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    Ambulatory practice of dermatologists in Taiwan: A nationwide survey.
    J Chin Med Assoc 2018 Feb 16. Epub 2018 Feb 16.
    Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address:
    Background: Skin diseases are among the most common public health problems and cause a significant burden. For policymakers and clinicians, comprehensive and detailed information is necessary to better allocate resources needed to care for skin diseases. This study was conducted to characterize the ambulatory practice of dermatologists in Taiwan. Read More

    Atopy Associated With Positive Patch Test and Possible Allergic Contact Dermatitis.
    J Cutan Med Surg 2018 Feb 1:1203475418758988. Epub 2018 Feb 1.
    2 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
    Background: Atopy is a genetic predisposition to the development of allergic reactions and the increased production of immunoglobulin E (IgE) upon exposure to environmental antigens. Clinical manifestations of atopy include asthma, atopic dermatitis (AD), and allergic rhinoconjunctivitis (ARC).

    Objective: To determine if cutaneous delayed hypersensitivity reactions (CDHRs) as assessed by patch testing are higher among patients with a history of atopy and with a familial predisposition to atopy. Read More

    Impact of hand eczema on quality of life: metropolitan versus non-metropolitan areas.
    Contact Dermatitis 2018 Feb 19. Epub 2018 Feb 19.
    Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, 2400 Copenhagen, Denmark.
    Background: An inverse relationship between disease severity and health-related quality of life (HR-QoL) in patients with hand eczema is well established, but modifying effects of demographic variables have been less well studied.

    Objective: To identify the influence of metropolitan versus non-metropolitan residence on the relationship between disease severity and HR-QoL in patients with occupational hand eczema.

    Methods: The city of Copenhagen and the rest of Zealand were defined as metropolitan and non-metropolitan areas, respectively. Read More

    Pathophysiology and Management of Mild to Moderate Pediatric Atopic Dermatitis.
    J Pediatr Health Care 2018 Mar - Apr;32(2):S2-S12
    Atopic dermatitis (AD), or eczema, is a chronic inflammatory skin condition characterized by relapsing pruritic and dry, scaly lesions. AD affects 10% to 20% of children in the United States and significantly affects the quality of life of patients and their families. Primary care providers (PCPs) are often the first point of contact for the management of AD symptoms. Read More

    A Nonsteroidal Novel Formulation Targeting Inflammatory and Pruritus-Related Mediators Modulates Experimental Allergic Contact Dermatitis.
    Dermatol Ther (Heidelb) 2018 Feb 16. Epub 2018 Feb 16.
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
    Introduction: A major clinical challenge in treating allergic contact dermatitis (ACD) is that the first line of treatment is based on the use of corticosteroids. In this study, we aimed to develop a formulation that is devoid of steroids.

    Methods: We used mouse ears treated with dinitrofluorobenzene (DNFB) to induce ACD. Read More

    National survey of patch testing in the United Kingdom and Republic of Ireland: what proportion of the population is and should be tested?
    Contact Dermatitis 2018 Feb 14. Epub 2018 Feb 14.
    Department of Dermatology, Singleton Hospital, Swansea SA2 8QA, UK.
    Background: An initial study of patch testing practices across Wales, United Kingdom, showed wide variation in practice against a standardized set of guidelines and best practice recommendations.

    Objectives: To evaluate (i) current patch testing practice on a national level in the United Kingdom and Republic of Ireland (ROI), (ii) compliance with the current published guidelines, and (iii) the proportion of the catchment population tested by patch testing centres.

    Methods: In consultation with the British Association of Dermatologists and British Society for Cutaneous Allergy, proformas addressing clinical guidelines and best practice recommendations were sent to all dermatology units in the United Kingdom and ROI. Read More

    Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data.
    Drug Des Devel Ther 2018 31;12:241-254. Epub 2018 Jan 31.
    Department of Hematology/Oncology, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC, USA.
    Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. Read More


    Are Senna based laxatives safe when used as long term treatment for constipation in children?
    J Pediatr Surg 2018 Jan 31. Epub 2018 Jan 31.
    Center for Colorectal and Pelvic Reconstruction, Nationwide Children's Hospital, Columbus, OH, United States.
    Background And Aim: Senna is a stimulant laxative commonly used by pediatricians, pediatric gastroenterologists, and pediatric surgeons. Many clinicians avoid Senna for reasons such as tolerance or side effects but this has little scientific justification. We recently found several patients we were caring for developed perineal blistering during the course of Senna treatment. Read More

    The expression and function of galectins in skin physiology and pathology.
    Exp Dermatol 2018 Feb 10. Epub 2018 Feb 10.
    Institute of Biomedical Sciences, Academia Sinica, Taiwan.
    The galectin family comprises β-galactoside-binding proteins widely expressed in many organisms. There are at least 16 family members, which can be classified into three groups based on their carbohydrate-recognition domains. Pleiotropic functions of different galectins in physiological and pathological processes through extracellular or intracellular actions have been revealed. Read More

    Efficacy and Safety of Guselkumab, an Anti-interleukin 23 Monoclonal Antibody, for Palmoplantar Pustulosis: A Randomized Clinical Trial.
    JAMA Dermatol 2018 Feb 7. Epub 2018 Feb 7.
    Janssen Pharmaceutical K.K., Tokyo, Japan.
    Importance: Palmoplantar pustulosis (PPP) is a recalcitrant skin disease with no biologics currently approved for treatment. The involvement of interleukin 23 (IL-23) and cytokines of the type 17 helper T cell lineage in the pathogenesis of PPP has been recently postulated.

    Objective: To evaluate the efficacy and safety of guselkumab, an anti-IL-23 monoclonal antibody, in Japanese patients with PPP. Read More

    Signs of atopic dermatitis and contact dermatitis affected by distinct H2-haplotype in the NC/Nga genetic background.
    Sci Rep 2018 Feb 7;8(1):2586. Epub 2018 Feb 7.
    Department of Veterinary Pathology, Nippon Veterinary and Life-science University (NVLU), Musashino, Japan.
    We recently advocated in favour of naming a novel H2-haplotype consisting of K, D/L, I-Aand I-Ein the atopic dermatitis (AD) mouse model NC/Nga as "H-2." The role of the H2-haplotype in AD development was investigated in H2-congenic NC/Nga mice (NC.h2and NC. Read More

    Involvement of the Negative Feedback of IL-33 Signaling in the Anti-Inflammatory Effect of Electro-acupuncture on Allergic Contact Dermatitis via Targeting MicroRNA-155 in Mast Cells.
    Inflammation 2018 Feb 5. Epub 2018 Feb 5.
    Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion, Hubei University of Chinese Medicine, 1 Huangjiahu West Road, Hongshan District, Wuhan, 430065, China.
    In this study, we aimed to investigate the effect of electro-acupuncture (EA) at the Zusanli acupoint (ST36) on interleukin (IL)-33-mediated mast cell activation. Firstly, 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD) in rats was developed with or without EA treatment. Then, rat peritoneal mast cells (RPMCs) were obtained and cultured in the presence of IL-33. Read More

    Occupational allergic contact dermatitis caused by antibiotics in healthcare workers - relationship with non-immediate drug eruptions.
    Contact Dermatitis 2018 Feb 5. Epub 2018 Feb 5.
    Dermatology Department, Coimbra Hospital and University Centre (CHUC), Praceta Prof. Mota Pinto, 3000-075, Coimbra, Portugal.
    Background: Occupational allergic contact dermatitis (ACD) in healthcare workers (HCWs) is common, but systemic antibiotics are rarely reported as the cause.

    Objectives: Characterize occupational ACD by handling systemic antibiotics.

    Method: A retrospective analysis was performed of ACD caused by systemic antibiotics among HCWs patch tested between 2010 and 2016 with a series of systemic antibiotics. Read More

    The Journal of Allergy and Clinical Immunology: In Practice 2017 Year in Review.
    J Allergy Clin Immunol Pract 2018 Jan 31. Epub 2018 Jan 31.
    Department of Allergy, Kaiser Permanente Southern California, San Diego, Calif.
    An impressive number of clinically impactful studies and reviews were published in The Journal of Allergy and Clinical Immunology: In Practice in 2017. As a service to our readers, the editors provide this Year in Review article to highlight and contextualize the advances published over the past year. We include information from articles on asthma, allergic rhinitis, rhinosinusitis, immunotherapy, atopic dermatitis, contact dermatitis, food allergy, anaphylaxis, drug hypersensitivity, urticarial/angioedema, eosinophilic disorders, and immunodeficiency. Read More

    Kumkum-induced allergic contact dermatitis: Are we missing the actual culprit?
    Indian J Dermatol Venereol Leprol 2018 ;84(2):153-156
    Department of Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
    Background: Kumkum, made with turmeric and slaked lime along with colour enhancing dyes is known to cause allergic contact dermatitis. The possible contact allergens in kumkum include turmeric, Sudan-1, 4-aminoazobenzene, brilliant lake red R and cananga oil. We report patch test results among patients with suspected contact hypersensitivity to kumkum. Read More

    Different concentrations and volumes of p-phenylenediamine in pet. (equivalent doses) are associated with similar patch test outcomes: a pilot study.
    Contact Dermatitis 2018 Feb 2. Epub 2018 Feb 2.
    Contact Dermatitis Institute, Phoenix, AZ 85008, USA.
    Background: Concern about causing active sensitization when patch testing is performed with p-phenylenediamine (PPD) 1% pet. has led to a recommendation to use PPD 0.3% pet. Read More

    Investigating the roles of regulatory T cells, mast cells and interleukin-9 in the control of skin inflammation by vitamin D.
    Arch Dermatol Res 2018 Feb 1. Epub 2018 Feb 1.
    Telethon Kids Institute, University of Western Australia, 100 Roberts Rd, Subiaco, Perth, WA, 6008, Australia.
    Topical application of biologically active vitamin D [1,25-dihydroxyvitamin D (1,25(OH)D)], or low-calcemic analogues, curb skin inflammation through mechanisms that involve migratory dendritic cells (DCs) and regulatory T (T) cells. 1,25(OH)D also promotes immunoregulation by mast cells, and inhibits the development of T helper type-9 (Th9) cells that secrete interleukin-9 (IL-9). Here, we investigated the ability of topical 1,25(OH)D to suppress contact dermatitis through an IL-9-dependent process, examining mast cells and IL-9-secreting T cells. Read More

    Systemic contact dermatitis due to corrosion of titanium-coated nickel and cobalt bone plate fixation: A case report.
    Medicine (Baltimore) 2017 Dec;96(50):e9120
    Division of Allergy and Immunology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
    Rationale: Corrosion refers to the degradation of a material that occurs following its interaction with other substances in the environment. Corrosion of metallic substances into tissues may lead to inflammatory responses such as systemic contact dermatitis (SCD), a skin condition where an individual who has previously been sensitized to a particular allergen via the cutaneous route will subsequently react to same allergen via the systemic route. This condition occurs following exposure to allergens such as metals, medications, and certain food substances. Read More

    [The application of the modern phototherapeutic technologies for the medical rehabilitation of the children].
    Vopr Kurortol Fizioter Lech Fiz Kult 2017 Dec 28;94(6):45-52. Epub 2017 Dec 28.
    Moscow Scientific and Practical Centre for Medical Rehabilitation, Restorative and Sports Medicine.
    This literature review is focused on the application of polychromatic and monochromatic polarized light for the treatment of various diseases of the childhood including those in the newborns and the premature babies. The analysis of the data of scientific research gives evidence of the beneficial effect of polychromatic polarized light on the clinical course of various skin diseases in the newborn children. Moreover, the improved immunological and reparative processes were revealed after the surgical interventions for congenital heart defects in the newborns. Read More

    Immunogenetics of cytokine genes in parthenium dermatitis: a review.
    Eur Ann Allergy Clin Immunol 2017 Nov 27. Epub 2017 Nov 27.
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
    Summary: Parthenium dermatitis is a chronic immuno-inflammatory, distressing skin disease and is mediated by activated T-lymphocyte which is primarily manifested on the exposed sites of the face, neck, hand and flexures. Parthenium hysterophorus is ubiquitous, hence it is diffi-cult to avoid the aero-allergenic antigen parthenin, responsible for the contact dermatitis. The pathogenesis of parthenium dermatitis is characterized by infiltration of T-lymphocytes into challenged skin sites and the development of a cutaneous inflammation due to altered regulatory network of pro and anti-inflammatory cytokines. Read More

    Early and Late Onset Side Effects of Photodynamic Therapy.
    Biomedicines 2018 Jan 29;6(1). Epub 2018 Jan 29.
    Section of Dermatology-Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
    Photodynamic Therapy (PDT) is a non-invasive treatment successfully used for neoplastic, inflammatory and infectious skin diseases. One of its strengths is represented by the high safety profile, even in elderly and/or immuno-depressed subjects. PDT, however, may induce early and late onset side effects. Read More

    Nickel hypersensitivity following closure of atrial septal defect: A case report and review of the literature.
    Australas J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.
    We present an unusual case where symptoms of headache and chest pain persisted for 3 years following the implantation of a septal occluder device for an atrial septal defect despite endothelialisation of the device. The patient was found to have nickel hypersensitivity on patch testing. Following the removal of the device the patient had complete resolution of headaches and chest pain up to 10 months post-explantation. Read More

    Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly.
    Arch Toxicol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Internal Medicine, Bundeswehr Hospital, Scharnhorststraße 13, 10115, Berlin, Germany.
    Allergic contact dermatitis is a widespread health disorder and occupational skin disease. Hence, screening for contact-sensitizing chemicals is highly relevant to toxicology, dermatology, and occupational medicine. The use of animal tests for this purpose is constrained by ethical considerations, need for high-throughput screening, and legislation (e. Read More

    Cutting Edge: Nqo1 Regulates Irritant Contact Hypersensitivity against Croton Oil through Maintenance of Dendritic Epidermal T Cells.
    J Immunol 2018 Mar 29;200(5):1555-1559. Epub 2018 Jan 29.
    Department of Immunology and Pathology, Research Institute, National Center for Global Health and Medicine, Ichikawa-shi, Chiba 272-8516, Japan
    Irritant contact dermatitis (ICD) is associated with local release of inflammatory mediators such as reactive oxygen species and regulated by various antioxidative enzymes and antioxidants. Although Nqo1 is involved in antioxidative reactions and detoxification, its role in ICD remains unknown. Nqo1-deficient mice exhibited augmented ear swelling accompanied by neutrophil infiltration in the croton oil-induced mouse ICD model. Read More

    Patch testing in facial dermatitis using Chinese Baseline Series (60 allergens) and Cosmetic Series (58 allergens).
    J Eur Acad Dermatol Venereol 2018 Jan 29. Epub 2018 Jan 29.
    Dermatology, Peking university people's hospital.
    Facial dermatitis (FD) is a common problem encountered in clinical practice. It effects patients' self-esteem and quality of life. Mild reactions such as itching, pricking, dryness can occur in more than 10% of patients[1]. Read More

    Impact of climate change on dermatological conditions related to flooding: update from the International Society of Dermatology Climate Change Committee.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Department of Dermatology, Mayo Clinic in Minnesota, Rochester, Minnesota, USA.
    Climate change contributes to the increase in severity and frequency of flooding, which is the most frequent and deadly disaster worldwide. Flood-related damage can be very severe and include health effects. Among those health impacts, dermatological diseases are one of the most frequently encountered. Read More

    In vivo efficacy and evaluation of gel-cream containing dehydrated betamethasone dipropionate nanocapsules.
    J Microencapsul 2018 Jan 29:1-34. Epub 2018 Jan 29.
    a Departament of Industrial Pharmacy , Federal University of Santa Maria , Santa Maria , Brazil.
    This study aimed to develop gel-creams from the lyophilised product of betamethasone dipropionate-loaded lipid-core nanocapsule suspensions and evaluated its efficacy in a model of contact dermatitis. The gel-creams were prepared and characterized followed by a study of in vitro drug penetration/permeation and its in vivo efficacy. The suspensions and lyophilised products showed nanometric size; the betamethasone content was 0. Read More

    Clinical profile of 300 men with facial hypermelanosis.
    J Dermatol Case Rep 2017 Dec 1;11(2):20-24. Epub 2017 Dec 1.
    Department of Dermatology, Venereology & Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda)-176001 (Himachal Pradesh), India.
    Background: Facial hypermelanosis is a significant cause of cosmetic disfigurement, social embarrassment and psychological morbidity affecting quality of life.

    Objective: To study clinicoepidemlogic patterns of facial hypermelanoses among men.

    Material And Methods: Medical records of all adult males presenting with facial hypermelanoses were analyzed for this retrospective cross sectional study for demographic details, duration, cosmetic usage, sun exposure, drug intake, infections, systemic or cutaneous diseases, and family history of hypermelanotic dermatosis. Read More

    Generalized reactions during skin testing with clindamycin in drug hypersensitivity: a report of 3 cases and review of the literature.
    Contact Dermatitis 2018 Jan 22. Epub 2018 Jan 22.
    Department of Dermatology and Allergy, Comprehensive Allergy Centre, Hannover Medical School, 30625, Hannover, Germany.
    Background: The diagnostic approach to drug hypersensitivity includes a detailed medical history, clinical examination, and skin testing and/or oral challenge with a culprit or alternative drug, depending on the type of reaction and the suspected drugs. Although skin testing is considered to be rather safe, cutaneous and systemic, including fatal, reactions have been described.

    Objectives: To report 3 cases with generalized delayed reactions after skin testing with clindamycin, and to review the existing literature. Read More

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