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    1 OF 725

    Evaluation of the GARD assay in a blind Cosmetics Europe study.
    ALTEX 2017 Feb 17. Epub 2017 Feb 17.
    Dept. of Immunotechnology, Lund University, Lund, Sweden.
    Chemical hypersensitivity is an immunological response towards foreign substances, commonly referred to as sensitizers, which gives rise primarily to the clinical symptoms known as allergic contact dermatitis. For the purpose of mitigating risks associated with consumer products, chemicals are screened for sensitizing effects. Historically, such predictive screenings have been performed using animal models. Read More

    Allergic contact cheilitis from anethole-containing toothpastes: a practical solution.
    J Eur Acad Dermatol Venereol 2017 Feb 18. Epub 2017 Feb 18.
    Contact Allergy Unit, Department of Dermatology, University Hospital Antwerp, Wilrijkstraat 10, 2650, Antwerp, Belgium.
    In patients presenting with therapy-resistant cheilitis, especially when extending to the perioral skin, patch tests should be performed, even in longstanding cases(1-2) . A 55-year-old woman suffered from an oozing cheilitis for three months with erythema, edema and crusting of the lips and perioral skin (Fig. 1). Read More

    Occupational contact dermatitis from protein in sea products: who is the most affected, the fisherman or the chef?
    J Occup Med Toxicol 2017 10;12. Epub 2017 Feb 10.
    Service de dermato-vénéréologie CHRU Morvan, 2 avenue FOCH, Brest Cedex, 29609 France ; Société Française de Médecine Maritime, 22, Avenue Camille Desmoulins, Brest, 29200 France.
    Background: Protein contact dermatitis has frequently been reported in case studies (usually in cases involving contact with seafood products), but there are very few descriptive series. The objectives of this present study were firstly to determine the incidence of protein contact dermatitis among fishermen in France and compare it with data from onshore work involving seafood exposure. Second, to discover what factors could explain any differences. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Allergenic sesquiterpene lactones from cushion bush (Leucophyta brownii Cass.): new and old sensitizers in a shrub-turned-a-pot plant.
    Contact Dermatitis 2017 Feb 14. Epub 2017 Feb 14.
    Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, 5230 Odense M, Denmark.
    Background: The Australian cushion bush (Leucophyta brownii) of the Compositae family of plants has become a popular pot and container plant. The plant produces the sesquiterpene lactone allergen calocephalin.

    Objectives: To assess the sensitizing potential of sesquiterpene lactones from cushion bush. Read More

    The current spectrum of contact sensitization in patients with chronic leg ulcers or stasis dermatitis - new data from the Information Network of Departments of Dermatology (IVDK).
    Contact Dermatitis 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, University Hospital Erlangen, 91054, Erlangen, Germany.
    Background: Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization.

    Objectives: To identify the current spectrum of contact allergens in these patients.

    Patients And Methods: Data of the Information Network of Departments of Dermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n = 55 510). Read More

    Evaluation of lymphocyte transformation tests as compared with patch tests in nickel allergy diagnosis.
    Contact Dermatitis 2017 Feb 7. Epub 2017 Feb 7.
    Department of Dermatology and Allergology, Ludwig-Maximilians-University, 80337, Munich, Germany.
    Background: The patch test is considered to be the gold standard for diagnosing nickel (Ni) allergy. The lymphocyte transformation test (LTT) can also be used to detect Ni sensitization. However, little is known about the correlation between patch test and LTT reactions to Ni. Read More

    Contact allergy caused by isothiazolinone derivatives: an overview of non-cosmetic and unusual cosmetic sources.
    Eur J Dermatol 2017 Feb 3. Epub 2017 Feb 3.
    Dermatochemistry laboratory, Institute of Chemistry, University of Strasbourg, Strasbourg, France.
    The isothiazolinone derivatives, methylchloroisothiazolinone (MCI), methylisothiazolinone (MI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT), owing to their strong bactericide, fungicide and algicide properties, are widely used in non-cosmetic products, such as chemical (industrial) products, household detergents, and water-based paints, and the former two derivatives are also used in cosmetic products. However, given their inherent sensitization potential (with MCI > MI > BIT > OIT), allergic contact dermatitis is frequently observed, both in consumers as well as workers in various industries. In this review, we provide an update on the use of MCI/MI and MI in cosmetics, highlighting certain aspects of MI; the use of excessive concentrations, the presence in some less familiar cosmetic products, and the association with unusual clinical manifestations. Read More

    Gallate Contact Dermatitis: Systematic Review and Product Update.
    Dermatitis 2017 Feb 6. Epub 2017 Feb 6.
    From the *Duke University School of Medicine, Duke University; †Duke University Medical Center Library; and ‡Department of Dermatology, Duke University Medical Center, Durham, NC.
    Allergic contact dermatitis related to cosmetic use can result from allergens not routinely evaluated by standard patch test protocols. Propyl, octyl, and dodecyl gallates are commonly used as antioxidant preservatives with reports of associated allergic contact dermatitis in the literature. The objectives of this review were to investigate the role of gallates in allergic contact dermatitis and to explore products containing these preservatives. Read More

    American Contact Dermatitis Society Core Allergen Series: 2017 Update.
    Dermatitis 2017 Feb 6. Epub 2017 Feb 6.
    From the *Geisel School of Medicine at Dartmouth, Hanover, NH; †University of Colorado Denver and the Denver VA Medical Center; ‡University Hospitals Cleveland Medical Center, OH; §University of Pennsylvania, Philadelphia; ∥University of Minnesota, Minneapolis; and ¶Geisinger Health System, Danville, PA.
    The American Contact Dermatitis Society Core Allergen Series was introduced in 2012. After 4 years of use, changes in our recommended allergens are necessary. For the updated series, we have reordered the first 4 panels to approximately mirror the current TRUE Test and removed parthenolide, triclosan, glutaraldehyde, and jasmine. Read More

    Utility of Store and Forward Teledermatology for Skin Patch Test Readings.
    Dermatitis 2017 Feb 6. Epub 2017 Feb 6.
    From the *University of Minnesota Medical School; †HCMC Parkside Occupational and Contact Dermatitis Clinic; ‡Department of Dermatology, Minneapolis Veterans Affairs Medical Center; and §Department of Dermatology, University of Minnesota Medical School, Minneapolis.
    Background: Teledermatology (TD) is the use of imaging technology to provide dermatology services at a distance. To date, studies assessing its application for grading skin patch test reactions have been lacking.

    Objectives: The aim was to compare conventional, in-person (IP) grading of skin patch test reactions with store-forward TD. Read More

    Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use.
    Int Arch Occup Environ Health 2017 Feb 6. Epub 2017 Feb 6.
    Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Kildegårdsvej 28, 2900, Hellerup, Denmark.
    Purpose: The aim of the study is to investigate risk factors for sensitization to preservatives and to examine to which extent different preservatives are registered in chemical products for occupational use in Denmark.

    Methods: A retrospective epidemiological observational analysis of data from a university hospital was conducted. All patients had occupational contact dermatitis and were consecutively patch tested with 11 preservatives from the European baseline series and extended patch test series during a 5-year period: 2009-2013. Read More

    Tetradecanol reduces EL-4 T cell growth by the down regulation of NF-κB mediated IL-2 secretion.
    Eur J Pharmacol 2017 Feb 3. Epub 2017 Feb 3.
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea. Electronic address:
    Tetradecanol is a straight-chain saturated fatty alcohol purified from Dendropanax morbifera leaves. We found that tetradecanol (30μM) reduced specifically the growth of T cells such as EL-4 T cell and isolated murine CD4(+) T cells. In this study, we investigated the effects of tetradecanol on the regulation of interlukin-2 (IL-2), a potent T cell growth factor. Read More

    Dermatoses among automobile mechanics in Mansoura, Egypt.
    Arch Environ Occup Health 2017 Feb 3. Epub 2017 Feb 3.
    c MD of Dermatology, Andrology and STDs, Department of Dermatology , Andrology and STDs, Faculty of Medicine, Mansoura University , Mansoura , Egypt .
    This cross-sectional study was carried out in Mansoura city, Egypt to assess the prevalence of occupational dermatoses and their possible risk factors on a convenience sample of car mechanics. Socio-demographic and occupational data were collected, and clinical examination was done. Prevalence of skin diseases was 45. Read More

    Contact Dermatitis Due to Nickel Allergy in Patients Suffering from Non-Celiac Wheat Sensitivity.
    Nutrients 2017 Feb 2;9(2). Epub 2017 Feb 2.
    Dipartimento di Biologia e Medicina Interna e Specialistica (DiBiMIS), Internal Medicine Unit, University Hospital, Palermo 90100, Italy.
    Background:  Non-celiac wheat sensitivity (NCWS) is a new clinical entity in the world of  gluten-related diseases. Nickel, the most frequent cause of contact allergy, can be found in wheat  and results in systemic nickel allergy syndrome and mimics irritable bowel syndrome (IBS).  Objective: To evaluate the frequency of contact dermatitis due to nickel allergy in NCWS patients  diagnosed by a double-blind placebo-controlled(DBPC)challenge,and to identify  the  characteristics  of  NCWS  patients  with  nickel  allergy. Read More

    Occupational skin diseases from 1997 to 2004 at the Department of Dermatology, University Hospital of Northern Norway (UNN): an investigation into the course and treatment of occupational skin disease 10-15 years after first consultations with a dermatologist.
    Int J Circumpolar Health 2016 Jan;75(1):30100
    b University of Tromsø , Northern Norway , Tromsø , Norway.
    Objectives We investigate the impact of occupational skin disease consultations among outpatients at the Dermatological Department, University Hospital, Northern Norway. Study design From 1997 until 2004, 386 patients with occupational skin disease were examined and given advice on skin care, skin disease treatment, skin protection in further work, and on the legal rights of patients with this disease. Ten to fifteen years later, we wanted to look at these patients in terms of their work situation, the current status of their disease, the help they received from the labour offices, and their subjective quality of life. Read More

    Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus.
    Parasit Vectors 2017 Jan 31;10(1):51. Epub 2017 Jan 31.
    Departament of Biochemistry and Immunology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, SP, 14049-900, Brazil.
    Background: Ticks attach to and penetrate their hosts' skin and inactivate multiple components of host responses in order to acquire a blood meal. Infestation loads with the cattle tick, Rhipicephalus microplus, are heritable: some breeds carry high loads of reproductively successful ticks, whereas in others, few ticks feed and reproduce efficiently.

    Methods: In order to elucidate the mechanisms that result in the different outcomes of infestations with cattle ticks, we examined global gene expression and inflammation induced by tick bites in skins from one resistant and one susceptible breed of cattle that underwent primary infestations with larvae and nymphs of R. Read More

    Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression.
    BMC Complement Altern Med 2017 Jan 31;17(1):81. Epub 2017 Jan 31.
    Environnement and Health team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Safi, Morocco.
    Background: Several chronic inflammatory diseases are characterized by inappropriate CD4+ T cell response. In the present study, we assessed the ability of Capparis spinosa L. (CS) preparation to orientate, in vivo, the immune response mediated by CD4+ T cells towards an anti-inflammatory response. Read More

    Emission characteristics of allergenic terpenols in PM2.5 released from incense burning and the effect of light on the emissions.
    Sci Total Environ 2017 Jan 25. Epub 2017 Jan 25.
    Department of Environmental Engineering and Science, Chia Nan University of Pharmacy and Science, 60, Sec. 1, Erren Rd., Rende Dist., Tainan City 71710, Taiwan; Indoor Air Quality Research and Service Center, Chia Nan University of Pharmacy and Science, 60, Sec. 1, Erren Rd., Rende Dist., Tainan City 71710, Taiwan. Electronic address:
    This study investigated allergenic terpenol compounds in incense powder and smoke. The powder of two Thai brands contained higher concentrations of terpenols up to 6.15 times higher than those of two Taiwanese brands. Read More

    Vesicular Contact Reaction May Progress into Erythema Multiforme.
    Acta Dermatovenerol Croat 2016 Dec;24(4):307-309
    Prof. Magdalena Czarnecka-Operacz, MD, PhD, Department of Dermatology, 49 Przybyszewski Str., 60-355 Poznań, Poland.
    Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. Read More

    Structure-Potency Relationships for Epoxides in Allergic Contact Dermatitis.
    Chem Res Toxicol 2017 Feb 25;30(2):524-531. Epub 2017 Jan 25.
    Research Institute for Fragrance Materials, Inc. , 50 Tice Boulevard, Woodcliff Lake, New Jersey 07677, United States.
    Epoxides are known or proposed to be involved in skin sensitization in various ways. Some are encountered directly, and others have been shown to be formed abiotically and metabolically from various unsaturated chemicals. They can react as SN2 electrophiles. Read More

    Detection of local inflammation induced by repeated exposure to contact allergens by use of IVIS SpectrumCT analyses.
    Contact Dermatitis 2017 Jan 25. Epub 2017 Jan 25.
    Department of Immunology and Microbiology, University of Copenhagen, 2200, Copenhagen, Denmark.
    Background: Contact allergy is characterized by local skin inflammation that, in some cases, can result in systemic immune activation.

    Objectives: To investigate whether IVIS SpectrumCT analyses can be used to detect the immune response induced by contact allergens.

    Methods: Mice were repeatedly exposed to vehicle or allergens on the ears. Read More

    Experimental patch testing with chromium-coated materials.
    Contact Dermatitis 2017 Jan 25. Epub 2017 Jan 25.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Background: Chromium coatings on metal alloys can be decorative, and prevent corrosion and metal ion release. We recently showed that handling of a chromium-containing disc resulted in chromium deposition on the skin.

    Objectives: To examine patch test reactivity to chromium-coated discs. Read More

    Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions.
    Br J Dermatol 2017 Jan 24. Epub 2017 Jan 24.
    Department of Medical Sciences, Dermatology and Venereology, Uppsala University, Uppsala, Sweden.
    Background: Skin mast cells are implicated as detrimental effector cells in various inflammatory skin diseases such as contact eczema, atopic dermatitis and psoriasis. Selective reduction of cutaneous mast cells, e.g. Read More

    Appropriate Testing of Isothiazolinones in Children.
    Pediatr Dermatol 2017 Jan 23. Epub 2017 Jan 23.
    Department of Dermatology, Loma Linda University, Loma Linda, California.
    Background/objective: The isothiazolinones methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are prevalent pediatric contact sensitizers. MI allergic contact dermatitis (ACD) is underreported in the literature. The objective of the current study was to use a database of provider-reported U. Read More

    Chromium(VI) Contact Dermatitis: Getting Closer to Understanding the Underlying Mechanisms of Toxicity and Sensitization!
    J Invest Dermatol 2017 Feb;137(2):274-277
    Department of Dermatology and Allergology, Technical University of Munich, Munich, Germany.
    Various haptens trigger innate immune pathways and/or induce cytotoxicity as a part of sensitization. Adam et al. decipher in vitro the mechanisms by which chromium(VI) induces inflammation, the likely prerequisites for toxicity, sensitization, and allergic contact dermatitis against chromium(VI). Read More

    High-concentration topical capsaicin may abolish the clinical manifestations of allergic contact dermatitis by effects on induction and elicitation.
    Med Hypotheses 2017 Feb 27;99:53-56. Epub 2016 Dec 27.
    Laboratory of Experimental Cutaneous Pain Research, SMI®, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark. Electronic address:
    Allergic contact dermatitis (ACD) is a common skin condition caused by a type-IV hypersensitivity reaction. Even though ACD is considered as a T-cell mediated disease, indications exists that peptidergic nerve fibers at the site of allergen exposure and associated with the draining lymph node play a prominent role in both induction and elicitation of ACD. This neuro-immune cross talk seems rely on neuropeptides such as Substance P secreted by nerve fiber terminals. Read More

    Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway.
    Int J Mol Sci 2017 Jan 18;18(1). Epub 2017 Jan 18.
    Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
    Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. Read More

    Efficacy of a Film-Forming Medical Device Containing Piroxicam and Sun Filters in the Treatment of Multiple Actinic Keratosis Lesions in a Subject with a History of Kaposi Sarcoma.
    Case Rep Dermatol 2016 Sep-Dec;8(3):254-261. Epub 2016 Oct 4.
    Medical Department, Difa Cooper, IFC Group, Caronno Pertusella, Italy.
    Actinic keratosis (AK) is considered a premalignant form of skin cancer due to chronic sun exposure. In addition, human papilloma virus (HPV) has been advocated a role in the pathogenesis of this clinical condition. HPV proteins (mainly E6 and E7) seem to act synergistically with ultraviolet (UV) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after UV damage. Read More

    Epidemiological analysis of occupational dermatitis notified in Brazil in the period 2007 to 2012.
    An Bras Dermatol 2016 Nov-Dec;91(6):732-736
    Universidade Positivo - Curitiba (PR), Brazil.
    Background:: Occupational dermatitis affects the quality of life and productivity of workers. Studies on the subject are scarce in Brazil. It is estimated that the disease is underreported and that many affected patients do not seek health care. Read More

    Prevalence of Preservatives Across All Product Types in the Contact Allergen Management Program.
    Dermatitis 2017 Jan/Feb;28(1):81-87
    From the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison.
    Background: Preservatives are known causes of allergic contact dermatitis.

    Objective: The aim of this study was to determine the prevalence of preservatives in each product category in the Contact Allergen Management Program and compare prevalence with reported rates of allergic contact dermatitis.

    Methods: Contact Allergen Management Program product information was queried based on the 53 approved preservatives for cosmetic products by the European Union and Association of Southeast Asian Nations plus 5 additional preservatives used in US products. Read More

    The Endocannabinoid System and Its Role in Eczematous Dermatoses.
    Dermatitis 2017 Jan/Feb;28(1):22-32
    From the *Drexel University College of Medicine, Philadelphia, PA; †School of Medicine, ‡Department of Dermatology, University of California, Davis; and §Dermatology Division, Department of Medicine, University of Arizona, Tucson.
    The skin serves as the foremost barrier between the internal body and the external world, providing crucial protection against pathogens and chemical, mechanical, and ultraviolet damages. The skin is a central player in the intricate network of immune, neurologic, and endocrine systems. The endocannabinoid system (ECS) includes an extensive network of bioactive lipid mediators and their receptors, functions to modulate appetite, pain, mood, and memory, and has recently been implicated in skin homeostasis. Read More

    Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils.
    Proc Natl Acad Sci U S A 2017 Jan 17;114(5):1111-1116. Epub 2017 Jan 17.
    Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan
    Th2 immunity plays important roles in both protective and allergic responses. Nevertheless, the nature of antigen-presenting cells responsible for Th2 cell differentiation remains ill-defined compared with the nature of the cells responsible for Th1 and Th17 cell differentiation. Basophils have attracted attention as a producer of Th2-inducing cytokine IL-4, whereas their MHC class II (MHC-II) expression and function as antigen-presenting cells are matters of considerable controversy. Read More

    Managing Occupational Irritant Contact Dermatitis Using a Two-Step Skincare Regimen Designed to Prevent Skin Damage and Support Skin Recovery.
    J Drugs Dermatol 2016 Dec;15(12):1504-1510
    Occupational irritant contact dermatitis (ICD) affecting the hands is a common and difficult-to-manage condition. Occupations that necessitate contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing elevate the risk of ICD. Management strategies that do not adequately prevent accumulated damage and repair skin, can develop into chronic dermatoses which negatively impact work productivity and quality of life. Read More

    Efficacy of a Hand Regimen in Skin Barrier Protection in Individuals With Occupational Irritant Contact Dermatitis.
    J Drugs Dermatol 2016 Nov;15(11):s81-s85
    Background: Occupational irritant contact dermatitis (OICD) is a dif cult and hard to manage condition. It occurs more frequently in certain occupations where contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing heightens the risk. Treatment for OICD includes patient education in addition to physical, topical, and systemic therapies. Read More

    Reaction Chemistry to Characterize the Molecular Initiating Event in Skin Sensitization: A Journey to Be Continued.
    Chem Res Toxicol 2017 Jan 30;30(1):315-331. Epub 2016 Nov 30.
    Biosciences, Givaudan Schweiz AG , Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland.
    The publication by the OECD of the adverse outcome pathway (AOP) for skin sensitization has accelerated the development and validation of mechanistic tests and testing strategies to assess the potential of new molecules to trigger skin allergies. The molecular initiating event (MIE) in the AOP is reaction with skin peptides/proteins. It is followed by a number of cellular events. Read More

    Incidence of skin and respiratory diseases among Danish hairdressing apprentices.
    Contact Dermatitis 2017 Jan 16. Epub 2017 Jan 16.
    Department of Dermatology and Allergy, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900, Hellerup, Denmark.
    Background: Hairdressing is one of the professions with the highest risk of occupational skin and respiratory diseases. The incidence of these diseases in hairdressing apprentices has been studied only sparsely.

    Objective: To determine the incidence of skin and respiratory diseases in hairdressing apprentices, and to explore whether hairdressing apprentices leave the trade during training because of these diseases. Read More

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