- Austin J Cocciolone,
- Jie Z Hawes,
- Marius Catalin Staiculescu,
- Elizabeth O Johnson,
- Monzur Murshed,
- Jessica E Wagenseil
Am J Physiol Heart Circ Physiol 2018 Apr 6. Epub 2018 Apr 6.
Washington University, United States.
Large, elastic arteries are composed of cells and a specialized extracellular matrix that provides reversible elasticity and strength. Elastin is the matrix protein responsible for this reversible elasticity that reduces the workload on the heart and dampens pulsatile flow in distal arteries. We summarize elastin protein biochemistry, self-association behavior, crosslinking process, and multi-step elastic fiber assembly that provide large arteries with their unique mechanical properties. Read More