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    Dermatology in Ghana: a retrospective review of skin disease at the Korle Bu Teaching Hospital Dermatology Clinic.
    Pan Afr Med J 2017 3;26:125. Epub 2017 Mar 3.
    The Ronald Perelman Department of Dermatology, New York University School of Medicine, USA.
    Introduction: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. Read More

    [CHRONIC DERMATITIS OF THE DORSUM OF THE FEET AND SHINS, DUE TO ALLERGIC CONTACT DERMATITIS TO LEATHER PRODUCTS].
    Harefuah 2016 Oct;155(10):608-610
    Department of Dermatology, Hadassah Hebrew University Medical Center, Jerusalem Israel.
    Introduction: A 40 year old woman presented with dermatitis mainly involving her dorsal feet and shins, a condition which was present for a prolonged period of time. The distribution was suggestive of allergic contact dermatitis, possibly to her shoes. Patch tests disclosed allergy to chromates, cobalt, colophony, all present in leather products, and allergy to myroxylon pereirae (Balsam of Peru). Read More

    Diagnosis and management of allergic contact dermatitis in children: common allergens that can be easily missed.
    Curr Opin Pediatr 2017 May 18. Epub 2017 May 18.
    aDepartment of Dermatology bDepartment of Medicine, Loma Linda University, Loma Linda, California, USA cDepartment of Dermatology, Crosshouse Hospital, Kilmarnock, Scotland, UK.
    Purpose Of Review: Contact dermatitis is an economically burdensome pediatric disease, and it is important to know the top allergens that have remained as top offenders for over the last decade.

    Recent Findings: A comparative analysis of the 20-allergen screen was done against the current top 40 pediatric allergens, and it revealed that the 20-allergen screening series would have theoretically only captured 47.5% of the relevant contact allergens (52. Read More

    Quantification of l-carvone in toothpastes available on the Swedish market.
    Contact Dermatitis 2017 May 19. Epub 2017 May 19.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. Read More

    Allergic Contact Dermatitis Due to Methylisothiazolinone in a Young Girl's Laundry Detergent.
    Pediatr Dermatol 2017 May 19. Epub 2017 May 19.
    Department of Dermatology, University of California, San Diego, Rady Children's Hospital, San Diego, California.
    Methylisothiazolinone (MI) is an emerging and increasing cause of allergic contact dermatitis (ACD) in children. We present the case of a 7-year-old girl with an unusual dermatitis suspicious for contact allergy. Patch testing confirmed allergy to MI, found only in the patient's laundry detergent. Read More

    Anti-allergic and Profilaggrin (ProFLG)-mRNA Expression Modulatory Effects of Sacran.
    Int J Biol Macromol 2017 May 15. Epub 2017 May 15.
    Graduate School of Advanced Science and Technology, Energy and Environment Area, Japan Advanced Institute of Science and Technology, Nomi, Japan. Electronic address:
    Atopic dermatitis (AD) is a skin disorder characterized by filaggrin (FLG) defect. We evaluated sacran's effects on dust-mite extracts (DME)-induced AD-like disease and also its effect on profilaggrin (proFLG) in a murine model of 2,4-dinitroflurobenze (DNFB)-induced contact hypersensitivity. In the murine AD-like disease model, allergic NC/Nga mice (N=60) were randomly divided into five treatment groups of 12 animals each: 0. Read More

    [Skin diseases associated with environmental factors].
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2017 May 17. Epub 2017 May 17.
    Abteilung Allergologie, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225, Langen, Deutschland.
    Background: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease.

    Objectives: Provide an overview of non-allergic skin diseases associated with environmental factors.

    Materials And Methods: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. Read More

    Occupational contact allergy to omeprazole and ranitidine.
    Med Pr 2017 May 20;68(3):433-435. Epub 2017 Mar 20.
    University of Barcelona, Barcelona, Spain (Unit of Occupational Medicine, School of Medicine).
    Omeprazole is a proton pump inhibition and ranitidine is an H2 histamine receptor antagonist widely used in the treatment of gastroesophageal reflex disease, peptic ulcer disease, Zollinger-Ellison syndrome and as a protector of the gastric mucosae. We report a case of occupational contact allergy to omeprazole and ranitidine. A 48-year-old man, with no pre-existing history of atopy or lifestyle factors. Read More

    Non-mix fragrances are top sensitizers in consecutive dermatitis patients - a cross-sectional study of the 26 EU-labelled fragrance allergens.
    Contact Dermatitis 2017 May 16. Epub 2017 May 16.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev-Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Background: For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix I (FM I) and fragrance mix II (FM II). Earlier reports have not included oxidized R-limonene [hydroperoxides of R-limonene (Lim-OOH)] and oxidized linalool [hydroperoxides of linalool (Lin-OOH)], and breakdown testing of FM I and FM II has mainly been performed in selected, mix-positive patients.

    Objectives: To report the prevalence of sensitization to the 26 fragrances, and to assess concomitant reactivity to FM I and/or FM II. Read More

    Multicenter Patch Testing With Methylchloroisothizoline/Methylisothiazolinone in 100 and 200 ppm Within the International Contact Dermatitis Research Group.
    Dermatitis 2017 May/Jun;28(3):215-218
    From the *Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden; †Allergy Center and Department of Dermatology, University Hospital, Republic University of Uruguay, Montevideo; ‡Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark; §Department of Dermatology, University Hospital Jena, Germany; ∥Department of Dermatology, National Skin Center, Singapore, Singapore; ¶Contact Allergy Unit, Department of Dermatology, University Hospital K.U. Leuven, Belgium; #MGM Medical College, Mumbai, India; and **Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
    Background: The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known contact sensitizer. Historically, there have been different opinions on the optimal patch test concentration of MCI/MI, and both 0.01% and 0. Read More

    Epidemic of Isothiazolinone Allergy in North America: Prevalence Data From the North American Contact Dermatitis Group, 2013-2014.
    Dermatitis 2017 May/Jun;28(3):204-209
    From the *Division of Dermatology, The Ohio State University, Columbus; †The University of Minnesota and the Minneapolis VAMC; ‡University of California, San Francisco; §Cleveland Clinic, OH; ∥McGill University Health Centre, Montreal, Canada; ¶University of Toronto, Canada; #Associates in Dermatology, Fort Myers, FL; **Group Health Associates, Cincinnati, OH; ††Dartmouth Medical Center, Lebanon, NH; ‡‡St. Luke's Roosevelt Hospital Center, New York; §§Dermatology Specialists, Louisville, KY; ∥∥Pennsylvania State University, Hershey, PA; ¶¶University of Ottawa, Ontario, Canada; ##Columbia University Medical Center, New York, NY.
    Background: Preservative sensitivity patterns evolve with changing use patterns in products. During the last decade, the use of methylisothiazolinone (MI) at higher concentrations in both leave-on and rinse-off products has significantly increased. This is the first North American Contact Dermatitis Group reporting cycle that includes both methylchloroisothiazolinone (MCI)/MI and MI data. Read More

    Preventing Occupational Skin Disease: A Review of Training Programs.
    Dermatitis 2017 May/Jun;28(3):169-182
    From the *Dalla Lana School of Public Health, University of Toronto, †Department of Occupational Health and Centre for Urban Health Solutions, Li Ka Shing, Knowledge Institute, St Michael's Hospital; ‡Occupational Cancer Research Centre, Cancer Care Ontario; and §Department of Medicine, University of Toronto, Canada.
    Occupational contact dermatitis (OCD) is a common occupational disease that impacts a variety of worker groups. Skin protection and disease prevention training programs have shown promise for improving prevention practices and reducing the incidence of OCD. This review details the features of training programs for primary prevention of OCD and identifies gaps in the literature. Read More

    Skin diseases and tattoos: a five-year experience.
    G Ital Dermatol Venereol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, University of Naples Federico II, Naples, Italy -
    Background: Decorative tattooing as a body art form underwent an exponential increase during the last two decades, particularly among teenagers and young adults. Consequently, the number of reported adverse reactions after tattooing has increased. The most frequent reported skin reactions to tattoo include infectious (bacterial, viral, fungal) or inflammatory (allergic contact dermatitis and granulomatous reaction) diseases. Read More

    Diagnosing Allergic Contact Dermatitis Through Elimination, Perception, Detection and Deduction.
    Am J Clin Dermatol 2017 May 15. Epub 2017 May 15.
    Department of Cutaneous Allergy, St. John's Institute of Dermatology, Guy's Hospital, King's College, London, UK.
    Several authors have commented upon the skills of detection required in making a diagnosis of allergic contact dermatitis. Here, we emphasise the search for clues in a systematic manner. We describe four stages as part of a systematic method for diagnosing allergic contact dermatitis. Read More

    Dermatitis Due to Paederus Colombinus: Report of an Epidemic Outbreak of 68 Cases in the Province of Darien, Panama.
    Cureus 2017 Apr 12;9(4):e1158. Epub 2017 Apr 12.
    Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica De Pereira, Pereira, Risaralda, Colombia.
    Introduction: Contact dermatitis due to Paederus is a particular form of accident by animal contact. It is characterized by the sudden onset of erythematous and vesicular lesions with burning sensation on exposed areas of the body. The aim of this study was to describe the epidemiological and clinical findings of an outbreak of Paederus dermatitis in Panama. Read More

    Allergic contact dermatitis caused by (meth)acrylates in nail cosmetic products in users and nail technicians - a 5-year study.
    Contact Dermatitis 2017 May 15. Epub 2017 May 15.
    Clinic of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, 3000-075, Coimbra, Portugal.
    Background: The increasing use of long-lasting nail aesthetic products has led to a growing number of cases of allergic contact dermatitis (ACD) caused by (meth)acrylates in recent years.

    Objectives: To provide information on ACD caused by (meth)acrylates related to nail cosmetic products.

    Methods: We retrospectively reviewed files of patients with ACD caused by (meth)acrylates related to nail cosmetic products, who were patch tested between January 2011 and December 2015 in 13 departments of dermatology in Portugal. Read More

    Effectiveness of topical skin products in the treatment and prevention of incontinence-associated dermatitis: a systematic review.
    JBI Database System Rev Implement Rep 2017 May;15(5):1473-1496
    1Nursing Research Centre and The Queensland Centre for Evidence-Based Nursing and Midwifery: a Joanna Briggs Institute Centre of Excellence, Mater Health Services, Brisbane, Australia 2School of Nursing, Queensland University of Technology (QUT), Brisbane, Australia 3Intensive Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia.
    Background: Incontinence-associated dermatitis (IAD) is inflammation of the skin resulting from repeated contact with urine and/or feces. It causes pain, redness, swelling and excoriation, and may lead to complications such as fungal skin infections and pressure injuries. It is important to prevent and treat IAD to avoid complications and improve patient outcomes. Read More

    Allergic and nonallergic rhinitis and skin sensitization to metals: is there a link?
    Eur Ann Allergy Clin Immunol 2017 May;49(3):106-109
    Allergy and Respiratory Diseases, IRCCS San Martino-Ist-University of Genoa, Genoa, Italy. Phone: +39 010 353 8904 E-mail:
    Summary: Background. Chromium, Cobalt and Nickel are responsible for contact dermatitis, that is largely prevalent in the general population. They can act also as irritants in the upper and lower respiratory airways. Read More


    Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis.
    Contact Dermatitis 2017 May 12. Epub 2017 May 12.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Read More

    Electro-Acupuncture at Zusanli Acupoint (ST36) Suppresses Inflammation in Allergic Contact Dermatitis Via Triggering Local IL-10 Production and Inhibiting p38 MAPK Activation.
    Inflammation 2017 May 10. Epub 2017 May 10.
    Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Hubei University of Chinese Medicine, 1 Huangjiahu West Road, Hongshan District, Wuhan, Hubei, 430065, China.
    Acupuncture has shown beneficial effect in the treatment of multiple dermatologic conditions including dermatitis, pruritus, urticaria, and hyperhidrosis; however, the detailed mechanisms are still kept unclear. This study aimed to investigate if electro-acupuncture (EA) treatment prevents 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) in rats and explore its underlying mechanisms. ACD was induced by sensitizing and challenging with DNFB topically. Read More

    Evaluation of occupational allergic contact dermatitis and its related factors in Iran.
    Med J Islam Repub Iran 2016 28;30:468. Epub 2016 Dec 28.
    Assistant Professor, Iran University of Medical Sciences, Tehran, Iran.
    Background: Occupational contact dermatitis, especially in hand, is one of the most common occupational disorders. The present study aimed at evaluating patients with occupational allergic contact dermatitis (ACD) caused by common allergens based on occupation type and disease history. Methods: This cross-sectional study aimed at evaluating the data of the patients with probable diagnosis of ACD in Center for Research and Training in Skin Diseases and Leprosy (CRTSDL) in Iran. Read More

    The efficacy of a lip balm containing pseudo-ceramide on the dry lips of sensitive skin-conscious subjects.
    J Cosmet Dermatol 2017 May 9. Epub 2017 May 9.
    Department of Dermatology, Mie University, Mie, Japan.
    Background: Many people use lip care products daily to prevent dry lips. However, some people, especially those with sensitive skin-consciousness, complain of various skin problems on their lips including contact dermatitis caused by lip care products. Dry lips have decreased water holding capacity and cutaneous barrier function as well as reduced stratum corneum ceramide levels. Read More

    Long-lasting insulin treatment via a single subcutaneous administration of liposomes in thermoreversible Pluronic® F127 based hydrogel.
    Curr Pharm Des 2017 May 9. Epub 2017 May 9.
    School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong. China.
    Background: Repeated administrations of insulin injection on daily basis accompany pain and arise numerous complications with adverse effects on the diabetic patients life quality. Moreover, wearing insulin pump is also associated with several problems of diabetic ketoacidosis, catheter site infection, contact dermatitis and high cost.

    Methods: We have developed an in situ gel system, consisting of insulin-loaded liposomes dispersed within a thermoreversible gel (Pluronic® F127 gel), which increases the duration of insulin action for the treatment of diabetes. Read More

    Pilot study of contact sensitization to rubber allergens and bisphenol A amongst dental students.
    Int J Occup Med Environ Health 2017 May 8;30(3):397-405. Epub 2017 Mar 8.
    Medical University - Sofia, Sofia, Bulgaria (Faculty of Dental Medicine, Department "Oral and Image Diagnostic").
    Objectives: The aim of this study has been to evaluate the rate of contact sensitization to some rubber allergens and to bisphenol A (BPA) amongst students of dental medicine and dental patients.

    Material And Methods: A total of 50 participants were included in the study: 40 students of dental medicine exposed to the studied rubber allergens and BPA-based dental materials during the course of their education; 10 dental patients without occupational exposure to the latter substances served as a control group. All of them were patch-tested with the studied rubber allergens and bisphenol A. Read More

    Guideline for translation and national validation of the Quality of Life in Hand Eczema Questionnaire (QOLHEQ).
    Contact Dermatitis 2017 May 8. Epub 2017 May 8.
    Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University Hospital Heidelberg, 69115, Heidelberg, Germany.
    There is a need for well-developed and validated questionnaires to measure patient reported outcomes. The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) is such a validated instrument measuring disease-specific health-related quality of life in hand eczema patients. A re-validation of measurement properties is required before an instrument is used in a new population. Read More

    Contact sensitisation in adults: a 5-year retrospective review in hospital Kuala Lumpur.
    Med J Malaysia 2017 Apr;72(2):113-118
    Hospital Kuala Lumpur, Department of Dermatology, Kuala Lumpur, Malaysia.
    Background: The pattern of contact sensitisation should be monitored in order to detect the changing trend of sensitising allergens. We aim to evaluate contact sensitisation in adults suspected to have allergic contact dermatitis.

    Methods: This is a five-year retrospective review on contact sensitisation in adults patch-tested with the European Standard and extended series between 2011 and 2015 in the Department of Dermatology, Hospital Kuala Lumpur. Read More

    Chemical or drug hypersensitivity: is the immune system clearing the danger?
    Toxicol Sci 2017 May 4. Epub 2017 May 4.
    Inflammation, Chimiokines et Immunopathologie, INSERM, Fac. de pharmacie - Univ.Paris-Sud, Université Paris-Saclay, 92290, Châtenay-Malabry, France.
    Hypersensitivity reaction or allergy, initially perceived as a secondary disorder, is now believed to be a major public health. For instance, contact dermatitis is a type IV delayed-type hypersensitivity reaction to skin allergens. An estimated 15-20% of the general population has acquired contact allergy. Read More

    Contact allergy in children with atopic dermatitis: a systematic review.
    Br J Dermatol 2017 May 3. Epub 2017 May 3.
    Department of Dermatology and Venereology, Aarhus University Hospital.
    The importance of contact allergy in children with atopic dermatitis is frequently debated. Previously, patients with atopic dermatitis were believed to have a reduced ability to produce a type IV immunologic response. However, this belief has been challenged and authors have highlighted the risk of underestimating and overlooking allergic contact dermatitis in children with atopic dermatitis. Read More

    Allergic contact dermatitis following drug rash due to chlorpheniramine maleate.
    Clin Case Rep 2017 May 17;5(5):718-719. Epub 2017 Mar 17.
    Department of General MedicineChiba University HospitalChiba-cityJapan.
    Allergic contact dermatitis (ACD) is one of the common causes of facial swelling. Clinical clues for diagnosing ACD include a rash that spares the area behind the ears, nasolabial folds, and under the chin. Once clinicians suspect ACD, the substances that cause contact dermatitis should be avoided. Read More

    Re "International survey on skin patch test procedures, attitudes and interpretation" L.K. Tanno et al., WAOJ (2016) 9:8.
    World Allergy Organ J 2017 26;10(1):18. Epub 2017 Apr 26.
    Allergy Unit, Department of Dermatology, University Hospital Erlangen, 91054 Erlangen, Germany.
    A previous survey on the practice of diagnostic patch testing among representatives of member societies of the World Allergy Organization (WAO) has, in some countries, not addressed those stakeholders actually involved in patch testing, mainly dermatologists. The need for further standardisation is acknowledged and has been addressed e.g. Read More

    Protein Tyrosine Phosphatase Conjugated with a Novel Transdermal Delivery Peptide, AP-rPTP Alleviates both Atopic Dermatitis-like and Psoriasis-like Dermatitis.
    J Allergy Clin Immunol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea; Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea; Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon 16419, Republic of Korea. Electronic address:
    Background: Atopic dermatitis and psoriasis are the two most common chronic inflammatory skin diseases. There is an unmet medical need to overcome limitations for transcutaneous drug development posed by the skin barrier.

    Objective: We aimed to identify a novel transdermal delivery peptide and to develop a transcutaneously applicable immunomodulatory protein for treating atopic dermatitis and psoriasis. Read More

    E-cadherin-mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis.
    J Invest Dermatol 2017 Apr 26. Epub 2017 Apr 26.
    Institute of Life Sciences, Fuzhou University, Fuzhou, Fujian, China. Electronic address:
    Radiotherapy is a primary oncological treatment modality, which also damages normal tissue including the skin and causes radiation dermatitis (RD). Here, we explore the mechanism of acute epidermal damage in RD. Two distinctive phases in the damage response were identified: an early destructive phase where a burst of reactive oxygen species (ROS) induces loss of E-cadherin-mediated cell contact, followed by a regenerative phase where Wnt and Hippo signaling are activated. Read More

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