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    1 OF 736

    Primary photosensitization and contact dermatitis caused by Malachra fasciata Jacq. N.V. (Malvaceae) in sheep.
    Toxicon 2017 Sep 14;138:184-187. Epub 2017 Sep 14.
    Postgraduate Program in Animal Science, Universidade Federal da Paraíba, Areia, Paraíba, 58397-000, Brazil; Veterinary Hospital, Universidade Federal da Paraíba, Areia, Paraíba, 58397-000, Brazil. Electronic address:
    Farmers from Paraiba state, Northeast Brazil, claim that Malachra fasciata causes cutaneous lesions in sheep. To test its toxicity the plant was harvested daily and fed ad libitum for 21 days to 3 sheep as the sole food source (# 1-3). An additional sheep (# 4) was maintained as a control. Read More

    Recalcitrant chronic leg ulcer: An indication for patch testing for hydrocolloid dressing.
    J Am Acad Dermatol 2017 Oct;77(4):e97-e98
    Department of Dermatology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

    Mucocutaneous Inflammation in the Ikaros Family Zinc Finger 1 (IKZF1) - keratin 5 specifc transgenic mice.
    Allergy 2017 Sep 15. Epub 2017 Sep 15.
    Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Background: Our genome-wide association study documented an association between cold medicine related Stevens-Johnson syndrome / toxic epidermal necrolysis (CM-SJS/TEN) and Ikaros Family Zinc Finger 1 (IKZF1). Few studies examined biological and pathological functions of IKZF1 in mucosal immunity. We hypothesized that IKZF1 contributes to the mucocutaneous inflammation. Read More

    Hormonal contraception and the development of autoimmunity: A review of the literature.
    Linacre Q 2017 Aug 18;84(3):275-295. Epub 2017 Aug 18.
    BriaCell Therapeutics Corporation, Havertown, PA, USA.
    Estrogens and progestins are known to have profound effects on the immune system and may modulate the susceptibility to autoimmune diseases. A comprehensive literature search was carried out using PubMed for any of 153 autoimmune disease terms and the terms contraception, contraceptive, or their chemical components with limits of Humans + Title or Abstract. Over 1,800 titles were returned and scanned, 352 papers retrieved and reviewed in depth and an additional 70 papers retrieved from the bibliographies. Read More

    Bullous cutaneous larva migrans: case series and review of atypical clinical presentations.
    G Ital Dermatol Venereol 2017 Oct;152(5):516-519
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
    Hookworm-related cutaneous larva migrans (HRCLM) is caused by the penetration and migration in the epidermis of larvae of Ancylostoma braziliense and Ancylostoma caninum. It is characterized by slightly raised and erythematous tracks, located especially on the feet. These tracks may be single or multiple, serpiginous or linear, ramified and intertwined, accompanied by pruritus. Read More

    Atopic dermatitis: addressing allergy, infection, itch and complementary therapies.
    Semin Cutan Med Surg 2017 Sep;36(3):112-117
    Department of Medicine, State University of New York at Stony Brook, NY; Allergy & Immunology Training Program, Winthrop University Hospital, Mineola, New York, USA.
    Atopic dermatitis (AD) is a complex condition that results from the dynamic interplay between genetic predisposition, skin barrier defects, environmental factors, and a dysfunctional immune system. As a result, AD can be complicated by irritant and allergic contact dermatitis and imbalances in the skin microbiome, which can subsequently exacerbate the severity and complicate the course of preexisting atopic disease. Itch is an important symptom of AD, as it plays a large role in the quality of life of patients and their families. Read More

    9-cis-Retinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed-type allergy.
    Contact Dermatitis 2017 Sep 12. Epub 2017 Sep 12.
    Department of Dermatology and Allergy, University of Ulm, 89081, Ulm, Germany.
    Background: Hand eczema, which is frequently caused by delayed-type allergy, is treated with 9-cis-retinoic acid (9cisRA). However, knowledge on how 9cisRA modulates skin immunity is sparse.

    Objective: As dendritic cells (DCs) are central in the pathogenesis of contact allergy, we investigated 9cisRA modulation of DC function in murine contact hypersensitivity (CHS). Read More

    Effects of Acupuncture on 1-chloro-2,4-dinitrochlorobenzene-induced Allergic Contact Dermatitis in Mice.
    J Acupunct Meridian Stud 2017 Aug 11;10(4):252-260. Epub 2017 Jul 11.
    Shandong Medicine Technician College, Tai'an, Shandong, China. Electronic address:
    Allergic contact dermatitis (ACD) is a chronic inflammatory skin disease. Topical corticosteroids are the first-line therapy for ACD despite their significant adverse effects. Acupuncture has been widely used in the treatment of various skin diseases, but its underlying mechanism remains unrevealed. Read More

    Screening for skin-sensitizing allergens among patients with clinically suspected allergic contact dermatitis.
    Saudi Med J 2017 Sep;38(9):922-927
    Department of Pathology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.
    Objectives: To detect common skin-sensitizing agents among patients experiencing allergic contact dermatitis (ACD). Methods: This was a retrospective study of 152 patients with clinically suspected ACD who underwent patch testing in an allergy clinic at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between January 2012 and February 2015. Of these patients, only 74 (48%) patients reacted to one or more contact allergens. Read More

    Caspase inhibitors: a review of recently patented compounds (2013-2015).
    Expert Opin Ther Pat 2017 Sep 8:1-13. Epub 2017 Sep 8.
    a Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine , Kyung Hee University , Seoul , South Korea.
    Introduction: Although many caspase inhibitors have been patented, caspase inhibitors have not entered the market due to their toxicity and poor pharmacokinetic profile. Areas covered: In this article, we review patents (2013-2015) for peptide and non-peptide caspase inhibitors and their compositions. Expert opinion: Noteworthy patents include a peptidic caspase-2 inhibitor for nasal administration and a peptidomimetic caspase-6 inhibitor that can be administered via several routes for the treatment of neurodegenerative diseases. Read More

    Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial.
    Dermatitis 2017 Sep/Oct;28(5):308-312
    From the Dermatology Clinic, University of Catania, Italy.
    Background: Contact immunotherapy with squaric acid dibutylester (SADBE) for cutaneous warts has been reported to be effective, although no controlled studies are available so far.

    Objective: The aim of this study was to evaluate the efficacy of SADBE on cutaneous warts by a randomized, double-blind, vehicle-controlled, clinical trial.

    Methods: Thirty-six patients were randomly assigned to SADBE (18 cases) or vehicle (18 cases) group. Read More

    Benzalkonium Chloride: An Irritant and Sensitizer.
    Dermatitis 2017 Sep 5. Epub 2017 Sep 5.
    From the *Tufts University School of Medicine and †Department of Dermatology, Brigham and Women's Hospital, Boston, MA.
    Background: Benzalkonium chloride (BAK) is a known irritant, and potentially cross-reacting quaternary ammonium compounds are commonly used as preservatives in personal care products.

    Objective: The aim of the study was to review positive reactions to BAK in 615 patients patch tested for suspected allergic contact dermatitis.

    Methods: A retrospective chart review was performed in 615 patients patch tested from June 2015 to October 2016. Read More

    Allergenic Ingredients in Hand Wet Wipes.
    Dermatitis 2017 Sep/Oct;28(5):329-330
    University of Minnesota School of Medicine, Minneapolis, Department of Dermatology, Minneapolis Veterans Affairs Medical Center, MN, HCMC Parkside Occupational and Contact Dermatitis Clinic, Minneapolis, MN Department of Dermatology, Minneapolis Veterans Affairs Medical Center, MN, HCMC Parkside Occupational and Contact Dermatitis Clinic, Minneapolis, MN, Department of Dermatology, University of Minnesota, Minneapolis.

    Contact Allergy to Hydroperoxides of Linalool and D-Limonene in a US Population.
    Dermatitis 2017 Sep/Oct;28(5):313-316
    From the *Duke University School of Medicine and Departments of †Biostatistics and Bioinformatics and ‡Dermatology, Duke University Medical Center, Durham, NC.
    Background: Linalool and D-limonene are common fragrance ingredients that readily oxidize on exposure to air. The resulting hydroperoxides of linalool and D-limonene have been shown to have high frequencies of positive patch test reactions in several European and international studies.

    Objective: The aim of the study was to investigate the prevalence of contact allergy to the hydroperoxides of linalool and D-limonene in a US population. Read More

    Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis.
    Artif Cells Nanomed Biotechnol 2017 Sep 8:1-12. Epub 2017 Sep 8.
    a Sinhgad College of Pharmacy , Pune , India.
    Irritant contact dermatitis (ICD) and hyperpigmentation are the problems associated with skin. Topical curcumin (CUR) although effective in hyperpigmentation and ICD, is a challenging molecule due to low-solubility. Encapsulation of CUR into solid lipid nanoparticles (SLNs) makes it amenable to topical dosing as their small size promotes its penetration into the skin. Read More

    Prediction of skin sensitization potency sub-categories using peptide reactivity data.
    Toxicol In Vitro 2017 Sep 4;45(Pt 1):134-145. Epub 2017 Sep 4.
    BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany. Electronic address:
    While the skin sensitization hazard of substances can already be identified using non-animal methods, the classification of potency sub-categories GHS-1A and 1B is still challenging. Potency can be measured by the dose at which an effect is observed; since the protein-adduct formation is determining the dose of the allergen in the skin, peptide reactivity was used to assess the potency. The Direct Peptide Reactivity Assay (DPRA; one concentration and reaction-time) did not sufficiently discriminate between sub-categories 1A and 1B (56% accuracy compared to LLNA data, n=124). Read More

    An Unusual Case of Contact Dermatitis.
    Skin Appendage Disord 2017 Aug 27;3(3):163-165. Epub 2017 Apr 27.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
    We report a case of acute psoriasiform contact dermatitis of the forehead and scalp related to the use of a low-laser light cap. The patient had a positive patch test to dimethylol dihydroxyethyleneurea (DMDE), methylisothiazolinone, kathon CG, and cobalt. We believe that DMDE in the fabric of the cap was responsible for the allergic contact dermatitis in this case as the lesions resolved with cessation of cap use. Read More

    Consumer Preferences, Product Characteristics, and Potentially Allergenic Ingredients in Best-Selling Moisturizers.
    JAMA Dermatol 2017 Sep 6. Epub 2017 Sep 6.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
    Importance: Because moisturizer use is critical for the prevention and treatment of numerous dermatological conditions, patients frequently request product recommendations from dermatologists.

    Objective: To determine the product performance characteristics and ingredients of best-selling moisturizers.

    Design And Setting: This cohort study involved publicly available data of the top 100 best-selling whole-body moisturizing products at 3 major online retailers (Amazon, Target, and Walmart). Read More

    A safety analysis of edaravone (MCI-186) during the first six cycles (24 weeks) of amyotrophic lateral sclerosis (ALS) therapy from the double-blind period in three randomized, placebo-controlled studies.
    Amyotroph Lateral Scler Frontotemporal Degener 2017 Oct;18(sup1):71-79
    b Mitsubishi Tanabe Pharma Corporation , Tokyo , Japan.
    Background: There continues to be a need for new therapies to treat ALS.

    Objective: Provide an overview of safety for edaravone in ALS patients during the first six cycles of treatment.

    Methods: Analysis was based on three randomised, placebo-controlled clinical trials. Read More

    Development and Significance of the E-surveillance System for Contact Allergies in Slovenia.
    Acta Dermatovenerol Croat 2017 Jul;25(2):91-98
    Aleksandra Dugonik, MD, Department of Dermatology and Venereology, University Medical Centre, Ljubljanska street 2, 2000 Maribor, Slovenia;
    This paper describes the development and significance of online systems for the collection and analysis of medical data (patch test results) with a web application. Modern digital tools greatly aid in collecting, combining, and preserving the data in a way that is friendly, undemanding and time-efficient for the dermatologist. Creating a central database for the results of patch testing provides a better picture of contact sensitivity and characteristics of allergic contact dermatitis in Slovenia. Read More

    Potential immunotoxic effects of trichloroethylene-induced IV allergic reaction in renal impairment.
    Cent Eur J Immunol 2017 8;42(2):140-149. Epub 2017 Aug 8.
    Institute of Dermatology, The Fifth affiliated Hospital of Xinjiang Medical University, China.
    Trichloroethylene (TCE) is known to induce allergic contact dermatitis and subsequent occupational medicamentosa-like dermatitis (OMLD) with multi-system injuries, including liver, kidney, and skin injuries. However, the mechanisms underlying immune system dysfunction that result in organ injury have not yet been clearly elucidated. In the present study, we measured the levels of secreted cytokines by effect or T cells in TCE-treated guinea pigs to better understand the contribution of allergic disorders in renal injuries. Read More

    Best practices, new perspectives and the perfect emollient: optimizing the management of contact dermatitis.
    J Dermatolog Treat 2017 Sep 19:1-11. Epub 2017 Sep 19.
    e Department of Dermatology , University of Kiel , Kiel , Germany.
    Contact dermatitis (CD) is caused by environmental agents, irritants, and allergens that penetrate the epidermis and lead to inflammation. An intact skin barrier prevents penetration and is important in maintaining healthy skin. Classical diagnosis of CD is made using the patch test, and traditional treatment strategies for CD promote skin barrier integrity and resolve the inflammatory component of the condition. Read More

    Differential Diagnosis of Palmoplantar Eczema in Psoriatico: Chronic Allergic Contact Dermatitis and/or Psoriasis?
    Acta Derm Venereol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Dermatology and Venereology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, DE-39120 Magdeburg, Germany.
    Differential diagnosis of palmoplantar non-pustular psoriasis and chronic allergic contact dermatitis (ACD) and the combination of these conditions, termed "eczema in psoriatico" (EIP), is difficult, especially in cases of isolated involvement. A blind re-evaluation of 63 archived formalin-fixed palmoplantar samples, previously diagnosed clinically as either psoriasis or chronic ACD, was performed. Samples were allocated to histopathological diagnoses of psoriasis, contact dermatitis or EIP. Read More

    Decoction of Dictamnus Dasycarpus Turcz. Root Bark Ameliorates Skin Lesions and Inhibits Inflammatory Reactions in Mice with Contact Dermatitis.
    Pharmacogn Mag 2017 Jul-Sep;13(51):483-487. Epub 2017 Jul 19.
    Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam, Korea.
    Background: The root bark of Dictamnus dasycarpus Turcz. (Dictamni Radicis Cortex) has been widely used to treat skin diseases in Korea, and its anti-inflammatory efficacies were recently reported.

    Objective: The paper aims to investigate the inhibitory effects of decoction of Dictamni Radicis Cortex (DDRC) in mice with contact dermatitis (CD). Read More

    [Hand eczema in children. Clinical and epidemiological study of the population referred to a tertiary hospital].
    An Pediatr (Barc) 2017 Aug 21. Epub 2017 Aug 21.
    Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.
    Introduction: Hand eczema is a frequent disease in adults. Diagnosing the cause of hand eczema is difficult due to different classifications. There is lack of evidence on hand eczema and its causes in children. Read More

    Contact dermatitis is an unrecognized problem in the construction industry: Comparison of four different assessment methods.
    Am J Ind Med 2017 Oct 18;60(10):879-888. Epub 2017 Aug 18.
    Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
    Background: A high contact dermatitis symptoms prevalence has been observed in Dutch construction workers.

    Methods: Contact dermatitis was diagnosed by an expert panel using questionnaire data and photographs of 751 subjects' hands. A subset was evaluated by two occupational physicians. Read More

    Health utilities for controlled and uncontrolled chronic hand eczema in healthcare employees.
    Contact Dermatitis 2017 Aug 22. Epub 2017 Aug 22.
    Centre of Evidence-Based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.
    Background: Health utilities provide a universally applicable method for measuring the relative preferences or values of specific health states. Health economic studies use health utilities to estimate disease burden and the cost-effectiveness of interventions. Chronic hand eczema (CHE) affects many individuals and adversely affects work productivity. Read More

    Polymorphic light eruption and IL-1 family members: any difference with allergic contact dermatitis?
    Photochem Photobiol Sci 2017 Sep;16(9):1471-1479
    Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana" University of Salerno, Italy.
    Polymorphic light eruption (PLE) is described as a delayed-type hypersensitivity reaction (DTHR) toward a de novo light-induced antigen, yet to be identified. In effect, the inflammatory pathways of PLE and allergic contact dermatitis (ACD) share common patterns in terms of the mediators involved from the innate and adaptive immune system participating in the DTHR. As we have previously highlighted the role of interleukin (IL)-1 family members in ACD, we hypothesised that the same mediators could have similar functions in PLE. Read More

    Characterizing the Diagnosis and Treatment of Allergic Contact Dermatitis to 2-Octyl Cyanoacrylate Used for Skin Closure in Elective Orthopedic Surgery.
    J Arthroplasty 2017 Jul 18. Epub 2017 Jul 18.
    Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: While studies have shown that postoperative wound complications can predispose to deep infection following orthopedic surgery, the best form of skin closure has not been elucidated. Furthermore, the unique risks and benefits of each type of wound closure have not been studied. The goal of this study is to present the diagnosis and treatment of patients with allergic contact dermatitis (ACD) from 2-octyl cyanoacrylate, a skin adhesive commonly used in wound closure. Read More

    The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation.
    J Dermatol Sci 2017 Aug 4. Epub 2017 Aug 4.
    Departments of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
    Background: Accumulating evidence suggests that Toll-like receptor (TLR)-3 signaling is involved in non-infectious immune and inflammatory reactions as well as in viral infections. The skin of patients with atopic dermatitis (AD) is often infected with virus and bacteria, leading to the aggravation of atopic symptoms. These findings suggest TLR3 signaling may be involved in the pathogenesis of AD, but the exact role of TLR3 in AD remains to be defined. Read More

    Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch.
    J Allergy Clin Immunol 2017 Aug 5. Epub 2017 Aug 5.
    Center for the Study of Itch, Department of Anesthesiology, Washington University School of Medicine, St Louis, Mo. Electronic address:
    Background: Chronic itch is a highly debilitating symptom that underlies many medical disorders with no universally effective treatments. Although unique neuronal signaling cascades in the sensory ganglia and spinal cord have been shown to critically promote the pathogenesis of chronic itch, the role of skin-associated cells remains poorly understood.

    Objective: We sought to examine the cutaneous mechanisms underlying transient receptor potential vanilloid 4 (TRPV4)-mediated allergic and nonallergic chronic itch. Read More

    Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor.
    Contact Dermatitis 2017 Aug 14. Epub 2017 Aug 14.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks.

    Objectives: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen.

    Patients And Methods: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. Read More

    Occupational contact urticaria and protein contact dermatitis: causes and concomitant airway diseases.
    Contact Dermatitis 2017 Aug 10. Epub 2017 Aug 10.
    Occupational Medicine, Finnish Institute of Occupational Health, 00251, Helsinki, Finland.
    Background: Contact urticaria (CU) and protein contact dermatitis (PCD) are mainly induced by an immediate, IgE-mediated immunological mechanism. Immediate sensitization is also linked to asthma and/or allergic rhinitis.

    Objectives: To report causes of work-induced CU and PCD, and to evaluate the occurrence of concomitant airway diseases. Read More

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