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Dermatol Ther 2021 Jul 30:e15078. Epub 2021 Jul 30.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Although tinea capitis is common in children, but it is rare in newborns. It should be differentiated with neonatal lupus erythematosus, nummular eczema, psoriasis, seborrheic dermatitis, erythema annular centrifugum, annular urticaria, and annular erythema of infancy. Tinea capitis usually needs oral antifungal therapy, but the data of use in newborn is limited. Read More

Med Clin North Am 2021 Jul;105(4):611-626

Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Department of Dermatology, Dartmouth-Hitchcock Medical Center, 18 Old Etna Road, Lebanon, NH 03766, USA.

This is a comprehensive and current guide for the diagnosis, differential diagnosis, treatment, and management of eczematous dermatitis, with a focus on atopic dermatitis, irritant and allergic contact dermatitis, hand dermatitis including recurrent vesicular and hyperkeratotic types, asteatotic dermatitis, and nummular or discoid dermatitis. Diagnostic options highlighted are clinical history, physical examination, and patch testing. Therapeutic options highlighted are moisturizers, topical corticosteroids, topical calcineurin inhibitors, crisaborole, phototherapy, and systemic medications including biologics. Read More

Isr Med Assoc J 2021 May;23(5):329-330

Laboratório DNA, Medical School, Federal University of Bahia, Salvador, Bahia, Brazil.

J Investig Allergol Clin Immunol 2021 Mar 3. Epub 2021 Mar 3.

Allergy Service. Hospital Universitario de Salamanca.

Recent advances in understanding T2 inflammation have broadened the diseases in which T2 inflammation can be involved. Dupilumab is a recently developed monoclonal antibody blocking the signaling of both IL-4 and IL13, two crucial cytokines of the T2 responses. New possible indications are increasingly exploring. Read More

Contact Dermatitis 2021 Jul 16;85(1):46-57. Epub 2021 Mar 16.

Department of Dermatology, Pennsylvania State University, State College, Pennsylvania, USA.

Background: Few studies have examined the relationship between nummular (discoid) eczema (NE) and allergic contact dermatitis (ACD).

Objective: To examine trends, associations, and clinical relevance of ACD in patients with NE who were referred for patch testing.

Methods: Retrospective analysis of 38 723 patients from the North American Contact Dermatitis Group. Read More

J Clin Med 2020 Aug 19;9(9). Epub 2020 Aug 19.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy.

Background: The clinical features of adult-onset atopic dermatitis (AD) are heterogeneous and the diagnosis can be a challenge. A new biologic drug (dupilumab) has been approved for moderate to severe AD in adult patients. The efficacy and safety have been demonstrated in clinical trials, but these studies do not reflect conditions in daily practice and do not consider the different clinical manifestations of AD. Read More

Recent Pat Inflamm Allergy Drug Discov 2020 ;14(2):146-155

Department of Paediatrics, The Chinese University of Hong Kong, Shatin and Department of Paediatrics and Adolescent Medicine, The Hong Kong Children's Hospital, Kowloon Bay, Kowloon, Hong Kong.

Background: Nummular eczema may mimic diseases that present with annular configuration and the differential diagnosis is broad.

Objective: This article aimed to provide an update on the evaluation, diagnosis, and treatment of nummular eczema.

Methods: A PubMed search was performed in using the key terms "nummular eczema", "discoid eczema", OR "nummular dermatitis". Read More

Acta Clin Croat 2019 Dec;58(4):595-603

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

When working with dermatology patients, the question sometimes arises which diagnostic tests and tools should be used for workup, particularly in cases of chronic urticaria (CU) and discoid nummular eczema, where the treatment of associated systemic diseases and infections may be crucial for patient outcome. The aim was to investigate retrospectively the influence of associated diseases on skin disease outcomes based on medical records of CU and nummular eczema patients in comparison to controls. We included patients admitted to our Dermatology Department over a 6-year period and analyzed their laboratory findings, related factors and outcomes recorded after two years of workup and treatment. Read More

Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):663-668

Department of Dermatology and STD, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, University of Delhi, Delhi, India.

Background: The high incidence, chronicity, frequent recurrences and severity of hand eczema leads to a massive impact on the quality of life. Despite great medical and socioeconomic importance, there is a paucity of data that addresses the cost of illness and economic factors associated with hand eczema. Most of the studies have originated from Europe and none have been reported from India. Read More

Int J Dermatol 2020 Jul 13;59(7):843-850. Epub 2020 May 13.

Department of Dermatology, Firat University Hospital, Elazig, Turkey.

Background: The use of dermoscopy for the evaluation of various inflammatory dermatoses has witnessed a gradual increase in recent years. The present study describes and highlights the importance of dermoscopic findings in the differential diagnosis of plaque psoriasis (PP), lichen planus (LP), mycosis fungoides (MF), pityriasis rosea (PR), and nummular dermatitis (ND) that mostly involve the trunk.

Methods: The study included 150 cases (PP:50, LP:30, MF:20, PR:30, ND:20). Read More

Int J Dermatol 2020 Jun 20;59(6):716-721. Epub 2020 Apr 20.

Dermatologic Clinic, Sapienza University of Rome, Rome, Italy.

Background: Atopic dermatitis (AD) is a chronic relapsing eczematous dermatitis typically affecting young patients in a percentage from 15 to 20%; although it typically affects young people and adults, recent papers highlighted the emerging of the disease in the elderly population.

Methods: The aim of the study was to identify the clinical criteria and allergic sensitization that may be able to support physicians and dermatologists in making a correct diagnosis of AD in the elderly. The second aim of this study was to investigate the incidence, the main features, the gender prevalence, the immunological profile, and comorbidities characterizing patients older than 65 years affected by AD. Read More

Dermatol Ther 2020 05 11;33(3):e13290. Epub 2020 Mar 11.

Department of Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy.

Nummular eczema (NE) is currently considered as one of the clinical phenotypes of atopic dermatitis (AD) of the adult. In this multicentre study, 30 adult patients (age ≥ 18 years) affected with nummular-like AD were treated with dupilumab, a monoclonal antibody against the receptor for interleukin(IL)-4 and IL-13. The evaluation of the results after 16 weeks of treatment showed a significant improvement of the disease, as demonstrated by reduction in Eczema Area Severity Score (EASI), visual analogue score (VAS) of pruritus, and Dermatology Life Quality Index (DLQI) scores. Read More

Rev Alerg Mex 2019 Oct-Dec;66(4):483-487

Instituto de Ciências da Saúde Izamar Milidiú da Silva, Servicio de Dermatologia, Río de Janeiro, Brasil.

Background: Adults with atopic dermatitis have had a persistent form in childhood or with an onset after the age of eighteen years. Late-onset atopic dermatitis may present with clinical heterogeneity and it often lacks the classic pattern of flexural dermatitis.

Clinical Case: A 26-year-old man with allergic rhinitis, with late-onset eczema, and an atypical nummular pattern on his trunk and limbs. Read More

Clin Exp Dermatol 2020 Jul 30;45(5):616-618. Epub 2020 Mar 30.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

Acta Dermatovenerol Croat 2019 Dec;27(4):273-274

Assoc. Prof. Halil Tekiner, MD, PhD, Department of the History of Pharmacy and Ethics, Erciyes University School of Pharmacy , 38280 Kayseri, Turkey;

The German dermatologist Paul Gerson Unna (1850-1929) is a prominent figure in the history of medicine for pioneering modern dermatopathology and dermotherapy (Figure 1) (1). Aside from writing extensively on anatomy, histopathology, and treatment of skin diseases, he contributed to medicine in many other ways: he originated the idea of using coated pills to enhance local absorption in the intestine, introduced ammonium bituminosulfonate (ichthyol) and resorcinol into medicine, and described several skin conditions including seborrheic dermatitis. Moreover, in 1881 he established a private clinic in Hamburg, Germany, which became a leading expert center in the diagnosis and treatment of skin disorders, hosting postgraduate physicians from all over the world for training (2). Read More

J Am Acad Dermatol 2020 05 8;82(5):1252-1255. Epub 2020 Jan 8.

Department of Dermatology, Stanford University School of Medicine, Redwood City, California. Electronic address:

J Dermatol 2019 Nov 8;46(11):e426-e427. Epub 2019 Jul 8.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

Dermatol Ther 2019 07 20;32(4):e12954. Epub 2019 May 20.

Department of Dermatology, University of California Davis School of Medicine, Sacramento, California.

A 40-year-old man with chronic history of refractory palmoplantar psoriasis presented with new onset of well-demarcated oval erythematous asteatotic plaques on bilateral shins after starting guselkumab therapy. Histopathology revealed chronic spongiotic dermatitis consistent with a diagnosis of nummular dermatitis. This case highlights a previously unreported adverse event to guselkumab therapy. Read More

Acta Oncol 2018 Nov 17;57(11):1586-1588. Epub 2018 Jul 17.

b Montefiore Medical Center, Department of Medicine, Division of Dermatology , Bronx , NY , USA.

Pediatr Dermatol 2018 Sep 26;35(5):611-615. Epub 2018 Jun 26.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Background/objectives: Nummular eczema in children is a chronic condition characterized by pruritic coin-shaped eczematous lesions that affect any part of the body and often become exudative. Mid- to high-potency topical corticosteroids are considered the mainstay treatment, but there are limited data on the use of systemic therapy for nummular eczema in children. The objective of the current study was to evaluate the efficacy and safety of methotrexate in children with severe nummular eczema. Read More

Am J Clin Hypn 2018 Jul;61(1):34-44

a University of South Florida , Tampa , FL, USA.

Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

Am Fam Physician 2018 Jan;97(1):38-44

Emory University School of Medicine, Atlanta, GA, USA.

Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. Read More

Clin Med Res 2017 12 11;15(3-4):75-87. Epub 2017 Dec 11.

Politeknik Kesehatan Jakarta, Indonesia.

Moisturizer is a major component of basic daily skin care, particularly in presence of epidermal barrier alteration and reduced epidermal water content. It is an important part of a dermatologist's strategy to maintain skin health as well as treating various dermatoses which co-exist with skin dryness and are linked to impaired skin barrier function, such as in atopic disorders as well as other types of dermatitis. Mastering the knowledge regarding mechanism of action, application, dosage, adverse effects as well as specific clinical usage of moisturizers is a must for a dermatologist in order to support their use, particularly for evidence-based, therapeutic purposes. Read More

Clin Dermatol 2017 Jul - Aug;35(4):354-359. Epub 2017 Mar 24.

Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:

Atopic dermatitis is a complex, systemic inflammatory disorder associated with a variety of clinical features. The original criteria of Hanifin and Rajka include major criteria and a list of about two dozen minor criteria however, even the minor criteria do not include some features of atopic dermatitis noted less commonly but still seen with some frequency. This contribution first reviews the common clinical appearance of atopic dermatitis in infancy, childhood, and adulthood, as well as the less typical appearances, including lichenoid atopic dermatitis; juvenile plantar dermatosis; nummular-type atopic dermatitis; follicular atopic dermatitis; alopecia of atopic dermatitis; eczema coxsackium; and psoriasiform, perineal, and lip licker's dermatitis. Read More

Skinmed 2017;15(3):221-222. Epub 2017 Jun 1.

Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI;

An otherwise healthy 36-year-old Caucasian woman, without prior history of atopic dermatitis or eczema, presented to an outside dermatologist with a generalized, severely pruritic eruption involving the entire body except the face. One month previously, she had used a 50% trichloroacetic acid tattoo removal solution on a blue-colored tattoo on the medial aspect of the left ankle. The patient's eruption persisted for 7 months, and after several attempts to slowly taper her prednisone dose, she presented to our institution. Read More

Dermatol Clin 2017 Jul;35(3):299-302

Department of Dermatology, Oregon Health & Science University, 3303 Bond Avenue, Portland, OR 97239, USA. Electronic address:

Atopic dermatitis therapy can be a challenge in many cases. Persistence into adulthood often reflects the more severe cases and such patients have the added problems of hand eczema and thick nummular lesions that resist topical medications. Within this group are patients labeled as having adult-onset atopic dermatitis, a designation that is hard to define and probably represents those whose childhood eczema was simply forgotten. Read More

J Am Acad Dermatol 2017 Jul 9;77(1):130-135. Epub 2017 Feb 9.

Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.

Background: The histopathologic differences among palmar psoriasis (PP), hand eczema (HE), and hyperkeratotic hand dermatitis (HHD) have been poorly described.

Objectives: We sought to distinguish among PP, HE, and HHD on a histopathologic basis.

Methods: We retrospectively analyzed the histology of hematoxylin-eosin-stained sections obtained from 96 patients diagnosed with PP, HE, or HHD. Read More

J Dermatol 2017 May 3;44(5):533-537. Epub 2016 Dec 3.

Department of Dermatology, Kosin University College of Medicine, Busan, Korea.

Lichen aureus (LA) is a variant of pigmented purpuric dermatosis that is characterized clinically by rust macules, papules or plaques, mainly on the legs. In some cases, LA can be difficult to be distinguished from nummular eczema (NE) with the naked eye. Dermoscopy can be applied to skin lesions, revealing additional features that can be highly valuable for correct diagnosis. Read More

Arch Argent Pediatr 2016 Aug 1;114(4):e241-4. Epub 2016 Aug 1.

Centro de Salud "Severo Ochoa", Gijón, Asturias, España.

Nummular eczema or dermatitis is an uncommon paediatric pathology. It is presented as red-purplish small papules and vesicles that join to form exudative circular patches and then to eczematous or lichenified patches with discoid shape. The lesions appear predominantly on the extensor surface of extremities, although they can appear in trunk, hands or feet. Read More