3,198 results match your criteria Dermatitis Herpetiformis


Gluten challenge induces skin and small bowel relapse in long-term gluten-free diet-treated dermatitis herpetiformis.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Tampere University Hospital, Tampere, Finland; Celiac Disease Research Center, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland. Electronic address:

Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease causing an itchy, blistering rash. Skin IgA deposits are pathognomonic for DH, and the treatment of choice is a life-long gluten-free diet (GFD). Preliminary evidence suggests that there are DH patients who redevelop gluten tolerance after adherence to a GFD treatment. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1150DOI Listing
April 2019
1 Read

Metabolic, pharmacokinetic, and toxicological issues surrounding dapsone.

Expert Opin Drug Metab Toxicol 2019 Apr 4:1-13. Epub 2019 Apr 4.

a Dermatological Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.

Introduction: In their 70-year history, dapsone and other sulfones have been used as both antibacterial and anti-inflammatory agents. Dapsone has been the main active principle in the multidrug regimen recommended by the World Health Organization for the treatment of leprosy. In addition, dapsone has been successfully used to treat a wide range of dermatological and systemic disorders, mostly characterized by neutrophilic and eosinophilic accumulation and infiltration. Read More

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http://dx.doi.org/10.1080/17425255.2019.1600670DOI Listing
April 2019
2 Reads

[Autoimmune blistering dermatoses in children].

Hautarzt 2019 Apr;70(4):277-282

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

Autoimmune blistering skin disorders represent a rare group of autoantibody-induced dermatoses against desmosomal and hemidesmosomal molecules. The common age of onset for pemphigus and pemphigoid, as well as dermatitis herpetiformis, encompasses the adult age, but all these disorders can be observed neonatally and/or during childhood. If the disease occurs postpartum or neonatally, physicians should consider transplacental transmission of pathogenic maternal immunoglobulin G (IgG)-autoantibodies, and both mother and child should be included in the diagnostic work up. Read More

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http://dx.doi.org/10.1007/s00105-019-4379-7DOI Listing
April 2019
4 Reads

Dermatitis herpetiformis arising within vitiligo in a patient with autoimmune polyendocrine syndrome type 3.

Int J Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Allergology and Venereology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/ijd.14446DOI Listing

Clinical, pathologic, and immunologic features of pemphigus herpetiformis: a literature review and proposed diagnostic criteria.

Int J Dermatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Dermatology, Mayo Clinic, Jacksonville, FL, USA.

Pemphigus herpetiformis (PH), a rare type of pemphigus, is characterized by immunologic findings consistent with pemphigus but with a unique clinical and pathologic presentation. PH was first described as resembling dermatitis herpetiformis clinically, but because of its variable presentation, it can also resemble linear immunoglobulin A bullous dermatosis and bullous pemphigoid. We reviewed reported cases to analyze the most frequent clinical, pathologic, and immunologic characteristics and to propose corresponding diagnostic criteria. Read More

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http://dx.doi.org/10.1111/ijd.14395DOI Listing

DNA damage in human skin fibroblasts from patients with dermatitis herpetiformis

Eur J Dermatol 2019 03 11. Epub 2019 Mar 11.

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano,, Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico,, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.

Dermatitis herpetiformis (DH) and celiac disease (CD) are considered to be autoimmune diseases that share a specific trigger (gluten) and a common genetic background (HLA-DQ2/DQ8). However, the pathogenesis of DH is not yet fully understood and no data are available regarding a possible role of fibroblasts in this disease. The aim of this study was to assess baseline DNA damage in fibroblasts in DH-diagnosed patients vs. Read More

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http://dx.doi.org/10.1684/ejd.2019.3528DOI Listing
March 2019
7 Reads

[Linear IgA bullous dermatosis].

Hautarzt 2019 Apr;70(4):254-259

Klinik für Dermatologie, Venerologie und Dermatoonkologie, Fakultät für Medizin, Semmelweis Universität, Budapest, Ungarn.

Linear IgA bullous dermatosis is a rare autoimmune blistering disease that occurs in both children and adults. Strings of pearls, crowns of jewels, rosettes and urticarial plaques can occur on the whole integument with emphasis on the face (particularly perioral area) and genitalia. Pruritus is common and may be severe. Read More

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http://dx.doi.org/10.1007/s00105-019-4377-9DOI Listing

[Dermatitis herpetiformis].

Hautarzt 2019 Apr;70(4):260-264

Klinik für Dermatologie, Venerologie und Dermatoonkologie, Fakultät für Medizin, Semmelweis Universität, Budapest, Ungarn.

Dermatitis herpetiformis (DH) is a genetically determined, gluten sensitive autoimmune bullous dermatosis related to celiac disease in which granular, insoluble aggregates in the papillary dermis of epidermal transglutaminase (TG3), immunoglobulin A (IgA), and fibrinogen are present. Detection of the dermal IgA-TG3 immune complex is the gold standard of diagnosis. DH develops in a subpopulation of patients with gluten sensitive enteropathy, characterized by itching, erythematous, excoriated papules showing characteristic distribution over the knees, elbows and buttocks; vesicles are rarely seen. Read More

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http://dx.doi.org/10.1007/s00105-019-4378-8DOI Listing
April 2019
2 Reads

Prevalence of gluten-related disorders in Asia-Pacific region: a systematic review.

J Gastrointestin Liver Dis 2019 Mar;28(1):95-105

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Aims: The epidemiology of gluten-related disorders (GRDs) is still an open field to be explored. We conducted this systematic review based on the current epidemiology knowledge of GRDs, focusing on the changing prevalence of GRDs reported in the Asia-Pacific region.

Methods: We searched Medline, PubMed, Scopus, Web of Science and Cochrane database with the following MeSH terms and keywords: celiac disease (CD), wheat allergy (WA), non-celiac gluten sensitivity (NCGS), dermatitis herpetiformis (DH) and gluten ataxia (GA) and the prevalence studies published from January 1991 to January 2018. Read More

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http://dx.doi.org/10.15403/jgld.2014.1121.281.sysDOI Listing
March 2019
1 Read

A Case of Dermatitis Herpetiformis With Fibrillar Immunoglobulin A Deposition: A Rare Pattern Not to Be Missed.

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology and Laboratory Medicine, Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Dermatitis herpetiformis is a rare, chronic autoimmune disorder characterized by intense pruritic papules and vesicles, which can be associated with celiac disease and other autoimmune disorders. Its histologic characteristic is the accumulation of neutrophils within the papillary dermis with granular deposition of immunoglobulin A (IgA) observed under direct immunofluorescence. Herein, we report a 58-year-old woman who presented with a vesicular rash on the buttocks. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001380DOI Listing
February 2019
2 Reads

IMMUNE MEDIATED DISEASES IN PATIENTS WITH CELIAC DISEASE AND THEIR RELATIVES: A COMPARATIVE STUDY OF AGE AND SEX.

Arq Gastroenterol 2018 Oct-Dec;55(4):346-351

Universidade Federal do Paraná, Hospital de Clínicas, Curitiba, PR, Brasil.

Background: Up to 15% of other immune-mediated diseases (IMDs) can occur in patients with CD throughout their lives and are associated with multiple factors, including sex and sex hormone levels. Moreover, sex is associated with differences in clinical presentation, onset, progression, and outcomes of disorders.

Objective: To investigate the prevalence of IMDs at diagnosis in patients with celiac disease (CD) and their first-degree relatives and to compare the findings between female and male patients of different age. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-77DOI Listing
March 2019
1 Read

HLA-DQ2 homozygosis increases tTGA levels at diagnosis but does not influence the clinical phenotype of coeliac disease: A multicentre study.

Int J Immunogenet 2019 Apr 19;46(2):74-81. Epub 2019 Feb 19.

Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.

Background And Purpose: Magnitude of gluten-specific T-cell responses in coeliac disease (CD) might be dependent on HLA-DQ2 gene dose. We aimed to investigate the effects of HLA-DQB1*02 allele dose on clinical outcomes.

Methods: We reviewed the charts of all coeliac patients attending to three Hungarian university clinics after 1997 and included those patients, who (a) were diagnosed with CD, (b) underwent high-resolution HLA typing and (c) were ≥18 years at the time of data collection. Read More

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http://dx.doi.org/10.1111/iji.12415DOI Listing
April 2019
5 Reads

Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease-Celiac Trait.

Nutrients 2019 Feb 1;11(2). Epub 2019 Feb 1.

Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33520 Tampere, Finland.

Celiac disease patients may suffer from a number of extra-intestinal diseases related to long-term gluten ingestion. The diagnosis of celiac disease is based on the presence of a manifest small intestinal mucosal lesion. Individuals with a normal biopsy but an increased risk of developing celiac disease are referred to as potential celiac disease patients. Read More

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http://dx.doi.org/10.3390/nu11020320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412544PMC
February 2019
2 Reads

Dermatitis Herpetiformis and Celiac Disease Increase the Risk of Bullous Pemphigoid.

J Invest Dermatol 2019 Mar 26;139(3):600-604. Epub 2018 Oct 26.

PEDEGO Research Unit, University of Oulu, Oulu, Finland; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland. Electronic address:

Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are autoimmune bullous skin diseases. DH has been described to evolve into BP and the two diseases can have overlapping clinical appearances and diagnostic findings, but the association between DH and BP has not previously been studied in a large population. To evaluate DH and celiac disease as risk factors for BP, we conducted a retrospective case-control study of patients with BP and matched controls with basal cell carcinoma diagnosed in Finland between 1997 and 2013. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183270
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http://dx.doi.org/10.1016/j.jid.2018.10.010DOI Listing
March 2019
11 Reads

Transglutaminase diseases: from biochemistry to the bedside.

FASEB J 2019 01;33(1):3-12

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.

In humans, 9 members of the transglutaminase (TG) family have been identified, of which 8 [factor XIII (FXIII)A and TG1-TG7] catalyze post-translational protein-modifying reactions, and 1 does not (protein 4.2). The TG enzymatic activities considered in our discussion of human disease include deamidation of glutamine (Gln) residues, amine incorporation into Gln residues, and protein crosslinking. Read More

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http://dx.doi.org/10.1096/fj.201801544RDOI Listing
January 2019
4 Reads

An update on the cutaneous manifestations of coeliac disease and non-coeliac gluten sensitivity.

Int Rev Immunol 2018 5;37(6):291-300. Epub 2018 Dec 5.

b Institute of Food Sciences, CNR , Avellino , Italy.

Introduction: Coeliac disease is a gluten-induced immune-mediated enteropathy, characterised by the expression of specific genotypes and the production of autoantibodies. The inflammatory process specifically targets the intestinal mucosa, but gastrointestinal and extraintestinal signs and symptoms can also be present. Non-coeliac gluten sensitivity (NCGS) can be diagnosed in individuals who have intestinal and/or extraintestinal symptoms related to the ingestion of gluten, but do not have autoantibodies and do not suffer from lesions in the duodenal mucosa. Read More

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https://www.tandfonline.com/doi/full/10.1080/08830185.2018.1
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http://dx.doi.org/10.1080/08830185.2018.1533008DOI Listing
December 2018
31 Reads

Diagnosis of Autoimmune Blistering Diseases.

Front Med (Lausanne) 2018 2;5:296. Epub 2018 Nov 2.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Autoimmune skin blistering diseases (AIBD) are characterized by autoantibodies that are directed against structural proteins in the skin and adjacent mucous membranes. Some clinical signs are typical for a specific AIBD, however, correct diagnosis requires the detection of tissue-bound or circulating autoantibodies. The gold standard for diagnosis of AIBD is the detection of autoantibodies or complement component 3 by direct immunofluorescence (DIF) microscopy of a perilesional biopsy. Read More

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http://dx.doi.org/10.3389/fmed.2018.00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224342PMC
November 2018
22 Reads

Bullous autoimmune dermatoses.

J Dtsch Dermatol Ges 2018 Nov;16(11):1339-1358

Department of Dermatology and Allergology, Marburg University Medical Center, Marburg, Germany.

Pathophysiologically, bullous autoimmune dermatoses are caused by autoantibodies directed against adhesion molecules or structural proteins of the skin and mucous membranes, clinically resulting in blister formation. Depending on the respective target proteins of the autoimmune response and their location in the skin, a distinction is made between intraepidermal (pemphigus disorders), junctional (pemphigoid disorders), and subepidermal (epidermolysis bullosa acquisita, dermatitis herpetiformis) autoimmune blistering diseases. The most common bullous autoimmune dermatosis, bullous pemphigoid is characterized by marked clinical variability and intense pruritus. Read More

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http://dx.doi.org/10.1111/ddg.13688DOI Listing
November 2018
24 Reads

Two Cases of Dermatitis Herpetiformis Successfully Treated with Tetracycline and Niacinamide.

Acta Dermatovenerol Croat 2018 Oct;26(3):273-275

Baoqi Yang, MD, Department of Dermatology Shandong Provincial Institute of Dermatology and Venereology Shandong Academy of Medical Sciences 27397 Jingshi Road, Jinan, Shandong, 250022, China;

Dear Editor, Dermatitis herpetiformis (DH) is a chronic, polymorphic, pruritic autoimmune blistering skin disease characterized by subepidermal blisters, neutrophilic microabscesses, and granular IgA deposition within the dermal papillae. DH is classified as a cutaneous manifestation of coeliac disease, a type of gluten-sensitive enteropathy (1). The treatment of DH includes dapsone and a gluten-free diet (GFD). Read More

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October 2018
24 Reads

Celiac Disease in the Pediatric Population.

J Pediatr Health Care 2018 Nov - Dec;32(6):627-631

Celiac disease is an autoimmune disorder in which the lining of the gastrointestinal tract is damaged by an immune-mediated response to gluten proteins (Allen, 2015). It is a polygenetic disease that only appears in genetically susceptible individuals (Newton & Singer, 2012). It is a worldwide concern, with North America having a high prevalence rate (Liu et al. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915245173064
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http://dx.doi.org/10.1016/j.pedhc.2018.04.023DOI Listing
December 2017
36 Reads

Dermatitis herpetiformis in an African woman.

Pan Afr Med J 2018 12;30:119. Epub 2018 Jun 12.

Dermatology and Venereology Clinic, Adult Hospital of University Teaching Hospital, Lusaka, Zambia.

Dermatitis herpetiformis (DH) is an autoimmune blistering disease of the skin. It is a result of hypersensitivity to dietary gluten. Diagnosis of DH can be challenging in a low prevalence, resource-limited population. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.119.14012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195247PMC
November 2018
5 Reads

Risk Factors Associated with the Occurrence of Autoimmune Diseases in Adult Coeliac Patients.

Gastroenterol Res Pract 2018 12;2018:3049286. Epub 2018 Sep 12.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy.

Objectives: Autoimmune diseases (AD) may be associated with coeliac disease (CD), but specific risk factors have been poorly investigated. The aim of this study was to assess the spectrum of AD and its specific risk factors associated in a series of adult coeliac patients.

Materials And Methods: We performed a single-center case-control study including adult newly diagnosed CD patients. Read More

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http://dx.doi.org/10.1155/2018/3049286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157138PMC
September 2018
3 Reads

Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats.

Clin Exp Emerg Med 2018 Sep 30;5(3):192-198. Epub 2018 Sep 30.

Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.

Objective: Dapsone (diaminodiphenyl sulfone, DDS) is currently used to treat leprosy, malaria, dermatitis herpetiformis, and other diseases. It is also used to treat pneumocystis pneumonia and Toxoplasma gondii infection in HIV-positive patients. The most common adverse effect of DDS is methemoglobinemia from oxidative stress. Read More

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http://dx.doi.org/10.15441/ceem.17.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166037PMC
September 2018
13 Reads

Coeliac disease and dermatitis herpetiformis - Authors' reply.

Lancet 2018 09;392(10151):917

Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)31894-4DOI Listing
September 2018
11 Reads

Coeliac disease and dermatitis herpetiformis.

Lancet 2018 09;392(10151):916

Department of Internal Medicine, Tenon Hospital (AP-HP), Paris 75020, France. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)31503-4DOI Listing
September 2018
3 Reads

Coeliac disease and dermatitis herpetiformis.

Lancet 2018 09;392(10151):916-917

Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1016/S0140-6736(18)31486-7DOI Listing
September 2018
4 Reads

Non-infectious diffuse vesiculobullous rash in a pancreas and renal transplant recipient.

Transpl Infect Dis 2018 Dec 21;20(6):e12990. Epub 2018 Sep 21.

Department of Medicine, Division of Infectious Diseases & Global Medicine, College of Medicine, University of Florida, Gainesville, Florida.

Solid organ transplant patients are well established to be at risk of herpes simplex virus and varicella zoster virus infection and reactivation. We present a case of a 41-year-old woman with a history of pancreas and renal transplant who presented with what appeared to be disseminated herpes simplex virus or varicella zoster virus induced rash, but who was ultimately diagnosed and treated as linear IgA bullous dermatosis. This case alerts physicians to other non-infectious dermatoses as a cause of vesiculobullous rash in solid organ transplant patients. Read More

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http://dx.doi.org/10.1111/tid.12990DOI Listing
December 2018
6 Reads

Diagnostik blasenbildender Autoimmundermatosen.

J Dtsch Dermatol Ges 2018 Sep;16(9):1077-1092

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck.

Blasenbildende Autoimmundermatosen (BAIDs) sind eine heterogene Gruppe seltener Erkrankungen, die klinisch durch Erosionen und/oder Blasen an Haut und Schleimhäuten charakterisiert sind. BAIDs können in zwei Gruppen eingeteilt werden: Pemphigus-Erkrankungen, die durch intraepidermale Blasenbildung und Autoantikörper gegen desmosomale Proteine wie Desmoglein (Dsg) 1, Dsg3 und Mitglieder der Plakin-Familie charakterisiert sind, sowie subepidermale BAIDs, die Pemphigoid-Erkrankungen und die Dermatitis herpetiformis umfassen. Bei der Dermatitis herpetiformis greifen die Autoantikörper die Transglutaminasen 2 und 3 an, während sie bei Pemphigoid-Erkrankungen gegen Strukturproteine der dermoepidermalen Junktionszone gerichtet sind. Read More

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http://dx.doi.org/10.1111/ddg.13637_gDOI Listing
September 2018
1 Read

Diagnosis of autoimmune bullous diseases.

J Dtsch Dermatol Ges 2018 Sep;16(9):1077-1091

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Autoimmune bullous disorders (AIBDs) are a heterogeneous group of rare diseases clinically characterized by erosions and/or blisters on the skin and mucous membranes. AIBDs can be categorized into two groups: pemphigus diseases, characterized by intraepidermal blistering and autoantibodies against desmosomal proteins such as desmoglein (Dsg) 1, Dsg3, members of the plakin family, and subepidermal AIBDs, comprised of pemphigoid diseases and dermatitis herpetiformis. Autoantibodies in dermatitis herpetiformis target transglutaminases 2 and 3, while in pemphigoid disease, autoantibodies are directed against structural proteins of the dermal-epidermal junction. Read More

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http://dx.doi.org/10.1111/ddg.13637DOI Listing
September 2018
2 Reads

Facial Involvement in Dermatitis Herpetiformis: A Case Report and Review of the Literature.

J Cutan Med Surg 2019 Jan/Feb;23(1):35-37. Epub 2018 Aug 13.

1 Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada.

Dermatitis herpetiformis is a cutaneous manifestation of celiac disease that classically presents as a symmetric pruritic vesicular eruption on extensor surfaces. Typical locations include elbows, knees, and buttocks. Facial involvement has been reported rarely. Read More

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http://dx.doi.org/10.1177/1203475418795818DOI Listing
August 2018
8 Reads

Coeliac disease.

Paediatr Int Child Health 2019 02 13;39(1):23-31. Epub 2018 Aug 13.

a Division of Gastroenterology and Hepatology , Beth Israel Deaconess Medical Center , Boston , Massachusetts , USA.

Coeliac disease (CD) develops in genetically susceptible individuals who, in response to unclear environmental triggers, develop an immune response triggered by gluten ingestion. It is now recognised as a global disease affecting about 0.7% of the world's population. Read More

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http://dx.doi.org/10.1080/20469047.2018.1504431DOI Listing
February 2019
10 Reads

The Value of Etiological Tests and Skin Biopsy in the Management of Prurigo Simplex Subacuta.

Acta Dermatovenerol Croat 2017 Dec;25(4):276-278

Suhan Günaştı Topal, MD, University of Çukurova, Department of Dermatology 01330 Balcalı, Sarıçam, Adana, Turkey;

It has been emphasized that prurigo simplex subacuta may be associated with various disorders and may be clinically confused with dermatitis herpetiformis. Aim of the study was to evaluate the value of our set of tests for finding possible associations and for the aforementioned differential diagnosis. Rates of implementations and abnormal results in our set of tests, including skin prick test, skin biopsy, complete blood count, blood chemistry panel, and psychiatric evaluation were analyzed retrospectively between the years of 2010 and 2015 in 130 patients clinically diagnosed with prurigo simplex subacuta. Read More

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December 2017
4 Reads

Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus?

Int J Dermatol 2018 Sep 16;57(9):1094-1101. Epub 2018 Jul 16.

Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Background: Pemphigus herpetiformis (PH) is a rare subtype of pemphigus combining clinical features of dermatitis herpetiformis and the immunopathologic characteristics of pemphigus. We aimed to analyze the epidemiological, clinical, and immunological presentation and management of the disease in a cohort of south Tunisian patients with a long-term follow-up.

Methods: We included all patients with confirmed PH followed from January 1987 to December 2015 in the dermatology department. Read More

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http://dx.doi.org/10.1111/ijd.14139DOI Listing
September 2018
12 Reads

Granular IgA Deposits in the Skin of Patients with Coeliac Disease: Is it Always Dermatitis Herpetiformis?

Acta Derm Venereol 2019 01;99(1):78-83

Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, IT-50129 Florence, Italy.

Coeliac disease is an immune-mediated enteropathy driven by gluten, which can be associated with dermatitis herpetiformis. The presence of granular IgA deposits, detected by direct immunofluorescence, is the hallmark of dermatitis herpetiformis; nevertheless, IgA deposits have also been demonstrated in healthy skin of patients with coeliac disease. The main objective of this study was to investigate whether IgA deposits could be found in the skin of patients with coeliac disease who have non-dermatitis herpetiformis inflammatory skin diseases. Read More

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http://dx.doi.org/10.2340/00015555-3001DOI Listing
January 2019
11 Reads

Thyroid diseases and skin autoimmunity.

Rev Endocr Metab Disord 2018 12;19(4):311-323

Department of Surgical Sciences, "Sapienza" University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy.

The skin is the largest organ of the body, at the boundary with the outside environment. Primarily, it provides a physical and chemical barrier against external insults, but it can act also as immune organ because it contains a whole host of immune-competent cells of both the innate and the adaptive immune systems, which cooperate in eliminating invading pathogens following tissue injury. On the other hand, improper skin immune responses lead to autoimmune skin diseases (AISD), such as pemphigus, bullous pemphigoid, vitiligo, and alopecia. Read More

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http://dx.doi.org/10.1007/s11154-018-9450-7DOI Listing
December 2018
7 Reads

Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction.

Sci Rep 2018 Jun 26;8(1):9690. Epub 2018 Jun 26.

International Collaboration On Repair Discoveries (ICORD) Research Centre, Vancouver, BC, V5Z 1M9, Canada.

In healthy skin, epidermis and dermis are anchored together at the dermal-epidermal junction (DEJ), a specialized basement membrane pivotal for skin integrity and function. However, increased inflammation in the DEJ is associated with the disruption and separation of this junction and sub-epidermal blistering. Granzyme B (GzmB) is a serine protease secreted by immune cells. Read More

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http://dx.doi.org/10.1038/s41598-018-28070-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018769PMC
June 2018
29 Reads

Low hba1c; Is It Dapsone?

J Ayub Med Coll Abbottabad 2018 Apr-Jun;30(2):301-303

Pennine Acute Hospitals NHS Trust, United Kingdom.

A 51-year-old male was referred to the diabetes clinic by the GP with low HbA1c (13 mmol/mol). His complaints were dizziness and intermittent palpitations for the last two years. No precipitating cause could be identified. Read More

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October 2018
3 Reads

Cutaneous and Mucosal Manifestations Associated with Celiac Disease.

Nutrients 2018 Jun 21;10(7). Epub 2018 Jun 21.

Dermatology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain.

Celiac disease (CD) is an immune-mediated, gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, with dermatitis herpetiformis (DH) being the best characterized. Read More

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http://dx.doi.org/10.3390/nu10070800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073559PMC
June 2018
4 Reads

Adult linear IgA bullous dermatosis: report of three cases.

An Bras Dermatol 2018 Jun;93(3):435-437

Department of Dermatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Linear immunoglobulin A bullous dermatosis is a rare autoimmune disease that usually has an excellent prognosis in childhood; however, its control is more difficult in adults. It presents heterogeneous clinical manifestations and is frequently confused with other bullous diseases such as bullous pemphigoid and Duhring's dermatitis herpetiformis. Dermatologists' awareness of this disease contributes to early diagnosis and appropriate treatment. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20187304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001096PMC
June 2018
22 Reads

Why now? Delayed drug-induced pancreatitis due to dapsone for dermatitis herpetiformis.

J Community Hosp Intern Med Perspect 2018 12;8(3):156-157. Epub 2018 Jun 12.

Internal Medicine Department, Rochester General Hospital, Rochester, New York, USA.

Drug-induced pancreatitis can be caused by a wide array of medications. In fact, the diagnosis is likely commonly missed due to the difficulty in diagnosing one agent as the sole cause. We present a case of dapsone-induced pancreatitis in a 75-year-old male with history of celiac disease. Read More

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http://dx.doi.org/10.1080/20009666.2018.1475189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998278PMC
June 2018
3 Reads

Prognosis of Dermatitis Herpetiformis Patients with and without Villous Atrophy at Diagnosis.

Nutrients 2018 May 19;10(5). Epub 2018 May 19.

Department of Dermatology, Tampere University Hospital, 33521 Tampere, Finland.

Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease. At diagnosis, the majority of patients have villous atrophy in the small bowel mucosa. The objective of this study was to investigate whether the presence or absence of villous atrophy at diagnosis affects the long-term prognosis of DH. Read More

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http://dx.doi.org/10.3390/nu10050641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986520PMC
May 2018
5 Reads

Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease.

Nutrients 2018 May 12;10(5). Epub 2018 May 12.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, 33521 Tampere, Finland.

Dermatitis herpetiformis (DH) is a common extraintestinal manifestation of coeliac disease presenting with itchy papules and vesicles on the elbows, knees, and buttocks. Overt gastrointestinal symptoms are rare. Diagnosis of DH is easily confirmed by immunofluorescence biopsy showing pathognomonic granular immunoglobulin A (IgA) deposits in the papillary dermis. Read More

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http://dx.doi.org/10.3390/nu10050602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986482PMC
May 2018
4 Reads

A retrospective study of dermatitis herpetiformis from an immunobullous disease clinic in north India.

Int J Dermatol 2018 Aug 11;57(8):959-964. Epub 2018 May 11.

Department of Histopathology, PGIMER, Chandigarh, India.

Background: Indian data on dermatitis herpetiformis (DH) is not available. The aim of this study was to investigate the demographic and clinicopathological characteristics of patients with DH and to study its association with other autoimmune diseases.

Methods: All data were collected from case record forms of patients registered in immunobullous disease clinic of our institute. Read More

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http://doi.wiley.com/10.1111/ijd.14029
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http://dx.doi.org/10.1111/ijd.14029DOI Listing
August 2018
13 Reads

Histologic characterization of cellular infiltration in autoimmune subepidermal bullous diseases in a tertiary hospital in Saudi Arabia.

Clin Cosmet Investig Dermatol 2018 24;11:187-194. Epub 2018 Apr 24.

Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Autoimmune subepidermal bullous dermatoses have similar clinical features to those of a spectrum of immune reactants at the dermoepidermal junction (DEJ). It is difficult to obtain a precise diagnosis without an immunofluorescence assay because of their similar clinical presentations. The aim of this study was to describe the cellular cutaneous infiltration among autoimmune subepidermal bullous dermatoses. Read More

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https://www.dovepress.com/histologic-characterization-of-cel
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http://dx.doi.org/10.2147/CCID.S158388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927141PMC
April 2018
5 Reads

Novel association of a papuloerythroderma of Ofuji phenotype with dermatitis herpetiformis.

Int J Dermatol 2018 07 17;57(7):856-857. Epub 2018 Apr 17.

Department of Dermatology, Changi General Hospital, Singapore.

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http://doi.wiley.com/10.1111/ijd.13978
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http://dx.doi.org/10.1111/ijd.13978DOI Listing
July 2018
17 Reads

Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm.

World J Gastroenterol 2018 Apr;24(14):1521-1530

Section of Gastroenterology, Department of Emergency and Organ Transplantation, University "Aldo Moro" of Bari, Bari 70124, Italy.

Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most cases they are characterized by vague symptoms such as 'foggy mind', headache, fatigue, joint and muscle pain, leg or arm numbness even if more specific complaints have been described. Read More

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http://dx.doi.org/10.3748/wjg.v24.i14.1521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897856PMC
April 2018
2 Reads

Natural history and clinical detection of undiagnosed coeliac disease in a North American community.

Aliment Pharmacol Ther 2018 May 25;47(10):1358-1366. Epub 2018 Mar 25.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Background: Coeliac disease is a substantially underdiagnosed disorder, with clinical testing currently guided by case finding.

Aim: To determine the presence of indications for diagnostic testing and frequency of clinical testing in undiagnosed coeliac disease.

Methods: This was a case-control study of adults without prior diagnosis of coeliac disease. Read More

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http://dx.doi.org/10.1111/apt.14625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910260PMC
May 2018
3 Reads