2,240 results match your criteria Dermatofibrosarcoma Protuberans


The role of radiation therapy in the management of cutaneous malignancies. Part II: When is radiation therapy indicated?

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Departments of Dermatology and Head and Neck Surgery, The University of Texas MD Anderson Cancer, Houston, Texas, USA.

Radiation therapy may be performed for a variety of cutaneous malignancies depending on patient health status, tumor clinical and histologic features, patient preference, and resource availability. Dermatologists should be able to recognize the clinical scenarios in which radiation therapy is appropriate as this may reduce morbidity, decrease risk of disease recurrence, and improve quality of life. The second article in this 2-part continuing medical education series focuses on the most common indications for radiation therapy in the treatment of basal cell carcinoma, cutaneous squamous cell carcinoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi sarcoma, angiosarcoma, cutaneous lymphoma, melanoma, undifferentiated pleomorphic sarcoma, and sebaceous carcinoma. Read More

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Forehead and Frontal Scalp Reconstruction After Resection of Subcutaneous Dermatofibrosarcoma Protuberans.

Dermatol Surg 2021 Jun 9. Epub 2021 Jun 9.

All authors are affiliated with the Department of Dermatology, University Clinic of Navarra, Pamplona, Spain.

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Dermatofibrosarcoma protuberans in a child, that's why soft tissue lesions are not always innocent in children.

Clin Case Rep 2021 May 4;9(5):e04080. Epub 2021 Apr 4.

Department of Radiology Alexandroupolis University Hospital Democritus University of Thrace Alexandroupolis Greece.

Pediatric soft tissue tumors should be always operated and sent for a biopsy. Read More

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Dermatofibrosarcoma protuberans in atypical inguinal location: Diagnosis, treatment and follow-up scheme.

Arch Esp Urol 2021 Jun;74(5):532-535

Servicio de Urología. Hospital Universitario de Getafe. Getafe. Madrid. España.

Objective: To review dermatofibrosarcoma protuberans (DFSP), which is a soft tissue neoplasm of the skin that can rarely affect the genitals.

Material And Method: We report a case of inguinal DFSP in a 40-year-old male who presented a slow-growing mass adjacent to the spermatic cord.

Results: After extensive surgical resection pathological analysis confirmed the diagnosis of DFSP with resection margins affected, so reoperation with margin exeresis and inguinal orchiectomy was required. Read More

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Long-Term Outcome of Neoadjuvant Tyrosine Kinase Inhibitors Followed by Complete Surgery in Locally Advanced Dermatofibrosarcoma Protuberans.

Cancers (Basel) 2021 May 6;13(9). Epub 2021 May 6.

Department of Dermatology, AP-HP Saint-Louis Hospital, F-75010 Paris, France.

In locally advanced dermatofibrosarcoma protuberans (DFSP), imatinib mesylate has been described as an efficient neoadjuvant therapy. This retrospective study included patients with locally advanced DFSP who received neoadjuvant TKI (imatinib or pazopanib) from 2007 to 2017 at Saint Louis Hospital, Paris. The primary endpoint was the evaluation of the long-term status. Read More

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Raman spectroscopy based diagnosis of dermatofibrosarcoma protuberans: Case report.

Photodiagnosis Photodyn Ther 2021 May 25:102351. Epub 2021 May 25.

Department of Laser and Biotechnical Systems, Samara University, Samara, Russia. Electronic address:

Dermatofibrosarcoma protuberans is a rare disease and the rare occurrence of this pathology provokes insufficient oncological alertness among clinicians. A possible way to increase the accuracy of early diagnosis of rare skin neoplasms is "optical biopsy" using Raman spectroscopy tissue response. This case report of a 32-year-old woman with a dermatofibrosarcoma protuberans demonstrates that Raman spectroscopy based "optical biopsy" can help to diagnose rare tumors. Read More

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Virtual Multidisciplinary Review of a Complex Case Using a Digital Clinical Decision Support Tool to Improve Workflow Efficiency.

J Multidiscip Healthc 2021 20;14:1149-1158. Epub 2021 May 20.

Roche Diagnostics Asia Pacific, Ltd, Singapore.

Objective: Integration of distinct clinical perspectives in multi-disciplinary tumor board meetings is critical to determine optimal patient care. Digital tools can support the data consolidation needed for meeting preparation and data sharing during complex case reviews. In this paper, we assessed the value of a clinical decision support tool on workflow efficiency and conducting a complex case review of a dermatofibrosarcoma protuberans (DFSP) tumor. Read More

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Optical diagnosis of dermatofibrosarcoma protuberans differentiated from dermatofibroma using non-linear optical microscopy.

Chin Med J (Engl) 2021 May 19. Epub 2021 May 19.

Department of Dermatology, Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, China Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, Fujian 350007, China Department of Pathology, Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, China.

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A 28-year single institution experience with primary skin malignancies in the pediatric population.

J Plast Surg Hand Surg 2021 May 25:1-5. Epub 2021 May 25.

Division of Plastic Surgery, Mayo Clinic, Rochester, MN, USA.

The aim of this study is to report our institution's experience with pediatric skin malignancies. A single institution retrospective review of pediatric patients with a primary skin malignancy from 1992 to 2020 was performed. Demographics, tumor characteristics and treatment outcomes were reviewed. Read More

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Management of dermatofibrosarcoma protuberans.

Curr Opin Otolaryngol Head Neck Surg 2021 May 14. Epub 2021 May 14.

Department of Otolaryngology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Purpose: Provide an up to date review of the diagnosis, workup and treatment of dermatofibrosarcoma protuberans (DFSP). DFSP can be a challenging disease to manage and adequate understanding of the most up to date literature can help provide comprehensive treatment strategies.

Recent Findings: DFSP is an infiltrative cutaneous sarcoma. Read More

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Case report: Dermatofibrosarcoma of the breast.

Radiol Case Rep 2021 Jun 18;16(6):1524-1529. Epub 2021 Apr 18.

Medical Imaging Department, King Hamad University Hospital, Busaiteen, Kingdom of Baharin.

Dermatofibrosarcoma protuberans (DFSP) is an uncommon neoplasm of the skin and soft tissue, commonly appearing on the trunk and extremities. The occurrence of DFSP in the breast is extremely rare. It has low to intermediate malignant potential with a high rate of local recurrence and invasion. Read More

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Multicentric dermatofibrosarcoma protuberans in a child with severe combined immunodeficiency due to adenosine deaminase deficiency.

Pediatr Dermatol 2021 Apr 30. Epub 2021 Apr 30.

Departments of Paediatrics, Catholic Children´s Hospital Wilhelmstift, Hamburg, Germany.

We report the case of a 4-year-old boy, post-human stem cell transplantation for severe combined immunodeficiency (SCID) due to adenosine deaminase deficiency (ADA), who developed multiple dermatofibrosarcoma protuberans (DFSP). We hypothesize a role for chimerism leading to accumulation of toxic metabolites which can cause DNA strand breaks and inhibit lymphocyte activation. Patients with ADA-SCID should remain under lifelong dermatologic surveillance as DFSP lesions can be quite inconspicuous. Read More

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A Case of Pseudomyogenic Hemangioendothelioma of the Lower Extremity.

Ann Dermatol 2020 Oct 29;32(5):426-429. Epub 2020 Sep 29.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Pseudomyogenic hemangioendothelioma (PMH) is a rare vascular tumor and was recently recognized as a distinct entity. It has a predilection for young male adults and it frequently occurs in distal extremities. Although it is known to follow an indolent course, multi-focal presentation and local recurrence are common. Read More

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October 2020

Primary Cutaneous Solitary Fibrous Tumor on the Back.

Ann Dermatol 2020 Apr 11;32(2):155-158. Epub 2020 Mar 11.

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

Solitary fibrous tumors (SFT) are uncommon mesenchymal tumors. SFT have several synonyms including localized fibrous tumor, benign mesothelioma, localized fibrous mesothelioma, and submesothelial fibroma. SFT usually occur in the pleura or other serosal surfaces, but SFT can also develop in extrapleural areas including the nasal cavity, orbit, retroperitoneum, and pelvis. Read More

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A Case of Solitary Fibrous Tumor of Subungual Region.

Ann Dermatol 2020 Apr 11;32(2):146-150. Epub 2020 Mar 11.

Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.

Solitary fibrous tumor (SFT) is a relatively uncommon mesenchymal neoplasm that usually arises in the pleura, but also has been reported in numerous extrapleural locations, including cutaneous site. The skin lesion presents as a circumscribed nodule or tumor, mainly on the head and neck. A 41-year-old male presented with 6 months history of nail lesion without symptom on the left third finger. Read More

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The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.

Diagn Pathol 2021 Apr 20;16(1):32. Epub 2021 Apr 20.

Emeritus Professor, Kyung Hee University, School of Medicine Vice President of Asia, International Academy of Pathology, U2Labs, Jangwon Medical Foundation 68 Geoma-ro, Songpa-gu, Seoul, 05755, South Korea.

Background: Solitary Fibrous Tumor (SFT) is a distinct soft tissue neoplasm associated with NAB2-STAT6 gene fusion. It can involve a number of anatomic sites and exhibits a wide spectrum of histological features.

Main Body: Apart from diversity in morphological features seen even in conventional SFT, two histologic variants (fat-forming and giant cell-rich) are also recognized. Read More

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Role of a new acellular dermal matrix in a multistep combined treatment of dermatofibrosarcoma protuberans of the lumbar region: a case report.

J Med Case Rep 2021 Apr 20;15(1):180. Epub 2021 Apr 20.

Unit of Reconstructive and Plastic Surgery, Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, 71122, Foggia, Italy.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin fibroblastic tumor, with a high rate of recurrence. The treatment of DFSP is generally surgical, and wide local excision is the mainstay of surgical treatment. Therefore, complete assessment of all surgical margins is fundamental before definitive reconstruction. Read More

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Pilomatrixoma misdiagnosed as dermatofibrosarcoma protuberans.

Chin Med J (Engl) 2021 Apr 6. Epub 2021 Apr 6.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

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Association between surgical excision margins and outcomes in patients with dermatofibrosarcoma protuberans: A meta-analysis.

Dermatol Ther 2021 Apr 9:e14954. Epub 2021 Apr 9.

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Dermatofibrosarcoma protuberans (DFSP) is a tumor with low-grade malignancy and high recurrence rates. Wide local excision (WLE) is essential for DFSP, but its surgical excision margin is controversial. This study aimed to examine whether resection margin is associated with the prognosis of patients with DFSP by systematically reviewing related literature. Read More

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What is the best surgical treatment for dermatofibrosarcoma protuberans?

Authors:

Br J Dermatol 2021 04;184(4):e126-e147

Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing skin cancer that is primarily treated with surgery. Because this cancer can spread deep into the skin and surrounding tissue in an irregular way, it is notoriously difficult to ensure that it has been completely removed after conventional surgery and histological examination. Standard treatment in the UK is either wide local excision (WLE) or Mohs micrographic surgery (MMS). Read More

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Novel COL4A1-VEGFD gene fusion in myofibroma.

J Cell Mol Med 2021 May 8;25(9):4387-4394. Epub 2021 Apr 8.

de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.

Myofibroma is a benign pericytic tumour affecting young children. The presence of multicentric myofibromas defines infantile myofibromatosis (IMF), which is a life-threatening condition when associated with visceral involvement. The disease pathophysiology remains poorly characterized. Read More

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Dermatofibrosarcoma protuberans in pregnancy: a case series and review of the literature.

Int J Dermatol 2021 Apr 5. Epub 2021 Apr 5.

Department of Dermatology, Yale University, New Haven, CT, USA.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma, which has been reported in pregnancy. This case series reports the clinical and histopathological findings of DFSP in pregnancy.

Methods: Eighteen cases of DFSP, including six unreported cases and 12 cases from the literature, were identified. Read More

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Rechallenge with Multi-Targeted Tyrosine Kinase Inhibitors in Patients with Advanced Soft Tissue Sarcoma: A Single-Center Experience.

Cancer Manag Res 2021 18;13:2595-2601. Epub 2021 Mar 18.

Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Purpose: Chemotherapy and multi-targeted tyrosine kinase inhibitors (TKI) are important treatments for advanced soft tissue sarcomas, but the following treatment remains unclear after the failure of these drugs. This retrospective study investigated the efficacy and safety of multi-targeted TKI rechallenge in patients with advanced soft tissue sarcoma after the failure of previous TKI treatment.

Patients And Methods: Gastrointestinal stromal tumors, dermatofibrosarcoma protuberans and anaplastic lymphoma kinase translocation-positive inflammatory myofibroblastic tumor were excluded. Read More

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Dermatofibrosarcoma protuberans in the breast: Case report.

Authors:
Hwansoo Kim

Int J Surg Case Rep 2021 Apr 13;81:105773. Epub 2021 Mar 13.

Department of Surgery, Kangwon National University Hospital, Republic of Korea.

Introduction And Importance: Dermatofibrosarcoma protuberans (DFSP) represents about 1% of soft tissue sarcomas with an estimated incidence of 0.8-5.0 cases per million per year. Read More

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Fibrosarcomatous dermatofibrosarcoma protuberans in a seven-year-old boy.

Eur J Dermatol 2021 Feb;31(1):106-107

Department of Dermatology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan.

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February 2021

PDGFB RNA in situ hybridization for the diagnosis of dermatofibrosarcoma protuberans.

Mod Pathol 2021 Mar 24. Epub 2021 Mar 24.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

Dermatofibrosarcoma protuberans (DFSP) is a spindle cell neoplasm of the skin and superficial soft tissue with a tendency for locally aggressive behavior; metastatic potential coincides with fibrosarcomatous transformation. The vast majority of DFSPs harbor the t(17;22) translocation resulting in a COL1A1-PDGFB fusion that drives autocrine growth stimulation via PDGFB overexpression. Here, we examined the utility of PDGFB RNA chromogenic in situ hybridization (CISH) for the diagnosis of DFSP. Read More

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Preferentially expressed antigen in melanoma expression in nonmelanoma skin cancers and melanocytes in surrounding skin.

J Cutan Pathol 2021 Mar 15. Epub 2021 Mar 15.

Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.

Background: Immunohistochemistry for preferentially expressed antigen in melanoma (PRAME) has been studied in melanocytic lesions but not nonmelanoma skin cancers (NMSCs). This study evaluated PRAME expression in NMSCs and dermoepidermal junction (DEJ) melanocytes in the surrounding skin.

Methods: Ninety-nine NMSCs were studied: 23 Merkel cell carcinomas (MCCs), 25 well to poorly differentiated squamous cell carcinomas (SCCs), 14 basal cell carcinomas (BCCs), five basosquamous carcinomas, four sebaceous carcinomas, ten atypical fibroxanthomas, 11 dermatofibrosarcoma protuberans, and seven leiomyosarcomas. Read More

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[Case report: Epigastric dermatofibroma reconstruction by reverse abdominoplasty with umbilic transposition].

Ann Chir Plast Esthet 2021 Jun 11;66(3):261-267. Epub 2021 Mar 11.

Service de chirurgie plastique, reconstructrice et esthétique, CHRU de Nancy, 29, avenue du Maréchal-de-Lattre-de-Tassigny, 54035 Nancy, France.

Dermatofibrosarcoma is the most common cutaneous sarcoma. Its surgical management is a technical challenge due to the high amount of substance loss. We explain a new technique of abdominal wall reconstruction by a reverse abdominoplasty with umbilical transposition. Read More

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Giant Darier-Ferrand dermatofibrosarcoma protuberans of the abdomen and pelvis: a case report.

J Med Case Rep 2021 Mar 15;15(1):120. Epub 2021 Mar 15.

Surgical Oncology Department, Salah Azaiez Institute of Oncology, Tunis, Tunisia.

Background: Darier-Ferrand dermatofibrosarcoma (DFS) is a rare malignant cutaneous neoplasm characterized by local aggressiveness, high risk of recurrence, and low metastatic potential.

Case Presentation: A 60-year-old Tunisian man with recurrent abdominopelvic DFS for which he had undergone multiple excisions presented with an extensive DFS that invaded the external genitals. He underwent a large excision with emasculation and thin cutaneous graft of the abdominal wall and local skin flap in the pelvis. Read More

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