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    1847 results match your criteria Dermatofibrosarcoma Protuberans

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    Acral dermatofibrosarcoma protuberans with myoid differentiation: a report of two cases.
    J Cutan Pathol 2017 Jun 19. Epub 2017 Jun 19.
    Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, BO Box 3354 MBC#10, Riyadh, 11211, Saudi Arabia.
    Dermatofibrosarcoma protuberans (DFSP) is a low-grade mesenchymal neoplasm with a tendency for local recurrence; it is rarely metastatic. Dermatofibrosarcoma protuberans typically arises in the trunk and proximal extremities. However, it can arise in unusual sites such as the hands and feet. Read More

    "Congenital dermatofibrosarcoma protuberans clinically mimicking a melanocytic nevus treated with serial excisions".
    J Eur Acad Dermatol Venereol 2017 Jun 16. Epub 2017 Jun 16.
    Universitätsklinikum Dresden, Klinik für Dermatologie, Dresden, Deutschland.
    A 9-year-old female patient was referred to our department with the clinical diagnosis of a congenital melanocytic nevus on the back for serial excisions. The child's parents confirmed that the lesion existed since birth. Only little changes in color and size were observed over the years. Read More

    Phosphohistone-H3 and Ki67: Useful Markers in Differentiating Dermatofibroma From Dermatofibrosarcoma Protuberans and Atypical Fibrohistiocytic Lesions.
    Am J Dermatopathol 2017 Jul;39(7):504-507
    *Department of Pathology, Baylor University Medical Center, Dallas, TX; †Department of Pathology, Pathologist Biomedical Laboratories, Dallas, TX; ‡Department of Pathology, UF Health, Jacksonville, Jacksonville, FL; §Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX; and ¶Department of Pathology, MD Anderson Cancer Center, Houston, TX.
    Dermatofibromas (DF) are common, benign, skin tumors, usually easily differentiated from dermatofibrosarcoma protuberans (DFSP) by the presence of a relative low cellularity, lesser degree of infiltration of subcutaneous tissue, and immunohistochemical pattern (eg, FXIIIa in DF and CD34 in DFSP). Atypical fibrohistiocytic lesions (AFL) have features intermediate to DF and DFSP (trunk location, storiform pattern, infiltration of the subcutaneous tissue, and focal expression of both CD34 and Factor XIIIa). It is unclear if mitotic counts/degree of proliferation is helpful to distinguish DF from DFSP. Read More

    Recurrence case of rare scalp dermatofibrosarcoma protuberans: Two case reports of a wide radical excision, craniectomy bone involvement followed by cranioplasty and reconstruction.
    Surg Neurol Int 2017 26;8:82. Epub 2017 May 26.
    Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade sarcoma of the fibroblast originating from the dermal layer of the skin, characterized by a locally aggressive growth and high rate of local recurrence.

    Case Description: Two patients underwent a wide radical excision of recurrent scalp DFSP which was reconstructed with translational skin flap and split-thickness skin graft. We described above cases several years ago with a local excision of the tumor; recently, they developed local recurrence of DFSP with calvarial involvement. Read More

    Clinical Features, Pathological Findings and Treatment of Recurrent Dermatofibrosarcoma Protuberans.
    J Cancer 2017 12;8(7):1319-1323. Epub 2017 May 12.
    Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
    Dermatofibrosarcoma protuberans (DESP) is a relatively rare and low-grade tumor of the skin and soft tissue. We review the clinical features, pathological findings and management of recurrent DESP with the aim to improve our understanding of this rare tumor. Fifty-seven patients were diagnosed with recurrent DFSP. Read More

    Massively Metastatic Dermatofibrosarcoma Protuberans With Fibrosarcomatous Transformation Years After Surgical Resection.
    Dermatol Surg 2017 Jun 6. Epub 2017 Jun 6.
    Department of Dermatology, Stanford University School of Medicine, Redwood City, CaliforniaDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CaliforniaDepartment of Pathology, Cedars-Sinai Medical Center, Los Angeles, CaliforniaDepartment of Dermatology, Kaiser Permanente Los Angeles, Los Angeles, California.

    Cutaneous sarcomas.
    J Dtsch Dermatol Ges 2017 Jun;15(6):630-648
    Department of Dermatology and Allergology, Munich Technical University, Munich, Germany.
    Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include atypical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life. Read More

    Kutane Sarkome.
    J Dtsch Dermatol Ges 2017 Jun;15(6):630-649
    Klinik und Poliklinik für Dermatologie und Allergologie, Technische Universität München.
    Cutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best-known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include a typical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and angiosarcoma. With the exception of dermatofibrosarcoma protuberans, which has its peak incidence in middle-aged adults, cutaneous sarcomas usually occur in elderly individuals starting in the sixth or seventh decade of life. Read More

    Dermatofibrosarcoma Protuberans in a 9-Year-Old Child.
    Indian Dermatol Online J 2017 May-Jun;8(3):195-197
    Department of Dermatology, Topiwala National Medical College and B.Y.L. Nair Hospital, Mumbai, Maharashtra, India.
    Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue neoplasm of low-to-intermediate grade malignant potential. Childhood onset of DFSP is rare. It is most commonly seen on the trunk and proximal extremities. Read More

    Wide local excision vs Mohs Tübingen technique in the treatment of Dermatofibrosarcoma Protuberans: A two- centre retrospective study and literature review.
    J Eur Acad Dermatol Venereol 2017 Jun 2. Epub 2017 Jun 2.
    Dept. Of Health Science and Dept of Translational Medicine.
    Background: Dermatofibrosarcoma Protuberans is a rare, low-grade mesenchymal skin tumour, characterized by slow infiltrative growth and common local recurrence, with infrequent distant metastases.

    Objective: The aim of this study is to better clarify clinico-pathological characteristics of this tumour and to evaluate the cure rates of Mohs Tübingen technique (MTT) and wide local excision. Eventually, we perform a literature review to compare our experience with published data. Read More

    Extragastrointestinal stromal tumor of the abdominal subcutaneous tissue: Report of a very rare case at an unusual site.
    J Int Med Res 2017 Jun 28;45(3):1273-1278. Epub 2017 May 28.
    Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
    Extragastrointestinal stromal tumors (EGISTs) are rare tumors that arise outside the digestive tract. We report a case of an EGIST arising in the subcutaneous tissue of the abdominal wall, which at this site can often be misdiagnosed as dermatofibrosarcoma protuberans. The tumor was surgically resected from a 72-year-old male Chinese Han patient, and pathological examination revealed spindle-shaped tumor cells with eosinophilic cytoplasm and an oval nucleus. Read More

    The Immunological Roles of Periostin/Tumor-Associated Macrophage Axis in Development of Dermatofibrosarcoma Protuberans.
    Anticancer Res 2017 06;37(6):2867-2873
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Background/aim: Dermatofibrosarcoma protuberance (DFSP) is a fibrohistiocytic tumor of intermediate malignancy characterized by slow infiltrative growth and a high tendency to recur locally. Periostin is involved in modulating cell function and inducing the production of proinflammatory cytokines, chemokines, and matrix metalloproteinases (MMPs) from tumor-associated macrophages (TAMs) to promote fibrosis and tumor growth. This study aimed to examine the cancer stroma of DFSP, focusing on TAMs-related proteins and MMPs. Read More

    Diagnosis and Management of Dermatofibrosarcoma Protuberans in a 3-Year-Old Patient.
    J Hand Surg Am 2017 May 24. Epub 2017 May 24.
    Division of Plastic Surgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI. Electronic address:
    In this case report, we present a 3-year-old boy with a diagnosis of dermatofibrosarcoma protuberans (DFSP) on the dorsum of his right hand. Although rarely metastatic, DFSP is highly locally invasive and can cause considerable local morbidity. In the hand, DFSP is uncommon in the young pediatric patient. Read More

    Dermatofibrosarcoma Protruberans of the Breast Skin Simulating Mammary Carcinoma.
    Indian J Surg Oncol 2017 Jun 22;8(2):198-202. Epub 2016 Nov 22.
    Department of Pathology, Bhopal Memorial Hospital and Research Centre, Raisen Bypass Road, Bhopal, 462038 India.
    Dermatofibrosarcoma protuberans is a rare soft tissue sarcoma that arises from the dermis and invades deeper tissues. Usually, it behaves as an intermediate grade malignancy but in rare instances, it can metastasize. Frequent occurrences have been observed in trunk and extremities but involvement of the breast has rarely been reported. Read More

    Metastasis of soft tissue sarcomas in lymph node. A cytomorphological study.
    Diagn Cytopathol 2017 May 24. Epub 2017 May 24.
    Department of Pathology, Gujarat Cancer And Research Institute (GCRI), Ahmedabad, Gujarat, India.
    Background: Soft-tissue sarcoma (STS) rarely metastasizes to lymph node compared to carcinoma. Fine-needle aspiration cytology (FNAC) carries a pivotal role in diagnosis of metastatic tumor to lymph node. This study highlights the role of FNAC in diagnosis of STS metastasis to lymph node. Read More

    The management of soft tissue tumours of the abdominal wall.
    Eur J Surg Oncol 2017 May 6. Epub 2017 May 6.
    The Sarcoma Unit, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom. Electronic address:
    Background: Soft tissue tumours of the abdominal wall account for approximately 10% of all soft tissue tumours. Tumours at this site comprise a heterogeneous group of pathologies with distinct clinical behaviours and responses to treatment. The management of these tumours has largely been extrapolated from studies of soft tissue tumours at other sites. Read More

    Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans.
    Mol Clin Oncol 2017 May 17;6(5):665-668. Epub 2017 Mar 17.
    Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
    Dermatofibrosarcoma protuberans (DFSP) is a locally invading tumor, characterized by the presence of the collagen type I α 1 (COL1A1)-platelet-derived growth factor (PDGF) β fusion gene. We herein report the case of a 31-year-old man with a history of resection of an abdominal wall DFSP. The patient presented with chest pain and a computed tomography scan revealed a large mass in the posterior mediastinum and another mass in the right lung. Read More

    Dermatofibrosarcoma protuberans: when the age makes the difference.
    G Ital Dermatol Venereol 2017 May 16. Epub 2017 May 16.
    Dermatological Clinic, La Sapienza- Università di Roma, Rome, Italy.
    Background: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low- grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients. Read More

    Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas.
    Radiographics 2017 May-Jun;37(3):797-812
    From the Department of Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (A.D.L., M.A.M.); the American Institute for Radiologic Pathology, Silver Spring, Md (M.A.M.); and the Center of Cancer Research, National Cancer Institute, Bethesda, Md (M.M.M.).
    Soft-tissue sarcomas occurring in the abdomen and pelvis are an uncommon but important group of malignancies. Recent changes to the World Health Organization classification of soft-tissue tumors include the movement of gastrointestinal stromal tumors (GISTs) into the soft-tissue tumor classification. GIST is the most common intraperitoneal sarcoma. Read More

    A Review of the Global Guidelines on Surgical Margins for Nonmelanoma Skin Cancers.
    J Clin Aesthet Dermatol 2017 Apr;10(4):37-46
    Ohio State University Wexner Medical Center, Columbus, Ohio.
    Background: Adequate treatment and follow-up of a patient with nonmelanoma skin cancer is of utmost concern for a clinician. However, there is a lack of international consensus on recommendations for surgical excision margins. Furthermore, lack of familiarity of the published guidelines leads to a variety in practice styles. Read More

    Dermatofibrosarcoma Protuberance of the Breast: a Diagnostic Challenge.
    Indian J Surg 2017 Apr 16;79(2):169-172. Epub 2016 May 16.
    Department of Pathology, Hospital Tuanku Jaafar, Jalan Rasah, Seremban, 70300 Malaysia.
    Dermatofibrosarcoma protuberans (DFSP) is an uncommon slow growing neoplasm of the dermis with tendency to invade the subcutaneous tissues. It presents during the third to fourth decade of life and is commonly seen over the trunk, extremities and head and neck. DFSP presenting as a breast lump is rare but few cases have been reported in the literature. Read More

    [A tumour mistaken for a scar].
    Ned Tijdschr Geneeskd 2017 ;161(0):D707
    Amphia Ziekenhuis, afd. Dermatologie, Breda.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a rare type of cutaneous soft tissue sarcoma. The tumour metastasises rarely, but the percentage of recurrences is high and the tumour can be locally very aggressive.

    Case Description: A 50-year-old man was referred to our clinic for a long existing scar on his back, which had become painful in the last few weeks. Read More

    Subcutaneous dermatofibrosarcoma protuberans, a rare subtype with predilection for the head: A retrospective series of 18 cases.
    J Am Acad Dermatol 2017 Apr 15. Epub 2017 Apr 15.
    Dermatology Department, Instituto Valenciano de Oncologia, Valencia, Spain.
    Background: Dermatofibrosarcoma protuberans (DFSP) typically affects the dermis and subcutaneous tissue. The subcutaneous variant is rare.

    Objective: We sought to characterize the subcutaneous DFSP (SC-DFSP) variant and compare it with cutaneous DFSP (C-DFSP). Read More

    Non-melanoma skin cancer: new and future synthetic drug treatments.
    Expert Opin Pharmacother 2017 May 17;18(7):689-699. Epub 2017 Apr 17.
    a Center for Dermatooncology, Department of Dermatology , University Hospital Tübingen , Tübingen , Germany.
    Introduction: Non-melanoma skin cancers (NMSC) mainly comprise two different entities: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC); beneath these two entities, Merkel cell carcinoma, adnexal tumors, dermatofibrosarcoma protuberans, angiosarcoma, and cutaneous lymphoma belong to NMSC. These rare skin tumors are not the topic of this review. BCC and SCC are the most common cancers diagnosed in humans. Read More

    Breast and pleuropulmonary metastasis of multirecurrent scalp dermatofibrosarcoma protuberans: a case report.
    J Med Case Rep 2017 Apr 8;11(1):96. Epub 2017 Apr 8.
    Unité de Recherche en Sciences de la Santé, Université Ouaga I Professeur Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
    Background: Dermatofibrosarcoma protuberans is a rare tumor, representing about 0.1% of skin malignant tumors. It is characterized by local aggressiveness with significant potential for recurrence. Read More

    Long-term results of treatment of advanced dermatofibrosarcoma protuberans (DFSP) with imatinib mesylate - The impact of fibrosarcomatous transformation.
    Eur J Surg Oncol 2017 Jun 22;43(6):1134-1141. Epub 2017 Mar 22.
    Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center, Institute of Oncology, Warsaw Poland.
    Background: Dermatofibrosarcoma protuberans (DFSP) is rare, infiltrating dermal neoplasm, characterized by indolent growth and low probability of metastases. The first effective systemic therapy in DFSP introduced into clinical practice was imatinib, demonstrating high activity in advanced cases. The aim of the study was to perform an analysis of patients with advanced DFSP treated with imatinib, with or without surgery, in routine clinical practice with long-term follow-up. Read More

    Dermatofibrosarcoma Protuberans: An Immunomarker Study of 57 Cases That Included Putative Mesenchymal Stem Cell Markers.
    Appl Immunohistochem Mol Morphol 2017 Mar 30. Epub 2017 Mar 30.
    *Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center †VHS Medical Center, Seoul, Korea.
    Dermatofibrosarcoma protuberans (DFSP) is a low-grade fibroblastic sarcoma with a superficial location that has been suggested to potentially be a type of mesenchymal stem cell tumor. We studied the expression of various immunomarkers, including putative stem cell markers, in a series of 57 DFSPs including variants, and 12 dermatofibromas (DFs). CD105, a mesenchymal stem cell marker, was weakly expressed in 24 DFSPs, whereas other stem cell markers, including CD133, ALK-1, and Oct3/4, were completely negative in all samples. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: When is imaging necessary?
    J Am Acad Dermatol 2017 Apr;76(4):591-607
    Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.
    When treating aggressive skin cancers, pre- and postoperative imaging provides important information for treatment planning and multidisciplinary cooperation of care. It is important for dermatologists to recognize the clinical scenarios where imaging is indicated in the management of skin cancer. We here address the most common indications for imaging in cutaneous oncology and how to best utilize the modalities available. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: Diagnostic modalities and applications.
    J Am Acad Dermatol 2017 Apr;76(4):579-588
    Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:
    While uncomplicated cases of nonmelanoma skin cancer can be treated with surgery, destruction, or topical therapy alone, advanced or neglected cases require more complex management decisions. Dermatologists and dermatologic surgeons should be familiar with the imaging techniques relevant to cutaneous oncology and their value in different clinical scenarios. Herein we review imaging modalities used in management of nonmelanoma skin cancer. Read More

    Clinical Features and Treatment of Dermatofibrosarcoma Protuberans Affecting the Vulva: A Literature Review.
    Dermatol Surg 2017 Jun;43(6):771-774
    *Department of Medicine, Division of Dermatology, Creighton University School of Medicine, Omaha, Nebraska; †Department of Biology, Loyola Marymount University, Los Angeles, California.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a low-to-intermediate grade cutaneous neoplasm with a low propensity for metastasis and a high rate of local recurrence. It typically presents as a dermal plaque or nodule on the trunk, limbs, or head and neck region. Vulvar DFSP has also been described, although it is less common. Read More

    Perspectives on Low-grade Sarcomas: The Extraordinary Contributions of Sharon W. Weiss, MD.
    Adv Anat Pathol 2017 Jul;24(4):195-200
    *Department of Pathology, MetroHealth Medical Center/Case Western Reserve University †Department of Pathology, Cleveland Clinic, Cleveland, OH.
    Soft-tissue pathology encompasses a wide spectrum of neoplasms that represent some of the most challenging and problematic tumors in surgical pathology. Owing to the intensive work of dedicated pathologists, this once esoteric field has become increasingly well defined. In this review, Dr Sharon Weiss' monumental contributions to low-grade sarcomas, including low-grade fibromyxoid sarcoma/so-called hyalinizing spindle cell tumor, atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma, epithelioid hemangioendothelioma, and dermatofibrosarcoma protuberans with fibrosarcomatous transformation will be discussed. Read More

    Differential diagnosis of acute miliary pulmonary tuberculosis from widespread-metastatic cancer for postoperative lung cancer patients: two cases.
    J Thorac Dis 2017 Feb;9(2):E115-E120
    Department of Thoracic Oncology, Cancer Center, West China Hospital, Medical School, Sichuan University, Chengdu 610041, China; State Key Laboratory of Biotherapy, West China Hospital, Medical School, Sichuan University, Chengdu 610041, China.
    Pulmonary infections and lung cancer can resemble each other on radiographic images, which makes it difficult to diagnosis accurately and apply an appropriate therapy. Here we report two cases that two postoperative patients with lung adenocarcinoma developed diffuse nodules in bilateral lungs in a month which needed to be distinguished between metastatic malignancies and infectious diseases. Although there are much similarities in disease characteristics of two cases, patient in case one was diagnosed as acute miliary pulmonary tuberculosis (TB) while patient in case two was diagnosed as metastatic disease. Read More

    Application of COL1A1-PDGFB fusion gene detection by fluorescence in situ hybridization in biopsy tissue of dermatofibrosarcoma protuberans.
    J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
    Several uncommon variants of dermatofibrosarcoma protuberans (DFSP) and the limitations of small biopsies render pathological diagnosis difficult. The aim of this study was to analyze the utility of fluorescence in situ hybridization (FISH) in the detection of the collagen type I-α1/platelet derived growth factor-β (COL1A1-PDGFB) fusion gene in biopsies of DFSP. Twenty-three consecutive biopsy specimens of DFSP were reviewed for clinicopathological features and examined with the COL1A1-PDGFB fusion probe and PDGFB break-apart probe using FISH analysis. Read More

    Association of patient demographic characteristics with Dermatofibrosarcoma Protuberans tumor size at diagnosis in the National Cancer Data Base.
    Br J Dermatol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Dermatology, University of Arizona College of Medicine, Phoenix, AZ.
    Dermatofibrosarcoma protuberans (DFSP) is a rare, infiltrative but low-grade cutaneous tumor. Middle-aged and younger adults, males, and African-Americans are more likely to be affected by this malignancy, with up to 5 cases per million reported annually in the US. Despite its low metastatic potential and excellent survival, DFSP is prone to recurrence and can be very locally destructive. Read More

    Sclerosing Dermatofibrosarcoma Protuberans Shows Significant Overlap With Sclerotic Fibroma in Both Routine and Immunohistochemical Analysis: A Potential Diagnostic Pitfall.
    Am J Dermatopathol 2017 Feb;39(2):83-88
    Departments of *Dermatology, and †Pathology, University of California San Francisco, San Francisco, CA.
    Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-to-intermediate grade sarcoma with several histologic variants, including pigmented (Bednar tumor), sclerosing, myxoid, atrophic, and DFSP with fibrosarcomatous changes. Two patterns of sclerosis in DFSP can be observed, a sclerotic fibroma-like pattern and a morphea/lichen sclerosus-like pattern. Partial biopsies of sclerosing DFSPs with the sclerotic fibroma pattern can be misdiagnosed as sclerotic fibroma or other benign sclerosing tumors (eg, perineurioma, dermatofibroma). Read More

    Imatinib in Dermatofibrosarcoma: Targeted Therapy or Immunotherapy?
    J Invest Dermatol 2017 Feb;137(2):277-279
    Department of Dermatology, University of Duisburg-Essen, Essen, Germany; Translational Skin Cancer Research, German Cancer Consortium, West German Cancer Center, Essen, Germany. Electronic address:
    There is increasing evidence that certain kinase inhibitors are able to foster two strategies, i.e. inhibition of oncogenic activated molecular pathways and modulation of immunological processes. Read More

    Unusual Signal Patterns of Break-apart FISH Probes Used in the Diagnosis of Soft Tissue Sarcomas.
    Pathol Oncol Res 2017 Jan 20. Epub 2017 Jan 20.
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary.
    Break-apart FISH probes are the most popular and reliable type of FISH probes used to confirm certain pathological diagnoses. The interpretation is usually easy, however, in some instances it is not so unequivocal. Our aim was to reveal and elucidate the problems occurring in the process of evaluation of the break-apart probe results. Read More

    A single-institutional review of 68 patients with dermatofibrosarcoma protuberans: wide re-excision after inadequate previous surgery results in a high rate of local control.
    World J Surg Oncol 2017 Jan 5;15(1). Epub 2017 Jan 5.
    Department of Plastic Surgery, Burn Centre, Hand Centre, BG-University Hospital Bergmannsheil, Buerkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
    Background: Dermatofibrosarcoma protuberans (DFSP) is a cutaneous soft tissue sarcoma characterized by an indolent but aggressive local growth. Unplanned excisions with positive margins are common, and the prognostic impact of radical re-excisions is still unclear. The aim of the present study was to identify prognostic indicators of recurrence-free survival (RFS) in patients with DFSP through a long-term follow-up. Read More

    Superficial Acral Fibromyxoma: Report of 13 Cases With New Immunohistochemical Findings.
    Am J Dermatopathol 2017 Jan;39(1):14-22
    *Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; †Department of Pathology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain; and ‡Dermatopathology Laboratory, Friedrichschafen, Germany.
    Background: Superficial acral fibromyxoma (SAF) is a benign, soft tissue neoplasm preferably located on the digits.

    Methods: We collected 13 cases of SAF and evaluated their clinical, histopathologic, and immunohistochemical features.

    Results: This study included 9 males and 4 females, median age 54 years. Read More

    Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
    Dermatol Surg 2017 Jan;43(1):116-124
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

    Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

    Nodular Fasciitis Complicating a Staged Surgical Excision of Dermatofibrosarcoma Protuberans.
    Case Rep Dermatol Med 2016 27;2016:6074182. Epub 2016 Nov 27.
    Department of Dermatology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
    Dermatofibrosarcoma protuberans (DFSP) is an unusual spindle cell tumor with a high rate of local recurrence with traditional excision. Fortunately, Mohs micrographic surgery yields excellent cure rates for this neoplasm due to contiguous tumor spread and meticulous tumor mapping and margin analysis. We present the unique case of a patient treated with a modified Mohs technique with an analysis of the final margin with permanent sections, who developed a spindle cell neoplasm in the margins of her second stage excision consistent with nodular fasciitis. Read More

    Dermatofibroma of the eyelid with monster cells.
    Surv Ophthalmol 2017 Jul - Aug;62(4):533-540. Epub 2016 Dec 22.
    Department of Dermatology, Massachusetts General Hospital.
    Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A recurrent lesion of the right lower eyelid developed in a 64-year-old woman. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted, and hyperchromatic nucleus. Read More

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