1,999 results match your criteria Dermatofibrosarcoma Protuberans


Plaque-like myofibroblastic tumor, a rare entity of childhood: possible pitfalls in differential diagnosis.

J Cutan Pathol 2019 Feb 9. Epub 2019 Feb 9.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.

Plaque-like myofibroblastic tumor is a rare and benign pediatric soft tissue tumor. It presents as a slowly growing plaque reaching several centimeters in diameter, made up of multiple nodules. The clinical and histological features of this benign entity are similar to other fibrohistiocytic or myofibroblastic tumors occuring in childhood, so the diagnosis can be difficult. Read More

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http://dx.doi.org/10.1111/cup.13441DOI Listing
February 2019

Dermatofibrosarcoma protuberans: A rare and devastating tumor of the vulva.

Gynecol Oncol Rep 2019 May 25;28:9-11. Epub 2019 Jan 25.

Ohio State University James Cancer Hospital, Division of Gynecologic Oncology, United States.

•Biopsies of a large mass are prone to sampling errors and may lead to an incorrect diagnosis.•MRI imaging of vulvar tumors can aid in surgical planning.•Large sarcomas of the vulva require a multi-disciplinary approach. Read More

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http://dx.doi.org/10.1016/j.gore.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357686PMC

Giant Dermatofibrosarcoma Protuberans With Bilateral Orbital Involvement.

Ophthalmic Plast Reconstr Surg 2019 Jan 25. Epub 2019 Jan 25.

Departments of Ophthalmology and Visual Sciences.

Dermatofibroma sarcoma protuberans (DFSP) is a rare, locally aggressive soft tissue sarcoma with a tendency for recurrence after excision. Although reports of unilateral orbital and bilateral eyelid disease exist, there have been no prior reports of DFSP with bilateral orbital involvement and no previously described cases of DFSP associated with transient optic neuropathy. The authors present a case report of a 34-year-old woman with a giant scalp DFSP involving the bilateral orbits. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001308DOI Listing
January 2019

Dermatofibrosarcoma protuberans: Two rare variants.

Indian J Dermatol Venereol Leprol 2019 Mar-Apr;85(2):204-208

Department of Dermatology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_923_17DOI Listing
February 2019

A case of aggressive giant dermatofibrosarcoma protuberance occurring in the parotid gland.

Int J Surg Case Rep 2019 Jan 22;55:58-61. Epub 2019 Jan 22.

Head and Neck Oncology Center, Kazakh Institute of Oncology and Radiology, 91 Abay Ave, Almaty, Kazakhstan.

Introduction: Dermatofibrosarcoma protuberans (DFSP) is a cutaneous malignancy that arises from the dermis and invades deeper tissue. The cellular origin of DFSP is not clear. Evidence supports the cellular origin being fibroblastic, histiocytic, or neuroectodermal. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193000
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http://dx.doi.org/10.1016/j.ijscr.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351289PMC
January 2019
1 Read

Role of postoperative radiotherapy in dermatofibrosarcoma protuberans: a propensity score-matched analysis.

Radiat Oncol 2019 Jan 29;14(1):20. Epub 2019 Jan 29.

Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, 350014, China.

Objective: This study aimed to evaluate the role of postoperative radiotherapy (RT) in dermatofibrosarcoma protuberans (DFSP) and identify the prognostic factors influencing the disease-free survival (DFS).

Methods: A total of 184 patients with DFSP were analyzed from 2000 to 2016. The regression model was used to examine the prognostic factors for DFS. Read More

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http://dx.doi.org/10.1186/s13014-019-1226-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350344PMC
January 2019

STAT6 Expression in Solitary Fibrous Tumor and Histologic Mimics: a Single Institution Experience.

Appl Immunohistochem Mol Morphol 2019 Jan 19. Epub 2019 Jan 19.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

STAT6 stain has proved to be a good surrogate marker for the genetic alteration (NAB2-STAT6 gene fusion) in solitary fibrous tumor (SFT). This study aims to validate the use of STAT6 rabbit monoclonal antibody in differentiating SFT from its histologic mimics. Forty-five cases of SFT and 110 cases from 9 other spindle cell tumors were collected for STAT6 immunostaining. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000745DOI Listing
January 2019
2 Reads

Risk-stratified surveillance in dermatofibrosarcoma protuberans: Less is more.

Cancer 2019 Jan 15. Epub 2019 Jan 15.

Sarcoma Site Group, Princess Margaret Cancer Centre and Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/cncr.31922
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http://dx.doi.org/10.1002/cncr.31922DOI Listing
January 2019
5 Reads

Outcome after surgical treatment of dermatofibrosarcoma protuberans (DFSP): Is clinical follow-up always indicated?

Cancer 2019 Jan 15. Epub 2019 Jan 15.

Sarcoma Unit, Department of Surgery, Royal Marsden Hospital, London, United Kingdom.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma for which clinical examination up to 10 years is recommended. The objective of this study was to identify prognostic factors for recurrences and metastases that can be used to evaluate the validity of follow-up schedules after treatment for DFSP.

Methods: Patients with DFSP who received treatment between 1991 and 2016 at 3 tertiary centers were included. Read More

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http://doi.wiley.com/10.1002/cncr.31924
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http://dx.doi.org/10.1002/cncr.31924DOI Listing
January 2019
4 Reads

Preoperative 3-Dimensional Reconstruction of Dermatofibrosarcoma Protuberans.

Dermatol Surg 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology and Dermatologic Surgery, Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, China Department of Dermatology and Dermatologic Surgery Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, China.

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http://dx.doi.org/10.1097/DSS.0000000000001781DOI Listing
January 2019
6 Reads

Hypocellular medallion-like dermal dendrocyte hamartoma on the abdomen of a 25 year old male.

J Cutan Pathol 2019 Jan 11. Epub 2019 Jan 11.

Department of Dermatology, Philadelphia College of Osteopathic Medicine, Roswell, Georgia.

Medallion-like dermal dendrocyte hamartoma is a rare congenital lesion that is more commonly seen in females. It often presents at birth on the neck or upper trunk as a well-circumscribed, atrophic patch with wrinkling of the overlying skin. Clinically, the differential diagnosis includes atrophoderma, anetoderma, and congenital atrophic dermatofibrosarcoma protuberans. Read More

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http://dx.doi.org/10.1111/cup.13421DOI Listing
January 2019
5 Reads

Recurrent Dermatofibrosarcoma Protuberans of the Parotid: A case report and review of literature.

J Pak Med Assoc 2019 Jan;69(1):113-115

Aga Khan University Hospital, Karachi.

In 1924, Darier and Ferrand described Dermatofibrosarcoma Protuberans as a progressive and recurring dermatofibroma. It is a locally aggressive sarcoma originating from dermal and subdermal tissue of the skin. It usually begins as a small plaque that grows over a period and later manifests as multiple small subcutaneous nodules. Read More

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January 2019
2 Reads
0.403 Impact Factor

Fibroblastic and myofibroblastic tumors of children: new genetic entities and new ancillary testing.

Authors:
David M Parham

F1000Res 2018 20;7. Epub 2018 Dec 20.

Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Fibroblastic and myofibroblastic tumors comprise a morphologically diverse and biologically variable group of neoplasms that affect a wide age range. Specific entities tend to occur most frequently in infants and young children. Recent years have witnessed a proliferation of information concerning the unique biology of these tumors. Read More

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https://f1000research.com/articles/7-1963/v1
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http://dx.doi.org/10.12688/f1000research.16236.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305242PMC
December 2018
2 Reads

Imatinib Treatment for Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans: A Systematic Review.

JAMA Dermatol 2019 Jan 2. Epub 2019 Jan 2.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Dermatofibrosarcoma protuberans (DFSP) has the potential for local destruction and recurrence, although it carries a low risk of metastasis. Complete surgical resection with negative margins is considered the gold standard for treatment; however, there are cases that are unresectable owing to tumor extension or size or owing to risk of cosmetic and/or functional impairment. Imatinib treatment has been used for locally advanced or metastatic DFSP. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4940DOI Listing
January 2019

[Perianal dermatofibrosarcoma protuberans: a case report, review and update].

Rev Esp Patol 2019 Jan - Mar;52(1):62-68. Epub 2018 Apr 5.

UGC de Cirugía General y Aparato Digestivo, Complejo Hospitalario Torrecárdenas, Almería, España.

Dermatofibrosarcoma protuberans is a low-grade sarcoma typically originating in the dermis but with local invasion of subcutaneous cell and muscle tissue. We report a case of perianal dermatofibrosarcoma protuberans in a 41-year-old male complaining of anal pain and constipation. To date, only two cases of perianal dermatofibrosarcoma protuberans have been reported. Read More

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http://dx.doi.org/10.1016/j.patol.2018.02.004DOI Listing
April 2018
2 Reads

No, it is not a third breast that grows!

Pan Afr Med J 2018 16;30:213. Epub 2018 Jul 16.

General Practitioner Office Henri IV 45, Boulevard Henri IV, Ambert France.

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http://dx.doi.org/10.11604/pamj.2018.30.213.16402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294974PMC
January 2019

Reverse turnover pedicled latissimus dorsi muscle flap for lower back reconstruction: Two case reports.

Medicine (Baltimore) 2018 Dec;97(51):e13851

Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Rationale: Large soft tissue defects on the lower back represent a treatment challenge. Among a variety of reconstructive procedures, the latissimus dorsi (LD) muscle or musculocutaneous flap is one of most frequently used pedicled flaps. However, the pedicled LD flap carries a bulky pivot point and a short arc of rotation. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0013
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http://dx.doi.org/10.1097/MD.0000000000013851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320210PMC
December 2018
12 Reads

[Umbilical fibrous hamartoma of infancy: A case report].

Rev Chil Pediatr 2018 Oct;89(5):655-659

Servicio de Anatomía Patológica, Clínica Santa María, Santiago, Chile.

Introduction: Fibrous hamartoma of infancy (FHI) is a benign, soft tissue tumor that usually oc curs in children and has a characteristic histological morphology.

Objective: To describe a case of congenital FHI with atypical histological and clinical characteristics.

Clinical Case: Full-term male newborn, with no perinatal morbid history was referred to dermatology due to a congenital erythe matous plaque in the umbilical region. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000803DOI Listing
October 2018
10 Reads

A green-brown plaque on the dorsal hand.

JAAD Case Rep 2019 Jan 6;5(1):60-62. Epub 2018 Dec 6.

Department of Dermatology, University of California, Irvine, California.

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http://dx.doi.org/10.1016/j.jdcr.2018.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289953PMC
January 2019

Pediatric head and neck fibrosarcomas: A demographical, treatment, and survival analysis and review of a rare case.

Int J Pediatr Otorhinolaryngol 2019 Jan 2;116:92-96. Epub 2018 Oct 2.

University of Central Florida College of Medicine, Orlando, FL, USA; Division of Otolaryngology-Head Neck Surgery/Audiology, Nemours Children's Hospital, Orlando, FL, USA. Electronic address:

Objective: To examine pediatric head and neck fibrosarcoma cases and review the demographics, management, and survival for these patients.

Methods: Pediatric patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of a head and neck fibrosarcoma using ICD-O-3 head and neck primary sites and histology codes. Patients were included from birth-18 years of age. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.09.031DOI Listing
January 2019

Guidelines for Diagnosis and Treatment of Cutaneous Sarcomas: Dermatofibrosarcoma Protuberans.

Actas Dermosifiliogr 2018 Dec 4;109(10):868-877. Epub 2018 Jul 4.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Sarcomas comprise a broad group of tumors, many of whose biological behavior and aggressiveness differ from one type to another. The therapeutic approach is generally multidisciplinary and often complex. Developments in surgical and oncological dermatology during the last few decades have positioned dermatologists as specialists in the diagnosis and treatment of skin cancer. Read More

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http://dx.doi.org/10.1016/j.ad.2018.05.006DOI Listing
December 2018
3 Reads

Patterns of infiltration and local recurrences of various types of cutaneous sarcomas following three-dimensional histology.

J Dtsch Dermatol Ges 2018 Dec;16(12):1434-1442

Department of Dermatology, Eberhardt Karls University, Tübingen Germany.

Background: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13708
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http://dx.doi.org/10.1111/ddg.13708DOI Listing
December 2018
13 Reads

Cutaneous Sarcomas.

Hematol Oncol Clin North Am 2019 Feb;33(1):87-101

Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA; Cutaneous Oncology Program, Dana Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

Cutaneous sarcomas are rare malignancies that may present with a variety of clinical manifestations. This article focuses on 4 of the most common cutaneous sarcomas (Kaposi sarcoma, cutaneous angiosarcoma, dermatofibrosarcoma protuberans, and cutaneous leiomyosarcoma) and reviews clinical, diagnostic, and therapeutic aspects of these rare skin malignancies. Read More

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http://dx.doi.org/10.1016/j.hoc.2018.08.007DOI Listing
February 2019
1 Read

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

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http://dx.doi.org/10.1007/s12105-018-0988-1DOI Listing
November 2018
8 Reads

[Alternative therapy option for plastic-aesthetic treatment of defects after resection in the upper third of the facial region in the sense of subtotal scalping instead of local flap plastics].

Hautarzt 2019 Feb;70(2):123-126

Klinik für Mund‑, Kiefer- und Gesichtschirurgie, Universitätsklinikum Münster, Waldeyerstr. 30, 48149, Münster, Deutschland.

In the presented case, the resulting defect size after resection of a dermatofibrosarcoma protuberans exceeded the treatment capability with local flaps in the region of the exposed facial skin. Through the use of conventional wound healing in combination with a meshed split-thickness skin graft, plastic aesthetic soft tissue treatment with an aesthetically satisfactory result was possible. Read More

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http://dx.doi.org/10.1007/s00105-018-4308-1DOI Listing
February 2019
1 Read

Dermatofibrosarcoma Protuberans in a Male Infant.

Urology 2018 Nov 10. Epub 2018 Nov 10.

Department of Urology, University of Kentucky, Lexington, KY; Department of Surgery, Division of Urology, University of Colorado, Aurora, CO. Electronic address:

Dermtofibrosarcoma protuberans is a rare cutaneous malignancy known to be locally aggressive. It is uncommonly seen in the pediatric population and can be difficult to distinguish from other benign skin lesions. We present a case of dermatofibrosarcoma protuberans of the penis in a 6-month-old child managed with surgical resection. Read More

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http://dx.doi.org/10.1016/j.urology.2018.08.050DOI Listing
November 2018
7 Reads

Establishment of novel patient-derived models of dermatofibrosarcoma protuberans: two cell lines, NCC-DFSP1-C1 and NCC-DFSP2-C1.

In Vitro Cell Dev Biol Anim 2019 Jan 8;55(1):62-73. Epub 2018 Nov 8.

Department of Innovative Seeds Evaluation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Dermatofibrosarcoma protuberans (DFSP) is a common type of dermal sarcoma, characterized by the presence of the unique collagen type I alpha 1 chain (COL1A1)-PDGFB translocation, which causes constitutive activation of the platelet-derived growth factor β (PDGFB) signaling pathway. Patients with DFSP exhibit frequent local recurrence, and novel therapeutic approaches are required to achieve better clinical outcomes. Patient-derived cancer cell lines are essential in the preclinical research. Read More

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http://link.springer.com/10.1007/s11626-018-0305-z
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http://dx.doi.org/10.1007/s11626-018-0305-zDOI Listing
January 2019
11 Reads

Bednar Tumour Occurring after Malignant Melanoma Excision.

Case Rep Pathol 2018 1;2018:7694272. Epub 2018 Oct 1.

Anatomic Pathology, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.

We report the case of a seventy-four-year-old man with a slow-growing 2 cm mass on the back that arose near the surgical scar of previously excised melanoma, invasive to a Breslow depth of 3 mm. Preoperative clinical diagnosis was "in-transit" melanoma metastasis. After surgical excision, histopathologic examination revealed a dermal nodular proliferation of spindle cells arranged in storiform pattern, with mild pleomorphism, infiltrating around appendages and into the subcutaneous tissue. Read More

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https://www.hindawi.com/journals/cripa/2018/7694272/
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http://dx.doi.org/10.1155/2018/7694272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188857PMC
October 2018
11 Reads

Clinical and radiographic presentation of pelvic sarcoma in children.

SICOT J 2018 19;4:44. Epub 2018 Oct 19.

Department of Orthopaedics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Introduction: Pelvic sarcomas may present with vague symptoms. The aim of this study was to examine the characteristics and clinical presentations of different types of pelvic sarcoma in children.

Methods: This is a retrospective cohort study of patients up to 21 years of age with the diagnosis of pelvic sarcoma between January 2000 and June 2013. Read More

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http://dx.doi.org/10.1051/sicotj/2018040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195345PMC
October 2018
8 Reads

Expression of proton-sensing G-protein-coupled receptors in selected skin tumors.

Exp Dermatol 2019 Jan 13;28(1):66-71. Epub 2018 Dec 13.

Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.

Background: In humans, there are four known proton-sensing G-Protein-coupled receptors (pH-GPCRs): GPR4 (GPR19), TDAG8 (GPR65, T-cell death-associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1) and G2A (GPR132, G2 accumulation protein). They are known to be involved in sensing changes of extracellular proton concentrations in the acidic microenvironment of tumors, which leads to altered cell proliferation, migration, metastasis, immune cell function and inflammation. However, little is known about the expression of pH-GPCRs in the skin and especially skin cancers. Read More

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http://dx.doi.org/10.1111/exd.13809DOI Listing
January 2019
14 Reads

Jellyfish-like sonographic pattern can help recognition of dermatofibrosarcoma protuberans. Report of 3 new cases and review of the literature.

Australas J Dermatol 2018 Oct 14. Epub 2018 Oct 14.

Department of Dermatology, Hospital Universitario La Paz, Madrid, Spain.

High-frequency ultrasonography (HFUS) can help improve dermatofibrosarcoma protuberans (DFSP) recognition. We present three cases of DFSP in which a "jellyfish-like" sonographic pattern was a useful adjunct in formulating the diagnosis. In addition, we review all DFSP ultrasound images available in the literature. Read More

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http://doi.wiley.com/10.1111/ajd.12922
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http://dx.doi.org/10.1111/ajd.12922DOI Listing
October 2018
3 Reads

An audit of the diagnosis and reporting of soft tissue sarcomas at the Lagos University Teaching Hospital.

Niger J Clin Pract 2018 Oct;21(10):1330-1336

Department of Anatomic and Molecular Pathology, Lagos University Teaching Hospital, Lagos, Nigeria.

Background: : The effective management of patients with cancer is predicated on the right diagnoses and other relevant parameters included in the pathology report. This is particularly important in soft tissue pathology where arriving at the right diagnosis is often challenging. The aim of this study, therefore, was to perform an audit of sarcoma diagnosis and reporting in our institution. Read More

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http://dx.doi.org/10.4103/njcp.njcp_340_17DOI Listing
October 2018
1 Read

[Dermatofibrosarcoma: Management].

Bull Cancer 2018 Nov 5;105(11):1094-1101. Epub 2018 Oct 5.

Centre Oscar Lambret, département de cancérologie générale, 3, rue F. Combemale, 59020 Lille, France.

Dematofibrosarcoma protuberans (DFSP) are very rare (1 to 4 incident cases per million of inhabitants). The local spreading of DFSP is underestimated. The histological diagnosis is challenging but we now know a specific marker (translocation t(17;22)(q22;q13) (COL1A1;PDGFB)). Read More

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http://dx.doi.org/10.1016/j.bulcan.2018.08.008DOI Listing
November 2018
2 Reads

Dermatofibrosarcoma of The Breast - Case Report and Review of Literature.

Eur J Breast Health 2018 Oct 1;14(4):234-237. Epub 2018 Oct 1.

Department of Clinical Oncology and Nuclear Medicine, Sohag University Hospital, Sohag, Egypt.

Dermatofibrosarcoma protuberans is a rare form of soft tissue sarcoma that tends to invade and recur locally. The most common site of this disease is head, neck and extremities; however, the involvement of the breast has been reported. We present a case with a dermatofibrosarcoma of the breast that is composed of low-grade spindle cells which are positive for CD43. Read More

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http://www.eurjbreasthealth.com/eng/makale/638/56/Full-Text
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http://dx.doi.org/10.5152/ejbh.2018.3994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170017PMC
October 2018
2 Reads

Dermatofibrosarcoma Protuberans of the Breast-a Rare Entity.

Indian J Surg Oncol 2018 Sep 10;9(3):351-354. Epub 2017 Aug 10.

3Department Of Endocrine Surgery, Christian Medical College Vellore, Tamil Nadu, 632004 India.

Dermatofibrosarcoma protuberans (DFSP) represents about 1% of soft-tissue sarcomas with an estimated incidence of 0.8 to 5.0 cases per million per year. Read More

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http://dx.doi.org/10.1007/s13193-017-0684-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154368PMC
September 2018
5 Reads

Histopathological pattern of skin cancer in Western region of Saudi Arabia. An 11 years experience.

Saudi Med J 2018 Oct;39(10):994-998

Department of Pathology, Taibah University, Madinah, Kingdom of Saudi Arabia. E-mail.

Objectives: To determine the histopathological pattern of skin cancer in Madinah region of Kingdom of Saudi Arabia (KSA). Methods: This is a retrospective study including all cases with a histological diagnosis of skin cancer diagnosed at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia, between January 2006 and December 2017. Data included  age, gender, site and histology of the tumor were collected from histopathological reports and analyzed using Statistical Package for the Social Sciences  (SPSS) Version 21. Read More

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http://dx.doi.org/10.15537/smj.2018.10.22679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201021PMC
October 2018
7 Reads

First reported case of dermatofibrosarcoma in siblings.

Authors:
H Smith M Lam A Patel

Clin Exp Dermatol 2018 Sep 28. Epub 2018 Sep 28.

Dermatology Department, Gateway A, The Treatment Centre, Circle Nottingham, Lister Road, Nottingham, NG7 2FT, UK.

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http://doi.wiley.com/10.1111/ced.13788
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http://dx.doi.org/10.1111/ced.13788DOI Listing
September 2018
7 Reads

Pediatric dermatologic surgery: our experience.

G Ital Dermatol Venereol 2018 Sep 24. Epub 2018 Sep 24.

Department of Dermatology, ASST degli Spedali Civili, Spedali Civili di Brescia, Brescia, Italy.

Background: Surgical treatment for pediatric skin disorders are used for diagnostic and therapeutic reasons. We underline these procedures are usually easy and uncomplicated without the need for general anesthesia. Objective of this study was to share our experience in the field of pediatric dermatologic surgery. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.06140-0DOI Listing
September 2018
5 Reads

Metastasis of dermatofibrosarcoma diagnosed by capsule endoscopy.

Rev Esp Enferm Dig 2019 Jan;111(1):71-72

Aparato Digestivo, Hospital Clínico San Carlos.

In the study of obscure gastrointestinal bleeding, which includes iron-deficiency anemia, the capsule endoscopy is a valuable diagnostic tool. In the different series the presence of tumors reaches 16% as the cause of it. We present the case of a rare tumor with metastatic extension in the small intestine in which the capsule endoscopy was key to the diagnosis and survival of the patient. Read More

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http://dx.doi.org/10.17235/reed.2018.4900/2017DOI Listing
January 2019
12 Reads

Collagen Features of Dermatofibrosarcoma Protuberans Skin Base on Multiphoton Microscopy.

Technol Cancer Res Treat 2018 01;17:1533033818796775

1 College of Photonic and Electronic Engineering, Fujian Normal University, Fujian Provincial Key Laboratory of Photonic Technology, Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fuzhou, China.

Dermatofibrosarcoma protuberans is a rare, low-grade skin fibroblastic tumor which tends to recur locally due to its high misdiagnosis. Dermatofibrosarcoma protuberans usually spreads through the intracutaneous and subcutaneous layers into the deep dermis layer in which the main component is collagen. Therefore, alterations in collagen shape and content are important for accurate diagnosis of dermatofibrosarcoma protuberans. Read More

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http://dx.doi.org/10.1177/1533033818796775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137550PMC
January 2018
6 Reads

Recurrent Dermatofibrosarcoma with Pigmentation and Myoid Differentiation.

Sultan Qaboos Univ Med J 2018 May 9;18(2):e228-e230. Epub 2018 Sep 9.

Department of Surgery, Maulana Azad Medical College, New Delhi, India.

Dermatofibrosarcomas (DFSP) are rare low-grade tumours with various subtypes and usually occur among middle-aged adults. However, myoid differentiation is very rare. We report a 44-year-old woman who presented to the Lok Nayak Jai Prakash Hospital, New Delhi, India, in 2017 with a recurrent pigmented DFSP presenting as an arm swelling. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132508PMC
May 2018
3 Reads

Dermatofibrosarcoma Protuberans Secondary to a Decorative Tattoo: An Isotattootopic Response?

Indian J Dermatol 2018 Sep-Oct;63(5):439-440

Department of Surgery and Translational Medicine, Division of Dermatology and Venereology, University of Florence, Florence, Italy. E-mail:

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http://dx.doi.org/10.4103/ijd.IJD_265_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124234PMC
September 2018
3 Reads

Nodular fasciitis, a forgotten entity.

Int J Dermatol 2019 Feb 6;58(2):190-193. Epub 2018 Sep 6.

Department of Dermatology, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Background: Nodular fasciitis is a benign pseudosarcomatous, self-limited, and reactive process. Based on its clinical and histological features - a fast-growing, solitary tumor with high cellularity and mitotic count - nodular fasciitis is considered to be a benign mimic of sarcoma.

Methods: We present four cases of nodular fasciitis and a review of the literature. Read More

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http://doi.wiley.com/10.1111/ijd.14219
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http://dx.doi.org/10.1111/ijd.14219DOI Listing
February 2019
13 Reads

Novel KHDRBS1-NTRK3 rearrangement in a congenital pediatric CD34-positive skin tumor: a case report.

Virchows Arch 2019 Jan 6;474(1):111-115. Epub 2018 Sep 6.

Department of Dermatology, Unit of Pediatric Dermatology - CHRU Tours, Tours, France.

Cutaneous spindle-cell neoplasms in adults as well as children represent a frequent dilemma for pathologists. Along this neoplasm spectrum, the differential diagnosis with CD34-positive proliferations can be challenging, particularly concerning neoplasms of fibrohistiocytic and fibroblastic lineages. In children, cutaneous and superficial soft-tissue neoplasms with CD34-positive spindle cells are associated with benign to intermediate malignancy potential and include lipofibromatosis, plaque-like CD34-positive dermal fibroma, fibroblastic connective tissue nevus, and congenital dermatofibrosarcoma protuberans. Read More

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http://dx.doi.org/10.1007/s00428-018-2415-0DOI Listing
January 2019
14 Reads
2.651 Impact Factor

A novel case of an aggressive superficial spindle cell sarcoma in an adult resembling fibrosarcomatous dermatofibrosarcoma protuberans and harboring an EML4-NTRK3 fusion.

J Cutan Pathol 2018 Dec 26;45(12):933-939. Epub 2018 Sep 26.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.

A subset of soft tissue sarcomas often harbors recurrent fusions involving protein kinases. While some of these fusion events have shown utility in arriving at a precise diagnosis, novel fusions in otherwise difficult to classify sarcomas continue to be identified. We present a case of a 40-year-old female who noted a lower back nodule in 2010 that was initially labeled as a dermatofibrosarcoma protuberans with fibrosarcomatous transformation. Read More

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http://doi.wiley.com/10.1111/cup.13348
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http://dx.doi.org/10.1111/cup.13348DOI Listing
December 2018
5 Reads

Recurrent dermatofibrosarcoma protuberans: challenging a surgeon's dexterity for the 'tricky' margins.

Ecancermedicalscience 2018 13;12:858. Epub 2018 Aug 13.

Department of General Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110 029, India.

Soft tissue tumours represent 0.2%-1% of all breast malignancies. [Al Tarakji M, Toro A, and Di Carlo I, (2015) 158 https://doi. Read More

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http://dx.doi.org/10.3332/ecancer.2018.858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113985PMC
August 2018
1 Read

Review of the medical literature and assessment of current utilization patterns regarding the use of two common fluorescence in situ hybridization assays in the diagnosis of dermatofibrosarcoma protuberans and clear cell sarcoma.

J Cutan Pathol 2018 Dec 27;45(12):905-913. Epub 2018 Sep 27.

Departments of Dermatology and Pathology, University of Michigan Medical Center, Ann Arbor, Michigan.

Background: Dermatofibrosarcoma protuberans (DFSP) is a tumor of intermediate malignancy, which in selected circumstances can pose difficulty in diagnosis. Clear cell sarcoma (CCS) is a very rare aggressive soft tissue sarcoma that can be difficult to distinguish histologically from melanoma.

Methods: The current literature on t(17;22) COL1A1-PDGFB fluorescence in situ hybridization (FISH) assay in DFSP was reviewed. Read More

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http://doi.wiley.com/10.1111/cup.13345
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http://dx.doi.org/10.1111/cup.13345DOI Listing
December 2018
14 Reads