179 results match your criteria Dermatologic Manifestations of Gastrointestinal Disease


[Clinical Characteristics and Gene Mutations in 186 Cases of Kindler Syndrome].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2022 Apr;44(2):227-235

Department of Dermatology,State Key Laboratory of Complex Severe and Rare Diseases,PUMC Hospital,CAMS and PUMC, National Clinical Research Center for Dermatologic and Immunologic Diseases,Beijing 100730,China.

Objective To investigate the clinical characteristics and genetic mutations in Kindler syndrome(KS)and provide a theoretical basis for the diagnosis and treatment of KS. Methods The clinical data of one case of KS from Peking Union Medical College Hospital and 185 cases reported in literature were collected. The gene mutation types,patient clinical data,and tumor characteristics were statistically analyzed. Read More

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[Clinical and histopathological patterns of dermatosis in COVID-19 positive patients treated in the Unidad Médica de Alta Especialidad del Bajío, IMSS-T1, de León, Guanajuato].

Rev Chilena Infectol 2021 12;38(6):745-753

Sección de Micología, Hospital General "Dr. Manuel Gea González" Ciudad de México, México.

Background: COVID-19 disease, besides presenting respiratory manifestations, can affect other organs such as kidneys, gastrointestinal system, heart, and skin. So far, five clinical variants of dermatoses have been described. Few reports discuss the severity associated with the cutaneous manifestations of COVID-19 and the prognosis. Read More

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December 2021

The clinical, molecular, and therapeutic features of patients with IL10/IL10R deficiency: a systematic review.

Clin Exp Immunol 2022 Jun;208(3):281-291

Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Interleukin10 (IL10) and IL10 receptor (IL10R) deficiencies are monogenic inborn errors of immunity (IEI) causing early-onset inflammatory bowel diseases (IBD). In this report, we systematically reviewed articles that included related keywords using PubMed, Web of Science, and Scopus databases. The articles were screened for eligibility criteria before data extraction. Read More

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Neurological Manifestations and Psychiatric Disorders in the Course of Inflammatory Bowel Diseases.

J Gastrointestin Liver Dis 2022 03 19;31(1):107-118. Epub 2022 Mar 19.

Department of Digestive Tract Diseases, Faculty of Medicine, Medical University of Lodz, Poland.

Inflammatory bowel diseases (IBD) are characterized by cumbersome symptoms with varying severity. However, regardless of the intensity of disease activity the patients may experience extraintestinal manifestations which further deteriorate the patients' quality of life. According to the literature, nearly half of the patients with IBD will develop at least one extraintestinal manifestation in their lifespan. Read More

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Esophageal Bullous Pemphigoid.

Eur J Case Rep Intern Med 2022 1;9(2):003160. Epub 2022 Feb 1.

Department of Gastroenterology, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Bullous pemphigoid is a rare autoimmune dermatologic disease that usually occurs in the elderly. Mucous membrane lesions occur in about 10-35% of patients and are almost always limited to the oral mucous membrane. Esophageal involvement is very rare (4% of cases) and usually presents with chest pain, dysphagia, and odynophagia, though patients are frequently asymptomatic. Read More

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February 2022

Neurological manifestations of long-COVID syndrome: a narrative review.

Ther Adv Chronic Dis 2022 17;13:20406223221076890. Epub 2022 Feb 17.

Second Department of Neurology, School of Medicine, 'Attikon' University Hospital, National and Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece. Department of Neurology, The University of Tennessee Health Science Center, Memphis, TN, USA.

Accumulating evidence points toward a very high prevalence of prolonged neurological symptoms among coronavirus disease 2019 (COVID-19) survivors. To date, there are no solidified criteria for 'long-COVID' diagnosis. Nevertheless, 'long-COVID' is conceptualized as a multi-organ disorder with a wide spectrum of clinical manifestations that may be indicative of underlying pulmonary, cardiovascular, endocrine, hematologic, renal, gastrointestinal, dermatologic, immunological, psychiatric, or neurological disease. Read More

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February 2022

Strongyloides Stercoralis Infection in Hispanic Veterans Living in Puerto Rico: A Tropical Issue or a Global One?

P R Health Sci J 2021 12;40(4):174-179

Department of Medicine, Division of Gastroenterology, VA Caribbean Healthcare System, San Juan, PR.

Objective: Strongyloidiasis is a parasitic infection classified by the World Health Organization as a neglected tropical disease. Although predominantly asymptomatic, it can become a life-threatening disease in an immunocompromised host. Epidemiologic studies in the Western Hemisphere are scarce, but even more scarce are descriptions of the natural course of this disease. Read More

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December 2021

Cutaneous Crohn Disease without Intestinal Manifestations.

Adv Biomed Res 2021 26;10:39. Epub 2021 Nov 26.

Department of Dermatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Extraintestinal manifestations (EIMs) are common in patients with Crohn's disease (CD). Various reactive cutaneous conditions, including erythema nodosum and pyoderma gangrenosum frequently occur as a part of EIMs. However, cutaneous metastasis of CD is rarely encountered in CD patients. Read More

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November 2021

Hair and nail manifestations of COVID-19.

J Cosmet Dermatol 2022 Apr 2;21(4):1339-1346. Epub 2022 Feb 2.

Dermatology Unit, Spallanzani Hospital, Rome, Italy.

Emerging literature evidence shows that the manifestations of the coronavirus disease 2019 (COVID-19), which is the disease caused by SARS-CoV-2, encompass alterations of the pulmonary, cardiovascular, gastrointestinal, and neurological system. Moreover, hematologic and dermatologic manifestations have been documented. The aim of this review is to summarize the dermatologic manifestations of COVID-19 involving the hair and nails in a narrative way. Read More

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Clinical Profile and Immediate Outcome of Multisystem Inflammatory Syndrome in Children Associated with COVID-19: A Multicentric Study.

J Glob Infect Dis 2021 Oct-Dec;13(4):159-163. Epub 2021 Nov 26.

Department of Pediatrics, MKCG Medical College, Berhampur, Odisha, India.

Introduction: Following an asymptomatic or mildly symptomatic coronavirus disease (COVID-19), otherwise healthy children may develop serious manifestations in the form of cardiac, neurological, respiratory, gastrointestinal, and dermatologic dysfunction. Many such cases were being observed in Odisha, an eastern state of India, and have been reported from different health-care facilities. We related these unexplained serious manifestations to multisystem inflammatory syndrome associated with COVID-19 (MIS-C) and planned this study. Read More

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November 2021

COVID-19-related oral mucosa lesions among confirmed SARS-CoV-2 patients: a systematic review.

Int J Dermatol 2022 Jan 22;61(1):20-32. Epub 2021 Sep 22.

Department of Dermatology and Venereology, Koç University School of Medicine, İstanbul, Turkey.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for coronavirus disease 2019 (COVID-19), which manifests as a flu-like respiratory infection affecting multiple organ systems, including the gastrointestinal system, central nervous system, cardiovascular system, skin, and mucosa. In this review, we investigated the literature on specific manifestations of COVID-19 in the oral mucosa. An online literature search in PubMed, Scopus, Google Scholar, and Medline was conducted to retrieve relevant studies on confirmed COVID-19 patients with oral mucosa findings published between December 31, 2019, and April 07, 2021. Read More

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January 2022

Mucocutaneous Manifestations of Inflammatory Bowel Disease.

Cureus 2021 Aug 15;13(8):e17191. Epub 2021 Aug 15.

General Medicine, Corporación Para Estudios en la Salud (CES), Medellin, COL.

Inflammatory bowel disease (IBD) is a chronic and incurable disease, of unknown etiology, associated with an unregulated immune response to environmental triggers in a genetically predisposed host. IBD affects mainly the gastrointestinal (GI) tract and includes Crohn's disease (CD) and ulcerative colitis (UC). However, a large percentage of patients may present with extraintestinal manifestations, including mucocutaneous ones (which are the most common) and dermatologic findings, such as erythema nodosum, pyoderma gangrenosum, and aphthous stomatitis (which are the most frequently occurring). Read More

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Neonatal MIS-C: Managing the Cytokine Storm.

Pediatrics 2021 11 25;148(5). Epub 2021 Aug 25.

The Mission Hospital, Durgapur, India.

A term infant girl with uneventful antenatal history had an erythematous rash followed by fever from day 8. She was diagnosed with late-onset sepsis and was treated accordingly. She received immunoglobulin for persistent thrombocytopenia, after which there was transient improvement. Read More

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November 2021

A dermatologic perspective on multisystem inflammatory syndrome in children.

Clin Dermatol 2021 Mar-Apr;39(2):337-343. Epub 2020 Nov 26.

Columbia University Medical Center, Departments of Dermatology and Pediatrics, New York, New York, USA.

As of May 2020, an emerging immune-mediated syndrome primarily affecting children has been detected primarily in Europe and the United States. The incidence of this syndrome appears to mirror the initial infectious assault with a delay of several weeks. This syndrome has been termed "multisystem inflammatory syndrome in children" (MIS-C) and is observed in association with the coronavirus disease 2019. Read More

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A systematic review of dermatologic manifestations among adult patients with COVID-19 diagnosis.

Skin Health Dis 2021 Jun 19;1(2):e20. Epub 2021 Mar 19.

Department of Dermatology Wake Forest Baptist Health Winston-Salem North Carolina USA.

Background: Infection with COVID-19 is characterized by respiratory, gastrointestinal and neurologic symptoms. However, limited evidence exists of the involvement of the integumentary system among COVID-19 patients and evidence suggests that these symptoms may even be the first presenting sign.

Objective: To systematically evaluate the literature published on dermatologic signs of COVID-19 in order to educate doctors about the dermatologic signs of COVID-19 infection. Read More

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Immunotherapy-Induced Acute Tubulointerstitial Nephritis.

Cureus 2021 May 31;13(5):e15358. Epub 2021 May 31.

Nephrology, Grand Strand Medical Center, Myrtle Beach, USA.

Due to its minimal side-effect profile, immunotherapy has become a popular choice for the treatment of advanced melanoma as compared to conventional chemotherapy. The most common side effects associated with immunotherapy include gastrointestinal, pulmonary, and dermatologic manifestations. However, there have been very few documented occurrences of nephrotoxic side effects. Read More

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COVID-19 and the liver: A 2021 update.

Liver Int 2021 09 11;41(9):1988-1998. Epub 2021 Jul 11.

Division of Hepatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

In December 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China and has since resulted in a global pandemic in excess of 165 million reported infections and 3.4 million attributable deaths. COVID-19 is primarily a respiratory illness, which may be complicated by pneumonia and acute respiratory distress syndrome. Read More

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September 2021

A dermatologic perspective on multisystem inflammatory syndrome in children.

Clin Dermatol 2021 Jan-Feb;39(1):163-168. Epub 2020 Sep 23.

Departments of Dermatology and Pediatrics, Columbia University Medical Center, New York, New York, USA.

As of May 2020, an emerging immune-mediated syndrome mainly affecting children has been detected primarily in Europe and the United States. The incidence of this syndrome appears to mirror the initial infectious assault, with a delay of several weeks. This syndrome has been termed "multisystem inflammatory syndrome in children" (MIS-C) and is observed in association with the coronavirus disease 2019 (COVID-19). Read More

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Metastatic Crohn's disease: an underestimated entity.

J Dtsch Dermatol Ges 2021 07 7;19(7):973-982. Epub 2021 May 7.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Cutaneous metastatic Crohn's disease (MCD) is a rare but challenging dermatologic manifestation of Crohn's disease. It is histologically defined as the presence of non-caseating granulomas at skin sites separated from and non-contiguous to the gastrointestinal tract. Cutaneous metastatic Crohn's disease should be distinguished from the much more frequent contiguous cutaneous manifestations of Crohn's disease that present at perianal or, less common, peristomal sites with direct extension from the intestine to the adjacent skin. Read More

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Chronic Lymphocytic Leukemia in Neurofibromatosis Type 1 Patients: Case Report and Literature Review of a Rare Occurrence.

Authors:
Philip R Cohen

Cureus 2021 Apr 2;13(4):e14258. Epub 2021 Apr 2.

Dermatology, San Diego Family Dermatology, National City, USA.

Neurofibromatosis type 1 (NF1) is an autosomal dominant genodermatosis that may also occur as the result of a spontaneous mutation. The diagnosis can be established by the presence of two of the seven National Institutes of Health (NIH) diagnostic criteria; several dermatologic manifestations are NIH criteria used to establish the diagnosis: axillary and inguinal freckling, café-au-lait macules, and neurofibromas. Mucosal evaluation of the eyes may detect a fourth criteria: pigmented iris hamartomas (Lisch nodules). Read More

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Porphyria: awareness is the key to diagnosis!

Acta Clin Belg 2022 Jun 3;77(3):703-709. Epub 2021 May 3.

Department of General Internal Medicine, KU Leuven, Leuven, Belgium.

Porphyrias are disorders of the haem biosynthesis which are encountered infrequently and which often present themselves atypically as a combination of gastrointestinal, neurologic and/or dermatologic symptoms. Although they are primarily caused by enzyme defects, inheritance patterns are mostly not evident. Considering all of these characteristics, it is not surprising that there is a long delay between the onset of symptoms and the diagnosis of the disease, with as possible consequences impaired quality of life, irreversible neurologic damage and even death. Read More

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Atypical Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children: A Systematic Review.

Curr Pediatr Rev 2021 ;17(3):162-171

Department of Paediatrics, Patras Medical School, Rion 26504, Greece.

Background: In December 2019, a local outbreak of pneumonia was presented in Wuhan (China) and quickly identified to be caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The disease caused by SARS-CoV-2 was named COVID-19 and was soon declared a pandemic because of the millions of infections and thousands of deaths worldwide. Children infected with SARS-CoV-2 usually develop the asymptomatic or mild type of disease compared to adults. Read More

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December 2021

Clinical features of central nervous system involvement in patients with eosinophilic granulomatosis with polyangiitis: a retrospective cohort study in China.

Orphanet J Rare Dis 2021 03 31;16(1):152. Epub 2021 Mar 31.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, the Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China.

Background: Central nervous system (CNS) involvement is extremely rare in eosinophilic granulomatosis with polyangiitis (EGPA), but is associated with a poor prognosis in the five-factor score. This study aims to elucidate the clinical features and independently associated factors of EGPA with CNS involvement.

Results: CNS involvement was observed in 17. Read More

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Ustekinumab for the treatment of paradoxical skin reactions and cutaneous manifestations of inflammatory bowel diseases.

Dermatol Ther 2021 05 1;34(3):e14883. Epub 2021 Mar 1.

Division of Dermatology, Harbor-UCLA Medical Center, Torrance, California, USA.

Ustekinumab (STELARA), a human monoclonal antibody directed against IL-12 and IL-23, is FDA-approved to treat psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. Increasing recognition of paradoxical skin reactions induced by older biologic therapies used for inflammatory bowel diseases (IBD), such as, adalimumab and infliximab, has led to the investigation of ustekinumab for the treatment of the cutaneous and gastrointestinal manifestations of IBD. In addition, ustekinumab may show efficacy in treating paradoxical cutaneous reactions to tumor necrosis factor-alpha (TNF-α) inhibitors. Read More

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Clinical manifestations and long-term prognosis of Good syndrome: Results from a single-center cohort study from China.

Mod Rheumatol 2021 Sep 4;31(5):1019-1024. Epub 2021 Feb 4.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory, Beijing, China.

Objective: To describe clinical features and long-term prognosis in patients with Good syndrome (GS).

Methods: We retrospectively reviewed medical records of GS patients at Peking Union Medical College Hospital from January 2001 to May 2019. Data regarding clinical manifestations and treatments were collected. Read More

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September 2021

Ustekinumab for Extra-intestinal Manifestations of Inflammatory Bowel Disease: A Systematic Literature Review.

J Crohns Colitis 2021 Jul;15(7):1236-1243

Department of Gastroenterology and Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.

Background And Aims: Extra-intestinal manifestations [EIMs] are frequent in patients with inflammatory bowel diseases [IBD] and are challenging conditions to manage. Tumour necrosis factor alpha antagonists [anti-TNFα] are recognised as the primary therapeutic option. We aimed to summarise evidence on the efficacy of ustekinumab for the treatment of EIMs. Read More

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Extra-Gastric Manifestations of Infection.

J Clin Med 2020 Nov 30;9(12). Epub 2020 Nov 30.

Hepatogastroenterology Division, Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy.

() is a Gram-negative flagellated microorganism that has been extensively studied since its first isolation due to its widespread diffusion and association with numerous diseases. While the bacterium is proved to be a causative factor for a number of gastric diseases such as gastritis, gastric adenocarcinoma, and MALT-lymphoma, its role at other gastrointestinal levels and in other systems is being thoroughly studied. In this article, we reviewed the latest published clinical and laboratory studies that investigated associations of with hematologic diseases such as Vitamin B12- and iron-deficiency anemia, primary immune thrombocytopenia, and with a number of dermatologic and ophthalmic diseases. Read More

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November 2020

Cutaneous manifestations in pediatric oncology patients.

Pediatr Dermatol 2021 Jan 12;38(1):58-65. Epub 2020 Nov 12.

Dermatology Department, Şişli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.

Background/objectives: Oncology patients present with various skin manifestations related to primary disease and treatments. Although these skin toxicities are well described in adults, studies of pediatric oncology patients are limited. The objective of this study was to evaluate the cutaneous findings in pediatric oncology patients receiving chemotherapy. Read More

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January 2021