci 2018 10 30;63(10):2729-2739. Epub 2018 Apr 30.

Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, M2, C-wing, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Background: Dermatologic manifestations of inflammatory bowel disease (IBD) are common, and certain IBD medications increase the risk of skin cancer.

Aims: To define the rates of care and factors associated with dermatologic utilization with a focus on skin cancer screening.

Methods: We utilized a prospective, natural history IBD research registry to evaluate all outpatient healthcare encounters from 2010 to 2016. Read More

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http://link.springer.com/10.1007/s10620-018-5056-x
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http://dx.doi.org/10.1007/s10620-018-5056-xDOI Listing
October 2018
37 Reads

Cutaneous toxicities of epidermal growth factor receptor inhibitors: A prospective study in 60 Asian patients.

Asian Pac J Allergy Immunol 2019 Mar;37(1):12-18

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Several prospective studies have been conducted in epidermal growth factor receptor (EGFR) inhibitor-related cutaneous reactions in Caucasian patients, but prospective studies in Asian populations are scarce.

Objective: To investigate the cutaneous side effects of EGFR inhibitors in Asian cancer patients and to assess tumor response to dermatologic manifestations.

Methods: Sixty patients with lung or colorectal cancer who were receiving EGFR inhibitors were prospectively followed for at least one year by oncologists and dermatologists. Read More

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http://apjai-journal.org/wp-content/uploads/2018/03/AP-14031
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http://dx.doi.org/10.12932/AP-140317-0047DOI Listing
March 2019
12 Reads
1.255 Impact Factor

Neurofibromatosis Type 1 with Massive Ventricular Polyposis: First Report in the Medical Literature.

Open Access Maced J Med Sci 2018 Jan 1;6(1):71-73. Epub 2018 Jan 1.

Medical Institute of Ministry of Interior, Department of General, Vascular and Abdominal Surgery, General Skobelev 79, 1606 Sofia, Bulgaria.

Background: Neurofibromatosis type 1 () is a multisystemic disorder with genetic background, characterised by specific cutaneous findings, skeletal dysplasias, and growth of both benign and malignant nervous system tumours. is caused by mutations in the gene, situated in chromosome 17q11.2, with an autosomal dominant pattern of inheritance and clinical manifestation of neurofibromas, malignant peripheral nerve sheath tumour, optic and non-optic nerve gliomas, congenital heart disease, cardiovascular and cerebrovascular disease and orthopaedic disorders. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2018.004
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http://dx.doi.org/10.3889/oamjms.2018.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816321PMC
January 2018
27 Reads

Clinical Characteristics and Factors Associated With Disability and Impaired Quality of Life in Children With Juvenile Systemic Sclerosis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Arthritis Care Res (Hoboken) 2018 12 8;70(12):1806-1813. Epub 2018 Nov 8.

University of Washington, Seattle.

Objective: To investigate clinical manifestations of juvenile systemic sclerosis (SSc; scleroderma), including disease characteristics and patient quality of life, using the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry.

Methods: Patients with juvenile SSc were prospectively enrolled between 2010 and 2013. The diagnosis of juvenile SSc was determined by the enrolling pediatric rheumatologist, with the requirement for disease onset prior to age 18 years. Read More

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http://dx.doi.org/10.1002/acr.23547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344352PMC
December 2018
24 Reads

Crohn disease-associated neutrophilic urticarial dermatosis: report and literature review of neutrophilic urticarial dermatosis.

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Department of Dermatology, University of California San Diego, La Jolla, California.

Neutrophilic urticarial dermatosis (NUD) is a useful diagnostic term for urticarial lesions that are less pruritic and more painful than conventional urticaria. The histopathologic features include neutrophilic infiltrates in the interstitial dermis with a higher density than idiopathic urticaria. NUD has been associated with several systemic conditions, which are predominantly autoimmune and autoinflammatory in nature. Read More

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November 2017
21 Reads

Prevalence and factors associated with gluten sensitivity in inflammatory bowel disease.

Scand J Gastroenterol 2018 Feb 7;53(2):147-151. Epub 2017 Dec 7.

a Division of Gastroenterology & Hepatology , Stanford University School of Medicine , Stanford , CA , USA.

Objectives: Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease (IBD) are unclear. This study evaluated the prevalence of GS and factors associated with GS in IBD.

Methods: Adult IBD patients at a tertiary-care medical center completed a survey of their demographics, medical history, family history, social history and symptoms. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365521.2017.1
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http://dx.doi.org/10.1080/00365521.2017.1409364DOI Listing
February 2018
48 Reads

Ocular, Auricular, and Oral Manifestations of Inflammatory Bowel Disease.

Dig Dis Sci 2017 12 24;62(12):3269-3279. Epub 2017 Oct 24.

Alpert Medical School, Brown University, Rhode Island Hospital, Providence, RI, USA.

Inflammatory bowel disease (IBD) is primarily a disease of the gastrointestinal tract, though it can often affect other organ systems. These extraintestinal manifestations occur in a quarter to one-third of patients with Crohn's disease and ulcerative colitis. While musculoskeletal and dermatologic manifestations are the most common, it is also important to be cognizant of head, eye, ear, nose, and throat (HEENT) manifestations and educate IBD patients about them. Read More

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http://dx.doi.org/10.1007/s10620-017-4781-xDOI Listing
December 2017
23 Reads

Metastatic Crohn disease: a review of dermatologic manifestations and treatment.

Cutis 2017 Jun;99(6):E33-E40

Private practice, Myrtle Beach, South Carolina, USA.

It is estimated that almost half of patients affected with Crohn disease (CD) experience a dermatologic manifestation of the condition. Metastatic CD (MCD) is a rare dermatologic entity, with as few as 100 cases reported in the literature. As such, MCD presents a clinical dilemma in diagnosis and management. Read More

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June 2017
11 Reads

Beyond the Bowel: Extraintestinal Manifestations of Inflammatory Bowel Disease.

Radiographics 2017 Jul-Aug;37(4):1135-1160. Epub 2017 May 26.

From the Department of Diagnostic Radiology (J.D.O., S.E.S., L.E.J., M.R., A.M.S.), University of Utah, 30 North 1900 East, #1A71, Salt Lake City, UT 84132; and the Department of Diagnostic Radiology, University of Wisconsin, Madison, Wis (B.P.S.).

Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated inflammation of the gastrointestinal tract. IBD includes two major disease entities: Crohn disease and ulcerative colitis. Imaging plays an important role in the diagnosis and surveillance of these complex disorders. Read More

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http://dx.doi.org/10.1148/rg.2017160121DOI Listing
November 2017
62 Reads

Paradoxical ulcerative colitis during adalimumab treatment of psoriasis resolved by switch to ustekinumab.

Br J Dermatol 2018 02 28;178(2):551-555. Epub 2017 Nov 28.

Department of Dermatology, Zurich University Hospital, Zurich, Switzerland.

Here we report the case of a patient with psoriasis who developed ulcerative colitis most likely caused by adalimumab. After cessation of adalimumab, colitis improved significantly. However, as psoriasis worsened, the patient was switched to ustekinumab, which resulted in complete cessation of colitis. Read More

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http://dx.doi.org/10.1111/bjd.15631DOI Listing
February 2018
2 Reads

Imaging of Abdominal and Pelvic Manifestations of Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplant.

AJR Am J Roentgenol 2017 Jul 2;209(1):33-45. Epub 2017 May 2.

1 Department of Radiology, University of Wisconsin School of Medicine & Public Health, 600 Highland Ave, E3/311 Clinical Science Center, Madison, WI 53792-3252.

Objective: Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant (HSCT). GVHD predominantly affects the skin, gastrointestinal system and hepatobiliary systems. Imaging findings in the gastrointestinal tract include bowel wall thickening with mucosal enhancement, mesenteric edema, and vascular engorgement. Read More

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http://dx.doi.org/10.2214/AJR.17.17866DOI Listing
July 2017
49 Reads

Behçet disease in Western Algeria.

Med Sante Trop 2017 Feb;27(1):101-104

Service de médecine interne, CHU Tidjani Damerdji Tlemcen, 13000 Algérie.

The aim of the current study was to describe the epidemiological and clinical features of Behçet disease in western Algeria. This observational retrospective study examined records for patients with Behçet disease seen in our department from 1990 to 2015. Of the 61 patients included in the study, 80. Read More

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http://dx.doi.org/10.1684/mst.2017.0656DOI Listing
February 2017
34 Reads

Simultaneous Occurrence of Varicella Zoster Virus-Induced Pancreatitis and Hepatitis in a Renal Transplant Recipient: A Case Report and Review of Literature.

Perm J 2017 10;21:16-083. Epub 2017 Mar 10.

Director of Gastroenterology, Hepatology and Interventional Endoscopy at the Fortis Hospital Mohali in Chandigarh, Mohali, Punjab, India.

Introduction: Gastrointestinal complications are common after renal transplantation, including oral lesions, esophagitis, gastritis, diarrhea, and colon carcinoma. The differential diagnosis is difficult in this scenario because multiple factors such as drugs, infections, and preexisting gastrointestinal disease come into play.

Case Presentation: We report a case of varicella zoster virus-induced pancreatitis and hepatitis in a renal transplant recipient. Read More

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http://dx.doi.org/10.7812/TPP/16-083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363894PMC
September 2017
25 Reads

Tocilizumab Promotes Regulatory T-cell Alleviation in STAT3 Gain-of-function-associated Multi-organ Autoimmune Syndrome.

Clin Ther 2017 Feb 30;39(2):444-449. Epub 2017 Jan 30.

Gastroenterology and Liver Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Purpose: Signal transducer and activator of transcription 3 is a member of a family of proteins involved in the regulation of inflammation, differentiation, proliferation, and survival of cells. Here we describe a 38-year-old male who has experienced gastrointestinal, dermatologic, pulmonary, and malignant manifestations.

Methods: Whole-exome sequencing, validated by Sanger sequencing, was performed after extensive investigations. Read More

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http://dx.doi.org/10.1016/j.clinthera.2017.01.004DOI Listing
February 2017
16 Reads

[Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis].

Hautarzt 2016 Dec;67(12):940-947

Abteilung für Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.

Background: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity.

Objectives: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC).

Materials And Methods: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department. Read More

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http://dx.doi.org/10.1007/s00105-016-3894-zDOI Listing
December 2016
21 Reads

[The skin - a mirror of internal diseases].

Vnitr Lek Fall 2016;62(7-8):575-81

Unlabelled: The knowledge of the relationship between dermatologic manifestations and disorders and internal diseases may facilitate early identification of general disease. The report aims to provide an overview of dermatologic manifestations of gastrointestinal disorders, non-specific inflammatory bowel disease and gastrointestinal stromal tumours, and skin alterations related to diabetes mellitus. The role of a dermatologist is primarily to diagnose dermatoses. Read More

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June 2017
25 Reads

Inflammatory Bowel Disease: Joint Management in Gastroenterology and Dermatology.

Actas Dermosifiliogr 2017 Apr 28;108(3):184-191. Epub 2016 Aug 28.

Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.

Inflammatory bowel disease (IBD) is a complex entity that includes Crohn disease and ulcerative colitis. It is characterized by a chronic proinflammatory state of varying intensity that often leads to considerable morbidity. In the last decade, several therapeutic targets have been identified that are susceptible to the use of biological agents, including anti-tumor necrosis factor alpha antibodies, which are associated with paradoxical psoriasiform reactions in 5% of patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00017310163027
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http://dx.doi.org/10.1016/j.ad.2016.07.007DOI Listing
April 2017
5 Reads

Crohn's disease and skin.

United European Gastroenterol J 2016 Apr 21;4(2):165-71. Epub 2015 Aug 21.

Department of Clinical and Experimental Medicine 'Magrassi-Lanzara', Gastroenterology Unit, Second University of Naples, Italy.

Crohn's disease is a chronic inflammatory bowel disease potentially involving any segment of the gastrointestinal tract. Extra-intestinal manifestations may occur in 6%-40% of patients, and disorders of the skin are among the most common. This manuscript will review skin manifestations associated to Crohn's disease, with a particular focus on lesions associated to anti-tumour necrosis factor therapy. Read More

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http://dx.doi.org/10.1177/2050640615597835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804366PMC
April 2016
12 Reads

A decade of research on Incontinence-Associated Dermatitis (IAD): Evidence, knowledge gaps and next steps.

Authors:
Dimitri Beeckman

J Tissue Viability 2017 Feb 21;26(1):47-56. Epub 2016 Feb 21.

University Centre for Nursing and Midwifery, Department of Public Health, Ghent University, Ghent, Belgium. Electronic address:

Background: Incontinence-Associated Dermatitis (IAD) is one of the clinical manifestations of Moisture- Associated Skin Damage (MASD). IAD is a common problem in aged patients with fecal and/or urinary incontinence.

Aim: Update about IAD terminology, etiology, epidemiology, observation, prevention, and treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0965206X160002
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http://dx.doi.org/10.1016/j.jtv.2016.02.004DOI Listing
February 2017
42 Reads

Treatment of idiopathic pulmonary fibrosis: a network meta-analysis.

BMC Med 2016 Feb 3;14:18. Epub 2016 Feb 3.

Department of Medicine, Division of Critical Care, McMaster University, 1200 Main St W, L8S 4L8, Hamilton, ON, Canada.

Background: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with high morbidity and mortality. Effective treatments for IPF are limited. Several recent studies have investigated novel therapeutic agents for IPF, but very few have addressed their comparative benefits and harms. Read More

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http://dx.doi.org/10.1186/s12916-016-0558-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741055PMC
February 2016
111 Reads
8 Citations
7.250 Impact Factor

Dermatologic Manifestations of Systemic Diseases.

Prim Care 2015 Dec 23;42(4):607-30. Epub 2015 Oct 23.

Internal Medicine-Pediatrics, University of Michigan Medical Hospital, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48105, USA.

Dermatologic complaints are encountered frequently by the primary care provider. Patients often are required as well as want to see their primary care provider before referral to a specialist. Therefore, primary care providers must be skilled in a variety of topics including dermatology. Read More

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http://www.oregonpa.org/resources/2012CME/Dermatologic%20Man
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http://linkinghub.elsevier.com/retrieve/pii/S009545431500072
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http://dx.doi.org/10.1016/j.pop.2015.08.003DOI Listing
December 2015
12 Reads

Spectrum of Eosinophilic End-Organ Manifestations.

Immunol Allergy Clin North Am 2015 Aug 17;35(3):403-11. Epub 2015 Jun 17.

Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

Eosinophil-associated disorders can affect practically all tissues and organs in the body, either individually or in combination. This article provides an overview of end-organ manifestations of eosinophilia and discusses selected organ systems, including the upper and lower respiratory, cardiovascular, gastrointestinal, nervous, dermatologic, and renal systems. Mechanisms by which eosinophilia leads to end-organ damage are also considered. Read More

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http://dx.doi.org/10.1016/j.iac.2015.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515759PMC
August 2015
17 Reads

Body image dissatisfaction in patients with inflammatory bowel disease.

Inflamm Bowel Dis 2015 Feb;21(2):345-52

*Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; †Department of Biostatics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; ‡Division of Gastroenterology, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island; §Department of Pediatric Gastroenterology, Rhode Island Hospital, Providence, Rhode Island; ‖Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia; ¶Crohn's & Colitis Foundation of America, New York, New York; and **Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Despite the fact that the inflammatory bowel diseases (IBD) and their treatments may affect physical appearance, the effect of IBD on body image is poorly understood. The aims of this study were to determine whether body image dissatisfaction (BID) changes over time in patients with IBD and to examine the demographic and disease-related variables associated with decreased body image.

Methods: Adults aged 18 and above in the Ocean State Crohn's and Colitis Area Registry with at least 2 years of follow-up were eligible for this study. Read More

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http://pdfs.journals.lww.com/ibdjournal/2015/02000/Body_Imag
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/MIB.0000000000000270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373552PMC
February 2015
45 Reads

Bone marrow engraftment and associated dermatologic sequelae in a three-yr-old after liver transplantation.

Pediatr Transplant 2015 Mar 17;19(2):E41-6. Epub 2014 Dec 17.

Harvard Medical School, Boston, MA, USA.

We present a case of a three-yr-old child with a history of multisystem Langerhans cell histiocytosis treated with systemic chemotherapy, who developed progressive liver failure and received an orthotopic split liver transplant while continuing on chemotherapy. One month following transplant, he developed acute graft-vs.-host disease of the skin and gastrointestinal tract. Read More

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http://dx.doi.org/10.1111/petr.12412DOI Listing
March 2015
27 Reads

Regulatory T cells as well as IL-10 are reduced in the skin of patients with dermatitis herpetiformis.

J Dermatol Sci 2015 Jan 18;77(1):54-62. Epub 2014 Nov 18.

Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Viale Michelangelo 41, 50125 Florence, Italy.

Background: Dermatitis herpetiformis (DH) and celiac disease (CD) are considered as autoimmune diseases that share a defined trigger (gluten) and a common genetic background (HLA-DQ2/DQ8). However, the pathogenesis of DH is not fully understood and no data are available about the immune regulation in such a disease.

Objective: The aim of this study was to assess if alterations in the pattern of the immune response and, in particular, impairments of regulatory T (Tregs) cells may contribute to the phenotypic differences between DH and CD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09231811140025
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http://dx.doi.org/10.1016/j.jdermsci.2014.11.003DOI Listing
January 2015
23 Reads

Skin gangrene as an extraintestinal manifestation of inflammatory bowel disease.

An Bras Dermatol 2014 Nov-Dec;89(6):967-9

Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.

Inflammatory bowel diseases can commonly present many cutaneous lesions which can contribute to the diagnosis of the disease or its activity. The most frequent cutaneous or mucocutaneous manifestations suggesting ulcerative rectocolitis activity are erythema nodosum (3-10%), pyoderma gangrenosum (5-12%) and aphthous stomatitis (4%). Other reactive skin manifestations related to immunological mechanisms associated with the inflammatory bowel disease are: Sweet's syndrome, arthritis-dermatitis syndrome associated with inflammatory bowel disease and leukocytoclastic vasculitis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230667PMC
http://dx.doi.org/10.1590/abd1806-4841.20143001DOI Listing
April 2015
8 Reads

Association between lichen sclerosus and celiac disease: a report of three pediatric cases.

Pediatr Dermatol 2014 Nov-Dec;31(6):e128-31. Epub 2014 Nov 10.

Division of Pediatrics, Stanford University, Palo Alto, California.

The prevalence of celiac disease (CD) is increasing and may be as high as 1% of the US population. The typical presentation of CD generally includes gastrointestinal symptoms, but more individuals are presenting with extraintestinal manifestations. A wide variety of dermatologic associations have been described with CD, including alopecia, dermatitis herpetiformis, and enamel hypoplasia. Read More

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http://dx.doi.org/10.1111/pde.12402DOI Listing
November 2015
30 Reads

Mucocutaneous manifestations of inflammatory bowel disease in Turkey.

J Cutan Med Surg 2014 Nov;18(6):397-404

Background: Mucocutaneous manifestations of inflammatory bowel diseases are relatively common; the mean incidence is around 10% at the time of diagnosis. However, during follow-up, an increased variety of skin lesions, granulomatous cutaneous disease, reactive skin eruptions, nutritional defiencies, and other associated conditions may develop.

Objective: The objective of this study was to evaluate the prevalence of the mucocutaneous manifestations and their association with gender, duration of disease, arthritis, location of the bowel disease, and disease activity. Read More

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http://journals.sagepub.com/doi/ 10.2310/7750.2014.13209
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http://dx.doi.org/10.2310/7750.2014.13209DOI Listing
November 2014
15 Reads

Neurofibromatosis type 1 and GIST: is there a correlation?

Anticancer Res 2014 Oct;34(10):5609-12

Tufts University School of Medicine, Boston, MA, U.S.A.

Background: Neurofibromatosis type 1 (NF1) is a hereditary cancer predisposition syndrome characterized by neurologic, dermatologic and orthopedic manifestations. There is a spectrum of tumors that affects individuals with NF1 at an increased incidence compared to the general population, such as neurofibromas, malignant peripheral nerve sheath tumors (MPNST) and gliomas. There has been a growing number of literature reporting an association between NF1 and gastrointestinal stromal tumors (GIST). Read More

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October 2014
17 Reads
2 Citations
1.872 Impact Factor

Extraintestinal manifestations of Helicobacter pylori: a concise review.

World J Gastroenterol 2014 Sep;20(34):11950-61

Frank Wong, Erin Rayner-Hartley, Michael F Byrne, Division of Gastroenterology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

Helicobacter pylori (H. pylori) infection has been clearly linked to peptic ulcer disease and some gastrointestinal malignancies. Increasing evidence demonstrates possible associations to disease states in other organ systems, known as the extraintestinal manifestations of H. Read More

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http://dx.doi.org/10.3748/wjg.v20.i34.11950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161781PMC
September 2014
39 Reads

Adverse Drug Reactions to Antiretroviral Therapy in HIV-Infected Patients at the Largest Public Hospital in Nicaragua.

J Int Assoc Provid AIDS Care 2014 Sep-Oct;13(5):466-70. Epub 2014 Jun 16.

Division of Infectious Diseases, Hospital Dr. Roberto Calderón Gutiérrez, Managua, Nicaragua.

Objective: Adverse drug reactions (ADRs) to antiretroviral therapy (ART) are an important cause of hospitalization, treatment discontinuation, and regimen changes in both developed and developing countries. This study is the first to examine and understand ADRs in HIV-infected patients in Nicaragua.

Methods: A retrospective descriptive study was conducted from May 2010 to March 2011, in a cohort of HIV-infected patients receiving ART at the largest public hospital in Managua, Nicaragua. Read More

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http://journals.sagepub.com/doi/10.1177/2325957414535978
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http://dx.doi.org/10.1177/2325957414535978DOI Listing
January 2018
47 Reads

Metastatic Crohn's disease: a review and approach to therapy.

J Am Acad Dermatol 2014 Oct 2;71(4):804-13. Epub 2014 Jun 2.

Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona.

Metastatic Crohn's disease (CD) is a rare cutaneous manifestation of CD that was first described nearly 50 years ago. Many subsequent reports have defined its most common clinical and histopathologic features. The pathogenesis underlying metastatic CD is unknown but various hypotheses exist. Read More

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http://dx.doi.org/10.1016/j.jaad.2014.04.002DOI Listing
October 2014
19 Reads

Management of common adverse events in patients treated with sorafenib: nurse and pharmacist perspective.

Semin Oncol 2014 Feb 9;41 Suppl 2:S17-28. Epub 2014 Jan 9.

Nurse Practitioner, Hospital of the University of Pennsylvania, Department of Otorhinolaryngology, Philadelphia, PA. Electronic address:

Sorafenib, a tyrosine kinase inhibitor, is indicated for the treatment of patients with unresectable hepatocellular carcinoma (HCC) and advanced renal cell carcinoma (RCC). Sorafenib is currently being evaluated in phase II and III trials in various malignancies as a single agent (locally advanced/metastatic radioactive iodine-refractory differentiated thyroid cancer [DTC]), as part of multimodality care (HCC), and in combination with chemotherapies (metastatic breast cancer). Grade 1 and 2 adverse events (AEs) that commonly occur during treatment (ie, dermatologic manifestations, diarrhea, fatigue, and hypertension) should be proactively managed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00937754140000
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http://dx.doi.org/10.1053/j.seminoncol.2014.01.002DOI Listing
February 2014
13 Reads

Gender and spondyloarthropathy-associated uveitis.

Authors:
Wendy M Smith

J Ophthalmol 2013 22;2013:928264. Epub 2013 Dec 22.

Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Spondyloarthropathies encompass a group of inflammatory diseases with arthritis and other features such as enthesitis and dermatologic and gastrointestinal involvement. Up to 37% of spondyloarthropathy patients may develop uveitis which is typically bilateral asynchronous acute anterior uveitis. Spondyloarthropathies with and without uveitis are more prevalent among males; the reasons for gender imbalance are unclear. Read More

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http://dx.doi.org/10.1155/2013/928264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881526PMC
June 2014
9 Reads

Bazex syndrome.

An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):209-11

Instituto de pesquisa e ensino medico, Rio de JaneiroRJ, Brazil.

Acrokeratosis Paraneoplastica or Bazex syndrome is a dermatologic manifestation usually associated with the diagnosis of squamous cell carcinoma of the upper aerodigestive tract. We report a case with exuberant clinical manifestations, exemplifying the typical cutaneous lesions in this rare syndrome, in a patient with squamous cell carcinoma of the esophagus. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20132488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876009PMC
May 2014
13 Reads

The association of psoriasiform rash with anti-tumor necrosis factor (anti-TNF) therapy in inflammatory bowel disease: a single academic center case series.

J Crohns Colitis 2014 Jun 21;8(6):480-8. Epub 2013 Nov 21.

Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA, United States; Inflammatory Bowel Disease Program, University of Washington Medical Center, Seattle, WA, United States.

Background & Aims: Anti-tumor necrosis factors (anti-TNF) including infliximab, adalimumab and certolizumab pegol are used to treat Crohn's disease (CD) and ulcerative colitis (UC). Paradoxically, while also indicated for the treatment of psoriasis, anti-TNF therapy has been associated with development of psoriasiform lesions in IBD patients and can compel discontinuation of therapy. We aim to investigate IBD patient, clinical characteristics, and frequency for the development of and outcomes associated with anti-TNF induced psoriasiform rash. Read More

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http://dx.doi.org/10.1016/j.crohns.2013.10.013DOI Listing
June 2014
35 Reads

Neutrophilic dermatoses and inflammatory bowel diseases.

G Ital Dermatol Venereol 2013 Apr;148(2):185-96

Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Italy.

Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs, which led to coining the term of neutrophilic dermatoses (ND) to define these conditions. Recently, ND have been included among the autoinflammatory diseases, which are forms due to mutations of genes regulating the innate immune responses. Both PG and SS are frequently associated with inflammatory bowel diseases (IBD), a group of chronic intestinal disorders which comprises ulcerative colitis and Crohn's disease and whose pathogenesis involves both the innate and adaptive immunity in genetically prone individuals. Read More

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April 2013
9 Reads