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    Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.
    Appl Immunohistochem Mol Morphol 2018 Apr 7. Epub 2018 Apr 7.
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
    Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More

    Rare experience of keloidal dermatofibroma of forehead.
    Arch Craniofac Surg 2018 Mar 20;19(1):72-74. Epub 2018 Mar 20.
    Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Dermatofibromas most commonly occur on limbs and rarely occur on the face. Dermatofibroma occurring on the face is associated with unusual clinicopathologic features and a more aggressive clinical course in comparison to typical cases. Additionally, the most common subtype found in previous studies was benign fibrous histiocytoma, with the keloid type being very rare (about 1% of reported cases). Read More

    Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!
    Dermatology 2017 22;233(6):482-488. Epub 2018 Mar 22.
    Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
    Background: Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions.

    Objective: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benign- or malignant-looking appearance. Read More

    Giant cells in soft tissue tumors! Is it a clue to diagnosis or cytologists mystery??? An unusual case report.
    J Cancer Res Ther 2018 Jan-Mar;14(2):444-446
    Department of General Surgery, KS Hegde Medical Academy, KS Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
    Giant cells in soft tissue (ST) tumors are rare, pose great challenges to treating clinicians, and diagnosing pathologists. Common lesion with giant cells includes benign conditions such as nodular fasciitis to highly malignant lesions such as giant cell variant of malignant fibrous histiocytoma and extraskeletal osteosarcoma. Giant cell tumors of ST, extension of bony lesion to the ST are also rare possibilities. Read More

    Fibrous Histiocytoma of the Lacrimal Sac in an 11-Year-Old Male.
    Ophthal Plast Reconstr Surg 2018 Feb 27. Epub 2018 Feb 27.
    Department of Ophthalmology, San Antonio Military Medical Center, San Antonio, Texas, U.S.A.
    Fibrous histiocytoma is a soft tissue tumor with cells resembling both fibroblasts and histiocytes. Occasionally in the orbit, they rarely arise in the lacrimal sac. Similar to prior cases described, the patient presented with symptoms of epiphora and a slowly enlarging mass inferior to the right medial canthus. Read More

    Nodular fasciitis mimicking a soft tissue sarcoma - A case report.
    Int J Surg Case Rep 2018 15;44:29-32. Epub 2018 Feb 15.
    Sri Ramachandra Medical College, Porur, Chennai - 600116, Tamil Nadu, India. Electronic address:
    Introduction: Nodular Fasciitis, also known as infiltrative or pseudosarcomatous fasciitis, is a benign soft tissue tumour of fibroblastic/myofibroblastic differentiation, that was first described in 1955 by Konwaler et al. PRESENTATION OF CASE: This is a case report of a 27-year old male with complaints of a swelling in the right axilla for 2 and ½ years measuring 12 cm × 10 cm. Chest X-Ray was normal. Read More

    Unclassified sclerosing malignant melanomas with AKAP9-BRAF gene fusion: a report of two cases and review of BRAF fusions in melanocytic tumors.
    Virchows Arch 2018 Mar 21;472(3):469-476. Epub 2018 Feb 21.
    Département de Biopathologie, Centre Leon Bérard, Lyon, France.
    The current classification of melanocytic tumors includes clinical, pathological, and molecular data. A subset of lesions remains difficult to classify according to these complex multilayer schemes. We report two cases of deeply infiltrating melanomas with a sclerosing background. Read More

    Classification of the Clinical Images for Benign and Malignant Cutaneous Tumors Using a Deep Learning Algorithm.
    J Invest Dermatol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. Electronic address:
    We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model; Microsoft Research Asia, Beijing, China) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (19,398 images in total). The trained model was validated with the testing portion of the Asan, Hallym and Edinburgh datasets. Read More

    [Particle impaction bone graft and plate internal fixation for the treatment of proximal femoral bone tumor or tumor lesion].
    Zhongguo Gu Shang 2017 Jul;30(7):647-650
    Department of Bone Joint Surgery, the First Hospital of Jilin University, Changchun 130021, Jilin, China;
    Objective: To evaluate the clinical feasibility of particle impaction bone graft and plate internal fixation for the treatment of proximal femoral bone tumors or tumor disease.

    Methods: From January 2013 to January 2016 a total of 26 cases of the proximal femur bone tumors or tumor lesions, neither pathological fracture, were retrospectively analyzed, including 12 males and 14 females with an average age of 34.2 years old ranging from 8 to 62 years old. Read More

    Histoid leprosy: clinical and histopathological analysis of patients in follow-up in University Clinical Hospital of endemic country.
    Int J Dermatol 2018 Jan 31. Epub 2018 Jan 31.
    Departamento de Patologia da Faculdade de Medicina da, Universidade de São Paulo, Sao Paulo, Brazil.
    Background: Histoid leprosy (HL) is a rare form of lepromatous leprosy, characterized by hyperchromic indurated nodules above normal skin. Its main histopathological aspect is spindle cells. Because it may simulate other aspects, such as dermatofibroma and neurofibroma, histoid leprosy poses itself as a diagnostic challenge. Read More

    Clinical Features and Treatment of Fibrous Histiocytomas of the Tongue: A Systematic Review.
    Int Arch Otorhinolaryngol 2018 Jan 2;22(1):94-102. Epub 2017 May 2.
    Division of Dermatology, Creighton University School of Medicine, Omaha, Nebraska, United States.
     Benign fibrous histiocytomas are common lesions of the skin that rarely affect the tongue. Such cases are available in the literature exclusively as case reports. Similarly, malignant fibrous histiocytoma, now classified as undifferentiated pleomorphic sarcoma, is exceedingly rare in the tongue and not fully understood. Read More

    Seborrheic keratoses mimicking melanoma unveiled by in vivo reflectance confocal microscopy.
    Skin Res Technol 2018 May 24;24(2):285-293. Epub 2018 Jan 24.
    Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
    Background: Seborrheic keratoses (SebK) with atypical dermoscopy presentation are increasingly reported. These lesions do not exhibit typical dermoscopy features of SebK and sometimes mimic melanoma, thus complicating the differential diagnosis. Reflectance confocal microscopy (RCM) is a non-invasive tool, which allows an in vivo imaging of the skin. Read More

    The limitations of dermoscopy: false-positive and false-negative tumours.
    J Eur Acad Dermatol Venereol 2018 Jan 5. Epub 2018 Jan 5.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. Read More

    Fluorescence microscopy for the evaluation of elastic tissue patterns within fibrous proliferations of the skin on hematoxylin-eosin-stained slides.
    J Am Acad Dermatol 2018 Jan 5. Epub 2018 Jan 5.
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC. Electronic address:
    Background: Diagnosis of fibrous tumors can be challenging and expensive due to the use of special stains.

    Objective: Determine the usefulness of fluorescence microscopy in the evaluation of elastic pattern on H&E stained slides.

    Methods: A total of 228 slides were evaluated by fluorescence microscopy for elastic tissue patterns and sensitivity and specificity determined for relevant comparisons. Read More

    Subperiosteal fibroma of the orbit.
    Orbit 2018 Jan 5:1-3. Epub 2018 Jan 5.
    a Department of Ophthalmology, Bascom Palmer Eye Institute , University of Miami Miller School of Medicine , Miami , Florida , USA.
    Fibromas are benign, well-circumscribed tumors that are characterized as spindle-cell lesions with interlacing fibrous stroma. Here, we describe the clinical presentation, management, and outcome of a patient with an orbital fibroma. To our knowledge, this is the second case report of a biopsy-proven subperiosteal orbital fibroma to date. Read More

    Histopathological diagnoses in soft tissue tumours: an experience from a tertiary centre in Malaysia.
    Malays J Pathol 2017 Dec;39(3):209-216
    Universiti Kebangsaan Malaysia Medical Centre, Pathology Department, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia.
    Soft tissue tumours are a group of remarkably diverse neoplasms that frequently pose significant diagnostic challenges to general pathologists. This study aimed to compare the agreement of histopathological diagnoses between general pathologists from various referral institutes and the referred soft tissue pathologist in a tertiary centre. The common discrepancies and their causes are also presented here. Read More

    Plaque-like Myofibroblastic Tumor: A Series of 2 Cases of This Unusual Dermal Tumor Which Occurs in Infancy and Early Childhood.
    Pediatr Dev Pathol 2017 Jan 1:1093526617746807. Epub 2017 Jan 1.
    1 Department of Cellular Pathology, St George's Hospitals, London, UK.
    Plaque-like myofibroblastic tumor is a rare dermal spindle cell tumor which occurs in infancy or childhood within the first 4 years of life. The tumor is often pruritic and mostly presents on the lower back. We describe 2 cases with characteristic clinical and histological features of this entity, thus adding to the 10 cases which have so far been reported. Read More

    Unusual Uptake of 131I in a Cutaneous Benign Fibrous Histiocytoma in a Patient With Thyroid Cancer.
    Clin Nucl Med 2018 Jan;43(1):e31-e32
    From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, People's Republic of China.
    A 52-year-old man with papillary thyroid cancer underwent total thyroidectomy and subsequent I remnant ablation. The postablation whole-body radioiodine scanning showed an unexpected focus on the upper right arm. SPECT/CT found that the abnormal focus of radioactivity was from body surface. Read More

    [Soft tissue tumors : Epidemiology, classification and staging].
    Radiologe 2017 Nov;57(11):973-986
    Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum des Saarlandes, Kirrbergerstraße, 66424, Homburg/Saar, Deutschland.
    Benign, intermediate and malignant soft tissue tumors can be differentiated histologically. Furthermore, the tumors can be subdivided according to their linear differentiation. In the new World Health Organization (WHO) classification of soft tissue tumors from 2013 changes have been made relating to the allocation of known entities, e. Read More

    Histologic Mimics of Basal Cell Carcinoma.
    Arch Pathol Lab Med 2017 Nov;141(11):1490-1502
    From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
    Context: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Read More

    "Chondroblastoma-like" epithelioid fibrous histiocytoma: A previously undescribed and potentially confusing variant.
    J Cutan Pathol 2018 Feb 10;45(2):99-103. Epub 2017 Dec 10.
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
    Background: Epithelioid benign fibrous histiocytoma has been considered a variant of fibrous histiocytoma, but is now considered a distinct entity, typically showing ALK expression. Most show typical morphological features, including an epidermal collarette and large, bland, epithelioid cells. We have recently encountered 2 examples showing an unusual pattern of pericellular calcification, a previously unreported finding. Read More

    Induction of Desmoplastic Trichoepithelioma in a Dermatofibroma.
    Am J Dermatopathol 2017 Oct 2. Epub 2017 Oct 2.
    *Dermatology Department, "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania; and †Dermatopathology Laboratory, Dermatologikum, Hamburg, Germany.
    Induction of follicular germinative structures above a dermatofibroma (DF) is a common finding. Rarely, induction of a trichoblastoma in a DF has been observed. Here, we report the case of a desmoplastic trichoepithelioma induced by a DF. Read More

    Cholesterotic Fibrous Histiocytoma in a Patient with Metabolic Syndrome.
    Case Rep Dermatol 2017 May-Aug;9(2):136-140. Epub 2017 Aug 17.
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Among the many variants of dermatofibroma, dermatofibroma with cholesterol cleft (cholesterotic fibrous histiocytoma) is extremely rare. Here, we describe the case of a 50-year-old male patient with a cholesterotic fibrous histiocytoma on his left lower leg. He presented with a hyperkeratotic nodule 6 mm in diameter with a brown surface on the extensor surface of his left lower leg. Read More

    Pleomorphic Hyalinizing Angiectatic Tumour: A Rare Case Report and Discussion of Differential Diagnosis.
    J Clin Diagn Res 2017 Aug 1;11(8):ED15-ED16. Epub 2017 Aug 1.
    Postgraduate Student, Department of Pathology, BLDEU's Shri B.M. Patil Medical College, Hospital and Research Centre, Vijayapur, Karnataka, India.
    Pleomorphic Hyalinizing Angiectatic Tumour (PHAT) is one of the rare soft tissue tumour which is non-metastasizing. The origin of this tumour is yet uncertain. It occurs in adults as a slow growing subcutaneous mass mimicking clinically and histologically to various benign and malignant soft tissue tumours such as schwannoma, haemangioma and malignant fibrous histiocytoma. Read More

    Wade's histoid leprosy in a 14-year-old teenage boy.
    Rev Soc Bras Med Trop 2017 Jul-Aug;50(4):562-564
    Serviço de Dermatologia, Hospital Universitário de Brasília, Brasília, DF, Brasil.
    Wade's histoid leprosy (HL) is a rare variant of multibacillary leprosy, with characteristic clinical, immunologic, histopathologic, and bacteriologic features. It is associated with resistance to sulfa drugs or polychemotherapy and is rarely observed in patients who have not undergone prior treatment. Clinically, HL resembles keloid or dermatofibroma. Read More

    [A pink nodule on the face].
    Pan Afr Med J 2017 18;27:205. Epub 2017 Jul 18.
    Service de Dermatologie, Centre Hospitalier Universitaire Ibn Sina, Rabat, Maroc.
    We report the case of a 32-year old female patient, with no notable medical history, requiring dermatology consultation for evaluation of a nodule on her right cheek which had evolved over the past 10 years. Clinical examination showed a reddish dermal-based nodule with a smooth surface. The lesion measured 1cm in diameter and was located at the level of the right cheek (A). Read More

    Plaque-Like Myofibroblastic Tumor: Report of 4 Cases.
    Am J Dermatopathol 2017 Oct;39(10):767-772
    *Cabinet de Dermatopathologie, Paris, France;†Dermatopathologie Hôpital Necker Enfants Malades;‡Dermatologie CHU Reims, Reims, France;§Biopathologie CHU Reims;‖Dermatopathologie CHU Rennes, Rennes, France;¶Dermatologie Hôpital Necker Enfants Malades, Paris, France; and**Cabinet de Dermatologie Torcy.
    Plaque-like myofibroblastic tumor of infancy was first characterized in 2007 by Clarke et al. In the first 2 cases described, large plaque-like tumors presented in the first 3 months of life exhibited microscopic features consistent with dermatofibroma but with immunohistochemical features of myofibroblastic lineage. In 2013, Marqueling et al reported 3 additional cases, 2 of which presented in early childhood, prompting the authors to recommend that the name of this condition be shortened to plaque-like myofibroblastic tumor. Read More

    Beyond classic dermoscopic patterns of dermatofibromas: a prospective research study.
    J Med Case Rep 2017 Sep 20;11(1):266. Epub 2017 Sep 20.
    Department of Dermatology, University Hospital Hassan II, Fez, Morocco.
    Background: The usual stereotypical dermoscopic pattern associated with dermatofibromas is a pigment network and central white patch. However, this pattern may be difficult to diagnose in some variant cases. We aimed to describe dermoscopic patterns of dermatofibroma according to its histopathological subtypes, with special emphasis on new and rare dermoscopic features. Read More

    Benign Fibrous Histiocytoma: An Uncommon Presentation.
    J Clin Diagn Res 2017 Jul 1;11(7):ED08-ED09. Epub 2017 Jul 1.
    Professor and Head, Department of Pathology, NRS Medical College and Hospital, Kolkata, West Bengal, India.
    Intracranial fibrous histiocytomas are rare; Benign Fibrous Histiocytoma (BFH) being uncommon than its malignant counterpart. BFH comprises fibroblasts and histiocytes without any nuclear pleomorphism or atypia. We present a case of a 42-year-old male who had swelling over the occipital region for the past five years, which progressively increased in size. Read More

    The Role of CD34 and D2-40 in the Differentiation of Dermatofibroma and Dermatofibrosarcoma Protuberans.
    Turk Patoloji Derg 2017 ;1(1):223-227
    Department of Pathology, Antalya Training and Research Hospital, Antalya, Turkey.
    Objective: Dermatofibroma (DF) is a benign fibrohistiocytic tumor whereas dermatofibrosarcoma protuberans (DFSP) has intermediate malignant potential. CD34 is the most commonly used antibody in differentiating these tumors. Various studies have stated the rates of D2-40 expression as 0-50% in DFSPs and 86-100% in DFs. Read More

    [Clinical and pathologic features of extrapleural sarcomatoid mesothelioma].
    Zhonghua Bing Li Xue Za Zhi 2017 Aug;46(8):559-564
    Department of Pathology, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
    To investigate the morphological features, diagnosis and differential diagnosis of extrapleural sarcomatoid malignant mesothelioma (SMM). Six cases of extrapleural SMM were evaluated for their clinical, histological, immunohistochemical features, and prognosis. Patients included 3 men and 3 women, with a median age of 60 years (range 41-75 years). Read More

    Fibrohistiocytic Tumors.
    Clin Lab Med 2017 Sep 15;37(3):603-631. Epub 2017 Jun 15.
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Hilton 11, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address:
    Fibrohistiocytic tumors are a diverse group of reactive and neoplastic lesions including xanthoma, fibrous histiocytoma and its variants, solitary xanthogranuloma, dermatofibrosarcoma protuberans, and atypical fibroxanthoma. This article reviews some of the more commonly encountered fibrohistiocytic tumors with an emphasis on clinical presentation, macroscopic and histologic characteristics, molecular/cytogenetic findings where applicable, and differential diagnoses. Read More

    Dermatofibroma: sonographic findings and pathologic correlation.
    Acta Radiol 2018 Apr 9;59(4):454-459. Epub 2017 Aug 9.
    3 Department of Dermatology, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
    Background Ultrasound has been increasingly used for the evaluation of superficial soft tissue lesions. Dermatofibroma is one of the most common dermal lesions. Experiences in ultrasound examinations of dermatofibromas have been accumulated. Read More

    Aneurysmal Variant of Fibrous Histiocytoma- A Rare Entity Known for Recurrence.
    J Clin Diagn Res 2017 Jun 1;11(6):ED08-ED09. Epub 2017 Jun 1.
    Associate Professor, Department of General Surgery, Pondicherry Institute of Medical Sciences, Pondicherry University, Puducherry, India.
    Aneurysmal Fibrous Histiocytoma (AFH) is a distinct and a rare clinicopathological variant of Cutaneous Fibrous Histiocytoma (CFH). It differs from the usual benign fibrous histiocytoma clinically and morphologically with high rate of recurrence. Here, we report a case of AFH with history of recurrence which presented as a polypoid swelling and showed vascular spaces with no endothelial lining which was proved negative by CD34 immunostaining. Read More

    Proximal epithelioid sarcomatous dedifferentiation in secondary chondrosarcoma in a known case of multiple osteochondromatosis.
    J Lab Physicians 2017 Jul-Sep;9(3):214-216
    Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Osteochondroma is the most common benign bone tumor. Approximately 15% of osteochondromas occur as multiple lesions. Multiple osteochondromatosis has a higher risk of developing chondrosarcomas, which are of low grade with good prognosis. Read More

    Fibroblastic connective tissue nevus: Clinicopathological and immunohistochemical study of 14 cases.
    J Cutan Pathol 2017 Oct 19;44(10):827-834. Epub 2017 Jul 19.
    Dermopathologie Bodensee, Friedrichshafen, Germany.
    Background: We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labeled as fibroblastic connective tissue nevus (FCTN).

    Methods And Results: Total of 8 patients were male and 5 were female, ranging in age from 1 to 56 years. Lesions appeared as isolated nodules or plaques on the trunk (7 cases), the limbs (4 cases) and the neck (2 cases). Read More

    18F-FDG Uptake in Benign Fibrous Histiocytoma of Adrenal Gland: A Potential Pitfall.
    Clin Nucl Med 2017 Aug;42(8):622-623
    From the *Nuclear Medicine Centre, and †Cancer Centre, Sunway Medical Centre, Selangor, Malaysia.
    A 47-year-old man with newly diagnosed nasopharyngeal carcinoma underwent staging F-FDG PET/CT. Apart from showing increased FDG uptake in the primary site and locoregional nodal and liver metastases, an unusual site of intense FDG focus was demonstrated in the left adrenal gland. He underwent CT-guided biopsy, and the histopathologic diagnosis was benign fibrous histiocytoma. Read More

    Phosphohistone-H3 and Ki67: Useful Markers in Differentiating Dermatofibroma From Dermatofibrosarcoma Protuberans and Atypical Fibrohistiocytic Lesions.
    Am J Dermatopathol 2017 Jul;39(7):504-507
    *Department of Pathology, Baylor University Medical Center, Dallas, TX; †Department of Pathology, Pathologist Biomedical Laboratories, Dallas, TX; ‡Department of Pathology, UF Health, Jacksonville, Jacksonville, FL; §Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX; and ¶Department of Pathology, MD Anderson Cancer Center, Houston, TX.
    Dermatofibromas (DF) are common, benign, skin tumors, usually easily differentiated from dermatofibrosarcoma protuberans (DFSP) by the presence of a relative low cellularity, lesser degree of infiltration of subcutaneous tissue, and immunohistochemical pattern (eg, FXIIIa in DF and CD34 in DFSP). Atypical fibrohistiocytic lesions (AFL) have features intermediate to DF and DFSP (trunk location, storiform pattern, infiltration of the subcutaneous tissue, and focal expression of both CD34 and Factor XIIIa). It is unclear if mitotic counts/degree of proliferation is helpful to distinguish DF from DFSP. Read More

    Cutaneous malignancies simulating seborrheic keratoses: An underappreciated phenomenon?
    J Cutan Pathol 2017 Sep 2;44(9):747-748. Epub 2017 Jul 2.
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.
    Background: Seborrheic keratosis (SK), a common and benign entity, is generally diagnosed clinically without the need for a biopsy. Given their variable appearance, SK may mimic cancer clinically and require biopsy for clinically equivocal cases. A clinician may also choose to perform biopsies on SK based on other circumstances, such as cosmetic reasons or SK being in an inconvenient and irritative location. Read More

    Xanthomatous Posttraumatic Fibro-Osseous Lesion of the Rib: A Rare and Underrecognized Entity. Case Report and Literature Review.
    Int J Surg Pathol 2017 Oct 4;25(7):640-643. Epub 2017 Jun 4.
    1 Bichat Hospital, AP-HP, Paris, France.
    Posttraumatic fibro-osseous lesion (PTFOL) is a rare lesion that typically affects the ribs and is probably a posttraumatic reactive process. Because PTFOL is often misdiagnosed as fibrous dysplasia, osteoid osteoma, benign fibrous histiocytoma or rib metastases, chest wall resection, leading to a significant morbidity, is the main treatment modality. We report the case of a 30-year-old male patient with no history of previous trauma presenting with chest pain. Read More

    The Immunological Roles of Periostin/Tumor-Associated Macrophage Axis in Development of Dermatofibrosarcoma Protuberans.
    Anticancer Res 2017 06;37(6):2867-2873
    Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
    Background/aim: Dermatofibrosarcoma protuberance (DFSP) is a fibrohistiocytic tumor of intermediate malignancy characterized by slow infiltrative growth and a high tendency to recur locally. Periostin is involved in modulating cell function and inducing the production of proinflammatory cytokines, chemokines, and matrix metalloproteinases (MMPs) from tumor-associated macrophages (TAMs) to promote fibrosis and tumor growth. This study aimed to examine the cancer stroma of DFSP, focusing on TAMs-related proteins and MMPs. Read More

    Pathologically Benign Lymph Nodes Can Mimic Malignancy on Imaging in Patients With Angiomatoid Fibrous Histiocytoma.
    Clin Orthop Relat Res 2017 Sep 23;475(9):2274-2279. Epub 2017 May 23.
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Background: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue neoplasm, and its rarity makes studying it difficult. We found that several of our patients with AFH presented with radiologically suspicious local lymph nodes that were sampled because of their imaging characteristics, but the nodes proved to be benign on pathologic evaluation. Although the frequency of this finding is unknown, it seems important for orthopaedic oncologists who care for patients with AFH to know whether suspicious-appearing associated nodes in these patients warrant aggressive management. Read More

    Plaque Like Giant Dermatofibroma: A Case Report.
    J Cutan Aesthet Surg 2017 Jan-Mar;10(1):51-53
    Department of Pathology, Amrita Institute of Medical sciences, Amrita univerisity, Kochi, Kerala, India.
    Dermatofibroma, also known as benign fibrous histiocytoma, is a soft-tissue tumour that usually occurs in the mid-adult life and shows a slight female predominance. Giant dermatofibroma, a very rare clinical variant, is characterised by its unusually large size, benign biological behaviour despite its large size and same histopathological characteristics as conventional dermatofibroma. We report a 63-year-old woman who presented with a large tumour on the scapular region which showed histopathological features of benign dermatofibroma. Read More

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