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    Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.
    Mucosal Immunol 2017 Feb 22. Epub 2017 Feb 22.
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD). However, the mechanism by which the expression of these innate cytokines is regulated remains unclear. Intelectin (ITLN) is expressed in airway epithelial cells and promotes allergic airway inflammation. Read More

    Topical Application of Eupatilin Ameliorates Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.
    Ann Dermatol 2017 Feb 3;29(1):61-68. Epub 2017 Feb 3.
    Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Background: Atopic dermatitis (AD) is an inflammatory skin disorder with severe pruritus. Despite advancements in medicine, therapeutic treatments for AD are still limited. Eupatilin (5,7-dihydroxy-30,40,6-trimethoxyflavone) is one of the lipophilic flavonoids from Artemisia umbelliformis Lam. Read More

    Effectiveness of Specific Sublingual Immunotherapy in Korean Patients with Atopic Dermatitis.
    Ann Dermatol 2017 Feb 3;29(1):1-5. Epub 2017 Feb 3.
    Department of Dermatology, Pusan National University School of Medicine, Busan, Korea.; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
    Background: Sublingual immunotherapy (SLIT) with house dust mites (HDM) preparation has recently been proven to be beneficial for treating allergic rhinitis and asthma. However, there has been no report regarding the efficacy and safety of SLIT in Korean patients with atopic dermatitis (AD).

    Objective: We intended to investigate the efficacy and safety of SLIT in Korean patients with AD. Read More

    Needs" in Patients of Neurodermatitis Circumscripta (Lichen Simplex Chronicus).
    Indian J Dermatol Venereol Leprol 1980 Mar-Apr;46(2):104-107
    Psychological needs of 20 adult male patients with neurodermatitis circumscripta(lichen simplex chronicus) and 50 matched controls were studied using ten TAT cards.Need affiliation(100%) need achievement (95%),need superiority (55%) and need dominance(40%) were the predominant needs.In contrast to the findings in other studies where aggressive needs were high in patients with atopic dermatitis our study showed that it was a prominent need in only one patient with neurodermatitis circumscripta. Read More

    Effect of Bronchial Asthama on Porphyrin Levels in Patients of Atopic Dermatitis - a Spectrophotometric Study.
    Indian J Dermatol Venereol Leprol 1980 Sep-Oct;46(5):263-266
    A quantitative assay of porphyrins in blood, urine and stool of 30 patients with atopic dermatitis, 17 without and 13 with bronchial asthma was done. Rimington's technique for the estimation of porphyrins was employed. No statistically significant difference in porphyrin levels was observed between patients without and with bronchial asthma. Read More

    The effects of a topical lipid complex therapy on dogs with atopic dermatitis: a double blind, randomized, placebo-controlled study.
    Vet Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinaerstraße 13, 80539, Munich, Germany.
    Background: Canine atopic dermatitis is a common clinical presentation. The skin barrier seems to play a fundamental role in the pathogenesis. Therefore a topical spot-on product containing a mixture of lipids may improve clinical signs without adverse effects if it were to improve stratum corneum barrier function. Read More

    Cordycepin diminishes thymic stromal lymphopoietin-induced interleukin-13 production.
    Eur J Pharmacol 2017 Feb 17. Epub 2017 Feb 17.
    Department of Food Science & Technology, Hoseo University, 20, Hoseo-ro 79beon-gil, Baebang-eup, Asan, Chungcheongnam-do 31499, Republic of Korea. Electronic address:
    Atopic dermatitis (AD) is known to aggravate by thymic stromal lymphopoietin (TSLP) and TSLP is also known to up-regulate mast cell proliferation via production of interleukin (IL)-13. Thus, we investigated whether cordycepin could regulate mast cell proliferation induced by TSLP in human mast cell line, HMC-1 cell. Cordycepin significantly diminished the production and mRNA of IL-13 through the down-regulation of phosphorylated-signal transducer and activation of transcription 6 in the TSLP-stimulated HMC-1 cells. Read More

    A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus.
    Genome Med 2017 Feb 20;9(1):18. Epub 2017 Feb 20.
    Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), 8A Biomedical Grove #04-06, Singapore, 138648, Republic of Singapore.
    Background: Expression quantitative trait loci (eQTL) databases represent a valuable resource to link disease-associated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation. We previously identified signal inhibitory receptor on leukocytes-1 (SIRL-1) as a powerful regulator of human innate immune cell function. While it is constitutively high expressed on neutrophils, on monocytes the SIRL-1 surface expression varies strongly between individuals. Read More

    [Function and modulation of type Ⅱ innate lymphoid cells and their role in chronic upper airway inflammatory diseases].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Feb;52(2):130-135
    Department of Otorhinolaryngology of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
    Type Ⅱ innate lymphoid cells (ILC2) is a family of innate immune lymphocytes, which provide effective immune responses to cytokines. ILC2 are regulated by the nuclear transcription factor ROR alpha and GATA3, secreting cytokines IL-5 and IL-13, etc. Animal models have shown that ILC2 are involved in allergic diseases, such as asthma and atopic dermatitis, and also play a very important role in the metabolic balance. Read More

    Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.
    Int Arch Allergy Immunol 2017 Feb 21;172(1):11-19. Epub 2017 Feb 21.
    Departments of Dermatology, Venereology, and Allergology, Medical University of Gdansk, Gdansk, Poland.
    Background: It is assumed that beside alterations in the filaggrin gene (FLG), disturbances within genes encoding other cornified envelope proteins are also involved in atopic dermatitis (AD). To identify new potential markers of AD, we studied the polymorphisms of genes encoding repetin (RPTN), cornulin (CRNN), and their expression in the skin of AD patients.

    Methods: Polymorphisms in CRNN (rs941934), RPTN (rs284544, rs28441202, rs3001978, and rs12117644), and FLG mutations (R2447X, S3247X) were analyzed by TaqMan genotyping assay and by PCR-RFLP in the blood samples of 159 AD patients and 108 healthy subjects. Read More

    Maternal stress and psychological distress preconception: association with offspring atopic eczema at age 12 months.
    Clin Exp Allergy 2017 Feb 20. Epub 2017 Feb 20.
    Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, UK.
    Background: Perinatal maternal stress and low mood have been linked to offspring atopic eczema.

    Objectives: To examine the relation of maternal stress/mood with atopic eczema in the offspring, focusing particularly on stress/psychological distress preconception.

    Methods: At recruitment in the UK Southampton Women's Survey, preconception maternal reports of perceived stress in daily living and the effect of stress on health were recorded; in a sub-sample psychological distress was assessed (12-item General Health Questionnaire). Read More

    Bee Venom Phospholipase A2 Ameliorates House Dust Mite Extract Induced Atopic Dermatitis Like Skin Lesions in Mice.
    Toxins (Basel) 2017 Feb 18;9(2). Epub 2017 Feb 18.
    Department of Science in Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 02447, Korea.
    Atopic dermatitis (AD) is a biphasic inflammatory skin disease that is provoked by epidermal barrier defects, immune dysregulation, and increased skin infections. Previously, we have demonstrated that bvPLA2 evoked immune tolerance by inducing regulatory T cells (Treg), and thus alleviated Th2 dominant allergic asthma in mice. Here, we would like to determine whether treatment with bvPLA2 exacerbates the AD-like allergic inflammations induced by house dust mite extract (DFE) in a murine model. Read More

    Risk of Non-melanoma Skin Cancer in Patients with Atopic Dermatitis Treated with Oral Immunosuppressive Drugs.
    Acta Derm Venereol 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
    There is uncertainty about the risk of developing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma (SCC), in patients with atopic dermatitis (AD) treated with oral immunosuppressive drugs. A total of 557 patients with AD treated with these drugs in the University Medical Center Utrecht and Groningen, the Netherlands, were analysed. NMSC after oral immunosuppressive treatment was reported in 18 patients (3. Read More

    Disseminate and recurrent infundibulo-folliculitis in an Indian patient: A case report with review of literature.
    Indian Dermatol Online J 2017 Jan-Feb;8(1):39-41
    Department of Pathology, Government Medical College, Trivandrum, Kerala, India.
    A 17-year-old male patient presented with multiple discrete and confluent monomorphic skin-colored pinhead-sized follicular papules, with occasional pustules distributed on the neck, upper chest, upper posterior trunk, and proximal extremities of 4 months duration. The lesions were asymptomatic, and there was no prior history of topical application or history of atopic dermatitis. Routine investigations were normal. Read More

    Clinical Signs, Staphylococcus and Atopic Eczema-Related Seromarkers.
    Molecules 2017 Feb 14;22(2). Epub 2017 Feb 14.
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China.
    Childhood eczema or atopic dermatitis (AD) is a distressing disease associated with pruritus, sleep disturbance, impaired quality of life and Staphylococcus aureus isolation. The pathophysiology of AD is complex and various seromarkers of immunity are involved. We investigated if anti-staphylococcal enterotoxin IgE (anti-SE), selected seromarkers of T regulatory (Treg), T helper (Th) and antigen-presenting cells (APC) are associated with clinical signs of disease severity and quality of life. Read More

    The Role of Neurotrophins in Inflammation and Allergy.
    Vitam Horm 2017 29;104:313-341. Epub 2016 Nov 29.
    Center for Pediatric Research, Cleveland Clinic Foundation, Cleveland, OH, United States; Pediatric Institute and Children's Hospital, Cleveland Clinic Foundation, Cleveland, OH, United States. Electronic address:
    Allergic inflammation is the result of a specific pattern of cellular and humoral responses leading to the activation of the innate and adaptive immune system, which, in turn, results in physiological and structural changes affecting target tissues such as the airways and the skin. Eosinophil activation and the production of soluble mediators such as IgE antibodies are pivotal features in the pathophysiology of allergic diseases. In the past few years, however, convincing evidence has shown that neurons and other neurosensory structures are not only a target of the inflammatory process but also participate in the regulation of immune responses by actively releasing soluble mediators. Read More

    The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice.
    Pharmacology 2017 Feb 18;99(5-6):259-267. Epub 2017 Feb 18.
    Drug Discovery and Disease Research Laboratory,SHIONOGI & Co., Ltd., Osaka, Japan.
    We investigated the effects of S-777469 (1-[[6-Ethyl-1-[4-fluorobenzyl]-5-methyl-2-oxo-1, 2-dihydropyridine-3-carbonyl]amino]-cyclohexanecarboxylic acid), a novel cannabinoid type 2 receptor (CB2) agonist, on 1-fluoro-2,4-dinitrobenzene (DNFB)-induced ear inflammation and mite antigen-induced dermatitis in mice. The oral administration of S-777469 significantly suppressed DNFB-induced ear swelling in a dose-dependent manner. In addition, S-777469 significantly alleviated mite antigen-induced atopic dermatitis-like skin lesions in NC/Nga mice. Read More

    Japanese guidelines for allergic rhinitis 2017.
    Allergol Int 2017 Feb 14. Epub 2017 Feb 14.
    Department of Otorhinolaryngology, Head & Neck Surgery, University of Yamanashi, Yamanashi, Japan.
    Like asthma and atopic dermatitis, allergic rhinitis is an allergic disease, but of the three, it is the only type I allergic disease. Allergic rhinitis includes pollinosis, which is intractable and reduces quality of life (QOL) when it becomes severe. A guideline is needed to understand allergic rhinitis and to use this knowledge to develop a treatment plan. Read More

    Filaggrin loss-of-function mutations, atopic dermatitis and risk of actinic keratosis: results from two cross-sectional studies.
    J Eur Acad Dermatol Venereol 2017 Feb 18. Epub 2017 Feb 18.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    Background: Common loss-of-function mutations in filaggrin gene (FLG) represent a strong genetic risk factor for atopic dermatitis (AD). Homozygous mutation carriers typically display ichthyosis vulgaris (IV) and many have concomitant AD. Previously, homozygous, but not heterozygous, filaggrin gene mutations have been associated with squamous cell carcinomas. Read More

    The Skin as a Route of Allergen Exposure: Part II. Allergens and Role of the Microbiome and Environmental Exposures.
    Curr Allergy Asthma Rep 2017 Jan;17(1)
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
    Purpose Of Review: This second part of the article aims to highlight recent contributions in the literature that enhance our understanding of the cutaneous immune response to allergen.

    Recent Findings: Several properties of allergens facilitate barrier disruption and cutaneous sensitization. There is a strong epidemiologic relationship between the microbiome, both the gut and skin, and atopic dermatitis (AD). Read More

    Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities.
    Pain Rep 2016 Sep;1(3)
    Department of Anesthesiology, Washington University School of Medicine, Washington University Pain Center, St Louis, MO, USA; Department of Neuroscience, Washington University School of Medicine, MO, USA.
    Introduction: Epidermal keratinocytes are increasingly recognized as active participants in the sensory transduction of itch and pain, processes known to involve primary afferent glutamatergic neurons. However the role of keratinocyte glutamate signaling in sensory functioning is not fully understood. Here, we present the observation of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid type glutamate receptors (AMPAR) in epidermal keratinocytes. Read More

    Usefulness of Sweat Management for Patients with Adult Atopic Dermatitis, regardless of Sweat Allergy: A Pilot Study.
    Biomed Res Int 2017 22;2017:8746745. Epub 2017 Jan 22.
    Department of Dermatology, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
    Background. Sweat is an aggravating factor in atopic dermatitis (AD), regardless of age. Sweat allergy may be involved in AD aggravated by sweating. Read More

    Hyperforin/HP-β-Cyclodextrin Enhances Mechanosensitive Ca(2+) Signaling in HaCaT Keratinocytes and in Atopic Skin Ex Vivo Which Accelerates Wound Healing.
    Biomed Res Int 2017 22;2017:8701801. Epub 2017 Jan 22.
    Mechanobiology Laboratory, Nagoya University Graduate School of Medicine, 65 Tsurumai, Nagoya 466-8550, Japan.
    Cutaneous wound healing is accelerated by mechanical stretching, and treatment with hyperforin, a major component of a traditional herbal medicine and a known TRPC6 activator, further enhances the acceleration. We recently revealed that this was due to the enhancement of ATP-Ca(2+) signaling in keratinocytes by hyperforin treatment. However, the low aqueous solubility and easy photodegradation impede the topical application of hyperforin for therapeutic purposes. Read More

    Non-topical management of recalcitrant paediatric atopic dermatitis.
    Arch Dis Child 2017 Feb 16. Epub 2017 Feb 16.
    Dermatology service, KK Women's and Children's Hospital, Singapore.
    Atopic dermatitis (AD) is a common chronic, pruritic skin disease in children. As the incidence of AD increases, especially in high-income countries, paediatricians may see an increasing number of recalcitrant AD cases in their practice. Although these cases are principally managed by paediatric dermatologists, it is important for paediatricians to be aware of the use and side effects of non-topical treatment like phototherapy and systemic agents as well as the evidence for alternative treatment, which caregivers may ask about. Read More

    A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis.
    J Allergy Clin Immunol 2017 Jan 31. Epub 2017 Jan 31.
    University of Colorado Denver, Aurora, Colo.
    Background: Antibody responses to the inactivated seasonal influenza vaccine in patients with atopic dermatitis (AD) have not been carefully characterized.

    Objective: The primary objective of this study was to compare antibody responses to intradermal vaccination in participants with moderate/severe AD with those in nonatopic participants. Secondary objectives were to evaluate the effect of route of administration, Staphylococcus aureus skin colonization, and disease severity on vaccine response. Read More

    Japanese guidelines for atopic dermatitis 2017.
    Allergol Int 2017 Feb 10. Epub 2017 Feb 10.
    Department of Dermatology, Nara Hospital, Kinki University Faculty of Medicine, Nara, Japan.
    Given the importance of appropriate diagnosis and appropriate assessment of cutaneous symptoms in treatment of atopic dermatitis, the basics of treatment in this guideline are composed of (1) investigation and countermeasures of causes and exacerbating factors, (2) correction of skin dysfunctions (skin care), and (3) pharmacotherapy, as three mainstays. These are based on the disease concept that atopic dermatitis is an inflammatory cutaneous disease with eczema by atopic diathesis, multi-factorial in onset and aggravation, and accompanied by skin dysfunctions. These three points are equally important and should be appropriately combined in accordance with the symptoms of each patient. Read More

    Knowledge, attitudes and practices of the medical personnel regarding atopic dermatitis in Yaoundé, Cameroon.
    BMC Dermatol 2017 Feb 16;17(1). Epub 2017 Feb 16.
    Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box: 8314, Yaoundé, Cameroon.
    Background: Atopic dermatitis (AD) is a chronic, relapsing and pruritic inflammatory skin disease whose management remains unclear to most non-dermatologists. This study aimed to assess the knowledge, attitudes and practices (KAP) of the medical staff regarding AD in Yaoundé, Cameroon.

    Methods: This was a cross-sectional study conducted from January to April 2014 in 20 health facilities located in Yaoundé, the capital city of Cameroon. Read More

    Glucosylsphingosine Activates Serotonin Receptor 2a and 2b: Implication of a Novel Itch Signaling Pathway.
    Biomol Ther (Seoul) 2017 Feb 17. Epub 2017 Feb 17.
    College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
    Recent reports claimed that glucosylsphingosine (GS) is highly accumulated and specifically evoking itch-scratch responses in the skins of atopic dermatitis (AD) patients. However, it was unclear how GS can trigger itch-scratch responses, since there were no known molecular singling pathways revealed yet. In the present study, it was verified for the first time that GS can activate mouse serotonin receptor 2a (mHtr2a) and 2b (mHtr2b), but not 2c (mHtr2c) that are expressed in HEK293T cells. Read More

    The Role of the Skin Microbiome in Atopic Dermatitis: A Systematic Review.
    Br J Dermatol 2017 Feb 16. Epub 2017 Feb 16.
    National Allergy Research Centre, Herlev & Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Background: Dysbiosis is a hallmark of atopic dermatitis. The composition of skin microbiome communities and the causality of dysbiosis in eczema have not been well established.

    Objective: To describe the skin microbiome profile in atopic dermatitis and address if there is a causal relationship between dysbiosis and atopic dermatitis. Read More

    Allergic rhinitis, atopic dermatitis, and asthma are associated with differences in school performance among Korean adolescents.
    PLoS One 2017 16;12(2):e0171394. Epub 2017 Feb 16.
    Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Korea.
    Several studies have reported negative relations between allergic diseases and school performance but have not simultaneously considered various allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, and only examined a limited number of participants. The present study investigated the associations of allergic rhinitis, asthma, and atopic dermatitis with school performance in a large, representative Korean adolescent population. A total of 299,695 7th through 12th grade students participated in the Korea Youth Risk Behaviour Web-based Survey (KYRBWS) from 2009 to 2013. Read More

    Osteoporosis in adult patients with atopic dermatitis: A nationwide population-based study.
    PLoS One 2017 16;12(2):e0171667. Epub 2017 Feb 16.
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    The aim of this study was to investigate osteoporosis risk in atopic dermatitis (AD) patients. This study included patients in the Taiwan National Health Insurance Research dataset. The population-based study included all patients aged 20-49 years who had been diagnosed with AD during 1996-2010. Read More

    Quality of Life of Parents of Children with Atopic Dermatitis.
    Acta Derm Venereol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
    Atopic dermatitis (AD) is the most common chronic dermatitis in children. The influence of AD on quality of life of parents of children with AD was studied using the Family Dermatology Life Quality Index (FDLQI). Fifty children with AD were included in the study (age range 2-24 months) together with their parents. Read More

    Low maternal prenatal 25-hydroxy vitamin D blood levels are associated with childhood atopic dermatitis.
    J Invest Dermatol 2017 Feb 12. Epub 2017 Feb 12.
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Park Drive, Suite 401, Boston MA 02215.

    Critically appraised topic on adverse food reactions of companion animals (3): prevalence of cutaneous adverse food reactions in dogs and cats.
    BMC Vet Res 2017 Feb 15;13(1):51. Epub 2017 Feb 15.
    Medizinische Kleintierklinik, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinärstrasse 13, 80539, Munich, Germany.
    Background: The prevalence of cutaneous adverse food reactions (CAFRs) in dogs and cats is not precisely known. This imprecision is likely due to the various populations that had been studied. Our objectives were to systematically review the literature to determine the prevalence of CAFRs among dogs and cats with pruritus and skin diseases. Read More

    Therapeutic Effects of Fermented Flax Seed Oil on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions.
    Evid Based Complement Alternat Med 2017 19;2017:5469125. Epub 2017 Jan 19.
    Department of Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Dongguk University, Dongguk-ro 27, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Republic of Korea.
    Background. Atopic Dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Objective. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Effects of air pollution on the skin: A review.
    Indian J Dermatol Venereol Leprol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Skin and STD, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Read More

    IL-1beta induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermis.
    J Pathol 2017 Feb 13. Epub 2017 Feb 13.
    In vitro Pharmacology, Department R&D, Pierre Fabre Dermo-Cosmétique, Toulouse, France.
    Atopic dermatitis (AD) is a common skin inflammatory disease characterized by the production of thymic stromal lymphopoietin (TSLP) and a marked TH 2 polarization. Recent studies suggest that IL-1β contributes to the development of AD skin inflammation. Here, we have investigated the impact of IL-1β signalling on the epidermal homeostasis of both healthy subjects and AD patient [with functional filaggrin (FLG) alleles] with particular attention to TSLP production and keratinocyte differentiation. Read More

    Immediate-type allergic and protease-mediated reactions are involved in scratching behavior induced by topical application of Dermatophagoides farinae extract in NC/Nga mice.
    Exp Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Strategic Research Planning & Management department, Kyoto R&D Center, Maruho Co., Ltd., Kyoto, Japan.
    Atopic dermatitis (AD)-like dermatitis can be induced by repeated topical application of an ointment containing Dermatophagoides farinae body (Dfb) extract in NC/Nga mice. This AD-like murine model also exhibits a biphasic increase in the number of scratching behavior after topical application of Dfb ointment. In this study, we investigated the possible mechanisms underlying the scratching behavior in each phase. Read More

    Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases.
    Exp Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function. Read More

    The histopathological differentiation between palmar psoriasis and hand eczema: A retrospective review of 96 cases.
    J Am Acad Dermatol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
    Background: The histopathologic differences among palmar psoriasis (PP), hand eczema (HE), and hyperkeratotic hand dermatitis (HHD) have been poorly described.

    Objectives: We sought to distinguish among PP, HE, and HHD on a histopathologic basis.

    Methods: We retrospectively analyzed the histology of hematoxylin-eosin-stained sections obtained from 96 patients diagnosed with PP, HE, or HHD. Read More

    [Safety of subcutaneous immunotherapy with tyrosine-adsorbed house dust mite extracts in patients with allergic disease].
    Rev Alerg Mex 2017 Jan-Mar;64(1):52-65
    Universidad de Antioquia, IPS Universitaria, Servicio Alergología Clínica. Grupo de Alergología Clínica y Experimental. Medellín, Colombia.
    Background: In spite of allergen-specific immunotherapy (SIT) multiple benefits, its use is restricted in some countries owing to concerns about severe adverse reactions.

    Objective: To evaluate systemic adverse reactions in patients with atopic dermatitis, allergic asthma, allergic rhinitis and allergic conjunctivitis who received subcutaneous immunotherapy with tyrosine-adsorbed Dermatophagoides and Glycyphagoides dust mites extracts.

    Methods: Retrospective study of the 2010-2015-period that included 773 patients diagnosed with IgE-mediated diseases, where the safety of allergen-specific immunotherapy was described according to the World Organization of Allergy subcutaneous immunotherapy-induced systemic reactions classification system. Read More

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