Therapie 2022 Mar-Apr;77(2):219-227. Epub 2021 Dec 11.
Service de pharmacologie médicale et clinique, CHU de Toulouse, 31000 Toulouse, France; Inserm, UMR1027, université Paul-Sabatier, 31000 Toulouse, France; Service de pharmacologie médicale et clinique, faculté de médecine, université Paul-Sabatier, 31000 Toulouse, France; Centre Midi-Pyrénées de pharmacovigilance, de pharmacoépidémiologie et d'informations sur le médicament, CHU de Toulouse, 31000 Toulouse, France; Inserm CIC 1436 Toulouse, centre d'investigation clinique de toulouse, CHU de Toulouse, 31000 Toulouse, France. Electronic address:
In the 2000s, newer generations of drugs appeared on the market called drugs of targeted therapy (TT) drugs. The introduction of TT in oncology has profoundly changed the prognosis of many cancers but also introduced a wide variety of adverse drugs reactions (ADR), including in particular dermatological adverse drug reactions (DADRs). We investigated the evolutions of the notifications of DADRs of anticancer drugs since 2000s in international pharmacovigilance data. Read More