6,586 results match your criteria Dermatofibroma


Fat Necrosis with an Associated Lymphocytic Infiltrate Represents a Histopathologic Clue that Distinguishes Cellular Dermatofibroma from Dermatofibrosarcoma Protuberans.

J Cutan Pathol 2020 May 15. Epub 2020 May 15.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Background: Cellular dermatofibromas (CDFs) and dermatofibrosarcoma protuberans (DFSP) can be challenging to differentiate from one another. Morphologically, both entities commonly extend into the subcutis, exhibit high cellularity with limited cytologic atypia and have a mixed fascicular-to-storiform growth pattern. We sought to evaluate the significance of fat necrosis with an associated lymphocytic infiltrate as a histopathologic clue for distinguishing CDFs from DFSP. Read More

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http://dx.doi.org/10.1111/cup.13744DOI Listing

Congenital multiple clustered dermatofibroma on the abdomen.

Br J Dermatol 2020 May 10. Epub 2020 May 10.

Department of Dermatology, Ruprecht-Karls-University Medical Center, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bjd.19139DOI Listing

Epithelioid Fibrous Histiocytoma With Dot-Like Perinuclear ALK Expression and PRKAR2A-ALK Fusion.

Am J Dermatopathol 2020 May 1. Epub 2020 May 1.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR.

Epithelioid fibrous histiocytoma (EFH) is a rare, benign, cutaneous neoplasm. This fibrohistiocytic tumor was once believed to be a variant of fibrous histiocytoma, but EFH is now known to be a distinct entity based on the presence of ALK gene rearrangements in most cases. The pattern of immunohistochemical expression of ALK in EFH in the literature thus far describes both granular cytoplasmic staining and nuclear staining. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001666DOI Listing

Dermoscopy Training Effect on Diagnostic Accuracy of Skin Lesions in Canadian Family Medicine Physicians Using the Triage Amalgamated Dermoscopic Algorithm.

Dermatol Pract Concept 2020 3;10(2):e2020035. Epub 2020 Apr 3.

Dermatology, Eberhard Karls Universitat, Tubingen, Germany.

Background: Accurate identification of cutaneous lesions is an essential skill for family medicine physicians (FMPs). Studies show significant improvement in skin cancer detection with dermoscopy use. Frontline FMPs are an ideal target group for dermoscopy training. Read More

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http://dx.doi.org/10.5826/dpc.1002a35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190575PMC

Multicoloured rainbow pattern in a case of aneurysmal dermatofibroma.

Australas J Dermatol 2020 Apr 28. Epub 2020 Apr 28.

Department, Pathology, All India Institute of Medical Sciences, Bhubaneswar, India.

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http://dx.doi.org/10.1111/ajd.13302DOI Listing

Solitary adult xanthogranuloma in external auditory canal: Cyto-histopathological correlation of an uncommon entity at an uncommon site.

Diagn Cytopathol 2020 Apr 10. Epub 2020 Apr 10.

Department of Pathology, Dr Baba Saheb Ambedkar Hospital and Medical College, Rohini, Delhi, India.

Juvenile xanthogranulomas (JXG) are the most common type of self-limiting non-Langerhans cell histiocytosis (LCH) usually presenting in infancy and early childhood. Clinically, they present as solitary to multiple rounded cutaneous nodules which resolve over time. Adult type xanthogranulomas (AXG), though histologically similar to JXG, are usually single and do not regress spontaneously. Read More

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http://dx.doi.org/10.1002/dc.24430DOI Listing

Fibrous histiocytoma/dermatofibroma in children: the same as adults?

Hum Pathol 2020 Apr 1;99:107-115. Epub 2020 Apr 1.

Department of Pathology, Ospedale Pediatrico Bambino Gesú, Rome, 00165, Italy.

Fibrous histiocytoma (FH) or dermatofibroma is a common cutaneous lesion mostly seen in adults and rare in the first two years of life. Two hundred sixty-seven patients younger than 18 years with a diagnosis of FH or dermatomyofibroma, a lesion with morphologic overlap with FH, were identified from the files of a single institution, with only 13 (4.8%) occurring in patients younger than 5 years. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.03.012DOI Listing

Granuloma annulare mimicking eruptive dermatofibroma in an HIV-positive male: A challenge with distinct dermatoscopic findings.

Dermatol Ther 2020 Apr 3:e13375. Epub 2020 Apr 3.

Dermatology Department, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/dth.13375DOI Listing

Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions.

Cureus 2020 Feb 11;12(2):e6955. Epub 2020 Feb 11.

Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA.

Cutaneous tender tumors manifest as painful dermal or subcutaneous masses. Acronyms, a memory aid created from the initial letters of other words, can be used to assist in recalling a list of conditions. We report the case of a man who presented with a painful lesion on his leg; 15 years earlier, hot solder had embedded beneath his skin at that location. Read More

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http://dx.doi.org/10.7759/cureus.6955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067514PMC
February 2020

Benign fibrous histiocytoma of the lower lip.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S97-S100. Epub 2020 Feb 28.

Department of Oral Pathology, Microbiology and Forensic Odontology, Himachal Institute of Dental Sciences, Paonta Sahib, Himachal Pradesh, India.

The fibrous histiocytoma is a soft-tissue neoplasm of the biphasic cell population of fibroblasts and histiocytes that affects the dermis and the subcutaneous tissue. The objective of this article is to report a case of benign fibrous histiocytoma (BFH) of the lower lip in a 32-year-old female patient with a chief complaint of swelling in the lower lip for the past 1 month. With diagnostic clinical hypothesis of fibrous hyperplasia, fibrous histiocytoma and mucocele, an excisional biopsy was performed. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_351_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069156PMC
February 2020

A rare presentation of benign fibrous histiocytoma in the maxilla.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S73-S76. Epub 2020 Feb 28.

Department of Oral and Maxillofacial Pathology and Oral Microbiology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India.

Fibrous histiocytoma is a soft-tissue tumor that may present as a fibrous mass anywhere in the human body. The involvement of the oral cavity is rare. We here report a case of benign fibrous histiocytoma localized in the maxilla. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_321_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069126PMC
February 2020

When to suspect a non-melanoma skin cancer.

BMJ 2020 Mar 11;368:m692. Epub 2020 Mar 11.

Department of Dermatology, Nottingham NHS Treatment Centre, Nottingham NG7 2FT, UK.

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http://dx.doi.org/10.1136/bmj.m692DOI Listing

Hemosiderotic Dermatofibroma: A Rare and Atypical Variant Capable of Clinically Resembling Melanoma.

Cureus 2020 Jan 22;12(1):e6736. Epub 2020 Jan 22.

Plastic Surgery, The Johns Hopkins University School of Medicine, Baltimore, USA.

A dermatofibroma (DF) is a common, benign tumor composed of fibroblastic and histiocytic cells. DF presents clinically with several different reported variants. One rare variant is hemosiderotic DF (HDF), which is made up of small blood vessels and hemosiderin deposits. Read More

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http://dx.doi.org/10.7759/cureus.6736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034752PMC
January 2020

[Calcifying fibrous tumor: a clinicopathological analysis of 32 cases].

Zhonghua Bing Li Xue Za Zhi 2020 Feb;49(2):129-133

Department of Pathology, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University; People's Hospital of Henan University, Zhengzhou 450003, China.

To investigate the clinicopathological characteristics, histogenesis, immunophenotypes, molecular genetic characteristics, diagnosis and differential diagnosis of calcifying fibrous tumors (CFT). A total of 32 cases of CFT (22 cases from Henan Provincial People's Hospital and 10 cases from PLA Army Medical Center) diagnosed between June 2009 and February 2019 were reviewed. The clinical and pathologic data were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.02.005DOI Listing
February 2020

[The histiocytoma of the oropharynx (clinical cases)].

Vestn Otorinolaringol 2019 ;84(6):90-93

Federal Research Clinical Center of Otorhinolaryngology of Federal Medical Biological Agency of Russia, Moscow, Russia, 123182.

The paper presents a case of rare localization histiocytoma of the oropharynx. Some authors consider the existence of this category of tumors controversial, others prefer to consider them tumors of unclear Genesis. Benign fibrous histiocytoma is quite common in the form of a small node with fairly clear boundaries, most often localized on the skin of various parts of the body. Read More

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http://dx.doi.org/10.17116/otorino20198406190DOI Listing
February 2020

[Clinicopathologic and molecular characteristics of myxoid angiomatoid fibrous histiocytoma].

Zhonghua Zhong Liu Za Zhi 2020 Jan;42(1):37-43

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical School, Hangzhou 310014, China.

To investigate the molecular genetic and clinicopathologic characteristics, immunophenotypes, diagnostic and differential diagnostic features of myxoid angiomatoid fibrous histiocytoma (MAFH). Three cases of MAFH were collected from the archives of Zhejiang Provincial People's Hospital between January 2015 to August 2018. The clinical and radiologic features, histomorphology, immunohistochemistry, molecular genetics and prognosis were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2020.01.005DOI Listing
January 2020

Clear-cell variant of superficial cutaneous leiomyosarcoma associated with RB1 mutation: Clinical, dermoscopic, and histopathological characteristics.

J Cutan Pathol 2020 Jun 9;47(6):571-575. Epub 2020 Feb 9.

Dermatology Clinic, Department Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Leiomyosarcoma is a relatively rare soft tissue tumor whose clear-cell variant has only been reported in leiomyosarcomas of the uterus. We report here for the first time a primary cutaneous clear-cell leiomyosarcoma in the trunk skin of a 49-year-old man, characterized by a very indolent clinical and dermoscopic presentation, mimicking a dermatofibroma. Genetic analysis of the otherwise healthy patient revealed a germline mutation in the retinoblastoma 1 gene (RB1); the same mutation was found in his son, who had previously developed retinoblastoma. Read More

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http://dx.doi.org/10.1111/cup.13655DOI Listing

Cutaneous "fibroma-like" perivascular epithelioid cell tumor: A case report and review of literature.

J Cutan Pathol 2020 Jun 27;47(6):548-553. Epub 2020 Jan 27.

Department of Pathology, Yong Loo Lin School of Medicine, National University Health System and National University of Singapore, Singapore, Singapore.

Perivascular epithelioid cell tumors (PEComas) are a group of lesions sharing the common features of co-expression of melanocytic and myogenic markers, with focal association of the cells with vascular walls. The PEComa group exhibits a wide range of morphologies. A "fibroma-like" variant of PEComa has been recently described. Read More

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http://dx.doi.org/10.1111/cup.13647DOI Listing

Basal Cell Carcinoma Overlying a Dermatofibroma: A Rare Collision Tumor.

Dermatol Pract Concept 2020 31;10(1):e2020015. Epub 2019 Dec 31.

Department of Dermatology and Venereology, University Hospital Centre Zagreb, Croatia.

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http://dx.doi.org/10.5826/dpc.1001a15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936626PMC
December 2019

Primary Intraosseous Xanthomas of the Jaws: A Series of Six Cases Including an Example with Formation of Apoptosis-Related Hyaline Globules, So-Called "Thanatosomes".

Head Neck Pathol 2020 Jan 8. Epub 2020 Jan 8.

Division of Oral and Maxillofacial Pathology, Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, 515 Delaware Street SE 16-206B, Minneapolis, MN, 55455, USA.

Primary intraosseous xanthomas of the jaws (PIXJ) are rare and predominantly affect the posterior mandible (86%) of normolipemic patients, with a mean age of 30 years and no gender predilection. Clinically, PIXJ exhibit indolent biologic behavior; curettage is considered treatment of choice. Only 36 PIXJ have been reported. Read More

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http://dx.doi.org/10.1007/s12105-020-01126-2DOI Listing
January 2020

The first total vertebral involvement of benign fibrous histiocytoma: A case report and literature review.

J Bone Oncol 2020 Feb 20;20:100274. Epub 2019 Dec 20.

Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Fengyang Rd 415#, Huangpu District, Shanghai, China.

Background: Benign fibrous histiocytoma (BFH) is a rare bone tumor, extremely seldom in the spine.

Methods: We present a 52-year-old patient diagnosed with a BFH in the thoracic spine treated with total en bloc spondylectomy. A review of the published literature was also conducted. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940612PMC
February 2020

Could cathepsin-k be a driver of the myofibroblastic differentiation observed in dermatofibroma, atypical fibroxanthoma and pleomorphic dermal sarcoma?

Acta Histochem 2020 Feb 27;122(2):151498. Epub 2019 Dec 27.

Pathology Unit, S. Orsola Malpighi Hospital, Bologna University, Bologna, Italy.

Dermatofibroma (BFH), atypical fibroxanthoma (AFX) and dermal pleomorphic sarcoma (DPS) are skin-based soft-tissue neoplasms of uncertain lineage. They are classified as "fibrohistiocytic" neoplasms, even if the World Health Organization stated that this term connotes a polymorphic group of lesions that histologically resemble fibroblasts and histiocytes. It is well-known that this group of lesions shows a "fibro-histiocytic-dendritic" and/or a "myofibroblastic" phenotype, even within the same lesion. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.151498DOI Listing
February 2020

Desmoplastic stromal changes in cutaneous neural granular cell tumors: An under-recognized histopathologic feature of diagnostic and prognostic importance.

J Cutan Pathol 2020 May 30;47(5):431-438. Epub 2019 Dec 30.

Department of Pathology, Western General Hospital, Edinburgh, UK.

Background: Granular cell tumors (GCTs) are uncommon mucocutaneous and soft tissue neoplasms with distinctive histopathologic appearance but controversial histogenesis. Herein, we report a variant of cutaneous GCT featuring extensive desmoplastic stroma which may result in diagnostic difficulties with mesenchymal proliferations, particularly a dermatofibroma.

Methods: Following a recent case of GCT with prominent stromal desmoplasia, we reviewed all cases diagnosed as GCT during the past 10 years accessioned at the dermatopathology unit in a tertiary university hospital. Read More

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http://dx.doi.org/10.1111/cup.13635DOI Listing

Spectral indexes obtained by implementation of the fractional Fourier and Hermite transform for the diagnosis of malignant melanoma.

Biomed Opt Express 2019 Dec 4;10(12):6043-6056. Epub 2019 Nov 4.

CICESE, División de Física Aplicada, Departamento de Óptica, Carretera Ensenada-Tijuana, No. 3918, Fraccionamiento Zona Playitas, Ensenada, B.C., C.P. 22860, Mexico.

Many people suffer from different skin diseases, which can be diverse and varied. Most skin diseases cause disorders in the skin, such as changes in color, texture, and appearance manifesting in spots, swelling, scaling, ulcers, etc. One of the diseases that represents a serious health problem is skin cancer. Read More

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http://dx.doi.org/10.1364/BOE.10.006043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913402PMC
December 2019

Aneurysmal benign fibrous histiocytoma of the anal canal: a rare differential diagnosis.

Int J Colorectal Dis 2020 Feb 16;35(2):347-349. Epub 2019 Dec 16.

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Background: To our knowledge, we report the first case of an aneurysmal benign fibrous histiocytoma occurring in the anal canal.

Methods: Clinical, histological, radiological and surgical data pertaining to this patient were analysed. Additionally, a literature review on aneurysmal benign fibrous histiocytoma was conducted. Read More

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http://dx.doi.org/10.1007/s00384-019-03472-2DOI Listing
February 2020

High-frequency ultrasound in the diagnosis of selected non-melanoma skin nodular lesions.

Postepy Dermatol Alergol 2019 Oct 12;36(5):572-580. Epub 2019 Nov 12.

Chair and Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.

Introduction: Ultrasonographic examination is commonly used in an outpatient setting, possibly due to its low cost, low risk for patients and the possibility to obtain real time images. Typically used heads have the frequency ranging from 7.5 to 12 MHz. Read More

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http://dx.doi.org/10.5114/ada.2019.89505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906959PMC
October 2019

State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS).

Int J Dermatol 2020 Mar 28;59(3):321-325. Epub 2019 Nov 28.

Fundación Piel Sana Academia Española de Dermatología, Madrid, Spain.

Background: The use of Mohs micrographic surgery (MMS) for rare cutaneous tumors is poorly defined. We aim to describe the demographics, tumor presentation and topography, surgery characteristics and complications of MMS for rare cutaneous tumors in a national registry.

Methods: Prospective cohort study of patients treated with MMS in Spain between July 2013 and June 2018. Read More

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http://dx.doi.org/10.1111/ijd.14732DOI Listing

A rare case of benign fibrous histiocytoma of the cornea.

Indian J Ophthalmol 2019 12;67(12):2064-2066

Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Fibrous histiocytoma (FH) commonly occurs in the superficial layers of the skin. Orbit and limbus are documented ophthalmic sites of involvement but isolated corneal FH has never been reported in literature. We present the first case of FH exclusively involving the cornea where a 10-year-old male child presented with a 3-month history of a painless growth on the superior cornea of the right eye with deterioration of vision. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1648_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896551PMC
December 2019

Multiple eruptive dermatofibromas.

Presse Med 2019 Nov 11;48(11 Pt 1):1353-1354. Epub 2019 Nov 11.

Habib Thameur Hospital, Research Unit "Genodermatoses and cancers LR12SP03", dermatology department, Tunis, Tunisia.

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http://dx.doi.org/10.1016/j.lpm.2019.09.002DOI Listing
November 2019

Atypical fibroxanthoma, rare and often unrecognized cutaneous soft tissue tumor - a case report and review of the literature.

Cesk Patol 2019 ;55(3):182-186

Atypical fibroxanthoma (AFX) is a rare cutaneous soft tissue tumor typically occurring in the elderly on sun exposed skin. Histologically, it is composed of pleomorphic, atypical cells with multiple mitoses including atypical mitotic figures resembling undifferentiated malignant tumor. AFX is considered to be a benign tumor with almost uniformly excellent prognosis following conservative therapy if strict diagnostic criteria are applied. Read More

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December 2019

Perineural Invasion as a Clue to Malignant Behavior in a Dermatofibroma.

Am J Dermatopathol 2019 Nov 12. Epub 2019 Nov 12.

Dermatopatología Diagnóstica, Salamanca, Spain.

Dermatofibroma (DF) represents one of the most common mesenchymal proliferations of the skin. Their recurrence rate, even when incompletely excised, is very low, whereas the atypical, aneurysmal, and cellular variants have recurrence rates of up to 20% each. Extraordinary rare malignant lesions with metastases to lymph nodes and/or lung have been described. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001570DOI Listing
November 2019

Dermatofibroma With Sebaceous Induction: Dermoscopic Clues to Improve Recognition.

Dermatol Pract Concept 2019 Oct 31;9(4):315-317. Epub 2019 Oct 31.

Department of Dermatology, University of Virginia Health System, Charlottesville, VA, USA.

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http://dx.doi.org/10.5826/dpc.0904a18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830549PMC
October 2019

Imaging Features of Sclerosing Angiomatoid Nodular Transformation in Spleen.

J Comput Assist Tomogr 2019 Nov/Dec;43(6):863-869

From the Department of Radiology, the First Affiliated Hospital, College of Medicine, Jiaxing University.

Purpose: The purpose of this study was to evaluate the features of sclerosing angiomatoid nodular transformation (SANT) in spleen on the imaging of computed tomography (CT) and magnetic resonance (MR).

Materials And Methods: From July 2006 to April 2017, 12 patients with SANT confirmed by pathology were evaluated in a retrospective study. Eight patients were with CT imaging only, 2 patients were with MR imaging only, and 2 patients were with both CT and MR. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867663PMC
November 2019
1.602 Impact Factor

Conjunctival Benign Fibrous Histiocytoma in a 57-year-old man.

Rom J Ophthalmol 2019 Jul-Sep;63(3):273-276

OphtalmoEsterel, Saint-Raphaël, France.

To report a case of benign fibrous histiocytoma of the conjunctiva involving the cornea, an uncommon ocular surface tumor. A 57-year-old patient came in our service complaining of a progressively enlarging conjunctival mass temporally to the limbus and invading the adjacent cornea of the left eye. The approach consisted in surgical excision followed by cryotherapy on the edges and on the base of the excision site and amniotic membrane patch reconstruction of the ocular surface defect. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820492PMC
December 2019
1 Read

Corneoscleral locally aggressive fibrous histiocytoma in Xeroderma Pigmentosum patient: A case report.

Saudi J Ophthalmol 2019 Jul-Sep;33(3):297-299. Epub 2017 Aug 7.

Pathology & Laboratory Medicine Department, King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia.

Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder that has been found in all continents and racial groups in relation to faulty repair of DNA with sun exposure. Several cutaneous and ocular tumors have been described in relation to XP including fibrous histiocytoma (FH). The diagnosis of conjunctival FH is challenging owing to the rarity of this tumor and the diversity of its classification into benign, locally aggressive and malignant. Read More

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http://dx.doi.org/10.1016/j.sjopt.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819724PMC
August 2017
1 Read

Solitary papule on the leg.

Cutis 2019 Sep;104(3):173;187-188

Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, USA.

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September 2019
0.594 Impact Factor

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?

Authors:
Jason L Hornick

Mod Pathol 2020 01 25;33(Suppl 1):56-65. Epub 2019 Oct 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

In the 2018 World Health Organization Classification of Skin Tumors, a wide range of predominantly benign mesenchymal neoplasms are included in the fibroblastic, myofibroblastic, and "fibrohistiocytic" categories. By far the most common of these tumors is dermatofibroma (fibrous histiocytoma). There are many histologic variants of dermatofibroma, some of which (cellular, aneurysmal, and atypical) are associated with a higher risk of local recurrence; these variants may be mistaken for more aggressive tumor types, including sarcomas. Read More

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http://dx.doi.org/10.1038/s41379-019-0388-4DOI Listing
January 2020
1 Read

A Case of Atrophic Dermatofibroma Overexpressing Matrix Metalloproteinase-1.

Case Rep Dermatol 2019 Sep-Dec;11(3):264-267. Epub 2019 Oct 1.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

This case report describes the importance of considering this tumor as one of the differential diagnoses when we encounter a flat and/or atrophic and depressible lesion in the upper portion of the trunk. Read More

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http://dx.doi.org/10.1159/000503136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792423PMC
October 2019
1 Read

A Rare Case of Atrophic Dermatofibroma Featuring Linear Skin Dimple.

Case Rep Dermatol 2019 Sep-Dec;11(3):256-259. Epub 2019 Sep 30.

Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.

Dermatofibroma (DF) is a benign skin tumor that is well-known among dermatologists. We herein present a rare case of atrophic dermatofibroma presenting linear skin dimpling. The patient was a 25-year-old woman with a history of wild-type recessive dystrophic epidermolysis bullosa who had noticed linear concavity on her right lateral back 1 year before her initial presentation. Read More

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http://dx.doi.org/10.1159/000503413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792431PMC
September 2019
2 Reads

Prospective Study of Q Switched Alexandrite Laser 755 nm and V Beam Pulsed Dye Laser 595 nm in Dermatofibroma.

Actas Dermosifiliogr 2020 Apr 13;111(3):257-260. Epub 2019 Oct 13.

Clínica Dermatológica Internacional, Madrid, España.

Pulsed dye and carbon dioxide lasers have been applied in dermatofibroma with clinical improvement. We treated 23 dermatofibromas two times at a 4-week interval with Q-Switched alexandrite laser 755nm (7.5J/cm, 3mm, 50ms). Read More

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http://dx.doi.org/10.1016/j.ad.2018.09.017DOI Listing
April 2020
1 Read

Cutaneous Syncytial Myoepithelioma: A Nondescript Skin Tumor With Serious Diagnostic Pitfalls.

Int J Surg Pathol 2020 Feb 6;28(1):63-67. Epub 2019 Oct 6.

UC San Diego Health, San Diego, CA, USA.

Cutaneous syncytial myoepithelioma (CSM) is a rare tumor with a nondescript clinical presentation in the skin. It represents a relatively uncommon diagnostic entity with approximately 50 examples in the literature to date. We present a 36-year-old man with a new, tender 3-mm firm pink papule on the left bicep, in which a superficial shave technique produced a diagnostic challenge. Read More

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http://dx.doi.org/10.1177/1066896919879755DOI Listing
February 2020
1 Read

Management of giant benign fibrous histiocytoma in the spinal region with pleural involvement: A case report.

Medicine (Baltimore) 2019 Sep;98(39):e17144

Department of Orthopaedic Surgery.

Rationale: Benign fibrous histiocytoma with pleural involvement in spinal region is a highly unusual disease with no standard curative managements yet. The objective of this study is to report an extremely rare case of a giant benign fibrous histiocytoma with pleural involvement in spinal region successfully operated by posterior spinal surgery. The management of these unique cases has yet to be well-documented. Read More

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http://dx.doi.org/10.1097/MD.0000000000017144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775359PMC
September 2019
1 Read

SOX9 Immunohistochemistry in the Distinction of Angiomatoid Fibrous Histiocytoma From Histologic Mimics: Diagnostic Utility and Pitfalls.

Appl Immunohistochem Mol Morphol 2019 Sep 18. Epub 2019 Sep 18.

Department of Pathology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh.

Angiomatoid fibrous histiocytoma (AFH) can be diagnostically difficult because of its varied histologic appearance and potential to occur at unusual sites. The identification of recurrent rearrangements (EWSR1-CREB1, EWSR1-ATF1, and FUS-ATF1) is a helpful diagnostic tool. Additional immunohistochemical markers in AFH could aid in restricting the differential diagnosis and selecting appropriate cases for targeted molecular studies. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000809DOI Listing
September 2019
20 Reads

Difficult diagnosis of Angiomatoid Fibrous Histiocytoma of the leg mimicking a benign condition.

J Radiol Case Rep 2019 Apr 30;13(4):38-45. Epub 2019 Apr 30.

Musculoskeletal Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Angiomatoid fibrous histiocytoma is a rarely metastasizing soft-tissue tumor of low-grade malignancy. Here we report a case of angiomatoid fibrous histiocytoma located in the leg of a 15-year-old female. This case is of particular interest due to its radiological features that led to raise two questions concerning the nature of the disease (is it reactive or tumoral?) and its site of origin (within soft tissues or the tibial periosteum?). Read More

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http://dx.doi.org/10.3941/jrcr.v13i4.3414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743639PMC
April 2019
2 Reads

Primary Breast Liposarcoma.

J Radiol Case Rep 2018 Dec 31;12(12):10-15. Epub 2018 Dec 31.

Department of Radiology, Wockhardt Hospital, Mumbai, India.

Liposarcoma of breast is a rare breast malignancy. It accounts for 0.3% of the breast sarcomas. Read More

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http://dx.doi.org/10.3941/jrcr.v12i12.3457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743859PMC
December 2018
3 Reads

Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas.

J Invest Dermatol 2020 Mar 4;140(3):624-635.e7. Epub 2019 Sep 4.

St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, Guy's Hospital, London, United Kingdom. Electronic address:

Dermatofibromas are common benign skin lesions, the etiology of which is poorly understood. We identified two unrelated pedigrees in which there was autosomal dominant transmission of multiple dermatofibromas. Whole exome sequencing revealed a rare shared heterozygous missense variant in the F13A1 gene encoding factor XIII subunit A (FXIII-A), a transglutaminase involved in hemostasis, wound healing, tumor growth, and apoptosis. Read More

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http://dx.doi.org/10.1016/j.jid.2019.08.441DOI Listing
March 2020
3 Reads

Risk-Aware Machine Learning Classifier for Skin Lesion Diagnosis.

J Clin Med 2019 Aug 17;8(8). Epub 2019 Aug 17.

Department of Electrical and Computer Engineering, University of Houston, Houston, TX 77004, USA.

Knowing when a machine learning system is not confident about its prediction is crucial in medical domains where safety is critical. Ideally, a machine learning algorithm should make a prediction only when it is highly certain about its competency, and refer the case to physicians otherwise. In this paper, we investigate how Bayesian deep learning can improve the performance of the machine-physician team in the skin lesion classification task. Read More

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http://dx.doi.org/10.3390/jcm8081241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723257PMC
August 2019
3 Reads

Dermoscopic patterns of dermatofibroma in 72 Chinese patients.

Chin Med J (Engl) 2019 Sep;132(17):2121-2122

Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

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http://dx.doi.org/10.1097/CM9.0000000000000406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793798PMC
September 2019
1 Read

Endoscopic submucosal dissection of tracheal deep benign fibrous histiocytoma using hybrid knife.

Onco Targets Ther 2019 11;12:5609-5613. Epub 2019 Jul 11.

Department of Pulmonary and Critical Care Medicine, First Hospital of China Medical University, Shenyang, People's Republic of China.

Deep benign fibrous histiocytoma (FH) is an uncommon and poorly recognized tumor that arises in subcutaneous or deep soft tissue. Deep benign FH of the trachea is even more rare. Deep benign FH recurs in approximately 20% of cases, so surgical resection is the recommended treatment for FH. Read More

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http://dx.doi.org/10.2147/OTT.S213747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628974PMC
July 2019
5 Reads
1.342 Impact Factor

Scanning electron microscopy of dermatofibroma.

An Bras Dermatol 2019 Jul 29;94(3):358-360. Epub 2019 Jul 29.

Post-Graduation Program in Health and Behavior, Universidade Católica de Pelotas, Pelotas (RS), Brazil.

Dermatofibroma is a proliferation of spindle cells located in the dermis. We used scanning electron microscopy to examine two histologically confirmed lesions and observed preserved collagen bundles in the perilesional area. In the lesional area, the collagen was denser, without formation of bundles. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668944PMC
July 2019
4 Reads