268 results match your criteria Dermato-endocrinology[Journal]


Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance.

Dermatoendocrinol 2018 21;10(1):e1471958. Epub 2018 May 21.

Endocrinology Division, Department of Medicine, Hospital Universitario "Dr. José E. González", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico.

Any clinical/biochemical marker revealing obesity or diabetes before their appearance is valuable. Insulin resistance (IR) is present in both disorders many years before occurrence. Accordingly, we determined whether acanthosis nigricans (AN) in the knuckles is associated to higher insulin and homeostasis model assessment for estimated insulin resistance (HOMA-IR) index values, and assessed the influence of body-mass index (BMI) and the diagnostic performance of AN in the knuckles to detect IR. Read More

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May 2018
17 Reads

Relation between cutaneous and extracutaneous complications in pediatric patients with type 1 diabetes.

Dermatoendocrinol 2018 17;10(1):e1467717. Epub 2018 Aug 17.

Department of Dermatology, Faculty of Medicine, Misr University for Science & Technology (MUST), Cairo, Egypt.

: The relationship between cutaneous and extracutaneous complications in pediatric patients with type 1 diabetes is unclear. : The objective of the current study is to investigate the relationship between skin disorders and diabetic microangiopathic changes in pediatric and adolescent patients with type 1 diabetes. : Eighty patients with type 1 diabetes and 50 healthy controls were enrolled in the study. Read More

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August 2018
2 Reads

The rs2167270 polymorphism of leptin gene is associated with atopic dermatitis.

Dermatoendocrinol 2018 26;10(1):e1454191. Epub 2018 Mar 26.

Department of Clinical Pharmacology, Jordan University of Science and Technology, Irbid, Jordan.

Atopic dermatitis is a chronic inflammatory skin disease that arises because of complex environmental, immunological, and genetic interactions. Adipokines are bioactive mediators secreted from adipocytes of white adipose tissue and are known to have a role in body metabolism and regulation of immune responses. Leptin is a proinflammatory adipokine that functions mainly to regulate food intake and energy expenditure. Read More

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March 2018
2 Reads

Hormonal and dietary factors in acne vulgaris versus controls.

Dermatoendocrinol 2018 22;10(1):e1442160. Epub 2018 Feb 22.

Kogarah Railway Medical Centre, Kogarah, Sydney, Australia.

: Acne vulgaris is an inflammatory skin disorder with not as yet fully understood pathogenesis. In this controlled study, we assessed acne vulgaris patients for several possible pathogenic factors such as vitamin D deficiency, vegan diet, increased body mass index (BMI) and positive anti-transglutaminase antibody. : We screened 10 years of records at a family medicine clinic for patients diagnosed with acne vulgaris. Read More

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February 2018
8 Reads

Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis.

Dermatoendocrinol 2018 22;10(1):e1442159. Epub 2018 Feb 22.

International Centre for Skin Diseases DermAllegra, Am Markgrafenpark 6, Pommelsbrunn-Hohenstadt, Germany.

The pathogenetic role of vitamin D as well as its clinical correlation in inflammatory skin diseases is still uncertain. This study aimed to compare serum levels of 25(OH) vitamin D (calcidiol) in outpatients suffering from different skin diseases using the same laboratory method in one study. In routine serum samples of 1,532 patients from the previous 12 months we identified retrospectively 180 (mean age 49. Read More

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February 2018
8 Reads

The pivotal role of inflammation in scar/keloid formation after acne.

Dermatoendocrinol 2017 13;9(1):e1448327. Epub 2018 Mar 13.

Shanghai Dermatology Hospital, No.1278 Baode Road, Jing An District, Shanghai, China.

Most keloids are clinically observed as solid nodules or claw-like extensions. However, they appear hypoechoic on ultrasound images and are therefore easily confused with liquid features such as blood or vessels. The pathological manifestations of typical keloids also include prominent, thick blood vessels. Read More

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March 2018
8 Reads

Editorial - The 3rd International Conference on Sebaceous Gland, Acne, Rosacea and Related Disorders.

Dermatoendocrinol 2017 13;9(1):e1386419. Epub 2017 Oct 13.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P.R. China.

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October 2017
2 Reads

Multiple fractures in infants who have Ehlers-Danlos/hypermobility syndrome and or vitamin D deficiency: A case series of 72 infants whose parents were accused of child abuse and neglect.

Dermatoendocrinol 2017 16;9(1):e1279768. Epub 2017 Feb 16.

Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Campus, Boston, MA, USA.

: To increase the level of awareness that Ehlers-Danlos/hypermobility syndrome (EDS) and vitamin D deficiency are associated with infantile fragility fractures and radiologic features that may be mistakenly reported to be caused by non-accidental trauma due to Child Abuse and Neglect (CAN). : We constructed a case series, the largest to date, of infants with EDS who were vitamin D sufficient, insufficient and deficient and infants without EDS but with documented vitamin D deficiency and radiologic evidence of rickets who presented with multiple fractures originally diagnosed as being non-accidental and caused by child abuse. These infants were referred to the outpatient Bone Health Care Clinic at Boston University Medical Campus over a 6-year (2010-2015) period. Read More

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February 2017
15 Reads

ADT-G as a promising biomarker for peripheral hyperandrogenism in adult female acne.

Dermatoendocrinol 2017 13;9(1):e1361571. Epub 2017 Oct 13.

Escola Paulista de Medicina-Universidade Federal de São Paulo (EPM-Unifesp), Brazil.

Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and present some clinical differences compared to adolescent acne. Read More

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October 2017
3 Reads

Cleanser use could decrease numbers of Demodex Folliculorum in mild to moderate acne patients.

Dermatoendocrinol 2017 4;9(1):e1348444. Epub 2017 Oct 4.

Department of Dermatology, Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC INSERM 1431), Besançon University Hospital; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.

This study was to verify if the skin cleanser could help decrease the infection ratio of Demodex Folliculorum in acne patients. 132 participants with mild to moderate vulgaris acne participated in this monocentric, prospective, double-blind study. Dermatologists grading and Standardized Skin Surface Biopsy were performed in baseline and after using cleanser only 7 d later. Read More

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October 2017
3 Reads

Local cortisol activation is involved in EGF-induced immunosuppression.

Dermatoendocrinol 2017 26;9(1):e1412018. Epub 2017 Dec 26.

Department of Dermatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, Japan.

The major effects of the epidermal growth factor receptor (EGFR) signalling pathway on keratinocytes are cell proliferation, cell differentiation, and wound healing. In addition to these effects, an immunosuppressive effect of EGFR signalling has been reported. However, the precise mechanism of immunosuppression by EGFR signalling is not well understood. Read More

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December 2017
3 Reads

Thyroid autoimmunity in female post-adolescent acne: A case-control study.

Dermatoendocrinol 2017 12;9(1):e1405198. Epub 2017 Dec 12.

Kogarah Railway Medical Centre, Kogarah 2217, Sydney, Australia.

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December 2017
2 Reads

Cutaneous manifestations of diabetic peripheral neuropathy.

Dermatoendocrinol 2017 6;9(1):e1395537. Epub 2017 Dec 6.

Department of Dermatology, Venereology and Leprosy, Department of Endocrinology, Diabetes and Metabolism, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamilnadu, India.

There is a rise in number of people diagnosed with Diabetes Mellitus. The incidence is rising in modern Indian society because of Industrial development and drastically changing lifestyles. Diabetic neuropathies are microvascular disorders that are usually associated with the duration of Diabetes. Read More

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December 2017
3 Reads

Differential biological effects of dehydroepiandrosterone (DHEA) between mouse (B16F10) and human melanoma (BLM) cell lines.

Dermatoendocrinol 2017 20;9(1):e1389360. Epub 2017 Nov 20.

Department of Biochemistry, Kirksville College of Osteopathic Medicine, A.T. Still University, Kirksville, MO, USA.

Dehydroepiandrosterone (DHEA) is a weak androgen and had been shown to have anti-cancer, anti-adipogenic and anti-inflammatory effects on mouse and other rodent models, but not on humans, suggesting a systemic level difference between mouse and human. Our previous study on DHEA biological functions involving a variety of cell lines, suggested that the functional differences between mouse and human existed even at the cellular level. Hence, using mouse and human melanoma cell models, effects of DHEA on cell growth, mechanism of cell death and mechanism of DHEA action were studied. Read More

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November 2017
3 Reads

Untangling the most probable role for vitamin D in autism.

Dermatoendocrinol 2017 23;9(1):e1387702. Epub 2017 Oct 23.

Marquette University, Department of Mathematics, Statistics, and Computer Science, Milwaukee, WI, USA.

Recent studies indicate an important role for vitamin D in autism spectrum disorder (ASD), although its mechanism is not completely understood. The most puzzling aspect of ASD is that identical twins, who share identical DNA, do not have 100% concordance rates (∼88% for identical and ∼31% for fraternal twins). These findings provide major clues into the etiology: ASD must involve an environmental factor present in the prenatal milieu that both identical twins are not always exposed to because they do not always share it (i. Read More

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October 2017
3 Reads

Sebaceous-immunobiology is orchestrated by sebum lipids.

Dermatoendocrinol 2017 17;9(1):e1375636. Epub 2017 Oct 17.

Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

The major role of sebaceous glands in mammals is to produce sebum, which coats the epidermis and the hair providing waterproofing, thermoregulation and photoprotection. However, as the need for these functions decreased along the evolutionary changes in humans, a relevant question has been raised: are sebaceous glands and sebum the remnants of our mammalian heritage or do they have overtaken a far more complex role in human skin biology? Trying to provide answers to this question, this review introduces the evolving field of sebaceous immunobiology and puts into the focus the pathways that sebum lipids use to influence the immune milieu of the skin. By introducing possible modifiers of sebaceous lipogenesis and discussing the - human-specific - alterations in composition and amount of sebum, the attribute of sebum as a sensitive tool, which is capable of translating multiple signalling pathways into the dermal micro environment is presented. Read More

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October 2017
2 Reads

Sunbeds with UVB radiation can produce physiological levels of serum 25-Hydroxyvitamin D in healthy volunteers.

Dermatoendocrinol 2017 17;9(1):e1375635. Epub 2017 Oct 17.

Departments of Laboratory Medicine, and Pathobiology and Nutritional Sciences, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Circle, Toronto, ON, Canada.

Vitamin D is produced in the skin in response to UVB irradiation, from either sun exposure or UVB sunbeds. The objective of the current study was to characterize serum 25(OH)D response to regular sunbed use from several lamp outputs following their respective time exposure recommendations. There were three groups that tanned over 12 weeks during the winter months in dedicated sunbeds based on lamp outputs (100 W and 160 W low pressure fluorescent and 700 W high pressure filtered metal halide lamps) and a control group provided serum 25(OH)D samples at baseline and end-of-study. Read More

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October 2017
13 Reads

Recent advances in the endocrinology of the sebaceous gland.

Dermatoendocrinol 2017 23;9(1):e1361576. Epub 2018 Jan 23.

Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

The sebaceous gland, long considered an evolutionary relic with little-to-no physiological relevance in humans, has emerged in recent decades as a key orchestrator and contributor to many cutaneous functions. In addition to the classical physico-chemical barrier function of the skin against constant environmental challenges, a more novel, neuro-immune modulatory role has also emerged. As part of the complex intercellular communication network of the integumentary system, the sebaceous gland acts as a "relay station" in the skin for many endocrine factors. Read More

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January 2018
12 Reads

Clinical and histopathological characteristics in patients with scarring folliculitis type of acne inversa.

Dermatoendocrinol 2017 4;9(1):e1361575. Epub 2017 Oct 4.

Department of Dermatology, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China.

: This study was designed to study the clinical and histopathological characteristics of patients with the scarring folliculitis type acne inversa in Chinese population. : A total of 21 patients with acne inversa and 6 controls without known dermatological disease were recruited from outpatient department of dermatology and orthopedic surgery. Two-millimeter punch biopsies were taken from 8 patients with acne inversa and 6 controls, fixed in formalin, embedded in paraffin and stained with haematoxylin and eosin prior to histopathological analysis. Read More

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October 2017
8 Reads

Rosacea: Epidemiology, pathogenesis, and treatment.

Dermatoendocrinol 2017 4;9(1):e1361574. Epub 2017 Oct 4.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Rosacea is a chronic relapsing inflammatory skin disease with a high prevalence among adults of Northern European heritage with fair skin. Symptoms present in various combinations and severity, often fluctuating between periods of exacerbation and remission. Based on morphological characteristics, rosacea is generally classified into four major subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. Read More

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October 2017
3 Reads

Cutaneous fungal microbiome: yeasts in seborrheic dermatitis scalp in a randomized, comparative and therapeutic trial.

Dermatoendocrinol 2017 23;9(1):e1361573. Epub 2017 Oct 23.

Department of Dermatology, Federal University of Sao Paulo (UNIFESP), São Paulo, SP, Brazil.

spp in skin microbiome scalp has been implicated in seborrheic dermatitis pathogenesis. Thus, treatment based in antifungal combined to topical keratolitic agents have been indicated as well as oral isotretinoin as it reduces the sebum production, glandular's size and possesses anti-inflammatory properties. This randomized, comparative and therapeutic trial aimed toper form the genotypic identification of species before and after low-dose oral isotretinoin or topical antifungal treatments for moderate to severe seborrhea and/or seborrheic dermatitis on scalp. Read More

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October 2017
10 Reads

The effect on acne quality of life of topical azelaic acid 15% gel versus a combined oral contraceptive in adult female acne: A randomized trial.

Dermatoendocrinol 2017 13;9(1):e1361572. Epub 2017 Oct 13.

Escola Paulista de Medicina - Universidade Federal de São Paulo (EPM-Unifesp), Brazil.

Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and have show some clinical differences compared to adolescent acne. Read More

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October 2017
1 Read

Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne.

Dermatoendocrinol 2017 4;9(1):e1361570. Epub 2017 Oct 4.

Department of Dermatology, Department of Preventive Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.

Adult female acne is a chronic inflammatory, immune-mediated disease that affects the pilosebaceous unit in women in their 20s to 40s, and is considered different from acne vulgaris. is recognized by TLR-2, resulting in activation of this receptor and an inflammatory response through the B pathway. This therapeutic, interventional, open, randomized, evaluator-blinded and comparative trial included 38 adult women with moderate facial acne and 10 age-matched controls, all aged between 26 and 44 years. Read More

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October 2017
2 Reads

Seeking new acne treatment from natural products, devices and synthetic drug discovery.

Dermatoendocrinol 2017 4;9(1):e1356520. Epub 2017 Oct 4.

Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.

Despite lots of research on the pathogenesis of acne, the development of new therapeutic agents is still stagnant. Conventional agents which target multiple pathological processes have some serious side effects and this makes seeking new treatment options important for treating acne. As new therapeutic options, researchers are focusing on natural products, synthetic drugs and devices. Read More

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October 2017
2 Reads

Special types of folliculitis which should be differentiated from acne.

Dermatoendocrinol 2017 27;9(1):e1356519. Epub 2017 Sep 27.

Department of Dermatology, Beijing Hospital, National Center of Gerontology, Dongdan, Dongcheng District, Beijing, China.

Because both acne vulgaris and folliculitis can present as inflammatory erythematous papules, pustules or nodules, they are often hard to distinguish. The importance to distinguish between these 2 shall be stressed as their pathogenesis and therapies are different and misdiagnosis or missed diagnosis may lead to improper treatment. We will introduce several special types of folliculitis that should be differentiated from acne to increase our knowledge of the disorders with an acne-like manifestation. Read More

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September 2017
8 Reads

Insulin and Insulin-like growth factor-1 can activate the phosphoinositide-3-kinase /Akt/FoxO1 pathway in T cells .

Dermatoendocrinol 2017 4;9(1):e1356518. Epub 2017 Oct 4.

Department of Dermatology and Venereology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

Hyper-glycemic food increases insulin-like growth factor 1 (IGF-1) and insulin signaling and regulates endocrine responses and thereby may modulate the course of acne. Inflammation and adaptive immune responses have a pivotal role in all stages of acne. Recent hypothesis suggests that hyperglycemic food reduces nuclear forkhead box-O1 (FoxO1) transcription factor and may eventually induces acne. Read More

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October 2017
13 Reads

RIS-1/psoriasin expression in epithelial skin cells indicates their selective role in innate immunity and in inflammatory skin diseases including acne.

Dermatoendocrinol 2017 4;9(1):e1338993. Epub 2017 Oct 4.

Department of Dermatology and Allergology, RWTH Aachen University, Aachen, Germany.

Objective: RIS-1/psoriasin/S100A7 is an epithelial antimicrobial peptide, whose expression is upregulated in inflammatory skin diseases and is induced by retinoids. Its molecular expression was investigated in skin cell cultures and in skin specimens to better understand its role in inflammatory procedures of the pilosebaceous unit.

Methods: rtPCR and northern blotting of RIS-1/psoriasin and the retinoid-metabolizing genes CYP26AI and CRABP-II were performed in cells cultures (keratinocytes, sebocytes, fibroblasts, endothelial cells, melanocytes, lymphocytes and prostate cells; native and treated with retinoids) and in situ hybridization in normal and inflamed skin (acne, psoriasis). Read More

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October 2017
5 Reads

Effect of glycation focusing on the process of epidermal lipid synthesis in a reconstructed skin model and membrane fluidity of stratum corneum lipids.

Dermatoendocrinol 2017 4;9(1):e1338992. Epub 2017 Oct 4.

Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan.

We previously reported that epidermal glycation causes an increase in saturated fatty acid (FA) content in a differentiated reconstructed skin model and HaCaT cells. However, the relationship between ceramides (CERs) and glycation and their effects on stratum corneum (SC) barrier function was not elucidated. In this study, we investigated the effect of glycation on lipid content in 6-day-old cultured reconstructed skin. Read More

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October 2017
2 Reads

Topical 5-aminolevulinic photodynamic therapy with red light vs intense pulsed light for the treatment of acne vulgaris: A spilit face, randomized, prospective study.

Dermatoendocrinol 2017 13;9(1):e1375634. Epub 2017 Oct 13.

Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.

5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been an effective method for treating acne vulgaris. Red light is the most widely used light source while Intense pulsed lights (IPL) is reported effective and well-tolerated. The purpose of this study was to evaluate the efficacy and adverse reactions of ALA-PDT with red light on acne compared with ALA-PDT with IPL. Read More

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October 2017
4 Reads

Higher prevalence of clinical cardiovascular comorbidities in postmenopausal women with self-reported premenopausal hirsutism and/or oligo-amenorrhea.

Dermatoendocrinol 2017 22;9(1):e1356517. Epub 2017 Aug 22.

Department of Clinical Medicine, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.

Hirsutism is a common condition, being present in about 5-15% of women. It is characterized by the growth of terminal hair in a pattern typical for men, like as hair growth in upper lip, chin, cheek and lower and upper abdomen. Not infrequently, hirsutism is followed by other signs of hyerandrogenism such as alopecia, acne, and seborrhea. Read More

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August 2017
9 Reads

Cutaneous malignant melanoma incidences analyzed worldwide by sex, age, and skin type over personal Ultraviolet-B dose shows no role for sunburn but implies one for Vitamin D.

Dermatoendocrinol 2017 14;9(1):e1267077. Epub 2016 Dec 14.

Marquette University, Department of Mathematics, Statistics, and Computer Science, Milwaukee, WI, USA.

Because the incidence of cutaneous malignant melanoma (CMM) was reported to increase with increasing terrestrial UVR (290-400 nm) doses in the US back in 1975 and a recent publication showed no association exists with UVR exposure at all, we set out to fully elucidate the role of UVR in CMM. To achieve this goal, we analyzed the CMM incidences over latitude and estimated the average personal UVR dose in the US and numerous countries (> 50) on 5 continents around the world. Using data from the International Agency for Research on Cancer in 2005, we performed worldwide analysis of CMM over UVR dose by sex, age group (0-14, 15-29, 30-49, 50-69, 70-85+) and Fitzpatrick skin types I-VI. Read More

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December 2016
11 Reads

Early diagnosis in familial glucocorticoid deficiency.

Dermatoendocrinol 2017 6;9(1):e1310787. Epub 2017 Apr 6.

Pediatric Department, Sheikh Khalifa Medical City (SKMC), Abu Dhabi (AD), United Arab Emirates.

Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive condition, characterized by marked atrophy of zona fasiculata and reticalaris with preservation of zona glomerulosa. Out of more than 50 published cases, 18 patients died as a result of glucocorticoid insufficiency. The main objective of this report is to emphasize the early diagnosis and treatment in our 17 month-old patient. Read More

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April 2017
8 Reads

Evaluation of vitamin D3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting.

Dermatoendocrinol 2017 13;9(1):e1300213. Epub 2017 Apr 13.

Boston University Medical Center, Boston, MA, USA.

Supplementation by the general public with vitamin D at doses above the Tolerable Upper Level of Intake (UL) is becoming quite common. The objective of the current analysis was to characterize the effect of vitamin D supplementation at doses up to 15,000 IU/d in a community-based program on vitamin D status, calcium homeostasis as well as on kidney, liver and immune function. We evaluated data collected for 3,882 participants in a community program for whom there were blood measurements at program entry and at follow-up within 6-18 months between 2013 and 2015. Read More

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April 2017
7 Reads

Commercial tanning salons and melanoma risk.

Authors:
David G Hoel

Dermatoendocrinol 2017 14;9(1):e1270485. Epub 2016 Dec 14.

Department of Public Health Sciences, Medical University of South Carolina , Charleston, SC, USA.

There have been many case-control studies of melanoma and the use of indoor tanning equipment. A recent meta analysis of 8 credible studies in North America estimated an overall significant odds ratio of 1.23. Read More

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December 2016
5 Reads

Socio-epidemiologic aspects and cutaneous side effects of permanent tattoos in Germany - Tattoos are not restricted to a specific social phenotype.

Dermatoendocrinol 2017 15;9(1):e1267080. Epub 2016 Dec 15.

Saarland University Hospital, Department of Dermatology, Homburg/Saar , Germany.

: More and more people of all age classes have a tattoo. Intriguingly, there are multiple prejudices in the general population and published data that concern tattooed persons, such as being criminals, having a low education, being alcohol or drug abusers, or more risky in their life style. : To obtain and to evaluate sociodemographic data on tattooed persons, to investigate the incidence of tattoo-related cutaneous complications and to define personal risk factors and course of the persons after being tattooed concerning behavior of personal environment. Read More

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December 2016
13 Reads

BLT2 expression improves skin integrity and protects from alterations caused by hyperglycemia in type 2 diabetes.

Dermatoendocrinol 2017 14;9(1):e1267078. Epub 2016 Dec 14.

Departamento de Ciencias Médicas, Facultad de Medicina Odontología, Universidad de Antofagasta , Antofagasta, Chile.

Type 2 diabetes (T2D) can go undiagnosed for years, leading to a stage where chronic high blood sugar produces complications such as delayed wound healing. Reports have shown that BLT2 activation improves keratinocyte migration and wound healing, as well as protecting the epidermal barrier through the promotion of actin polymerization. The goal of this study was to elucidate the role of BLT2 expression in skin epithelial integrity in T2D. Read More

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December 2016
8 Reads

Environmental determinants of previtamin D synthesis in the United Arab Emirates.

Dermatoendocrinol 2017 6;9(1):e1267079. Epub 2017 Feb 6.

Imperial College London Diabetes Centre, Research Department, Abu Dhabi, United Arab Emirates.

Despite abundant sunshine throughout the year, vitamin D deficiency is endemic in the UAE. Solar radiation within the UVB range of the spectrum is required for the photosynthesis of previtamin D3 in the skin. Atmospheric transmission of UVB is strongly influenced by atmospheric conditions and solar zenith angle. Read More

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February 2017
2 Reads

The risks and benefits of sun exposure 2016.

Dermatoendocrinol 2016 Jan-Dec;8(1):e1248325. Epub 2016 Oct 19.

Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University Medical Center , Boston, MA, USA.

Public health authorities in the United States are recommending that men, women and children reduce their exposure to sunlight, based on concerns that this exposure will promote skin cancer. On the other hand, data show that increasing numbers of Americans suffer from vitamin D deficiencies and serious health problems caused by insufficient sun exposure. The body of science concerning the benefits of moderate sun exposure is growing rapidly, and is causing a different perception of sun/UV as it relates to human health. Read More

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October 2016
22 Reads

Estimated economic benefit of increasing 25-hydroxyvitamin D concentrations of Canadians to or above 100 nmol/L.

Dermatoendocrinol 2016 Jan-Dec;8(1):e1248324. Epub 2016 Oct 14.

Pure North S'Energy Foundation , Calgary, Alberta, Canada.

Mounting evidence from observational and clinical trials indicates that optimal vitamin D reduces the risk of many diseases. We used observational studies and recent data on 25-hydroxyvitamin D [25(OH)D] concentrations of Canadians from Cycle 3 of the Canadian Health Measures Survey to estimate the reduction in disease incidence, mortality rates, and the total economic burden (direct plus indirect) of disease if 25(OH)D concentrations of all Canadians were raised to or above 100 nmol/L. Recently, the mean 25(OH)D concentration of Canadians varied depending on age and season (51-69 nmol/L), with an overall mean of 61 nmol/L. Read More

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October 2016
14 Reads
4 Citations

The disintegrin-metalloproteinases ADAM10 and ADAM17 are upregulated in cutaneous squamous cell carcinomas.

Dermatoendocrinol 2016 Jan-Dec;8(1):e1228499. Epub 2016 Aug 31.

Department of Dermatology, The Saarland University Hospital , Homburg/Saar, Germany.

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August 2016
13 Reads

Worldwide cutaneous malignant melanoma incidences analyzed by sex, age, and skin type over time (1955-2007): Is HPV infection of androgenic hair follicular melanocytes a risk factor for developing melanoma exclusively in people of European-ancestry?

Dermatoendocrinol 2016 Jan-Dec;8(1):e1215391. Epub 2016 Jul 27.

Body of Knowledge, Inc., Division of Human Disease Research Worldwide , Racine, WI, USA.

The cutaneous malignant melanoma (CMM) incidence has been increasing in an exponential manner in certain populations around the world for over 7 decades. To help illuminate the etiology, we performed worldwide temporal (1955-2007) CMM incidence analysis by sex, age (0-14, 15-29, 30-49, 50-69, 70-85+), and skin type on 6 continents using data from the International Agency for Research on Cancer. We observe an exponential increase in the CMM incidence over time and an increase of about 2 orders of magnitude between age groups 0-14 and 15-29 exclusively in European-ancestry populations around the world independent of skin type (I-III or III-IV). Read More

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September 2016
10 Reads

Sneaky side effects and ineffectiveness of an immunotherapy with ipilimumab in a case of metastatic melanoma.

Dermatoendocrinol 2016 Jan-Dec;8(1):e1199307. Epub 2016 Jun 30.

Department of Dermatology, Saarland University Medical School , Homburg/Saar, Germany.

Ipilimumab is an anti-CTLA-4 antibody that is approved for the treatment of metastatic malignant melanoma. Side-effects are mostly immune-mediated and in many cases the lack of specific symptoms leads to delayed diagnosis and treatment of adverse events. We present the case of a female patient who experienced an uncommon combination of adverse reactions while undergoing therapy with ipilimumab and where the absence of specificity of the symptoms led to late diagnosis and treatment of side effects. Read More

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August 2016
9 Reads

Do studies reporting 'U'-shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects?

Dermatoendocrinol 2016 Jan-Dec;8(1):e1187349. Epub 2016 May 16.

Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University Medical Center , Boston, MA, USA.

Several reports describe U-shaped 25-hydroxyvitamin D [25(OH)D] concentration-health outcomes, including musculo-skeletal disorders such as falls and fractures, several cancers, cardiovascular disease (CVD), cognitive function, all-cause mortality rates, birth outcomes, allergic reactions, frailty, and some other disorders. This paper reviews reports of U-shaped outcome associations with vitamin D status for evidence of underlying pathophysiological processes, or of confounding, finding that some U-shaped associations appear to be biologically meaningful, but that many could well reflect confounding by factors such as lifestyle, or hypovitaminosis D-related disease onset being masked by self-supplementation that was begun too late to correct developing health problems but before baseline vitamin D status assessment. However, the various U-shaped associations for allergic reactions may be due to vitamin D modulation of the phenotype of the immune response, shifting the Th1-Th2 balance toward Th2 formation. Read More

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August 2016
19 Reads
17 Citations

Unmasking sarcoidosis following surgery for Cushing disease.

Dermatoendocrinol 2016 Jan-Dec;8(1):e983688. Epub 2016 Jun 7.

Department of Endocrinology, Aarhus University Hospital , Aarhus, Denmark.

We present a patient with Cushing disease apparently suppressing sarcoidosis, which was unmasked following surgical resection of a pituitary adrenocorticotropin (ACTH)-producing microadenoma. Case report and a short review of the literature published in this area. A 46-year-old Caucasian woman presented with symptoms of hypercortisolism such as progressive weight gain, Cushingoid appearance, proximal myopathy, easy bruising, and amenorrhea. Read More

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July 2016
12 Reads

Solar radiation and the incidence and mortality of leading invasive cancers in the United States.

Dermatoendocrinol 2016 Jan-Dec;8(1):e1162366. Epub 2016 Mar 28.

University of North Carolina-Asheville , Asheville, NC, USA.

Invasive cancer risk is inversely related to ultraviolet light exposure. This study explores relationships between cancer and the satellite-derived sunlight energy. We obtained the North America Land Data Assimilation System (NLDAS) daily average sunlight for the continental United States from 1999-2011. Read More

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May 2016
10 Reads

The role of geographical ecological studies in identifying diseases linked to UVB exposure and/or vitamin D.

Authors:
William B Grant

Dermatoendocrinol 2016 Jan-Dec;8(1):e1137400. Epub 2016 Jan 8.

Sunlight, Nutrition, and Health Research Center , San Francisco, CA, USA.

Using a variety of approaches, researchers have studied the health effects of solar ultraviolet (UV) radiation exposure and vitamin D. This review compares the contributions from geographical ecological studies with those of observational studies and clinical trials. Health outcomes discussed were based on the author's knowledge and include anaphylaxis/food allergy, atopic dermatitis and eczema, attention deficit hyperactivity disorder, autism, back pain, cancer, dental caries, diabetes mellitus type 1, hypertension, inflammatory bowel disease, lupus, mononucleosis, multiple sclerosis, Parkinson disease, pneumonia, rheumatoid arthritis, and sepsis. Read More

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May 2016
17 Reads
5 Citations

TNF-α increases the expression and activity of vitamin D receptor in keratinocytes: role of c-Jun N-terminal kinase.

Dermatoendocrinol 2016 Jan-Dec;8(1):e1137399. Epub 2016 Jan 8.

Basil and Gerald Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva, Israel; Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Several inflammatory mediators increase calcitriol production by epidermal keratinocytes. In turn calcitriol attenuates the keratinocyte inflammatory response. Since the effect of the in-situ generated calcitriol depends also on the sensitivity to the hormone we studied the effect of inflammatory cytokines on the response of HaCaT human keratinocytes to calcitriol by examining the expression and transcriptional activity of VDR. Read More

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May 2016
10 Reads

Local corticosterone activation by 11β-hydroxysteroid dehydrogenase 1 in keratinocytes: the role in narrow-band UVB-induced dermatitis.

Dermatoendocrinol 2016 Jan-Dec;8(1):e1119958. Epub 2016 Jan 5.

Department of Dermatology, Graduate School of Medicine, Osaka University , Suita, Osaka, Japan.

Keratinocytes are known to synthesize cortisol through activation of the enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). To confirm the function of 11β-HSD1 in keratinocytes during inflammation in vivo, we created keratinocyte-specific-11β-HSD1 knockout mice (K5-Hsd11b1-KO mice) and analyzed the response to narrow-band ultraviolet B (NB-UVB) irradiation. Firstly, we measured the mRNA and protein levels of 11β-HSD1 following NB-UVB irradiation and found that the expression of 11β-HSD1 in keratinocytes of mouse ear skin was enhanced at 3 and 24 hours after 250 mJ/cm(2), 500 mJ/cm(2), 1 J/cm(2), and 2 J/cm(2) NB-UVB irradiation. Read More

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May 2016
25 Reads

Stage I and II Stress Incontinence (SIC): High dosed vitamin D may improve effects of local estriol.

Dermatoendocrinol 2016 Jan-Dec;8(1):e1079359. Epub 2016 Apr 19.

Ordinarius, Dep. Urology, Int. University of Oradea , Oradea, Romania.

Unlabelled: After the age of 55 almost every third woman suffers from conditions of the incapability to retain urine when the intra-abdominal pressure is raised by different causes. So called stress incontinence. It' s caused by a predisposition in the family, weakness of the tissue, physical strain, deficiency in the metabolism, especially an increasing local estrogen deficiency and a local and systemic vitamin D deficiency. Read More

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May 2016
6 Reads

Advantage of soybean isoflavone as antiandrogen on acne vulgaris.

Dermatoendocrinol 2015 Jan-Dec;7(1):e1063751. Epub 2015 Jul 20.

Department of Nurition; Faculty of Medicine Diponegoro University; Hospital Kariadi ; Semarang, Indonesia.

Background: Acne vulgaris (AV) is the commonest skin disorder, whereas soybean isoflavone had been proved as antiandrogen that is it can inhibit the enzyme 3ß-hydroxysteroid dehydrogenase,17ß-hydroxysteroid dehydrogenase and 5α-reductase. The purpose of this study is to prove the advantage of soybean isoflavone as antiandrogen on AV.

Methods: this study is a clinical study using randomized pretest-posttest control group design. Read More

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September 2015
10 Reads