30,642 results match your criteria Dermatitis Atopic


Association study of transition of laboratory marker levels and transition of disease activity of atopic dermatitis patients treated with dupilumab.

Australas J Dermatol 2021 Sep 15. Epub 2021 Sep 15.

Department of Dermatology, Nippon Medical School, Tokyo, Japan.

Background: Dupilumab, a fully human monoclonal antibody that blocks signalling pathways of interleukin (IL)-4 and IL-13, is effective in treating patients with atopic dermatitis (AD). We previously showed that transitions of serum thymus and activation-regulated chemokine (TARC) levels and eosinophil numbers were strongly associated with that of AD activity and that the transitions of serum lactate dehydrogenase (LDH) and immunoglobulin E (IgE) levels were weakly and not associated with that of AD activity, respectively, in patients treated without dupilumab.

Objectives: The purpose of this study was to elucidate whether the association of the transition of laboratory marker levels and transition of disease activity in dupilumab-treated AD patients (present study) was different from that in patients who are not treated with dupilumab (previous study). Read More

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September 2021

Differences in the skin microbial community between patients with active and stable vitiligo based on 16S rRNA gene sequencing.

Australas J Dermatol 2021 Sep 15. Epub 2021 Sep 15.

Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background/objective: Recent studies have described an association between altered skin microbial community and epidemiology of skin diseases, such as vitiligo, atopic dermatitis and psoriasis. In this study, we conducted microbiological analysis on patients at different stages of vitiligo to determine whether the dysbiosis is associated with disease progression.

Methods: To characterise the skin microbes in vitiligo patients, we profiled samples collected from 40 patients with active and stable vitiligo using the Novaseq sequencer. Read More

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September 2021

A qualitative and quantitative comparison of IgE antibody profiles with two multiplex platforms for component resolved diagnostics in allergic patients.

Clin Exp Allergy 2021 Sep 14. Epub 2021 Sep 14.

Clinical and Laboratory Molecular Allergy Unit - IDI - IRCCS, Rome, Italy.

Background: Clinically complex phenotypes require more and more sophisticated and comprehensive diagnostic approaches, able to discriminate genuine sensitizations from cross-reactivity. Interpretative complexity of multiplex diagnostic arrays has somewhat limited their diffusion. This study compares two currently available methods, namely ISAC® test and ALEX2® test. Read More

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September 2021

Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice.

Biosci Rep 2021 Sep 15. Epub 2021 Sep 15.

Wuhan University of Science and Technology, Wuhan, China.

Purpose: The pathological process of atopic dermatitis (AD) progressing into other types of allergic diseases such as asthma and allergic rhinitis during the first several years of life is often referred to as the atopic march. Although the phenomenon of atopic march has been recognized for decades, how asthma stems from AD is still not fully understood, confounding a universal strategy to effectively protect people from the atopic march.

Methods: We established experimental atopic march mice by first inducing allergic dermatitis with 0. Read More

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September 2021

Less-invasive Treatment for Group A Streptococcal Fasciitis with Rapid Antigen Detection Test and Collagen/Gelatin Sponge.

Plast Reconstr Surg Glob Open 2021 Sep 13;9(9):e3793. Epub 2021 Sep 13.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Patients with severe group A Streptococcus (GAS) induced necrotizing soft tissue infection sometimes develop Streptococcal toxic shock syndrome, which is a life-threatening condition with an extremely high fatality rate. Obtaining survival is the most important goal; however, an early diagnosis for debridement surgery and quick granulation formation for skin grafting surgery can better preserve the extremity functions. The patient was a 47-year-old man with a history of atopic dermatitis who presented with GAS-induced necrotizing soft tissue infection in his left lower extremity. Read More

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September 2021

An Infant With Seborrhoeic Dermatitis and Eczema Herpeticum Complicated by a Generalized Infection.

Cureus 2021 Aug 1;13(8):e16818. Epub 2021 Aug 1.

Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Warsaw, POL.

Primary herpes simplex virus 1 (HSV-1) infection in children (beyond the neonatal period) may be asymptomatic or manifest as herpetic gingivostomatitis accompanied by fever and other symptoms. However, severe, health- and life-threatening infection is observed in rare cases, especially in at-risk patients. Children with atopic dermatitis may develop extensive eczema herpeticum (). Read More

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Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis.

Proc Natl Acad Sci U S A 2021 Sep;118(38)

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390;

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin dryness, inflammation, and itch. A major hallmark of AD is an elevation of the immune cytokines IL-4 and IL-13. These cytokines lead to skin barrier disruption and lipid abnormalities in AD, yet the underlying mechanisms are unclear. Read More

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September 2021

House dust mite-derived serine protease upregulates gene expression of interleukin-33 in canine keratinocytes via protease-activated receptor-2.

Vet Dermatol 2021 Sep 14. Epub 2021 Sep 14.

Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 183-8509, Japan.

Background: The involvement of interleukin (IL)-33 produced by keratinocytes has been suggested in the pathogenesis of canine atopic dermatitis (cAD). House dust mite (HDM)-derived proteases induce the production of various cytokines and chemokines in keratinocytes via protease-activated receptor-2 (PAR-2); however, their effects on IL-33 mRNA expression in canine keratinocytes have not been determined.

Hypothesis/objective: To clarify whether HDM-derived proteases induce IL-33 mRNA expression in canine keratinocytes via PAR-2. Read More

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September 2021

The upper epidermis of atopic dogs is altered at the functional and structural levels.

Vet Dermatol 2021 Sep 14. Epub 2021 Sep 14.

Infinity, Inserm, CNRS, UPS, Université de Toulouse, Toulouse, France.

Background: The pathogenesis of human atopic dermatitis (AD) is complex. Like humans, dogs develop spontaneous AD so this species could be a useful model of study. However, AD has been less characterised in dogs than in humans. Read More

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September 2021

Transient and reversible reduction of stratum corneum filaggrin degradation products after allergen challenge in experimentally mite-sensitised atopic dogs.

Vet Dermatol 2021 Sep 14. Epub 2021 Sep 14.

Synelvia, 516 rue Pierre et Marie Curie, Labège, F-31670, France.

Background: A defective skin barrier occurs in dogs with atopic dermatitis, and there is controversy over whether this defect pre-exists, or is secondary to allergic inflammation.

Objectives: To study if an allergen challenge decreases the natural moisturising factor (NMF), which contains the main filaggrin degradation products.

Animals: Four house dust mite (HDM)-sensitised adult atopic dogs from a research colony. Read More

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September 2021

Advances and highlights in biomarkers of allergic diseases.

Allergy 2021 Sep 14. Epub 2021 Sep 14.

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical burden. A large fraction of allergic diseases is characterized by a type 2 immune response involving Th2 cells, type 2 innate lymphoid cells, eosinophils, mast cells, and M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on the disease endotypes, clusters, precision diagnoses, identification of therapeutic targets, and monitoring of treatment efficacies. Read More

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September 2021

Factors Associated with Affective Symptoms and Quality of Life in Patients with Atopic Dermatitis.

Acta Derm Venereol 2021 Sep 13. Epub 2021 Sep 13.

Dermatology Section, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, IT-20100 Milan, Italy.

The aim of this study was to detect demographic and clinical factors associated with affective symptoms and quality of life in patients with severe atopic dermatitis. First, one-way analyses of variance and correlations were performed to compare a large set of qualitative and quantitative clinical variables. Three final multivariable regression models were performed, with depression/anxiety subscales and Dermatology Life Quality Index scores as dependent variables, and the factors that were statistically significant on univariate analyses as independent ones. Read More

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September 2021

Learning from disease registries during a pandemic: Moving toward an international federation of patient registries.

Clin Dermatol 2021 May-Jun;39(3):467-478. Epub 2021 Apr 6.

St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

High-quality dermatology patient registries often require considerable time to develop and produce meaningful data. Development time is influenced by registry complexity and regulatory hurdles that vary significantly nationally and institutionally. The rapid emergence of the coronavirus disease 2019 (COVID-19) global pandemic has challenged health services in an unprecedented manner. Read More

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COVID-19: The Italian experience.

Clin Dermatol 2021 May-Jun;39(3):418-423. Epub 2021 Feb 1.

Dermatology Clinic, University of Catania, Catania, Italy. Electronic address:

Italy was among the world's earliest and most affected countries by coronavirus disease 2019 (COVID-19). We report the Italian experience with the pandemic. The dermatologic community immediately reduced any type of activities to 80% to 90% of outpatient consultations, both in public hospitals and in private offices. Read More

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February 2021

Impact and Associations of Atopic Dermatitis Out-of-Pocket Health Care Expenses in the United States.

Dermatitis 2021 Sep 7. Epub 2021 Sep 7.

From the Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL National Eczema Association, Novato, CA Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC.

Background: Atopic dermatitis (AD) is associated with substantial financial cost, including increased out-of-pocket (OOP) expenses. Associations and impact of OOP cost are poorly understood.

Objective: The aim of the study was to characterize the impact and associations of OOP health care expenses for AD. Read More

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September 2021

Phenol-soluble modulins α are major virulence factors of secretome promoting inflammatory response in human epidermis.

Virulence 2021 12;12(1):2474-2492

Laboratoire Inflammation Tissus Epithéliaux et Cytokines EA 4331, Université De Poitiers, Poitiers, France.

is a skin commensal microorganism commonly colonizing healthy humans. Nevertheless, can also be responsible for cutaneous infections and contribute to flare-up of inflammatory skin diseases such as atopic dermatitis (AD), which is characterized by dysbiosis of the skin microbiota with as the predominant species. However, the role of major virulence factors of this pathogen such as phenol-soluble modulin (PSM) toxins in epidermal inflammation remains poorly understood. Read More

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December 2021

Healthcare Resource Use in Patients with Immune-Mediated Conditions Treated with Targeted Immunomodulators During COVID-19 Pandemic: A Retrospective Claims Analysis.

Adv Ther 2021 Sep 13. Epub 2021 Sep 13.

Department of Dermatology, University of California, San Francisco, CA, USA.

Introduction: The impact of the COVID-19 pandemic on routine medical care may result in altered healthcare resource use in patients with immune-mediated conditions. The aim of this study was to determine the impact of treatment interruptions in patients with and without COVID-19 infections who were treated with targeted immunomodulators (TIMs) in the USA.

Methods: Data from the IBM MarketScan Research Databases were analyzed in patients with immune-mediated conditions from January 1, 2018, through December 31, 2020. Read More

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September 2021

Experience using dupilumab for pediatric atopic dermatitis at a tertiary care c enter: Inadequate response and adverse events.

Pediatr Dermatol 2021 Sep 13. Epub 2021 Sep 13.

Section of Dermatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Background/objective: Dupilumab is highly effective in treating atopic dermatitis (AD). However, some patients experience difficulties with dupilumab therapy, such as inadequate clinical response, failure to achieve long-term disease control, or adverse events (AEs). Our objective is to assess inadequate response and AEs occurring in children on dupilumab therapy for AD. Read More

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September 2021

Pruritus, Pain, and Depression Associated with the Most Common Skin Diseases: Data from the French Study "Objectifs Peau".

Dermatology 2021 Sep 7:1-6. Epub 2021 Sep 7.

Société Française de Dermatologie (SFD), Paris, France.

Background: The prevalence and impact of pruritus, pain, and other sensory symptoms in skin diseases are poorly known.

Objective: To assess the frequency of these symptoms with dermatoses and their association with depression using data from the "Objectifs Peau" survey.

Methods: A representative sample of 20,012 French individuals was created using the usual quota method. Read More

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September 2021

Cutaneous Manifestations of COVID-19: An Experience From Oman.

Cureus 2021 Jul 27;13(7):e16667. Epub 2021 Jul 27.

Dermatology, Al-Nahdha Hospital, Muscat, OMN.

Objectives: To identify the cutaneous manifestations in COVID-19 disease in Oman.

Methods: The study was conducted in two phases with initial cross-sectional data collection with subsequent telemedical investigations of late skin manifestations including confirmed COVID-19 patients evaluated at Al-Nahdha Hospital and local health centers in Muscat from March 22 to June 2, 2020.

Results: The total number of patients included in the study was 374. Read More

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Periostin in Allergy and Inflammation.

Front Immunol 2021 27;12:722170. Epub 2021 Aug 27.

Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan.

Matricellular proteins are involved in the crosstalk between cells and their environment and thus play an important role in allergic and inflammatory reactions. Periostin, a matricellular protein, has several documented and multi-faceted roles in health and disease. It is differentially expressed, usually upregulated, in allergic conditions, a variety of inflammatory diseases as well as in cancer and contributes to the development and progression of these diseases. Read More

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Insights into the Implications of Coexisting Type 2 Inflammatory Diseases.

J Inflamm Res 2021 30;14:4259-4266. Epub 2021 Aug 30.

Department of Head and Neck Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.

The role of type 2 inflammation in the pathogenesis of certain human diseases is an area of active investigation. Certain asthma, atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis phenotypes are characterized by a Th2 predominant inflammatory pathway and are frequently associated with comorbid conditions in patients. The purpose of this article is to review the evidence behind concurrent Th2-mediated diseases and explore how the presence of these comorbid conditions affect patient and disease outcomes. Read More

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From the Cochrane Library: Emollients and Moisturizers for Eczema.

Dermatology 2021 Sep 2:1-3. Epub 2021 Sep 2.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

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September 2021

Atopic dermatitis in adults: a population-based study in Finland.

Int J Dermatol 2021 Sep 12. Epub 2021 Sep 12.

National Institute for Health and Welfare, Helsinki, Finland.

Background: The prevalence of atopic dermatitis (AD) has increased, but studies in adult or elderly populations are sparse.

Methods: We investigated 12-month and lifetime prevalences of AD in the Finnish adult population ≥30 years of age and analyzed living environment factors, socioeconomic factors, lifestyle-related factors, and serum vitamin D levels for their associations with AD in a national health examination survey.

Results: The lifetime prevalence was 21. Read More

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September 2021

Practical Management of Patients with Atopic Dermatitis on Dupilumab.

Dermatol Ther (Heidelb) 2021 Sep 11. Epub 2021 Sep 11.

Division of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Introduction: Dupilumab is approved to treat moderate-to-severe atopic dermatitis (AD) in several countries in patients as young as 6 years of age. Since its approval, practical issues related to the use of dupilumab for AD have arisen, with particular interest in transitioning from current therapies and managing medication overlap, considerations for special populations of patients with AD, and management of potential adverse events.

Methods: This article aims to review the literature addressing several practical management issues related to dupilumab use for AD and to provide a framework for clinical decision-making in these circumstances and sub-populations. Read More

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September 2021

Orengedokuto exerts anti-allergic effects via inhibition of effector T cell activation in a murine model of contact hypersensitivity.

J Nat Med 2021 Sep 12. Epub 2021 Sep 12.

Department of Pharmacognosy, Graduate School of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, Aichi, 468-8503, Japan.

Orengedokuto (OGT) is a Kampo prescription that has been used for the treatment of inflammation, hypertension, gastrointestinal disorders, and liver and cerebrovascular diseases. It is also used for the treatment of skin diseases such as urticaria and atopic dermatitis. We previously studied its anti-allergic effects of OGT on the murine model of 2,4,6-trinitrochlorobenzene (TNCB)-induced contact hypersensitivity (CHS) and demonstrated that it significantly suppresses ear swelling in a dose-dependent manner. Read More

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September 2021

Atopy: A Collection of Comorbid Conditions.

J Allergy Clin Immunol Pract 2021 Sep 9. Epub 2021 Sep 9.

Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Morsani College of Medicine and the James A. Haley Veterans' Hospital, Tampa, FL, USA.

The concept of atopy was initially developed in the first quarter of the twentieth century based on clinical observations without any knowledge of pathogenic mechanisms. Atopy involves a collection of comorbidities which share pathogenic features, and atopic comorbidities affect outcomes of concomitant conditions rather than existing synchronously. The clinical importance of understanding the relationship of these conditions is necessary as the treatment of one condition influences the others, and the development of one leads to or precedes the development of another. Read More

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September 2021

Psychosocial burden of patients with atopic dermatitis at two tertiary referral centres in Malaysia.

Med J Malaysia 2021 Sep;76(5):643-652

Hospital Kuala Lumpur, Department of Dermatology, Kuala Lumpur, Malaysia.

Background: Atopic dermatitis (AD) is a chronic pruritic skin disorder that affects up to 20% of children and 10% of adults. The disease course is unpredictable with periods of exacerbation and remission, thus having a significant impact on the mental health and quality of life (QOL). We evaluated the prevalence of anxiety and depression and their association with disease severity, QOL and their associated factors in adolescents (≥ 13 years old) and adults with AD. Read More

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September 2021

Ophiasis treated with dupilumab.

JAAD Case Rep 2021 Oct 19;16:1-4. Epub 2021 Aug 19.

St. Joseph Mercy Hospital, Ann Arbor, Michigan.

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October 2021