3,349 results match your criteria Dermatitis Herpetiformis


Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis.

Acta Derm Venereol 2022 May 16;102:adv00713. Epub 2022 May 16.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Dermatitis herpetiformis is a blistering autoimmune skin disease, and a cutaneous manifestation of coeliac disease. The burden of coeliac disease is increased especially in females, but studies concerning sex differences in patients with long-term treated dermatitis herpetiformis are scarce. This questionnaire study compared adherence to a gluten-free diet, clinical symptoms and well-being between females and males in a cohort of 237 long-term treated (median 24 years) patients with dermatitis herpetiformis. Read More

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Etiopathogenesis of dermatitis herpetiformis.

Postepy Dermatol Alergol 2022 Feb 28;39(1):1-6. Epub 2022 Feb 28.

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland.

Dermatitis herpetiformis is a rare chronic, autoimmune bullous disease linked to gluten sensitivity with intense pruritus and characteristic skin eruptions. Etiopathogenesis is complex and not fully understood. It is currently considered to be a specific cutaneous manifestation of celiac disease. Read More

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February 2022

Oral immune-mediated disorders with malignant potential/association: An overview.

Dis Mon 2022 Mar 22:101349. Epub 2022 Mar 22.

College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT, United States. Electronic address:

A group of oral disorders or conditions, which may result from, or could be triggered by an abnormality in the normal immune response of an individual are known as oral immune-mediated disorders. Some of these disorders have malignant potential, while others are associated with malignancy. In this overview, we will discuss a few of the oral diseases (such as oral lichen planus, primary Sjogren's syndrome, systemic lupus erythematosus, dermatitis herpetiformis, and linear immunoglobulin A bullous dermatosis, to name a few), which are caused due to irregularity in the immune system and are either associated with malignancy or capable of undergoing malignant transforming, thereby increasing the morbidity and mortality rate. Read More

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Antibody Responses to Transglutaminase 3 in Dermatitis Herpetiformis: Lessons from Celiac Disease.

Int J Mol Sci 2022 Mar 8;23(6). Epub 2022 Mar 8.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, FI-33520 Tampere, Finland.

Dermatitis herpetiformis (DH) is the skin manifestation of celiac disease, presenting with a blistering rash typically on the knees, elbows, buttocks and scalp. In both DH and celiac disease, exposure to dietary gluten triggers a cascade of events resulting in the production of autoantibodies against the transglutaminase (TG) enzyme, mainly TG2 but often also TG3. The latter is considered to be the primary autoantigen in DH. Read More

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[Dermatitis herpetiformis and celiac disease].

Rev Med Chil 2021 Sep;149(9):1330-1338

Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile.

Dermatitis herpetiformis is an autoimmune chronic blistering disease, considered a skin manifestation of celiac disease. Being both conditions multifactorial, they share some genetic traits and pathogenic mechanisms, which are responsible for the typical skin and gastrointestinal manifestations. In dermatitis herpetiformis, skin and other lesions heal after gluten-free diet and reappear shortly after its reintroduction to complete diet. Read More

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September 2021

Fibrillary "Fern-Like" Immunoglobulin A Deposition in Dermatitis Herpetiformis.

Am J Dermatopathol 2022 05;44(5):389-390

Department of Dermatology, UConn Health, Farmington, CT.

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Clinical Treatment Study of Secondary Multiple Squamous Cell Carcinoma with Psoriasis Vulgaris.

J Oncol 2022 6;2022:9529681. Epub 2022 Jan 6.

Department of Dermatology, Cangzhou Central Hospital, Cangzhou, Hebei 061000, China.

Dermatologic diseases are the fourth most frequent nonfatal common illness, yet they have a psychological, economical, and professional burden that is comparable to or larger than other chronic conditions. From a survey in China of 6 provinces, the overall prevalence of psoriasis with squamous cell carcinoma was 0.47%. Read More

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January 2022

Association between celiac disease and vitiligo: A review of the literature.

World J Clin Cases 2021 Dec;9(34):10430-10437

Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Key Laboratory of Dermatology Research, Urumqi 830001, Xinjiang Uygur Autonomous Region, China.

Celiac disease (CD) is an autoimmune intestinal disease caused by the intake of gluten-containing cereals and their products by individuals with genetic susceptibility genes. Vitiligo is a commonly acquired depigmentation of the skin; its clinical manifestation are skin patches caused by localized or generalized melanin deficiency. Both diseases have similar global incidence rates (approximately 1%) and are associated to similar diseases, including autoimmune bullous disease, inflammatory bowel disease, autoimmune thyroiditis, autoimmune gastritis, and type 1 diabetes. Read More

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December 2021

Diagnostics for Dermatologic Diseases with Autoantibodies.

J Appl Lab Med 2022 01;7(1):165-196

Immunodermatology Laboratory, Department of Dermatology, University of Utah, UT, USA.

Background: Dermatologic diseases with autoantibodies were recognized early as autoimmunity became accepted as a pathogenic immunologic concept. Laboratory testing to identify disease-defining autoantibodies and investigate their role in pathophysiology has evolved since.

Content: Blistering dermatologic diseases, profiled by autoantibody production, target epithelial components critical in cell-cell and cell-matrix adhesion, resulting in epithelial separation and other characteristic features of the disorders. Read More

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January 2022

Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study.

BMJ Open 2021 12 31;11(12):e053133. Epub 2021 Dec 31.

Skin and Allergy Hospital, Helsinki, Uusimaa, Finland.

Objectives: Many comorbidities are associated with adult asthma and may exacerbate the asthma burden of disease. This study aims to investigate the risk for major oral diseases or oral-manifesting diseases in asthmatic compared with non-asthmatic adults.

Design: We conducted a population-based matched cohort study with a 13. Read More

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December 2021

Impetigo herpetiformis successfully treated with brodalumab.

J Dermatol 2022 04 27;49(4):e149-e150. Epub 2021 Dec 27.

Department of Dermatology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

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Acrodystrophic axonal polyneuropathy with celiac disease: a case report.

J Med Case Rep 2021 Dec 18;15(1):615. Epub 2021 Dec 18.

S.M. Kirov Military Medical Academy, Akademika Lebedeva Street, 6., Saint Petersburg, 194044, Russia.

Background: Patients with celiac disease present with not only gastrointestinal symptoms but also extraintestinal manifestations such as anemia, osteopathy, dermatitis herpetiformis, and celiac neuropathy. Despite a fairly wide range of celiac neuropathies, we report a case of the acrodystrophic variant of celiac polyneuropathy, which has not been previously described.

Case Presentation: A 41-year-old Ukrainian male suffered from symmetric, sensorimotor axonal polyneuropathy and encephalopathy associated with celiac disease, which is characterized by severe trophic disorders in the lower extremities (trophic ulcers, hyperkeratosis, and anhidrosis). Read More

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December 2021

THE MANAGEMENT OF DERMATITIS HERPETIFORMIS BY THE GASTROENTEROLOGIST. A SERIES OF CASES.

Arq Gastroenterol 2021 Oct-Dec;58(4):429-432

Universidade Federal do Paraná, Setor de Ciências da Saúde, Curitiba, PR, Brasil.

Background: Dermatitis herpetiformis (DH) is considered a skin celiac disease (CD). The individuals can be seen by primary care professionals or by dermatologists that could refer the patient to a gastroenterologist.

Objective: The study aimed to investigate the clinical profile of patients diagnosed with DH and referred to a gastroenterologist and evaluate the treatment response. Read More

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December 2021

Dermatitis herpetiformis triggered by iodine contrast media.

J Eur Acad Dermatol Venereol 2022 05 20;36(5):e348-e350. Epub 2021 Dec 20.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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The Gluten-Free Diet for Celiac Disease and Beyond.

Nutrients 2021 Nov 9;13(11). Epub 2021 Nov 9.

Section of Pediatric Gastroenterology, Department of Pediatrics and Child Health, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3A 1S1, Canada.

The gluten-free diet (GFD) has gained popularity beyond its main medical indication as the treatment for gluten-induced immune-mediated disorders such as celiac disease (CD), dermatitis herpetiformis, gluten ataxia, wheat allergy, and non-celiac gluten sensitivity. However, the diet carries some disadvantages such as elevated costs, nutritional deficiencies, and social and psychological barriers. The present work aims to review indications, proven benefits, and adverse events of a gluten-free diet. Read More

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November 2021

Dermatitis herpetiformis in a child with Wiskott-Aldrich syndrome: A rare occurrence.

Pediatr Blood Cancer 2022 04 22;69(4):e29459. Epub 2021 Nov 22.

Division of Pediatric Immunology and Rheumatology, Department of Pediatrics, Aster CMI Hospital, Bangalore, Karnataka, India.

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Nutrition and bullous diseases.

Clin Dermatol 2021 Nov 19. Epub 2021 Nov 19.

Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut, USA. Electronic address:

Although relatively uncommon, autoimmune bullous diseases carry the risk of increased mortality and can significantly impact quality of life. This group of diseases is broad and encompasses subepidermal conditions such as bullous pemphigoid, cicatricial pemphigoid, epidermolysis bullosa acquisita, dermatitis herpetiformis, and linear IgA bullous dermatosis, as well as intraepidermal conditions such as pemphigus and its variants. The pathophysiology of each condition is incompletely understood but broadly involves the formation of autoantibodies targeting skin adhesion proteins, a process that relies on a complex interplay between a dysregulated immune system, genetic predisposition, and environmental factors. Read More

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November 2021

Underlying coeliac disease in a case of cerebellar ataxia with unknown etiology.

Arch Clin Cases 2019 27;6(1):22-25. Epub 2021 Oct 27.

Department of Pathology, Pt. B.D. Sharma University of Health Sciences, Rohtak (Haryana), India.

Celiac disease is an immune mediated enteropathy in susceptible individuals as a response to gluten containing diets based on wheat, oat, rye and maize. It clinically presents with malabsorption syndrome along with a myriad of extraintestinal manifestations such as anemia, osteoporosis, dermatitis herpetiformis, peripheral neuropathies, ataxia and cognitive impairment. Although the prevalence of these extraintestinal features range from 1 to 15% in these patients, their presence in the absence of intestinal manifestations is very rare. Read More

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October 2021

[Stiff person syndrome associated with dermatitis herpetiformis: a case report].

Pan Afr Med J 2021 9;40:27. Epub 2021 Sep 9.

Service de Médecine Interne, Hôpital Arrazi Centre Hospitalier Universitaire Mohamed VI, Marrakech, Maroc.

Stiff person syndrome (SPS) is a rare disease affecting the central nervous system which can be autoimmune, paraneoplastic or idiopathic in origin. Its typical classic presentation is characterized by progressive stiffness of the trunk and limbs, associated with spasms. The diagnosis is supported by the existence of continuous and spontaneous muscle activity on electroneuromyogram detection, the presence of serum anti-GAD antibodies, and a response to benzodiazepines. Read More

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November 2021

Frequency of Cutaneous Disorders in Patients With Celiac Disease.

Cureus 2021 Sep 21;13(9):e18148. Epub 2021 Sep 21.

Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK.

Background and objective Celiac disease is an autoimmune multisystem disorder that is triggered by dietary gluten sensitivity in genetically susceptible individuals. It presents with extraintestinal cutaneous manifestations including dermatitis herpetiformis (DH), atopic dermatitis, psoriasis, urticaria, and alopecia areata. Due to the insufficient availability of data, this study aimed to estimate the frequency of cutaneous manifestation in a Pakistani population with celiac disease. Read More

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September 2021

The accuracy of diagnostic indicators for coeliac disease: A systematic review and meta-analysis.

PLoS One 2021 25;16(10):e0258501. Epub 2021 Oct 25.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Background: The prevalence of coeliac disease (CD) is around 1%, but diagnosis is challenged by varied presentation and non-specific symptoms and signs. This study aimed to identify diagnostic indicators that may help identify patients at a higher risk of CD in whom further testing is warranted.

Methods: International guidance for systematic review methods were followed and the review was registered at PROSPERO (CRD42020170766). Read More

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November 2021

Skin Manifestations and Coeliac Disease in Paediatric Population.

Nutrients 2021 Oct 15;13(10). Epub 2021 Oct 15.

Pediatric Unit, NESMOS Department, Faculty of Medicine & Psychology, Sapienza University of Rome, Sant'Andrea University Hospital, 00185 Rome, Italy.

Celiac disease (CD) is an immune-mediated enteropathy caused by gluten ingestion, affecting approximately 1% of the worldwide population. Extraintestinal symptoms may be present as the first signs of CD, years before the CD diagnosis is made. A great variety of extraintestinal manifestations may be associated with CD. Read More

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October 2021

Assessment of Clinical and Laboratory Use of the Cutaneous Direct Immunofluorescence Assay.

JAMA Dermatol 2021 Nov;157(11):1343-1348

Massachusetts General Physician Organization Dermatopathology Associates, Newton, Massachusetts.

Importance: Dermatologists submit direct immunofluorescence (DIF) biopsies on a daily basis, using an assay detecting immunoreactant deposition with a panel that has traditionally comprised immunoglobulin (Ig) G, IgA, IgM, C3, and fibrin, with or without albumin antibodies.

Objectives: To evaluate and compare the frequency of immunoreactants in DIF biopsies submitted over an 8-year period and assess use by dermatologists based on clinical impression.

Design, Setting, And Participants: A quality improvement study was conducted in a community outreach reference laboratory associated with a large academic medical center. Read More

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November 2021

Clinical Application of Pharmacogenetic Markers in the Treatment of Dermatologic Pathologies.

Pharmaceuticals (Basel) 2021 Sep 6;14(9). Epub 2021 Sep 6.

Pharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, Spain.

Dermatologic pathologies are the fourth most common cause of non-fatal disease worldwide; however, they produce a psychosocial, economic, and occupational impact equal to or greater than other chronic conditions. The most prevalent are actinic keratosis, followed by basal-cell carcinoma, in a lesser proportion acne vulgaris, psoriasis, and hidradenitis suppurativa, among others, and more rarely dermatitis herpetiformis. To treat actinic keratosis and basal-cell carcinoma, 5-fluorouracil (5-FU) 0. Read More

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September 2021

Role of nutritional supplements in selected dermatological disorders: A review.

J Cosmet Dermatol 2022 Jan 26;21(1):85-98. Epub 2021 Sep 26.

Department of Dermatology, Venereology and Leprosy, Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India.

Background: While a plethora of literature continues to be published on the role of nutritional agents both in lay press and indexed journals, the data is not on a firm footing and leaves the dermatologist in a quandry and the patient confused. The various agents include vitamins, minerals, amino acids, antioxidants, diets & gluten. A proper knowledge of the role of nutritional supplements in dermatological diseases can be a useful tool in advising the patients and in certain cases ameliorating the disorder. Read More

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January 2022

Editorial: Lessons on T-Cells and Immune-Targeting Therapeutics in Coeliac Disease.

Front Immunol 2021 3;12:756087. Epub 2021 Sep 3.

Wesley Medical Research - The Wesley Hospital, Auchenflower, QLD, Australia.

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February 2022

Persistent Skin Symptoms after Diagnosis and on a Long-term Gluten-free Diet in Dermatitis Herpetiformis.

Acta Derm Venereol 2021 Sep 22;101(9):adv00555. Epub 2021 Sep 22.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, FIN-33014 Tampere, Finland. E-maill:

Dermatitis herpetiformis is a cutaneous manifestation of coeliac disease treated with a gluten-free diet. However, the itching and blistering rash alleviates slowly after gluten withdrawal and occasionally persists despite a long-term gluten-free diet. This study investigated the prevalence and factors associated with prolonged (i. Read More

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September 2021

A Case of Possible Concurrence of Dermatitis Herpetiformis and Linear Immunoglobulin A / Immunoglobulin G Bullous Dermatosis.

Acta Dermatovenerol Croat 2021 Jul;29(2):116-117

Satoko Minakawa, MD, PhD, Department of Dermatology Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan;

Dear Editor, Linear immunoglobulin (Ig) A bullous dermatosis (LABD), one subtype of subepidermal autoimmune bullous skin diseases (AIBDs), is characterized by linear deposit of only IgA along the basement membrane zone (BMZ) on direct immunofluorescence (DIF) (1,2). Patients showing linear deposits of both IgA and IgG are diagnosed with linear IgA/IgG bullous dermatosis (LAGBD) (3,4). Dermatitis herpetiformis (DH) is another type of subepidermal AIBD characterized by clinically pruritic erythematous skin lesions with vesicles on the elbows, knees, and buttocks with granular IgA deposits of IgA by DIF (5). Read More

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