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J Clin Med 2022 Jun 27;11(13). Epub 2022 Jun 27.

Department of Dermatology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.

Background And Aims: Multiple sclerosis is a disease of the central nervous system, whose treatment often involves the use of monoclonal antibodies. This can lead to a series of complications that the clinician should pay attention to and accordingly adjust the therapy. We aim to emphasize real-life experiences with adverse cutaneous reactions to monoclonal antibodies by presenting a series of two cases from our clinic. Read More

Curr Opin Allergy Clin Immunol 2022 08 28;22(4):242-249. Epub 2022 Jun 28.

Department of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy.

Purpose Of Review: To report current knowledge on the different clinical phenotypes of adult atopic dermatitis. Possible therapeutic intervention in relation to phenotype is also evaluated.

Recent Findings: Atopic dermatitis is a chronic inflammatory disease affecting up to 10% of adults. Read More

J Eur Acad Dermatol Venereol 2022 May 27. Epub 2022 May 27.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Contact Dermatitis 2022 Jul 17;87(1):20-27. Epub 2022 Mar 17.

Department of Dermatology, University Hospital Antwerp (UZA) and Research group Immunology, INFLA-MED Centre of Excellence, University of Antwerp, Antwerp, Belgium.

This review aims to provide a clinically useful update regarding the role of formaldehyde (FA) and its five main releasers (FRs) quaternium-15, diazolidinyl urea, DMDM hydantoin, imidazolidinyl urea, and 2-bromo-2-nitropropane-1,3-diol (bronopol) in contact allergy and allergic contact dermatitis. These ubiquitous preservatives are still often present, and sometimes undeclared, in cosmetics, pharmaceuticals, medical devices, household detergents, and chemical (industrial) products. In Europe, the use of free FA and quaternium-15 in cosmetics is forbidden and contact allergy rates have been found to be stable to decreasing. Read More

Clin Dermatol 2022 Jan 1. Epub 2022 Jan 1.

Department of Dermatology and Venereology, Istanbul Arel University, School of Medicine; Department of Dermatology, Memorial Health Group, Atasehir and Sisli Hospital. Electronic address:

Papulosquamous diseases represent a commonly encountered group of cutaneous disorders in dermatology. Lesions can present with papules and plaques in various configurations, including annular forms. Some of these disorders are expected to appear in annular configurations, such as pityriasis rosea and subcorneal pustular dermatosis. Read More

Acta Derm Venereol 2022 Mar 8;102:adv00664. Epub 2022 Mar 8.

Department of Dermatology, Venereology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, DE-24105 Kiel, Germany.

Nummular (coin-shaped) and classical (flexural) atopic dermatitis differ morphologically, but no other distinguishing features are known. The aim of this study was to determine differences and similarities of both variants in children. Detailed interviews, clinical examinations, biophysical measurements and electron microscopic analyses were performed on 10 children with nummular atopic dermatitis, 14 with classical atopic dermatitis and 10 healthy controls. Read More

Clin Dermatol 2021 Sep-Oct;39(5):772-783. Epub 2021 May 21.

Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut, USA. Electronic address:

Early identification of cutaneous manifestations of alcohol and illicit drug use can aid in the diagnosis and management of these uses, as well as their sequelae. In addition, the effects of alcohol and illicit drug use on the skin can result in significant morbidity. Alcohol misuse can present with jaundice, pruritus, pigmentary alterations, urticaria, hair and nail changes, and oral changes. Read More

Contact Dermatitis 2022 Feb 18;86(2):122-123. Epub 2021 Oct 18.

Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, Bari, Italy.

J Fam Pract 2021 Jun;70(5):252

University of Texas Health at San Antonio.

The Comparison: A) Pink scaling plaques and erythematous erosions in the antecubital fossae of a 6-year-old White boy. B) Violaceous, hyperpigmented, nummular plaques on the back and extensor surface of the right arm of a 16-month-old Black girl. C) Atopic dermatitis and follicular prominence/accentuation on the neck of a young Black girl. Read More

Dermatol Ther 2021 09 15;34(5):e15078. Epub 2021 Aug 15.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Although tinea capitis is common in children, but it is rare in newborns. It should be differentiated with neonatal lupus erythematosus, nummular eczema, psoriasis, seborrheic dermatitis, erythema annular centrifugum, annular urticaria, and annular erythema of infancy. Tinea capitis usually needs oral antifungal therapy, but the data of use in newborn is limited. Read More

Med Clin North Am 2021 Jul;105(4):611-626

Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Department of Dermatology, Dartmouth-Hitchcock Medical Center, 18 Old Etna Road, Lebanon, NH 03766, USA.

This is a comprehensive and current guide for the diagnosis, differential diagnosis, treatment, and management of eczematous dermatitis, with a focus on atopic dermatitis, irritant and allergic contact dermatitis, hand dermatitis including recurrent vesicular and hyperkeratotic types, asteatotic dermatitis, and nummular or discoid dermatitis. Diagnostic options highlighted are clinical history, physical examination, and patch testing. Therapeutic options highlighted are moisturizers, topical corticosteroids, topical calcineurin inhibitors, crisaborole, phototherapy, and systemic medications including biologics. Read More

Isr Med Assoc J 2021 May;23(5):329-330

Laboratório DNA, Medical School, Federal University of Bahia, Salvador, Bahia, Brazil.

J Investig Allergol Clin Immunol 2022 Apr 3;32(2):97-115. Epub 2021 Mar 3.

Allergy Service, Hospital Universitario de Salamanca, Spain.

Recent advances in our understanding of T2 inflammation have revealed more diseases in which T2 inflammation is involved. Dupilumab is a recently developed monoclonal antibody that blocks signaling of IL-4 and IL-13, both of which are crucial cytokines in the T2 response. New possible indications are increasingly explored and include skin diseases, such as prurigo nodularis, nummular eczema, allergic contact dermatitis, chronic hand eczema, spontaneous chronic urticaria, bullous pemphigoid, alopecia areata, and Netherton syndrome, as well as respiratory diseases, such as allergic bronchopulmonary aspergillosis, chronic eosinophilic pneumonia, and allergic rhinitis. Read More

Contact Dermatitis 2021 Jul 16;85(1):46-57. Epub 2021 Mar 16.

Department of Dermatology, Pennsylvania State University, State College, Pennsylvania, USA.

Background: Few studies have examined the relationship between nummular (discoid) eczema (NE) and allergic contact dermatitis (ACD).

Objective: To examine trends, associations, and clinical relevance of ACD in patients with NE who were referred for patch testing.

Methods: Retrospective analysis of 38 723 patients from the North American Contact Dermatitis Group. Read More

J Clin Med 2020 Aug 19;9(9). Epub 2020 Aug 19.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy.

Background: The clinical features of adult-onset atopic dermatitis (AD) are heterogeneous and the diagnosis can be a challenge. A new biologic drug (dupilumab) has been approved for moderate to severe AD in adult patients. The efficacy and safety have been demonstrated in clinical trials, but these studies do not reflect conditions in daily practice and do not consider the different clinical manifestations of AD. Read More

Recent Pat Inflamm Allergy Drug Discov 2020 ;14(2):146-155

Department of Paediatrics, The Chinese University of Hong Kong, Shatin and Department of Paediatrics and Adolescent Medicine, The Hong Kong Children's Hospital, Kowloon Bay, Kowloon, Hong Kong.

Background: Nummular eczema may mimic diseases that present with annular configuration and the differential diagnosis is broad.

Objective: This article aimed to provide an update on the evaluation, diagnosis, and treatment of nummular eczema.

Methods: A PubMed search was performed in using the key terms "nummular eczema", "discoid eczema", OR "nummular dermatitis". Read More

Acta Clin Croat 2019 Dec;58(4):595-603

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

When working with dermatology patients, the question sometimes arises which diagnostic tests and tools should be used for workup, particularly in cases of chronic urticaria (CU) and discoid nummular eczema, where the treatment of associated systemic diseases and infections may be crucial for patient outcome. The aim was to investigate retrospectively the influence of associated diseases on skin disease outcomes based on medical records of CU and nummular eczema patients in comparison to controls. We included patients admitted to our Dermatology Department over a 6-year period and analyzed their laboratory findings, related factors and outcomes recorded after two years of workup and treatment. Read More

Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):663-668

Department of Dermatology and STD, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, University of Delhi, Delhi, India.

Background: The high incidence, chronicity, frequent recurrences and severity of hand eczema leads to a massive impact on the quality of life. Despite great medical and socioeconomic importance, there is a paucity of data that addresses the cost of illness and economic factors associated with hand eczema. Most of the studies have originated from Europe and none have been reported from India. Read More

Int J Dermatol 2020 Jul 13;59(7):843-850. Epub 2020 May 13.

Department of Dermatology, Firat University Hospital, Elazig, Turkey.

Background: The use of dermoscopy for the evaluation of various inflammatory dermatoses has witnessed a gradual increase in recent years. The present study describes and highlights the importance of dermoscopic findings in the differential diagnosis of plaque psoriasis (PP), lichen planus (LP), mycosis fungoides (MF), pityriasis rosea (PR), and nummular dermatitis (ND) that mostly involve the trunk.

Methods: The study included 150 cases (PP:50, LP:30, MF:20, PR:30, ND:20). Read More

Int J Dermatol 2020 Jun 20;59(6):716-721. Epub 2020 Apr 20.

Dermatologic Clinic, Sapienza University of Rome, Rome, Italy.

Background: Atopic dermatitis (AD) is a chronic relapsing eczematous dermatitis typically affecting young patients in a percentage from 15 to 20%; although it typically affects young people and adults, recent papers highlighted the emerging of the disease in the elderly population.

Methods: The aim of the study was to identify the clinical criteria and allergic sensitization that may be able to support physicians and dermatologists in making a correct diagnosis of AD in the elderly. The second aim of this study was to investigate the incidence, the main features, the gender prevalence, the immunological profile, and comorbidities characterizing patients older than 65 years affected by AD. Read More

Dermatol Ther 2020 05 11;33(3):e13290. Epub 2020 Mar 11.

Department of Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy.

Nummular eczema (NE) is currently considered as one of the clinical phenotypes of atopic dermatitis (AD) of the adult. In this multicentre study, 30 adult patients (age ≥ 18 years) affected with nummular-like AD were treated with dupilumab, a monoclonal antibody against the receptor for interleukin(IL)-4 and IL-13. The evaluation of the results after 16 weeks of treatment showed a significant improvement of the disease, as demonstrated by reduction in Eczema Area Severity Score (EASI), visual analogue score (VAS) of pruritus, and Dermatology Life Quality Index (DLQI) scores. Read More

Rev Alerg Mex 2019 Oct-Dec;66(4):483-487

Instituto de Ciências da Saúde Izamar Milidiú da Silva, Servicio de Dermatologia, Río de Janeiro, Brasil.

Background: Adults with atopic dermatitis have had a persistent form in childhood or with an onset after the age of eighteen years. Late-onset atopic dermatitis may present with clinical heterogeneity and it often lacks the classic pattern of flexural dermatitis.

Clinical Case: A 26-year-old man with allergic rhinitis, with late-onset eczema, and an atypical nummular pattern on his trunk and limbs. Read More

Clin Exp Dermatol 2020 Jul 30;45(5):616-618. Epub 2020 Mar 30.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

Acta Dermatovenerol Croat 2019 Dec;27(4):273-274

Assoc. Prof. Halil Tekiner, MD, PhD, Department of the History of Pharmacy and Ethics, Erciyes University School of Pharmacy , 38280 Kayseri, Turkey;

The German dermatologist Paul Gerson Unna (1850-1929) is a prominent figure in the history of medicine for pioneering modern dermatopathology and dermotherapy (Figure 1) (1). Aside from writing extensively on anatomy, histopathology, and treatment of skin diseases, he contributed to medicine in many other ways: he originated the idea of using coated pills to enhance local absorption in the intestine, introduced ammonium bituminosulfonate (ichthyol) and resorcinol into medicine, and described several skin conditions including seborrheic dermatitis. Moreover, in 1881 he established a private clinic in Hamburg, Germany, which became a leading expert center in the diagnosis and treatment of skin disorders, hosting postgraduate physicians from all over the world for training (2). Read More

J Am Acad Dermatol 2020 05 8;82(5):1252-1255. Epub 2020 Jan 8.

Department of Dermatology, Stanford University School of Medicine, Redwood City, California. Electronic address:

J Dermatol 2019 Nov 8;46(11):e426-e427. Epub 2019 Jul 8.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

Dermatol Ther 2019 07 20;32(4):e12954. Epub 2019 May 20.

Department of Dermatology, University of California Davis School of Medicine, Sacramento, California.

A 40-year-old man with chronic history of refractory palmoplantar psoriasis presented with new onset of well-demarcated oval erythematous asteatotic plaques on bilateral shins after starting guselkumab therapy. Histopathology revealed chronic spongiotic dermatitis consistent with a diagnosis of nummular dermatitis. This case highlights a previously unreported adverse event to guselkumab therapy. Read More

Acta Oncol 2018 Nov 17;57(11):1586-1588. Epub 2018 Jul 17.

b Montefiore Medical Center, Department of Medicine, Division of Dermatology , Bronx , NY , USA.

Pediatr Dermatol 2018 Sep 26;35(5):611-615. Epub 2018 Jun 26.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Background/objectives: Nummular eczema in children is a chronic condition characterized by pruritic coin-shaped eczematous lesions that affect any part of the body and often become exudative. Mid- to high-potency topical corticosteroids are considered the mainstay treatment, but there are limited data on the use of systemic therapy for nummular eczema in children. The objective of the current study was to evaluate the efficacy and safety of methotrexate in children with severe nummular eczema. Read More