Search our Database of Scientific Publications and Authors

I’m looking for a

    36669 results match your criteria Dermatitis Contact

    1 OF 734

    Patch testing in non-immediate cutaneous adverse drug reactions: value of extemporaneous patch tests.
    Contact Dermatitis 2017 Jul 21. Epub 2017 Jul 21.
    Department of Dermatology, Referral Centre for Toxic Bullous Diseases, AP-HP, Hôpital Henri-Mondor, UPEC, 94010, Créteil, France.
    Background: Patch testing following a standardized protocol is reliable for identifying the culprit drug in cutaneous adverse drug reactions (CADRs). However, these patch tests (PTs) require pharmaceutical material and staff, which are not always easily available.

    Objectives: To evaluate an extemporaneous PT method in CADRs. Read More

    Dermatitis of the Foot: Epidemiologic and Clinical Features in 389 Children.
    Pediatr Dermatol 2017 Jul 21. Epub 2017 Jul 21.
    Dermatology Department, Valencia University General Hospital, Valencia, Spain.
    Background/objectives: Footwear dermatitis is a form of contact dermatitis resulting from exposure to shoes. There have been only small studies regarding foot contact dermatitis in children. The present study was undertaken to define the prevalence and epidemiologic and clinical features of shoe dermatitis in children. Read More

    Prevalence of nickel allergy in Europe following the EU Nickel Directive - a review.
    Contact Dermatitis 2017 Jul 21. Epub 2017 Jul 21.
    Department of Dermatology and Allergy, National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Nickel contact allergy remains a problem in EU countries, despite the EU Nickel Directive. To study the prevalence of nickel allergy in EU countries following the implementation of the EU Nickel Directive, we performed a systematic search in PubMed for studies that examined the prevalence of nickel allergy in EU countries published during 2005-2016. We identified 46 studies: 10 in the general population and 36 in patch tested dermatitis patients. Read More

    [Diseases affecting the scalp].
    Cas Lek Cesk 2017 ;156(3):137-140
    The skin of the scalp differs from the skin on the other areas of the body because of a higher density of hair follicles and higher sebum production. These, together with the presence of hair, provide a suitable environment for superficial infections, infestations and inflammatory diseases. The good condition of the scalp has a significant impact on the patient's mental well-being and social interaction. Read More

    Allergic Contact Dermatitis From Methylisothiazolinone in Residential Wall Paint.
    Dermatitis 2017 Jul/Aug;28(4):284-287
    From the *Department of Dermatology, University of Minnesota Medical School; †HCMC Parkside Occupational and Contact Dermatitis Clinic; and ‡Minneapolis Veterans Affairs Medical Center, Department of Dermatology, Minneapolis, MN; and §Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
    A 33-year-old woman presented to our clinic for suspected photoallergic contact dermatitis with a recent episode of severe, vesicular dermatitis involving exposed skin and correlating with relocation to a new home. Biopsy results showed spongiotic and lichenoid dermatitis with eosinophils. Patch test results showed a very strong (+++) reaction to methylisothiazolinone (MI), mild (+) reaction to MI/methylchloroisothiazolinone, and no reaction to benzisothiazolinone. Read More

    Delayed Patch-Test Reading After 5 Days: An Update From the Mayo Clinic Contact Dermatitis Group.
    Dermatitis 2017 Jul/Aug;28(4):253-260
    From the *Mayo Clinic School of Medicine, Mayo Clinic College of Medicine and Science; and †Division of Clinical Dermatology, Mayo Clinic, Rochester, MN; ‡Department of Dermatology, Mayo Clinic, Jacksonville, FL; §Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN; and ∥Division of Clinical Dermatology, Mayo Clinic, Scottsdale, AZ.
    Background: Patch-test readings after day 5 have previously been used to identify delayed reactions to metals and topical antibiotics.

    Objective: The aims of this study were to identify allergens for which late readings (beyond day 5) would be most valuable and to compare our results with our previous study on delayed patch-test readings.

    Methods: This was a retrospective study of 298 patients who underwent metal and corticosteroid series patch testing from January 1, 2007, through December 31, 2013. Read More

    Contact Sensitization to Allergens in Nail Cosmetics.
    Dermatitis 2017 Jul/Aug;28(4):231-240
    From the *Icahn School of Medicine at Mount Sinai; and †Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York.
    Ingredients found in the nail cosmetic industry, including but not limited to methacrylate and acrylate monomers, formaldehyde, and toluene sulfonamide-formaldehyde resin, can incite allergic contact dermatitis. An eczematous outbreak presents on areas surrounding the nail plate and may spread through contact transfer of the allergen, commonly to the face and neck. Even components that were originally deemed nonsensitizing, such as the ubiquitous cyanoacrylate adhesive family, have been found to be allergenic. Read More

    Contact dermatitis considerations in atopic dermatitis.
    Clin Dermatol 2017 Jul - Aug;35(4):367-374. Epub 2017 Apr 22.
    Department of Dermatology, Loma Linda University, Loma Linda, CA. Electronic address:
    Complex immunologic pathways, influenced by both genetic and environment triggers, contribute to the development of atopic dermatitis and allergic contact dermatitis. Suppressing mechanisms between the Th1-driven allergic contact dermatitis and the Th2-driven atopic dermatitis conditions were thought to reduce the simultaneous expression of both; however, recent evidence indicates that pediatric patients with atopic dermatitis are likely to develop clinically relevant positive patch tests and more likely to react to specific allergens, such as lanolin. We review the potential role of skin barrier defects, such as filaggrin mutations and impaired barrier function, including aberrancies in epidermal pH buffering capabilities, which may promote bacterial biofilms and create an environment favoring sensitization. Read More

    In vitro effects of nickel on healthy non allergic peripheral blood mononuclear cells. The role of red grape polyphenols.
    Endocr Metab Immune Disord Drug Targets 2017 Jul 13. Epub 2017 Jul 13.
    Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, School of Medicine, Bari. Italy.
    Background: Nickel (Ni) is widely distributed in the environment and continuous exposure to this metal may lead to pathological manifestations, such as the human allergic contact dermatitis.

    Methods: The in vitro effects of Ni on human healthy non allergic peripheral blood mononuclear cells (PBMCs) in the absence or presence of red grape polyphenols have been evaluated. In the culture supernatants, levels of cytokines have been determined by ELISA, while nitric oxide (NO) concentration has been evaluated by a colorimetric procedure. Read More

    A Case of Ischemia-Induced Perianal Ulceration Mimicking Pyoderma Gangrenosum.
    Skinmed 2017 1;15(3):235-237. Epub 2017 Jun 1.
    Department of Dermatology, Antrim Area Hospital, Antrim, Northern Ireland.
    A 68-year-old woman, with a 75-pack-year smoking history and a history of chronic excess alcohol intake, presented with a 5-week history of worsening perianal pain and ulceration. She recently had an inpatient admission with back pain and urinary tract infection during which she developed diarrhea and fecal incontinence. Initially, the perianal ulceration was diagnosed as severe irritant contact dermatitis and treated with barrier creams and topical clobetasone 17-butyrate 0. Read More

    Identification of Unique Proteomic Signatures in Allergic and Non-Allergic Skin Disease.
    Clin Exp Allergy 2017 Jul 13. Epub 2017 Jul 13.
    MedImmune, LLC, Gaithersburg, MD, 20878.
    Background: Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC).

    Objective: Identify unique proteomic signatures to distinguish between inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation. Read More

    Tlx3 Function in the Dorsal Root Ganglion is Pivotal to Itch and Pain Sensations.
    Front Mol Neurosci 2017 28;10:205. Epub 2017 Jun 28.
    Beijing Institute of BiotechnologyBeijing, China.
    Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Here, our RNAseq and in situ hybridization data show that the transcription factor Tlx3 is required for the expression of a majority of itch-related molecules in the dorsal root ganglion (DRG). Read More

    Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata.
    Open Access Maced J Med Sci 2017 Jun 11;5(3):305-309. Epub 2017 Jun 11.
    Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.

    Aim: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals. Read More

    Elevation of Circulating Th17/Th22 Cells Exposed to Low-Level Formaldehyde and Its Relevance to Formaldehyde-Induced Occupational Allergic Contact Dermatitis.
    J Occup Environ Med 2017 Jul 10. Epub 2017 Jul 10.
    Department of Prevention and Healthcare, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China (Dr Mai, Su); Department of General Surgery, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China (Mr Liu); Department of Laboratory Science, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China (Ms Zhou); and Department of Dermatology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China (Mr Wen, Mr Lu).
    Objectives: The aim of this study was to investigate the effects of formaldehyde exposure on Th17 and Th22 cells and its relevance to human occupational allergic contact dermatitis (OACD).

    Methods: Circulating IL17-/IL22-secreting cells and serum IL17/IL22 levels in formaldehyde-exposed workers at Occupational Exposure Limit and nonexposed controls were assessed.

    Results: The IL17 and IL22 cell population were detected in both CD3CD8 and CD3CD8 cells. Read More

    Systemic contact dermatitis induced by roots of Hosta plantaginea.
    J Eur Acad Dermatol Venereol 2017 Jul 11. Epub 2017 Jul 11.
    Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea.
    In East Asia, herbs are not only used by traditional medical practitioners but also commonly eaten by public. Compositae and Rhus are well-known antigens that can cause allergic contact dermatitis, but the other herbs are not well studied for antigenicity. Hosta plantaginea (also known as 'August lily' or 'Plantain lily') is originated from China and usually grown for ornamental purposes (Fig. Read More

    Variation in aluminium patch test reactivity over time.
    Contact Dermatitis 2017 Jul 11. Epub 2017 Jul 11.
    Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 20502, Malmö, Sweden.
    Background: Contact allergy to aluminium has been reported more frequently in recent years. It has been pointed out that positive patch test reactions to aluminium may not be reproducible on retesting.

    Objectives: To investigate possible variations in patch test reactivity to aluminium over time. Read More

    [Basis for the treatment of eczematous diseases in otorhinolaryngology].
    HNO 2017 Jul 10. Epub 2017 Jul 10.
    Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland.
    According to Coombs and Gell, cell-mediated immune responses belong to type IV reactions and are borne mainly by T lymphocytes. The eliciting allergens are usually so-called haptens. Haptens are substances which develop to whole antigens only by binding to protein carriers. Read More

    In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis.
    J Control Release 2017 Jul 8;261:223-233. Epub 2017 Jul 8.
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, United States; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, United States; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA 15261, United States; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, United States. Electronic address:
    Allergic contact dermatitis (ACD) is a common T-cell mediated inflammatory skin condition, characterized by an intensely pruritic rash at the site of contact with allergens like poison ivy or nickel. Current clinical treatments use topical corticosteroids, which broadly and transiently suppress inflammation and symptoms of ACD, but fail to address the underlying immune dysfunction. Here, we present an alternative therapeutic approach that teaches the immune system to tolerate contact allergens by expanding populations of naturally suppressive allergen-specific regulatory T cells (Tregs). Read More

    Of self-lipids, CD1-restricted T cells, and contact sensitization.
    Eur J Immunol 2017 Jul;47(7):1119-1122
    Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
    Contact hypersensitivity (CHS) in rodents and contact dermatitis in humans are long-known pathological conditions caused by MHC-restricted T-cell responses. These responses are triggered upon T-cell recognition of neo-antigenic determinants, which are generated by a variety of environmental contact sensitizer (CS) chemicals associating with self-proteins to comprise these neo-antigens. In this issue of the European Journal of Immunology, Betts et al. Read More

    Simultaneous patch testing with fragrance mix I, fragrance mix II and their ingredients in southern Sweden between 2009 and 2015.
    Contact Dermatitis 2017 Jul 7. Epub 2017 Jul 7.
    Lund University, Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, 205 02, Malmö, Sweden.
    Background: Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy.

    Objectives: To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients.

    Materials And Methods: A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. Read More

    Allergic contact dermatitis to acrylates.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2):529-534
    Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, Bari, Italy.
    Acrylates and methacrylates are a large group of chemically reactive monomers that are polymerized into acrylic plastics. These have very broad applications in glues, coatings and various plastic materials. Allergic contact dermatitis (ACD) caused by acrylates can be occupational, mainly in dentistry workers during the manufacturing and implantation of dental prosthesis, and in nail technicians during the sculpturing and application of artificial nails. Read More

    Intestinal Stomas-Postoperative Stoma Care and Peristomal Skin Complications.
    Clin Colon Rectal Surg 2017 Jul 22;30(3):184-192. Epub 2017 May 22.
    Section of Colon and Rectal Surgery, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois.
    Intestinal stomas are necessary for several colon and rectal conditions and represent a major change in the new ostomate's daily life. Though dehydration is the most frequent etiology requiring readmission, irritant contact dermatitis and a host of other peristomal skin conditions are more common complications for ostomates. Wound, ostomy, and continence nurses are invaluable resources to both ostomy patients and providers. Read More

    Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens.
    Contact Dermatitis 2017 Jul 5. Epub 2017 Jul 5.
    Department of Dermatology-Allergy, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900, Hellerup, Denmark.
    Allergic contact dermatitis is one of the most frequent forms of skin inflammation. Very often, we are exposed to mixtures of allergens with varying potencies, doses/areas, and exposure times. Therefore, improved knowledge about immune responses to combinations of contact allergens is highly relevant. Read More

    Allergic contact dermatitis caused by a new temporary blue-black tattoo dye - sensitization to genipin from jagua (Genipa americana L.) fruit extract.
    Contact Dermatitis 2017 Jul 4. Epub 2017 Jul 4.
    Kantonales Laboratorium Basel-Stadt, 4056 Basel, Switzerland.
    Background: Temporary tattoos made with an extract of the jagua fruit (Genipa americana L.) are becoming increasingly popular. It is claimed that it is 'dermatologically tested' and does not contain p-phenylenediamine. Read More

    A population-based study of self-reported skin exposures and symptoms in relation to contact allergy in adolescents.
    Contact Dermatitis 2017 Jul 4. Epub 2017 Jul 4.
    Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.
    Background: Knowledge about the relations between skin exposures, skin symptoms and contact allergy in adolescents is limited.

    Objectives: To explore self-reported skin exposures and skin symptoms in girls and boys, and to assess the associations between exposures, symptoms and contact allergy at age 16 years.

    Participants And Methods: In all, 3115 adolescents from the population-based BAMSE birth cohort answered a questionnaire at age 16 concerning various skin exposures and related skin symptoms. Read More

    Biological monitoring of dermal and air exposure to cobalt at a Swedish hard metal production plant: does dermal exposure contribute to uptake?
    Contact Dermatitis 2017 Jul 4. Epub 2017 Jul 4.
    Department of Occupational and Environmental Medicine, Örebro University, 701 85, Örebro, Sweden.
    Background: Occupational exposure to cobalt is well established in hard metal manufacture. Cobalt is known to cause contact allergy, asthma, hard metal lung disease, and lung cancer. The relationship between skin exposure and uptake determined in blood has not been extensively investigated. Read More

    Preservatives in Personal Hygiene and Cosmetic Products, Topical Medications, and Household Cleaners in Spain.
    Actas Dermosifiliogr 2017 Jun 30. Epub 2017 Jun 30.
    Servicio de Dermatología, Hospital Universitario de Guadalajara , Guadalajara, España; Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, España.
    Introduction: Preservatives are added to cosmetic, household cleaning, and other industrial products to prevent the growth of microorganisms. Unfortunately, exposure to these substances can cause sensitization.

    Material And Methods: Between January and June 2015, we analyzed the ingredients of 2300 products commercially available in Spain to identify the frequency of a wide variety of preservatives in different product categories. Read More

    Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy.
    Int J Mol Sci 2017 Jun 25;18(7). Epub 2017 Jun 25.
    Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.
    Palladium is frequently used in dental materials, and sometimes causes metal allergy. It has been suggested that the immune response by palladium-specific T cells may be responsible for the pathogenesis of delayed-type hypersensitivity in study of palladium allergic model mice. In the clinical setting, glucocorticoids and antihistamine drugs are commonly used for treatment of contact dermatitis. Read More

    Contact allergy in the population of patients with chronic inflammatory dermatoses and contact hypersensitivity to corticosteroids.
    Postepy Dermatol Alergol 2017 Jun 29;34(3):253-259. Epub 2017 May 29.
    Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
    Introduction: Clinical studies indicate that contact allergy to glucocorticosteroids (GCS) is not rare and has been increasingly reported over the past decade. Among the risk factors for developing contact hypersensitivity to topical corticosteroids, chronic inflammatory skin diseases and polyvalent contact allergy seem to be most important.

    Aim: To present the structure of contact allergy in the population of patients with chronic inflammatory dermatoses (CID) and contact hypersensitivity to corticosteroids. Read More

    Allergic contact dermatitis pattern in Kuwait: nickel leads the pack. In-depth analysis of nickel allergy based on the results from a large prospective patch test series report.
    Postepy Dermatol Alergol 2017 Jun 29;34(3):207-215. Epub 2017 May 29.
    Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.
    Introduction: Contact dermatitis is a relatively common dermatosis reported among several population groups from all around the globe. However, the data from Kuwait is unavailable. Patch tests are essential for the diagnosis of contact sensitization. Read More

    Skin Health Connected to the Use of Absorbent Hygiene Products: A Review.
    Dermatol Ther (Heidelb) 2017 Jun 30. Epub 2017 Jun 30.
    SCA Hygiene Products AB, Göteborg, Sweden.
    Over the past 50 years, absorbent hygiene products such as baby diapers and incontinence products have become essential features of modern day life. Through innovation and enhanced technology, their design, composition and performance have been dramatically upgraded from their early forms, and they have transformed the lives of millions of people, improving their quality of life. Skin health related to the use of absorbent hygiene products has accordingly also greatly improved. Read More

    Minimum standards on prevention, diagnosis and treatment of occupational and work-related skin diseases in Europe - position paper of the COST Action StanDerm (TD 1206).
    J Eur Acad Dermatol Venereol 2017 Jun;31 Suppl 4:31-43
    Department of Dermatology, Hospital del Mar, Institut Mar d´Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona, Barcelona, Spain.
    Background: Skin diseases constitute up to 40% of all notified occupational diseases in most European countries, predominantly comprising contact dermatitis, contact urticaria, and skin cancer. While insufficient prevention of work-related skin diseases (WRSD) is a top-priority problem in Europe, common standards for prevention of these conditions are lacking.

    Objective: To develop common European standards on prevention and management of WRSD and occupational skin diseases (OSD). Read More

    Meta-analysis of randomized and quasi-randomized clinical trials of topical antibiotics after primary closure for the prevention of surgical-site infection.
    Br J Surg 2017 Aug 28;104(9):1123-1130. Epub 2017 Jun 28.
    Discipline of General Practice, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
    Background: Surgical-site infections (SSIs) increase patient morbidity and costs. The aim was to identify and synthesize all RCTs evaluating the effect of topical antibiotics on SSI in wounds healing by primary intention.

    Methods: The search included Ovid MEDLINE, Ovid Embase, the Cochrane Wounds Specialized Register, Central Register of Controlled Trials and EBSCO CINAHL from inception to May 2016. Read More

    Allergic contact dermatitis caused by (meth)acrylates in long-lasting nail polish - are we facing a new epidemic in the beauty industry?
    Contact Dermatitis 2017 Jun 27. Epub 2017 Jun 27.
    Dermatology Department, Alicante General Hospital, 03010, Alicante, Spain.
    Background: Allergic contact dermatitis (ACD) caused by (meth)acrylates has been described both in occupational and in non-occupational settings.

    Objectives: To evaluate the clinical patterns, the most frequent allergens and the prognosis in patients sensitized to (meth)acrylates in long-lasting nail polish.

    Methods: The files of patients with ACD caused by (meth)acrylates in long-lasting nail polish diagnosed between January 2013 and June 2016 in four dermatology departments in Spain were reviewed. Read More

    Allergy and Sexual Behaviours: an Update.
    Clin Rev Allergy Immunol 2017 Jun 26. Epub 2017 Jun 26.
    Department of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Florence, Italy.
    The exact prevalence of hypersensitivity reactions related to sexual behaviours is not known; however, they heavily impact on the quality of life and of sex life of affected patients. In fact, not only common respiratory and skin allergies, such as asthma, rhinitis, urticaria and atopic dermatitis, but also food and drug allergy have been found to negatively affect the quality of sex life. Allergic diseases impact on the sexual function in both physical and psychological ways, representing one of the main complaints of a considerable proportion of patients. Read More

    The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm.
    Adv Ther 2017 Jul 23;34(7):1594-1609. Epub 2017 Jun 23.
    Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Alopecia areata (AA), a prevalent inflammatory cause of hair loss, lacks FDA-approved therapeutics for extensive cases, which are associated with very poor rates of spontaneous hair regrowth and major psychological distress. Current treatments for severe cases include broad immune-suppressants, which are associated with significant adverse effects, precluding long-term use, with rapid hair loss following treatment termination. As a result of the extent of the disease in severe cases, topical contact sensitizers and intralesional treatments are of limited use. Read More

    Immunomodulatory Effects of Nanoparticles on Skin Allergy.
    Sci Rep 2017 Jun 21;7(1):3979. Epub 2017 Jun 21.
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA.
    In recent years there has been considerable effort to understand the interaction of nanomaterials with the skin. In this study we use an in vivo mouse model of allergic contact dermatitis to investigate how nanoparticles (NPs) may alter allergic responses in skin. We investigate a variety of NPs that vary in size, charge and composition. Read More

    Nickel sulfate promotes IL-17A producing CD4+ T-cells by an IL-23 dependent mechanism regulated by TLR4 and Jak-STAT pathways.
    J Invest Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Inflammation Chimiokines et Immunopathologie, INSERM, Fac. de pharmacie - Univ.Paris-Sud, Université Paris-Saclay, Châtenay-Malabry, France. Electronic address:
    Allergic contact dermatitis, caused by nickel, is a delayed-type hypersensitivity reaction and 14.5% of the general population may be affected in Europe. Among a wide range of cytokines, the IL-12 family has unique structural and immunological characteristics. Read More

    Allergic contact dermatitis from ophthalmics.
    Cutan Ocul Toxicol 2017 Mar 6:1-4. Epub 2017 Mar 6.
    c Department of Dermatology , University of California at San Francisco Medical School , San Francisco , CA , USA.
    In this article we summarize the recently described allergens responsible for allergic contact dermatitis due to ophthalmic drugs and contact lens solutions, and emphaage the need on how to perform diagnostic testing in this special clinical entity. Read More

    European Surveillance System on Contact Allergies (ESSCA): results with the European baseline series, 2013/14.
    J Eur Acad Dermatol Venereol 2017 Jun 19. Epub 2017 Jun 19.
    Dermatology, Leeds Teaching Hospitals NHS Trust, Leeds, LS7 4SA, U.K.
    Background: Contact allergy is a common condition and can severely interfere with daily life or professional activities. Due to changes in exposures, a consequence of introduction of new substances, new products or formulations, and regulatory intervention, the spectrum of contact sensitisation changes.

    Objective: To evaluate the current spectrum of contact allergy to allergens present in the European baseline series (EBS) across Europe. Read More

    1 OF 734