6,453 results match your criteria Dermatofibroma
Dermatol Pract Concept 2018 Oct 31;8(4):337-339. Epub 2018 Oct 31.
Department of Pathology, Hospital Universitario de Móstoles, Madrid, Spain.
Australas J Dermatol 2018 Nov 26. Epub 2018 Nov 26.
Dermatology Department, Hospital General Universitario de Alicante, Alicante, Spain.
Background/objectives: The aim of this study was to evaluate the morphological findings of lipidised dermatofibromas under dermoscopic observation.
Methods: Dermoscopic examination of 13 cases of lipidised dermatofibromas was performed to evaluate specific dermoscopic criteria and patterns.
Results: The most frequently occurring dermoscopic features were as follows: (i) A yellowish homogenous pigmentation in all cases (100%); this pigmentation was total in 30. Read More
Appl Immunohistochem Mol Morphol 2018 Oct 24. Epub 2018 Oct 24.
Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, MA.
Intermediate tumors of the head and neck fall in the borderline category. They are clinically aggressive tumors with no malignant phenotyping. They are locally infiltrative and have high recurrence rate with less chances to metastasize. Read More
Am J Dermatopathol 2018 Oct 4. Epub 2018 Oct 4.
Laboratory Medicine, Department of Pathology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Epithelioid fibrous histiocytoma (EFH) is a rare lesion believed to arise from dermal microvascular unit fibroblasts and dendritic histiocytes. EFH has long been considered a morphologic variant of benign fibrous histiocytoma (dermatofibroma), with prominent epithelioid cytomorphology that can mimic both vascular and melanocytic neoplasms. The molecular basis for the relationship between EFH and benign fibrous histiocytoma has remained largely unknown, with some authors suggesting that EFH represents an entity that is biologically distinct from benign fibrous histiocytoma. Read More
J Cutan Pathol 2018 Oct 1. Epub 2018 Oct 1.
Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Cellular neurothekeoma is a benign cutaneous neoplasm that typically occurs on the head, neck, and upper body of young adults with a slight female predominance. It is a rare lesion to diagnose and multiple neurothekeomas in one patient are even more uncommon finding. We present a case of multiple neurothekeomas in a middle-aged woman with lower extremity involvement and summarize the current literature on multiple neurothekeoma patients. Read More
Int J Dermatol 2018 Sep 21. Epub 2018 Sep 21.
Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):700-705
Department of Pathology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
To study clinicopathologic features, diagnosis and differential diagnosis of myxoid variant of angiomatoid fibrous histiocytoma (AFH). Three cases of myxoid variant of AFHs were collected from First Affiliated Hospital of Nanjing Medical University during 2008 and 2017. EnVision method and fluorescence in situ hybridization(FISH) were used to detect immunophenotype and EWSR1 gene rearrangement, respectively. Read More
Orbit 2018 Sep 5:1-5. Epub 2018 Sep 5.
a Edward Harkness Eye Institute , Columbia University Medical Center , New York , New York , USA.
Purpose: Dermatofibromas are common cutaneous lesions, but rarely occur in the eyelid skin. The reason for the low incidence in the palpebral skin has not been elucidated. In this study, we analyze the histopathologic features of an illustrative case of dermatofibroma and review previously published cases to determine whether eyelid dermatofibroma develops differently from the prototypical dermatofibroma. Read More
Pediatr Dermatol 2018 Nov 31;35(6):e360-e362. Epub 2018 Aug 31.
Department of Dermatology, La Paz Hospital, Madrid, Spain.
A newborn boy presented with a progressively infiltrating and painful congenital ulcerated plaque on the back of his left foot. A partial excision was performed and histopathologic examination confirmed a diagnosis of a plexiform fibrohistiocytic tumor. This rare tumor usually appears in children and adolescents, with congenital presentations even more uncommon. Read More
Dermatol Online J 2018 Jun 15;24(6). Epub 2018 Jun 15.
University of Texas McGovern Medical School at Houston, Houston, Texas.
Dermatofibroma frequently presents as a red-brown nodule on the extremities of the middle aged. Atrophic dermatofibroma is a rare variant that has been most commonly described as an atrophic depressed, erythematous lesion in females. The correct diagnosis of atrophic dermatofibroma is often hindered by its infrequent presentation. Read More
Dermatol Surg 2018 Sep;44(9):1229-1231
Department of Dermatology, Columbia University Medical Center, New York, New York.
J Bone Oncol 2018 Sep 2;12:78-82. Epub 2018 Aug 2.
Department of Orthopedics, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, PR China.
Background: Bone benign fibrous histiocytoma (BFH) is an invasive primary bone tumor. When the local excision is not complete, the risk of recurrence is high, and hence, one-piece resection is necessary. The major challenge for clinicians is to reconstruct the bone after resection of the tumor. Read More
Dermatol Pract Concept 2018 Jul 31;8(3):224-226. Epub 2018 Jul 31.
Dermatology Department, Pontificia Universidad Católica de Chile, Santiago, Chile.
Ann Dermatol Venereol 2018 Oct 7;145(10):613-619. Epub 2018 Aug 7.
Cabinet de pathologie cutanée, 56, rue de la Roquette, 75011 Paris, France.
Background: Histiocytoma or dermatofibroma (DF) is a common benign skin tumour with several clinical and histopathological variants. Sebaceous induction overlying a dermatofibroma is rare and infrequently reported. Using a detailed clinical case, herein the semiological and dermoscopic features of this lesion are described and illustrated, and the differential diagnoses presented. Read More
J Cutan Pathol 2018 Dec 5;45(12):966-968. Epub 2018 Sep 5.
Department of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Indian Dermatol Online J 2018 Jul-Aug;9(4):265-267
Department of Pathology, SB University Training and Research Hospital, Antalya, Turkey.
Dermatofibromas are common lesions of the skin. Although they occur at any part of the body, they are most commonly observed on the lower legs of middle-aged women. The lesion comprises fibroblast-like cells, histiocytes, collagenous tissue, and blood vessels. Read More
J Cutan Pathol 2018 Oct 1;45(10):774-776. Epub 2018 Aug 1.
Department of Pathology, Stony Brook Medicine, Stony Brook, New York.
Aneurysmal benign fibrous histiocytomas are variants of dermatofibromas. These benign blood-filled lesions can mimic malignancies due to their rapid and recurrent growth. Our patient is a 42-year-old Caucasian female with a past medical history of morbid obesity, diabetes, and hypertension, who presented with a mass on her left shoulder for 5 years' duration. Read More
Medicine (Baltimore) 2018 Jun;97(26):e11099
The First Affiliated Hospital of Dalian Medical University-Radiology Department, Liaoning, Dalian, China.
Rationale: Sclerosing angiomatoid nodular transformation (SANT) is a rare case which usually occurs in spleen, but our case occurs in accessory spleen.
Patient Concerns: We reported a case of a 27 year old man who was identified with an isodense mass in the left abdominal cavity by ultrasonicphysical examination without symptoms. Blood routine and tumor markers (alpha fetal protein, carcinoembryonic antigen, CA19-9, CA125) were normal. Read More
Clin Case Rep 2018 Jun 6;6(6):1006-1009. Epub 2018 Apr 6.
Department of Dermatology Aksaray University Training and Research Hospital Aksaray 68200 Turkey.
We report a case of hemosiderotic dermatofibroma presenting as a brown-black-colored nodule with peripheral extensions, which mimics melanoma. Histopathology showed completely benign features with no atypia or mitosis. Nodular extensions of childhood dermatofibromas may be related to the growth of the child not necessarily pointing to a malignant process. Read More
Indian J Dermatol Venereol Leprol 2018 Jul-Aug;84(4):468-470
Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Am Acad Dermatol 2018 Nov 22;79(5):843-852. Epub 2018 May 22.
Department of Pathology, Seoul National University Boramae Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
Background: Little is known regarding oncoproteins other than platelet-derived growth factor subunit B in dermatofibrosarcoma protuberans (DFSP). Moreover, the risk factors for worse prognosis are controversial.
Objective: We sought to determine the clinicopathologic features and key factors for adverse outcome in DFSP, including the implication of expression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), signal transducer and activator of transcription 3 (STAT3), extracellular signal regulated kinase (ERK), cyclin D1, and programmed death ligand 1 (PD-L1). Read More
Pathol Res Pract 2018 Jun 11;214(6):821-825. Epub 2018 May 11.
Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:
Microphthalmia-associated transcription factor (MiTF) is used as a marker of melanocytic differentiation. However, MiTF immunoexpression has also been observed in histiocytes, macrophages, smooth muscle cells and fibroblasts, which raise the concern of fibrohistiocytic (FH) lesions being misdiagnosed as melanoma based on MiTF immunoreactivity. MiTF has been known to be positive in FH tumors, but this is the first study evaluating ninety-three fibrohistiocytic neoplasms to understand and delineate the staining pattern of MiTF in these tumors. Read More
Cutis 2018 Apr;101(4):E9-E11
Dermatology Department, Complejo Asistencial Universitario de Palencia, Spain.
Cutis 2018 Apr;101(4):E6-E8
Section of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
J Cutan Pathol 2018 Aug 8;45(8):623-628. Epub 2018 Jun 8.
Department of Dermatology, Kurume University School of Medicine, Kurume, Japan.
Adenodermatofibroma is a newly recognized variant of dermatofibroma characterized by dense proliferation of fibroblasts and histiocytes admixed with dilated glandular structures showing apocrine secretion. Only five cases of adenodermatofibroma have been reported to date. We report an additional case of adenodermatofibroma on the back of a 67-year-old female. Read More
Diagn Pathol 2018 May 10;13(1):28. Epub 2018 May 10.
Pathology Project for Molecular Targets, the Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Background: Epithelioid cell histiocytoma (ECH), which is also known as epithelioid benign fibrous histiocytoma, has been classified as a rare variant of fibrous histiocytoma (FH). However, the recent detection of ALK protein expression and/or ALK gene rearrangement in ECH suggests that it might be biologically different from conventional FH.
Case Presentation: A 27-year-old male presented with nodule on his left foot, which had been present for 5 years. Read More
J Cutan Pathol 2018 Aug 12;45(8):619-622. Epub 2018 Jun 12.
David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Cellular neurothekeomas (CNTs) are rare, benign cutaneous tumors that arise primarily on the head and neck, with a slight female predominance. CNTs with atypical features have been described, including those with an infiltrative growth pattern. Although CNTs with atypical features are benign, recognition of this entity can pose diagnostic challenges. Read More
An Bras Dermatol 2018 Mar;93(2):291-293
Hospital de Santarém EPE, Santarém, Portugal.
Multinucleate cell angiohistiocytoma is a rare idiopathic benign fibrohistiocytic and vascular proliferation usually presenting as multiple asymptomatic papules, red to violaceous in colour, primarily located on the extremities of middle-aged females. This entity is probably underdiagnosed due to the lack of recognition by clinicians and pathologists. We describe a patient with a multinucleate cell angiohistiocytoma of the face, a less frequent localization, in order to increase awareness of this entity and elucidate its clinical, histopathological, and immunohistochemistry features. Read More
Appl Immunohistochem Mol Morphol 2018 Apr 7. Epub 2018 Apr 7.
Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More
Arch Craniofac Surg 2018 Mar 20;19(1):72-74. Epub 2018 Mar 20.
Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Dermatofibromas most commonly occur on limbs and rarely occur on the face. Dermatofibroma occurring on the face is associated with unusual clinicopathologic features and a more aggressive clinical course in comparison to typical cases. Additionally, the most common subtype found in previous studies was benign fibrous histiocytoma, with the keloid type being very rare (about 1% of reported cases). Read More
Dermatology 2017 22;233(6):482-488. Epub 2018 Mar 22.
Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Background: Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions.
Objective: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benign- or malignant-looking appearance. Read More
Cutis 2018 Jan;101(1):E8-E9
Department of Dermatology, Mayo Clinic, Scottsdale, Arizona, USA.
J Cancer Res Ther 2018 Jan-Mar;14(2):444-446
Department of General Surgery, KS Hegde Medical Academy, KS Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
Giant cells in soft tissue (ST) tumors are rare, pose great challenges to treating clinicians, and diagnosing pathologists. Common lesion with giant cells includes benign conditions such as nodular fasciitis to highly malignant lesions such as giant cell variant of malignant fibrous histiocytoma and extraskeletal osteosarcoma. Giant cell tumors of ST, extension of bony lesion to the ST are also rare possibilities. Read More
Clin Exp Dermatol 2018 Jul 6;43(5):627-629. Epub 2018 Mar 6.
Department of Dermatology, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
Ophthalmic Plast Reconstr Surg 2018 May/Jun;34(3):e90-e91
Department of Ophthalmology, San Antonio Military Medical Center, San Antonio, Texas, U.S.A.
Fibrous histiocytoma is a soft tissue tumor with cells resembling both fibroblasts and histiocytes. Occasionally in the orbit, they rarely arise in the lacrimal sac. Similar to prior cases described, the patient presented with symptoms of epiphora and a slowly enlarging mass inferior to the right medial canthus. Read More
Pathology 2018 Apr 1;50(3):358-361. Epub 2018 Mar 1.
Biomedical Research Institute INCLIVA, Valencia, Spain; Department of Pathology, Hospital Clínico Universitario de Valencia, Valencia, Spain; University of Valencia, Valencia, Spain. Electronic address:
Int J Surg Case Rep 2018 15;44:29-32. Epub 2018 Feb 15.
Sri Ramachandra Medical College, Porur, Chennai - 600116, Tamil Nadu, India. Electronic address:
Introduction: Nodular Fasciitis, also known as infiltrative or pseudosarcomatous fasciitis, is a benign soft tissue tumour of fibroblastic/myofibroblastic differentiation, that was first described in 1955 by Konwaler et al. PRESENTATION OF CASE: This is a case report of a 27-year old male with complaints of a swelling in the right axilla for 2 and ½ years measuring 12 cm × 10 cm. Chest X-Ray was normal. Read More
Dermatol Online J 2017 Sep 22;23(9). Epub 2017 Sep 22.
Department of Internal Medicine, Scripps Mercy Hospital, San Diego, California.
Dermatofibromas are benign, fibrohistiocytic, dermal tumors. Solitary dermatofibromas may be incidental findings, whereas multiple dermatofibromas may be associated with systemic conditions or previous therapies. Two women and one man with multiple dermatofibromas and an associated systemic condition, immunosuppression, or both, are described. Read More
Virchows Arch 2018 Mar 21;472(3):469-476. Epub 2018 Feb 21.
Département de Biopathologie, Centre Leon Bérard, Lyon, France.
The current classification of melanocytic tumors includes clinical, pathological, and molecular data. A subset of lesions remains difficult to classify according to these complex multilayer schemes. We report two cases of deeply infiltrating melanomas with a sclerosing background. Read More
J Surg Orthop Adv 2017 WINTER;26(4):266-270
ProScan Imaging Education Foundation, Cincinnati, Ohio; Department of Radiology, University of Louisville, Louisville, Kentucky; Department of Radiology, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri; Department of Orthopedic Surgery, University of Cincinnati, Cincinnati, Ohio; Saint George Children's Hospital, Puerto Rico; and World Care Clinical Research, Boston, Massachusetts.
Plantar fibromatosis, also known as Ledderhose's disease, is a benign fibroblastic disorder of plantar aponeurosis, more specifically the medial side of the foot arch. Magnetic resonance imaging (MRI) has an important role in the diagnosis, staging, and determining the deep extension found in advanced, aggressive forms of plantar fibromatosis, thereby guiding appropriate clinical and surgical management. This case report aims to provide radiologists and clinicians with simple guidelines for the differential diagnosis of the fibroblastic and fibrohistiocytic soft tissue tumors of the foot with the emphasis on the MRI findings. Read More
Pathol Int 2018 Mar 16;68(3):196-201. Epub 2018 Feb 16.
Department of Pathology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Sclerosing pneumocytoma is a rare tumor of the lung, commonly affecting middle-aged women, and is mostly isolated. Although this tumor is thought to be derived from primitive respiratory epithelial cells, the characteristics of the precursor cells are still unknown. A 19-year-old woman presented with multiple nodules in the right lung. Read More
Vet Pathol 2018 07 14;55(4):517-520. Epub 2018 Feb 14.
2 Department of Pathology and Athens Veterinary Diagnostic Laboratory, University of Georgia College of Veterinary Medicine, Athens, GA, USA.
Multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM1/IRF-4) immunohistochemistry (IHC) is mainly used for diagnostic confirmation of plasma cell tumors (PCTs) in dogs and cats. This article describes MUM1/IRF-4 IHC expression in 20 cases of canine cutaneous histiocytoma (CH) and compares it with 10 cutaneous or mucocutaneous PCTs and 5 cutaneous histiocytic sarcomas (HSs) submitted to the same IHC protocol. All histiocytomas had strong nuclear and variable cytoplasmic immunolabeling for MUM1/IRF-4, whereas all PCTs had strong nuclear and moderate cytoplasmic immunolabeling for MUM1/IRF-4. Read More
Nucl Med Rev Cent East Eur 2018 ;21(1):53
Apollo Gleneagles Hospital, 58 Canal Circular Road, 700054 Kolkata, India.
Sclerosing Angiomatoid Nodular Transformation (SANT) is a rare benign vascular tumor of spleen. It consists of multiple angiomatoid nodules surrounded by dense fibrous tissue that often coalesces centrally to form a scar, which is considered to be a characteristic feature. These are usually asymptomatic and incidentally detected on imaging for other underlying pathology. Read More
J Invest Dermatol 2018 Jul 8;138(7):1529-1538. Epub 2018 Feb 8.
Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. Electronic address:
We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model; Microsoft Research Asia, Beijing, China) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (19,398 images in total). The trained model was validated with the testing portion of the Asan, Hallym and Edinburgh datasets. Read More
Zhongguo Gu Shang 2017 Jul;30(7):647-650
Department of Bone Joint Surgery, the First Hospital of Jilin University, Changchun 130021, Jilin, China;
Objective: To evaluate the clinical feasibility of particle impaction bone graft and plate internal fixation for the treatment of proximal femoral bone tumors or tumor disease.
Methods: From January 2013 to January 2016 a total of 26 cases of the proximal femur bone tumors or tumor lesions, neither pathological fracture, were retrospectively analyzed, including 12 males and 14 females with an average age of 34.2 years old ranging from 8 to 62 years old. Read More
Acta Derm Venereol 2018 Apr;98(5):540-541
Department of Dermatology, Hospital Clínico San Borja Arriarán, Santa Rosa 1234, Santiago, Chile.
JAAD Case Rep 2018 Mar 16;4(2):155-158. Epub 2018 Jan 16.
Department of Pediatrics and Medicine, Division of Dermatology, Dell Medical School at the University of Texas at Austin, Austin, Texas.
Int J Dermatol 2018 Jun 31;57(6):707-712. Epub 2018 Jan 31.
Departamento de Patologia da Faculdade de Medicina da, Universidade de São Paulo, Sao Paulo, Brazil.
Background: Histoid leprosy (HL) is a rare form of lepromatous leprosy, characterized by hyperchromic indurated nodules above normal skin. Its main histopathological aspect is spindle cells. Because it may simulate other aspects, such as dermatofibroma and neurofibroma, histoid leprosy poses itself as a diagnostic challenge. Read More
Int Arch Otorhinolaryngol 2018 Jan 2;22(1):94-102. Epub 2017 May 2.
Division of Dermatology, Creighton University School of Medicine, Omaha, Nebraska, United States.
Benign fibrous histiocytomas are common lesions of the skin that rarely affect the tongue. Such cases are available in the literature exclusively as case reports. Similarly, malignant fibrous histiocytoma, now classified as undifferentiated pleomorphic sarcoma, is exceedingly rare in the tongue and not fully understood. Read More
Skin Res Technol 2018 May 24;24(2):285-293. Epub 2018 Jan 24.
Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Background: Seborrheic keratoses (SebK) with atypical dermoscopy presentation are increasingly reported. These lesions do not exhibit typical dermoscopy features of SebK and sometimes mimic melanoma, thus complicating the differential diagnosis. Reflectance confocal microscopy (RCM) is a non-invasive tool, which allows an in vivo imaging of the skin. Read More