3,297 results match your criteria Dermatitis Herpetiformis


T Cell Response Toward Tissue-and Epidermal-Transglutaminases in Coeliac Disease Patients Developing Dermatitis Herpetiformis.

Front Immunol 2021 20;12:645143. Epub 2021 Apr 20.

Department of Experimental and Clinical Medicine, School of Human Health Sciences, University of Florence, Florence, Italy.

The reason why only few coeliac patients develop the cutaneous manifestation of the disease, named dermatitis herpetiformis (DH), is still unknown. Epidermal transglutaminase (TG3) has been described as the main autoantigen of humoral immunity in DH but the mechanisms leading to this autoimmune response remain obscure. Here we characterized T cells from skin, gut and peripheral blood of DH and coeliac disease (CD) patients, evaluated the impact of the gluten-free diet on circulating T lymphocytes' phenotype and investigated antigen specific T cell response toward epidermal and tissue transglutaminase (TG2). Read More

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Palmar petechiae in a patient with diabetes mellitus.

JAAD Case Rep 2021 May 27;11:109-111. Epub 2021 Mar 27.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

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Educational Case: Dermatitis Herpetiformis.

Acad Pathol 2021 Jan-Dec;8:23742895211006844. Epub 2021 Apr 9.

Laboratories of Pathology, University of Maryland Medical Center, Baltimore, MD, USA.

http://journals.sagepub.com/doi/10. Read More

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Missing Insight Into T and B Cell Responses in Dermatitis Herpetiformis.

Front Immunol 2021 29;12:657280. Epub 2021 Mar 29.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Dermatitis herpetiformis is a cutaneous form of celiac disease manifesting as an itching rash typically on the elbows, knees and buttocks. It is driven by the ingestion of gluten-containing cereals and characterized by granular deposits of immunoglobulin A in the papillary dermis. These antibodies target transglutaminase (TG) 3 and in the majority of patients they are also found in circulation. Read More

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In-Vitro Diagnostics for the Medical Dermatologist: Part 1: Autoimmune Tests.

J Am Acad Dermatol 2021 Apr 11. Epub 2021 Apr 11.

Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. Electronic address:

Despite the expansion of available in-vitro laboratory tests at a rate far exceeding that of dermatological pharmaceuticals, the existing literature is dominated by discussion of the latter. With the advent of numerous new tests, it can be difficult for practicing dermatologists to stay up to date on the available options, methodologies, and recommendations for when to order one test over another. Understanding inherent strengths and weaknesses of these options is necessary to inform appropriate ordering and proper interpretation of results. Read More

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Bullous Pemphigoid Mimicking Cellulitis.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211008585

Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Bullous pemphigoid (BP) is the most prevalent autoimmune blistering skin disease in the Western world affecting mainly the elderly population. The diagnosis is based on clinical assessment along with specific immunopathologic findings on skin biopsy. Risk factors include genetic factors, environmental exposures, and several infections including hepatitis B, hepatitis C, , , and cytomegalovirus. Read More

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Anaemia in Dermatitis Herpetiformis: Prevalence and Associated Factors at Diagnosis and One-year Follow-up.

Acta Derm Venereol 2021 Apr 29;101(4):adv00443. Epub 2021 Apr 29.

Department of Dermatology, Tampere University Hospital, FIN-33521 Tampere, Finland.

Dermatitis herpetiformis is a cutaneous manifestation of coeliac disease. Anaemia is a common finding in patients with untreated coeliac disease, but little is known about the occurrence of anaemia in those with dermatitis herpetiformis. This study investigated the prevalence of anaemia and factors associated with anaemia in 250 patients with dermatitis herpetiformis, at diagnosis and one year after diagnosis. Read More

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A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis.

Acta Dermatovenerol Croat 2020 Dec;28(4):249-250

Hisayoshi Imanishi, MD, PhD, Division of Dermatology, Daito Central Hospital, 2-1-11 Ono, Daito, Osaka 574-0042, Japan;

Dear Editor, Dapsone is a dual-function drug with antimicrobial and antiprotozoal effects and anti-inflammatory features (1). In dermatology, it is a first choice for conditions such as leprosy, IgA pemphigus, dermatitis herpetiformis, and linear IgA bullous dermatosis, or an adjunctive treatment for, e.g. Read More

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December 2020

Development of Dermatitis Herpetiformis in Chronic Plaque Psoriasis.

Case Rep Dermatol 2021 Jan-Apr;13(1):141-147. Epub 2021 Feb 24.

Veracity Clinical Research, Brisbane, Queensland, Australia.

Chronic plaque psoriasis is often associated with autoimmune bullous diseases. Dermatitis herpetiformis (DH) is a rare immunobullous disease that has been linked to celiac disease (CD). To our knowledge, the coexistence of psoriasis and DH is uncommon, and has only been described in anecdotal reports. Read More

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February 2021

EBV-positive Mucocutaneous Ulcer With Small Lymphocytic Infiltration Mimicking Nonspecific Ulceration.

Am J Surg Pathol 2021 05;45(5):694-700

Departments of Diagnostic Pathology.

Epstein-Barr virus (EBV)-associated lymphoproliferative disorder may resemble nonspecific inflammation. We report 3 cases of immunosuppressed adult patients with small lymphocytic EBV ulcers in the skin and oral mucosa, characterized by a lack of atypical lymphocytic infiltration. All 3 cases were diagnosed in routine practice. Read More

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Subepidermal Autoimmune Blistering Dermatoses: Clinical Features and Diagnosis.

J Am Acad Dermatol 2021 Mar 5. Epub 2021 Mar 5.

Department of Dermatology, Mayo, Clinic Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo, Clinic, Rochester, Minnesota.

Subepidermal autoimmune blistering dermatoses are a group of rare skin disorders that are characterized by the disruption of the dermal-epidermal junction through the action of autoantibodies. The third article in this continuing medical education series explores the background, epidemiology, clinical features, and diagnostic criteria of each of the major subepidermal autoimmune blistering dermatoses, including bullous pemphigoid, pemphigoid gestationis, lichen planus pemphigoides, mucous membrane pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis. Read More

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Subepithelial Autoimmune Bullous Dermatoses Disease Activity Assessment and Therapy.

J Am Acad Dermatol 2021 Mar 5. Epub 2021 Mar 5.

Epiphany Dermatology, Dallas, TX. Electronic address:

Subepidermal autoimmune blistering dermatoses are a group of rare skin disorders that are characterized by the disruption of the dermal-epidermal junction through the action of autoantibodies. The fourth article in this continuing medical education series presents the current validated disease activity scoring systems, serologic parameters, treatments, and clinical trials for bullous pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, bullous systemic lupus erythematosus, anti-p200 pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis. Read More

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A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid.

Dermatopathology (Basel) 2021 Feb 23;8(1):33-36. Epub 2021 Feb 23.

Dermatology-IRCCS Policlinico di Sant'Orsola-Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.

Bullous pemphigoid (BP) is an autoimmune bullous disease and is a rare condition in childhood. Acquired tense acral bullae and fixed urticarial annular lesions on the trunk are diagnostic clues of infantile BP. Diagnosis is supported by immunosorbent assay (IgG anti-BP180 and BP230) and direct immunofluorescence (linear deposition of IgG at the dermo-epidermal junction). Read More

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February 2021

Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation.

Authors:
Richard E Kast

Med Sci (Basel) 2021 Feb 16;9(1). Epub 2021 Feb 16.

IIAIGC Study Center, Burlington, VT 05408, USA.

This short note presents previous research data supporting a pilot study of metronomic dapsone during the entire course of glioblastoma treatment. The reviewed data indicate that neutrophils are an integral part of human glioblastoma pathophysiology, contributing to or facilitating glioblastoma growth and treatment resistance. Neutrophils collect within glioblastoma by chemotaxis along several chemokine/cytokine gradients, prominently among which is interleukin-8. Read More

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February 2021

Coeliac disease presenting atypically: A much wider spectrum.

Trop Doct 2021 Feb 11:49475521991348. Epub 2021 Feb 11.

Director Professor, Genetic division, Department of Pediatrics, Maulana Azad Medical College, Lok Nayak Hospital, New Delhi, India.

Atypical coeliac disease in young children is frequently missed when it presents atypically as non-gastrointestinal presentations to different specialties. There was a greater delay (54 months) in establishing the diagnosis in those with atypical coeliac disease (p < 0.001). Read More

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February 2021

Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes.

J Hum Genet 2021 Jan 15. Epub 2021 Jan 15.

Coeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

The phenotype of coeliac disease varies considerably for incompletely understood reasons. We investigated whether established coeliac disease susceptibility variants (SNPs) are individually or cumulatively associated with distinct phenotypes. We also tested whether a polygenic risk score (PRS) based on genome-wide associated (GWA) data could explain the phenotypic variation. Read More

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January 2021

Dermatitis Herpetiformis: An Update on Diagnosis and Management.

Am J Clin Dermatol 2021 May;22(3):329-338

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Dermatitis herpetiformis (DH), presenting with an intense itch and blistering symmetrical rash, typically on the elbows, knees, and buttocks, is a cutaneous manifestation of celiac disease. Though overt gastrointestinal symptoms are rare, three-fourths of patients with DH have villous atrophy in the small bowel, and the rest have celiac-type inflammatory changes. DH affects mostly adults and slightly more males than females. Read More

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Granular Deposits of IgA in the Skin of Coeliac Patients Without Dermatitis Herpetiformis: A Prospective Multicentric Analysis.

Acta Derm Venereol 2021 Feb 2;101(2):adv00382. Epub 2021 Feb 2.

Section of Dermatology, Department of Health Sciences, University of Florence, IT-50125 Florence, Italy.

Granular deposits of IgA represent the specific cutaneous marker of dermatitis herpetiformis. The prevalence of IgA deposits in the skin of patients with coeliac disease without dermatitis herpetiformis remains unknown. In this prospective case-control study, skin biopsies from newly diagnosed coeliac patients without dermatitis herpetiformis were analysed by direct immunofluorescence. Read More

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February 2021

Determinants and Trends of Adherence to a Gluten-Free Diet in Adult Celiac Patients on a Long-Term Follow-Up (2000-2020).

Clin Gastroenterol Hepatol 2020 Dec 15. Epub 2020 Dec 15.

Istituti Clinici Scientifici Maugeri, IRCCS, Gastroenterology Unit of Pavia Institute, University of Pavia, Pavia, Italy.

Background & Aims: Data on factors governing long-term adherence to a gluten-free diet (GFD) in celiac disease (CD) are scarce. We aimed to determine trends and clinical predictors of long-term GFD adherence in adult CD.

Methods: Initial and long-term (>3 years) GFD adherence, clinical characteristics at baseline and follow-up were collected retrospectively from patients with celiac followed-up over 20 years (2000-2020). Read More

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December 2020

T-Cell Response in Dermatitis Herpetiformis: May Epidermal Transglutaminase Play a Role in Predicting Clinical Relapse?

J Invest Dermatol 2020 Dec 8. Epub 2020 Dec 8.

Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.

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December 2020

Grain Intake and Human Health.

Authors:
Fabiana Zingone

Nutrients 2020 Dec 4;12(12). Epub 2020 Dec 4.

Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, 35128 Padua, Italy.

Wheat is one of the most consumed cereal grains worldwide and represents an important part of the human diet [... Read More

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December 2020

Recalcitrant dermatitis herpetiformis treated successfully with sulfasalazine.

Int J Dermatol 2021 Apr 23;60(4):e149-e150. Epub 2020 Nov 23.

Department of Dermatology, St. Vincent's University Hospital, Dublin, Ireland.

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A bullous rash.

Arch Dis Child Educ Pract Ed 2020 Nov 19. Epub 2020 Nov 19.

Pediatric Department, University of Trieste, Trieste, Italy.

A 3-year-old boy presented with a 5-day history of bullous skin lesions localised mainly in the upper and lower limbs and in the genital region (figure 1). Lesions were not pruritic nor painful and showed a central crust. There was no family history of skin disorders or autoimmune diseases. Read More

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November 2020

[PUSTULAR PSORIASIS DURING PREGNANCY: WHEN IS THE RIGHT TIME TO DELIVER?]

Harefuah 2020 Nov;159(11):789-792

Department of Obstetrics and Gynecology, the Edith Wolfson Medical Center, Holon, Israel.

Introduction: General pustular pruritus psoriasis (GPPP), also known by the name impetigo herpetiformis, is a rare type of pustular dermatosis which typically occurs in pregnant women during the 3rd trimester and usually regresses after birth. The disease is characterized by acute abruption of erythematous plaque with a disseminated spread of sterile pustule, and may progress to sepsis and even death. Notably, it also carries obstetric complications and is associated with an increase in neonatal morbidity and stillbirth. Read More

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November 2020

Non infective bullous lesions: a diagnostic challenge in a minimally equipped centre- based solely on microscopic findings.

Afr Health Sci 2020 Jun;20(2):885-890

Pandit Deendayal Upadhyay Medical College.

Vesicobullous lesions of skin may occur in different forms of dermatosis, which include various inflammatory, infective, autoimmune, drug induced as well as genetic conditions. Autoimmune bullous lesions, may be fatal if not treated with appropriate agents. Bearing in mind, the morbidity of these diseases, it is important to establish a firm diagnosis. Read More

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Risk of Skin Disorders in Patients with Celiac Disease: A Population-Based Cohort Study.

J Am Acad Dermatol 2020 Oct 31. Epub 2020 Oct 31.

Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York NY, USA; Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden.

Background And Aims: Although dermatitis herpetiformis is closely associated with celiac disease (CD), data on the relationship between CD and other dermatologic disorders have been mixed. We aimed to quantify the risk of skin disorders in patients after CD diagnosis in a population-based setting.

Methods: Using data from all 28 pathology departments in Sweden 1969-2016, we identified patients with CD. Read More

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October 2020

Free perforation of primary small bowel lymphoma in a patient with celiac sprue and dermatitis herpetiformis.

Ulus Travma Acil Cerrahi Derg 2020 11;26(6):955-959

Department of Surgical Oncology, Cukurova University, Faculty of Medicine, Adana, Turkey.

Small bowel lymphomas are rare and constitute approximately 1% of the malignant gastrointestinal tumors. However, the risk of malignant disease in adult celiac disease is about 8-10%, and non-Hodgkin lymphoma is the most common. In the literature, cases with celiac disease and small bowel lymphoma have been reported, but the emphasis on emergency surgery is extremely rare. Read More

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November 2020

Autoantibodies Against the Immunodominant Bullous Pemphigoid Epitopes Are Rare in Patients With Dermatitis Herpetiformis and Coeliac Disease.

Front Immunol 2020 25;11:575805. Epub 2020 Sep 25.

PEDEGO Research Unit, Department of Dermatology, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.

Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease (CD). Patients with DH have an elevated risk of development of another autoimmune blistering skin disease, bullous pemphigoid (BP). In this study we investigated whether patients with DH and CD (mean age for both 49 years) have circulating autoantibodies against BP180, the major BP autoantigen. Read More

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September 2020