116,799 results match your criteria Dermatitis Nummular


Phytophotodermatitis related to Peucedanum paniculatum Loisel, a case report.

Contact Dermatitis 2018 Nov 22. Epub 2018 Nov 22.

Centre Anti Poison, Hôpital Fernand-Widal, Paris, France.

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November 2018

The Journal of Allergy and Clinical Immunology: In Practice 2018 Highlights.

J Allergy Clin Immunol Pract 2018 Dec 14. Epub 2018 Dec 14.

Department of Allergy, Kaiser Permanente Southern California, San Diego, CA; Department Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.

A large number of clinically impactful studies and reviews were published in this Journal in 2018. This article provides highlights of the original research published in 2018 issues of JACI: In Practice on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, eosinophilic disorders, food allergy, immune deficiency, rhinitis/upper respiratory disease, and urticaria/angioedema. Within each topic, practical aspects of diagnosis and management are emphasized. Read More

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December 2018

Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning.

J Clin Pharmacol 2018 Dec 17. Epub 2018 Dec 17.

Pfizer Inc., Groton, CT, USA.

Atopic dermatitis is a chronic eczematous, pruritic, inflammatory skin condition affecting children and adults. Tofacitinib is a Janus kinase inhibitor. The efficacy, safety, and pharmacokinetics of 2% tofacitinib ointment twice daily have been evaluated in a 4-week phase 2a multisite randomized, double-blind, vehicle-controlled, parallel-group study (NCT02001181) in adult patients with mild to moderate atopic dermatitis and 2% to 20% body surface area (BSA) involvement. Read More

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December 2018
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Could we use the erythema grading of the CADESI4 as a simple instrument for future short-duration clinical trials of dogs with atopic dermatitis?

Authors:
Thierry Olivry

Vet Dermatol 2018 Dec 17. Epub 2018 Dec 17.

Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.

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December 2018

The impact of pediatric atopic dermatitis on families: A review.

Pediatr Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Department of Dermatology, University of California San Francisco, San Francisco, California.

Background: Atopic dermatitis (AD) is an extremely common childhood disease, with considerable impact on the quality of life of affected children and their families. While pruritus is the hallmark symptom of this disease, AD has been well-documented to impact patients beyond physical symptoms, resulting in behavior problems, mood disorders, and sleep disturbance.

Objective: This literature review outlines how atopic dermatitis impacts the quality of life of families of children affected by AD. Read More

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December 2018

Psoriasis and Atopic Dermatitis "Resistant" to Topical Treatment Responds Rapidly to Topical Desoximetasone Spray.

J Cutan Med Surg 2018 Dec 17:1203475418818082. Epub 2018 Dec 17.

1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose:: Topical corticosteroids (TS) are a treatment for atopic dermatitis (AD) and psoriasis (Ps). We assessed whether use of a TS under conditions designed to enhance adherence would be effective in patients who "failed" TS in the outpatient setting.

Methods:: Individuals with treatment-resistant Ps or AD were recruited (AD, n = 12; Ps, n = 12). Read More

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December 2018

"Slime" dermatitis, a fad-associated chronic hand dermatitis.

Pediatr Dermatol 2018 Dec 16. Epub 2018 Dec 16.

Division of Dermatology, Children's National Health Center, Washington, District of Columbia.

"Slime" is the colloquial name for a non-Newtonian viscoelastic putty-like substance that is currently a popular plaything among pre-teens and adolescents. Several ingredients in homemade slime recipes may cause irritant or allergic contact dermatitis. We report two children who developed slime-associated chronic hand dermatitis, more prominently on their dominant hand. Read More

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December 2018

Pancreatic Enzyme Supplementation in Patients with Atopic Dermatitis and Food Allergies: An Open-Label Pilot Study.

Paediatr Drugs 2018 Dec 17. Epub 2018 Dec 17.

Division of Gastroenterology, Departments of Medicine and Pediatrics, Research Institute of the McGIll University Health Centre, 1650 Cedar Avenue C10.145, Montreal, QC, H3G 1A4, Canada.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects both patients and their families. Current therapies often alleviate symptoms but do not prevent or eradicate the disease.

Objectives: Our objective was to determine whether pancreatic enzyme supplementation is an effective and safe treatment in refractory pediatric AD associated with food allergies. Read More

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December 2018
1 Read

Lifitegrast add-on treatment for dupilumab-induced ocular surface disease (DIOSD): A novel case report.

JAAD Case Rep 2019 Jan 4;5(1):34-36. Epub 2018 Dec 4.

Comprehensive Eye Care of Central Ohio, Westerville, Ohio.

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January 2019

A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis.

J Am Acad Dermatol 2019 Jan 3;80(1):89-98.e3. Epub 2018 Jul 3.

ICON plc, Research Triangle Park, North Carolina.

Background: Safe and efficacious topical treatments are needed for atopic dermatitis (AD).

Objective: We assessed the safety and efficacy of tapinarof cream (2 concentrations and 2 application frequencies) in patients with AD.

Methods: A double-blind, vehicle-controlled, randomized, 6-arm trial (1:1:1:1:1:1) in patients age 12 to 65 years, with body surface area involvement of at least 5% to 35% and an Investigator's Global Assessment score of 3 or higher (moderate to severe) at baseline. Read More

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January 2019

Orf virus infection of human keratinocytes and dermal fibroblasts: limited virus detection and interference with intercellular adhesion molecule-1 up-regulation.

Exp Dermatol 2018 Dec 15. Epub 2018 Dec 15.

Institute of Immunology/Molecular Pathogenesis, Center for Biotechnology and Biomedicine, College of Veterinary Medicine, Leipzig University, Leipzig, Germany.

Orf virus (Parapoxvirus ovis, ORFV) is a dermatotropic virus causing pustular dermatitis in small ruminants and humans. We analyzed isolated human primary keratinocytes (KC) and dermal fibroblasts (FB) for cell death and virus replication by infection with a patient-derived ORFV isolate. ORFV infection was associated with rapid induction of cell death in KC allowing for considerable virus removal. Read More

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December 2018
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Dramatic response of nivolumab-associated psoriasiform dermatitis to etoposide.

Eur J Cancer 2018 Dec 13;107:97-99. Epub 2018 Dec 13.

The University of Texas Health Science Center at Houston McGovern Medical School, Dermatology Department, 6655 Travis Street, Suite 700, Houston, TX 77030, USA; MD Anderson Cancer Center, Department of Pathology, 1515 Holcombe Bvd, Houston, Texas, 77030, USA. Electronic address:

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December 2018
1 Read

Skin tape stripping: which layers of the epidermis are removed?

Contact Dermatitis 2018 Dec 15. Epub 2018 Dec 15.

The National Allergy Research Centre, Department of Dermatology and Allergy, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark.

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December 2018
1 Read

Anaphylactic reaction caused by skin contact with disinfectant chloramine-T.

Contact Dermatitis 2018 Dec 15. Epub 2018 Dec 15.

Department of Dermatology, University of Groningen, University Medical Center Groningen, The Netherlands.

Chloramine-T (CAS no. 7080-50-4, syn. sodium p-toluenesulfonchloramide) is a crystalline powder on a chlorine basis, commonly used as a sterilizer, antiseptic, disinfectant and chemical reagent. Read More

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December 2018
1 Read

Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice.

Biomed Pharmacother 2019 Jan 26;109:1876-1883. Epub 2018 Nov 26.

Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha 410011, China.

Psoriasis is a chronic, immune-mediated inflammatory skin disease. As psoriasis rarely occurs in nonhuman animals, the lack of an ideal animal model reflecting the histopathological and molecular immunological characteristics of psoriasis remains an urgent issue. In the present study, an imiquimod-induced psoriasis-like dermatitis mouse model was constructed under natural immune conditions and verified by evaluations of the Psoriasis Area and Severity Index (PASI) score and Baker score, H&E staining, immunohistochemical examination of the CD3 and Gr1 levels, measurement of plasmacytoid dendritic cell- (pDC) and Th17-associated cytokine levels, and evaluation of p65 phosphorylation and TLR7 expression. Read More

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January 2019
1 Read

A CCR4 antagonist ameliorates atopic dermatitis-like skin lesions induced by dibutyl phthalate and a hydrogel patch containing ovalbumin.

Biomed Pharmacother 2019 Jan 13;109:1437-1444. Epub 2018 Nov 13.

Division of Chemotherapy, Kindai University, Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka 577-8502, Japan. Electronic address:

CCR4 is a chemokine receptor highly expressed by Th2 cells, and regarded as a potential therapeutic target for atopic dermatitis (AD). CCL17 and CCL22 are the CCR4 ligands, and thymic stromal lymphopoietin (TSLP) is shown to promote the expression of CCL17 and CCL22 by dendritic cells. Here, by using dibutyl phthalate (DBP), a TSLP inducer, and a hydrogel patch as a transcutaneous delivery device for ovalbumin, we developed a novel murine AD model and investigated the effect of Compound 22, a CCR4 antagonist. Read More

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January 2019
1 Read

Tezepelumab, an anti-TSLP monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

MedImmune, Cambridge, UK.

Background: Tezepelumab (AMG 157/MEDI9929), a first-in-class monoclonal antibody, targets thymic stromal lymphopoietin, a cytokine implicated in atopic dermatitis (AD) pathogenesis.

Objective: Evaluate efficacy and safety of tezepelumab in adults with moderate to severe AD.

Methods: In this phase 2a study (NCT02525094), 113 patients were randomized 1:1 to subcutaneous tezepelumab 280 mg or placebo every 2 weeks, plus Class 3 topical corticosteroids (TCS). Read More

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December 2018
4 Reads

The role of the skin microbiome in atopic dermatitis.

Ann Allergy Asthma Immunol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, University of California, San Diego, CA,. Electronic address:

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December 2018
1 Read

PROTECT - Trial: A cluster RCT to study the effectiveness of a repositioning aid and tailored repositioning to increase repositioning compliance.

J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.

Skin Integrity Research Group (SKINT), University Centre for Nursing and Midwifery, Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.

Aim: To study the effectiveness of tailored repositioning and a turning and repositioning system on: (1) nurses' compliance to repositioning frequencies; (2) body posture of patients after repositioning; (3) incidence of pressure ulcers and incontinence-associated dermatitis; (4) nurses' and patients' preferences, comfort and acceptability; and (5) budget impact.

Background: Patient-tailored systematic repositioning is key in pressure ulcer prevention. To date, a clinical decision-making tool is lacking and compliance to pressure ulcer prevention guidelines is low. Read More

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December 2018
1 Read

The effect of anti-IL-17 treatment on the reaction to a nickel patch test in patients with allergic contact dermatitis.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

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December 2018

What's new in the treatment of atopic dermatitis?

Dermatol Ther 2018 Nov 22:e12787. Epub 2018 Nov 22.

Department of Health Sciences, Unit of Dermatology, "Magna Graecia" University, Catanzaro, Italy.

Atopic dermatitis (AD) is a pruritic, chronic and inflammatory skin disease, with an usual onset in the pediatric age. Several drugs are used in the treatment of this skin disease. Drugs as steroid, calcineurin inhibitors, and moisturizing creams are widely used in the treatment of this disease but often patients are not satisfied with the obtained results. Read More

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November 2018
2 Reads

Atypical actinobacillosis affecting hind limbs and lungs in a single beef cattle herd.

J Vet Intern Med 2018 Dec 12. Epub 2018 Dec 12.

Clinic for Ruminants, Nantes, France.

Actinobacillosis usually is a sporadic infection that affects the tongue in cattle ("wooden tongue") with possible spread to the digestive tract. Two 4-year-old Rouge-des-Prés cows from a single French beef herd were referred for chronic (2-6 months) swelling and cutaneous nodules in the distal hind limbs. In addition to cutaneous signs, physical examination disclosed cachexia, lameness, lymphadenitis of the hind limbs, and pneumonia in both cows. Read More

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December 2018
1 Read

Allergic contact connubial dermatitis caused by hair products.

Contact Dermatitis 2018 Dec 12. Epub 2018 Dec 12.

Immunology and Allergology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Espinho, Portugal.

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December 2018

Use of essential oils: A General population survey.

Contact Dermatitis 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.

Minnesota State Fair attendees >18 years old were invited to complete a 17-question, institutional review board-approved survey on EO use. The questionnaire was designed with input by experts in contact dermatitis (EW, SH) and survey methodology (NG, EW). Read More

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December 2018

Occupational contact dermatitis to isopropanol-containing disinfectant based on a genetic defect.

Contact Dermatitis 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology and Venerology, Medical University of Graz, Austria.

A 52-year-old non-atopic healthy female Caucasian developed severe hand eczema after 13 years of working as a nurse. No recent changes had occurred in her work activities. The bouts of eczema correlated with her occupational activity. Read More

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December 2018

A retrospective multicenter study of carbon-ion radiotherapy for external auditory canal and middle ear carcinomas.

Cancer Med 2018 Dec 8. Epub 2018 Dec 8.

Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.

Background: We conducted a retrospective multicenter study to assess the clinical outcomes of carbon-ion radiotherapy (CIRT) for head and neck malignancies (Japan Carbon-Ion Radiation Oncology Study Group [J-CROS] study: 1402 HN). We aimed to evaluate the safety and efficacy of CIRT in patients with external auditory canal (EAC) and middle ear (ME) carcinomas.

Methods: Thirty-one patients treated with CIRT at four Japanese institutions were analyzed. Read More

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December 2018

Methods for Assessing Mast Cell Responses to Engineered Nanomaterial Exposure.

Methods Mol Biol 2019 ;1894:31-45

Department of Pharmaceutical Sciences, Colorado Center for Nanomedicine and Nanosafety, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.

Mast cells are key effector cells in inflammatory and allergic immune responses such as asthma, rhinitis, and atopic dermatitis. Activation of mast cells leads to immediate release of preformed mediators such as histamine and proteases, which can regulate vascular permeability and the function of a number of immune and nonimmune cells. Engineered nanomaterials (ENM) have been utilized for a wide range of applications and introduced into a number of consumer products; yet the consequent increase in human exposure and any potential adverse effects have not been fully evaluated. Read More

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January 2019

Not All Rashes Are Allergic: Keratoderma Blennorrhagicum-Like Rash Masquerading as Contact Dermatitis.

Allergy Rhinol (Providence) 2018 Jan-Dec;9:2152656718811566. Epub 2018 Dec 4.

Division of Allergy and Clinical Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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December 2018

The immunosuppressant macrolide tacrolimus activates cold-sensing TRPM8 channels.

J Neurosci 2018 Dec 13. Epub 2018 Dec 13.

Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, 03550 San Juan de Alicante, Spain

TRPM8 is a polymodal, non-selective cation channel activated by cold temperature and cooling agents that plays a critical role in the detection of environmental cold. We found that TRPM8 is a pharmacological target of tacrolimus (FK506), a macrolide immunosuppressant with several clinical uses, including the treatment of organ rejection following transplants, treatment of atopic dermatitis and dry eye disease. Tacrolimus is an inhibitor of the phosphatase calcineurin, an action shared with cyclosporine. Read More

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December 2018
2 Reads

The proportion, conditions, and predictors of emergency department visits that can be potentially managed by pharmacists with expanded scope of practice.

Res Social Adm Pharm 2018 Dec 7. Epub 2018 Dec 7.

School of Pharmacy, University of Waterloo, 10 Victoria St S A, Kitchener, N2G 1C5, ON, Canada; Ontario Pharmacy Evidence Network (OPEN), School of Pharmacy, University of Waterloo, 10 Victoria St S A, Kitchener, N2G 1C5, ON, Canada.

Background: Pharmacists have been shown to be beneficial for inclusion in emergency department (ED) services; however, little has been done to assess these benefits with pharmacists having even wider scopes of practice, including limited prescribing authority.

Objectives: The aims of this study were to determine the proportion of ED visits that can potentially be managed by pharmacists, the most prevalent conditions within these cases, and the factors associated with patients presenting with such cases to the ED.

Methods: This was a retrospective quantitative cohort study using administrative databases from 2010 to 2017. Read More

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December 2018

Early Intervention is Important to Prevent Sensitization to New Allergens.

Med Sci (Basel) 2018 Dec 11;6(4). Epub 2018 Dec 11.

Department of Otolaryngology, Osaka Medical College, 2-7 Daigakumachi Takatsuki, Osaka 569-8686, Japan.

We review current management for allergic rhinitis and possible new treatments for this condition. Management of allergic rhinitis includes promotion of protective factors, avoidance of allergens, and possibly immunotherapy. In recent years, the incidence of allergic rhinitis has increased in many countries. Read More

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December 2018

Glucocorticoid Receptor Binding Inhibits an Intronic Enhancer and is Disrupted by rs4742170 (T) Allele Associated with Specific Wheezing Phenotype in Early Childhood.

Int J Mol Sci 2018 Dec 9;19(12). Epub 2018 Dec 9.

Laboratory of Intracellular Signaling in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Interleukin 33 (IL-33) is a cytokine constitutively expressed by various cells of barrier tissues that contribute to the development of inflammatory immune responses. According to its function as an alarmin secreted by lung and airway epithelium, IL-33 plays a significant role in pathogenesis of allergic disorders. IL-33 is strongly involved in the pathogenesis of asthma, anaphylaxis, allergy and dermatitis, and genetic variations in locus are associated with increased susceptibility to asthma. Read More

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December 2018
1 Read

Topical Application of JAK1/JAK2 Inhibitor Momelotinib Exhibits Significant Anti-Inflammatory Responses in DNCB-Induced Atopic Dermatitis Model Mice.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Division of Dermatology, Department of Clinical Medicine, Medical College of Yanbian University, Yanji 133000, China.

Atopic dermatitis (AD) is a chronic recurrent skin disease dominated by T-helper 2 inflammation. Momelotinib (MMB) is a novel JAK1/JAK2 inhibitor suppressing the signal transduction of multiple pro-inflammatory cytokines. Recent studies indicated that JAK inhibitor could play a therapeutic role in AD disease. Read More

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December 2018
3 Reads

Relationship of atopic dermatitis with stroke and myocardial infarction: A meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13512

Department of Neurology, Jiangxi Provincial People's Hospital.

Background: Lots of previous reports have suggested a potential association of atopic dermatitis (AD) with stroke and myocardial infarction (MI). However, the result is still controversial, Consequently, we conducted this meta-analysis to estimate the relationship of AD with Stroke and MI.

Methods: PubMed, Embase, and Web of Science databases were searched from inception to June 2018. Read More

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December 2018
2 Reads

A20 and ABIN1 suppression of a keratinocyte inflammatory program with a shared single cell expression signature in diverse human rashes.

J Invest Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, UCSF and Veterans Affairs Medical Center, San Francisco, California, USA. Electronic address:

Genetic variation in the NFκB inhibitors, ABIN1 and A20, increase risk for psoriasis. While critical for hematopoietic immune cell function, these genes are believed to additionally inhibit psoriasis by dampening inflammatory signaling in keratinocytes. We dissected ABIN1 and A20's regulatory role in human keratinocyte inflammation using an RNA-seq based comparative genomic approach. Read More

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December 2018

Adaptation of a skin sensitization assay to a chemically defined culture.

Toxicol In Vitro 2018 Dec 10. Epub 2018 Dec 10.

Department of Science and Technology, Science and Technology Institute, Federal University of São Paulo (UNIFESP), São José dos Campos, SP, Brazil; Rua Talim, 330, Vila Nair, São José dos Campos, SP CEP: 04021-001, Brazil.

There are currently three in vitro methods adopted by the Organization for the Economic Co-operation and Development for testing chemicals based on the third key event of the skin sensitization adverse outcome pathway, the activation of dendritic cells. All of them use culture medium supplemented with fetal bovine serum (FBS), which brings technical disadvantages and animal welfare concerns. The objective of this study was to analyze the possibility of eliminating the use of FBS in the human Cell Line Activation Test (h-CLAT). Read More

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December 2018

Development of new epoxy resin monomers - A delicate balance between skin allergy and polymerization properties.

Chem Res Toxicol 2018 Dec 13. Epub 2018 Dec 13.

Epoxy resin monomers (ERMs) are used as building blocks for thermosetting polymers in applications where strong, flexible, and light-weight materials are required. Most epoxy resins are polymers of diglycidyl ether of bisphenol A (DGEBA). It is highly allergenic and causes occupational allergic contact dermatitis and contact allergy in the general population. Read More

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December 2018

Authors:

Arerugi 2018 ;67(10):1414-1415

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January 2018

[EARLY INTERVENTION FOR THE DEVELOPMENT OF ATOPIC DERMATITIS].

Authors:
Kenta Horimukai

Arerugi 2018 ;67(10):1405-1411

The Jikei University Katsushika Medical Center.

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January 2018

[THE BRIEF COMMENTARY ON GUIDELINES FOR THE MANAGEMENT OF ATOPIC DERMATITIS 2018].

Authors:
Hidehisa Saeki

Arerugi 2018 ;67(10):1388-1393

Department of Dermatology, Nippon Medical School.

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January 2018

Topical anti-inflammatory and anti-oxidative effects of porcine placenta extracts on 2,4-dinitrochlorobenzene-induced contact dermatitis.

BMC Complement Altern Med 2018 Dec 12;18(1):331. Epub 2018 Dec 12.

Department of Biomedical Science and Engineering, Konkuk Institute of Technology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, South Korea.

Background: The placenta is a reservoir enriched with growth factors, hormones, cytokines and minerals. While several beneficial effects of placenta extracts on wound healing, anti-aging and anti-inflammatory responses have been reported, relatively limited mechanistic exploration has been conducted to date. Here, we provide compelling evidence of anti-inflammatory and anti-oxidative activities of porcine placenta extracts (PPE) against contact dermatitis in vivo. Read More

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December 2018

Interdisciplinary and multiprofessional outpatient secondary individual prevention of work-related skin diseases in the metalworking industry: 1-year follow-up of a patient cohort.

BMC Dermatol 2018 Dec 12;18(1):12. Epub 2018 Dec 12.

Department of Dermatology, Klinikum Dortmund gGmbH, Beurhausstr. 40, 44137, Dortmund, Germany.

Background: In Germany, work-related skin diseases are predominant within the spectrum of reported occupational diseases. Metal workers are among the high-risk professions. Offering effective prevention programs to affected patients is of utmost importance to avoid deterioration of the disease and job loss. Read More

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December 2018

Skin sensitization: Uncertainties, challenges, and opportunities for improved risk assessment.

Contact Dermatitis 2018 Dec 7. Epub 2018 Dec 7.

Unilever Safety and Environmental Assurance Centre, Bedford, UK.

At the ESCD congress held in Manchester in 2016, a session was organized to encourage more dialogue between clinicians with expertise in skin sensitization and toxicologists seeking to provide effective risk assessment to prevent human health issues. That session focused on the remaining uncertainties regarding the induction and regulation of skin sensitization in humans, and the opportunities and challenges associated with the refinement and improvement of risk assessment methodologies. This short article, prompted by those discussions, debates what the authors regard as being among the most important and most intriguing uncertainties about skin sensitization and allergic contact dermatitis in humans, and the most significant opportunities for improving risk assessment. Read More

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December 2018

Risk Factors for Deterioration of the Clinical Condition of Cull Dairy Cows During Transport to Slaughter.

Front Vet Sci 2018 22;5:297. Epub 2018 Nov 22.

Department of Animal Science, Aarhus University, Tjele, Denmark.

Cull dairy cows are typically transported to slaughter by road. Across different types of cattle, road transport is recognized as stressful. Cull dairy cows may have different injuries or weaknesses and may thus be more vulnerable to transport stress than other types of cattle. Read More

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November 2018

Food Allergy and Asthma: Is There a Link?

Curr Treat Options Allergy 2018 1;5(4):436-444. Epub 2018 Oct 1.

2Erasmus Medical Center, Department of Internal Medicine, Section of Allergology, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Purpose Of Review: To describe and understand the links and interactions between food allergy and asthma.

Recent Findings: Food allergy and asthma are characterized by an increasing prevalence. Moreover, food allergy and asthma often coexist. Read More

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October 2018

Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases.

World Allergy Organ J 2018 3;11(1):35. Epub 2018 Dec 3.

1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova str. 32, Moscow, Russian Federation 119991.

Background: In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and sIgG4 patterns in the most common allergic disorders: bronchial asthma, upper airway disorders and atopic dermatitis.

Methods: In this study a screening analysis of blood serum samples from 673 patients aged from 6 months to 17 years with different allergic entities was performed on microarrays. Read More

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December 2018
2 Reads

Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma.

Front Immunol 2018 20;9:2694. Epub 2018 Nov 20.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Allergic diseases including asthma, chronic rhinosinusitis, and atopic dermatitis are common conditions worldwide. While type 2 immune responses induced by T-cells significantly cause allergic inflammation, the recently identified group two innate lymphoid cells (ILC2s) are emerging as critical players in the development of allergy. Upon allergen exposure, ILC2s are rapidly activated by cytokines released by epithelial cells. Read More

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November 2018
2 Reads

Contact urticaria with anaphylaxis to chlorocresol, chloroxylenol and thiourea.

Contact Dermatitis 2018 Dec 6. Epub 2018 Dec 6.

East Kent Hospitals University NHS Foundation Trust, Canterbury, UK.

Contact urticaria (CU) is defined as an immediate wheal-and-flare skin reaction following direct contact with a protein or chemical agent . CU has been described in association with numerous chemicals, including preservatives, antiseptics, fragrances and medicaments . CU syndrome ranges from localised urticaria (stage 1) to anaphylactoid reactions with shock (stage 4) . Read More

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December 2018

Measurement of Nocturnal Scratching in Patients with Pruritus Using a Smartwatch: Initial Clinical Studies with the Itch Tracker App.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Future Design, Maruho Co Ltd, 531-0071 Osaka, Japan.

Three clinical studies were conducted to test a newly-developed app for smartwatches, which included an algorithm to measure nocturnal scratching using acceleration data. The first study in 5 patients with atopic dermatitis demonstrated high reliability of the app for measurement of scratching compared with video monitoring (positive predictive value 90.2 ± 6. Read More

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December 2018