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Dermatol Surg 2020 Jul 31. Epub 2020 Jul 31.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Am J Dermatopathol 2020 Jul 23. Epub 2020 Jul 23.

Department of Dermatology, IRCCS INRCA, Ancona, Italy.

Rev Chil Pediatr 2020 Feb 3;91(1):99-104. Epub 2019 Dec 3.

Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Introduction: Bednar tumor is a rare low-grade sarcoma considered the pigmented variant of dermatofibrosarco ma protuberans (DFSP).

Objective: To describe the clinical and histopathological characteristics, treatment and evolution of this rare neoplasm.

Clinical Case: A 9-year old female presented with a 2-year history of an indurated, asymptomatic papule on the back of her fourth left toe. Read More

J Dermatol 2020 Jul 28. Epub 2020 Jul 28.

Department of Plastic and Reconstructive Surgery, Seoul National University Boramae Hospital, Seoul National University College of Medicine, Seoul, Korea.

Clin Case Rep 2020 Jul 16;8(7):1192-1194. Epub 2020 Apr 16.

Student Research Committee Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.

We present a typical case of dermatofibrosarcoma protuberans(DFSP) with a complaint of a painful and various recurrence, make a review of the most important aspects. This is a rare tumor and we call special attention to the fact that its recurrence is extremely frequent, so there is absolute need to observe these patients periodically after surgery. Read More

Dermatol Ther 2020 Jun 17:e13853. Epub 2020 Jun 17.

Department of dermatology, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, China.

Acta Dermatovenerol Croat 2020 Jul;28(1):49-50

Dear Editor, Desmoplastic melanoma (DM) is a rare histological subtype of melanoma, usually presenting as a slowly-growing, amelanotic, discoid, and/or firm lesion composed of spindle cells with abundant collagen (1). It is more common on sun-exposed areas, especially on head and neck in elderly patients (2). Regional lymph node involvement is reported to be less frequent than in other cutaneous melanomas (3). Read More

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

Department of Dermatology, Baylor College of Medicine, Houston, TX.

Mohs micrographic surgery (MMS) is a breakthrough surgical technique that has changed the management of neoplasms in dermatology. Through continued practice and evolution, MMS now can successfully treat a variety of rare non-melanocytic cutaneous malignancies for which achieving remission and the optimal aesthetic result after surgery was previously challenging. Mohs micrographic surgery has utility for conditions besides melanoma. Read More

Curr Probl Diagn Radiol 2020 Jun 1. Epub 2020 Jun 1.

Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Dermatofibrosarcoma protuberans (DFSP) is a rare, low-to-intermediate grade sarcoma that typically arises in the dermis and infiltrates subcutaneous tissue. Due to superficial appearance of DFSP, imaging techniques are not always utilized. However, they may be useful in large or atypical cases. Read More

JAAD Case Rep 2020 Jul 19;6(7):606-607. Epub 2020 May 19.

Pediatric Dermatology Unit, Department of Medicine (DIMED), University of Padova, Padova, Italy.

Br J Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Standard treatment in the United Kingdom (UK) is either surgical wide local excision (WLE) or Mohs micrographic surgery (MMS). It is unclear which approach has the lower recurrence rate. Read More

J Plast Reconstr Aesthet Surg 2020 Jun 13. Epub 2020 Jun 13.

Unit of Plastic and Reconstructive Surgery, Federico II University of Naples, Italy.

Eur J Dermatol 2020 Jun;30(3):289-293

Department of Health Science, University of Eastern Piedmont, Novara.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare, locally infiltrating, rarely metastasizing, soft tissue tumour. Due to its indistinct margins, local aggressive behaviour and high recurrence rate, the surgical approach is complex. Micrographic surgery and variants of this technique, e. Read More

Anal Cell Pathol (Amst) 2020 28;2020:8232803. Epub 2020 May 28.

Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored. Immunohistochemical analysis for TFE3 was performed on 50 cases of SFTs that were surgically resected. The controls were sample tissues from malignant peripheral nerve sheath tumour, synovial sarcoma, dedifferentiated liposarcoma, spindle cell lipoma, and dermatofibrosarcoma protuberans. Read More

Pediatr Blood Cancer 2020 Jun 18:e28351. Epub 2020 Jun 18.

Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Background: As dermatofibrosarcoma protuberans (DFSP) are rare with no prospective series within paediatric sarcoma trials, the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) examined the clinical data and outcomes of DFSP enrolled in a multinational study of non-rhabdomyosarcoma soft tissue sarcomas (NRSTS).

Patients And Methods: Forty-six patients with confirmed DFSP were enrolled into the EpSSG NRSTS 2005 study. All had surgical resection and none had any further therapy at diagnosis. Read More

Plast Reconstr Surg Glob Open 2019 Dec 12;7(12):e2528. Epub 2019 Dec 12.

Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo, Japan.

Dermatofibrosarcoma protuberans (DFSP) is a slow-growing superficial sarcoma. Due to its high late local recurrence, thin skin graft is usually recommended for reconstruction after resection of the tumor. In this report, we present a case of giant DFSP in the groin region of young woman. Read More

Int J Health Sci (Qassim) 2020 May-Jun;14(3):18-25

Department of Pathology, Government Medical College, Miraj, Maharashtra, India.

Objective: Skin cancers are relatively uncommon malignancies worldwide, but there is a progressive increase in the incidence over the last few decades.

Methods: We have studied the clinical and histopathological features of malignant skin tumors received in the department of pathology of our tertiary care institute over a period of 3 years and 8 months. A detailed analysis of clinical, gross, and microscopic findings was performed, followed by clinicopathological correlation. Read More

Cytopathology 2020 Jun 13. Epub 2020 Jun 13.

Department of Pathology, Chacha Nehru Bal Chikitsalaya, Delhi, India.

J Cutan Pathol 2020 Jun 10. Epub 2020 Jun 10.

Department of Pathology, NYU Langone Medical Center, New York, New York, USA.

We present the case of a 31-year-old female with a 1.5 cm pigmented nodule on the scalp. Histopathological examination revealed a proliferation of relatively bland spindle cells and pigmented dendritic cells, with interspersed lymphoid follicles diffusely infiltrating the adipose tissue. Read More

J Cutan Pathol 2020 Jun 9. Epub 2020 Jun 9.

Department of Pediatrics and Pathology, Saint Louis University Medical School, St. Louis, Missouri, USA.

Dermatofibrosarcoma protuberans (DFSP) is a rare sarcoma of the skin arising from the dermis. Its location is most commonly presented on the trunk of middle-aged adults and rarely on the face. The characteristic genetic aberration in the form of a reciprocal translocation t(17;22)(q21;q13) or a ring fusing the COL1A1 and PDGFB genes is found in 90% of DFSP. Read More

J Clin Med 2020 Jun 5;9(6). Epub 2020 Jun 5.

Department of Dermatology, Cleveland Clinic, Cleveland, OH 44195, USA.

Dermatofibrosarcoma protuberans (DFSP) is a slow growing, low- to intermediate-grade dermal soft-tissue tumor. It has a high local recurrence rate but low metastatic potential. It is characterized by a uniform spindle cell arrangement, classically with a storiform pattern and CD34 immunoreactivity. Read More

J Cutan Pathol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA.

Background: Malignant tumor of the vulva is the fourth gynecological malignancy in frequency. Close to 70% of all vulvar malignancies are related to high-risk human papillomavirus (HPV) infection.

Methods: A search for non-HPV-related malignant tumors of the vulva was performed in the last 20 years (2000-2020) in the pathology database of a single tertiary institution. Read More

Fetal Pediatr Pathol 2020 Jun 8:1-8. Epub 2020 Jun 8.

Department of Pathology, Institute of Postgraduate Medical Education and Research, Kolkata, India.

Giant cell fibroblastoma (GCF) shows a wide spectrum of morphological patterns which may lead to a misdiagnosis of sarcoma. This 14- month- old baby was referred to us for recurrent left scrotal embryonal rhabdomyosarcoma (ERMS), first diagnosed at 8 months, status post chemotherapy. Review of previous histology, cytology (with frequent multinucleated floret type giant cells but without cross striations) and immunohistochemistry resulted in the change of diagnosis to GCF. Read More

JAAD Case Rep 2020 Jun 1;6(6):558-560. Epub 2020 May 1.

The Facial Plastics and Dermatology Department, The Toledo Clinic, Toledo, Ohio.

Cesk Patol 2020 ;56(2):89-93

Dermatofibrosarcoma protuberans is a quite rare local aggressive tumor of dermis and subcutis, revealing characteristic morphology and chromosomal translocation (17; 22)(q21;q13) with gene fusion COL1A1-PDGFB. The tumour almost never metastasizes and complete excision signs an excellent prognosis. Approximately in 10% of cases, dermatofibrosarcoma undergoes a fibrosarcomatous transformation associated with metastatic disease and worse prognosis. Read More

Clin Exp Dermatol 2020 May 27. Epub 2020 May 27.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Dermatofibrosarcoma protuberans (DFSP) is a rare neoplasm derived from fibroblasts and tumorigenic mechanism is mainly defined by the formation of a fusion gene between the α-helix domain of the collagen type 1 (COL1A1) gene and the platelet-derived growth factor-β (PDGFB) gene. We investigated the fusion site of COL1A1/PDGFB gene and its relationship with clinical findings in 30 patients with DFSP treated at our hospital. COL1A1/ PDGFB fusion was detected in 83% of DFSP patients. Read More

J Surg Oncol 2020 Aug 19;122(2):263-272. Epub 2020 May 19.

Klinikum Stuttgart-Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pediatrics 5 (Oncology, Hematology, Immunology), Stuttgart, Germany.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade tumor. Little is known about best treatment of primary and relapsed disease (RD).

Methods: Treatment and outcome of 40 patients with DFSP prospectively registered within the CWS-96 and -2002P trials and the registry SoTiSaR (1996-2016) were analysed. Read More

J Cutan Pathol 2020 May 15. Epub 2020 May 15.

Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.

Background: Cellular dermatofibromas (CDFs) and dermatofibrosarcoma protuberans (DFSP) can be challenging to differentiate from one another. Morphologically, both entities commonly extend into the subcutis, exhibit high cellularity with limited cytologic atypia and have a mixed fascicular-to-storiform growth pattern. We sought to evaluate the significance of fat necrosis with an associated lymphocytic infiltrate as a histopathologic clue for distinguishing CDFs from DFSP. Read More

Wien Med Wochenschr 2020 May 7. Epub 2020 May 7.

Onkoderma, Policlinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, 1606, Sofia, Bulgaria.

Background: Melanomas of the glans penis, prepuce, and the corpus of the penis account for less than 1% of all melanoma cases. Due to this rarity, there is currently no standard treatment approach.

Case Description: We present the case of a 59-year-old patient with tumorous formations in the prepuce area. Read More

J Cancer 2020 7;11(14):4081-4090. Epub 2020 Apr 7.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi 832002, China.

: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet-associated proteins that participate in lipid metabolism regulation. Read More

Hum Cell 2020 Jul 30;33(3):894-903. Epub 2020 Apr 30.

Division of Rare Cancer Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Dermatofibrosarcoma protuberans (DFSP) is the most common dermal sarcoma; it is characterized by the presence of the COL1A1-PDGFB translocation, which causes the constitutive activation of the platelet-derived growth factor β (PDGFB) signaling pathway. DFSP frequently exhibits local recurrence and is refractory to conventional chemotherapy. Therefore, a novel therapeutic strategy is required for improving the prognosis of DFSP. Read More

Folia Med (Plovdiv) 2020 Mar;62(1):17-22

Holy Cross Oncology Centre, Kielce, Poland.

We examined a status of fibrosarcoma arising in dermatofibrosarcoma protuberans of 64-year-old male patient. A dermal, solid, grayish-yellow, desmin-negative trichrome-bluish tumor measured 1.5 cm in diameter pT1a (edition 8 pTNM). Read More

J Am Osteopath Assoc 2020 May;120(5):362

Int J Surg Case Rep 2020 3;69:101-104. Epub 2020 Apr 3.

Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, United States. Electronic address:

Introduction: Dermatofibrosarcoma Protuberans (DFSP) is a rare type of malignant tumor of the cutaneous soft tissue that typically involves the dermis and surrounding structures. The typical clinical presentation involves an asymptomatic, slowly enlarging, indurated plaque, usually found on the trunk.

Presentation Of Case: Here we present an atypical presentation of DFSP in a patient with a recurrent mass that was initially diagnosed as a lipoma, with supporting literature and clinical considerations for post-surgical management DISCUSSION: In its earlier stages, DFSP can mimic other benign or malignant dermatological pathologies, which can complicate diagnosis purely via history and physical exam. Read More

Rev Med Suisse 2020 Apr;16(688):640-645

Département de dermatologie et vénéréologie, CHUV, 1011 Lausanne.

The dermatofibrosarcoma protuberans (DFSP) is the most common form of low-grade cutaneous sarcoma; its infiltrating growth occurs by fingerlike projections, which explain the high rate of recurrence in case of inappropriate surgical procedure. Based on an extensive review of the existing literature, we propose here to discuss the actual criteria for early recognition, diagnosis and optimal take of care of DFSP. Read More

Breast J 2020 Mar 29. Epub 2020 Mar 29.

Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Fibrosarcomatous transformation of dermatofibrosarcoma protuberans (DFSP) is a rare variant with higher risk of recurrence and metastasis, and no known associations with breast implants. We report a rare case of fibrosarcomatous dermatofibrosarcoma protuberans arising at the site of breast implant in a 33-year-old patient followed by brief discussion on fibrosarcomatous DFSP. Read More

J Dermatol 2020 Jun 24;47(6):e244-e246. Epub 2020 Mar 24.

Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan.

Indian J Surg Oncol 2020 Mar 21;11(1):35-40. Epub 2019 Nov 21.

2Department of Plastic & Reconstructive Surgery, Tata Medical Center, Kolkata, India.

Dermatofibrosarcoma protuberans (DFSP) is a slow growing dermal tumor with a very low metastatic potential but with significant subclinical extension and capacity for local destruction with local recurrence rates ranging from 0 to 50%. Controversy exists regarding margin width and excision techniques, with some advocating Mohs surgery and others wide excision. We reviewed the excision technique along with the recurrence rates at a tertiary care center in eastern India. Read More

J Plast Reconstr Aesthet Surg 2020 Jun 18;73(6):1143-1150. Epub 2020 Feb 18.

Department of Plastic and Reconstructive Surgery, Nanjing Drum Tower Hospital, 321 Zhong Shan Road, Nanjing, Jiangsu 210009, China. Electronic address:

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare dermal sarcoma characterised by low-grade malignancy, slow infiltrative growth, local recurrence and rare distant metastases.

Objective: Many international studies exist on DFSP, but limited data on Asian patients are available. This article fills this gap. Read More

Wien Med Wochenschr 2020 Mar 13. Epub 2020 Mar 13.

Special Office, Izmir, Turkey.

Dermatofibrosarcoma protuberans is a slowly progressive, locally aggressive fibroblastic tumor which can be misdiagnosed in the early stage. Reflectance confocal microscopic features of dermatofibrosarcoma protuberans has been scarcely described in the literature. We described the dermoscopic and reflectance confocal microscopic findings of 12 × 15 cm sized tumoral lesion of 45-year-old man. Read More

J Cutan Pathol 2020 Apr;47(4):317-320

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

Cir Esp 2020 Mar 7. Epub 2020 Mar 7.

Servicio de Dermatología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España.

Klin Onkol 2020 ;33(1):66-78

The Connective Tissue Oncology Group Annual Meeting 2018 (CTOS 2018) took place in Rome from 4 to 17 November 2018, and the 39th Plenary Meeting of the Scandinavian Sarcoma Group (SSGM 2019) was held in Bergen from 8 to 10 May 2019. These two large international conferences brought together an overwhelming majority of molecular and clinical specialists in the sarcoma field, especially those working on soft tissue sarcoma. Topics discussed on the conferences included, among others, sarcoma genetics, clinical and molecular subclassification, targeted therapy, clinical prognostication, and new experimental sarcoma models. Read More

Bull Cancer 2020 Mar 12;107(3):328-332. Epub 2020 Feb 12.

CHU de Sourô-Sanou, service de chirurgie générale et digestive, Bobo-Dioulasso, Burkina-Faso.

Introduction: Dermatofibrosarcoma (DFS) is a common dermic sarcoma. It is a local malignant tumor occurring in young adults. The recurrence potential justifies an R0-type surgery with a three centimeters margin. Read More

J Cosmet Dermatol 2020 Feb 10. Epub 2020 Feb 10.

Skin Diseases and Leishmaniasis Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare dermal mesenchymal tumor known as a low-grade, slow-growing malignancy. The local invasion and high rate of recurrence following surgical treatment are the main concerns to plan the best surgical approach of treatment.

Aims: In the current study, it is aimed to provide an experience of slow-Mohs surgery for the treatment of patients with DSFP. Read More

J Clin Aesthet Dermatol 2019 Dec 1;12(12):39-43. Epub 2019 Dec 1.

Dr. Foshee is with the Division of Dermatology, University of Arizona College of Medicine in Tucson, Arizona.

Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive tumor, uncommonly occurring on the head and neck where these deeply infiltrating tumors might violate underlying neurovascular structures. Treatment is typically surgical, whether by Mohs micrographic surgery (MMS) or wide local excision (WLE). However, there is a paucity of literature describing functional neurologic outcomes following surgical extirpation of facial DFSP. Read More

Zhonghua Shao Shang Za Zhi 2020 Jan;36(1):67-69

Department of Burns and Plastic Surgery, Dali Bai Autonomous Prefecture People's Hospital, Dali 671000, China.

On October 23, 2017, a 52-year-old male patient with 3 recurrences of dermatofibrosarcoma protuberans in the left shoulder and chest was admitted to the Department of Burns and Plastic Surgery of Dali Bai Autonomous Prefecture People's Hospital. Dermatofibrosarcoma protuberans on the skin were completely resected, leaving wound defect of 10 cm×10 cm. The wound was planned to be repaired by the transplantation of right anterolateral thigh perforator free flap. Read More

Eur Arch Otorhinolaryngol 2020 May 4;277(5):1473-1480. Epub 2020 Feb 4.

Department of Oral Pathology, Federal University of Rio Grande Do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande do Norte, CEP 59056-000, Brazil.

Purpose: This study aimed to analyze the demographics, clinicopathological, treatment, and survival characteristics of head and neck sarcomas diagnosed in a reference center in the Brazilian Northeast.

Materials And Methods: This retrospective cohort study reviewed the clinical records of patients with head and neck sarcomas. Epidemiologic data consisted in clinical location, age, gender, histopathological diagnosis, clinical TNM staging and treatment. Read More