3,250 results match your criteria Dermatitis Herpetiformis


Overall and Cause-Specific Mortality in Adult Celiac Disease and Dermatitis Herpetiformis Diagnosed in the 21st Century.

Am J Gastroenterol 2020 May 20. Epub 2020 May 20.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Introduction: We assessed whether celiac disease-associated mortality is increased in Finland among patients diagnosed in the 21st century, given recent improvements in diagnostic and treatment facilities.

Methods: Biopsy-proven patients with celiac disease (Marsh III) and dermatitis herpetiformis aged 20-79 years (median 50 years) diagnosed 2005-2014 (n = 12,803) were identified from the national dietary grant registry. Dates and causes of death were obtained from Statistics Finland. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000665DOI Listing

Eosinophilic Dermatoses: Recognition and Management.

Am J Clin Dermatol 2020 May 11. Epub 2020 May 11.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Eosinophilic dermatoses encompass a broad spectrum of diseases of different etiologies hallmarked by eosinophilic infiltration of the skin and/or mucous membranes, with or without associated blood eosinophilia. The wide range of dermatological manifestations of this spectrum, including nodules and plaques, pustules, blisters, ulcers, and urticarial lesions, is reflected in a non-univocal classification system. We identified six groups of eosinophilic dermatoses based on the predominant anatomic level of involvement: (1) epidermal; (2) of the dermal-epidermal junction; (3) dermal; (4) of the hypodermis and muscle fascia; (5) of the pilosebaceous unit; and (6) vascular/perivascular. Read More

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http://dx.doi.org/10.1007/s40257-020-00520-4DOI Listing

Expert recommendations for the management of autoimmune bullous diseases during the COVID-19 pandemic.

J Eur Acad Dermatol Venereol 2020 Apr 25. Epub 2020 Apr 25.

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, USA.

Autoimmune bullous diseases (AIBDs) are potentially life-threatening disorders comprising intra-epidermal/epithelial (pemphigus) and sub-epidermal/epithelial blistering diseases (pemphigoid and dermatitis herpetiformis). Corticosteroids and non-steroid immunomodulatory agents are the mainstays of treatment. Treatment can be challenging particularly in pemphigus, mucous membrane pemphigoid, and epidermolysis bullosa acquisita which may require more intense immunosuppressive approaches. Read More

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http://dx.doi.org/10.1111/jdv.16525DOI Listing

Consensus on the Clinical Approach to Moderate-to-Severe Atopic Dermatitis in Spain: A Delphi Survey.

Dermatol Res Pract 2020 7;2020:1524293. Epub 2020 Apr 7.

Section of Allergy, Hospital Clinic i Provincial de Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.

Background: The purpose of this study was to gather information on the current assessment and management of patients with moderate-to-severe AD in routine daily practice.

Methods: A cross-sectional two-round Delphi survey with the participation of dermatologists and allergologists throughout Spain was conducted. They completed a 46-item questionnaire, and consensus was defined when responses of ≥80% of participants coincided in the categories of a 5-point Likert scale for that item. Read More

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http://dx.doi.org/10.1155/2020/1524293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166259PMC

The Long-Term Safety and Quality of Life Effects of Oats in Dermatitis Herpetiformis.

Nutrients 2020 Apr 11;12(4). Epub 2020 Apr 11.

Department of Dermatology, Tampere University Hospital, 33521 Tampere, Finland.

The treatment of choice for dermatitis herpetiformis (DH), a cutaneous manifestation of coeliac disease, is a life-long gluten-free diet (GFD). In a GFD, wheat, rye and barley should be strictly avoided, but the role of oats is more controversial. This study aimed to investigate the safety and long-term quality of life and health effects of oat consumption in 312 long-term treated DH patients. Read More

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http://dx.doi.org/10.3390/nu12041060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230654PMC

Putative Abscopal Effect in Three Patients Treated by Combined Radiotherapy and Modulated Electrohyperthermia.

Front Oncol 2020 10;10:254. Epub 2020 Mar 10.

Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

True abscopal responses from radiation therapy are extremely rare; the combination of immune checkpoint inhibitors with radiation therapy has led to more reports of the abscopal effect, but even in this setting, the genuine magnitude remains unknown and is still considered generally uncommon. We report the occurrence of what appears to be putative, durable abscopal tumor responses with associated auto-immune systemic reactions resulting from the combination of local radiotherapy (RT) and modulated electrohyperthermia (mEHT). Data from advanced cancer patients treated palliatively with RT and mEHT between January and December 2017 were collected as part of a post-marketing safety monitoring program of mEHT therapy. Read More

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http://dx.doi.org/10.3389/fonc.2020.00254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077340PMC

Female Patients with Dermatitis Herpetiformis Show a Reduced Diagnostic Delay and Have Higher Sensitivity Rates at Autoantibody Testing for Celiac Disease.

Biomed Res Int 2019 29;2019:6307035. Epub 2019 Dec 29.

GISED (Italian Group for Epidemiological Studies in Dermatology) Group and Italian Group for Cutaneous Immunopathology, Italy.

Objective: Our objective was to characterize the demographic information, clinical features, and laboratory data of patients with dermatitis herpetiformis (DH).

Methods: In this multicentre cross-sectional study, consecutive patients with a new diagnosis of DH that referred to nine different Italian centers between 2011 and 2016 were characterized assessing demographic, clinical and laboratory findings, and evaluating gender and age differences across selected variables.

Results: A total of 151 patients were included. Read More

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http://dx.doi.org/10.1155/2019/6307035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024079PMC
December 2019

Intestinal TG3- and TG2-Specific Plasma Cell Responses in Dermatitis Herpetiformis Patients Undergoing a Gluten Challenge.

Nutrients 2020 Feb 13;12(2). Epub 2020 Feb 13.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.

Dermatitis herpetiformis (DH), a cutaneous manifestation of coeliac disease, is characterized by transglutaminase (TG) 3-targeted dermal immunoglobulin A (IgA) deposits. The treatment for DH is the same as for coeliac disease, namely a life-long gluten-free diet. DH patients typically have gluten-dependent circulating autoantibodies targeting TG3 and TG2, and plasma cells secreting such autoantibodies have been detected in the small intestinal mucosa. Read More

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http://dx.doi.org/10.3390/nu12020467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071213PMC
February 2020

Current Concepts of Dermatitis Herpetiformis.

Acta Derm Venereol 2020 02 12;100(5):adv00056. Epub 2020 Feb 12.

Department of Dermatology, Tampere University Hospital, PO Box 2000, FIN-33521 Tampere, Finland.

Dermatitis herpetiformis (DH) is an autoimmune skin disease that causes itchy, blistering rash, typically on the elbows, knees and buttocks. DH and coeliac disease share the same genetic background, gluten-dependent enteropathy and antibody response against tissue transglutaminase. DH is currently considered a cutaneous manifestation of coeliac disease, and the prevailing hypothesis is that DH develops as a late manifestation of subclinical coeliac disease. Read More

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http://dx.doi.org/10.2340/00015555-3401DOI Listing
February 2020

Gliadin-Induced Ex Vivo T-Cell Response in Dermatitis Herpetiformis: A Predictor of Clinical Relapse on Gluten Challenge?

J Invest Dermatol 2020 Feb 7. Epub 2020 Feb 7.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.12.038DOI Listing
February 2020

An update on direct immunofluorescence for diagnosing dermatitis herpetiformis.

Postepy Dermatol Alergol 2019 Dec 30;36(6):655-658. Epub 2019 Dec 30.

Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. Read More

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http://dx.doi.org/10.5114/ada.2019.91415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986300PMC
December 2019

Update on the use of dapsone in dermatology.

Int J Dermatol 2020 Jan 7. Epub 2020 Jan 7.

Department of Dermatology, American University of Beirut, Beirut, Lebanon.

Dapsone (4,4'-diaminodiphenylsulfone) is the only remaining sulfone used in anthropoid therapeutics and is commercially available as an oral formulation, an inhaled preparation, and a 5% or 7.5% cream. Dapsone has antimicrobial effects stemming from its sulfonamide-like ability to inhibit the synthesis of dihydrofolic acid. Read More

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http://dx.doi.org/10.1111/ijd.14761DOI Listing
January 2020

Deciphering crucial genes in coeliac disease by bioinformatics analysis.

Autoimmunity 2020 03 6;53(2):102-113. Epub 2019 Dec 6.

Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.

Coeliac disease (CD) is a chronic autoimmune disease that is characterized by malabsorption in sensitive individuals. CD is triggered by the ingestion of grains containing gluten. CD is concomitant with several other disorders, including dermatitis herpetiformis, selective IgA deficiency, thyroid disorders, diabetes mellitus, various connective tissue disorders, inflammatory bowel disease, and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1080/08916934.2019.1698552DOI Listing
March 2020
5 Reads
2.714 Impact Factor

Gender-Related Differences in Celiac Patients at Diagnosis.

Arch Med Res 2019 10 27;50(7):437-441. Epub 2019 Nov 27.

Mackenzie Evangelical School of Medicine Paraná, Curitiba, Brazil; Clinic Hospital, Federal University of Paraná, Curitiba, Parana, Brazil; Department of Medicine, Positivo University, Curitiba, Brazil. Electronic address:

Background: Clinical presentation of celiac disease (CD) in terms of gender have demonstrated differences between symptoms among women and men. This study evaluated the differences in the clinical presentation of CD among Brazilian men and women at the time of diagnosis.

Material And Methods: We investigated data on symptoms and clinical signs of 240 patients (80 [33. Read More

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http://dx.doi.org/10.1016/j.arcmed.2019.11.007DOI Listing
October 2019

Dermatitis herpetiformis in an adolescent patient.

An Bras Dermatol 2019;94(4):495-496. Epub 2019 Oct 17.

Dermatology and Venereology Service, Hospital Garcia de Orta, Almada, Portugal.

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http://dx.doi.org/10.1590/abd1806-4841.20198227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007020PMC
November 2019
1 Read

Dapsone-induced hepatic complications: it's time to think beyond methemoglobinemia.

Drug Chem Toxicol 2019 Oct 21:1-4. Epub 2019 Oct 21.

Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences , Chennai , India.

Drug-induced liver injury is an important cause of hepatotoxicity and poses a challenging clinical problem with respect to both diagnosis and management. Patients susceptible to hepatotoxicity on exposure to dapsone is constantly on the rise. Dapsone (4,4'-diaminodiphenylsulfone) is clinically used alone or in combination with rifampicin for the treatment of a variety of dermatological disorders such as acne, dermatitis herpetiformis, psoriasis, infections, leprosy and pneumonia in AIDS patients. Read More

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http://dx.doi.org/10.1080/01480545.2019.1679829DOI Listing
October 2019
8 Reads

Spurious HbA1c results in patients with diabetes treated with dapsone.

Endocrinol Diabetes Metab Case Rep 2019 Sep 27;2019. Epub 2019 Sep 27.

Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland.

Summary: Measurement of glycated haemoglobin (HbA1c) has been utilised in assessing long-term control of blood glucose in patients with diabetes, as well as diagnosing diabetes and identifying patients at increased risk of developing diabetes in the future. HbA1c reflects the level of blood glucose to which the erythrocyte has been exposed during its lifespan, and there are a number of clinical situations affecting the erythrocyte life span in which HbA1c values may be spuriously high or low and therefore not reflective of the true level of glucose control. In the present case series, we describe the particulars of three patients with diabetes who had spuriously low HbA1c levels as a result of dapsone usage. Read More

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http://dx.doi.org/10.1530/EDM-19-0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765317PMC
September 2019
4 Reads

Alopecia in Autoimmune Blistering Diseases: A Systematic Review of Pathogenesis and Clinical Features of Disease.

Skin Appendage Disord 2019 Aug 10;5(5):263-275. Epub 2019 Jul 10.

Department of Dermatology, St. George Hospital, Sydney, New South Wales, Australia.

Background: Autoimmune blistering diseases (AIBD) are characterised by the body's production of autoantibodies against structural proteins in the epidermis and/or the basement membrane on cutaneous and mucosal surfaces. Alopecia is a complication of AIBD that has generally been overlooked in patients with severe blistering diseases because it is regarded as a cosmetic issue. Yet recent research into quality of life tools has found that stigmatisation by appearance plays a significant role in blistering diseases. Read More

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http://dx.doi.org/10.1159/000496836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751435PMC
August 2019
7 Reads

Bullous Diseases in Children: A Review of Clinical Features and Treatment Options.

Paediatr Drugs 2019 Oct;21(5):345-356

Department of Dermatology, University of Minnesota, 240 Phillips-Wangensteen Building, 516 Delaware Street Southeast, Minneapolis, MN, 55455, USA.

Bullous diseases are uncommon in children; however, as they have the potential to affect quality of life, occasionally have long-term side effects in the setting of scarring processes, and carry a rare risk of underlying malignancy [e.g., with paraneoplastic pemphigus (PNP)], knowledge of their clinical presentation and treatment options is essential. Read More

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http://dx.doi.org/10.1007/s40272-019-00349-3DOI Listing
October 2019
5 Reads

Lichen planopilaris and dermatitis herpetiformis: a fortuitous association?

Eur J Dermatol 2019 Aug;29(4):426-428

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico,, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1684/ejd.2019.3570DOI Listing
August 2019
3 Reads

Dermatitis herpetiformis resistant to dapsone due to dietary iodide ingestion.

JAAD Case Rep 2019 Aug 5;5(8):713-714. Epub 2019 Aug 5.

Department of Dermatology, University of Utah, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.jdcr.2019.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698721PMC
August 2019
2 Reads

Experimental dapsone administration induces infertility in male Wistar rats: Mechanisms and clinical implications.

Pathophysiology 2019 Sep - Dec;26(3-4):289-303. Epub 2019 Jul 30.

Department of Physiology, University of Ibadan, 900001 Ibadan, Nigeria. Electronic address:

Dapsone (4, 4'-diaminodiphenylsulfone, DDS) is a potent anti-inflammatory and antibacterial compound which has been used in the treatment of leprosy, vasculitis and dermatitis herpetiformis, lupus erythematosus profundus and even as an antimalarial in combination with proguanil. This study investigated the effect of the administration of dapsone on the reproductive activities of male rats using in vivo and in vitro techniques. In the in vivo study, dapsone was administered orally to male Wistar rats for 5 days or 6 weeks after which their body weight, relative reproductive organ weights, sperm parameters and reproductive hormones were determined while testicular and epididymal histology were also assessed. Read More

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http://dx.doi.org/10.1016/j.pathophys.2019.07.004DOI Listing
July 2019
3 Reads

Atypical manifestations of disseminated cutaneous botryomycosis mimicking dermatitis herpetiformis in an immunocompetent adult woman.

Indian J Dermatol Venereol Leprol 2019 Sep-Oct;85(5):511-513

Department of Dermatology, Max Smart Hospital, Saket, New Delhi, India.

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http://www.ijdvl.com/text.asp?2019/85/5/511/263914
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http://dx.doi.org/10.4103/ijdvl.IJDVL_845_18DOI Listing
February 2020
3 Reads

Evaluation of serum cytokine and chemokine levels in dermatitis herpetiformis: a systematic review and meta-analysis.

Immunol Res 2019 06;67(2-3):265-266

Department of Dermatology, University of Illinois at Chicago, Chicago, IL, 60607, USA.

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http://dx.doi.org/10.1007/s12026-019-09086-8DOI Listing
June 2019
2 Reads

Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review.

Front Immunol 2019 26;10:1477. Epub 2019 Jun 26.

Department of Pathology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands.

Autoimmune bullous dermatoses (AIBD) are characterized by circulating autoantibodies that are either directed against epidermal antigens or deposited as immune complexes in the basement membrane zone (BMZ). The complement system (CS) can be activated by autoantibodies, thereby triggering activation of specific complement pathways. Local complement activation induces a pathogenic inflammatory response that eventually results in the formation of a sub- or intraepidermal blister. Read More

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http://dx.doi.org/10.3389/fimmu.2019.01477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606728PMC
June 2019
3 Reads

Diagnostic criteria for pemphigus herpetiformis.

Int J Dermatol 2019 11 8;58(11):e216-e217. Epub 2019 Jul 8.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1111/ijd.14584DOI Listing
November 2019
4 Reads

Coagulation and Skin Autoimmunity.

Front Immunol 2019 20;10:1407. Epub 2019 Jun 20.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

Several lines of evidence indicate that the immune system, inflammation, and coagulation are simultaneously activated in autoimmune and immune-mediated skin diseases. Pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha induce the expression of the main initiator of coagulation, i.e. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01407
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http://dx.doi.org/10.3389/fimmu.2019.01407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596352PMC
June 2019
4 Reads

Risk of fractures in dermatitis herpetiformis and coeliac disease: a register-based study.

Scand J Gastroenterol 2019 Jul 7;54(7):843-848. Epub 2019 Jul 7.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University , Tampere , Finland.

Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease. Bone fracture risk is increased in coeliac disease, but little knowledge exists about bone complications in DH. This study aimed to evaluate the risk of hip and other hospital-treated fractures in DH and coeliac disease in a high prevalence area with good adherence to a gluten-free diet. Read More

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http://dx.doi.org/10.1080/00365521.2019.1636132DOI Listing
July 2019
3 Reads

Could anti-glycan antibodies be useful in dermatitis herpetiformis?

Eur J Dermatol 2019 Jun;29(3):322-323

Department of Health Sciences, Section of Dermatology, University of Genoa, Genoa.

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http://dx.doi.org/10.1684/ejd.2019.3542DOI Listing
June 2019
5 Reads

Dermatitis Herpetiformis: Novel Perspectives.

Front Immunol 2019 11;10:1290. Epub 2019 Jun 11.

Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.

Dermatitis herpetiformis (DH) is an inflammatory disease of the skin, considered the specific cutaneous manifestation of celiac disease (CD). Both DH and CD occur in gluten-sensitive individuals, share the same Human Leukocyte Antigen (HLA) haplotypes (DQ2 and DQ8), and improve following the administration of a gluten-free diet. Moreover, almost all DH patients show typical CD alterations at the small bowel biopsy, ranging from villous atrophy to augmented presence of intraepithelial lymphocytes, as well as the generation of circulating autoantibodies against tissue transglutaminase (tTG). Read More

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http://dx.doi.org/10.3389/fimmu.2019.01290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579917PMC
June 2019
7 Reads

Sulfasalazine-induced generalized vitiligo in a patient with dermatitis herpetiformis and celiac disease.

Dermatol Ther 2019 09 8;32(5):e13007. Epub 2019 Jul 8.

Department of Dermatology, VA Boston Healthcare System, Boston, Massachusetts.

Vitiligo is an acquired idiopathic pigmentary skin disorder characterized by the development of white macules and patches due to the loss of functioning melanocytes. In this report, we describe a case of a patient with a longstanding history of dermatitis herpetiformis (DH) and celiac disease that developed rapidly progressing, biopsy-confirmed generalized vitiligo after 11 months of treatment with anti-inflammatory medication sulfasalazine, prescribed for the patient's DH. To the best of our knowledge, this is the first case report which has demonstrated the possible biochemical pathways, triggered by sulfasalazine, in the development of vitiligo. Read More

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http://dx.doi.org/10.1111/dth.13007DOI Listing
September 2019
8 Reads

European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders.

United European Gastroenterol J 2019 06 13;7(5):583-613. Epub 2019 Apr 13.

Department of Gastroenterology, Oslo University Hospital Rikshospitalet, Oslo, Norway.

This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults and children. There has been a substantial increase in the prevalence of CD over the last 50 years and many patients remain undiagnosed. Diagnostic testing, including serology and biopsy, should be performed on a gluten-containing diet. Read More

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http://journals.sagepub.com/doi/10.1177/2050640619844125
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http://dx.doi.org/10.1177/2050640619844125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545713PMC
June 2019
5 Reads

Consensus on the treatment of autoimmune bullous dermatoses: dermatitis herpetiformis and linear IgA bullous dermatosis - Brazilian Society of Dermatology.

An Bras Dermatol 2019 Apr 3;94(2 Suppl 1):48-55. Epub 2019 Jun 3.

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Dermatitis herpetiformis and linear IgA bullous dermatosis are autoimmune diseases that present with pruritic urticarial papules and plaques, with formation of vesicles and blisters of subepidermal location, mediated by IgA antibodies. Mucosal lesions are present only in linear IgA bullous dermatosis. The elaboration of this consensus consisted of a brief presentation of the different aspects of these dermatoses and, above all, of an updated literature review on the various therapeutic options that were discussed and compared with the authors' experience, aiming at the treatment orientation of these diseases in Brazil. Read More

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http://dx.doi.org/10.1590/abd1806-4841.2019940208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544034PMC
April 2019
23 Reads

Fibrillar-type dermatitis herpetiformis.

Eur J Dermatol 2019 Apr;29(2):115-120

Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama.

Dermatitis herpetiformis (DH) is a pruritic papulovesicular disease that is relatively common in Caucasian populations, and was first reported by Louis Duhring. It is characterized by granular IgA deposition in the dermal-epidermal junction and gluten-sensitive enteropathy (GSE) associated with human leukocyte antigen-DQ2/DQ8 haplotype. In contrast, DH is rare in Japan, and Japanese DH patients occasionally show unique features, including a high frequency of fibrillar IgA deposition in the papillary dermis, and rare occurrence of GSE. Read More

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http://dx.doi.org/10.1684/ejd.2019.3533DOI Listing
April 2019
7 Reads

Celiac-Related Autoantibodies and IL-17A in Bulgarian Patients with Dermatitis Herpetiformis: A Cross-Sectional Study.

Medicina (Kaunas) 2019 May 15;55(5). Epub 2019 May 15.

Department of Dermatology, Faculty of Medicine, Medical University-Sofia, 1431 Sofia, Bulgaria.

: Dermatitis herpetiformis (DH) is a blistering dermatosis, which shares common immunologic features with celiac disease (CD). The aim of the present study was to explore the performance of a panel of CD-related antibodies and IL-17A in Bulgarian patients with DH. Serum samples from 26 DH patients at mean age 53 ± 15 years and 20 healthy controls were assessed for anti-tissue transglutaminase (anti-tTG), anti-deamidated gliadin peptides (anti-DGP), anti-actin antibodies (AAA), and IL-17A by enzyme linked immuno-sorbent assay (ELISA), as well as anti-tTG, anti-gliadin (AGA), and anti-Saccharomyces cerevisiae antibodies (ASCA) using immunoblot. Read More

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http://dx.doi.org/10.3390/medicina55050136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572648PMC
May 2019
9 Reads
0.508 Impact Factor

Dermatitis herpetiformis.

Authors:
T T Salmi

Clin Exp Dermatol 2019 Oct 15;44(7):728-731. Epub 2019 May 15.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease (CD), which causes an itching and blistering rash, typically on the elbows, knees and buttocks. DH and CD share a similar genetic background, small bowel mucosal alterations, and an autoimmune response against tissue transglutaminase in the serum and small bowel. DH is typically diagnosed during adulthood, and it is slightly more common among males than females. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ced.13992
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http://dx.doi.org/10.1111/ced.13992DOI Listing
October 2019
17 Reads

Review of autoimmune blistering diseases: the Pemphigoid diseases.

J Eur Acad Dermatol Venereol 2019 Sep 11;33(9):1685-1694. Epub 2019 Jul 11.

St George Hospital, Sydney, Australia.

Autoimmune Blistering Diseases of the Pemphigoid type is characterised by sub-epidermal blisters (SEB) with circulating autoantibodies against components of the basement membrane zone (BMZ). The main disorders to date include bullous pemphigoid (BP), pemphigoid gestationis, mucous membrane pemphigoid (MMP), epidermolysis bullosa acquisita (EBA), linear IgA disease (LABD), dermatitis herpetiformis (DH), lichen planus pemphigoides and bullous lupus. This is in contrast to pemphigus and related disorders, which demonstrate intraepidermal acantholysis and a positive Nikolsky sign. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15679
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http://dx.doi.org/10.1111/jdv.15679DOI Listing
September 2019
45 Reads

C4d immunohistochemical stain of formalin-fixed paraffin-embedded tissue as a sensitive method in the diagnosis of bullous pemphigoid.

J Cutan Pathol 2019 Oct 24;46(10):723-728. Epub 2019 May 24.

Department of Dermatology, Razi Hospital,Tehran University of Medical Sciences, Tehran, Iran.

Background: Bullous pemphigoid (BP) is the most common type of subepidermal bullous disease. Direct immunofluorescence (DIF) is the gold standard for diagnosis, but it requires a fresh tissue specimen. This study was conducted to evaluate the accuracy of using immunohistochemical (IHC) analysis for the detection of C4d in paraffin-embedded tissue of BP cases. Read More

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http://dx.doi.org/10.1111/cup.13490DOI Listing
October 2019
12 Reads
1.560 Impact Factor

Autoimmune Diseases and Gastric Cancer Risk: A Systematic Review and Meta-Analysis.

Cancer Res Treat 2019 Jul 3;51(3):841-850. Epub 2019 May 3.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Purpose: Autoimmunity is an alternative etiology of gastric inflammation, the initiating event in the gastric carcinogenic cascade. This mechanism may be an increasingly important cause of gastric cancer with the waning prevalence of its primary etiologic factor, chronic Helicobacter pylori infection.

Materials And Methods: PubMed and EMBASE were searched up to September 2018. Read More

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http://www.e-crt.org/journal/view.php?doi=10.4143/crt.2019.1
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http://dx.doi.org/10.4143/crt.2019.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639229PMC
July 2019
31 Reads

MPGN Type 3 Associated with Pemphigus Herpetiformis Mimicking PGNMID and Dermatitis Herpetiformis.

Case Rep Nephrol Dial 2019 Jan-Apr;9(1):15-24. Epub 2019 Mar 21.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

A 45-year-old man suffering from dermal blistering disease with proteinuria and hematuria underwent renal biopsy. The renal biopsy specimen suggested proliferative glomerulonephritis with monoclonal IgG deposits under routine light, immunofluorescence and electron microscopy. The staining for IgG subclasses (IgG1 and IgG2) and κ/λ light chain indicated secondary immune complex type MPGN type 3. Read More

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https://www.karger.com/Article/FullText/498939
Publisher Site
http://dx.doi.org/10.1159/000498939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465718PMC
March 2019
25 Reads

Gluten Challenge Induces Skin and Small Bowel Relapse in Long-Term Gluten-Free Diet-Treated Dermatitis Herpetiformis.

J Invest Dermatol 2019 10 15;139(10):2108-2114. Epub 2019 Apr 15.

Department of Dermatology, Tampere University Hospital, Tampere, Finland; Celiac Disease Research Center, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland. Electronic address:

Dermatitis herpetiformis (DH) is an extraintestinal manifestation of celiac disease causing an itchy, blistering rash. Granular IgA deposits in the skin are pathognomonic for DH, and the treatment of choice is a lifelong gluten-free diet (GFD). Preliminary evidence suggests that there are patients with DH who redevelop gluten tolerance after adherence to a GFD treatment. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1150DOI Listing
October 2019
9 Reads

Metabolic, pharmacokinetic, and toxicological issues surrounding dapsone.

Expert Opin Drug Metab Toxicol 2019 May 19;15(5):367-379. Epub 2019 Apr 19.

a Dermatological Unit, Department of Clinical and Molecular Sciences , Polytechnic Marche University , Ancona , Italy.

Introduction: In their 70-year history, dapsone and other sulfones have been used as both antibacterial and anti-inflammatory agents. Dapsone has been the main active principle in the multidrug regimen recommended by the World Health Organization for the treatment of leprosy. In addition, dapsone has been successfully used to treat a wide range of dermatological and systemic disorders, mostly characterized by neutrophilic and eosinophilic accumulation and infiltration. Read More

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http://dx.doi.org/10.1080/17425255.2019.1600670DOI Listing
May 2019
9 Reads

[Autoimmune blistering dermatoses in children].

Hautarzt 2019 Apr;70(4):277-282

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

Autoimmune blistering skin disorders represent a rare group of autoantibody-induced dermatoses against desmosomal and hemidesmosomal molecules. The common age of onset for pemphigus and pemphigoid, as well as dermatitis herpetiformis, encompasses the adult age, but all these disorders can be observed neonatally and/or during childhood. If the disease occurs postpartum or neonatally, physicians should consider transplacental transmission of pathogenic maternal immunoglobulin G (IgG)-autoantibodies, and both mother and child should be included in the diagnostic work up. Read More

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http://dx.doi.org/10.1007/s00105-019-4379-7DOI Listing
April 2019
30 Reads

Dermatitis herpetiformis arising within vitiligo in a patient with autoimmune polyendocrine syndrome type 3.

Int J Dermatol 2019 Jun 28;58(6):e123-e125. Epub 2019 Mar 28.

Department of Dermatology, Allergology and Venereology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/ijd.14446DOI Listing
June 2019
7 Reads

Clinical, pathologic, and immunologic features of pemphigus herpetiformis: a literature review and proposed diagnostic criteria.

Int J Dermatol 2019 Sep 22;58(9):997-1007. Epub 2019 Mar 22.

Department of Dermatology, Mayo Clinic, Jacksonville, FL, USA.

Pemphigus herpetiformis (PH), a rare type of pemphigus, is characterized by immunologic findings consistent with pemphigus but with a unique clinical and pathologic presentation. PH was first described as resembling dermatitis herpetiformis clinically, but because of its variable presentation, it can also resemble linear immunoglobulin A bullous dermatosis and bullous pemphigoid. We reviewed reported cases to analyze the most frequent clinical, pathologic, and immunologic characteristics and to propose corresponding diagnostic criteria. Read More

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http://dx.doi.org/10.1111/ijd.14395DOI Listing
September 2019
7 Reads

DNA damage in human skin fibroblasts from patients with dermatitis herpetiformis.

Eur J Dermatol 2019 Apr;29(2):167-173

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano,, Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico,, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.

Dermatitis herpetiformis (DH) and celiac disease (CD) are considered to be autoimmune diseases that share a specific trigger (gluten) and a common genetic background (HLA-DQ2/DQ8). However, the pathogenesis of DH is not yet fully understood and no data are available regarding a possible role of fibroblasts in this disease. The aim of this study was to assess baseline DNA damage in fibroblasts in DH-diagnosed patients vs. Read More

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http://dx.doi.org/10.1684/ejd.2019.3528DOI Listing
April 2019
20 Reads