41,468 results match your criteria Dermatitis Contact

ICOS-Deficient Regulatory T Cells Can Prevent Spontaneous Autoimmunity but Are Impaired in Controlling Acute Inflammation.

J Immunol 2022 Jun 27. Epub 2022 Jun 27.

Institut de Recherches Cliniques de Montréal, Montreal, QC, Canada;

ICOS is induced in activated T cells and its main role is to boost differentiation and function of effector T cells. ICOS is also constitutively expressed in a subpopulation of Foxp3 regulatory T cells under steady-state condition. Studies using ICOS germline knockout mice or ICOS-blocking reagents suggested that ICOS has supportive roles in regulatory T (Treg) cell homeostasis, migration, and function. Read More

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Providing organic macro minerals and an elevated platform improved tibia characteristics, and increased locomotion and performance of fast- and slower-growing broilers.

Poult Sci 2022 May 21;101(8):101973. Epub 2022 May 21.

Wageningen Livestock Research, Wageningen University and Research, PO Box 338, 6700 AH Wageningen, The Netherlands.

Improving leg health will support broiler health and welfare. Known factors to improve leg health are: replacing inorganic by organic macro minerals in the diet, providing environmental enrichments and using slower-growing broilers. However, it remains unknown how fast- and slower-growing broilers respond to a combination of providing organic macro minerals and an elevated platform as enrichment with regard to leg health. Read More

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S1 guideline: Differential diagnosis of acute and chronic redness of the lower legs.

J Dtsch Dermatol Ges 2022 Jun 27. Epub 2022 Jun 27.

Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.

Acute or chronic redness of the lower leg is a frequent reason for visits to clinics and practices. The differential diagnosis is often challenging. The aim of this guideline is to define criteria and procedures for the differential diagnosis of acute or chronic, unilateral or bilateral redness of the lower leg. Read More

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Confirmatory Virucidal Activity of Ionised Active Water S-100® on the SARS-CoV-2 Virus.

Adv Virol 2022 17;2022:5995775. Epub 2022 Jun 17.

Aix Marseille University, IRD, AP-HM, MEPHI, 13005 Marseille, France.

Ionised active water S-100® has been proposed as an original solution for use in dermocosmetics and for the treatment of wounds such as burns and atopic dermatitis. Among the mechanisms of action that are not completely understood, an antimicrobial activity would appear to be important. In the context of the COVID-19 pandemic, we assessed the inactivating efficacy of this solution on SARS-CoV-2 based on the recommendations of the NF-EN-14476+A2 standard. Read More

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Trends in dermatological practice in work with patients with skin diseases during the COVID-19 pandemic: our experience and observations.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):71-73

Department of Dermatovenereology, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.

The COVID-19 pandemic has changed many areas of life, including habits and trends in dermatological practice and dermatology patients' lifestyles. This article presents cases of patients infected with COVID-19, patients that developed lesions due to pandemic-related public health measures affecting the skin, and those that developed skin lesions after COVID-19 vaccination. One case concerned a female patient with widespread urticaria that had repeatedly gone to emergency rooms and had been administered corticosteroids and antihistamines for an undiagnosed COVID-19 infection that had been triggering her urticaria outbreaks. Read More

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[Translated article] Contact Dermatitis to Allergens in the Spanish Standard Series: Patch Test Findings in the South of Gran Canaria.

Actas Dermosifiliogr 2022 Jun 10;113(6):T555-T562. Epub 2022 May 10.

Servicio de Dermatología, Complejo Hospitalario Universitario Insular Materno Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

Background And Objectives: Contact dermatitis is a common reason for consultation in dermatology. Sensitization levels and frequency, however, vary from one population to the next. The aim of this study was to review patch test results showing sensitization to allergens in the Spanish standard series in the Canary Islands, where a large proportion of the population works in tourism. Read More

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[Translated article] Contact Allergy in Patients With Rosacea.

Actas Dermosifiliogr 2022 Jun 10;113(6):T550-T554. Epub 2022 May 10.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, Spain.

Background And Objective: Rosacea is a chronic acneiform skin disorder in which impaired skin barrier function can lead to sensitization to allergens. We aimed to analyze contact allergies in our patients with rosacea.

Material And Methods: Retrospective cohort study of all patients who underwent patch testing in our skin allergy clinic between May 1991 and May 2019. Read More

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Changes in the Oxidation-Reduction State of Human Dermal Fibroblasts as an Effect of Lomefloxacin Phototoxic Action.

Cells 2022 Jun 19;11(12). Epub 2022 Jun 19.

Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Phototoxicity induced by antibiotics is a real problem in health care. The discontinuation of antibiotic therapy due to a phototoxic reaction can lead to the development of resistant strains. Fluoroquinolones are widely used antibiotics that exhibit phototoxic activity under UVA radiation. Read More

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Occupational hand eczema reduces career length in hairdressers: a prospective cohort study of Danish hairdressers graduating from 1985 to 2007.

Occup Environ Med 2022 Jun 23. Epub 2022 Jun 23.

National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Occupational hand eczema (OHE) is common in hairdressers, and many leave the trade because of the disease. However, the exact impact of OHE on career length is unknown.

Objective: To assess the effect of OHE on career length and risk factors associated with leaving the trade because of OHE in hairdressers followed-up for up to 35 years. Read More

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Anticancer treatments and photosensitivity.

V Sibaud

J Eur Acad Dermatol Venereol 2022 Jun;36 Suppl 6:51-58

Oncodermatology Department, Claudius REGAUD Institute and Cancer University Institute, Toulouse Oncopole, Toulouse Cedex 9, France.

Drug-induced photosensitivity is associated with a wide range of anticancer treatments, including conventional chemotherapeutic agents, targeted anticancer therapies, and immune checkpoint inhibitors. These dermatologic adverse events can have a major impact on the well-being and quality of life of cancer patients, leading to dose modifications and interruption or discontinuation of anticancer treatments in severe cases. However, the heterogeneous nature of the photosensitive reactions induced by these agents, as well as the common concomitant use of other potentially photosensitizing drugs (antibiotics, voriconazole, nonsteroidal anti-inflammatory drugs, etc. Read More

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Patch testing with the European baseline series and 10 added allergens: single centre study of 748 patients.

Contact Dermatitis 2022 Jun 23. Epub 2022 Jun 23.

Faculty of Medicine, University of Maribor, Maribor, Slovenia.

Background: The European baseline series (EBS) of contact allergens is subject to change. An allergen is considered for inclusion when routine patch testing of patients with suspected contact dermatitis results in ≥ 0.5% prevalence rate. Read More

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Scabies: An Itchy Twitch.

Cureus 2022 May 18;14(5):e25120. Epub 2022 May 18.

Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, USA.

One of the most common and contagious infectious dermatological pathology is scabies. It is caused by tiny mites and spreads via skin-to-skin contact. It is most prevalent in children, the elderly, and the immunocompromised. Read More

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Inhibitory activity of soybean (Glycine max L. Merr.) Cell Culture Extract on tyrosinase activity and melanin formation in alpha-melanocyte stimulating Hormone-Induced B16-F10 melanoma cells.

Mol Biol Rep 2022 Jun 22. Epub 2022 Jun 22.

Faculty of Sciences, Department of Biology, Biotechnology Division, Istanbul University, 34452, Istanbul, Turkey.

Background: Hyperpigmentation, which causes excessive melanin synthesis and accumulation, is an important issue in the cosmetic industry. Since compounds developed against hyperpigmentation often come with side effects such as skin irritation and contact dermatitis, new studies focus on the use of natural agents that have no side effects.

Methods And Results: In this study, it was found that the effects of soybean cell culture extract (SCE) on alpha-melanocyte-stimulating hormone (α-MSH) induced melanogenesis in B16-F10 murine melanoma cells. Read More

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Ocular allergy in children and adolescents.

Allergol Immunopathol (Madr) 2022 20;50(S Pt 1):30-36. Epub 2022 May 20.

Federal University of Parana, Curitiba, Brazil.

The association between symptoms of asthma, rhinoconjunctivitis (RC) and allergic conjunctivitis (AC) is frequent, and AC is considered a comorbidity of asthma and allergic rhinitis (AR). Ocular symptoms are often underestimated and undertreated.Differences according to gender were reported, because girls present symptoms more frequently. Read More

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Dermatitis linearis outbreak associated with Paederus balcanicus in Austria.

Wien Klin Wochenschr 2022 Jun 20. Epub 2022 Jun 20.

Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Background: Dermatitis linearis is a toxic skin lesion caused by contact with certain beetles of the genus Paederus (Coleoptera: Staphylinidae). Dermatitis linearis outbreaks have been described mainly in tropical and subtropical regions, but so far not in Central Europe, and are considered an emerging public health concern potentially associated with climate change.

Material And Methods: Following diagnosis of dermatitis linearis in a cluster of six adults and one child with reported exposure to beetles with morphological characteristics of Paederus species at a recreational public open-air bath at Lake Neusiedl (Illmitz, Burgenland, Austria), we performed on-site inspection and installed light and pitfall traps. Read More

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Effects of ultra-pure soft water on the hands of nurses in a neonatal intensive care unit: a randomized crossover study.

Contact Dermatitis 2022 Jun 19. Epub 2022 Jun 19.

Clinical Research Support Center, Tokyo Metropolitan Children's Medical Center, 2-8-9 Musashidai, Fuchu, Tokyo, Japan.

Background: Healthcare workers (HCWs) wash their hands with tap water (TW) and soap. However, hard TW causes dermatitis.

Objectives: The present study aimed to compare the effects of ultra-pure soft water (UPSW) with those of TW on the hands of HWCs. Read More

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Black-Spot Toxicodendron Dermatitis With Varied Presentation.

Wilderness Environ Med 2022 Jun 16. Epub 2022 Jun 16.

School of the Environment, Geography and Geosciences, University of Portsmouth, Portsmouth, UK.

This article describes the clinical presentation, differential diagnosis, and treatment of 2 unrelated cases with different presentations of black-spot Toxicodendron dermatitis. In the first case, a healthy 7-y-old male presented with a rash consisting of black dots with localized surrounding erythema on the left arm. The rash then progressed to a vesicular, pinpoint, raised rash spreading to the face, arms, and neck. Read More

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Cimetidine and Racecadotril : Unusual Culprit Drugs of a Severe Cutaneous Adverse Reaction.

Contact Dermatitis 2022 Jun 17. Epub 2022 Jun 17.

Service de Dermatologie, AP-HP, Hôpital Henri Mondor, Créteil, France.

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A closer look at allergic contact dermatitis caused by topical ophthalmic medications.

Contact Dermatitis 2022 Jun 17. Epub 2022 Jun 17.

Dermatology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Background: Allergic contact dermatitis caused by topical ophthalmic medications (OftACD) is frequently difficult to confirm with patch testing and, therefore, it is considered uncommon.

Methods: We collected retrospective data from a cohort of 65 patients with suspected OftACD patch tested in our Dermatology Unit (2005-2021) according to ESCD guidelines, using a series of topical drugs and excipients (Chemotechnique Diagnostics™), including betaxolol and timolol 5% pet. kindly supplied by the pharmaceutical industry. Read More

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Occupational allergic contact dermatitis to sodium metabisulfite in shredded coconut.

Contact Dermatitis 2022 Jun 17. Epub 2022 Jun 17.

Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

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Hand dermatitis aggravated by contact allergy to methylisothiazolinone in protective nitrile gloves.

Contact Dermatitis 2022 Jun 15. Epub 2022 Jun 15.

Dermatology Department, Geneva Hospitals, University of Geneva, Geneva, Switzerland.

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Recent Developments and Advances in Atopic Dermatitis: A Focus on Epidemiology, Pathophysiology, and Treatment in the Pediatric Setting.

Paediatr Drugs 2022 Jul 13;24(4):293-305. Epub 2022 Jun 13.

University of Miami Miller School of Medicine, Miami, FL, USA.

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects a substantial number of children and has a significant negative impact on affected patients and their caregivers/families. Recent studies have led to significant evolutions in the understanding of AD pathogenesis, epidemiology, and treatment. The first point of contact for many patients with new-onset AD is usually with their primary care provider or pediatrician. Read More

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Assessment of personal inhalation and skin exposures to polymeric methylene diphenyl diisocyanate during polyurethane fabric coating.

Toxicol Ind Health 2022 Jun 13:7482337221107243. Epub 2022 Jun 13.

Yale Occupational and Environmental Medicine Program, 12228Yale School of Medicine, New Haven, CT, USA.

Methylene diphenyl diisocyanate (MDI) monomers and polymeric MDI (pMDI) are aromatic isocyanates widely used in the production of polyurethanes. These isocyanates can cause occupational asthma, hypersensitivity pneumonitis, as well as contact dermatitis. Skin exposure likely contributes toward initial sensitization but is challenging to monitor and quantitate. Read More

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Arerugi 2022 ;71(4):313-320

Hanamizuki Clinic.

Background: Ten percent efinaconazole nail solution (EFCZ solution) is a new topical triazole antifungal drug, and we sometimes encounter patients with allergic contact dermatitis (ACD) caused by EFCZ solution in our outpatient clinic. However, no previous reports have summarized the patch test (PT) results obtained for individual ingredients in several patients with EFCZ solution-induced ACD.

Objectives: This study aimed to 1) confirm the causative agent of EFCZ solution-induced ACD based on PT of individual ingredients and 2) analyze the optimal concentration and vehicle for such PT on the basis of previous studies. Read More

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The immediate patch test reaction to fragrance in patients with allergic contact dermatitis to fragrance: A prospective study.

J Am Acad Dermatol 2022 Jun 8. Epub 2022 Jun 8.

Center of Excellence in Immunology and Immune-Mediated Diseases, Division of Immunology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Background: Fragrance is one of the common causes of immediate contact reaction. Knowing the population's prevalence enables prioritization of allergy screening.

Objective: The purpose of this study is to determine the prevalence of an immediate patch test reaction to fragrance in patients with fragrance allergic contact dermatitis. Read More

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Skin and respiratory ill-health attributed to occupational face mask use.

Occup Med (Lond) 2022 Jun 11. Epub 2022 Jun 11.

Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK.

Background: Face mask use in the workplace has become widespread since the onset of the Covid-19 pandemic and has been anecdotally linked to adverse health consequences.

Aims: To examine reports of adverse health consequences of occupational face mask use received by The Health and Occupation Research (THOR) network before and after the pandemic onset.

Methods: THOR databases were searched to identify all cases of ill-health attributed to 'face mask' or similar suspected causative agent between 1 January 2010 and 30 June 2021. Read More

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Contact sensitization in pediatric patients with atopic dermatitis: a purpose for a new patch testing serie for the Portuguese population.

Eur Ann Allergy Clin Immunol 2022 Jun 9. Epub 2022 Jun 9.

Department of Dermatology, Coimbra University Hospital Center, Coimbra, Portugal.

Summary: Atopic dermatitis is a common illness in pediatric age. Children with atopic dermatitis are prone to develop cutaneous sensitization due to skin barrier dysfunction and immune dysregulation. Recent studies have shown a higher prevalence of certain allergens, which identification may be clinically relevant and have implications for atopic dermatitis management. Read More

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Delayed-type hypersensitivity reaction to St. John's wort extract confirmed by patch testing.

Contact Dermatitis 2022 Jun 9. Epub 2022 Jun 9.

Department of Respiratory Medicine & Allergy, Homerton Healthcare NHS Foundation Trust, London, UK.

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Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions.

Cytokine 2022 Aug 6;156:155897. Epub 2022 Jun 6.

Immunology Discovery, Janssen Research and Development, San Diego, CA 92121, USA. Electronic address:

The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric receptor composed of IL-36R and the IL-1R accessory protein (IL-1RAcP). Individuals with inactivating mutations in the gene encoding IL-36Ra develop generalized pustular psoriasis, a severe form of psoriasis, a finding which clearly links dysregulated IL-36 pathway activation to inflammatory skin conditions. The purpose of this review is to highlight the cellular source of IL-36 cytokines, the effects of IL-36 signaling across cell types, and the association of IL-36 to a spectrum of inflammatory skin diseases including various forms of psoriasis as well as hidradenitis suppurativa, atopic dermatitis, and allergic contact dermatitis. Read More

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