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    2843 results match your criteria Dermatitis Exfoliative

    1 OF 57

    An exploratory factor analysis of the spontaneous reporting of severe cutaneous adverse reactions.
    Ther Adv Drug Saf 2017 Jan 29;8(1):4-16. Epub 2016 Nov 29.
    Pfizer Inc., New York, NY, USA.
    Background: Severe cutaneous adverse reactions (SCARs) are prominent in pharmacovigilance (PhV). They have some commonalities such as nonimmediate nature and T-cell mediation and rare overlap syndromes have been documented, most commonly involving acute generalized exanthematous pustulosis (AGEP) and drug rash with eosinophilia and systemic symptoms (DRESS), and DRESS and toxic epidermal necrolysis (TEN). However, they display diverse clinical phenotypes and variations in specific T-cell immune response profiles, plus some specific genotype-phenotype associations. Read More

    Cutaneous Presentation of Angioimmunoblastic T-Cell Lymphoma: A Harbinger of Poor Prognosis?
    Skinmed 2016 1;14(6):469-471. Epub 2016 Dec 1.
    Singapore General Hospital, Singapore.
    A 62-year-old woman presented with a 2-year history of extensive, pruritic dermatosis over her face, trunk, and limbs. She was initially treated for psoriasis with methotrexate 5 mg twice weekly and topical clobetasol cream; however, her condition worsened, and she was admitted for generalized exfoliative dermatitis. Examination showed generalized erythema and scaling affecting her face (Figure 1A), chest (Figure 1B), back, and limbs. Read More

    Epidermal programmed cell death-ligand 1 expression in TEN associated with nivolumab therapy.
    J Cutan Pathol 2016 Dec 21. Epub 2016 Dec 21.
    Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, Florida.
    Nivolumab is a programmed cell death receptor-1 (PD-1) antibody used in the treatment of metastatic or unresectable melanoma. Cutaneous reactions are the most common adverse events reported with these agents and are rarely severe or life-threatening. Here we present a case report describing the clinicopathological findings of a patient with a fatal toxic epidermal necrolysis (TEN) eruption associated with use of nivolumab for treatment of metastatic melanoma. Read More

    Erythrodermic Psoriasis Treated with Apremilast.
    Dermatol Reports 2016 Jun 19;8(1):6599. Epub 2016 Sep 19.
    Department of Medicine, Loma Linda University School of Medicine; Department of Medicine, VA Loma Linda Healthcare System, Loma Linda, CA, USA.
    Erythroderma is a rare potentially deadly exfoliative dermatitis characterized by diffuse cutaneous erythema which may be associated with multi-organ dysfunction. Therefore, it is imperative to recognize and treat it promptly. Erythrodermic psoriasis is the most common form of erythroderma. Read More

    Seroprevalence of Canine Leishmaniasis in Northern Cyprus.
    Turkiye Parazitol Derg 2016 Sep;40(3):117-120
    Clinic of PetZone, Nicosia, Northern Cyprus.
    Objective: Canine leishmaniasis (CanL) is an important public and veterinary health problem in Mediterranean Basin countries. In this study, we aimed to determine the seroprevalence of CanL in several provinces of Northern Cyprus.

    Methods: The seroprevalence of CanL was determined by the indirect fluorescent antibody (IFA) test in dog sera. Read More

    Eccrine Syringofibroadenoma in a Patient with Long-Standing Exfoliative Dermatitis.
    Ann Dermatol 2016 Dec 23;28(6):765-768. Epub 2016 Nov 23.
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    Eccrine syringofibroadenoma (ESFA) is a rare benign cutaneous adnexal lesion characterized by a hyperplastic epithelium and eccrine ductal differentiation. In the present case, a 73-year-old Korean male presented with symmetrical numerous widespread, pinkish nodules with a cobblestone appearance over both legs for 2 years. He had a history of generalized erythematous scaly patches over his entire body for 20 years. Read More

    Non-dermatophyte Dermatoses Mimicking Dermatophytoses in Animals.
    Mycopathologia 2017 Feb 16;182(1-2):113-126. Epub 2016 Nov 16.
    UP Interactions Cellules Environnement, VetAgro Sup, Univ Lyon, 69280, Marcy l'Etoile, France.
    Dermatophytoses in animals are fungal diseases of the skin caused by dermatophyte fungi of the genus Microsporum or Trichophyton. Because the infection is generally follicular, the most common clinical sign is one or many circular areas of alopecia with variable erythema, scaling and crusting, and the primary differential diagnoses are follicular infections, such as bacterial folliculitis and demodicosis. Although dermatophyte folliculitis or ringworm is the most commonly observed lesion of dermatophytoses in animals, other presentations may be observed according to the host species and the dermatophyte involved: dermatophyte folliculitis or ringworm, scaling and crusting in dermatophytosis due to Microsporum persicolor, nodule in case of kerion or mycetoma, matted hairs, seborrheic dermatosis or miliary dermatitis in cats, generalized exfoliative dermatoses in dogs, cats and horses, superficial non-follicular pustules, papules and macules in the Devon Rex cat, pruritic dermatophytoses in dogs, cats and horses, and onychomycosis in dogs, cats and horses. Read More

    Glycerin Borax Treatment of Exfoliative Cheilitis Induced by Sodium Lauryl Sulfate: a Case Report.
    Acta Stomatol Croat 2016 Jun;50(2):158-161
    Oral Medicine Department, Faculty of Dentistry Chulalongkorn University
Bangkok 10330, Thailand.
    This paper reports on the results of a case study of a 19-year-old female who presented to the Oral Medicine clinic with a chief complaint of scaly and peeling lips. The lesions had persisted on her lips for more than 7 years and were refractory to previous treatment. Her physician's diagnosis was contact dermatitis. Read More

    Slow desensitization of imatinib-induced nonimmediate reactions and dynamic changes of drug-specific CD4(+)CD25(+)CD134(+) lymphocytes.
    Ann Allergy Asthma Immunol 2016 Nov 24;117(5):514-519. Epub 2016 Oct 24.
    King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
    Background: Imatinib is a tyrosine kinase inhibitor indicated for the treatment of gastrointestinal stromal tumors (GISTs) and certain neoplastic diseases; however, nonimmediate adverse reactions are common.

    Objective: To describe the process of imatinib slow desensitization in patients who experienced nonimmediate reactions to imatinib and the dynamic change in drug-specific CD4(+)CD25(+)CD134(+) T-lymphocyte percentages.

    Methods: Five patients diagnosed as having GISTs and with a recent history of imatinib-induced nonimmediate reactions (maculopapular exanthema with eosinophilia, exfoliative dermatitis, palmar-plantar erythrodysesthesia, and drug rash with eosinophilia and systemic symptoms) were desensitized using a slow desensitization protocol. Read More

    Oxcarbazepine-induced drug rash with eosinophilia and systemic symptoms syndrome presenting as exfoliative dermatitis.
    J Pharmacol Pharmacother 2016 Jul-Sep;7(3):142-5
    Department of Dermatology, Silchar Medical College, Silchar, Assam, India.
    Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a type of severe adverse cutaneous drug reaction characterized by fever, skin eruption, hematological abnormalities, and internal organ involvement. Although anticonvulsant drugs are mainly implicated in DRESS, newer anticonvulsants such as oxcarbazepine-induced definite cases of DRESS syndrome are rare and oxcarbazepine-induced DRESS syndrome presenting as exfoliative dermatitis is even rarer. We report a case of a 35-year-old male who developed DRESS syndrome presenting as exfoliative dermatitis after taking oxcarbazepine for 3 weeks. Read More

    Proposed ICDRG Classification of the Clinical Presentation of Contact Allergy.
    Dermatitis 2016 Sep-Oct;27(5):248-58
    From the *Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; †Allergy Center and Department of Dermatology, University Hospital, Republic University of Uruguay, Montevideo; ‡Department of Dermatology and Allergy Center, Center for Innovative Medical Technology, Institute of Clinical Research, University of Southern Denmark, Odense; §Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden; ∥Department of Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Germany; ¶Department of Dermatology, University Hospital Jena, Germany; #Department of Dermatology, National Skin Centre, Singapore; **Contact Allergy Unit, Department of Dermatology, University Hospital KU Leuven, Belgium; ††MGM Medical College, Kamothe, Mumbai, India; ‡‡Department of Dermatology, Catholic University of Louvain, Brussels, Belgium; §§Department of Dermatology, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul; ∥∥Department of Dermatology, UCSF School of Medicine, San Francisco, CA; ¶¶Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ##Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation, Melbourne, Victoria, Australia; ***Institute of Dermatology, Bangkok, Thailand; †††Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal General Hospital, Quebec, Canada; ‡‡‡Dermatologic Department, Division of Medicine, Phramongkutklao Hospital, Bangkok, Thailand; and §§§Department of Cutaneous Allergy, St. John's Institute of Dermatology, King's College, Guy's Hospital, London, United Kingdom.
    The International Contact Dermatitis Research Group proposes a classification for the clinical presentation of contact allergy. The classification is based primarily on the mode of clinical presentation. The categories are direct exposure/contact dermatitis, mimicking or exacerbation of preexisting eczema, multifactorial dermatitis including allergic contact dermatitis, by proxy, mimicking angioedema, airborne contact dermatitis, photo-induced contact dermatitis, systemic contact dermatitis, noneczematous contact dermatitis, contact urticaria, protein contact dermatitis, respiratory/mucosal symptoms, oral contact dermatitis, erythroderma/exfoliative dermatitis, minor forms of presentation, and extracutaneous manifestations. Read More

    Drug induced exfoliative dermatitis: state of the art.
    Clin Mol Allergy 2016 22;14. Epub 2016 Aug 22.
    Department of Allergy and Clinical Immunology, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy ; Vita-Salute San Raffaele University, Milan, Italy.
    Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. Read More

    Prognosis after Hospitalization for Erythroderma.
    Acta Derm Venereol 2016 Nov;96(7):959-962
    Department of Dermato-Allergology, Herlev and Gentofte Hospital, DK-2900 Hellerup, Denmark.
    Erythrodermic psoriasis (EP) and erythroderma exfoliativa (EE) are acute and potentially life-threatening inflammatory reactions. We estimated hazard ratios (HRs) of 3-year mortality following hospitalization for EP or EE compared with general population controls, patients hospitalized for psoriasis vulgaris, and toxic epidermal necrolysis (TEN), respectively. We identified 26 and 48 patients with a first-time hospitalization (1997-2010) for EP and EE, respectively (10 matched population-controls for each patient), 1,998 patients with psoriasis vulgaris, and 60 patients with TEN. Read More

    Erythroderma. A clinical and etiological study of 103 patients.
    J Dermatol Case Rep 2016 Mar 31;10(1):1-9. Epub 2016 Mar 31.
    Department of Dermatology and Venereology, Centro Hospitalar São João EPE, Porto, Portugal;
    Background: Erythroderma is an uncommon and severe dermatological manifestation of a variety of diseases. It is commonly challenging to find the underlying cause.

    Objective: The aim of this study was to analyze the causes of the disease in patients with erythroderma. Read More

    High Procalcitonin Levels in a Newborn with Erythroderma.
    Pediatr Infect Dis J 2016 May;35(5):593-4
    Department of Pediatrics, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain Division of Neonatology, Department of Pediatrics, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain Division of Pediatric Gastroenterology Department of Pediatrics, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.

    Parasite load in intact and ulcerative skin of dogs with leishmaniais.
    Rev Bras Parasitol Vet 2016 Jan-Mar;25(1):127-30. Epub 2016 Mar 18.
    Departamento de Medicina Veterinária, Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
    The skin is the site of inoculation of Leishmania spp. in susceptible hosts, and consequently dermatopathies, especially ulcerative dermatitis, are the main clinical signs observed. The aim of this study was to assess parasitism of the skin (intact and ulcerated) among dogs that were naturally infected by Leishmania spp. Read More

    Proton pump inhibitor-induced exfoliative dermatitis: A case report.
    Exp Ther Med 2016 Feb 8;11(2):543-546. Epub 2015 Dec 8.
    Department of Pharmacy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
    A 74-year-old female patient was admitted to hospital following a road accident with pains in the chest, abdomen, waist, back, nose, left wrist and lower limbs. After 1 week, the patient presented with gastrointestinal bleeding, and thus was treated with protein pump inhibitors (PPIs), including lansoprazole, esomeprazole and omeprazole enteric-coated tablets, in order to inhibit acid secretion and attenuate bleeding. However, the patient developed skin rashes on the chest and right lower limb and foot 28 days following treatment initiation. Read More

    Imatinib mesylate induced erythroderma: A rare case series.
    J Cancer Res Ther 2015 Oct-Dec;11(4):993-6
    Department of Dermatology, Venereology and Leprology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India.
    Imatinib is a tyrosine kinase inhibitor approved as a first line treatment for chronic myeloid leukemia and gastrointestinal stromal tumors. Usually the drug is well-tolerated with hematological adverse effects being most commonly seen. Dermatological side effects are seen in 9. Read More

    [Staphylococcal Scalded Skin Syndrome in a Very Low Birth Weight Premature Infant].
    Z Geburtshilfe Neonatol 2016 Feb 11;220(1):35-8. Epub 2016 Feb 11.
    Neonatologie, Kinderklinik und Poliklinik, Würzburg.
    Introduction: Staphylococcal scalded skin syndrome (SSSS) was often endemic in the past but is nowadays rare. The hematogeneous spread of exfoliative toxins A (ETA) or B (ETB) produced by specific Staphylococcus aureus strains causes a scald-like eruption with disseminated bullous lesions.

    Case Report: A perioral impetigo lesion occurred on day 14 of life in a preterm male infant (1,065 g, 30 weeks of gestational age). Read More

    Ayurvedic management of life-threatening skin emergency erythroderma: A case study.
    Ayu 2015 Jan-Mar;36(1):69-72
    Department of Panchakarma, S.S.S.B. Ayurvedic College and Hospital, Jaipur, Rajasthan, India.
    Erythroderma or generalized exfoliative dermatitis is a skin disorder that requires attention equivalent to medical emergencies. It is more prevalent in male population. It accounts for 35 cases/100,000 cases in dermatologic outpatient departments. Read More

    A rare case of isoniazid-induced erythroderma.
    Indian J Pharmacol 2015 Nov-Dec;47(6):682-4
    Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
    Tuberculosis is a common infectious disease in developing countries. Isoniazid is established the first-line antitubercular drug and an essential component of all antitubercular regimens. Erythroderma caused by isoniazid is an uncommon but serious adverse drug reaction. Read More

    Adverse cutaneous drug reactions in a single quaternary referral hospital.
    Int J Dermatol 2016 Apr 29;55(4):e198-203. Epub 2015 Dec 29.
    Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil.
    Background: Adverse cutaneous drug reactions are frequent in hospital settings and are responsible for increased morbidity, mortality, and socioeconomic costs. The objective of this study was to identify high risk factors in hospitalized patients with adverse cutaneous drug reactions.

    Methods: This descriptive and retrospective study was performed with data from 117 patients admitted to a quaternary hospital over 44 months. Read More

    Pustular dermatitis in dogs affected by leishmaniosis: 22 cases.
    Vet Dermatol 2016 Feb 2;27(1):9-e4. Epub 2015 Dec 2.
    Clinica Veterinaria Adriatica, Strada Statale Adriatica Nord 50, I-60019, Senigallia (AN), Italy.
    Background: Skin lesions in canine leishmaniosis (CanL) are diverse, including exfoliative, ulcerative, nodular and papular dermatitides. An uncommon pustular form has also been reported.

    Hypotheses/objectives: We hypothesized that CanL infection can produce a pustular reaction pattern in the skin of dogs. Read More

    Trichloroacetic Acid Versus Salicylic Acid in the Treatment of Acne Vulgaris in Dark-Skinned Patients.
    Dermatol Surg 2015 Dec;41(12):1398-404
    Faculty of Medicine, Assiut University, Assiut University Hospital, Assiut, Egypt.
    Background: Treatment options for acne include chemical peeling. Trichloroacetic acid (TCA) has been used for treating acne. The ability of TCA to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. Read More

    Paraneoplastic skin disorders: a review.
    G Ital Dermatol Venereol 2016 Feb 6;151(1):55-76. Epub 2015 Oct 6.
    Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil -
    Paraneoplastic disorders are manifestations of internal malignancies without the direct action of the tumor. Its pathogenesis involves production of substances that interfere with cellular activity of distant tissues. Paraneoplasias may be the first sign of cancer, and clinicians should be familiarized with its manifestations in order to perform an early diagnosis of the underlying neoplasm. Read More

    Erythrodermic mycosis fungoides and Sézary syndrome treated with extracorporeal photopheresis as part of a multimodality regimen: A single-centre experience.
    J Eur Acad Dermatol Venereol 2015 Dec 24;29(12):2382-9. Epub 2015 Aug 24.
    Department of Dermatology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.
    Background: Extracorporeal photopheresis (ECP) is recommended for the erythrodermic mycosis fungoides (MF) and Sezary syndrome (SS) alone or in combination with other therapies. The possibility of a differential response in the blood and skin has hardly been addressed in the literature.

    Objectives: To evaluate the clinical response rate of patients with erythrodermic MF and SS to ECP as part of a multimodality approach and to compare the kinetics of the blood and skin responses in the presence of leukaemic involvement. Read More

    Negative cutaneous effects of medicinal plants in Senegal.
    Br J Dermatol 2015 Jul;173 Suppl 2:26-9
    Department of Dermatology, Aristide Le Dantec Hospital, BP 3001, Dakar, Senegal.
    Use of medicinal plants is common and widespread throughout Africa, including in Senegal. Because efficacy has been demonstrated, public policies have been instituted that have allowed plant-based therapies to have an important role in general primary care. However, little is known about the cutaneous safety of many plant-based therapies. Read More

    LeishVet update and recommendations on feline leishmaniosis.
    Parasit Vectors 2015 Jun 4;8:302. Epub 2015 Jun 4.
    Departament de Medicina i Cirurgia Animal, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, 08193, Spain.
    Limited data is available on feline leishmaniosis (FeL) caused by Leishmania infantum worldwide. The LeishVet group presents in this report a review of the current knowledge on FeL, the epidemiological role of the cat in L. infantum infection, clinical manifestations, and recommendations on diagnosis, treatment and monitoring, prognosis and prevention of infection, in order to standardize the management of this disease in cats. Read More

    Sézary syndrome without erythroderma.
    J Am Acad Dermatol 2015 Jun;72(6):1003-9.e1
    Assistance Publique des Hôpitaux de Paris (APHP), Hôpital Bichat-Claude-Bernard, Dermatology Department, Paris, France; Université Paris 7-Denis Diderot, PRES Sorbonne-Paris Cité, Paris, France.
    Background: Sézary syndrome is a cutaneous T-cell lymphoma characterized by erythroderma and leukemic involvement.

    Objective: We sought to define the clinical, biologic, and histopathologic features of Sézary syndrome without erythroderma.

    Methods: Features of patients with Sézary syndrome and normal-appearing skin or stage-T1 patches, fulfilling Sézary syndrome hematologic criteria and with histologically documented disease in normal-appearing skin were collected. Read More

    Severe scratcher-reaction: an unknown health hazard?
    Dermatol Reports 2015 Mar 27;7(1):5816. Epub 2015 Mar 27.
    Department of Plastic Surgery, Telemark Hospital , Skien, Norway.
    Tattoos are well known to cause skin problems and the number of reported adverse reactions after tattooing has increased. Illegally imported tattoo ink is unrestrained and can contain unknown ingredients and contamination thereby posing a serious health hazard. We present a case illustrating the risk of pronounced phototoxic allergic reaction and other severe complications after using home kit tattoo ink. Read More

    A review of the diagnosis and management of erythroderma (generalized red skin).
    Adv Skin Wound Care 2015 May;28(5):228-36; quiz 237-8
    Nisha Mistry, MD, FRCPC • Dermatologist • Department of Medicine (Dermatology), University of Toronto • Toronto, Ontario, Canada Ambika Gupta • Fourth-year Medical Student • University of Ottawa • Ottawa, Ontario, Canada Afsaneh Alavi, MD, FRCPC • Dermatologist • Department of Medicine (Dermatology), University of Toronto • Toronto, Ontario, Canada R. Gary Sibbald, BSc, MD, MEd, FRCPC(Med)(Derm), FACP, FAAD, MAPWCA • Professor of Public Health and Medicine • University of Toronto • Toronto, Ontario, Canada • Director • International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care) • Dalla Lana School of Public Health • University of Toronto • Past President • World Union of Wound Healing Societies • Clinical Editor • Advances in Skin & Wound Care • Philadelphia, Pennsylvania.
    Erythroderma is a condition caused by several etiologies that result in red inflamed skin on 90% or more of the body surface. To optimize the diagnosis and management of the erythrodermic patient, healthcare professionals should be familiar with the underlying etiologies and treatment modalities. Patients with erythroderma require immediate attention as they may face a variety of medical complications. Read More

    Adverse cutaneous drug reactions--a clinico-demographic study in a tertiary care teaching hospital of the Kashmir Valley, India.
    Arch Iran Med 2015 Apr;18(4):228-33
    Department of Dermatology, Sher-I-Kashmir Institute of Medical Sciences-Medical College Hospital, Bemina, Srinagar, India.
    Background: Adverse cutaneous drug reactions (ACDRs) are caused by a wide variety of agents. The aim was to study the incidence and clinico-demographic profile of ACDRs to identify any potential risk factors and compare the results with other studies.

    Methods: A cross-sectional observational study was conducted over a period of one year from October 2012 to October 2013 in the outpatient department (OPD) of a tertiary care teaching hospital of the Kashmir valley in India and various ACDRs were recorded. Read More

    Differential expression of TOX by skin-infiltrating T cells in Sézary syndrome and erythrodermic dermatitis.
    J Cutan Pathol 2015 Sep 6;42(9):604-9. Epub 2015 May 6.
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: The histopathologic differentiation between Sézary syndrome (SS) and erythrodermic dermatitis may be extremely difficult. In this immunohistochemical study, it was investigated if thymocyte selection-associated high mobility group box protein (TOX) and C-MYC can be used as additional diagnostic markers to differentiate between SS and erythrodermic dermatitis.

    Method: Paraffin-embedded skin biopsies from 15 SS patients and 17 erythrodermic dermatitis patients were stained and scored for TOX or C-MYC expression. Read More

    Adverse events of anti-tumor necrosis factor α therapy in ankylosing spondylitis.
    PLoS One 2015 12;10(3):e0119897. Epub 2015 Mar 12.
    Department of Rheumatology and Immunology, Changhai Hospital Second Military Medical University, Yangpu District, No.168 Changhai Road, Shanghai-200433, China.
    Objective: This study aims to investigate the prevalence of short-term and long-term adverse events associated with tumor necrosis factor-α (TNF-α) blocker treatment in Chinese Han patients suffering from ankylosing spondylitis (AS).

    Methods: The study included 402 Chinese Han AS patients treated with TNF-α blockers. Baseline data was collected. Read More

    Immunologic Overlap of Helper T-Cell Subtypes 17 and 22 in Erythrodermic Psoriasis and Atopic Dermatitis.
    JAMA Dermatol 2015 Jul;151(7):753-60
    Pathology Service, Dermatopathology Unit, Massachusetts General Hospital and Harvard Medical School, Boston.
    Importance: Psoriasis and atopic dermatitis (AD) are inflammatory diseases thought to be mediated by helper T-cell subtypes 1 and 2 (TH1 and TH2), respectively. Although psoriasis and AD show histopathologic differences during chronic disease, they are difficult to distinguish histologically during erythrodermic exacerbations.

    Objective: To determine whether the immune phenotype of helper T cells can differentiate erythrodermic psoriasis and erythrodermic AD by studying skin biopsy specimens of patients with psoriasis and AD during erythrodermic and chronic disease phases. Read More

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