116,631 results match your criteria Dermatitis Herpetiformis


Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

Glycosaminoglycans (GAGs) are linear, highly negatively charged carbohydrate chains present in connective tissues. Chondroitin sulfate (CS) and heparin (Hep) are also found in the numerous secretory granules of mast cells (MC), tissue immune cells involved in allergic and inflammatory reactions. CS and Hep may inhibit secretion of histamine from rat connective tissue MC, but their effect on human MC remains unknown. Read More

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December 2018

The Prevalence of Atopic Dermatitis and Chronic Spontaneous Urticaria are Associated with Parental Socioeconomic Status in Adolescents in China.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Xiangya Hospital, 410008 Changsha, China.

The association of atopic dermatitis and chronic spontaneous urticaria with socioeconomic status has been little studied. The aim of this study was to investigate the prevalence of skin diseases and their association with socioeconomic status in adolescents in China. A cross-sectional study was conducted at a comprehensive university. Read More

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December 2018
3 Reads

Novel Paranannizziopsis species in a Wagler's viper (Tropidolaemus wagleri), tentacled snakes (Erpeton tentaculatum), and a rhinoceros snake (Rhynchophis boulengeri) in a zoological collection.

Med Mycol 2018 Dec 6. Epub 2018 Dec 6.

Mycology Unit, Facultat de Medicina i Ciències de la Salut and IISPV, University Rovira i Virgili, Reus, Spain.

We report several cases of fungal infections in snakes associated with a new species within the genus Paranannizziopsis. Three juvenile Wagler's vipers (Tropidolaemus wagleri) presented with skin abnormalities or ulcerative dermatitis, and two snakes died. Histologic examination of skin from the living viper revealed hyperplastic, hyperkeratotic, and crusting epidermitis with intralesional fungal elements. Read More

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December 2018
3 Reads

Letter to the Editor: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. JEADV 2018, 32, 850-878. doi.org/10.1111/jdv.14888.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Head Research & Head Outpatient Clinic, Department of Dermatology, University Hospital Zürich, Switzerland.

We read with interest and with full consent the new consensus-based European guidelines for the treatment of atopic eczema, Part II . However, we would like to comment on the section on microbial textiles where the recommendation to use silk garments with permanent antimicrobial in the management of children with moderate to severe eczema is raised. On the basis of an UK multicenter clinical trial which seemed to show that silk garments with permanent antimicrobial were ineffective in the treatment of children with atopic eczema, the guidelines deny now any clinical benefit of AEGIS-coated silk textiles in children with atopic eczema and this contrary to the previous two guidelines . Read More

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December 2018
2 Reads

Methotrexate in atopic eczema. Comments to: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Allergy and Clinical Immunology Department, Lyon Sud University Hospital, Pierre Bénite, University of Lyon, France.

The recent European guidelines for the treatment of atopic eczema (AE) are a thorough overview of therapeutic opportunities for AE. Among the systemic treatments, we propose to bring further insights on methotrexate (MTX) use in adult AE patients. This article is protected by copyright. Read More

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December 2018
2 Reads

Reply to a correspondence addressing the European guideline for treatment of atopic eczema, functional textiles and the CLOTHES trial.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Department Dermatology and Allergy Biederstein, Technische Universität München Munich, Germany and Christine Kühne-Center for Allergy Research and Education (CK-CARE)Davos.

We have read with interest the respectfully written correspondence by Wüthrich et al. regarding antimicrobial silk textiles for atopic dermatitis (AD) (1). Though it was submitted as a comment to the European consensus-based S2k guidelines on treatment of atopic eczema (2,3), it is discussing in 70% of its length the CLOTHES trial - published in two non-JEADV-publications which we have neither designed nor authored (4,5). Read More

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December 2018
2 Reads

Phenotypes of atopic dermatitis identified by cluster analysis in early childhood.

J Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Atopic dermatitis is a chronic, relapsing, inflammatory skin disease that usually appears in early childhood and develops into a heterogeneous disease during childhood. The clinical course and treatment for atopic dermatitis can differ according to its phenotype and/or endotype. This study aimed to identify clinical phenotypes of atopic dermatitis in early childhood. Read More

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December 2018
2 Reads

Late cutaneous B-Cell pseudolymphoma after an upper-lid gold weight implant.

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Hospital Universitario Príncipe de Asturias, Madrid, Spain.

Upper eyelid gold weight implants are an established tool in the symptomatic treatment of lagophthalmos, the inability to close your eyes completely. Complications associated to this procedure are infrequent. When noted, non-infectious inflammatory reactions corresponding to type IV hypersensitivity reactions are resolved with the removal of the implant. Read More

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December 2018
1 Read

European Surveillance System on Contact Allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis.

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.

Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.

Objective: To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Read More

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December 2018
2 Reads

[Immunoadsorption in dermatology].

Hautarzt 2018 Dec 5. Epub 2018 Dec 5.

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Autoimmmune bullous diseases are mediated by pathogenetically relevant autoantibodies against components of the epidermis and/or superficial mucous membranes (in pemphigus) and structural proteins of the dermal-epidermal junction (in pemphigoid diseases). Using immunoadsorption (IA), an already well-established procedure in cardiac and rheumatic disorders, antibodies can be removed from the plasma. At present, most data on the adjuvant use of IA in dermatology are derived from patients with severe and/or refractory pemphigus vulgaris or pemphigus foliaceus and also from patients with pemphigoid diseases. Read More

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December 2018

Tri-culture system for pro-hapten sensitizer identification and potency classification.

Technology (Singap World Sci) 2018 Jun 29;6(2):67-74. Epub 2018 Jun 29.

Department of Biomedical Engineering, Rutgers, the State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA.

Allergic contact dermatitis (ACD) is an inflammatory disease that impacts 15-20% of the general population and accurate screening methods for chemical risk assessment are needed. However, most approaches poorly predict pre- and pro-hapten sensitizers, which require abiotic or metabolic conversion prior to inducing sensitization. We developed a tri-culture system comprised of MUTZ-3-derived Langerhans cells, HaCaT keratinocytes, and primary dermal fibroblasts to mimic the cellular and metabolic environments of skin sensitization. Read More

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June 2018
2 Reads

Wash-Line Dermatitis: A Diagnostic Clue.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):12. Epub 2018 Oct 1.

Dr. Jacob is is a Professor of Dermatology in the Dermatology Department at Loma Linda University in Loma Linda, California.

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October 2018

Allergic Contact Dermatitis and Autoeczematization to Proctosedyl® Cream and Proctomyxin® Cream.

Case Rep Dermatol 2018 Sep-Dec;10(3):238-246. Epub 2018 Oct 24.

Department of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Proctosedyl® and Proctomyxin® are two commonly prescribed hemorrhoid therapies. Their topical application to the perianal region may be complicated by a local allergic contact dermatitis and subsequent autoeczematization reaction. We present three cases of an autoeczematization (ID) reaction to varying topical allergens found in Proctosedyl®/Proctomyxin®. Read More

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October 2018

Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.

Cell Death Dis 2018 Dec 5;9(12):1181. Epub 2018 Dec 5.

Department of Immunology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Mechanical damage on the skin not only affects barrier function but also induces various immune responses, which trigger or exacerbate skin inflammation. However, how mechanical damage-induced skin inflammation is regulated remains incompletely understood. Here, we show that keratinocytes express the long-chain fatty-acid elongase Elovl6. Read More

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December 2018
1 Read

The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA).

J Toxicol Sci 2018 ;43(12):741-749

Department of Dermatology, Tohoku University Graduate School of Medicine.

In all current in vitro skin sensitisation assays, DMSO is used to dissolve water-insoluble chemicals. However, our previous study suggested the superiority of the modified IL-8 Luc assay (mIL-8 Luc), in which X-VIVO 15 is used to dissolve chemicals, over the original assay using DMSO (oIL-8 Luc). In this study, to confirm the superiority of the mIL-8 Luc, we first increased the number of chemicals examined and demonstrated the superiority of the mIL-8 Luc, in which the mIL-8 Luc provided 87. Read More

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January 2018

Probable Roles of Coagulation Cascade and Fibrinolysis System in the Development of Allergic Rhinitis.

Am J Rhinol Allergy 2018 Dec 6:1945892418816015. Epub 2018 Dec 6.

3 Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Background: Dysregulation of the coagulation cascade and fibrinolysis system may play an etiologic role in many diseases. Allergic diseases such as bronchial asthma, atopic dermatitis, and conjunctivitis are also associated with fibrin accumulation caused by a change in hemostasis. However, only a few studies have dealt with the relationship between allergic rhinitis (AR) and the coagulation system. Read More

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December 2018

Clinical and instrumental evaluation of the efficacy of an emollient cream and a cleansing cream in the management of mild to moderate adulthood atopic dermatitis.

G Ital Dermatol Venereol 2018 12;153(6):855-859

Department of Clinical Pathology Cristo Re Hospital, Rome, Italy.

Background: Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disorder which may persist or directly start in adults. This is an open-label prospective study to clinically and instrumentally evaluate the effects of an emollient glycerin and paraffin-based cream and a gentle refatting cleanser in the management of mild to moderate adulthood AD.

Methods: Fifty adult patient with mild to moderate AD were recruited at the Professional Dermatology and Allergology Outpatient Clinic of the San Gallicano Dermatological Institute of Rome, between November 2016 and January 2018. Read More

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December 2018

Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

Background: Adenoid cystic carcinoma (ACC) are more common in the minor salivary glands (MiSGs) than the major salivary glands, and are characterized by slow tumor progression and frequently local recurrence. The main treatment option is surgery followed by combined radiotherapy.

Methods: A retrospective analysis contained 67 patients with ACC of MiSGs in the oral cavity who underwent surgery followed by radiotherapy. Read More

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December 2018
2 Reads

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.

Ann Allergy Asthma Immunol 2018 Nov 30. Epub 2018 Nov 30.

The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA; Department of Dermatology, the Laboratory for Inflammatory Skin Diseases and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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November 2018

Preventing the development of asthma: stopping the allergic march.

Curr Opin Allergy Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.

Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: To describe important precipitants of asthma and allergic disease, to highlight the links between these triggers and modifications within the immune system, and to examine innovative research regarding asthma prevention with focus on attenuating the atopic march.

Recent Findings: Allergen avoidance, allergen immunotherapy, IgE antagonists, prevention and treatment of respiratory infections, as well as management of gastrointestinal and respiratory dysbiosis have been considered as strategies in asthma prevention. Antenatal vitamin D supplementation in expectant mothers and aggressive control of atopic dermatitis to prevent the development of other allergic conditions were carefully studied as well. Read More

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November 2018

Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Dermatology, University of Alabama at Birmingham (UAB), Birmingham, AL.

Background: Studies have begun to investigate the complex relationship between host and microorganisms in non-infectious pathologies such as acne, atopic dermatitis, and psoriasis. Though the skin is exposed to environmental stressors such as ultraviolet radiation (UVR), no studies exist examining the effects of both UVA and UVB on the skin microbiome.

Objective: To test the effect of UVA and UVB on human skin microbiome. Read More

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December 2018

Neurocognitive function in moderate-severe pediatric atopic dermatitis: A case-control study.

Pediatr Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Division of Dermatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois.

Background/objectives: Epidemiological studies have shown an increased prevalence of attention deficit hyperactivity disorder (ADHD) in children with atopic dermatitis (AD), but many of the features of ADHD may occur as a result of the poor sleep and itch distraction associated with AD.

Methods: A case-control study was performed in children aged 6-17 years with moderate/severe AD compared with age-/sex-matched healthy controls. Participants were screened for ADHD using Vanderbilt assessments. Read More

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December 2018

Neonatal skin care: Developments in care to maintain neonatal barrier function and prevention of diaper dermatitis.

Pediatr Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Skin Health Alliance, London, UK.

Background: Understanding the importance of the barrier function of the skin of preterm and term neonates is crucial in effective neonatal skin and diaper care. This literature search aimed to review the development of different practices in neonatal care to maintain skin barrier function, in turn preventing diaper dermatitis.

Methods: We performed two quantitative literature searches of English language studies: an initial literature search of studies published in the last 5 years was conducted using Cinahl, Medline, Embase, British Nursing Index, and DelphiS, followed by a second search of publications from 1990 to 2017 using the National Institute of Clinical Excellence Health Databases Advanced Search using key words, synonyms, and Boolean phrasing. Read More

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December 2018

CORRIGENDUM.

Authors:

Contact Dermatitis 2019 Jan;80(1):76

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January 2019

Tertiary prevention of occupational skin diseases: Prevalence of allergic contact dermatitis and pattern of patch test results.

Contact Dermatitis 2019 Jan 28;80(1):35-44. Epub 2018 Aug 28.

Lower-Saxonian Institute of Occupational Dermatology at the Georg-August University, Göttingen, Germany, and at the University of Osnabrück, Osnabrück, Germany.

Background: Allergic contact dermatitis (ACD) is one of the most common occupational skin diseases (OSDs). Its prevalence and the causative allergens differ between occupations.

Objectives: To evaluate the prevalence of ACD and the pattern of patch test results of patients taking part in a tertiary individual prevention programme (TIP) for OSD in Germany. Read More

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January 2019

Microexamination.

Contact Dermatitis 2019 Jan;80(1):74-75

St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

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January 2019
1 Read

Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model.

Arch Dermatol Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Gyunggi-do, 16419, Republic of Korea.

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is not fully understood. Defects in skin barrier function and dysregulation of the Th2 immune response are thought to be pivotal in AD pathogenesis. In this study, we used keratinocytes and AD-like skin equivalent models using Th2 cytokines IL-4 and IL-13. Read More

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November 2018

Outcome and toxicity of intensity-modulated radiotherapy with simultaneous integrated boost in patients with pharyngo-laryngeal cancer.

Clin Transl Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiation Oncology, GenesisCare, Madrid, Spain.

Purpose: The present work aims at evaluating intensity-modulated radiation therapy with simultaneous integrated boost (IMRT-SIB) in squamous cell carcinomas (SCC) of the larynx and hypopharynx.

Methods/patients: We performed a single institutional retrospective analysis on 116 pharyngo (29%)-laryngeal (71%) SCC patients (93% male) treated with IMRT-SIB to 66-69.96 Gy in 33 fractions between 2008 and 2016. Read More

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November 2018

Tinea Corporis Due to Trichophyton erinacei Probably Transmitted from a Hedgehog.

Med Mycol J 2018 ;59(4):E77-E79

Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine.

A 26-year-old female homemaker presented with an approximately 2-month history of an erythematous lesion with agminated seropapules in the right popliteal fossa associated with scales and crusts. The lesion was initially treated as contact dermatitis, but there was no improvement. KOH examination revealed filamentous fungi. Read More

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January 2018

Mesenchymal stem cells: a potential therapy for canine atopic dermatitis?

Vet Rec 2018 Dec;183(21):651-653

DVM, Residency ACVD / ECVD completed, Tierklinik Stuttgart Plieningen, Hermann-Fein-Strasse 15, 70599 Stuttgart, Germany.

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December 2018

Self-reported hypersensitivity and allergy to foods amongst Mexican adolescents: Prevalence and associated factors.

Allergol Immunopathol (Madr) 2018 Nov 29. Epub 2018 Nov 29.

Universidad Autónoma del Estado de México, Centro de Investigación en Ciencias Médicas, Estado de México, Jesús Carranza No. 205, Colonia Universidad, Toluca de Lerdo, Estado de México, C.P. 50130, Mexico.

Background: The prevalence of food allergy is on the rise on a global scale.

Objective: To determine the prevalence of food hypersensitivity (FHS) and probable food allergy (PFA), as well as the foods and factors associated with these occurrences.

Methods: A cross-sectional study was carried out among 1992 adolescents (aged 15-18 years). Read More

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November 2018

Anti-microbial Resistance In Atopic Dermatitis: Need for an Urgent Rethink.

Ann Allergy Asthma Immunol 2018 Nov 29. Epub 2018 Nov 29.

National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin, Dublin 12, Ireland; Clinical Medicine, Trinity College Dublin, Dublin, Ireland; Paediatric Dermatology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland. Electronic address:

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November 2018

Activation of aryl hydrocarbon receptor negatively regulates thymic stromal lymphopoietin gene expression via PKCδ-p300- NF-κB pathway in keratinocytes under inflammatory conditions.

J Invest Dermatol 2018 Nov 29. Epub 2018 Nov 29.

Department of Life Science, Sogang University, Seoul 04107, Korea. Electronic address:

Epithelial-derived TSLP (thymic stromal lymphopoietin) plays an important role in pathogenesis in several types of dermatitis. Recently, the anti-inflammatory effects of AhR (aryl hydrocarbon receptor) have been reported in inflamed skin. In this study, keratinocytes were stimulated with TNFα or flagellin in combination with AhR ligands or antagonist. Read More

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November 2018

A canine keratinocyte cell line expresses antimicrobial peptide and cytokine genes upon stimulation with bacteria, microbial ligands and recombinant cytokines.

Vet Immunol Immunopathol 2018 Dec 13;206:35-40. Epub 2018 Nov 13.

Department of Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CL, The Netherlands; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, 0110, South Africa. Electronic address:

Keratinocytes (KC) are the main cellular components of the stratum corneum that constitutes a solid physical skin barrier representing the first line of defense against pathogens. Moreover, KC are potent producers of inflammatory mediators and antimicrobial peptides (AMP) when activated through their pattern recognition receptors. In atopic dermatitis (AD) the protective skin barrier may be compromised due to barrier disruption, secondary infection and accelerated secretion of inflammatory cytokines which may also affect AMP expression in the skin. Read More

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December 2018

Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?

Maturitas 2019 Jan 12;119:25-38. Epub 2018 Nov 12.

Institute for Health and Sport, Victoria University, Melbourne, Australia. Electronic address:

As a person ages, physiological, immunological and gut microbiome changes collectively result in an array of chronic conditions. According to the 'hygiene hypothesis' the increasing prevalence of immune-mediated disorders may be related to intestinal dysbiosis, leading to immune dysfunction and associated conditions such as eczema, asthma, allergies and autoimmune diseases. Beneficial probiotic bacteria can be utilized by increasing their abundance within the gastrointestinal lumen, which in turn will modulate immune cells, such as, T helper (Th)-1, Th2, Th17, regulatory T (Treg) cells and B cells, which have direct relevance to human health and the pathogenesis of immune disorders. Read More

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January 2019

Controversies in Allergy: Food Testing and Dietary Avoidance in Atopic Dermatitis.

J Allergy Clin Immunol Pract 2018 Nov 27. Epub 2018 Nov 27.

Division of Allergy, Immunology and Rheumatology, University of Wisconsin-Madison, Madison, Wis. Electronic address:

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November 2018

Impact of soymilk consumption on 2,4-dinitrofluorobenzene-induced contact hypersensitivity and gut microbiota in mice.

Int J Food Sci Nutr 2018 Dec 2:1-6. Epub 2018 Dec 2.

d Fuji Oil Holdings Inc , Research Institute for Creating Future , Izumisano , Osaka , Japan.

Soymilk is rich in phytochemicals such as soy isoflavones (SIs) and soyasaponins (SSs). Dietary SIs and SSs display inhibitory effects on contact hypersensitivity (CHS), which was reported in a mouse model for allergic contact dermatitis (ACD); however, the beneficial effects of soymilk consumption on CHS remain unknown. Here, we studied the effects of drinking soymilk on CHS and gut microbiota. Read More

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December 2018

Oral small molecules for the treatment of atopic dermatitis: a systematic review.

J Dermatolog Treat 2018 Dec 2:1-8. Epub 2018 Dec 2.

a Department of Dermatology , University of California, Irvine , Irvine , CA , USA.

Introduction: Atopic dermatitis (AD) is a chronic, inflammatory skin disease. Conventional treatments include topical emollients, corticosteroids, calcineurin inhibitors, phototherapy, and systemic immunomodulatory agents, however, these medications have limitations in the treatment of moderate to severe AD. Current literature demonstrates that oral small molecules may be an effective modality to treat AD. Read More

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December 2018

The Therapeutic Potential of Cannabinoids in Dermatology

Skin Therapy Lett 2018 11;23(6):1-5

Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC, USA

Cannabinoids have demonstrated utility in the management of cancer, obesity, and neurologic disease. More recently, their immunosuppressive and anti-inflammatory properties have been identified for the treatment of several dermatologic conditions. This review thus assesses the therapeutic potential of phytocannabinoids, endoocannabinoids, and chemically synthetic cannabinoids in the management of cutaneous disease. Read More

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November 2018
2 Reads

Associations Between Immune Phenotype and Inflammation in Murine Models of Irritant Contact Dermatitis.

Toxicol Sci 2018 Dec 4. Epub 2018 Dec 4.

Pharmaceutical Sciences Department, University of Oklahoma Health Science Center, 110 N. Stonewall, Oklahoma City, OK.

Irritant contact dermatitis (ICD), the most common occupational cutaneous illness, is an acute inflammatory response caused by topical irritant exposure. Multiple factors are associated with the manifestation and severity of ICD and contribute to the lack of effective prophylactic and treatment strategies. To determine the pathomechanism of ICD caused by the irritants, benzalkonium chloride (BKC) and JP-8 jet fuel, two mouse strains, C57BL/6 and Balb/c, were assessed due to their differential immune predispositions. Read More

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December 2018
2 Reads

Erratum: Incontinence-associated dermatitis: a cohort study in critically ill patients.

Authors:

Rev Gaucha Enferm 2018 Dec 3;39:e2018e03. Epub 2018 Dec 3.

[This corrects the article doi: 10.1590/1983-1447.2016. Read More

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December 2018
3 Reads

IMPROVEMENT OF THE DERMATENSION METHOD IN THE RECONSTRUCTIVE-RECOVERY SURGERY OF DEFECTS OF SOFT TISSUES OF VARIOUS ETIOLOGY.

Georgian Med News 2018 Oct(283):7-10

Kharkov Medical Academy of Postgraduate Education, Ukraine.

The problem of treating patients with loss of the skin and with a complicated course of the wound process remains topical. The problem is that, despite the relative technical simplicity of the dermatension method, the most significant complication is the decubitus of the stretchable flap, which is associated with a relatively high incidence of acute blood circulatory disturbances in the stretch tissues due to vascular compression with an excessive amount of injected fluid. The aim of the work is to improve the method of dermatension in reconstructive and recovery surgery of soft tissue defects of various genesis by planning and implementing dermatension at all its steps with instrumental control of the process using ultrasound and ICT in a complex. Read More

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October 2018
2 Reads

Cultivating Incontinence-associated Dermatitis Prevention Practices in an Australian Local Health District: A Quasi-experimental Study.

Ostomy Wound Manage 2018 Dec;64(12):16-28

Faculty of Medicine and Health, University of Sydney and Sydney Local Health District, Camperdown, Australia.

Incontinence-associated dermatitis (IAD) is a common, painful, difficult-to-treat skin condition.

Purpose: A 2-part, quasi-experimental, post-test study was conducted to evaluate the impact of prevention initiatives on IAD prevalence and incontinence practices.

Method: In part 1, from May 2017 to November 2017, a quasi-experimental post-test study design was conducted in a health district in Australia. Read More

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December 2018
3 Reads

An update on the cutaneous manifestations of coeliac disease and non-coeliac gluten sensitivity.

Int Rev Immunol 2018 Dec 5:1-10. Epub 2018 Dec 5.

b Institute of Food Sciences, CNR , Avellino , Italy.

Introduction: Coeliac disease is a gluten-induced immune-mediated enteropathy, characterised by the expression of specific genotypes and the production of autoantibodies. The inflammatory process specifically targets the intestinal mucosa, but gastrointestinal and extraintestinal signs and symptoms can also be present. Non-coeliac gluten sensitivity (NCGS) can be diagnosed in individuals who have intestinal and/or extraintestinal symptoms related to the ingestion of gluten, but do not have autoantibodies and do not suffer from lesions in the duodenal mucosa. Read More

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December 2018
1 Read

Filaggrin null mutations are associated with altered circulating Tregs in atopic dermatitis.

J Cell Mol Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.

Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex pathogenesis. Although regulatory T cells (Tregs) have previously been studied in AD, their role remains controversial, likely owing to patient heterogeneity. Thus, we recruited adult AD patients and age-matched healthy controls, and assessed their filaggrin (FLG) genotype, serum IgE level, and eczema area and severity index (EASI). Read More

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December 2018
2 Reads

Notch dysregulation and HS: let's talk about Numb.

Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Via Pansini 5, Napoli, Italy.

We read with great interest the article by J. W. Frew regarding Notch Dysregulation as an Epiphenomenon in Inflammatory Skin Diseases. Read More

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December 2018
2 Reads

Analysis of Epicutaneous Patch Test Results in Patients with Contact Dermatitis.

Med Arch 2018 Oct;72(4):276-279

Department of Dermatovenereology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.

Background: Allergic contact dermatitis (ACD) is a delayed type of hypersensitivity from contact with a specific allergen to which the patients has developed a specific sensitivity. The aim of the study was to evaluate the results of epicutaneous patch testing with standard series of contact allergen in patients suspected to have ACD.

Methods: 355 cases of ACD were included in the study. Read More

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October 2018
3 Reads

Influence of Oral Administration of Lactic Acid Bacteria Metabolites on Skin Barrier Function and Water Content in a Murine Model of Atopic Dermatitis.

Nutrients 2018 Dec 1;10(12). Epub 2018 Dec 1.

Laboratory of Dermatological Physiology, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.

The effects of orally administered lactic acid bacteria metabolites on skin were studied using an atopic dermatitis-like murine model generated by feeding HR-AD to mice. Lactic acid bacteria metabolites were obtained by inoculating and culturing soy milk with 35 strains of 16 species of lactic acid bacteria. The atopic dermatitis-like murine model was generated by feeding HR-AD to HR-1 mice for 40 days. Read More

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December 2018

Complications cutanées de l’obésité.

Rev Prat 2016 Oct;66(8):881-885

Service d'endocrinologie, centre hospitalier de Saint-Denis, Saint-Denis Cedex, France.

Skin complications of obesity. Obesity is associated with a number of skin lesions. It modifies the skin-acting hormones, temperature regulation, skin pressure, immunity and veno-lymphatic vascular systems. Read More

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October 2016

PSORI-CM02 alleviates IMQ-induced mouse dermatitis via differentially regulating pro- and anti-inflammatory cytokines targeting of Th2 specific transcript factor GATA3.

Biomed Pharmacother 2018 Dec 1;110:265-274. Epub 2018 Dec 1.

Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China. Electronic address:

The IL-17-producing CD4+ T cell and γδT cells play critical roles in the pathogenesis of psoriasis (PS). PSORI-CM02 is a representative herbal formula for the treatment for PS in South China. It was confirmed to improve PS without obvious side effects in the clinic. Read More

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December 2018
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