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    1831 results match your criteria Dermatofibrosarcoma Protuberans

    1 OF 37

    The management of soft tissue tumours of the abdominal wall.
    Eur J Surg Oncol 2017 May 6. Epub 2017 May 6.
    The Sarcoma Unit, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom. Electronic address:
    Background: Soft tissue tumours of the abdominal wall account for approximately 10% of all soft tissue tumours. Tumours at this site comprise a heterogeneous group of pathologies with distinct clinical behaviours and responses to treatment. The management of these tumours has largely been extrapolated from studies of soft tissue tumours at other sites. Read More

    Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans.
    Mol Clin Oncol 2017 May 17;6(5):665-668. Epub 2017 Mar 17.
    Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
    Dermatofibrosarcoma protuberans (DFSP) is a locally invading tumor, characterized by the presence of the collagen type I α 1 (COL1A1)-platelet-derived growth factor (PDGF) β fusion gene. We herein report the case of a 31-year-old man with a history of resection of an abdominal wall DFSP. The patient presented with chest pain and a computed tomography scan revealed a large mass in the posterior mediastinum and another mass in the right lung. Read More

    Dermatofibrosarcoma protuberans: when the age makes the difference.
    G Ital Dermatol Venereol 2017 May 16. Epub 2017 May 16.
    Dermatological Clinic, La Sapienza- Università di Roma, Rome, Italy.
    Background: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low- grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients. Read More

    Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas.
    Radiographics 2017 May-Jun;37(3):797-812
    From the Department of Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (A.D.L., M.A.M.); the American Institute for Radiologic Pathology, Silver Spring, Md (M.A.M.); and the Center of Cancer Research, National Cancer Institute, Bethesda, Md (M.M.M.).
    Soft-tissue sarcomas occurring in the abdomen and pelvis are an uncommon but important group of malignancies. Recent changes to the World Health Organization classification of soft-tissue tumors include the movement of gastrointestinal stromal tumors (GISTs) into the soft-tissue tumor classification. GIST is the most common intraperitoneal sarcoma. Read More

    A Review of the Global Guidelines on Surgical Margins for Nonmelanoma Skin Cancers.
    J Clin Aesthet Dermatol 2017 Apr;10(4):37-46
    Ohio State University Wexner Medical Center, Columbus, Ohio.
    Background: Adequate treatment and follow-up of a patient with nonmelanoma skin cancer is of utmost concern for a clinician. However, there is a lack of international consensus on recommendations for surgical excision margins. Furthermore, lack of familiarity of the published guidelines leads to a variety in practice styles. Read More

    Dermatofibrosarcoma Protuberance of the Breast: a Diagnostic Challenge.
    Indian J Surg 2017 Apr 16;79(2):169-172. Epub 2016 May 16.
    Department of Pathology, Hospital Tuanku Jaafar, Jalan Rasah, Seremban, 70300 Malaysia.
    Dermatofibrosarcoma protuberans (DFSP) is an uncommon slow growing neoplasm of the dermis with tendency to invade the subcutaneous tissues. It presents during the third to fourth decade of life and is commonly seen over the trunk, extremities and head and neck. DFSP presenting as a breast lump is rare but few cases have been reported in the literature. Read More

    [A tumour mistaken for a scar].
    Ned Tijdschr Geneeskd 2017 ;161(0):D707
    Amphia Ziekenhuis, afd. Dermatologie, Breda.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a rare type of cutaneous soft tissue sarcoma. The tumour metastasises rarely, but the percentage of recurrences is high and the tumour can be locally very aggressive.

    Case Description: A 50-year-old man was referred to our clinic for a long existing scar on his back, which had become painful in the last few weeks. Read More

    Subcutaneous dermatofibrosarcoma protuberans, a rare subtype with predilection for the head: A retrospective series of 18 cases.
    J Am Acad Dermatol 2017 Apr 15. Epub 2017 Apr 15.
    Dermatology Department, Instituto Valenciano de Oncologia, Valencia, Spain.
    Background: Dermatofibrosarcoma protuberans (DFSP) typically affects the dermis and subcutaneous tissue. The subcutaneous variant is rare.

    Objective: We sought to characterize the subcutaneous DFSP (SC-DFSP) variant and compare it with cutaneous DFSP (C-DFSP). Read More

    Non-melanoma skin cancer: new and future synthetic drug treatments.
    Expert Opin Pharmacother 2017 May 17;18(7):689-699. Epub 2017 Apr 17.
    a Center for Dermatooncology, Department of Dermatology , University Hospital Tübingen , Tübingen , Germany.
    Introduction: Non-melanoma skin cancers (NMSC) mainly comprise two different entities: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC); beneath these two entities, Merkel cell carcinoma, adnexal tumors, dermatofibrosarcoma protuberans, angiosarcoma, and cutaneous lymphoma belong to NMSC. These rare skin tumors are not the topic of this review. BCC and SCC are the most common cancers diagnosed in humans. Read More

    Breast and pleuropulmonary metastasis of multirecurrent scalp dermatofibrosarcoma protuberans: a case report.
    J Med Case Rep 2017 Apr 8;11(1):96. Epub 2017 Apr 8.
    Unité de Recherche en Sciences de la Santé, Université Ouaga I Professeur Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
    Background: Dermatofibrosarcoma protuberans is a rare tumor, representing about 0.1% of skin malignant tumors. It is characterized by local aggressiveness with significant potential for recurrence. Read More

    Long-term results of treatment of advanced dermatofibrosarcoma protuberans (DFSP) with imatinib mesylate - The impact of fibrosarcomatous transformation.
    Eur J Surg Oncol 2017 Jun 22;43(6):1134-1141. Epub 2017 Mar 22.
    Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center, Institute of Oncology, Warsaw Poland.
    Background: Dermatofibrosarcoma protuberans (DFSP) is rare, infiltrating dermal neoplasm, characterized by indolent growth and low probability of metastases. The first effective systemic therapy in DFSP introduced into clinical practice was imatinib, demonstrating high activity in advanced cases. The aim of the study was to perform an analysis of patients with advanced DFSP treated with imatinib, with or without surgery, in routine clinical practice with long-term follow-up. Read More

    Dermatofibrosarcoma Protuberans: An Immunomarker Study of 57 Cases That Included Putative Mesenchymal Stem Cell Markers.
    Appl Immunohistochem Mol Morphol 2017 Mar 30. Epub 2017 Mar 30.
    *Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center †VHS Medical Center, Seoul, Korea.
    Dermatofibrosarcoma protuberans (DFSP) is a low-grade fibroblastic sarcoma with a superficial location that has been suggested to potentially be a type of mesenchymal stem cell tumor. We studied the expression of various immunomarkers, including putative stem cell markers, in a series of 57 DFSPs including variants, and 12 dermatofibromas (DFs). CD105, a mesenchymal stem cell marker, was weakly expressed in 24 DFSPs, whereas other stem cell markers, including CD133, ALK-1, and Oct3/4, were completely negative in all samples. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: When is imaging necessary?
    J Am Acad Dermatol 2017 Apr;76(4):591-607
    Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.
    When treating aggressive skin cancers, pre- and postoperative imaging provides important information for treatment planning and multidisciplinary cooperation of care. It is important for dermatologists to recognize the clinical scenarios where imaging is indicated in the management of skin cancer. We here address the most common indications for imaging in cutaneous oncology and how to best utilize the modalities available. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: Diagnostic modalities and applications.
    J Am Acad Dermatol 2017 Apr;76(4):579-588
    Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:
    While uncomplicated cases of nonmelanoma skin cancer can be treated with surgery, destruction, or topical therapy alone, advanced or neglected cases require more complex management decisions. Dermatologists and dermatologic surgeons should be familiar with the imaging techniques relevant to cutaneous oncology and their value in different clinical scenarios. Herein we review imaging modalities used in management of nonmelanoma skin cancer. Read More

    Clinical Features and Treatment of Dermatofibrosarcoma Protuberans Affecting the Vulva: A Literature Review.
    Dermatol Surg 2017 Mar 17. Epub 2017 Mar 17.
    *Department of Medicine, Division of Dermatology, Creighton University School of Medicine, Omaha, Nebraska; †Department of Biology, Loyola Marymount University, Los Angeles, California.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a low-to-intermediate grade cutaneous neoplasm with a low propensity for metastasis and a high rate of local recurrence. It typically presents as a dermal plaque or nodule on the trunk, limbs, or head and neck region. Vulvar DFSP has also been described, although it is less common. Read More

    Perspectives on Low-grade Sarcomas: The Extraordinary Contributions of Sharon W. Weiss, MD.
    Adv Anat Pathol 2017 Mar 13. Epub 2017 Mar 13.
    *Department of Pathology, MetroHealth Medical Center/Case Western Reserve University †Department of Pathology, Cleveland Clinic, Cleveland, OH.
    Soft-tissue pathology encompasses a wide spectrum of neoplasms that represent some of the most challenging and problematic tumors in surgical pathology. Owing to the intensive work of dedicated pathologists, this once esoteric field has become increasingly well defined. In this review, Dr Sharon Weiss' monumental contributions to low-grade sarcomas, including low-grade fibromyxoid sarcoma/so-called hyalinizing spindle cell tumor, atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma, epithelioid hemangioendothelioma, and dermatofibrosarcoma protuberans with fibrosarcomatous transformation will be discussed. Read More

    Differential diagnosis of acute miliary pulmonary tuberculosis from widespread-metastatic cancer for postoperative lung cancer patients: two cases.
    J Thorac Dis 2017 Feb;9(2):E115-E120
    Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, Chengdu 610041, China; State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu 610041, China.
    Pulmonary infections and lung cancer can resemble each other on radiographic images, which makes it difficult to diagnosis accurately and apply an appropriate therapy. Here we report two cases that two postoperative patients with lung adenocarcinoma developed diffuse nodules in bilateral lungs in a month which needed to be distinguished between metastatic malignancies and infectious diseases. Although there are much similarities in disease characteristics of two cases, patient in case one was diagnosed as acute miliary pulmonary tuberculosis (TB) while patient in case two was diagnosed as metastatic disease. Read More

    Application of COL1A1-PDGFB fusion gene detection by fluorescence in situ hybridization in biopsy tissue of dermatofibrosarcoma protuberans.
    J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
    Several uncommon variants of dermatofibrosarcoma protuberans (DFSP) and the limitations of small biopsies render pathological diagnosis difficult. The aim of this study was to analyze the utility of fluorescence in situ hybridization (FISH) in the detection of the collagen type I-α1/platelet derived growth factor-β (COL1A1-PDGFB) fusion gene in biopsies of DFSP. Twenty-three consecutive biopsy specimens of DFSP were reviewed for clinicopathological features and examined with the COL1A1-PDGFB fusion probe and PDGFB break-apart probe using FISH analysis. Read More

    Association of patient demographic characteristics with Dermatofibrosarcoma Protuberans tumor size at diagnosis in the National Cancer Data Base.
    Br J Dermatol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Dermatology, University of Arizona College of Medicine, Phoenix, AZ.
    Dermatofibrosarcoma protuberans (DFSP) is a rare, infiltrative but low-grade cutaneous tumor. Middle-aged and younger adults, males, and African-Americans are more likely to be affected by this malignancy, with up to 5 cases per million reported annually in the US. Despite its low metastatic potential and excellent survival, DFSP is prone to recurrence and can be very locally destructive. Read More

    Sclerosing Dermatofibrosarcoma Protuberans Shows Significant Overlap With Sclerotic Fibroma in Both Routine and Immunohistochemical Analysis: A Potential Diagnostic Pitfall.
    Am J Dermatopathol 2017 Feb;39(2):83-88
    Departments of *Dermatology, and †Pathology, University of California San Francisco, San Francisco, CA.
    Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-to-intermediate grade sarcoma with several histologic variants, including pigmented (Bednar tumor), sclerosing, myxoid, atrophic, and DFSP with fibrosarcomatous changes. Two patterns of sclerosis in DFSP can be observed, a sclerotic fibroma-like pattern and a morphea/lichen sclerosus-like pattern. Partial biopsies of sclerosing DFSPs with the sclerotic fibroma pattern can be misdiagnosed as sclerotic fibroma or other benign sclerosing tumors (eg, perineurioma, dermatofibroma). Read More

    Imatinib in Dermatofibrosarcoma: Targeted Therapy or Immunotherapy?
    J Invest Dermatol 2017 Feb;137(2):277-279
    Department of Dermatology, University of Duisburg-Essen, Essen, Germany; Translational Skin Cancer Research, German Cancer Consortium, West German Cancer Center, Essen, Germany. Electronic address:
    There is increasing evidence that certain kinase inhibitors are able to foster two strategies, i.e. inhibition of oncogenic activated molecular pathways and modulation of immunological processes. Read More

    Unusual Signal Patterns of Break-apart FISH Probes Used in the Diagnosis of Soft Tissue Sarcomas.
    Pathol Oncol Res 2017 Jan 20. Epub 2017 Jan 20.
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary.
    Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Read More

    A single-institutional review of 68 patients with dermatofibrosarcoma protuberans: wide re-excision after inadequate previous surgery results in a high rate of local control.
    World J Surg Oncol 2017 Jan 5;15(1). Epub 2017 Jan 5.
    Department of Plastic Surgery, Burn Centre, Hand Centre, BG-University Hospital Bergmannsheil, Buerkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a cutaneous soft tissue sarcoma characterized by an indolent but aggressive local growth. Unplanned excisions with positive margins are common, and the prognostic impact of radical re-excisions is still unclear. The aim of the present study was to identify prognostic indicators of recurrence-free survival (RFS) in patients with DFSP through a long-term follow-up. Read More

    Superficial Acral Fibromyxoma: Report of 13 Cases With New Immunohistochemical Findings.
    Am J Dermatopathol 2017 Jan;39(1):14-22
    *Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; †Department of Pathology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain; and ‡Dermatopathology Laboratory, Friedrichschafen, Germany.
    Background: Superficial acral fibromyxoma (SAF) is a benign, soft tissue neoplasm preferably located on the digits.

    Methods: We collected 13 cases of SAF and evaluated their clinical, histopathologic, and immunohistochemical features.

    Results: This study included 9 males and 4 females, median age 54 years. Read More

    Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
    Dermatol Surg 2017 Jan;43(1):116-124
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

    Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

    Nodular Fasciitis Complicating a Staged Surgical Excision of Dermatofibrosarcoma Protuberans.
    Case Rep Dermatol Med 2016 27;2016:6074182. Epub 2016 Nov 27.
    Department of Dermatology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
    Dermatofibrosarcoma protuberans (DFSP) is an unusual spindle cell tumor with a high rate of local recurrence with traditional excision. Fortunately, Mohs micrographic surgery yields excellent cure rates for this neoplasm due to contiguous tumor spread and meticulous tumor mapping and margin analysis. We present the unique case of a patient treated with a modified Mohs technique with an analysis of the final margin with permanent sections, who developed a spindle cell neoplasm in the margins of her second stage excision consistent with nodular fasciitis. Read More

    Dermatofibroma of the eyelid with monster cells.
    Surv Ophthalmol 2016 Dec 22. Epub 2016 Dec 22.
    Department of Dermatology, Massachusetts General Hospital.
    Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A recurrent lesion of the right lower eyelid developed in a 64-year-old woman. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted, and hyperchromatic nucleus. Read More


    Dermatofibrosarcoma Protuberans-Like Tumor With COL1A1 Copy Number Gain in the Absence of t(17;22).
    Am J Dermatopathol 2017 Apr;39(4):304-309
    *Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY; †Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY; and ‡Department of Medicine, Memorial Sloan Kettering Cancer Center and Department of Medicine, Weill Cornell Medical College, New York, NY.
    A 57-year-old woman presented with a 3-year history of a progressive firm plaque on the right cheek. Skin biopsies revealed a bland, storiform, spindle-cell proliferation involving the deep dermis and subcutaneous fat. By immunohistochemistry, the tumor cells were diffusely positive for CD34 and caldesmon with multifocal reactivity for epithelial membrane antigen and focal, weak staining for smooth muscle actin. Read More

    [What surgery for recurrent Darier-Ferrand sarcoma of the chest wall?]
    Rev Pneumol Clin 2017 Apr 12;73(2):100-105. Epub 2016 Dec 12.
    Service de chirurgie thoracique C1, CHU Hassan II, Fès, Maroc; Faculté de médecine et de pharmacie, université Sidi-Mohamed-Ben-Abdellah, Fès, Maroc.
    Introduction: Dermatofibrosarcoma protuberans (Darrier-Ferrand sarcoma, DFSP) is an uncommon tumor. This sarcoma has a tendency to local recurrence, requiring a wide surgical resection.

    Observation: We report herein two cases of patients presenting with recurrent dermatofibrosarcoma protuberans after several surgical resections. Read More

    Mohs micrographic surgery of rare cutaneous tumours.
    J Eur Acad Dermatol Venereol 2016 Dec 15. Epub 2016 Dec 15.
    Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
    Background: Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.

    Objective: To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.

    Methods & Materials: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. Read More

    Incidence and Outcomes of Dermatofibrosarcoma Protuberans in the US Pediatric Population.
    J Craniofac Surg 2017 Jan;28(1):182-184
    *DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL †New York Medical College, New York, NY ‡Division of Plastic, Aesthetic, and Reconstructive Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, FL.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a low-grade soft tissue sarcoma. In the pediatric population, DFSP is exceedingly rare. Aim of this study was to describe the epidemiology and clinical outcomes in a large pediatric cohort. Read More

    Dermatofibrosarcoma protuberans: a case report and review of the literature.
    Hippokratia 2016 Jan-Mar;20(1):80-83
    1st Propedeutic Surgical Department, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background: Dermatofibrosarcoma protuberans (DFSP) represents less than 0.1% of all tumors, but it is considered the most common skin sarcoma. Wide local excision (=5 cm) has been largely replaced by Mohs micrographic surgery; however, recurrence is not rare. Read More

    Atypical Spindle Cell Lipomatous Tumor: Clinicopathologic Characterization of 232 Cases Demonstrating a Morphologic Spectrum.
    Am J Surg Pathol 2017 Feb;41(2):234-244
    *Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA †Department and Graduate Institute of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    The classification of atypical adipocytic neoplasms with spindle cell features remains challenging. To better define this category of low-grade lipomatous neoplasms, we present herein the clinical, histologic, and immunohistochemical characteristics of a large series of 232 atypical spindle cell lipomatous tumors. The lesions affected 140 males and 92 females, at an average age of 54 years (range, 6 to 87 y), clinically presenting as a persistent or enlarging mass with a median size of 5 cm. Read More

    Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies.
    Ann Diagn Pathol 2016 Dec 27;25:64-71. Epub 2016 Sep 27.
    Sarcoma Unit, Royal Marsden Hospital, London, United Kingdom.
    Dermatofibrosarcoma protuberans (DFSP), the most common dermal sarcoma, is a malignant fibroblastic tumor most frequently arising in middle-aged adults. It is typically a low-grade sarcoma that grows slowly but has a high rate of local recurrence with low metastatic potential. Dermatofibrosarcoma protuberans is characterized by a specific translocation t(17;22)(q22;q13) leading to the formation of COL1A1-PDGFB fusion transcripts. Read More

    A Tete - a - tete of benign, borderline and malignant fibrohistiocytic tumor.
    Iran J Pathol 2016 ;11(3):286-290
    Dept. of Surgery, Sri Siddhartha Medical College, Tumkur, Karnataka - 572104, India.
    Dermatofibrosarcoma protruberans is a relatively uncommon slow growing, locally aggressive fibrous tumor of the skin. It has a prospensity of progressing to fibrosarcomatous change in 5% of the cases. We present a case of a 56 yr old male with presented to the outpatient department of surgery, Sri Siddhartha Medical College, Tumkur with a chest swelling in 2013. Read More

    Adaptive Immunity in Fibrosarcomatous Dermatofibrosarcoma Protuberans and Response to Imatinib Treatment.
    J Invest Dermatol 2017 Feb 5;137(2):484-493. Epub 2016 Sep 5.
    Unit of Immunotherapy of Human Tumors, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:
    Dermatofibrosarcoma protuberans (DFSP), although rare, is the most frequent skin sarcoma. Here, we focus on DFSP carrying the fibrosarcomatous transformation (FS-DFSP). FS-DFSP responds to imatinib (IM); however, tumor relapse often occurs. Read More

    Dermatofibrosarcoma Protuberans: A comprehensive review on the spectrum of clinico-radiological presentations.
    J Med Imaging Radiat Oncol 2017 Feb 18;61(1):9-17. Epub 2016 Oct 18.
    Department of Radiology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.
    Dermatofibrosarcoma Protuberans (DFSP) is a rare malignant soft-tissue neoplasm which is often misdiagnosed due to its indolent clinical course and non-specific radiological appearances. An observation case series was conducted with retrospective review of clinical and radiological data of DFSP patients presenting to a major tertiary hospital in Hong Kong for radiological assessment between November 2006 and February 2016. Seven patients with confirmed histological diagnosis of DFSP were included. Read More

    A Comparison of Mohs Micrographic Surgery and Wide Local Excision for Treatment of Dermatofibrosarcoma Protuberans With Long-Term Follow-up: The Mayo Clinic Experience.
    Dermatol Surg 2017 Jan;43(1):98-106
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota; †Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minnesota.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a soft tissue tumor with slow infiltrative growth and local recurrence if inadequately excised.

    Objective: To compare long-term outcomes after Mohs micrographic surgery (MMS) and wide local excision (WLE).

    Materials And Methods: Records of patients with DFSP surgically treated with WLE or MMS from January 1955 through March 2012 were retrospectively reviewed. Read More

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