2,345 results match your criteria Dermatologic Clinics[Journal]


Hot Topics in Dermatology.

Dermatol Clin 2019 Jan;37(1):ix

Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.det.2018.09.001DOI Listing
January 2019
3 Reads

Going Viral 2019: Zika, Chikungunya, and Dengue.

Dermatol Clin 2019 Jan;37(1):95-105

Department of Dermatology, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Mitras Centro, Avenida Gonzalitos y Madero S/N, Monterrey 64460, Mexico.

Chikungunya and Zika virus infections are emerging diseases in the Americas, and dengue continues to be the most prevalent arthropod-borne virus in the world. These arbovirus diseases may spread by endemic transmission or as travel-related infections and have rapidly expanded their geographic distribution secondary to vector spread. All 3 share a similar clinical picture that includes a maculopapular rash. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.008DOI Listing
January 2019
20 Reads

Skin Cancer and Immunosuppression.

Dermatol Clin 2019 Jan 1;37(1):83-94. Epub 2018 Nov 1.

Department of Dermatology, The University of Oklahoma Health Sciences Center, 619 Northeast 13th Street, Oklahoma City, OK 73104, USA.

Immunosuppressed patients are at significantly increased risk of developing cutaneous malignancies. These malignancies are often more aggressive compared with the general population and require multidisciplinary care. This article highlights the incidence and risk factors of cutaneous malignancies in this cohort. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.009DOI Listing
January 2019
1 Read

Updates in Melanoma.

Dermatol Clin 2019 Jan;37(1):73-82

Department of Dermatology, Dermatology and Plastic Surgery Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A61, Cleveland, OH 44195, USA. Electronic address:

Skin cancer is reaching epidemic levels in the United States. Recent advances in the understanding of the pathophysiology of melanoma have allowed improved risk stratification in the revised American Joint Committee on Cancer (AJCC) criteria, new tests to capture patients at higher risk than their stage may indicate, and new treatments to offer hope and cures to patients with advanced disease. Read More

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http://dx.doi.org/10.1016/j.det.2018.08.003DOI Listing
January 2019
5 Reads

Comorbidities in Dermatology: What's Real and What's Not.

Dermatol Clin 2019 Jan 1;37(1):65-71. Epub 2018 Nov 1.

Department of Dermatology, George Washington Medical Faculty Associates, 2150 Pennsylvania Avenue Northwest, Suite 2B-427, Washington, DC 20037, USA; Department of Dermatology, George Washington School of Medicine and Health Sciences, 2150 Pennsylvania Avenue Northwest, Suite 2B-427, Washington, DC 20037, USA. Electronic address:

Comorbidities affecting dermatologic patients are of significant importance to providers and highly relevant for appropriate patient counseling, screening practices, prevention, and treatment. This article seeks to highlight several of the newest findings in the literature regarding comorbidities associated with dermatologic diseases including atopic dermatitis, hidradenitis suppurativa, alopecia areata, chronic urticaria, and the pemphigus family of immunobullous diseases. Further investigation is needed for associations between atopic dermatitis and pancreatic cancer and pemphigus family diseases and chronic obstructive pulmonary disease in order to better characterize the strength of these associations and clinical relevance. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.007DOI Listing
January 2019
4 Reads

Advances in Inflammatory Granulomatous Skin Diseases.

Dermatol Clin 2019 Jan;37(1):49-64

Dermatology Administration, Perelman Center for Advanced Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, 7th Floor, South Tower, Philadelphia, PA 19104, USA. Electronic address:

Inflammatory granulomatous dermatitides include cutaneous sarcoidosis, necrobiosis lipoidica, granuloma annulare, and reactive granulomatous dermatitis. The etiopathogenesis of these disorders is not well understood; but the T helper 1 response mediated by interferon-gamma, tumor necrosis factor-alpha, and interleukin (IL) 1, 2, and 6 and the T helper 17 response mediated by IL-17 play a role. These inflammatory granulomatous disorders often have cutaneous manifestations in addition to extracutaneous manifestations or associations with systemic diseases. Read More

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http://dx.doi.org/10.1016/j.det.2018.08.001DOI Listing
January 2019
11 Reads

Connective Tissue Disease: Current Concepts.

Dermatol Clin 2019 Jan 1;37(1):37-48. Epub 2018 Nov 1.

Departments of Dermatology and Pathology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue A61, Cleveland, OH 44195, USA. Electronic address:

Connective tissue diseases often prominently affect the skin, requiring dermatologists to play an important role in diagnosis and treatment of these patients. Herein we describe updates on the pathogenesis, clinical features, and treatment of 4 major connective tissue diseases: dermatomyositis, cutaneous lupus erythematosus, limited scleroderma (morphea), and cutaneous vasculitis. Many of these updates promise to improve clinical care of patients who suffer from dermatologic involvement of these diseases and are the result of research performed by dermatologists who have expertise in these conditions. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.006DOI Listing
January 2019
2 Reads

Biologics and Psoriasis: The Beat Goes On.

Dermatol Clin 2019 Jan 1;37(1):29-36. Epub 2018 Nov 1.

Department of Dermatology, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, 5th Floor, PO Box 1048, New York, NY 10029, USA. Electronic address:

Psoriasis is a chronic, immune-mediated, inflammatory skin disease that requires long-term therapy for disease control. This article reviews data presented in clinical trials to evaluate and compare various characteristics of biologics that are currently approved for the treatment of psoriasis. Attributes of biological agents that are examined in this article include efficacy, long-term maintenance, overall safety, median time to onset of efficacy, adjustment for body weight, frequency of injections, indication for psoriatic arthritis, and safety in pregnancy. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.004DOI Listing
January 2019
10 Reads

Contact Dermatitis: Emerging Trends.

Dermatol Clin 2019 Jan 1;37(1):21-28. Epub 2018 Nov 1.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 East 38th Street, Floor 11, New York, NY 10016, USA.

The field of contact dermatitis is constantly evolving. Trends in irritant and allergic contact dermatitis are shaped by the introduction of new chemicals, revival of older allergens, industrial practices, and consumer behaviors. This article discusses the most noteworthy trends within the field, organized by allergen category, with particular attention to newer and/or controversial allergens. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.005DOI Listing
January 2019
3 Reads

What's New in Cosmetic Dermatology.

Dermatol Clin 2019 Jan;37(1):117-128

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Dermatologic SurgiCenter, 1200 Locust Street, Philadelphia, PA 19107, USA. Electronic address:

Topical silicone gel is more beneficial than petrolatum-based products as an all-purpose wound dressing for granulating and sutured wounds, regardless of cause. Vaginal laser rejuvenation is effective in relieving genitourinary syndrome of menopause, stress urinary incontinence, vaginal relaxation syndrome, and related vulvar disorders. New cosmetic indications in the upper face for onabotulinumtoxinA have been approved by the Food and Drug Administration, whereas off-label treatments in the lower face increase in popularity. Read More

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http://dx.doi.org/10.1016/j.det.2018.08.002DOI Listing
January 2019
7 Reads

Atopic Dermatitis: New Developments.

Dermatol Clin 2019 Jan 1;37(1):11-20. Epub 2018 Nov 1.

Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, 8010 Frost Street, Suite 602, San Diego, CA 92123, USA; Department of Dermatology, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

Herein we review recent developments in our understanding and treatment of atopic dermatitis. Key insights from the recent literature are summarized, from findings on the pathogenesis of this multifactorial disease to a new and more nuanced understanding of its natural history. Therapeutic advances and new data on comorbidities are also discussed. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.003DOI Listing
January 2019
1 Read

Cosmeceuticals: What's Real, What's Not.

Dermatol Clin 2019 Jan 1;37(1):107-115. Epub 2018 Nov 1.

Dermatology Consulting Services, PLLC, 2444 North Main Street, High Point, NC 27262, USA. Electronic address:

Cosmeceuticals are cosmetics that promise to deliver physiologically relevant benefits without the incorporation of prescription drugs. To entice consumers to purchase these premium priced products, a story must be told of how the cosmeceutical delivers on these appearance improvement promises. The backbone of any cosmeceutical skin care regimen is facial cleansing and moisturizing. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.001DOI Listing
January 2019
8 Reads

New Concepts, Concerns, and Creations in Acne.

Dermatol Clin 2019 Jan 1;37(1):1-9. Epub 2018 Nov 1.

The Acne Treatment and Research Center of the DermGroup, 310 Madison Avenue, Morristown, NJ 07960, USA; Rutgers Robert Wood Johnson Medical Center, Piscataway, NJ 08820, USA. Electronic address:

Laboratory monitoring for patients on isotretinoin should include creatinine kinase in athletic males and the more liver-specific gamma glutamyltransferase. There is mounting evidence that acne pathophysiology includes a barrier defect and subsequent microbiome disruption. Avoidance of acne scars with early and aggressive treatment is a more efficient and cost-effective option than subsequent treatment. Read More

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http://dx.doi.org/10.1016/j.det.2018.07.002DOI Listing
January 2019
23 Reads

The Expanding Use of Dermatoscopy.

Dermatol Clin 2018 Oct 31;36(4):xv. Epub 2018 Jul 31.

Dermatology Clinic, University of Catania, Via Santa Sofia, 78, Catania 95123, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183109
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http://dx.doi.org/10.1016/j.det.2018.06.001DOI Listing
October 2018
4 Reads

Dermatoscopy and Reflectance Confocal Microscopy Correlations in Nonmelanocytic Disorders.

Dermatol Clin 2018 Oct 16;36(4):487-501. Epub 2018 Aug 16.

Dermatology Clinic, University of Catania, Via Santa Sofia 78, Catania 95123, Italy.

Dermatoscopy and in vivo reflectance confocal microscopy are noninvasive techniques that provide a horizontal approach, with an en face view of the skin structures. Both techniques assist in the clinical diagnosis of a variety of inflammatory and infectious cutaneous disorders. In many cases, they have shown concordance. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.015DOI Listing
October 2018
15 Reads

Dermoscopy of Pigmentary Disorders in Brown Skin.

Dermatol Clin 2018 Oct;36(4):473-485

Department of Dermatology, Command Hospital, 17/1E, Alipore Road, Alipore Police Line, Alipore, Kolkata, West Bengal 700027, India. Electronic address:

Dermoscopy is a noninvasive technique for the diagnosis, prognosis, and monitoring of pigmentary disorders in brown skin. It can be used for the diagnosis of various facial melanoses, which can avoid the need for biopsy in many cases. It can also help in early identification of the adverse effect of topical steroids and hydroquinone when they are used for the treatment of these disorders. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.014DOI Listing
October 2018
14 Reads
1.434 Impact Factor

Dermatoscopy of Common Lesions in Pediatric Dermatology.

Dermatol Clin 2018 Oct 16;36(4):463-472. Epub 2018 Aug 16.

Dermatology Clinic, University of Catania, Via S. Sofia 78, Catania 95123, Italy.

The use of dermatoscopy to assist in the diagnosis of a variety of proliferative, pigmentary, inflammatory, infectious, congenital, and genetic cutaneous and skin appendage disorders is constantly increasing, as it is effective, affordable, noninvasive, and quick to perform. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.012DOI Listing
October 2018
16 Reads
1.434 Impact Factor

Dermoscopy of Inflammatory Genital Diseases: Practical Insights.

Dermatol Clin 2018 Oct;36(4):451-461

Department of Medical Sciences, Section of Dermatology and Infectious Diseases, University of Ferrara, Via L. Ariosto 35, Ferrara 44121, Italy.

Diagnosis of genital inflammatory disorders may be difficult for several reasons, such as their similar appearance, possible misdiagnosis with infectious and malignant conditions, and peculiar anatomic conditions that may lead to modification of clinical features. Dermoscopy could be included as a part of the clinical inspection of genital diseases to support diagnosis, as well as to ideally avoid unnecessary invasive investigation. Practical guidance for the use of dermoscopy in the assessment of the main inflammatory genital diseases is provided, namely for lichen sclerosus, lichen planus, psoriasis, lichen simplex chronicus, and plasma cell mucositis. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.013DOI Listing
October 2018
20 Reads

Dermoscopy for the Diagnosis of Conjunctival Lesions.

Dermatol Clin 2018 Oct 16;36(4):439-449. Epub 2018 Aug 16.

Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria Alle Scotte Hospital, Viale Bracci 16, Siena 53100, Italy.

This article describes the present literature on dermoscopy of conjunctiva and shows the results of a dermoscopy study of 147 conjunctival tumors. Melanomas were characterized by a heavy pigmentation, irregular dots, and a higher prevalence of gray color compared with nevi. Squamous cell carcinomas had peculiar hairpin and glomerular vessels. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.011DOI Listing
October 2018
23 Reads

Onychoscopy: Dermoscopy of the Nails.

Dermatol Clin 2018 Oct;36(4):431-438

Department of Specialised Experimental and Diagnostic Medicine, Dermatology, Alma Mater Studiorum, Università di Bologna, Bologna, Italy.

Onychoscopy is the examination of the nail unit using a dermoscope. The dermoscopic criteria for a valid diagnosis have been developed and assessed in numerous papers. However, in all nail alterations that are suspicious or potentially malignant, a surgical intervention with subsequent histopathological evaluation should be performed. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.010DOI Listing
October 2018
6 Reads

Trichoscopy in Hair Shaft Disorders.

Dermatol Clin 2018 Oct 16;36(4):421-430. Epub 2018 Aug 16.

Department of Dermatology, Medical University of Warsaw, Pawinskiego 5, 02-106, Warszawa, Poland.

Trichoscopy allows analyzing the structure and size of growing hair shafts in their natural environment in children and adults. The method replaces light microscopy, which requires pulling of multiple hairs for investigation. In monilethrix, trichoscopy shows uniform elliptical nodosities with intermittent constrictions. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.009DOI Listing
October 2018
22 Reads

Trichoscopy Tips.

Dermatol Clin 2018 Oct 14;36(4):413-420. Epub 2018 Aug 14.

Department of Dermatology and Cutaneous Surgery, Miami Miller School of Medicine, University of Miami, 1295 NW 14th Street South Building Suites K-M, Miami, FL 33125, USA.

Although trichoscopy has only recently been introduced in the assessment of hair and scalp disorders, it is already considered an essential diagnostic tool by many experts in the field. This article discusses topics that are often a source of doubt among clinicians, and tips that may help dermatologists better perform trichoscopy. Subjects include fundamental concepts needed to start performing the method, basic trichoscopic structures, tips to identify a scarring condition and to approach a patient with a receding hairline, features that are unique to children, those that are typically seen in the dark scalp, and pitfalls of the technique. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.008DOI Listing
October 2018
1 Read

Dermoscopy of Adnexal Tumors.

Dermatol Clin 2018 Oct 16;36(4):397-412. Epub 2018 Aug 16.

Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, C/Maestro Alonso 109, 03010 Alicante, Spain.

Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.007DOI Listing
October 2018
13 Reads

Dermatoscopy of Vascular Lesions.

Dermatol Clin 2018 Oct 31;36(4):389-395. Epub 2018 Jul 31.

Dermatology Unit, University of Campania Luigi Vanvitelli, Via Pansini 5, Naples 80131, Italy.

Cutaneous vascular lesions (VLs) represent a very common reason for dermatologic consultation for patients. In most cases, VLs are benign and self-limiting. However, because they often mimic malignant skin tumors, their correct and prompt identification is very important in daily practice. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.006DOI Listing
October 2018
11 Reads

Dermoscopy of Lymphomas and Pseudolymphomas.

Dermatol Clin 2018 Oct 14;36(4):377-388. Epub 2018 Aug 14.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Viale Risorgimento 80, Reggio Emilia 42123, Italy; Dermatology Department, University of Modena and Reggio Emilia, via del Pozzo 71, Modena 41124, Italy.

Primary cutaneous lymphomas are a heterogeneous group that includes 2 main groups of primary T- and B-cell lymphomas, which can involve the skin with distinct variability in clinical presentation, histopathology, immunophenotypes, molecular signature, and prognosis. The authors describe the most frequent clinical forms of cutaneous lymphomas and their dermoscopic features. Even if the diagnosis of these entities is still based on a cellular level and the literature on dermoscopy in cutaneous lymphomas is limited and, for several entities it is based only on single case reports/case series, we think that know how they appear also in dermoscopy can be useful for helping in the clinical diagnosis. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.005DOI Listing
October 2018
16 Reads

Dermatoscopy of Granulomatous Disorders.

Dermatol Clin 2018 Oct 2;36(4):369-375. Epub 2018 Aug 2.

Department of Medical Area, Institute of Dermatology, University of Udine, Udine, Italy.

Although diagnosis of cutaneous granulomatous disorders (CGDs) is usually suspected based on morphologic findings, localization, and anamnestic data, clinical differentiation from each other and from similar dermatoses may be challenging. Recently, dermatoscopy has been demonstrated to be a useful tool for assisting the recognition of several CGDs. This article provides a current overview of the dermatoscopic features of the main noninfectious and infectious CGDs, including sarcoidosis, necrobiosis lipoidica, granuloma annulare, rheumatoid nodules, and leishmaniasis. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.004DOI Listing
October 2018
9 Reads

Dermoscopy of Common Inflammatory Disorders.

Dermatol Clin 2018 Oct 31;36(4):359-368. Epub 2018 Jul 31.

1st Department of Dermatology - Venereology, State Clinic of Dermatology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, 124 Delfon Street, Thessaloniki 54643, Greece. Electronic address:

In addition to its "traditional" application for the early diagnosis of melanoma and nonmelanoma skin cancers, dermoscopy gains appreciation in fields beyond dermato-oncology. Nowadays, dermoscopy has been established as a reliable adjunctive tool to the everyday clinical practice of general dermatology. Morphology and distribution of vascular structures, background colors, follicular abnormalities, and the presence of scales are important features that should be evaluated. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.003DOI Listing
October 2018
14 Reads

Dermatoscopy of Parasitic and Infectious Disorders.

Dermatol Clin 2018 Oct 17;36(4):349-358. Epub 2018 Aug 17.

Dermatology Clinic, University of Catania, Via Santa Sofia 78, Catania 95123, Italy. Electronic address:

The use of dermatoscopy in the diagnosis and management of parasitic and infectious skin disorders has been defined as entodermoscopy, and several studies have confirmed its advantages in dermatology. Dermatoscopic patterns of several parasitic, viral, and fungal skin infections have been identified and herein described. A noninvasive, fast, and accurate diagnosis plays an important role in containing the spread of contagious skin disorders. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.002DOI Listing
October 2018
15 Reads

Dermatoscopy: Instrumental Update.

Dermatol Clin 2018 Oct 16;36(4):345-348. Epub 2018 Aug 16.

Dermatology Clinic, University of Catania, Via S. Sofia 78, Catania 95123, Italy.

Dermatoscopy is a noninvasive technique that allows in vivo, magnified observation of skin details and structures not visible to the naked eye. It may be performed using handheld devices or computer-assisted digital systems or videodermatoscopes. The handheld dermatoscope is the most used device because it is user-friendly and relatively inexpensive. Read More

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http://dx.doi.org/10.1016/j.det.2018.05.001DOI Listing
October 2018
2 Reads

Chronic Itch: A Disease in Its Own Right.

Authors:
Gil Yosipovitch

Dermatol Clin 2018 Jul 20;36(3):xv-xvi. Epub 2018 Mar 20.

Department of Dermatology and Cutaneous Surgery, and Miami Itch Center, Miller School of Medicine, University of Miami, 1475 Northwest 12th Avenue, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.det.2018.02.017DOI Listing
July 2018
1 Read

Erratum.

Authors:

Dermatol Clin 2018 Jul;36(3):xiii

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http://dx.doi.org/10.1016/j.det.2018.02.018DOI Listing
July 2018
2 Reads

Drugs on the Horizon for Chronic Pruritus.

Dermatol Clin 2018 Jul 26;36(3):335-344. Epub 2018 Apr 26.

Kaplan-Amonette Department of Dermatology, University of Tennessee Health Science Center, 930 Madison Avenue, Suite 840, Memphis, TN 38163, USA. Electronic address:

Chronic pruritus is a common condition that has a detrimental impact on quality of life. As the molecular pathogenesis of itch is elucidated, novel therapies that disrupt itch pathways are being investigated. Emerging treatments include drugs targeting the neural system, drugs targeting the immune system, antihistamines, bile acid transport inhibitors, and topical drugs that work through a variety of mechanisms such as phosphodiesterase-4 inhibition or targeting of nerve ion channels. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.016DOI Listing
July 2018
10 Reads

Immunomodulating Agents as Antipruritics.

Dermatol Clin 2018 Jul 16;36(3):325-334. Epub 2018 Apr 16.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Campus Box 8123, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA; Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA; Center for the Study of Itch, Washington University School of Medicine, St Louis, MO, USA. Electronic address:

Chronic pruritus, or itch lasting greater than 6 weeks, is an increasingly common and debilitating medical problem. Recent studies have unveiled previously unrecognized neuroimmune axes whereby inflammatory cytokines act directly on the nervous system to promote itch. Thus, the emergence of newer targeted biologic therapies has generated the possibility of novel treatment strategies for chronic itch disorders. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.014DOI Listing
July 2018
5 Reads

Pruritus Associated with Targeted Anticancer Therapies and Their Management.

Dermatol Clin 2018 Jul;36(3):315-324

Oncodermatology Program, Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Outpatient Center, 16 East 60th Street, Suite 407, Room 4312, New York, NY 10022, USA; Department of Medicine, Weill Cornell Medical College, 1320 York Avenue, New York, NY 10021, USA. Electronic address:

Targeted anticancer therapies have significantly increased the survival of patients with a variety of malignancies, improving tolerability and treatment duration. The increased lifespan and the expanded use of targeted agents have led to a variety of treatment-related adverse events. Pruritus, a common dermatologic adverse event with various incidences ranging from 2. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020829PMC
July 2018
11 Reads

Psychogenic Pruritus and Its Management.

Dermatol Clin 2018 Jul;36(3):309-314

Dermatology, Dell Medical School, The University of Texas at Austin, 601 East 15th Street, CEC C2.470, Austin, TX 78701, USA. Electronic address:

Chronic itching can be frustrating for patients and providers, and patients are not always willing to accept that their psychiatric health has an impact on their skin. Psychogenic pruritus is defined as itch not related to dermatologic or systemic causes. When a patient presents with pruritus, regardless of the presumed cause, the standard work-up should include a thorough history, dermatologic examination, and laboratory examinations or biopsies as needed. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.015DOI Listing
July 2018
1 Read

Scabies Itch.

Dermatol Clin 2018 Jul 1;36(3):301-308. Epub 2018 May 1.

Dermatology Department, AP-HP, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France; EpiDermE, Epidé miologie en Dermatologie et Evaluation des Thé rapeutiques, Université Paris-Est Créteil, EA 7379, 9400 Créteil, France.

Itch is the cardinal symptom of scabies, present in more than 90% of the cases, generalized and intense, worsening at night, and often sparing the head. The primary complications of the itch in scabies are secondary bacterial infections and psychosocial issues leading to impairment on life quality. Currently, there are no specific data analyzing mechanisms of the itch in scabies, but the latest progress made in the understanding of host-mite interactions may help to improve understanding. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.009DOI Listing
July 2018
7 Reads

Management of Chronic Hepatic Itch.

Dermatol Clin 2018 Jul 1;36(3):293-300. Epub 2018 May 1.

Department of Medicine 1, Friedrich-Alexander-University Erlangen-Nürnberg, Ulmenweg 18, Erlangen 91054, Germany. Electronic address:

Hepatic itch remains among the most agonizing symptoms for affected patients and a major clinical challenge for physicians. Pruritus may occur in almost all liver diseases, particularly those with cholestatic features. Hepatic itch arises irrespective of the severity of the underlying liver disease or extent of cholestasis. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.008DOI Listing
July 2018
18 Reads

End-Stage Renal Disease Chronic Itch and Its Management.

Dermatol Clin 2018 Jul 26;36(3):277-292. Epub 2018 Apr 26.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego Street 1, Wrocław 50-368, Poland. Electronic address:

End-stage renal disease chronic itch is a frequent symptom that bothers patients with advanced stages of chronic kidney disease. The pathogenesis of the chronic itch symptom is complex and not yet fully understood and includes many metabolic, immunologic, and neurogenic factors. A significant burden of the disease results in decreased quality of life with sleep impairment, depressive symptoms, and increased mortality of affected individuals. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.007DOI Listing
July 2018
17 Reads

Pruritus in Autoimmune Connective Tissue Diseases.

Dermatol Clin 2018 Jul 26;36(3):267-275. Epub 2018 Apr 26.

Department of Dermatology, King Khalid University, College of Medicine, PO Box 641, Abha 61421, Saudi Arabia. Electronic address:

Pruritus in autoimmune connective tissue diseases is a common symptom that can be severe and affect the quality of life of patients. It can be related to disease activity and severity or occur independent of the disease. Appropriate therapy to control the itch depends on the etiology, and it is therefore essential to first work-up these patients for the underlying trigger. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.013DOI Listing
July 2018
1 Read

Pruritus in Pregnancy and Its Management.

Authors:
Mark A Bechtel

Dermatol Clin 2018 Jul 26;36(3):259-265. Epub 2018 Apr 26.

Division of Dermatology, Ohio State University College of Medicine, 540 Officenter Place, #240, Gahanna, OH 43230, USA. Electronic address:

Pruritus in pregnancy can be a source of significant discomfort in the pregnant patient. Some cases are associated with pregnancy-specific dermatoses, although some patients experience a flare of a preexisting dermatosis. Severe pruritus may be a manifestation of a pregnancy-specific dermatosis associated with increased fetal risks and complications. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.012DOI Listing
July 2018
10 Reads

Pruritus in Cutaneous T-Cell Lymphoma and Its Management.

Dermatol Clin 2018 Jul;36(3):245-258

Department of Dermatology, Northwestern University, Feinberg School of Medicine, 676 North Saint Clair Street, Suite 1765, Chicago, IL 60611, USA. Electronic address:

Pruritus is a common symptom in cutaneous T-cell lymphoma (CTCL) and critically affects the quality of life of patients. Understanding the pruritogenesis has led to development of new therapeutic agents with promising outcomes in management of this recalcitrant symptom. Clinical assessments are warranted to aid in evaluation of treatment response or disease recurrence. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.011DOI Listing
July 2018
4 Reads

Female Genital Itch.

Dermatol Clin 2018 Jul 26;36(3):225-243. Epub 2018 Apr 26.

Department of Dermatology, Wake Forest University School of Medicine, 4618 Country Club Road, Winston-Salem, NC 27104, USA. Electronic address:

Vulvar pruritus is a common complaint among young girls and women presenting to primary care physicians, gynecologists, and dermatologists. Female genital itch is especially disruptive because of its interference with sexual function and intimacy. Causes of vulvar itch are vast and may be inflammatory, environmental, neoplastic, or infectious, often with several causes coexisting simultaneously. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183001
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http://dx.doi.org/10.1016/j.det.2018.02.006DOI Listing
July 2018
10 Reads

Diagnosis and Management of Neuropathic Itch.

Dermatol Clin 2018 Jul 26;36(3):213-224. Epub 2018 Apr 26.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 Northwest 12th Avenue, Miami, FL 33136, USA; Miami Itch Center, University of Miami Miller School of Medicine, 1475 Northwest 12th Avenue, Miami, FL 33136, USA. Electronic address:

Neuropathic pruritus is a challenging condition that can be caused by injury or dysfunction in any part of the nervous system. A vast array of clinical pictures exist, including both localized and generalized pruritus, and their principal entities are described in this article. Diagnosis is often difficult and depends on patient history, imaging, and neurophysiologic studies. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.005DOI Listing
July 2018
1 Read

Chronic Pruritus in the Geriatric Population.

Dermatol Clin 2018 Jul 20;36(3):199-211. Epub 2018 Mar 20.

Department of Dermatology and Cutaneous Surgery, Itch Center Miller School of Medicine, 1295 NW 14th Street, University of Miami Hospital South Building Suites K-M, Miami, FL 33125, USA.

Chronic pruritus (>6 week's duration) in the geriatric population (≥65 years old), is an increasing health care problem. The pathophysiologic predisposing factors are abnormalities of the epidermal barrier, immune system, and nervous system. Causes can be dichotomized into histaminergic and nonhistaminergic pruritus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338635183001
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http://dx.doi.org/10.1016/j.det.2018.02.004DOI Listing
July 2018
25 Reads
1.434 Impact Factor

Prurigo Nodularis and Its Management.

Dermatol Clin 2018 Jul 20;36(3):189-197. Epub 2018 Mar 20.

Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Von- Esmarch-Strasse 58, Münster DE-48149, Germany.

Prurigo nodularis occurs with chronic pruritus and the presence of single to multiple symmetrically distributed, hyperkeratotic, and intensively itching nodules. Diverse dermatologic, systemic, neurologic, or psychiatric conditions can lead to prurigo nodularis. Structural analysis demonstrated a reduced intraepidermal nerve fiber density and increased dermal levels of nerve growth factor and neuropeptides such as substance P and calcitonin gene-related peptide. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.003DOI Listing
July 2018
15 Reads

Diagnostic Work-up of the Itchy Patient.

Dermatol Clin 2018 Jul 27;36(3):179-188. Epub 2018 Apr 27.

Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

Pruritus is a common and troubling symptom associated with many dermatologic, systemic, neurologic, or psychiatric disorders. This article reviews the current understanding of the pathogenesis of itch and offers a differential diagnosis for the causes of chronic pruritus. The article discusses key diagnostic steps and considerations when evaluating patients with chronic pruritus. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.002DOI Listing
July 2018
1 Read

Pathophysiology of Itch.

Authors:
Ethan A Lerner

Dermatol Clin 2018 Jul 20;36(3):175-177. Epub 2018 Mar 20.

Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

Chronic itch is a clinically challenging yet scientifically remarkable and complex process. Increasing understanding of the pathophysiology of chronic itch is leading to targeted therapeutic approaches that are now dramatically improving quality of life. This improvement will accelerate as the tools of basic and clinical research continue to be applied to this previously intractable problem. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022764PMC
July 2018
1 Read

Complexities of Rosacea.

Dermatol Clin 2018 Apr 16;36(2):xiii. Epub 2017 Nov 16.

Wake Forest Baptist Medical Center, 1 Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA. Electronic address:

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http://dx.doi.org/10.1016/j.det.2017.11.014DOI Listing
April 2018
5 Reads

Measurement of Disease Severity in a Population of Rosacea Patients.

Dermatol Clin 2018 Apr 16;36(2):97-102. Epub 2017 Dec 16.

Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.

Severity of rosacea in populations is not well characterized. A validated self-assessment tool was used to study the relationship between rosacea severity and demographic factors. Subjects were adult patients with a clinical diagnosis of rosacea. Read More

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http://dx.doi.org/10.1016/j.det.2017.11.004DOI Listing
April 2018
7 Reads
1.434 Impact Factor

Validity and Reliability of a Rosacea Self-Assessment Tool.

Dermatol Clin 2018 Apr 28;36(2):93-96. Epub 2017 Nov 28.

Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA; Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.

The lack of validated rosacea assessment tools is a hurdle in assessing rosacea severity. This article discusses a valid and reliable rosacea severity self-assessment tool (RSAT) to measure rosacea severity. To determine test-retest validity, participants completed the self-assessment twice. Read More

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http://dx.doi.org/10.1016/j.det.2017.11.003DOI Listing
April 2018
8 Reads
1.434 Impact Factor