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    [Frequency of contact sensitization to modern dressings used to treat chronic leg ulcer].
    Ann Dermatol Venereol 2018 Apr 17. Epub 2018 Apr 17.
    Service de dermatologie, CHU, avenue du Général-Koenig, 51100 Reims, France.
    Introduction: Allergic contact dermatitis around chronic leg ulcers (CLU) is a common complication in patients presenting CLU and prolongs healing times. The aim of this study was to describe the rate of sensitization to modern dressings (MD) used in these patients and to assess whether there is a relation between the number of sensitizations and ulcer type, the time from onset of the ulcer, and patient age and gender.

    Patients And Methods: We conducted a retrospective study at Reims University Hospital between 2010 and 2014 that included all patients with CLU of vascular etiology surrounded by eczematous lesions, and who had one of the patch-tests in the following 3 series: European baseline±leg ulcers±corticosteroids. Read More

    Clinical utility of marketing terms used for over-the-counter dermatologic products.
    J Dermatolog Treat 2018 Apr 19:1-20. Epub 2018 Apr 19.
    a Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
    Background: Cosmetic products are commonly marketed using dermatologic terms such as "hypoallergenic," "non-comedogenic," "fragrance-free," etc. The clinical relevance of these claims can be confusing to both patients and clinicians.

    Methods: A systematic review was performed from via a PubMed search of published articles from January 1985 to October 2017 to further describe and elucidate the clinical utility of a predefined list of common dermatologic terms used by pharmaceutical companies to market over the counter products. Read More

    The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice.
    Int Arch Allergy Immunol 2018 Apr 18. Epub 2018 Apr 18.
    Background: Although immunosuppressants for therapy of atopic dermatitis (AD) are still being sought, proteasome inhibitors are also potential candidates for the treatment of AD. Proteasome inhibitors exert various effects by blocking proteasomal degradation and help regulate processes such as apoptosis induction via caspase-9, cell cycle progression via cyclins, NF-κB inactivation via IκB, and downregulation of antigen cross-presentation. The cells targeted by proteasome inhibitors are therefore activated cells undergoing proliferation or differentiation, and antigen-presenting cells carrying out protein degradation. Read More

    Coral Dermatitis or Infectious Dermatitis: Report of a Case of Staphylococcus Aureus Infection of Skin After Scuba Diving.
    Cureus 2018 Feb 16;10(2):e2196. Epub 2018 Feb 16.
    Department of Microbiology, Prathima Institute of Medical Sciences.
    Skin lesion which develops after deep sea diving is termed as coral dermatitis. The corals are known to produce a toxic substance which when comes in to contact with human skin may elicit hypersensitive reactions. Most previous reports highlight the allergic reactions caused by deep sea diving. Read More

    Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014.
    J Am Acad Dermatol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Dermatology, University of Cincinnati, Cincinnati, Ohio.
    Background: Nickel is a common allergen responsible for allergic contact dermatitis.

    Objective: To characterize nickel sensitivity in children and compare pediatric cohorts (≤5, 6-12, and 13-18 years).

    Methods: Retrospective, cross-sectional analysis of 1894 pediatric patients patch tested by the North American Contact Dermatitis Group from 1994 to 2014. Read More

    Evaluation of Eluxadoline Effect on Cardiac Repolarization.
    Clin Pharmacol Drug Dev 2018 Apr 16. Epub 2018 Apr 16.
    Former employee of Furiex Pharmaceuticals, Inc., an affiliate of Allergan plc, Madison, NJ, USA.
    This study evaluated the effects of eluxadoline, a mixed μ-opioid receptor (OR) and κ-OR agonist and δ-OR antagonist, on cardiac repolarization. This evaluator-blinded, placebo- and positive-controlled, 4-period crossover study randomized healthy men and women to single oral doses of eluxadoline (therapeutic dose 100 mg or supratherapeutic dose 1000 mg), moxifloxacin 400 mg, or placebo. QT data were corrected using individual custom correction (QTcI). Read More

    Absence of human skin irritation and allergenic potential after repeated patch applications of a lamellar moisturizer.
    J Cosmet Dermatol 2018 Apr 15. Epub 2018 Apr 15.
    GSK Consumer Healthcare, St George's Avenue, Weybridge, Surrey, UK.
    Background: New cosmetic products should undergo clinical evaluation for skin sensitization potential.

    Objectives: To assess the irritation and sensitization potential of a moisturizer containing lamellar structured lipids after repeated patch application in humans, using human repeated insult patch test methodology.

    Methods: This 6-week, single-center, open-label study compared a lamellar moisturizer with negative saline control in human subjects aged 18-70 years and skin phototype (Fitzpatrick) classification I-IV. Read More

    Photoallergic Contact Dermatitis to Sunscreens Containing Oxybenzone in La Plata, Argentina.
    Actas Dermosifiliogr 2018 Apr 11. Epub 2018 Apr 11.
    Chemotechnique Diagnostics, Vellinge, Suecia.
    Background: Photoallergic contact dermatitis (PACD) to oxybenzone was reported for the first time in 1980. Oxybenzone is the most common photoallergen in the United States and Canada and the fourth most common .in Europe. Read More

    S1 Guidelines - Dermatoses associated with dermal lymphostasis.
    J Dtsch Dermatol Ges 2018 Apr;16(4):512-523
    Former Department of Dermatology, Allergology, Phlebology, and Lymphology, Sanaderm Hospital, Bad Mergentheim, Germany.
    The objective of the present S1 guidelines is to present current knowledge about dermatologically relevant diseases associated with localized dermal lymphostasis, thus facilitating their early detection, diagnostic workup, and targeted treatment. Whenever possible, treatment should be based on stage-appropriate and clearly defined algorithms. The numerous issues regarding differential diagnosis and treatment clinicians are confronted with in everyday clinical practice seem to warrant the publication of up-to-date guidelines. Read More

    Multispectral Dermatoscopic Features of Chemical Leucoderma with Pigmented Contact Dermatitis.
    Indian Dermatol Online J 2018 Mar-Apr;9(2):107-109
    Department of General Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
    Chemical leukoderma is characterized by pigment loss on constant exposure to chemical agents. Its association with pigmented contact dermatitis is rare. Here, we report a 40-year-old female presenting with depigmented macule with surrounding hyperpigmentation over the upper forehead. Read More

    Evaluation of nickel and cobalt release from mobile phone devices used in Brazil.
    An Bras Dermatol 2018 Jan-Feb;93(1):151-153
    Dermatology clinic at Santa Casa de São Paulo - São Paulo (SP), Brazil.
    Nickel and cobalt are often responsible for metal-induced allergic contact dermatitis. With the increasing use of cell phones, we observed an increase in cases reports on telephone-related allergic contact dermatitis. The present study evaluated nickel and cobalt release from mobile phones used in Brazil. Read More

    Nickel, chromium and cobalt: the relevant allergens in allergic contact dermatitis. Comparative study between two periods: 1995-2002 and 2003-2015.
    An Bras Dermatol 2018 Jan-Feb;93(1):59-62
    Dermatology Clinic, Santa Casa de São Paulo - São Paulo (SP), Brazil.
    Background: Metals are common agents of allergic contact dermatitis, occupational or not, with decreasing incidence over the last years in some countries that have regulated the amount of nickel in objects.

    Objectives: To analyze and compare with previous studies the profile of metal sensitization between 2003-2015.

    Methods: Patients who underwent patch testing between 2003-2015 were evaluated retrospectively regarding the sensitization rates to metals, the associations between them, the relationship with profession and epidemiology. Read More

    Allergic contact dermatitis caused by isobornyl acrylate in OmniPod, an innovative tubeless insulin pump.
    Contact Dermatitis 2018 Apr 10. Epub 2018 Apr 10.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
    Background: The frequency of allergic contact dermatitis caused by (meth)acrylates is increasing worldwide, and isobornyl acrylate (IBOA) has been identified as a culprit sensitizer in FreeStyle Libre, a medical device used by diabetic patients.

    Objectives: To report on 4 patients sensitized to IBOA contained in OmniPod, a new, tubeless insulin pump, and to describe the clinical and chemical analytical work-up.

    Method: Four patients with eczematous skin eruptions after using OmniPod, including 2 with previous adverse skin reactions to FreeStyle Libre, were patch tested with a baseline series and additional (meth)acrylates, including IBOA in several concentrations and/or vehicles. Read More

    Prevalence of contact allergy to metals in the European general population with a focus on nickel sulfate and piercings: The EDEN Fragrance Study.
    Contact Dermatitis 2018 Apr 10. Epub 2018 Apr 10.
    Department of Social Medicine, Occupational and Environmental Dermatology, University Heidelberg, Heidelberg, Germany.
    Background: Studies on sensitization to metals in the general population are scarce.

    Objectives: To determine the prevalence of sensitization to metals in the general population, and factors associated with nickel sensitization.

    Methods: In 5 European countries (The Netherlands, Germany, Italy, Portugal and Sweden), a random sample (N = 3119) from the general population (aged 18-74 years) was patch tested and interviewed by use of a questionnaire on exposure to metals, piercing, and jewellery. Read More

    Activation of T cells by dendritic cells exposed to a reference sensitizer: Towards a promising model to assess the allergenic potential of chemicals.
    Contact Dermatitis 2018 Apr 10. Epub 2018 Apr 10.
    Department of Toxicology and Biometrology, National Institute for Research and Safety (INRS), Vandœuvre-lès-Nancy cedex, France.
    Background: Low molecular weight chemicals constitute one of the major causes of occupational allergies. European legislation on chemicals recommends limiting the use of in vivo models for assessing the sensitizing potential of chemicals, and encourages the development of integrated alternative methods. An in vitro mouse model of bone marrow-derived dendritic cells (BMDCs) that showed good accuracy (75%) and sensitivity (69%) has previously been developed to assess the sensitizing potential of chemicals. Read More

    Anti-inflammatory properties of cannabidiol, a non-psychotropic cannabinoid, in experimental allergic contact dermatitis.
    J Pharmacol Exp Ther 2018 Apr 9. Epub 2018 Apr 9.
    CNR;
    Phytocannabinoids modulate inflammatory responses by regulating the production of cytokines in several experimental models of inflammation. Cannabinoid type-2 (CB2) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). We investigated if non-psychotropic cannabinoids like cannabidiol (CBD) produced similar effects in this experimental model of ACD. Read More

    Phytophotodermatitis induced by wild parsnip.
    Dermatol Online J 2018 Feb 15;24(2). Epub 2018 Feb 15.
    Town Square Dermatology, Coralville, Iowa.
    Phytophotodermatitis results when skin is exposed to ultraviolet light after previous contact with a phototoxic compound. Wild parsnip (Pastinia sativa), a member of the Umbelliferae family, is an invasive plant species introduced to North America as a root vegetable. Although cultivated less commonly today, the plant is increasingly found growing wild in prairies and roadsides. Read More

    Assessment of dermal uptake of diphenylmethane-4,4'-diisocyanate using tape stripping and biological monitoring.
    Eur J Dermatol 2018 Apr 5. Epub 2018 Apr 5.
    Lund University, Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö, Sweden.
    Very little is known about the dermal uptake of isocyanates, and dermal exposure to isocyanates has been discussed as a factor involved in the induction of respiratory diseases. To investigate the dermal uptake of diphenylmethane-4,4'-diisocyanate (4,4'-MDI). Four volunteers were dermally exposed to 10, 25, 49 and 50 mg 4,4'-MDI, respectively, for eight hours. Read More

    A Review of the Medical Necessity of Comprehensive Patch Testing.
    Dermatitis 2018 Apr 2. Epub 2018 Apr 2.
    Allergic contact dermatitis is associated with significant disease and economic burden in the United States. To properly manage allergic contact dermatitis, it is important to accurately identify the substance(s) implicated in the dermatitis to prevent disease recurrence. The commercially available T. Read More

    Case Report: Paederus Dermatitis in the Returning Traveler.
    Am J Trop Med Hyg 2018 Apr 2. Epub 2018 Apr 2.
    Division of Infectious Disease, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia.
    Rash in the returned traveler can provide a diagnostic dilemma for clinicians, but a detailed history including epidemiologic exposures can allow prompt diagnosis of etiologies uncommon in the United States. One such disease is Paederus dermatitis, an irritant contact dermatitis related to exposure to the rove beetle characterized by bullous lesions with surrounding erythema. Although cases and outbreaks have commonly been reported throughout the world, they are rarely reported in travelers returning to the United States. Read More

    Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood.
    JAMA Pediatr 2018 Apr 2:e180315. Epub 2018 Apr 2.
    Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
    Importance: Allergic diseases are prevalent in childhood. Early exposure to medications that can alter the microbiome, including acid-suppressive medications and antibiotics, may influence the likelihood of allergy.

    Objective: To determine whether there is an association between the use of acid-suppressive medications or antibiotics in the first 6 months of infancy and development of allergic diseases in early childhood. Read More

    Anti-inflammatory potency testing of topical corticosteroids and calcineurin inhibitors in human volunteers sensitized to diphenylcyclopropenone.
    Br J Clin Pharmacol 2018 Apr 1. Epub 2018 Apr 1.
    Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, 5000, Odense C, Denmark.
    Aim: To quantify the anti-inflammatory potency of topical corticosteroids and topical calcineurin inhibitors by measuring the contact allergic response to a diphenylcyclopropenone (DPCP) challenge in de novo sensitized human volunteers.

    Methods: Two randomized, double-blind, vehicle-controlled studies were performed encompassing 76 volunteers; 29 in the first and 47 in the second studies. Topical drugs were applied pre- and/or post-treatment in block designs. Read More

    Presenteeism in a Dutch hand eczema population-a cross-sectional survey.
    Contact Dermatitis 2018 Apr 1. Epub 2018 Apr 1.
    Department of Dermatology, University of Groningen, University Medical Centre, Groningen, The Netherlands.
    Background: Presenteeism (attending work despite complaints and ill health, which should prompt rest and absence) has been overlooked in the field of hand eczema.

    Objectives: To examine the 1-year prevalence of presenteeism related to hand eczema in a population of hand eczema patients who visited a tertiary referral centre. Secondary objectives: to identify intrinsic/extrinsic reasons for presenteeism and to evaluate associated factors. Read More

    Specific barrier response profiles after experimentally induced skin irritation in vivo.
    Contact Dermatitis 2018 Apr 2. Epub 2018 Apr 2.
    Department of Dermatology, University of Lübeck, Lübeck, Germany.
    Background: Recently, natural moisturizing factors (NMFs) and corneocyte surface topography were suggested as biomarkers for irritant dermatitis.

    Objectives: To investigate how exposure to different irritants influences corneocyte surface topography, NMF levels and the barrier function of human skin in vivo.

    Methods: Eight healthy adult volunteers were exposed to aqueous solutions of 60% n-propanol, 0. Read More

    Can the epoxides of cinnamyl alcohol and cinnamal show new cases of contact allergy?
    Contact Dermatitis 2018 Mar 30. Epub 2018 Mar 30.
    Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden.
    Background: Cinnamyl alcohol is considered to be a prohapten and prehapten with cinnamal as the main metabolite. However, many individuals who are allergic to cinnamyl alcohol do not react to cinnamal. Sensitizing epoxides of cinnamyl alcohol and cinnamal have been identified as metabolites and autoxidation products of cinnamyl alcohol. Read More

    An unusual presentation of a common condition: Allergic contact dermatitis.
    Int Wound J 2018 Mar 30. Epub 2018 Mar 30.
    Wound Healing Research Unit, Cardiff University, Cardiff, UK.
    Allergic contact dermatitis commonly affects patients with chronic venous leg ulcers and can contribute to impaired wound healing. Many allergens have been identified, and despite the use of advanced dressings, the incidence of allergy has remained high. We discuss an unusual presentation of allergic contact dermatitis in a patient with a chronic wound. Read More

    Contact sensitivity in patients with venous leg ulcer: A multi-centric Indian study.
    Int Wound J 2018 Mar 30. Epub 2018 Mar 30.
    Department of Dermatology, Venereology & Leprology, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
    Venous leg ulcers are the most common form of non-healing leg ulcers. They are subjected to treatments such as topical medications, dressings, and compression therapies. This can lead to exposure to a number of allergens with subsequent sensitisation and contact dermatitis of the regional skin. Read More

    Differential diagnoses of diaper dermatitis.
    Pediatr Dermatol 2018 Mar;35 Suppl 1:s10-s18
    Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Keil, Germany.
    Diaper dermatitis is the most common contact eczema present in early childhood. The main cause is an irritant reaction to urine and feces, which is facilitated by the occlusive conditions under the diaper, leading to hyperhydration of the stratum corneum (diaper dermatitis). In addition, diaper pressure and friction can increase the risk of skin inflammation, which also opens the skin up to other irritant agents, allergens, and infectious agents, such as candida albicans. Read More

    Occupational Contact Dermatitis in the Canadian Aircraft Industry: A 25-Year Retrospective Study.
    Dermatitis 2018 Mar 24. Epub 2018 Mar 24.
    From the Division of Dermatology, Department of Medicine, McGill University Health Centre, Montreal General Hospital, Québec, Canada.
    Background: Aircraft building exposes workers to irritant and sensitizing products.

    Objective: The aim of this article was to study occupational dermatoses among aircraft workers over 25 years.

    Methods: The files of aerospace workers referred between 1990 and 2015 were extracted from the database of the McGill University Health Centre contact dermatitis clinic. Read More

    Both children and adult patients with difficult-to-treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized.
    J Eur Acad Dermatol Venereol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Dermatology of the Academic Medical Center, Amsterdam, The Netherlands.
    Background: Concomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult-to-treat. However, contact sensitization in this patient group has barely been studied.

    Objective: To study the occurrence of ACD in a population of difficult-to-treat AD children and adults. Read More

    Delayed-type allergy to cobalt-comparison of a flow cytometric lymphocyte proliferation test with patch testing.
    Contact Dermatitis 2018 Mar 26. Epub 2018 Mar 26.
    Department of Dermatology, Allergy Unit, University Hospital Basel and University of Basel, Basel, Switzerland.
    Background: The patch test is the standard procedure for diagnosing delayed-type sensitization. If a patch test is not possible, the flow cytometric lymphocyte proliferation test (LPT), which determines the number and type of cells responding to a specific antigen in vitro, might be considered as an alternative.

    Objectives: Our aim was to establish a flow cytometric LPT for the detection of delayed-type allergic responses to cobalt, and to determine the correlation between stimulation indices (SIs) in LPT and the grade of patch test reactions. Read More

    Mrgprs activation is required for chronic itch conditions in mice.
    Itch (Phila) 2017 Dec;2(3)
    School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
    Introduction: Chronic itch has been drawing much attention due to its clinical significance and the complexity of its mechanisms. To facilitate the development of anti-itch strategies, it is necessary to investigate the key players in itch sensation under chronic itch conditions. Several members of the Mrgpr family were identified as itch receptors that detect cutaneous pruritogens in primary sensory neurons. Read More

    Adverse events reported to the Food and Drug Administration from 2004 to 2016 for cosmetics and personal care products marketed to newborns and infants.
    Pediatr Dermatol 2018 Mar;35(2):225-229
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
    Background/objectives: Despite their ubiquitous use and several recent health controversies involving cosmetics and personal care products for children, the Food and Drug Administration has little oversight of these products and relies on consumer-submitted adverse event reports. We assessed the recently released Center for Food Safety and Applied Nutrition's Adverse Event Reporting System database for adverse event reports submitted to the Food and Drug Administration for baby personal care products and to determine whether useful insights can be derived.

    Methods: We extracted the Center for Food Safety and Applied Nutrition's Adverse Event Reporting System data file from 2004 to 2016 and examined the subset classified according to the Food and Drug Administration-designated product class as a baby product. Read More

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