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    A Squamous Cell Carcinoma and a Malignant Fibrous Histiocytoma Developing in a Patient with a Mature Cystic Teratoma.
    Case Rep Oncol 2017 Jan-Apr;10(1):98-105. Epub 2017 Jan 19.
    Dicle University, Department of Gynecology and Obstetrics, Dicle, Turkey.
    We present a very rare case of malignant transformation of a benign mature cystic teratoma. The pathology report revealed malignant transformation of both the epithelial and sarcomatous elements of a benign dermoid cyst. To the best of our knowledge, this appears to be the third case of a malignant fibrous histiocytoma and a squamous cell carcinoma developing from a mature cystic teratoma. Read More

    Case Report of Four Different Primary Mesenteric Neoplasms and Review of Literature.
    Iran Red Crescent Med J 2016 Oct 21;18(10):e28920. Epub 2016 Jun 21.
    Gazi Yasargil Teaching and Research Hospital, Department of General Surgery, Diyarbakir, Turkey.
    Introduction: It is rare for primary tumors to arise from the mesentery. Lymphangiomas appear as congenital malformations of the lymphatic system or benign neoplasms as a large, thin-walled, often multilocular cyst. Mesenteric infiltration is common and during surgical treatment, adjustment of structures such as the bowel and resection of the spleen may be required. Read More

    Outcome of Flap Surgeries in Dermatosurgical Unit at a Tertiary Care Centre in India with a Review of Literature.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):226-231
    Department of Dermatology, Bangalore Medical College and Research Institute, Victoria Hospital, Bengaluru, Karnataka, India.
    Introduction: Flap surgeries are an excellent choice for closing large defects following trauma, excision of carcinomas or removal of large lesions. This article is a prospective interventional study of various flap surgeries performed at a tertiary care centre with their outcome in dermatosurgical unit.

    Materials And Methods: A total of 35 flap surgeries performed from January 2012 to December 2014 formed part of the study. Read More

    Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall.
    Pol J Pathol 2016 ;67(3):291-294
    The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic.
    Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Read More

    Sclerosing Dermatofibrosarcoma Protuberans Shows Significant Overlap With Sclerotic Fibroma in Both Routine and Immunohistochemical Analysis: A Potential Diagnostic Pitfall.
    Am J Dermatopathol 2017 Feb;39(2):83-88
    Departments of *Dermatology, and †Pathology, University of California San Francisco, San Francisco, CA.
    Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-to-intermediate grade sarcoma with several histologic variants, including pigmented (Bednar tumor), sclerosing, myxoid, atrophic, and DFSP with fibrosarcomatous changes. Two patterns of sclerosis in DFSP can be observed, a sclerotic fibroma-like pattern and a morphea/lichen sclerosus-like pattern. Partial biopsies of sclerosing DFSPs with the sclerotic fibroma pattern can be misdiagnosed as sclerotic fibroma or other benign sclerosing tumors (eg, perineurioma, dermatofibroma). Read More

    Rotation Flap Closure of Moderate Size Scalp Defects - Technique and Outcome.
    J Clin Diagn Res 2016 Nov 1;10(11):PD21-PD23. Epub 2016 Nov 1.
    Assistant Professor, Deparment of Surgery, Believers Church Medical College, Hospital , Tiruvalla, Kerala, India .
    Many patients present to general surgeons with scalp lesions which require wide local excision with margin, following which the defect is too large to be closed primarily. These lesions can be benign or malignant. Skin grafting of these defects gives poor cosmetic outcome. Read More

    A 64-Year-Old Woman With an Atrophic Plaque on the Thigh-Question.
    Am J Dermatopathol 2017 Jan;39(1):45-46
    *The Ohio State University Wexner Medical Center, Columbus, OH; †Division of Dermatology, Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH; and ‡Division of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Gahanna, OH.

    Mycobacterium haemophilum: A report of cutaneous Infection in a Patient with end-stage renal disease.
    Int J Mycobacteriol 2016 Dec 9;5 Suppl 1:S236. Epub 2016 Nov 9.
    Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
    Introduction: Mycobacterium haemophilum is a slow-growing nontuberculous mycobacterium (NTM) that can cause ulcerating cutaneous or subcutaneous nodular skin lesions in immunocompromised and immunocompetent patients. Acid-fast staining cannot distinguish NTM from M. tuberculosis; culturing at two temperatures with iron-supplemented media and polymerase chain reaction (PCR) are needed for optimal detection of M. Read More

    Dermatofibroma of the Eyelid with Monster Cells.
    Surv Ophthalmol 2016 Dec 21. Epub 2016 Dec 21.
    Harvard Medical School; The Department of Dermatology, Massachusetts General Hospital.
    Dermatofibromas are most frequently encountered in women on the lower extremities, often after minor trauma. A 64-year-old woman developed a recurrent lesion of the right lower eyelid. It harbored "monster cells" that were large, with either multiple nuclei or a single, large, convoluted and hyperchromatic nucleus. Read More

    FOSB is a Useful Diagnostic Marker for Pseudomyogenic Hemangioendothelioma.
    Am J Surg Pathol 2016 Dec 22. Epub 2016 Dec 22.
    Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
    Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a distinctive vascular neoplasm of intermediate biological potential with a predilection for young adults and frequent multifocal presentation. Pseudomyogenic hemangioendothelioma is characterized by loose fascicles of plump spindled and epithelioid cells with abundant eosinophilic cytoplasm and coexpression of keratins and endothelial markers. Recently, a SERPINE1-FOSB fusion has been identified as a consistent genetic alteration in pseudomyogenic hemangioendothelioma. Read More

    Plaque-Like Myofibroblastic Tumor of Infancy: A New Case Report and Literature Review.
    Pediatr Dermatol 2016 Dec 16. Epub 2016 Dec 16.
    Department of Molecular Medicine, Sapienza University of Rome, Azienda Policlinico Umberto I, Rome, Italy.
    Plaque-like myofibroblastic tumor of infancy is a rare entity, with only a few reports described in the literature. Herein we present a new case of a nodular plaque-like lesion of the left lower back in an 18-month-old boy. The lesion might initially be thought to be a dermatofibroma, but the overall characteristics suggested the diagnosis of plaque-like myofibroblastic tumor of infancy. Read More

    Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically.
    Semin Diagn Pathol 2016 Nov 29. Epub 2016 Nov 29.
    From the Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Health System, Charlottesville, VA, USA.
    This review considers neoplastic lesions that originate in the skin, and which have the potential to imitate hematopoietic proliferations at a histological level. They include lymphoepithelioma-like carcinoma, Merkel cell carcinoma, benign lymphadenoma, pseudolymphomatous angiosarcoma, lymphadenoid dermatofibroma, lymphomatoid atypical fibroxanthoma, histiocytoid (epithelioid) hemangioma, and inflamed melanocytic lesions. The clinical and pathological features of those tumors are considered. Read More

    A Tete - a - tete of benign, borderline and malignant fibrohistiocytic tumor.
    Iran J Pathol 2016 ;11(3):286-290
    Dept. of Surgery, Sri Siddhartha Medical College, Tumkur, Karnataka - 572104, India.
    Dermatofibrosarcoma protruberans is a relatively uncommon slow growing, locally aggressive fibrous tumor of the skin. It has a prospensity of progressing to fibrosarcomatous change in 5% of the cases. We present a case of a 56 yr old male with presented to the outpatient department of surgery, Sri Siddhartha Medical College, Tumkur with a chest swelling in 2013. Read More

    An Atrophic Plaque with Arborizing Vessels.
    Case Rep Dermatol 2016 Sep-Dec;8(3):239-242. Epub 2016 Sep 12.
    Skingroup Dermatology Clinic, Monterrey, Mexico.
    Dermatofibromas are a common finding in the daily clinical practice. Most lesions are found incidentally or because patients seek medical attention due to the aspect of the lesion. Rare variants of dermatofibroma such as aneurismatic or atrophic dermatofibroma can be encountered simultaneously; thus, these combined features may raise the possibility of other diagnoses to be considered. Read More

    Dermatofibroma of the Auricle.
    J Drugs Dermatol 2016 Oct;15(10):1270-1272
    An adolescent male presented to the office with a 3-month history of a small left ear mass located on the posterior helix. Although the patient was asymptomatic, the decision was made to remove the mass in the operating room and send for pathology. Following excision, the mass was stained and examined by the pathologist. Read More

    Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy.
    Case Rep Dermatol 2016 May-Aug;8(2):210-217. Epub 2016 Aug 9.
    Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.
    Introduction: The development of cutaneous neoplasms at immunization sites following vaccination is uncommon, and only few have been reported in the literature worldwide. We report an unusual case of an ulcerated giant dermatofibroma that developed as a chronic nonhealing plaque in the immunization scar of a young boy after vaccination.

    Case Report: A 13-month-old Chinese boy presented with an unusual skin reaction on the vaccination site at the right anterolateral thigh following a routine intramuscular injection of '5-in-1' (diphtheria, tetanus, pertussis, polio and Haemophilus influenzae B) vaccine at 4 months of age. Read More

    Multinucleate cell angiohistiocytoma of the lower vermilion lip: an unusual site.
    G Ital Dermatol Venereol 2016 Oct 5. Epub 2016 Oct 5.
    DISSAL, Department of Dermatology, IRCCS-AOU S. Martino-IST, University of Genoa,Genoa, Italy -
    Multinucleate cell angiohistiocytoma (MCA) represent an uncommon benign fibrohistiocytic vascular lesion that sometimes may go undiagnosed because of its clinical and hystopathological similarities with benign fibrous histiocytoma and other soft-tissue neoplasms especially when localized on oral cavity or semi mucosa. We report the case of a solitary multinucleate cell angiohistiocytoma on the lower lip of a 46-year old woman suggesting that this rare lesion should be considered in the differential diagnosis of the oral soft-tissue neoplasms. Read More

    Multiple Eruptive Dermatofibromas Masquerading as Cutaneous Lymphoma.
    Indian J Dermatol 2016 Sep-Oct;61(5):581
    Department of Pathology, St. John's Medical College and Hospital, Bengaluru, Karnataka, India.
    A 34-year-old male came with complaints of multiple firms to hard nontender, nonitchy nodules, measuring 2 cm × 2 cm to 1 cm × 1.5 cm, present predominantly over the lower limbs. This condition started 5 years back as a single nodule over the thigh but gradually increased in number and size with time to involve both lower limbs. Read More

    Georgian Med News 2016 Jul(256-257):11-3
    Academic Teaching Hospital Dresden-Friedrichstadt, Department of Dermatology and Allergology; Institute of Pathology "Georg Schmorl"; Department of Anesthesiology and Intensive Care Medicine, Emergency Medicine and Pain Management, Dresden, Germany.
    Cellular fibrous dermatofibroma is a rare variant of dermatofibroma/histiocytoma. We present a 61 years old female with a slow-growing, firm tumor on the sole of her right foot. The tumor was removed by slow Mohs surgery within 2 cm negative margin. Read More

    Plaque-Like Dermatofibroma With Satellitosis.
    Dermatol Surg 2017 Jan;43(1):139-142
    Penn State College of Medicine, Hershey, Pennsylvania Department of Pathology, West Virginia University, Morgantown, West Virginia Dermatology Associates of Lancaster, Hershey, Pennsylvania Department of Pathology, The Penn State Hershey Medical Center, Hershey, Pennsylvania Department of Dermatology, The Penn State Hershey Medical Center, Hershey, Pennsylvania.

    False Suggestion of Malignant Transformation of Benign Bone Tumor by 18F-FDG PET/CT: A Potential Pitfall.
    Clin Nucl Med 2016 Oct;41(10):774-5
    From the *Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung City; †China Medical University, Taichung City; ‡Department of Radiation Oncology, Changhua Show Chwan Memorial Hospital, Changhua County; §Department of Radiation Oncology, China Medical University Hospital, Taichung City; ∥Department of Radiology, China Medical University Hospital, Taichung City; ¶Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City; and **School of Medicine, China Medical University, Taichung City, Taiwan.
    A 68-year-old man underwent serial F-FDG PET/CT scan follow-up for lung cancer. Then 5.5 years after the initial F-FDG PET/CT scan, the presumed benign bone tumor in the left clavicle showed markedly increased FDG uptake during follow-up; in contrast, the Tc-MDP bone scan paradoxically exhibited no apparent interval change since last bone scan 5. Read More

    Solitary Encapsulated Neurofibroma Not Associated with Neurofibromatosis-1 Affecting Tongue in a 73-Year-Old Female.
    Case Rep Dent 2016 20;2016:3630153. Epub 2016 Jul 20.
    Department of Oral & Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences & Research, 157/F Nilgunj Road, Panihati, Kolkata 700114, India.
    Neurofibromas are benign tumors of nerve cell origin arising due to proliferation of Schwann cells and fibroblasts. They are usually asymptomatic and hence remain undiagnosed. They are commonly found on the skin and intraorally tongue is the most common site for their occurrence. Read More

    [Clinicopathologic analysis of extranodal Rosai-Dorfman disease of breast: a report of 12 cases].
    Zhonghua Bing Li Xue Za Zhi 2016 Aug;45(8):556-60
    Department of Pathology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China.
    Objective: To investigate the clinicopathologic features, diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease(RDD)of the breast.

    Methods: Twelve cases of extranodal RDD of the breast were analyzed using hematoxylin-eosin stain and immunohistochemical staining.The morphological features and immunophenotype were observed by light microscopy, accompanied with a review of the literature. Read More

    Benign Fibrous Histiocytoma of Mandible: A Case Report and Updated Review.
    J Clin Diagn Res 2016 Jun 1;10(6):ZD24-6. Epub 2016 Jun 1.
    Assistant Professor, Department of Oral Pathology and Microbiology, Government Dental College , Calicut, Kerela, India .
    Benign Fibrous Histiocytoma (BFH) is a well recognised tumour of the soft tissue, developing entirely within the subcutaneous tissue, the deep soft tissues or in the parenchymal organs. However, BFH of bones is poorly defined. It has been rarely reported in the bones with femur, tibia and pelvic bone being the most commonly affected bones. Read More

    Dermatofibrosarcoma protuberans post basal cell carcinoma excision: A case report.
    Int J Surg Case Rep 2016 29;26:146-9. Epub 2016 Jul 29.
    Texas Tech University Health Sciences Center, School of Medicine, Department of Surgery, 1400S, Coulter Street, Amarillo TX 79106, USA. Electronic address:
    Introduction: Dermatofibrosarcoma protuberans (DFSP) is a rare, malignant, soft tissue neoplasm of the dermis. Tumor recurrence is common following resection, and can be locally devastating if not identified in a timely manner. We report a unique case of this rare tumor. Read More

    Folliculotropic Cutaneous Metastases and Lymphangitis Carcinomatosa: When Cutaneous Metastases of Breast Carcinoma Are Mistaken for Cutaneous Infections.
    Acta Dermatovenerol Croat 2016 Jun;24(2):154-7
    Giovanni Paolino, MD, Viale del Policlinico, Rome, Italy;
    Dear Editor, Cutaneous metastases (CM) are detected in about 0.6-10.4% of patients with an internal malignancy (1-3). Read More

    Intra-abdominal fat. Part III. Neoplasms lesions of the adipose tissue.
    J Ultrason 2016 Jun 29;16(65):145-54. Epub 2016 Jun 29.
    Self-Education Ultrasound Study Group, Department of Genetics and Pathomorphology of the Pomeranian Medical University in Szczecin, Poland.
    This article focuses on various cancerous lesions that are found beyond organs in the intra-abdominal fat and can be visualized with ultrasonography. These lesions are divided into five groups. The first group includes primary benign tumors containing adipocytes, such as lipoma, lipoblastoma, hibernoma and other lesions with an adipose tissue component, such as myolipoma, angiomyolipoma, myelolipoma and teratoma. Read More

    Dermatofibroma simulating seborrheic keratosis dermoscopically.
    An Bras Dermatol 2016 May-Jun;91(3):354-6
    Universidade de Pernambuco (UPE) - Recife (PE), Brazil.
    Dermatofibroma is a frequent benign tumor of easy clinical diagnosis in most cases, but that can mimic other dermatoses. Dermoscopy may help to define the diagnosis and its classical pattern is a central white area, similar to a scar, surrounded by a discrete pigment network. However, dermoscopic findings are not always typical. Read More

    Subcutaneous Benign Fibrous Histiocytoma: Rare Presentation on Cheek-Case Report and Review of Literature.
    J Maxillofac Oral Surg 2016 Jul 5;15(Suppl 2):282-6. Epub 2015 Aug 5.
    Department of Oral and Maxillofacial Surgery, KLR Lenora Institute of Dental Sciences, Rajahmundry, India.
    Fibrous histiocytoma is a benign tumor of mesenchymal origin. The tumor frequently appears in sun exposed areas on skin and orbital tissues. The subcutaneous appearance of this tumor in deep soft tissues is rare. Read More

    Benign Spindle Cell Tumour of Mandible and Points of Modification in Reconstruction with Nonvascularised Iliac Crest Graft.
    J Maxillofac Oral Surg 2016 Jul 24;15(Suppl 2):262-5. Epub 2015 Mar 24.
    Oral and Maxillofacial Surgery, KMCT Dental College and Hospitals, Manassery P O, Mukkam, Calicut, 673602 India.
    Benign fibrous histiocytoma (BFH) is a rare spindle cell tumor occurring in the jaw. It is a benign lesion composed of spindle shaped fibroblasts arranged in a storiform pattern. Literature shows that there are less than hundred reported cases of BFH worldwide and only six reported cases in the mandible. Read More

    Conjunctival fibrous histiocytoma in an 8-year-old boy.
    J AAPOS 2016 Aug 7;20(4):368-70. Epub 2016 Jun 7.
    Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    An 8-year-old healthy boy underwent surgery for excision of a painless, enlarging vascularized conjunctival tumor. Histopathology disclosed a mass comprised of interweaving spindle cells and scattered histiocytes in a fibrous matrix, consistent with benign fibrous histiocytoma. This rare tumor can resemble several conditions, including scleritis/episcleritis, inflamed pterygium, juvenile xanthogranuloma, foreign body granuloma, solitary fibrous tumor, amelanotic melanoma, and squamous cell carcinoma. Read More

    [Primary cutaneous cribriform apocrine carcinoma : An underdiagnosed entity?].
    Hautarzt 2016 Sep;67(9):750-2
    Dermatopathologie Bodensee, Friedrichshafen, Deutschland.
    Primary cutaneous cribriform apocrine carcinoma is a distinctive but little known variant of cutaneous apocrine carcinoma with indolent biological behaviour. It should not be mistaken for a cutaneous metastasis of a visceral carcinoma, an adenoid cystic basal cell carcinoma or a primary cutaneous adenoid cystic carcinoma. Read More

    Malignant fibrous histiocytoma of maxillary sinus- a diagnostic challenge.
    Indian J Surg Oncol 2015 Sep 22;6(3):259-62. Epub 2015 Feb 22.
    Department of Pathology, Sir Ganga Ram Hospital, New delhi, India.
    Malignant fibrous histiocytoma (MFH) is a malignant mesenchymal tumor uncommonly seen in head and neck region and even rarer in maxillary sinus with less than thirty cases reported in literature. Microscopic diagnosis at this rare site may be challenging because of the spectrum of features, which frequently overlap with other benign and malignant tumors. We herein report a case of malignant fibrous histiocytoma of the maxillary sinus in a 40-year-old man who presented with epistaxis. Read More

    NF1 frameshift mutation (c.6520_6523delGAGA) association with nervous system tumors and bone abnormalities in a Chinese patient with neurofibromatosis type 1.
    Genet Mol Res 2016 Apr 7;15(2). Epub 2016 Apr 7.
    Department of Neurology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
    Neurofibromatosis type 1, also known as NF1 or von Recklinghausen's disease, is a common neurocutaneous syndrome that presents with multiple café-au-lait patches, skinfold freckling, dermatofibromas, neurofibromas, and Lisch nodules. The mutations of the gene NF1, encoding the protein neurofibromin, have been identified as the cause of this disease. Here, we report a clinical and molecular study of a Chinese patient with multiple café-au-lait skin freckles, dermatofibroma, central and peripheral nervous system tumors, and bone abnormalities attributed to NF1. Read More

    Angiomatoid fibrous histiocytoma: Clinicopathological spectrum of five cases, including EWSR1-CREB1 positive result in a single case.
    Indian J Pathol Microbiol 2016 Apr-Jun;59(2):148-52
    Department of Surgical Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India.
    Background: Angiomatoid fibrous histiocytoma (AFH) is an unusual soft tissue tumor (STT), characterized by recurrences, but rarely metastasis. Later, certain molecular signatures have been identified underlying this tumor, which at times, is either underdiagnosed as a benign vascular tumor, or over diagnosed as a high-grade pleomorphic sarcoma, including a malignant fibrous histiocytoma.

    Materials And Methods: Over a 14-year-period, five diagnosed cases of AFH were analyzed. Read More

    Immunohistochemical evaluation of p16 expression in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions.
    J Cutan Pathol 2016 Aug 6;43(8):671-8. Epub 2016 Jun 6.
    Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
    Background: Expression of p16 is frequently evaluated in melanocytic lesions. Expression of p16 in cutaneous histiocytic, fibrohistiocytic and undifferentiated lesions has not been well characterized.

    Methods: We evaluated p16 expression in a cohort of histiocytic (reticulohistiocytoma, Langerhans cell histiocytosis, xanthogranuloma, Rosai Dorfman disease and xanthoma), fibrohistiocytic (dermatofibroma, epithelioid fibrous histiocytoma and dermatofibrosarcoma protuberans) and undifferentiated (atypical fibroxanthoma and pleomorphic undifferentiated sarcoma) lesions. Read More

    Meyerson Phenomenon as a Component of Melanoma in situ.
    Acta Dermatovenerol Croat 2016 Apr;24(1):81-2
    Engin Sezer, MD, Acıbadem University School of Medicine, Department of Dermatology, Buyukdere Caddesi No: 40, Istanbul, Turkey;
    Meyerson phenomenon (MP) is characterized by a symmetrical area of erythema and scales encircling a central lesion, which is most commonly a banal melanocytic nevus. Herein, we describe an unusual case with MP representing an eczematized response to a melanoma in situ and review the literature covering this entity. A 56-year-old man presented with a 6-month history of a pruritic, pigmented lesion on the trunk. Read More

    "Pseudo-Circumscribed Palmar or Plantar Hypokeratosis (Pseudo-CPH)": a Histologic Pattern Secondary to Trauma; Further Characterization of a Known Entity.
    Am J Dermatopathol 2016 May;38(5):359-62
    *Dermatology and Advanced Skin Care, Ellicott City, MD; †Baldassano Dermatopathology, P.C., Blue Bell, PA; and ‡Drexel University College of Medicine, Philadelphia, PA.
    Circumscribed palmar or plantar hypokeratosis (CPH) is defined clinically as well-circumscribed areas of erythematous eroded skin mostly over thenar or hypothenar eminences of the palms and less commonly soles. Histologically, lesions demonstrate a characteristic abrupt drop-off in the cornified layer leading to broad areas of hypokeratosis. In the original description in 2002, Perez et al favored these lesions to be a distinctive epidermal malformation. Read More

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