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    Dermatoses caused by cultural practices: Therapeutic cultural practices.
    J Am Acad Dermatol 2018 Jul;79(1):1-16
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    With globalization and widespread immigration, physicians increasingly encounter patients from varying backgrounds and diverse customs. Although certain cultural practices are widely performed, there is limited medical literature describing their dermatologic and systemic effects and complications. Population diversity and sharing of traditions make it increasingly important for dermatologists to understand the role of cultural practices and recognize physiologic and pathologic sequelae. Read More

    Nickel release from surgical instruments and operating room equipment.
    Dermatol Online J 2018 Apr 15;24(4). Epub 2018 Apr 15.
    Park Nicollet Contact Dermatitis Clinic, Minneapolis, Minnesota, USA.
    Background There has been no systematic study assessing nickel release from surgical instruments and equipment used within the operating suite. This equipment represents important potential sources of exposure for nickel-sensitive patients and hospital staff.

    Objective: To investigate nickel release from commonly used surgical instruments and operating room equipment. Read More

    Pediatric Inpatient and Emergency Dermatology Consultations: A 5-Year Retrospective Analysis.
    P R Health Sci J 2018 Jun;37(2):105-109
    Department of Dermatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR.
    Objective: To characterize and analyze the inpatient and emergency pediatric dermatology consults in our academic hospital center.

    Methods: We reviewed 485 consultations that were done by the University of Puerto Rico Department of Dermatology from July 2007 to June 2012. The date, patient age and gender, consulting service, presumptive diagnosis, final diagnosis, and diagnostic procedures performed were documented for each consult. Read More

    Anti-pruritic and anti-inflammatory effects of oxymatrine in a mouse model of allergic contact dermatitis.
    J Dermatol Sci 2018 May 31. Epub 2018 May 31.
    Guangdong Province Key Laboratory of Pharmacodynamic New Drugs Research College of Pharmacy Jinan University Guangzhou 510632 Guangdong, China. Electronic address:
    Background: Allergic contact dermatitis (ACD) is a highly prevalent inflammatory disease of the skin. As a result of the complex etiology in ACD, therapeutic compounds targeting refractory pruritus in ACD lack efficacy and lead to numerous side effects.

    Objective: In this study, we investigated the anti-pruritic effects of oxymatrine (OMT) and explored its mechanism of action in a mouse model of ACD. Read More

    Glove-Related Allergic Contact Dermatitis.
    Dermatitis 2018 Jan/Feb;29(1):13-21
    Hand dermatitis is a common condition with a lifetime prevalence of 20%. Glove allergic contact dermatitis (ACD) is a very important dermatitis affecting health care workers, hairdressers, cleaning personnel, kitchen workers, craftsmen, construction workers, laboratory workers, and homemakers. Occupationally related cases may be severe and can result in significant disability. Read More

    Analysis of possible structures of inducible skin-associated lymphoid tissue in lupus erythematosus profundus.
    J Dermatol 2018 Jun 13. Epub 2018 Jun 13.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    Lupus erythematosus profundus (LEP) is a variant of lupus erythematosus, involving the deep dermis and subcutaneous fat. LEP is characterized by the presence of lymphoid follicles (LF) and germinal centers (GC). However, it remains unknown whether these lymphoid structures correspond to the lymphoid tissues such as cutaneous tertiary lymphoid organs (TLO). Read More

    Aggregate consumer exposure to isothiazolinones via household care and personal care products: Probabilistic modelling and benzisothiazolinone risk assessment.
    Environ Int 2018 Jun 9;118:245-256. Epub 2018 Jun 9.
    Institute for Chemical and Bioengineering, ETH Zürich, Zürich, Switzerland.
    Consumers regularly use household care and personal care products (HC&PCPs). Isothiazolinones are included in HC&PCPs as preservatives and are being held responsible for an epidemic rise in allergic contact dermatitis (ACD). The objective of this study was to assess the origin and extent of dermal exposure in order to evaluate the risk of ACD from isothiazolinones in HC&PCP. Read More

    Effectiveness of interventions for preventing occupational irritant hand dermatitis: a quantitative systematic review.
    JBI Database System Rev Implement Rep 2018 Jun;16(6):1398-1417
    The Scottish Centre for Evidence-based Multi-professional Practice: a Joanna Briggs Institute Centre of Excellence.
    Objective: The aim of this review was to identify, appraise and synthesize the best available evidence on the effectiveness of moisturizers, barrier creams, protective gloves, skin protection education and complex interventions (a combination of two or more of the interventions listed here) in preventing occupational irritant hand dermatitis (OIHD) in wet workers, comparing each intervention to an alternative intervention or to usual care (workers' regular skin care regimen).

    Introduction: The most significant occupational skin problem potentially encountered in wet work occupations is occupational dermatitis. When the skin comes into contact with hazardous substances at work, this can cause occupational dermatitis. Read More

    The role of skin barrier in occupational contact dermatitis.
    Exp Dermatol 2018 Jun 12. Epub 2018 Jun 12.
    Coronel Institute of Occupational Health, Amsterdam Public Health Research Institute, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
    Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis, which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) accounts for vast majority of occupational skin diseases, especially in occupations associated with frequent skin contact with irritants and contact allergens. Although ICD and ACD have similar clinical manifestation, their pathophysiology and the role of the skin barrier is different. Read More

    Possible Roles of Basophils in Chronic Itch.
    Exp Dermatol 2018 Jun 12. Epub 2018 Jun 12.
    Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.
    Basophils are blood granulocytes and normally constitute less than 1% of blood peripheral leukocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Read More

    Health impact assessment of a skin sensitizer: Analysis of potential policy measures aimed at reducing geraniol concentrations in personal care products and household cleaning products.
    Environ Int 2018 Jun 8;118:235-244. Epub 2018 Jun 8.
    National Institute for Public Health and the Environment, Centre for Safety of Substances and Products, Bilthoven, The Netherlands.
    A methodology to assess the health impact of skin sensitizers is introduced, which consists of the comparison of the probabilistic aggregated exposure with a probabilistic (individual) human sensitization or elicitation induction dose. The health impact of potential policy measures aimed at reducing the concentration of a fragrance allergen, geraniol, in consumer products is analysed in a simulated population derived from multiple product use surveys. Our analysis shows that current dermal exposure to geraniol from personal care and household cleaning products lead to new cases of contact allergy and induce clinical symptoms for those already sensitized. Read More

    Allergic contact dermatitis caused by acrylic-based medical dressings and adhesives.
    Contact Dermatitis 2018 Jun 11. Epub 2018 Jun 11.
    Department of Dermatology, University Hospitals KU Leuven, Leuven, Belgium.
    Background: Acrylates and methacrylates are acrylic resin monomers that are known to induce skin sensitization as a result of their presence in different materials, such as nail cosmetics, dental materials, printing inks, and adhesives. Allergic contact dermatitis resulting from the use of modern wound dressings containing them has only rarely been reported.

    Objectives: To describe 2 patients who developed allergic contact dermatitis caused by acrylic-based modern medical dressings and/or adhesives. Read More

    Metal hypersensitivity in patients with orthopaedic implant complications-A retrospective clinical study.
    Contact Dermatitis 2018 Jun 11. Epub 2018 Jun 11.
    Department of Dermatology, Allergy Unit, University Hospital, Basel, Switzerland.
    Background: Hypersensitivity to metals as a cause of implant-related complications has been a subject of controversy. Projections indicate an increase in the frequency of joint replacements of between 300% and 600% by the year 2030; therefore, this issue is of considerable interest.

    Objective: To evaluate sensitization to implant materials in patients with implant-related complications, to identify allergens, and to clarify whether hypersensitivity is a relevant cause. Read More

    Tandem Repeated Irritation Test (TRIT) Studies and Clinical Relevance: Post 2006.
    Cutan Ocul Toxicol 2018 Jun 11:1-17. Epub 2018 Jun 11.
    b Department of Dermatology , University of California , San Francisco , CA , USA.
    Background/aims: Single or multiple applications of irritants can lead to occupational contact dermatitis, and most commonly irritant contact dermatitis (ICD). Tandem irritation, the sequential application of two irritants to a target skin area, has been studied using the Tandem Repeated Irritation Test (TRIT) to provide a more accurate representation of skin irritation.

    Objective: Here we present an update to Kartono's review on tandem irritation studies since 2006 [1]. Read More

    Is a specific eyelid patch test series useful? Results of a French prospective study.
    Contact Dermatitis 2018 Jun 8. Epub 2018 Jun 8.
    Department of Dermatology, CHU Montpellier, Montpellier, France.
    Background: Eyelids are frequent sites of contact dermatitis. No prospective study focused on eyelid allergic contact dermatitis (EACD) has yet been published, and this topic has never been studied in French patients.

    Objectives: To prospectively evaluate the usefulness of an eyelid series in French patients patch tested because of EACD, and to describe these patients. Read More

    Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessment.
    Methods Mol Biol 2018 ;1803:101-116
    Cardiopulmonary and Immunotoxicology Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Triangle Park, NC, USA.
    Allergic contact dermatitis (ACD) continues to be an occupational and environmental health issue. Consequently, there is a need to employ predictive tests to reduce the incidence of skin sensitization leading to clinical manifestations of ACD. For more than a decade, the murine local lymph node assay (LLNA) has been the method of choice for the identification of skin sensitizers. Read More

    Methylated Bovine Serum Albumin (mBSA)-Induced Delayed-Type Hypersensitivity in Mice.
    Methods Mol Biol 2018 ;1803:95-99
    Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
    Delayed-type hypersensitivity (DTH or type IV hypersensitivity) is defined by T-cell-driven inflammation which occurs only after secondary insult with antigen. Interestingly both Th1, the classical, and Th17, the more recently discovered, proinflammatory lineages have been implicated in disease progression. The duality of DTH makes it an ideal model system for understanding T-cell differentiation, memory cell formation, and the direct effect of treatment regimens on T-cell activation/proliferation. Read More

    Food-Related Contact Dermatitis, Contact Urticaria, and Atopy Patch Test with Food.
    Clin Rev Allergy Immunol 2018 Jun 7. Epub 2018 Jun 7.
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Frauenlobstr. 9-11, 80337, Munich, Germany.
    A wide variety of foods may cause or aggravate skin diseases such as contact dermatitis, contact urticaria, or atopic dermatitis (AD), both in occupational and private settings. The mechanism of action underlying allergic disease to food, food additives, and spices may be immunologic and non-immunologic. The classification and understanding of these reactions is a complex field, and knowledge of the possible reaction patterns and appropriate diagnostic test methods is essential. Read More

    [When sunscreens do not help: allergic contact dermatitis to UV filters].
    Hautarzt 2018 Jun 7. Epub 2018 Jun 7.
    Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07740, Jena, Deutschland.
    Ultraviolet (UV) filters may cause allergic and more frequently photoallergic contact dermatitis. Therefore, a photopach test should always be performed in case of a suspected contact sensitivity to UV filters. We report a case of a 65-year-old woman with a recurrent erythema of the face and décolleté after sun exposure despite application of a sunscreen. Read More

    From Probiotic to Prebiotic Using Thermal Spring Water.
    J Drugs Dermatol 2018 Jun;17(6):657-662
    Background: La Roche-Posay Thermal Spring Water (LRP-TSW) exhibits both probiotic and prebiotic properties enhancing the diversity of the skin microbiota.

    Methods: A review was undertaken to explore the role of LRP-TSW as a topical probiotic and prebiotic therapy in improving the diversity of the skin microbiota and reducing dryness and pruritus in inflammatory skin diseases.

    Results: The concentration of minerals and non-pathogenic microbes in LRP-TSW may explain its therapeutic benefit when used for inflammatory skin diseases. Read More

    Cinnamic acid derivatives in cosmetics - current use and future prospects.
    Int J Cosmet Sci 2018 Jun 5. Epub 2018 Jun 5.
    Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, Poland.
    Cinnamic acid derivatives are widely used in cosmetics and possess various functions. This group of compounds includes both naturally occurring as well as synthetic substances. On the basis of the Cosmetic Ingredient Database (CosIng) and available literature, this review summarizes their functions in cosmetics, including their physicochemical and biological properties as well as reported adverse effects. Read More

    Cutaneous acceptability of a moisturizing cream in subjects with sensitive skin.
    J Cosmet Dermatol 2018 May 31. Epub 2018 May 31.
    GSK Consumer Healthcare, Weybridge, Surrey, UK.
    Background: Topical cosmetic products can cause adverse reactions in some individuals, particularly those with sensitive skin who may develop irritations or allergic contact dermatitis. Evidence suggests that the frequency of self-reported sensitive skin is increasing in the general population, placing greater importance on clinical testing of topical cosmetics for potential skin reactivity.

    Objectives: To confirm the cutaneous acceptability under normal conditions of use of a moisturizing cream in individuals with sensitive skin. Read More

    P-Phenylenediamine Hair Dye Allergy and Its Clinical Characteristics.
    Ann Dermatol 2018 Jun 23;30(3):316-321. Epub 2018 Apr 23.
    Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Background: P-phenylenediamine (PPD) has been identified as the most frequent contact sensitizer of hair dye and the clinical characteristics of hair dye contact allergy (HDCA) are diverse.

    Objective: The purpose of this study was to identify the clinical characteristics of HDCA and to assess the relationships between HDCA, exposure time to PPD and PPD positivity.

    Methods: We analyzed 105 patients with patch test-confirmed hair dye allergy who presented between July 2009 and March 2015. Read More

    Welfare assessment of conventional and organic broilers in Denmark, with emphasis on leg health.
    Vet Rec 2018 May 30. Epub 2018 May 30.
    Department of Animal Science, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark.
    The aim of this study was to survey and report the walking ability in broilers housed in both conventional and organic production systems in Denmark. To this end, the authors assessed the walking ability, by using the Bristol scale, in 31 conventional broiler flocks and in 29 organic broiler flocks distributed across Denmark. In addition, assessment of contact dermatitis, leg abnormalities, scratches and plumage cleanliness, as well as postmortem analysis of tibial dyschondroplasia, was performed in conventional broilers. Read More

    Adolescents' Perspectives on Atopic Dermatitis Treatment: Experiences, Preferences, and Beliefs.
    JAMA Dermatol 2018 May 30. Epub 2018 May 30.
    Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
    Importance: For a considerable proportion of pediatric patients, atopic dermatitis symptoms persist into adolescence. Previous studies have focused mainly on (parents of) children, whereas little is known about adolescents with atopic dermatitis.

    Objective: To explore the beliefs, experiences, and preferences of adolescents with atopic dermatitis toward their treatment. Read More

    Methylisothiazolinone contact allergy in Croatia: Epidemiology and course of disease following patch testing.
    Contact Dermatitis 2018 May 30. Epub 2018 May 30.
    National Allergy Research Centre, Department of Dermatology and Allergy, Herlev Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Background: Methylisothiazolinone (MI) caused an epidemic of contact allergy in Europe, as shown by data from many countries, but no studies from Croatia exist. Also, data are lacking on the severity of allergic contact dermatitis (ACD) caused by MI, and its impact on quality of life and prognosis.

    Objectives: To determine the frequency of MI contact allergy among Croatian dermatitis patients, identify causative exposures, assess the impact of disease, and study the prognosis. Read More

    Extended documentation for hand dermatitis patients: Pilot study on irritant exposures.
    Contact Dermatitis 2018 May 30. Epub 2018 May 30.
    Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Background: Irritant exposure may be a contributory cause or the sole cause of (occupational) hand dermatitis. However, the documentation of irritant exposures in clinical practice is not standardized.

    Objectives: To examine the feasibility and usefulness of a form with different items addressing both occupational and non-occupational irritant exposures in a semiquantitative way. Read More

    Solvent Orange 60 is a potent contact sensitizer in occupational and everyday life.
    Contact Dermatitis 2018 May 30. Epub 2018 May 30.
    Department of Occupational and Environmental Dermatology, Lund University, Skane University Hospital, Malmö, Sweden.
    Background: Solvent Orange (SO) 60 is a perinone-type dye that is often used in plastic materials such as spectacle frames and has been shown to cause contact allergy. The first case of SO 60 allergic contact dermatitis caused by spectacle frames was reported in 1999, and the second in 2011. We have recently seen 10 patients, of whom 6 developed dermatitis in the retroauricular/temporal area after wearing plastic spectacles. Read More

    Contact Allergy: A Review of Current Problems from a Clinical Perspective.
    Int J Environ Res Public Health 2018 May 29;15(6). Epub 2018 May 29.
    Department of Dermatology and Allergy, National Allergy Research Centre, Copenhagen University Hospital Herlev and Gentofte, 2900 Hellerup, Denmark.
    Contact allergy is common, affecting 27% of the general population in Europe. Original publications, including case reports, published since 2016 (inclusive) were identified with the aim of collating a full review of current problems in the field. To this end, a literature search employing methods of systematic reviewing was performed in the Medline and Web of Science™ databases on 28 January 2018, using the search terms ("contact sensitization" or "contact allergy"). Read More

    Contact dermatitis to training toilet seat (potty seat dermatitis).
    Pediatr Dermatol 2018 May 29. Epub 2018 May 29.
    Department of Dermatology, Penn State/Hershey Medical Center, Hershey, PA, USA.
    Allergic contact dermatitis from various components of toilet seats has been well described. We report a case of a young boy presenting with an atypical pattern of dermatitis who was found to be allergic to his training toilet seat. This case highlights the importance of recognizing this diagnosis and the role of potty seats as the causative factor. Read More

    Silkworm dropping extract ameliorate trimellitic anhydride-induced allergic contact dermatitis by regulating Th1/Th2 immune response.
    Biosci Biotechnol Biochem 2018 May 26:1-8. Epub 2018 May 26.
    a Food Biotechnology Program , Korea University of Science and Technology , Republic of Korea.
    Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by hapten-specific immune response. Silkworm droppings are known to exert beneficial effects during the treatment of inflammatory diseases. Here, we studied whether topical treatment and oral administration of silkworm dropping extract (SDE) ameliorate trimellitic anhydride (TMA)-induced ACD. Read More

    Allergy to acrylate in composite in an orthodontic patient: a case report.
    J Orthod 2018 May 28:1-7. Epub 2018 May 28.
    a Orthodontic Department , Leeds Dental Institute , Leeds , UK.
    Acrylate allergies have been reported in dental professionals as a result of repeat exposure to various acrylate monomers and in dental patients with removable prostheses or longstanding composite restorations. To date, there is only one report of an allergic reaction in a young patient from small volumes of resin-based orthodontic adhesive. This case report demonstrates a recent case of gingival inflammation and lip oedema attributed to an acrylate allergy arising from the composite adhesive used with fixed appliances. Read More

    A retrospective study on titanium sensitivity: Patch test materials and manifestations.
    Contact Dermatitis 2018 May 24. Epub 2018 May 24.
    Department of Dermatology, VU University Medical Centre, Amsterdam, The Netherlands.
    Background: Titanium is being increasingly used. Although it is considered to be a non-allergenic material, allergic reactions to it have been reported. Titanium dioxide has been found to be an unreliable patch test material. Read More

    Beneficial Effects of Antioxidant Furfuryl Palmitate in Non-pharmacologic Treatments (Prescription Emollient Devices, PEDs) for Atopic Dermatitis and Related Skin Disorders.
    Dermatol Ther (Heidelb) 2018 May 22. Epub 2018 May 22.
    Dipartimento di Scienze biomediche, chirurgiche e odontoiatriche, Clinica Dermatologica, Università degli Studi di Milano, Milan, Italy.
    Introduction: Atopic dermatitis (AD) is a common chronic inflammatory skin disease; it requires long-term treatments focused on symptomatic relief. Current first-line treatments include moisturizers and topical corticosteroids. Recently, topical antioxidants have been added to moisturizer formulations to alleviate mild-to-moderate AD. Read More

    [The rationale for the application of photomagnetic therapy in the treatment of dermatitis].
    Vopr Kurortol Fizioter Lech Fiz Kult 2018 May 21;95(2):25-36. Epub 2018 May 21.
    Institute of Physiology of the National Academy of Sciences of Belarus.
    Background: in spite of the fact that photomagnetic therapy with the use of the FotoSPOK device (Magnomed Ltd., Belarus) is already used in the medical practice, the application of this method for the management of many diseases remains to be substantiated on the scientifically sound grounds.

    Aim: The objective of the present study was to evaluate the effectiveness of photomagnetic therapy in the treatment of the local inflammatory process in the skin and to elaborate the rationale for the application of this technique in the treatment of contact dermatitis. Read More

    Skin lesions over the pocket area that may mimic cardiac implantable electronic device infection: A case series.
    Pacing Clin Electrophysiol 2018 May 21. Epub 2018 May 21.
    Arrhythmia Device and Electrophysiology Laboratory, University Hospital of Ioannina, Ioannina, Greece.
    Background: The early and correct diagnosis of cardiac implantable electronic device (CIED) infections is critical given that early aggressive treatment with complete removal of the system along with antimicrobial therapy dramatically improves outcomes. Pocket infection manifested by local signs of inflammation is the most common form of CIED infections. Conditions mimicking pocket infection have been described in the literature. Read More

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