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    Eczema, Atopic Dermatitis, or Atopic Eczema: Analysis of Global Search Engine Trends.
    Dermatitis 2017 Jul/Aug;28(4):276-279
    From the *Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL; †Department of Dermatology, Gentofte University Hospital, Hellerup, Denmark; and Departments of ‡Pediatrics, §Preventive Medicine, and ∥Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.
    Background: The lack of standardized nomenclature for atopic dermatitis (AD) creates challenges for scientific communication, patient education, and advocacy.

    Objective: We sought to determine the relative popularity of the terms eczema, AD, and atopic eczema (AE) using global search engine volumes.

    Methods: A retrospective analysis of average monthly search volumes from 2014 to 2016 of Google, Bing/Yahoo, and Baidu was performed for eczema, AD, and AE in English and 37 other languages. Read More

    [Diseases affecting the scalp].
    Cas Lek Cesk 2017 ;156(3):137-140
    The skin of the scalp differs from the skin on the other areas of the body because of a higher density of hair follicles and higher sebum production. These, together with the presence of hair, provide a suitable environment for superficial infections, infestations and inflammatory diseases. The good condition of the scalp has a significant impact on the patient's mental well-being and social interaction. Read More

    Wet work exposure and hand eczema among healthcare workers - a cross-sectional study.
    Br J Dermatol 2017 Jul 19. Epub 2017 Jul 19.
    Lund University, Skåne University Hospital, Department of Occupational and Environmental Dermatology, Malmö, Sweden.
    Background: Hand eczema is more common in healthcare workers compared to the general population. The hands are subject to changing occupational exposures due to mandatory hygiene regulations for health care workers.

    Objectives: To describe the exposure due to hygiene procedures and investigate the associations between occupational hand washing, use of non-sterile gloves, and hand disinfectant and self-reported hand eczema. Read More

    Effect of a lotion containing the heat-treated probiotic strain Lactobacillus johnsonii NCC 533 on Staphylococcus aureus colonization in atopic dermatitis.
    Clin Cosmet Investig Dermatol 2017 3;10:249-257. Epub 2017 Jul 3.
    Medical Affairs Department, Galderma International, Paris, France.
    Objective: Staphylococcus aureus dominates the skin microbiota in patients with atopic dermatitis (AD), with bacterial loads correlating with disease severity. The aim of this exploratory study was to investigate the effect of a cosmetic lotion containing heat-treated Lactobacillus johnsonii NCC 533 (HT La1) on S. aureus colonization in AD patients. Read More

    Prenatal and postnatal administration of prebiotics and probiotics.
    Semin Fetal Neonatal Med 2017 Jul 15. Epub 2017 Jul 15.
    Department of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, USA. Electronic address:
    Colonization of the neonatal gut by beneficial bacteria is important for the establishment and maintenance of the mucosal barrier, thus protecting the neonate from enteric pathogens and local and systemic inflammation. The neonatal microbiome is influenced by infant diet, environment, and the maternal microbiome. Dysbiosis in pregnancy increases the risk of pre-eclampsia, diabetes, infection, preterm labor, and later childhood atopy. Read More

    The influence of breastfeeding in breast-fed infants with atopic dermatitis.
    J Microbiol Immunol Infect 2017 Jun 29. Epub 2017 Jun 29.
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:
    Background: The aim of this study was to evaluate whether breastfeeding should be discontinued for exclusively breast-fed infants with atopic dermatitis (AD).

    Methods: Eighty-seven exclusively breast-fed infants with AD were enrolled in a prospective observational study. The infants were divided into 3 groups: breastfeeding only (BM group), partial breastfeeding and partial partially hydrolyzed whey formula (pHF-W) (Partial group) and pHF-W only (DC group). Read More

    Increased endocan expression in lesional skin and decreased endocan expression in sera in atopic dermatitis.
    J Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
    Endocan is a novel human endothelial cell-specific molecule and is mainly expressed in endothelial cells in various tissues. Endocan has the capacity to inhibit leukocytes binding to the vascular endothelium. It also can promote the angiogenesis alongside vascular endothelial growth factor A. Read More

    The Traditional Chinese Medicine and Relevant Treatment for the Efficacy and Safety of Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Evid Based Complement Alternat Med 2017 21;2017:6026434. Epub 2017 Jun 21.
    Department of Traditional Chinese Medicine, Xijing Hospital Affiliated to Fourth Military Medical University, Xi'an 710032, China.
    Background: Atopic dermatitis (AD) has become a common skin disease that requires systematic and comprehensive treatment to achieve adequate clinical control. Traditional Chinese medicines and related treatments have shown clinical effects for AD in many studies. But the systematic reviews and meta-analyses for them are lacking. Read More

    Early clinical manifestations of Sézary syndrome: A multicenter retrospective cohort study.
    J Am Acad Dermatol 2017 Jul 11. Epub 2017 Jul 11.
    University of Alberta, Edmonton, Canada; Department of Dermatology, University of Copenhagen, Copenhagen, Denmark.
    Background: Classic Sézary syndrome (SS) is defined by erythroderma, generalized lymphadenopathy, and leukemic blood involvement. Clinical observations suggest that SS begins as a nonerythrodermic disease.

    Objective: To describe the early clinical characteristics of patients with SS. Read More

    Systemic therapies in atopic dermatitis: The pipeline.
    Clin Dermatol 2017 Jul - Aug;35(4):387-397. Epub 2017 Mar 23.
    Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:
    Atopic dermatitis (AD), the most prevalent inflammatory skin disease, is characterized by robust T-cell activation. The disease has several subtypes, all having a common T helper type 2 (Th2)/Th22 polarization, but it also displays differential immune skewing, such as increased Th17/interleukin 23 skewing in the skin of intrinsic, Asian, and early pediatric AD patients. Current systemic treatments for moderate to severe AD are largely unsatisfactory, associated with significant adverse effects and low compliance. Read More

    Selected active naturals for atopic dermatitis: Atopic Dermatitis Part 1.
    Clin Dermatol 2017 Jul - Aug;35(4):383-386. Epub 2017 Mar 23.
    Icahn School of Medicine at Mt. Sinai, Mt Sinai St Luke's-Roosevelt Hospital, New York, NY. Electronic address:
    The desire for naturally derived agents is a growing trend for patients, physicians, and pharmaceutical companies. Studies indicate that complementary and alternative medicine is often used by patients and parents of children with atopic dermatitis, not necessarily with beneficial results. A half-dozen natural agents (ie, topical agents: coconut oil, colloidal oatmeal, sunflower oil, mustard oil, glycerin, and oral Chinese herbal therapy) are discussed because they have become popular for their expected activity in the therapy of atopic dermatitis. Read More

    Current and emerging topical therapies for atopic dermatitis.
    Clin Dermatol 2017 Jul - Aug;35(4):375-382. Epub 2017 Mar 24.
    Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, 8010 Frost Street, Suite 602, San Diego, CA 92123; Departments of Dermatology and Pediatrics, University of California, San Diego School of Medicine, 9500 Gillman Drive, La Jolla, CA 92093. Electronic address:
    The pathogenesis of atopic dermatitis (AD) involves epidermal barrier dysfunction and T helper cell type 2 (Th2) lymphocyte-driven inflammation. Cytokines, such as interleukin 4 (IL-4) and IL-13, are important in this reaction. They stimulate B cells to produce immunoglobulin E, causing atopic disease. Read More

    Contact dermatitis considerations in atopic dermatitis.
    Clin Dermatol 2017 Jul - Aug;35(4):367-374. Epub 2017 Apr 22.
    Department of Dermatology, Loma Linda University, Loma Linda, CA. Electronic address:
    Complex immunologic pathways, influenced by both genetic and environment triggers, contribute to the development of atopic dermatitis and allergic contact dermatitis. Suppressing mechanisms between the Th1-driven allergic contact dermatitis and the Th2-driven atopic dermatitis conditions were thought to reduce the simultaneous expression of both; however, recent evidence indicates that pediatric patients with atopic dermatitis are likely to develop clinically relevant positive patch tests and more likely to react to specific allergens, such as lanolin. We review the potential role of skin barrier defects, such as filaggrin mutations and impaired barrier function, including aberrancies in epidermal pH buffering capabilities, which may promote bacterial biofilms and create an environment favoring sensitization. Read More

    Selected comorbidities of atopic dermatitis: Atopy, neuropsychiatric, and musculoskeletal disorders.
    Clin Dermatol 2017 Jul - Aug;35(4):360-366. Epub 2017 Mar 24.
    Departments of Dermatology, Preventive Medicine, and Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL. Electronic address:
    Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with substantial morbidity and quality of life impairment. There are a number of comorbid health problems that occur in patients with AD, aside from the cutaneous signs and symptoms. Chronic pruritus and inflammation can lead to sleep disturbances and mental health symptoms, which are not mutually exclusive. Read More

    Typical and atypical clinical appearance of atopic dermatitis.
    Clin Dermatol 2017 Jul - Aug;35(4):354-359. Epub 2017 Mar 24.
    Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:
    Atopic dermatitis is a complex, systemic inflammatory disorder associated with a variety of clinical features. The original criteria of Hanifin and Rajka include major criteria and a list of about two dozen minor criteria however, even the minor criteria do not include some features of atopic dermatitis noted less commonly but still seen with some frequency. This contribution first reviews the common clinical appearance of atopic dermatitis in infancy, childhood, and adulthood, as well as the less typical appearances, including lichenoid atopic dermatitis; juvenile plantar dermatosis; nummular-type atopic dermatitis; follicular atopic dermatitis; alopecia of atopic dermatitis; eczema coxsackium; and psoriasiform, perineal, and lip licker's dermatitis. Read More

    Current and emerging concepts in atopic dermatitis pathogenesis.
    Clin Dermatol 2017 Jul - Aug;35(4):349-353. Epub 2017 Mar 23.
    Icahn School of Medicine at Mt. Sinai St Luke's-Roosevelt Hospital Center, New York, NY. Electronic address:
    Atopic dermatitis is a common skin disorder with a complex, evolving pathogenesis. Research on the pathogenesis has shifted from focusing primarily on generalized immune system abnormalities in T helper 1/T helper 2 (Th1/Th2) activity to more targeted immune and skin barrier abnormalities contributing to the overall phenotype. Specific signaling pathways recently implicated in atopic dermatitis include production of interleukin (IL) 4 and IL-13, which promote immunoglobulin E production, Th17 and Th22 cells, and production of cytokines. Read More

    The history of atopic dermatitis.
    Clin Dermatol 2017 Jul - Aug;35(4):344-348. Epub 2017 Mar 23.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:
    Fred Wise (1881-1950) and Marion Sulzberger (1895-1983) are often credited with introducing the term atopic dermatitis to dermatology in 1933. This definition was based on atopy, a term first created by Arthur Coca (1875-1959) and Robert Cooke (1880-1960) in 1923, when they recognized an association between allergic rhinitis and asthma. Despite its recent introduction into our medical lexicon, historical precursors of atopic dermatitis date back to at least as early as 69-140 ce. Read More

    IL-4Rα Inhibitor for Atopic Disease.
    Cell 2017 Jul;170(2):222
    Stanford University School of Medicine, Stanford University, Stanford, CA, USA. Electronic address:
    Dupilumab is a fully human IgG4 monoclonal antibody directed against the IL-4Rα subunit of IL-4 and IL-13 receptors. It blocks the signaling pathways of IL-4 and IL-13, key cytokines that drive type 2 inflammatory response. In March 2017, dupilumab was approved for use in the treatment of atopic dermatitis (eczema). Read More

    Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis.
    PLoS One 2017 14;12(7):e0181486. Epub 2017 Jul 14.
    Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, UPRES EA4331, Pôle Biologie Santé, Université de Poitiers, TSA, POITIERS, France.
    Background: Acute-serum Amyloid A (A-SAA), one of the major acute-phase proteins, is mainly produced in the liver but extra-hepatic synthesis involving the skin has been reported. Its expression is regulated by the transcription factors NF-κB, C/EBPβ, STAT3 activated by proinflammatory cytokines.

    Objectives: We investigated A-SAA synthesis by resting and cytokine-activated Normal Human Epidermal Keratinocytes (NHEK), and their inflammatory response to A-SAA stimulation. Read More

    Current insights into the role of human β-defensins in atopic dermatitis.
    Clin Exp Immunol 2017 Jul 14. Epub 2017 Jul 14.
    Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Antimicrobial peptides or host defense peptides are small molecules that display both antimicrobial activities and complex immunomodulatory functions to protect against various diseases. Among these peptides, the human β-defensins (hBDs) are primarily localized in epithelial surfaces, including those of the skin, where they contribute to protective barriers. In atopic dermatitis skin lesions, altered skin barrier and immune dysregulation are believed to be responsible for reduced hBD synthesis. Read More

    Burden of Atopic Dermatitis in the United States: Analysis of Healthcare Claims Data in the Commercial, Medicare, and Medi-Cal Databases.
    Adv Ther 2017 Jul 13. Epub 2017 Jul 13.
    Regeneron Pharmaceuticals, Inc., Tarrytown, NJ, USA.
    Introduction: Comparative data on the burden of atopic dermatitis (AD) in adults relative to the general population are limited. We performed a large-scale evaluation of the burden of disease among US adults with AD relative to matched non-AD controls, encompassing comorbidities, healthcare resource utilization (HCRU), and costs, using healthcare claims data. The impact of AD disease severity on these outcomes was also evaluated. Read More

    Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review.
    Dermatol Ther (Heidelb) 2017 Jul 13. Epub 2017 Jul 13.
    Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
    Introduction: Intense nocturnal pruritus as well as the complex pathophysiology of atopic dermatitis (AD) can severely affect sleep and become a major factor in negatively impacting quality of life in adults. However, much of the literature on sleep disturbance in AD patients is on the pediatric population, and it is not well studied in adults. Furthermore, limited studies are available to guide effective management of sleep disturbance in AD in general. Read More

    Chemical Tattoo Treatment Leading to Systemic Cobalt Hypersensitivity.
    Skinmed 2017 1;15(3):221-222. Epub 2017 Jun 1.
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI;
    An otherwise healthy 36-year-old Caucasian woman, without prior history of atopic dermatitis or eczema, presented to an outside dermatologist with a generalized, severely pruritic eruption involving the entire body except the face. One month previously, she had used a 50% trichloroacetic acid tattoo removal solution on a blue-colored tattoo on the medial aspect of the left ankle. The patient's eruption persisted for 7 months, and after several attempts to slowly taper her prednisone dose, she presented to our institution. Read More

    Dosage Optimization of Nemolizumab Using Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Modeling and Simulation.
    J Clin Pharmacol 2017 Jul 13. Epub 2017 Jul 13.
    Kitasato University School of Medicine, Kitasato Clinical Research Center, Kanagawa, Japan.
    Nemolizumab is a humanized anti-interleukin-31 receptor A monoclonal antibody for treating atopic dermatitis, and it especially improves pruritus. The objective of the simulation study was to optimize the dose regimen using a flat dose. The serum nemolizumab concentration and pruritus visual analog scale as an efficacy end point were modeled using the population analysis approach in 299 patients with atopic dermatitis who received placebo or doses between 0. Read More

    Identification of Unique Proteomic Signatures in Allergic and Non-Allergic Skin Disease.
    Clin Exp Allergy 2017 Jul 13. Epub 2017 Jul 13.
    MedImmune, LLC, Gaithersburg, MD, 20878.
    Background: Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC).

    Objective: Identify unique proteomic signatures to distinguish between inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation. Read More

    The neutrophil-lymphocyte ratio in children with atopic dermatitis: a case-control study.
    Clin Ter 2017 Jul-Aug;168(4):e262-e265
    Fellow of Pediatrics University of Health Sciences, Zeynep Kamil Health Training and Research Center, Department of Pediatrics, Istanbul, Turkey.
    Background: Neutrophil-lymphocyte ratio(NLR) is a novel marker for the evaluation of inflammation and has not been evaluated previously in patients with AD.

    Objective: To investigate the relationship between NLR and the clinical findings of AD.

    Methods: Sixty-six children with AD were included in the study. Read More

    Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis.
    Cell Death Dis 2017 Jul 13;8(7):e2931. Epub 2017 Jul 13.
    Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
    Filaggrin (FLG) mutation is a well-confirmed genetic aberration in atopic dermatitis (AD). Genome-wide association studies on AD have revealed other susceptibility genes, for example, Ovo-like 1 (OVOL1). Nonetheless, the relation between FLG and OVOL1 is unclear. Read More

    Quality of life and psychological disturbances in adults with atopic dermatitis in the Czech Republic.
    J Biol Regul Homeost Agents 2017 07 13;31(2 Suppl. 2). Epub 2017 Jul 13.
    Ist Department of Dermatovenereology, St. Ann´s Faculty Hospital, Brno, Czech Republic.
    Atopic dermatitis (AD) leads to severe psychosocial disturbances that are quite frequently underestimated. We evaluate the quality of life (QoL) of adult patients with AD and their family members using DLQI, B-IPQ, FDLQI questionnaires, observe psychopathological features with CAQ II questionnaire and evaluate correlations between QoL, psychological disturbances and objective/subjective parameters of disease severity. A reduction in QoL has been proven by all questionnaires with statistically significant relationships between all of them. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 07 13;31(2 Suppl. 2). Epub 2017 Jul 13.
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Association among Thyroid Dysfunction, Asthma, Allergic Rhinitis and Eczema in Children with Alopecia Areata.
    Open Access Maced J Med Sci 2017 Jun 11;5(3):305-309. Epub 2017 Jun 11.
    Mazandaran University of Medical Sciences, Sari, Iran.
    Background: Alopecia areata is a non-scarring hair loss, which typically starts quickly. Atopy is one of the possible predisposing risk factors for this condition.

    Aim: This study aimed to evaluate the prevalence of thyroid disease, atopic dermatitis and allergic diseases in children with alopecia areata and compare the results with healthy individuals. Read More

    Prevention and Management of Cow's Milk Allergy in Non-Exclusively Breastfed Infants.
    Nutrients 2017 Jul 10;9(7). Epub 2017 Jul 10.
    Kidz Health Castle, UZ Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.
    Introduction: The prevention and management of cow milk allergy (CMA) is still debated. Since CMA is much less frequent in breastfed infants, breastfeeding should be stimulated. Method: Literature was searched using databases to find original papers and reviews on this topic. Read More

    Inflammatory and Noninflammatory Itch: Implications in Pathophysiology-Directed Treatments.
    Int J Mol Sci 2017 Jul 10;18(7). Epub 2017 Jul 10.
    Department of Dermatology, College of Medicine, Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung 833, Taiwan.
    Itch is the main chief complaint in patients visiting dermatologic clinics and has the ability to deeply impair life quality. Itch results from activation of cutaneous nerve endings by noxious stimuli such as inflammatory mediators, neurotransmitters and neuropeptides, causing itch signal transduction from peripheral skin, through the spinal cord and thalamus, to the brain cortex. Primarily noninflammatory diseases, such as uremic pruritus, cause itch through certain pruritogens in the skin. Read More

    Suboptimal vitamin D status in Korean adolescents: a nationwide study on its prevalence, risk factors including cotinine-verified smoking status and association with atopic dermatitis and asthma.
    BMJ Open 2017 Jul 10;7(7):e016409. Epub 2017 Jul 10.
    Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea.
    Objective: To determine the prevalence and risk factors for suboptimal vitamin D status in Korean adolescents and to assess its relationship with atopic dermatitis (AD) and asthma at a national level.

    Design: This is a cross-sectional study with data from the Korean National Health and Nutrition Examination Survey. Information regarding socioeconomic characteristics, clinical data and environmental factors was collected. Read More

    A 1% Colloidal Oatmeal Cream Alone is Effective in Reducing Symptoms of Mild to Moderate Atopic Dermatitis: Results from Two Clinical Studies.
    J Drugs Dermatol 2017 Jul;16(7):671-676

    BACKGROUND: The epidermal barrier in patients with atopic dermatitis (AD) is deficient in ceramides and cathelicidins. Such epidermal defects may be a trigger for AD, thereby encouraging research toward development of skin-barrier-targeted preventive strategies.

    METHODS: Two single-center, single-arm clinical trials were conducted (study 1, age greater than equal to 8 years and study 2, greater than equal to 10 years) in patients with mild to moderate AD to evaluate the effects of an over-the-counter 1% colloidal oatmeal cream administered for 14 days. Read More

    Severe Infant Rash Resistant to Therapy Due to Zinc Deficiency: A Case Report.
    Pediatr Emerg Care 2017 Jul 11. Epub 2017 Jul 11.
    From the Departments of Paediatrics and Medicine, Schulich School of Medicine, Western University, Children's Hospital, London Health Sciences Centre, London, Ontario, Canada.
    Pediatric skin diseases are a common presenting complaint to emergency medicine physicians but often pose a significant diagnostic challenge. Skin eruptions that are unusually severe for the diagnosis in question, lasting beyond the typical time of resolution, or not responding to conventional therapy should raise concern of a misdiagnosis. We present the case of a severe rash not responding to conventional atopic dermatitis therapy that led to a diagnosis of transient neonatal zinc deficiency. Read More

    The Investigation of the Presence of Mites in Some Served Dry Foodstuffs.
    Turkiye Parazitol Derg 2017 Jun;41(2):92-95
    Department of Microbiology, Giresun University School of Medicine, Giresun, Turkey.
    Objective: Mites are microscopic organisms that lower the quality of life of people who are sensitive to them by causing conditions such as atopic dermatitis, allergic rhinitis, and asthma. These organisms are found in every habitat where humans live. This study was conducted to determine the presence of storage mites in dry food items. Read More

    [Basis for the treatment of eczematous diseases in otorhinolaryngology].
    HNO 2017 Jul 10. Epub 2017 Jul 10.
    Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland.
    According to Coombs and Gell, cell-mediated immune responses belong to type IV reactions and are borne mainly by T lymphocytes. The eliciting allergens are usually so-called haptens. Haptens are substances which develop to whole antigens only by binding to protein carriers. Read More

    Topical treatment with sacran, a sulfated polysaccharide from Aphanothece sacrum, improves corneocyte-derived parameters.
    J Dermatol 2017 Jul 10. Epub 2017 Jul 10.
    Department of Bionics, Advanced Cosmetic Course, Tokyo University of Technology Graduate School, Tokyo, Japan.
    Sacran, a polysaccharide isolated from Aphanothece sacrum (Suizenji-nori) alga, has unique characteristics in terms of its physiological properties and effects on the skin, and has recently become a focus of attention as a novel biomaterial. In a previous study, we reported the unique physical characteristics of sacran, which forms a gel-like film containing water in the presence of polyols. This film resists penetration by water and chemicals. Read More

    A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens.
    J Allergy Clin Immunol 2017 Jul 6. Epub 2017 Jul 6.
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
    Substance P, a neuropeptide associated with itch, atopic dermatitis and inflammation, activates MRGPRX2, a member of the mas-related GPCR family. A specific amino acid in the receptor has been found to be critical for activity. Read More

    Phytotherapeutic potential of natural herbal medicines for the treatment of mild-to-severe atopic dermatitis: A review of human clinical studies.
    Biomed Pharmacother 2017 Jul 4;93:596-608. Epub 2017 Jul 4.
    Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Raiwind Road 55150, Lahore, Pakistan.
    For many decades, natural herbal medicines, polyherbal formulations and/or decoctions of plant-derived materials have widely been accepted as alternative complementary therapies for the treatment, cure or prevention of a wide range of acute and chronic skin diseases including chronic herpes, prurigo, acute and chronic wounds, psoriasis and atopic dermatitis (AD). This review was aimed to summarize and critically discuss about the therapeutic viability and clinical applicability of natural herbal medicines for the treatment of AD in human. The critical analysis of the literature revealed that oral (in the form of capsules, syrup or granules) and/or topical application (alone or in conjunction with wet-wrap dressing and/or acupuncture) of natural herbal medicines exhibit remarkable potential for the treatment of mild-to-severe AD in adults, children, infants and in the pregnant women. Read More

    Several PROMs exist for children with atopic eczema / dermatitis but their validity is largely unknown.
    Pediatr Allergy Immunol 2017 Jul 7. Epub 2017 Jul 7.
    Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Novena, Singapore.
    There is a current paradigm shift to the inclusion of patient-reported outcome measures (PROMs), such as health-related quality of life or functioning, in clinical trials and evaluative healthcare research. Before incorporating PROMS into studies it is important to review their qualities and characteristics objectively. It is for this reason we welcome Soyiri et al. Read More

    House Dust Mite Increases pro-Th2 Cytokines, IL-25 and IL-33 via the Activation of TLR1/6 Signaling.
    J Invest Dermatol 2017 Jul 3. Epub 2017 Jul 3.
    Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:
    House dust mite (HDM) has been implicated in the etiology and exacerbation of atopic dermatitis (AD). Diverse factors contribute to HDM allergenicity through the activation of innate immunity. We investigated whether Dermatophagoides farinae extract (DFE) allergens mediate innate immune activation through specific Toll-like receptors (TLRs) in epidermal keratinocytes, DFE-induced murine AD model and human AD lesions. Read More

    SPINK5 is associated with early-onset and CHI3L1 with late-onset atopic dermatitis.
    Int J Immunogenet 2017 Jul 6. Epub 2017 Jul 6.
    University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
    We have recently showed that filaggrin (FLG) mutations are associated only with early-onset of AD, but not with late-onset of AD. Consequently, other susceptibility genes should receive attention, especially in patients with late-onset of AD. Our aim was to assess the associations between development of AD and the polymorphisms rs2303067 in SPINK5 and rs490928 in CHI3L1. Read More

    Association of atopy and tentative diagnosis of skin cancer - results from occupational skin cancer screenings.
    J Eur Acad Dermatol Venereol 2017 Jul 6. Epub 2017 Jul 6.
    CVderm - German Center for Health Services Research in Dermatology, German Center for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
    Background: The relationship between atopic conditions and carcinoma of the skin has been described inconsistently. Population-based data providing information on atopic diseases as well as on skin-cancer are sparse.

    Objective: To determine the correlation between atopy and prevalence of precanceroses, nonmelanoma skin-cancer and malignant melanoma (MM), while taking into account known risk factors for skin cancer. Read More

    Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis: Progress and Outlook.
    Drugs 2017 Jul 5. Epub 2017 Jul 5.
    Department of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, 8010 Frost Street, Suite 602, San Diego, CA, 92123, USA.
    Phosphodiesterase 4 (PDE4) is a cyclic AMP degrading enzyme in leukocytes. Several decades ago, increased PDE activity was demonstrated in patients with atopic dermatitis (AD). Currently, several PDE4 inhibitors in both topical and oral formulation have been developed to target the inflammatory cascade of AD. Read More

    Probiotics, Prebiotics, and Synbiotics for the Treatment and Prevention of Adult Dermatological Diseases.
    Am J Clin Dermatol 2017 Jul 5. Epub 2017 Jul 5.
    Department of Dermatology, UC Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.
    Background: Probiotic, prebiotic, and synbiotic supplementation is becoming more prevalent nowadays. Clinical studies have demonstrated some of the medical benefits of probiotics, prebiotics, and synbiotics within dermatology but an evidence-based review of their effects in adults is needed.

    Objective: The aim of this study was to identify evidence for the use of supplementation with probiotics, prebiotics, or synbiotics for the prevention and treatment of dermatological diseases in adults. Read More

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