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    Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.
    Pharmacol Res Perspect 2017 Dec;5(6)
    GlaxoSmithKline, Collegeville, PA, USA.
    GSK2982772 is a highly selective inhibitor of receptor-interacting protein kinase 1 (RIPK1) being developed to treat chronic inflammatory diseases. This first-in-human study evaluated safety, tolerability, pharmacokinetics (PK), and exploratory pharmacodynamics (PD) of GSK2982772 administered orally to healthy male volunteers. This was a Phase I, randomized, placebo-controlled, double-blind study. Read More

    Children with atopic dermatitis may have unacknowledged contact allergies contributing to their skin symptoms.
    J Eur Acad Dermatol Venereol 2017 Dec 9. Epub 2017 Dec 9.
    Department of Dermatology and Venereology, Aarhus University Hospital.
    Background: Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in AD facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in children with atopic dermatitis.

    Objective: To determine the prevalence of contact allergy in Danish children with atopic dermatitis and explore the problem of unacknowledged allergies maintaining or aggravating the skin symptoms. Read More

    Gaps in Workplace Education For Prevention of Occupational Skin Disease.
    Ann Work Expo Health 2017 Dec 5. Epub 2017 Dec 5.
    Department of Occupational and Environmental Health, St Michael's Hospital, 30 Bond St, Toronto, ON M5B 1W8.
    Background: Occupational contact dermatitis (OCD) is a common occupational disease. Evidence suggests that education and training are effective prevention strategies. In spite of these known prevention strategies, workers continue to develop OCD. Read More

    Allergic contact dermatitis caused by topical herbal remedies: importance of patch testing with the patients' own products.
    Contact Dermatitis 2017 Dec 7. Epub 2017 Dec 7.
    Department of Dermatology, University Hospitals KU Leuven, 3000, Leuven, Belgium.
    Background: Natural ingredients have variable compositions, so their allergenic potencies may differ.

    Objectives: To retrospectively analyse subjects reacting to herbal remedies over the past 27 years, with the aim of (i) evaluating demographic characteristics and lesion locations, (ii) describing the frequencies of positive patch test reactions, (iii) identifing sensitization sources, and (iv) studying concomitant sensitivity.

    Patients And Methods: In total, 15980 patients were patch tested between 1990 and 2016 with the European baseline series and/or other series, product(s) used, and, whenever possible, the respective ingredients. Read More

    Manuka Honey: A Case Study of Severe Atopic Eczematous Dermatitis Reaction to Henna Tattoo.
    Plast Surg Nurs 2017 Oct/Dec;37(4):154-157
    Jeanine Harrison, MN, BScN, ACNP, RN-EC, NP, is a Medical Aesthetic Nurse Practitioner and a practice expert in PRP techniques for face and hair at TH Medical Aesthetics, Thornhill, Ontario, Canada.
    Many mainstream medications were derived from plants and originally utilized in patient management well prior to the extensive research and testing processes of current pharmaceutical standards. The evolution of therapeutic management within the pharmaceutical and skin care industry often uses synthetic processing of products with less of a focus on the natural ingredients from which they were originally derived. However, more recently there has been a shift in pharmacological management to include the therapeutic use of more holistic medicines and practices and thus a broadening of the uses of nontraditional medical treatment options. Read More

    Methotrexate use in allergic contact dermatitis: a retrospective study.
    Contact Dermatitis 2017 Dec 6. Epub 2017 Dec 6.
    Departments of Dermatology and Pathology, Saint Louis University, St Louis, MO, 63104, USA.
    Background: Methotrexate, a folate antimetabolite, is used to treat atopic dermatitis and psoriasis. Although methotrexate's therapeutic efficacy has been noted in the literature, there are few data on the efficacy of methotrexate treatment for allergic contact dermatitis.

    Objective: To evaluate the efficacy and tolerability of methotrexate in treating allergic contact dermatitis at a single institution, and also to assess methotrexate efficacy in patients with chronic, unavoidable allergen exposure. Read More

    Comparison of atopy patch testing to skin prick testing for diagnosing mite-induced atopic dermatitis: a systematic review and meta-analysis.
    Clin Transl Allergy 2017 29;7:41. Epub 2017 Nov 29.
    Department of Clinical Laboratory, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 at Qingyang Road, Wuxi, 214023 Jiangsu Province People's Republic of China.
    Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Read More

    Regulatory B cells induced by ultraviolet B through toll-like receptor 4 signalling contribute to the suppression of contact hypersensitivity responses in mice.
    Contact Dermatitis 2017 Dec 5. Epub 2017 Dec 5.
    Department of Dermatology and Venereology, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
    Background: Ultraviolet (UV) B irradiation is known to suppress contact hypersensitivity (CHS) responses in mouse models by suppressing immune responses. However, the cellular mechanisms responsible for UVB-induced systemic suppression remain unclear. Regulatory B cells have been reported to play an inhibitory role during CHS. Read More

    Pattern of Skin Diseases and Occupational Dermatoses in Veterinarians and Veterinary Workers of Kashmir.
    Indian Dermatol Online J 2017 Nov-Dec;8(6):449-453
    Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Jammu and Kashmir, India.
    Background: Across the globe, skin disorders represent a frequent occupational concern for many health professionals including veterinarians and there is a serious impact of skin diseases on their lives and careers. But little is known about the prevalence and distribution of skin diseases (especially occupational) within this important professional group across Asia, especially India.

    Materials And Methods: The study was a cross-sectional study carried out over a period of one year in which veterinarians and veterinary workers of Kashmir valley were screened for various skin diseases and occupational dermatoses. Read More

    Contact allergy: an update.
    G Ital Dermatol Venereol 2017 Dec 1. Epub 2017 Dec 1.
    Department of Pulmonology, Allergology, Rheumatology and Clinical Immunology, Children's Hospital Zagreb, Zagreb, Croatia.
    Contact allergies are common cause of eczema in all age groups and are one of the most common causes of occupational disability. Contact dermatitis can be divided into irritant and allergic contact dermatitis. Distinguishing between irritant and allergic triggers of contact dermatitis by clinical and histologic examinations can be challenging. Read More

    Diagnostic Tools to Use When We Suspect an Allergic Reaction to a Tattoo: A Proposal Based on Cases at Our Hospital.
    Actas Dermosifiliogr 2017 Nov 29. Epub 2017 Nov 29.
    Unidad de Alergia Cutánea, Servicio de Dermatología, Hospital General Universitario de Alicante - ISABIAL, Alicante, España.
    Introduction: Tattooing has become a popular practice in western countries, particularly among younger populations. Tattoos, however, can cause complications, such as infections, allergic or foreign-body reactions, and even systemic inflammatory responses.

    Patients And Methods: We conducted a retrospective study of all patients seen for tattoo-related complications at our skin allergy unit between January 2002 and December 2016. Read More

    A proposal to create an extension to the European baseline series.
    Contact Dermatitis 2017 Dec 1. Epub 2017 Dec 1.
    Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, 91054, Erlangen, Germany.
    Background: The current European baseline series consists of 30 allergens, and was last updated in 2015.

    Objectives: To use data from the European Surveillance System on Contact Allergies (ESSCA) to propose an extension to the European baseline series in response to changes in environmental exposures.

    Methods: Data from departmental and national extensions to the baseline series, together with some temporary additions from departments contributing to the ESSCA, were collated during 2013-2014. Read More

    Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey.
    Contact Dermatitis 2017 Nov 28. Epub 2017 Nov 28.
    Department of Dermatology and Venereology, İstanbul University, İstanbul Medical Faculty, 34093, Çapa-İstanbul, Turkey.
    Background: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmetic products. They are potential contact sensitizers, including low molecular weight PEGs in nitrofurazone preparations that are still widely used in Turkey.

    Objectives: To investigate the prevalence of allergic contact dermatitis caused by PEG and PG in a relatively large group of patients in Turkey. Read More

    Medical laboratory technician professional pathologies: a 2006-2016 literature review.
    Ann Biol Clin (Paris) 2017 Dec;75(6):664-672
    Laboratoire de biologie médicale, Hôpital d'instruction des armées, Clermont-Tonnerre, Brest, France.
    The trade of laboratory technician (TL) exposes to many risks to health, because of biological or chemical or physical exposures. But the TL occupation is constantly evolving, the techniques are constantly changing. The purpose of this article is to take stock of the occupational TL pathologies which were recently described in the literature. Read More

    Contact Dermatitis after Prescription of an Ophthalmic Ointment Containing Fradiomycin Sulfate: A Retrospective Database Study Using Japanese Health Insurance Claims Data.
    Drugs Real World Outcomes 2017 Nov 30. Epub 2017 Nov 30.
    Pfizer Japan Inc., 3-22-7 Yoyogi, Shibuya-ku, Tokyo, 151-8589, Japan.
    Background: Topical ointments containing fradiomycin sulfate, such as fradiomycin sulfate/methylprednisolone (F/M) and fradiomycin sulfate/betamethasone sodium phosphate (F/B), are known to cause allergic contact dermatitis (CD) in some patients, especially when used for the periocular region. F/M is commonly prescribed to patients for various conditions; however, there are no reports with respect to the incidence of CD caused by F/M in actual practice.

    Objective: The aim was to investigate the incidence of CD using a data-based retrospective cohort study. Read More

    Allergy to hypoallergenic nail polish: does this exist?
    An Bras Dermatol 2017 May-Jun;92(3):421-422
    College of Medical Sciences, Santa Casa de São Paulo - São Paulo (SP) Brazil.
    The main allergen responsible for contact dermatitis to nail polish is tosylamide-formaldehyde resin. The so-called hypoallergenic nail polishes are suposedly free of agents that commonly trigger reactions. The commercially available products and their compositions were studied. Read More

    A Non-Peptidic S100A9 Specific Ligand for Optical Imaging of Phagocyte Activity In Vivo.
    Mol Imaging Biol 2017 Nov 28. Epub 2017 Nov 28.
    European Institute for Molecular Imaging (EIMI), University of Münster, Waldeyerstr. 15, 48149, Münster, Germany.
    Purpose: Non-invasive assessment of inflammatory activity in the course of various diseases is a largely unmet clinical challenge. An early feature of inflammation is local secretion of the alarmin S100A8/A9 by activated phagocytes. We here evaluate a novel S100A9-targeted small molecule tracer Cy5. Read More

    Persistence of contact allergy: a retrospective analysis.
    Contact Dermatitis 2017 Nov 27. Epub 2017 Nov 27.
    Department of Dermatology, University Medical Centre Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands.
    Background: Studies have shown that not all positive patch test reactions are reproducible upon retesting, that is, persistent. Non-persistent reactions might represent initial false-positive reactions, meaning that patients might unnecessarily avoid allergens.

    Objectives: To investigate the occurrence of both persistent and non-persistent patch test reactions, to explore possible explanations, and to investigate whether allergen-specific differences exist. Read More

    Assessing the validity of self-reported history of rash caused by metal or jewellery.
    Contact Dermatitis 2017 Nov 27. Epub 2017 Nov 27.
    Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA.
    Background: The use of metal-containing bio-devices is becoming increasingly common. Self-reported history of dermatitis with metal exposure is not established as being predictive for metal allergy.

    Objectives: To assess the validity of two screening questions addressing metal allergy. Read More

    Imaging mass spectrometry for novel insights into contact allergy - a proof-of-concept study on nickel.
    Contact Dermatitis 2017 Nov 23. Epub 2017 Nov 23.
    Occupational Dermatology, Department of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, 413 45, Gothenburg, Sweden.
    Background: In spite of extensive regulation to limit exposure, nickel remains the main cause of contact allergy in the general population. More detailed knowledge on the skin uptake of haptens is required. So far, no method exists for the visualization of clinically relevant haptens and their distribution in the skin. Read More

    Allergic contact dermatitis caused by 2-ethyl cyanoacrylate contained in glucose sensor sets in two diabetic adults.
    Contact Dermatitis 2017 Dec;77(6):426-429
    Department of Dermatology, Cliniques Universitaires Saint-Luc & Pôle Pneumologie, ORL et Dermatologie Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, 1200 Brussels, Belgium.

    Hypersensitivity to Dental Composites and Resin-Bonding Agents.
    Dent Update 2016 Nov;43(9):836-8, 841-2
    Adverse reactions to dental materials are not an uncommon occurrence, although hypersensitivity has gained much renewed interest in light of public concerns over the safety of dental materials. Hypersensitivity can affect both patients and dental professionals and may manifest as either allergic contact dermatitis or stomatitis. Methacrylic monomers, such as MMA, EGDMA, TEGDMA and Bis-GMA, have been documented as causative allergens, however, little has been documented on the risk of such monomers in composites and bonding agents. Read More

    Skin care products can aggravate epidermal function: studies in a murine model suggest a pathogenic role in sensitive skin.
    Contact Dermatitis 2017 Nov 20. Epub 2017 Nov 20.
    Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, CA, USA.
    Background: Sensitive skin is defined as a spectrum of unpleasant sensations in response to a variety of stimuli. However, only some skin care products provoke cutaneous symptoms in individuals with sensitive skin. Hence, it would be useful to identify products that could provoke cutaneous symptoms in individuals with sensitive skin. Read More

    Classification of consumer products under the EU CLP Regulation: what to consider when caring for contact dermatitis patients.
    Contact Dermatitis 2017 Nov 17. Epub 2017 Nov 17.
    Department of Dermatology, University Hospital Jena, 07743, Jena, Germany.
    Possibly hazardous chemical substances and mixtures need to be clearly and correctly classified and labelled, in order for their hazards to be properly identified and communicated. As dermatologists may encounter cases of harm to patients induced by chemicals, such as chemical burns, and irritant and allergic contact dermatitis, it is essential for them to be aware of the EU CLP Regulation and its potential pitfalls. Manufacturers are required by CLP to classify their products according to the rules given in the CLP Regulation. Read More

    Clinical patterns of Compositae dermatitis in Danish monosensitized patients.
    Contact Dermatitis 2017 Nov 17. Epub 2017 Nov 17.
    Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, 5000, Odense C, Denmark.
    Background: Compositae dermatitis was originally described as airborne contact dermatitis. More recent studies have reported a wider clinical spectrum, but often in polysensitized patients.

    Objective: To evaluate the clinical features of patients sensitized to Compositae only. Read More

    Prevalence of medical adhesive-related skin injury at peripherally inserted central catheter insertion site in oncology patients.
    J Vasc Access 2017 Nov 8. Epub 2017 Nov 8.
    Department of Nursing, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi - China.
    Introduction: The aim of our study was to identify the prevalence and risk factors of medical adhesive-related skin injuries (MARSI) at peripherally inserted central catheters (PICC) insertion site in oncology patients.

    Methods: A cross-sectional observational study lasting two weeks was carried out in four inpatient departments. Skin assessment data and photographs of skin were collected during PICC maintenance. Read More

    Patch testing in Israeli children with suspected allergic contact dermatitis: A retrospective study and literature review.
    Pediatr Dermatol 2017 Nov 16. Epub 2017 Nov 16.
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background/objectives: Childhood allergic contact dermatitis is recognized as a significant clinical problem. The objective was to evaluate the rate of positive patch tests in Israeli children with clinically suspected allergic contact dermatitis, identify possible sex and age differences, compare results with those in Israeli adults, and review pediatric studies in the literature.

    Methods: The study sample included 343 children and adolescents (197 female, 146 male; 1-18 years of age, mean age 11. Read More

    Kitty Litter Dermatitis from-Bromo-2-Nitropropane-1,3-Diol.
    Skinmed 2017 1;15(5):389-390. Epub 2017 Oct 1.
    Department of Dermatology.
    70-year-old white man presented with a 6-week history of an acute pruritic eruption in the axillary vaults, inguinal folds, and central lumbar area. Due to the severity of the pruritus, the patient was evaluated in the emergency department. He was treated with intramuscular triamcinolone, oral fluconazole, clobetasol cream, and miconazole powder, which provided only minimal relief. Read More

    Two Cases of Lepromatous Leprosy from Exposure to Armadillos in Florida.
    Skinmed 2017 1;15(5):391-393. Epub 2017 Oct 1.
    Department of Dermatopathology, James A. Haley Veterans Hospital, Tampa, FL.
    The first patient was a 41-year-old white man who was referred to the dermatology clinic with a 2-year history of numerous erythematous, hypoesthetic, poorly demarcated papules and plaques present on the trunk, buttocks, and bilateral upper and lower extremities (Figures 1 and 2). The lesions had initially begun as localized erythematous plaques on the right flank, and were diagnosed and treated as cellulitis and allergic contact dermatitis by primary care on separate occasions, with no resolution and continued gradual but persistent spread. Read More

    Comparison of allergen responses based on the TRUE Test and IQ Chamber system in Korean patients.
    Eur J Dermatol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
    A comparison between responses to allergens based on the TRUE Test®(TT) and IQ® Chamber (IQC) in Europeans has been previously reported, however, no such study has been performed in Asians. To compare allergen responses using the TT and IQC (using the Korean standard series) in order to gather more information regarding the positive response rates for each allergen and the clinical value of IQC. Suspected contact dermatitis patients were enrolled and tested with 18 allergens using the TT and IQC. Read More

    Treatment of Cutaneous Pseudolymphoma: A Systematic Review.
    Acta Derm Venereol 2017 Nov 14. Epub 2017 Nov 14.
    Department of Dermatology, Jena University Hospital Erfurter Straße 35, DE-07743 Jena, Germany.
    Cutaneous pseudolymphoma (CPL) is a reactive polyclonal T- or B-cell lymphoproliferative process. CPL may appear as localized or disseminated skin lesions. While most cases of CPL are idiopathic, they may also occur as a response to, for example, contact dermatitis, arthropod reactions, and bacterial infections. Read More

    Piercing and Metal Sensitivity: Extended Analysis of the North American Contact Dermatitis Group Data, 2007-2014.
    Dermatitis 2017 Nov/Dec;28(6):333-341
    From the *Department of Dermatology, Minneapolis Veterans Affairs Medical Center, MN; †Department of Dermatology, University of Minnesota Medical School; and ‡University of Minnesota School of Medicine, Minneapolis; §Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; ∥Department of Dermatology, University of California, San Francisco, CA; ¶Department of Dermatology, Cleveland Clinic, OH; #Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada; **Department of Dermatology, Keck School of Medicine, Los Angeles, CA; ††University of Louisville, KY; ‡‡Dartmouth-Hitchcock Medical Center, Lebanon, NH; §§Ohio State University, Columbus; ∥∥Associates in Dermatology, Fort Myers, FL; ¶¶Department of Dermatology, Pennsylvania State University, State College; ##Division of Dermatology, University of Ottawa, Ontario, Canada; and ***Department of Dermatology, University of Cincinnati, OH.
    Background: Body piercing provides a unique route of metal exposure.

    Objective: The aim of this study was to update previous analyses using the North American Contact Dermatitis Group data comparing pierced and unpierced individuals.

    Methods: This was a retrospective cross-sectional analysis of 17,912 patients patch tested by the North American Contact Dermatitis Group from 2007 to 2014 for demographics, positive reactions to metals (nickel, cobalt, chromium), and detailed analysis of nickel reactions by age, sex, and source of exposure. Read More

    Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation.
    Free Radic Biol Med 2017 Nov 10;115:31-42. Epub 2017 Nov 10.
    Departments of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. USA; Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. USA.
    Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Read More

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