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    122 results match your criteria Dermatologic Manifestations of Gastrointestinal Disease

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    Neurofibromatosis Type 1 with Massive Ventricular Polyposis: First Report in the Medical Literature.
    Open Access Maced J Med Sci 2018 Jan 1;6(1):71-73. Epub 2018 Jan 1.
    Medical Institute of Ministry of Interior, Department of General, Vascular and Abdominal Surgery, General Skobelev 79, 1606 Sofia, Bulgaria.
    Background: Neurofibromatosis type 1 () is a multisystemic disorder with genetic background, characterised by specific cutaneous findings, skeletal dysplasias, and growth of both benign and malignant nervous system tumours. is caused by mutations in the gene, situated in chromosome 17q11.2, with an autosomal dominant pattern of inheritance and clinical manifestation of neurofibromas, malignant peripheral nerve sheath tumour, optic and non-optic nerve gliomas, congenital heart disease, cardiovascular and cerebrovascular disease and orthopaedic disorders. Read More

    Clinical characteristics and factors associated with disability and impaired quality of life in children with juvenile systemic sclerosis.
    Arthritis Care Res (Hoboken) 2018 Feb 18. Epub 2018 Feb 18.
    Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.
    Objective: To investigate clinical manifestations of juvenile systemic sclerosis (jSSc), including disease characteristics and patient quality of life, through the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry.

    Methods: Subjects with jSSc were prospectively enrolled between 2010 and 2013. Diagnosis of jSSc was determined by the enrolling pediatric rheumatologist, with disease onset required prior to age 18. Read More

    Crohn disease-associated neutrophilic urticarial dermatosis: report and literature review of neutrophilic urticarial dermatosis.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Department of Dermatology, University of California San Diego, La Jolla, California.
    Neutrophilic urticarial dermatosis (NUD) is a useful diagnostic term for urticarial lesions that are less pruritic and more painful than conventional urticaria. The histopathologic features include neutrophilic infiltrates in the interstitial dermis with a higher density than idiopathic urticaria. NUD has been associated with several systemic conditions, which are predominantly autoimmune and autoinflammatory in nature. Read More

    Ocular, Auricular, and Oral Manifestations of Inflammatory Bowel Disease.
    Dig Dis Sci 2017 12 24;62(12):3269-3279. Epub 2017 Oct 24.
    Alpert Medical School, Brown University, Rhode Island Hospital, Providence, RI, USA.
    Inflammatory bowel disease (IBD) is primarily a disease of the gastrointestinal tract, though it can often affect other organ systems. These extraintestinal manifestations occur in a quarter to one-third of patients with Crohn's disease and ulcerative colitis. While musculoskeletal and dermatologic manifestations are the most common, it is also important to be cognizant of head, eye, ear, nose, and throat (HEENT) manifestations and educate IBD patients about them. Read More

    Metastatic Crohn disease: a review of dermatologic manifestations and treatment.
    Cutis 2017 Jun;99(6):E33-E40
    Private practice, Myrtle Beach, South Carolina, USA.
    It is estimated that almost half of patients affected with Crohn disease (CD) experience a dermatologic manifestation of the condition. Metastatic CD (MCD) is a rare dermatologic entity, with as few as 100 cases reported in the literature. As such, MCD presents a clinical dilemma in diagnosis and management. Read More

    Beyond the Bowel: Extraintestinal Manifestations of Inflammatory Bowel Disease.
    Radiographics 2017 Jul-Aug;37(4):1135-1160. Epub 2017 May 26.
    From the Department of Diagnostic Radiology (J.D.O., S.E.S., L.E.J., M.R., A.M.S.), University of Utah, 30 North 1900 East, #1A71, Salt Lake City, UT 84132; and the Department of Diagnostic Radiology, University of Wisconsin, Madison, Wis (B.P.S.).
    Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated inflammation of the gastrointestinal tract. IBD includes two major disease entities: Crohn disease and ulcerative colitis. Imaging plays an important role in the diagnosis and surveillance of these complex disorders. Read More

    Imaging of Abdominal and Pelvic Manifestations of Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplant.
    AJR Am J Roentgenol 2017 Jul 2;209(1):33-45. Epub 2017 May 2.
    1 Department of Radiology, University of Wisconsin School of Medicine & Public Health, 600 Highland Ave, E3/311 Clinical Science Center, Madison, WI 53792-3252.
    Objective: Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant (HSCT). GVHD predominantly affects the skin, gastrointestinal system and hepatobiliary systems. Imaging findings in the gastrointestinal tract include bowel wall thickening with mucosal enhancement, mesenteric edema, and vascular engorgement. Read More

    Behçet disease in Western Algeria.
    Med Sante Trop 2017 Feb;27(1):101-104
    Service de médecine interne, CHU Tidjani Damerdji Tlemcen, 13000 Algérie.
    The aim of the current study was to describe the epidemiological and clinical features of Behçet disease in western Algeria. This observational retrospective study examined records for patients with Behçet disease seen in our department from 1990 to 2015. Of the 61 patients included in the study, 80. Read More

    Simultaneous Occurrence of Varicella Zoster Virus-Induced Pancreatitis and Hepatitis in a Renal Transplant Recipient: A Case Report and Review of Literature.
    Perm J 2017 10;21. Epub 2017 Mar 10.
    Director of Gastroenterology, Hepatology and Interventional Endoscopy at the Fortis Hospital Mohali in Chandigarh, Mohali, Punjab, India.
    Introduction: Gastrointestinal complications are common after renal transplantation, including oral lesions, esophagitis, gastritis, diarrhea, and colon carcinoma. The differential diagnosis is difficult in this scenario because multiple factors such as drugs, infections, and preexisting gastrointestinal disease come into play.

    Case Presentation: We report a case of varicella zoster virus-induced pancreatitis and hepatitis in a renal transplant recipient. Read More

    Tocilizumab Promotes Regulatory T-cell Alleviation in STAT3 Gain-of-function-associated Multi-organ Autoimmune Syndrome.
    Clin Ther 2017 Feb 30;39(2):444-449. Epub 2017 Jan 30.
    Gastroenterology and Liver Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Purpose: Signal transducer and activator of transcription 3 is a member of a family of proteins involved in the regulation of inflammation, differentiation, proliferation, and survival of cells. Here we describe a 38-year-old male who has experienced gastrointestinal, dermatologic, pulmonary, and malignant manifestations.

    Methods: Whole-exome sequencing, validated by Sanger sequencing, was performed after extensive investigations. Read More

    [Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis].
    Hautarzt 2016 Dec;67(12):940-947
    Abteilung für Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.
    Background: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity.

    Objectives: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC).

    Materials And Methods: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department. Read More

    [The skin - a mirror of internal diseases].
    Vnitr Lek Fall 2016;62(7-8):575-81
    Unlabelled: The knowledge of the relationship between dermatologic manifestations and disorders and internal diseases may facilitate early identification of general disease. The report aims to provide an overview of dermatologic manifestations of gastrointestinal disorders, non-specific inflammatory bowel disease and gastrointestinal stromal tumours, and skin alterations related to diabetes mellitus. The role of a dermatologist is primarily to diagnose dermatoses. Read More

    Inflammatory Bowel Disease: Joint Management in Gastroenterology and Dermatology.
    Actas Dermosifiliogr 2017 Apr 28;108(3):184-191. Epub 2016 Aug 28.
    Servicio de Dermatología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
    Inflammatory bowel disease (IBD) is a complex entity that includes Crohn disease and ulcerative colitis. It is characterized by a chronic proinflammatory state of varying intensity that often leads to considerable morbidity. In the last decade, several therapeutic targets have been identified that are susceptible to the use of biological agents, including anti-tumor necrosis factor alpha antibodies, which are associated with paradoxical psoriasiform reactions in 5% of patients. Read More

    Crohn's disease and skin.
    United European Gastroenterol J 2016 Apr 21;4(2):165-71. Epub 2015 Aug 21.
    Department of Clinical and Experimental Medicine 'Magrassi-Lanzara', Gastroenterology Unit, Second University of Naples, Italy.
    Crohn's disease is a chronic inflammatory bowel disease potentially involving any segment of the gastrointestinal tract. Extra-intestinal manifestations may occur in 6%-40% of patients, and disorders of the skin are among the most common. This manuscript will review skin manifestations associated to Crohn's disease, with a particular focus on lesions associated to anti-tumour necrosis factor therapy. Read More

    A decade of research on Incontinence-Associated Dermatitis (IAD): Evidence, knowledge gaps and next steps.
    J Tissue Viability 2017 Feb 21;26(1):47-56. Epub 2016 Feb 21.
    University Centre for Nursing and Midwifery, Department of Public Health, Ghent University, Ghent, Belgium. Electronic address:
    Background: Incontinence-Associated Dermatitis (IAD) is one of the clinical manifestations of Moisture- Associated Skin Damage (MASD). IAD is a common problem in aged patients with fecal and/or urinary incontinence.

    Aim: Update about IAD terminology, etiology, epidemiology, observation, prevention, and treatment. Read More

    Treatment of idiopathic pulmonary fibrosis: a network meta-analysis.
    BMC Med 2016 Feb 3;14:18. Epub 2016 Feb 3.
    Department of Medicine, Division of Critical Care, McMaster University, 1200 Main St W, L8S 4L8, Hamilton, ON, Canada.
    Background: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with high morbidity and mortality. Effective treatments for IPF are limited. Several recent studies have investigated novel therapeutic agents for IPF, but very few have addressed their comparative benefits and harms. Read More

    Dermatologic Manifestations of Systemic Diseases.
    Prim Care 2015 Dec 23;42(4):607-30. Epub 2015 Oct 23.
    Internal Medicine-Pediatrics, University of Michigan Medical Hospital, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48105, USA.
    Dermatologic complaints are encountered frequently by the primary care provider. Patients often are required as well as want to see their primary care provider before referral to a specialist. Therefore, primary care providers must be skilled in a variety of topics including dermatology. Read More

    Spectrum of Eosinophilic End-Organ Manifestations.
    Immunol Allergy Clin North Am 2015 Aug 17;35(3):403-11. Epub 2015 Jun 17.
    Division of Allergy and Inflammation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
    Eosinophil-associated disorders can affect practically all tissues and organs in the body, either individually or in combination. This article provides an overview of end-organ manifestations of eosinophilia and discusses selected organ systems, including the upper and lower respiratory, cardiovascular, gastrointestinal, nervous, dermatologic, and renal systems. Mechanisms by which eosinophilia leads to end-organ damage are also considered. Read More

    Body image dissatisfaction in patients with inflammatory bowel disease.
    Inflamm Bowel Dis 2015 Feb;21(2):345-52
    *Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; †Department of Biostatics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; ‡Division of Gastroenterology, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island; §Department of Pediatric Gastroenterology, Rhode Island Hospital, Providence, Rhode Island; ‖Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia; ¶Crohn's & Colitis Foundation of America, New York, New York; and **Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
    Background: Despite the fact that the inflammatory bowel diseases (IBD) and their treatments may affect physical appearance, the effect of IBD on body image is poorly understood. The aims of this study were to determine whether body image dissatisfaction (BID) changes over time in patients with IBD and to examine the demographic and disease-related variables associated with decreased body image.

    Methods: Adults aged 18 and above in the Ocean State Crohn's and Colitis Area Registry with at least 2 years of follow-up were eligible for this study. Read More

    Bone marrow engraftment and associated dermatologic sequelae in a three-yr-old after liver transplantation.
    Pediatr Transplant 2015 Mar 17;19(2):E41-6. Epub 2014 Dec 17.
    Harvard Medical School, Boston, MA, USA.
    We present a case of a three-yr-old child with a history of multisystem Langerhans cell histiocytosis treated with systemic chemotherapy, who developed progressive liver failure and received an orthotopic split liver transplant while continuing on chemotherapy. One month following transplant, he developed acute graft-vs.-host disease of the skin and gastrointestinal tract. Read More

    Regulatory T cells as well as IL-10 are reduced in the skin of patients with dermatitis herpetiformis.
    J Dermatol Sci 2015 Jan 18;77(1):54-62. Epub 2014 Nov 18.
    Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Viale Michelangelo 41, 50125 Florence, Italy.
    Background: Dermatitis herpetiformis (DH) and celiac disease (CD) are considered as autoimmune diseases that share a defined trigger (gluten) and a common genetic background (HLA-DQ2/DQ8). However, the pathogenesis of DH is not fully understood and no data are available about the immune regulation in such a disease.

    Objective: The aim of this study was to assess if alterations in the pattern of the immune response and, in particular, impairments of regulatory T (Tregs) cells may contribute to the phenotypic differences between DH and CD. Read More

    Skin gangrene as an extraintestinal manifestation of inflammatory bowel disease.
    An Bras Dermatol 2014 Nov-Dec;89(6):967-9
    Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
    Inflammatory bowel diseases can commonly present many cutaneous lesions which can contribute to the diagnosis of the disease or its activity. The most frequent cutaneous or mucocutaneous manifestations suggesting ulcerative rectocolitis activity are erythema nodosum (3-10%), pyoderma gangrenosum (5-12%) and aphthous stomatitis (4%). Other reactive skin manifestations related to immunological mechanisms associated with the inflammatory bowel disease are: Sweet's syndrome, arthritis-dermatitis syndrome associated with inflammatory bowel disease and leukocytoclastic vasculitis. Read More

    Association between lichen sclerosus and celiac disease: a report of three pediatric cases.
    Pediatr Dermatol 2014 Nov-Dec;31(6):e128-31. Epub 2014 Nov 10.
    Division of Pediatrics, Stanford University, Palo Alto, California.
    The prevalence of celiac disease (CD) is increasing and may be as high as 1% of the US population. The typical presentation of CD generally includes gastrointestinal symptoms, but more individuals are presenting with extraintestinal manifestations. A wide variety of dermatologic associations have been described with CD, including alopecia, dermatitis herpetiformis, and enamel hypoplasia. Read More

    Mucocutaneous manifestations of inflammatory bowel disease in Turkey.
    J Cutan Med Surg 2014 Nov;18(6):397-404
    Background: Mucocutaneous manifestations of inflammatory bowel diseases are relatively common; the mean incidence is around 10% at the time of diagnosis. However, during follow-up, an increased variety of skin lesions, granulomatous cutaneous disease, reactive skin eruptions, nutritional defiencies, and other associated conditions may develop.

    Objective: The objective of this study was to evaluate the prevalence of the mucocutaneous manifestations and their association with gender, duration of disease, arthritis, location of the bowel disease, and disease activity. Read More

    Neurofibromatosis type 1 and GIST: is there a correlation?
    Anticancer Res 2014 Oct;34(10):5609-12
    Tufts University School of Medicine, Boston, MA, U.S.A.
    Background: Neurofibromatosis type 1 (NF1) is a hereditary cancer predisposition syndrome characterized by neurologic, dermatologic and orthopedic manifestations. There is a spectrum of tumors that affects individuals with NF1 at an increased incidence compared to the general population, such as neurofibromas, malignant peripheral nerve sheath tumors (MPNST) and gliomas. There has been a growing number of literature reporting an association between NF1 and gastrointestinal stromal tumors (GIST). Read More

    Extraintestinal manifestations of Helicobacter pylori: a concise review.
    World J Gastroenterol 2014 Sep;20(34):11950-61
    Frank Wong, Erin Rayner-Hartley, Michael F Byrne, Division of Gastroenterology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
    Helicobacter pylori (H. pylori) infection has been clearly linked to peptic ulcer disease and some gastrointestinal malignancies. Increasing evidence demonstrates possible associations to disease states in other organ systems, known as the extraintestinal manifestations of H. Read More

    Adverse Drug Reactions to Antiretroviral Therapy in HIV-Infected Patients at the Largest Public Hospital in Nicaragua.
    J Int Assoc Provid AIDS Care 2014 Sep-Oct;13(5):466-70. Epub 2014 Jun 16.
    Division of Infectious Diseases, Hospital Dr. Roberto Calderón Gutiérrez, Managua, Nicaragua.
    Objective: Adverse drug reactions (ADRs) to antiretroviral therapy (ART) are an important cause of hospitalization, treatment discontinuation, and regimen changes in both developed and developing countries. This study is the first to examine and understand ADRs in HIV-infected patients in Nicaragua.

    Methods: A retrospective descriptive study was conducted from May 2010 to March 2011, in a cohort of HIV-infected patients receiving ART at the largest public hospital in Managua, Nicaragua. Read More

    Metastatic Crohn's disease: a review and approach to therapy.
    J Am Acad Dermatol 2014 Oct 2;71(4):804-13. Epub 2014 Jun 2.
    Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona.
    Metastatic Crohn's disease (CD) is a rare cutaneous manifestation of CD that was first described nearly 50 years ago. Many subsequent reports have defined its most common clinical and histopathologic features. The pathogenesis underlying metastatic CD is unknown but various hypotheses exist. Read More

    Management of common adverse events in patients treated with sorafenib: nurse and pharmacist perspective.
    Semin Oncol 2014 Feb 9;41 Suppl 2:S17-28. Epub 2014 Jan 9.
    Nurse Practitioner, Hospital of the University of Pennsylvania, Department of Otorhinolaryngology, Philadelphia, PA. Electronic address:
    Sorafenib, a tyrosine kinase inhibitor, is indicated for the treatment of patients with unresectable hepatocellular carcinoma (HCC) and advanced renal cell carcinoma (RCC). Sorafenib is currently being evaluated in phase II and III trials in various malignancies as a single agent (locally advanced/metastatic radioactive iodine-refractory differentiated thyroid cancer [DTC]), as part of multimodality care (HCC), and in combination with chemotherapies (metastatic breast cancer). Grade 1 and 2 adverse events (AEs) that commonly occur during treatment (ie, dermatologic manifestations, diarrhea, fatigue, and hypertension) should be proactively managed. Read More

    Gender and spondyloarthropathy-associated uveitis.
    J Ophthalmol 2013 22;2013:928264. Epub 2013 Dec 22.
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
    Spondyloarthropathies encompass a group of inflammatory diseases with arthritis and other features such as enthesitis and dermatologic and gastrointestinal involvement. Up to 37% of spondyloarthropathy patients may develop uveitis which is typically bilateral asynchronous acute anterior uveitis. Spondyloarthropathies with and without uveitis are more prevalent among males; the reasons for gender imbalance are unclear. Read More

    Bazex syndrome.
    An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):209-11
    Instituto de pesquisa e ensino medico, Rio de JaneiroRJ, Brazil.
    Acrokeratosis Paraneoplastica or Bazex syndrome is a dermatologic manifestation usually associated with the diagnosis of squamous cell carcinoma of the upper aerodigestive tract. We report a case with exuberant clinical manifestations, exemplifying the typical cutaneous lesions in this rare syndrome, in a patient with squamous cell carcinoma of the esophagus. Read More

    The association of psoriasiform rash with anti-tumor necrosis factor (anti-TNF) therapy in inflammatory bowel disease: a single academic center case series.
    J Crohns Colitis 2014 Jun 21;8(6):480-8. Epub 2013 Nov 21.
    Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA, United States; Inflammatory Bowel Disease Program, University of Washington Medical Center, Seattle, WA, United States.
    Background & Aims: Anti-tumor necrosis factors (anti-TNF) including infliximab, adalimumab and certolizumab pegol are used to treat Crohn's disease (CD) and ulcerative colitis (UC). Paradoxically, while also indicated for the treatment of psoriasis, anti-TNF therapy has been associated with development of psoriasiform lesions in IBD patients and can compel discontinuation of therapy. We aim to investigate IBD patient, clinical characteristics, and frequency for the development of and outcomes associated with anti-TNF induced psoriasiform rash. Read More

    Neutrophilic dermatoses and inflammatory bowel diseases.
    G Ital Dermatol Venereol 2013 Apr;148(2):185-96
    Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Italy.
    Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs, which led to coining the term of neutrophilic dermatoses (ND) to define these conditions. Recently, ND have been included among the autoinflammatory diseases, which are forms due to mutations of genes regulating the innate immune responses. Both PG and SS are frequently associated with inflammatory bowel diseases (IBD), a group of chronic intestinal disorders which comprises ulcerative colitis and Crohn's disease and whose pathogenesis involves both the innate and adaptive immunity in genetically prone individuals. Read More

    Psoriasis and erythema nodosum: two comorbidities of inflammatory bowel diseases.
    G Ital Dermatol Venereol 2013 Apr;148(2):175-84
    Department of Dermatology, Catholic University of the Sacred Heart, Rome, Italy.
    Extra-intestinal manifestations are a relatively common complications of Inflammatory Bowel Diseases (IBD) and skin is one of the organs most commonly affected. Cutaneous findings in IBD patients may be related to different pathogenetic mechanisms and in some cases the etiologic link has not been fully elucidated. In particular, this is the case of psoriasis and erythema nodosum, two of the most frequent skin diseases observed in IBD patients. Read More

    Skin side effects of inflammatory bowel disease therapy.
    Inflamm Bowel Dis 2013 Apr;19(5):1086-98
    Gastroenterology Service, Surgery Department, Hospital Beatriz Ângelo, Loures, Portugal.
    Skin manifestations are common in patients suffering from inflammatory bowel disease (IBD) and can be associated with the disease itself, with nutritional deficiencies, or with therapy. All drugs currently used for treating IBD have the potential to cause dermatologic manifestations that can have a wide range of clinical presentations, from mild drug eruptions to potentially life-threatening immune-mediated reactions. The wider use of thiopurines and anti-tumor necrosis factor in the past years has led to the recognition of 2 more skin complications of IBD therapy: the potentially disfiguring non-melanoma skin cancer associated with the current or past use of thiopurines and the paradoxical new onset or exacerbation of anti-tumor necrosis factor-associated psoriasis. Read More

    Behçet's disease in India: a dermatological perspective.
    Indian J Dermatol Venereol Leprol 2013 Mar-Apr;79(2):199-204
    Department of Dermatology and STD, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India.
    Background: Behcet's disease (BD) is a chronic, recurrent, multi-system inflammatory disorder involving mucocutaneous (MC), ocular, intestinal, articular, vascular, urogenital and neurologic systems. BD occurs with a high prevalence in the Mediterranean population. There is scarcity of clinical data on BD from India with only three case series in the last two decades. Read More

    The skin: a mirror to the gut.
    Int J Colorectal Dis 2013 Jul 18;28(7):889-913. Epub 2013 Jan 18.
    Division of Gastroenterology, Elmhurst Hospital Center, Mount Sinai School of Medicine, 79-01 Broadway, Elmhurst, NY 11373, USA.
    Introduction: This review discusses the diseases with involvement of both skin and gut. GI manifestations of vesicobullous disorders and systemic diseases and syndromes involving skin and gut, dermatologic manifestations of inflammatory bowel disease (IBD), polyposis syndromes, and GI malignancies have been discussed. Diagnostic and treatment approaches towards these disorders are summarized. Read More

    Cutaneous manifestations of gastrointestinal disease: part II.
    J Am Acad Dermatol 2013 Feb;68(2):211.e1-33; quiz 244-6
    Division of Dermatology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA.
    The gastrointestinal (GI) and cutaneous organ systems are closely linked. In part I of this continuing medical education article, the intricacies of this relationship were explored as they pertained to hereditary polyposis disorders, hamartomatous disorders, and paraneoplastic disease. Part II focuses on the cutaneous system's links to inflammatory bowel disease and vascular disorders. Read More

    Cutaneous manifestations of gastrointestinal disease: part I.
    J Am Acad Dermatol 2013 Feb;68(2):189.e1-21; quiz 210
    Division of Dermatology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA.
    Cutaneous findings are not uncommonly a concomitant finding in patients afflicted with gastrointestinal (GI) diseases. The dermatologic manifestations may precede clinically evident GI disease. Part I of this 2-part CME review focuses on dermatologic findings as they relate to hereditary and nonhereditary polyposis disorders and paraneoplastic disorders. Read More

    Ultrasonographic assessment of the thyroid gland structure in inflammatory bowel disease patients.
    Adv Clin Exp Med 2012 Jan-Feb;21(1):43-6
    Department of Gastroenterology and Hepatology, Wroclaw Medical University, Poland.
    Background: The etiopathogenesis of inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is still not fully elucidated and seems to be multifactorial. It has been suggested that genetic, immunological and environmental factors participate in IBD development. IBD extraintestinal manifestations include rheumatic, metabolic, dermatologic, ophthalmologic, hepatobiliary, pancreatic, urologic, pulmonary, neurological, hematological and thromboembolic complications. Read More

    Symptoms and esophageal motility based on phenotypic findings of scleroderma.
    Dis Esophagus 2013 Feb-Mar;26(2):197-203. Epub 2012 May 16.
    Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
    Scleroderma esophagus is characterized by ineffective peristalsis and reduced esophageal sphincter pressure. Esophageal disease in scleroderma can precede cutaneous manifestations and has been associated with Raynaud's phenomenon (RP) and pulmonary fibrosis (PF). The objective of the study is to evaluate the impact of cutaneous findings, RP, and PF on demographics, symptoms, and esophageal motility in patients with scleroderma. Read More

    Pediatric scleroderma: systemic or localized forms.
    Pediatr Clin North Am 2012 Apr 6;59(2):381-405. Epub 2012 Apr 6.
    Division of Rheumatology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
    Pediatric scleroderma includes 2 major groups of clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). Although both share a common pathophysiology, their clinical manifestations differ. LS is typically confined to the skin and underlying subcutis, with up to a quarter of patients showing extracutaneous disease manifestations such as arthritis and uveitis. Read More

    Dermatologic manifestations in inflammatory bowel disease in Tunisia.
    Tunis Med 2012 Mar;90(3):252-7
    Dermatology, La Rabta Hospital,Tunis.
    Background: Cutaneous manifestations are the most common extra intestinal manifestations associated with inflammatory bowel disease (IBD).

    Aim: To assess the epidemio-clinical profile of skin manifestations in IBD.

    Methods: A prospective and descriptive study was conducted. Read More

    [Early diagnosis of Fabry disease in children].
    Minerva Pediatr 2011 Oct;63(5):425-30
    Dipartimento di Scienze Mediche, Università del Piemonte Orientale, Novara, Italia.
    Fabry disease, a rare X-linked lysosomal storage disorder, is caused by deficiency of the enzyme α-galactosidase A. The incidence, ranging from one over 40 000 to one over 11 7000 worldwide is probably underestimated due to its unspecific pattern of presentation. The symptoms, including neurological, gastrointestinal, renal, ophthalmological and dermatologic manifestations, start in childhood and adolescence, cause a significant morbidity and are likely to affect the patient's quality of life. Read More

    Clinicopathologic features and treatment outcomes in Cronkhite-Canada syndrome: support for autoimmunity.
    Dig Dis Sci 2012 Feb 1;57(2):496-502. Epub 2011 Sep 1.
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
    Background And Aims: Cronkhite-Canada syndrome (CCS) is a noninherited condition, associated with high morbidity, and characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, and diarrhea. All features may respond to immunosuppressive therapy, but little is known about the etiology. An autoimmune origin has been suggested but not proved. Read More

    Skin signs of systemic diseases.
    Clin Dermatol 2011 Sep-Oct;29(5):531-40
    Department of Dermatology, University of Athens, Andreas Sygros Hospital, 5th Ionos Dragoumi St, 16121 Athens, Greece.
    The skin should not be considered as an isolated organ but rather as a definite functioning system that communicates with the internal environment. Skin signs of systemic diseases occur frequently and sometimes feature the first symptoms of an internal disease; furthermore, these manifestations may be the sole expressions of otherwise asymptomatic systemic disorders. A number of dermatologic signs, symptoms, and disorders can be invaluable as markers of systemic disease. Read More

    [Phrynoderma secondary to vitamin A deficiency in a patient with biliopancreatic diversion].
    Nutr Hosp 2011 Mar-Apr;26(2):421-4
    Unidad de Nutrición Clínica y Dietética, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
    Biliopancreatic diversion (BPD) is a malabsorptivebariatric procedure can lead to the development of several nutritional complications, including fat-soluble vitamins deficiencies. Routine supplementation with vitamins and trace elements and a close follow-up long-term can prevent these nutritional risks. Vitamin A participates in ocular metabolism, epithelial differentiation, growth, and embryogenesis. Read More

    Leucocytoclastic vasculitis in severe ulcerative colitis.
    Mil Med 2011 May;176(5):581-3
    Department of Internal Medicine, 48 MDOS/SGOMI, Unit 5210 Box 320, RAF Lakenheath, Brandon, Suffolk IP27 9PN, United Kingdom.
    Ulcerative colitis may be associated with a number of extraintestinal skin manifestations including erythema nodosum and pyoderma gangrenosum. We describe an unusual case of a 26-year-old military pilot with ulcerative colitis and skin lesions diagnosed as leucocytoclastic vasculitis. The skin lesions occurred twice during the severe flare. Read More

    Pulmonary manifestations of inflammatory bowel disease: case presentations and review.
    J Crohns Colitis 2010 Oct;4(4):390-7
    Department of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
    Inflammatory bowel disease (IBD) is associated with a number of extraintestinal manifestations that may involve most organ systems. Extraintestinal manifestations are more common in Crohn disease (CD) and may include rheumatologic, ocular, dermatologic, biliary and pulmonary manifestations. The most common pulmonary manifestations of IBD are drug-induced lung disease. Read More

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