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    1 OF 729

    Hand eczema, atopic dermatitis and filaggrin mutations in adult Danes: a registry-based study assessing risk of disability pension.
    Contact Dermatitis 2017 Apr 20. Epub 2017 Apr 20.
    Department of Dermatology and Allergy, The National Allergy Research Centre, Copenhagen University Hospital Herlev-Gentofte, 2900, Hellerup, Denmark.
    Background: Atopic dermatitis and hand eczema often impair the ability of people to work. Only a few studies have investigated whether individuals with loss-of-function filaggrin gene (FLG) mutations, who often have severe and early onset of dermatitis, experience occupational consequences.

    Objective: To investigate the personal consequences of having atopic dermatitis and/or hand eczema and FLG mutations. Read More

    Garlic Dermatitis on the Neck of an Infant Treated for Nasal Congestion.
    Pediatr Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Division of Dermatology, Ann and Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    The health benefits of garlic (Allium sativum) as a naturopathic remedy have been well documented, but topical application of garlic has been linked to allergic and irritant contact dermatitis. We present a case of severe irritant contact dermatitis due to application of a fresh garlic necklace to the neck of infant for treatment of nasal congestion. Read More

    A multi-institutional joint study of contact dermatitis related to hair colouring and perming agents in Japan.
    Contact Dermatitis 2017 Apr 20. Epub 2017 Apr 20.
    Department of Dermatology, Fujita Health University School of Medicine, Toyoake, 470-1100, Japan.
    Background: In Japan, allergic contact dermatitis caused by hair colouring agents is a considerable problem for those occupationally exposed and also for consumers. Over the last 20 years, p-phenylenediamine (PPD) has been a common allergen, with ∼7% positive patch test reactions.

    Objectives: To investigate which ingredients caused allergic contact dermatitis related to hair dye and perming solutions in Japan, to assess whether PPD is suitable for screening for hair dye allergy, and to propose allergens for a Japanese hairdresser series. Read More

    An epidemic of allergic contact dermatitis caused by a new allergen, caprylhydroxamic acid, in moisturizers.
    Contact Dermatitis 2017 Apr 19. Epub 2017 Apr 19.
    Department of Dermatology and Allergy Centre, Tampere University Hospital, 33520, Tampere, Finland.
    Background: In 2016, dermatologists in Finland suspected contact allergy in several patients using moisturizers under the trade name Apobase®. Following a formulation change, Phenostat™, which is a mixture of phenoxyethanol, caprylhydroxamic acid, and methylpropanediol, was used as a preservative in Apobase® moisturizers in Finland.

    Objectives: To confirm the suspected contact allergy to Apobase® cream, oily cream, and/or lotion, and to identify the specific contact allergen and define its optimal patch test concentration. Read More

    Common Diaper Ingredient Questions: Modern Disposable Diaper Materials Are Safe and Extensively Tested.
    Clin Pediatr (Phila) 2017 May;56(5_suppl):23S-27S
    2 Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
    Today's disposable diapers are high-performance and well-tested products, designed to keep skin dry and healthy. They are primarily made of biologically inert polymers, commonly used in fabrics and other materials that are in contact with skin, and in foods and cosmetics. Still, product safety and ingredients in everyday products can be a source of anxiety for new parents. Read More

    Myths on Chemical Burns in the Diaper Area.
    Clin Pediatr (Phila) 2017 May;56(5_suppl):13S-15S
    1 Kenwood Dermatology, Cincinnati, OH, USA.
    Over the past several years, a number of articles and online posts have circulated on the Internet associating use of disposable and cloth diapers with chemical burns on babies' skin. Because both mild chemical burns and diaper dermatitis (diaper rash) can cause skin redness and peeling, it is not surprising that some confusion has arisen regarding the association between these two conditions. However, diapers cannot cause chemical burns because they are made of inert materials. Read More

    Differential Diagnosis of Diaper Dermatitis.
    Clin Pediatr (Phila) 2017 May;56(5_suppl):16S-22S
    1 Johns Hopkins Children's Center, Baltimore, MD, USA.
    Mild diaper dermatitis often occurs in children before toilet training is complete, particularly from 9 to 12 months of age, and the most common presentation is an irritant contact dermatitis. Diaper dermatitis may account for up to 25% of dermatology visits to health care providers during the first year of life. Fortunately, since the introduction of hypoallergenic, superabsorbent modern disposable diapers, the incidence and severity of irritant and allergic contact dermatitis has decreased dramatically. Read More

    Temporary Black Henna Tattoos and Sensitization to para-Phenylenediamine (PPD): Two Paediatric Case Reports and a Review of the Literature.
    Int J Environ Res Public Health 2017 Apr 14;14(4). Epub 2017 Apr 14.
    Pediatric Clinic, Università degli Studi di Perugia, 06129 Perugia, Italy.
    Background: The use of temporary henna tattoos has increased dramatically in recent years, especially in children and adolescents. To obtain a darker colour and prolong the life of the tattoo, red henna, a plant-derived substance, is typically added to para-phenylenediamine (PPD). The mixture is called temporary black henna tattoo (TBHT). Read More

    [Epicutaneous patch testing in delayed drug hypersensitivity reactions induced by antiepileptic drugs].
    Therapie 2017 Mar 25. Epub 2017 Mar 25.
    Centre régional de pharmacovigilance de Sfax, faculté de médecine de Sfax, avenue Majida-Boulila, 3029 Sfax, Tunisie.
    Introduction: Antiepileptic drugs are widely used and are associated with numerous side effects including skin eruptions. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to evaluate the profitability of epicutaneous tests in delayed hypersensitivity reactions induced by antiepileptic drugs. Read More

    Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling.
    Inflamm Res 2017 Apr 12. Epub 2017 Apr 12.
    Department of Physiology and Molecular Sciences, School of Pharmacy, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.
    Objectives: Contact dermatitis model involving repeated application of hapten is used as a tool to assess dermatitis, as characterized by thickening. Involvement of cell proliferation, elicited by repeated hapten-stimulation, in this swelling has been unclear. Curcumin is reported to reduce inflammation. Read More

    [Pruritus of the scalp : Simply pulling out your hair?]
    Hautarzt 2017 Apr 12. Epub 2017 Apr 12.
    Abteilung Klinische Sozialmedizin, Schwerpunkt: Berufs- und Umweltdermatologie, Universitätsklinikum, Ruprecht-Karls-Universität Heidelberg, Voßstr. 2, 69115, Heidelberg, Deutschland.
    Scalp pruritus is a frequent symptom and can be caused by dermatologic diseases, contact allergies, neurologic, psychiatric/somatoform and systemic diseases. In daily clinical practice scalp pruritus is a diagnostic and therapeutic challenge, especially if no detectable lesions are present. A detailed patient history and the inspection of scalp and the skin of the whole body are essential for diagnosis. Read More

    Chemokine Receptor CXCR3 in the Spinal Cord Contributes to Chronic Itch in Mice.
    Neurosci Bull 2017 Apr 11. Epub 2017 Apr 11.
    Pain Research Laboratory, Institute of Nautical Medicine, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226019, China.
    Recent studies have shown that the chemokine receptor CXCR3 and its ligand CXCL10 in the dorsal root ganglion mediate itch in experimental allergic contact dermatitis (ACD). CXCR3 in the spinal cord also contributes to the maintenance of neuropathic pain. However, whether spinal CXCR3 is involved in acute or chronic itch remains unclear. Read More

    Metals Are Important Contact Sensitizers: An Experience from Lithuania.
    Biomed Res Int 2017 16;2017:3964045. Epub 2017 Mar 16.
    Clinic of Infectious and Chest Diseases, Dermatovenereology and Allergology, Centre of Pulmonology and Allergology, Vilnius University, Vilnius, Lithuania.
    Background. Metals are very frequent sensitizers causing contact allergy and allergic contact dermatitis worldwide; up-to-date data based on patch test results has proved useful for the identification of a problem. Objectives. Read More

    Hypersensitivity reactions due to black henna tattoos and their components: are the clinical pictures related to the immune pathomechanism?
    Clin Mol Allergy 2017 10;15. Epub 2017 Apr 10.
    Section of Allergy and Clinical Immunology, Department of Internal Medicine and Infectious Diseases, University of Bari Medical School, Bari, Italy.
    Hypersensitivity to para-phenylenediamine (PPD) and related compounds induced by temporary black henna tattoos has become a serious health problem worldwide. Different patterns of sensitization with various clinical aspects are described in literature due to PPD associated to henna tattoo and these manifestations are likely correlated with the immunological and dermatological pathomechanisms involved. Henna is the Persian name of the plant Lawsonia inermis, Fam. Read More

    Effect of intravenous pulse dexamethasone versus daily oral prednisolone on bone mineral density in dermatology patients: Is it a site-specific response?
    Indian J Dermatol Venereol Leprol 2017 Apr 10. Epub 2017 Apr 10.
    Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: The use of glucocorticoids in various forms of administration is complicated by their systemic side effects. Although intravenous pulse therapy is considered to have lesser systemic side effects, there are few studies in literature comparing the effects of intravenous pulse glucocorticoids versus oral daily glucocorticoids on bone mineral density.

    Aim: To compare the effects of intravenous pulse glucocorticoids and oral daily glucocorticoids on bone mineral density with the aim of finding any site-specific osteopenic side effect. Read More

    [Allergic contact dermatitis of the scalp].
    Hautarzt 2017 Apr 10. Epub 2017 Apr 10.
    Univ. Klinik für Dermatologie und Venerologie, Medizinische Universität Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.
    Contact allergy represents an important differential diagnosis to other skin diseases of the scalp. The typical efflorescences, spreading in the periphery, pruritus, and the clinical history support the differential diagnosis. Since the scalp is particularly resistant to contact dermatitis, allergens applied to this area often produce dermatitis of the eyelids, ears and neck. Read More

    Survey of Occupational Allergic Contact Dermatitis and Patch Test among Clothing Employees in Beijing.
    Biomed Res Int 2017 15;2017:3102358. Epub 2017 Mar 15.
    Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
    Occupational population-based epidemiological data relating to occupational contact allergies in the Chinese clothing industry are limited. To investigate the prevalence of occupational allergic contact dermatitis (OACD) and to identify the causative allergens among clothing employees in China, a cross-sectional study was conducted in 529 clothing employees at 12 clothing factories in Beijing. All employees were subjected to an interview using self-administered questionnaire and skin examination, and those who were diagnosed with occupational contact dermatitis (OCD) were patch tested. Read More

    Surgery-Related Contact Dermatitis: A Review of Potential Irritants and Allergens.
    J Allergy Clin Immunol Pract 2017 Apr 7. Epub 2017 Apr 7.
    Division of Allergy, Asthma and Immunology, Scripps Clinic, San Diego, Calif.
    Surgical procedures utilize an increasing number of medical products including antiseptics, anesthetics, gloves, suture materials, tissue adhesives, topical antibiotics, and bandages. Many of these products have irritant potential. Allergic contact dermatitis has also been reported. Read More

    Occupational Contact Dermatitis in North American Production Workers Referred for Patch Testing: Retrospective Analysis of Cross-sectional Data From the North American Contact Dermatitis Group 1998 to 2014.
    Dermatitis 2017 Apr 7. Epub 2017 Apr 7.
    From the *HCMC Parkside Occupational and Contact Dermatitis Clinic; †Department of Dermatology, Minneapolis Veterans Affairs Medical Center; and ‡Department of Dermatology, University of Minnesota Medical School, Minneapolis, MN; §Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; ∥Dartmouth-Hitchcock Medical Center, Lebanon, NH; ¶Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada; #Department of Dermatology, Columbia University, New York, NY; **Ohio State University, Columbus; ††University of Louisville, KY; ‡‡Department of Dermatology, Cleveland Clinic, OH; §§Associates in Dermatology, Fort Myers, FL; ∥∥Department of Dermatology, Keck School of Medicine at University of Southern California, Los Angeles; ¶¶Department of Dermatology, Pennsylvania State University, State College; ##Division of Dermatology, University of Ottawa, Ontario, Canada; ***Department of Dermatology, University of California, San Francisco; and †††Department of Dermatology, University of Cincinnati, OH.
    Background: Little is known about the epidemiology of contact dermatitis in production workers (PWs).

    Objective: The aims of this study were to estimate the prevalence of contact dermatitis and characterize clinically relevant and occupationally related allergens among North American PWs undergoing patch testing.

    Methods: This was a retrospective cross-sectional analysis of North American Contact Dermatitis Group data from 1998 to 2014. Read More

    Acta Clin Croat 2016 06;55(2):293-300
    Since the working medical personnel including dentists and dental technicians mainly use their hands, it is understandable that the most common occupational disease amongst medical personnel is contact dermatitis (CD) (80%-90% of cases). Development of occupational CD is caused by contact of the skin with various substances in occupational environment. Occupational etiologic factors for dental personnel are foremost reactions to gloves containing latex, followed by various dental materials (e. Read More

    Urticarial Dermatitis: Clinical Characteristics of Itch and Therapeutic Response to Cyclosporine.
    Ann Dermatol 2017 Apr 24;29(2):143-148. Epub 2017 Mar 24.
    Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.; Bio-Medical Research Institute, Pusan National University Hospital, Busan, Korea.
    Background: Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life.

    Objective: The objective of this study is to characterize the clinical patterns of pruritus in patients with urticarial dermatitis and to determine the effectiveness of cyclosporine treatment. Read More

    Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis.
    J Am Acad Dermatol 2017 Apr 6. Epub 2017 Apr 6.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Background: It is unclear whether patients with atopic dermatitis (AD) have an altered prevalence or risk for contact sensitization. Increased exposure to chemicals in topical products together with impaired skin barrier function suggest a higher risk, whereas the immune profile suggests a lower risk.

    Objective: To perform a systematic review and meta-analysis of the association between AD and contact sensitization. Read More

    [Skin and mucosal diseases in musicians].
    Ann Dermatol Venereol 2017 Apr 6. Epub 2017 Apr 6.
    University of Helsinki and Helsinki University Central Hospital, Departments of Dermatology, Allergology and Venereology, Meilahdentie 2, PO Box 160, 00029 Hus, Finlande. Electronic address:
    Whether they are professional or amateur, musicians are exposed to a various number of complications in relation to their practice, including cutaneous ones. The latter are often a simple musical stigma and a reason for pride for the musician. If they are symptomatic and disturb the musician, they have to be treated and prevented. Read More

    Nickel allergy in a Danish population 25 years after the first nickel regulation.
    Contact Dermatitis 2017 Apr 7. Epub 2017 Apr 7.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Background: Nickel in metallic items has been regulated in Denmark since 1990; however, 10% of young Danish women are still sensitized to nickel. There is a need for continuous surveillance of the effect of regulation.

    Objectives: To identify current self-reported metallic exposures leading to dermatitis in nickel-allergic patients, and the minimum contact time needed for dermatitis to occur. Read More

    Stratum corneum profiles of inflammatory mediators in patch test reactions to common contact allergens and sodium lauryl sulfate.
    Br J Dermatol 2016 Nov 4. Epub 2016 Nov 4.
    Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, the Netherlands.
    Background: Recent studies have demonstrated allergen-specific differences in the gene expression of inflammatory mediators in patch tested skin.

    Objectives: To determine levels of various inflammatory mediators in the stratum corneum (SC) after patch testing with common contact allergens and the skin irritant sodium lauryl sulfate (SLS).

    Methods: In total, 27 individuals who had previously patch tested positive to nickel, chromium, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) or para-phenylenediamine were retested and then patch tested with SLS and petrolatum, with petrolatum serving as the patch test control. Read More

    Mixed contact methods to improve response to a postal questionnaire.
    Occup Med (Lond) 2017 Mar 24. Epub 2017 Mar 24.
    Occupational Health Service, Guy's & St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
    Background: Postal questionnaires remain an important method of collecting data in trials. However, a high non-response rate can lead to biases, which may undermine the validity of the study.

    Aims: To assess a simple method of trying to improve response rates in an occupational health trial evaluating an intervention to prevent hand dermatitis in nurses. Read More

    Association between Skin Condition and Sleep Efficiency in Japanese Young Adults.
    J Nutr Sci Vitaminol (Tokyo) 2017 ;63(1):15-20
    Faculty of Food and Nutritional Sciences, Toyo University.
    There has been little epidemiological evidence that has comprehensively clarified whether alterations in lifestyle, such as sleep quality and dietary intake, explain changes in the skin condition of healthy young adults. Therefore, the aim of our study was to elucidate the association between skin condition and lifestyle behaviors such as diet and sleep, after statistically controlling confounding factors. The subjects were 54 participants who were aged 20-32 y, and who attended college in the Kanto region (in Japan). Read More

    Cutan Ocul Toxicol 2017 Apr 2:1-13. Epub 2017 Apr 2.
    c Near East University, Department of Dermatology , Nicosia , Cyprus.
    Objective: Various foods play important role in the pathogenesis of gastroesophageal reflux disease (GERD). These foods are shown to increase gastroesophageal reflux symptoms via various mechanisms and majority of these foods also contain nickel. The purpose of this study is to evaluate the relationship between Nickel sensitivity and GERD. Read More

    Hypersensitivity to Orthopedic Implants: A Review of the Literature.
    Rheumatol Ther 2017 Mar 31. Epub 2017 Mar 31.
    Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown University, Providence, RI, USA.
    Awareness of rare etiologies for implant failure is becoming increasingly important. In addition to the overall increase in joint arthroplasties, revision surgeries are projected to increase dramatically in the coming years, with volume increasing up to seven-fold between 2005 and 2030. The literature regarding the relationship between metal allergy and implant failure is controversial. Read More

    Case report: acute facial swelling in a recreational technical diver.
    Physiol Rep 2017 Apr;5(7)
    Divers Alert Network, Durham, North Carolina.
    A recreational scuba diver wore a second scuba regulator against his face during a scuba dive, attached by an elastic rubber cord necklace. After surfacing, the diver's left face became swollen. Through a process of elimination all other items of scuba equipment were excluded as potential causes. Read More

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