25,966 results match your criteria Dermatitis Atopic


Effectiveness of an antenatal maternal supplementation with prebiotics for preventing atopic dermatitis in high-risk children (the PREGRALL study): protocol for a randomised controlled trial.

BMJ Open 2019 Apr 20;9(4):e024974. Epub 2019 Apr 20.

Department of Dermatology, Centre Hospitalier Universitaire de Nantes, Nantes, Pays de la Loire, France.

Introduction: Atopic dermatitis (AD) is a chronic inflammatory disease affecting 10%-15% of children in Europe. There is a need for new primary preventive therapeutic strategies in at-risk populations. Recent research has indicated that atopic diseases are associated with a disrupted gut microbial 'balance' in early life raising the possibility that interventions which yield optimal patterns of microflora could improve host's health. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024974DOI Listing

Nanoemulsion strategy of pioglitazone for the treatment of skin inflammatory diseases.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.017DOI Listing
April 2019
1 Read

The impact of recent advances in lipidomics and redox lipidomics on dermatological research.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Medical University of Vienna, Austria; Christian Doppler Laboratory for the Biotechnology of Skin Aging, Vienna, Austria.

Dermatological research is a major beneficiary of the rapidly developing advances in lipid analytic technology and of bioinformatic tools which help to decipher and interpret the accumulating big lipid data. At its interface with the environment, the epidermis develops a blend of lipids that constitutes the epidermal lipid barrier, essential for the protection from water loss and entry of dangerous noxae. Apart from their structural role in the barrier, novel intra- and inter-cellular signaling functions of lipids and their oxidation products have been uncovered in most cutaneous cell types over the last decades, and the discovery rate has been boosted by the advent of high resolution and -throughput mass spectrometric techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849193015
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.019DOI Listing
April 2019
1 Read

Evaluating crisaborole as a treatment option for atopic dermatitis.

Expert Opin Pharmacother 2019 Apr 19:1-7. Epub 2019 Apr 19.

d Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.

Introduction: Atopic dermatitis (AD) is a chronic and recurrent disease presenting with eczematous lesions and pruritus. It impacts patient and family quality of life, increases morbidity, and accounts for large health-care expenditures. Although nonpharmacologic, topical, and systemic treatments exist, management of AD remains challenging due to limited treatment options. Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2019.1
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http://dx.doi.org/10.1080/14656566.2019.1604688DOI Listing
April 2019
1 Read

Atopic Eczema: Burden of disease and individual suffering - Results from a large EU-Study in adults.

J Eur Acad Dermatol Venereol 2019 Apr 19. Epub 2019 Apr 19.

European Federation of Allergy and Airway Diseases Patient's Associations, Brussels, Belgium.

Background: Atopic eczema (AE, atopic dermatitis) is one the most common non-communicable inflammatory skin diseases affecting 1-5% of the adult population in Europe with marked impairment in quality of life. In spite of great progress in understanding the pathophysiology of disturbed skin barrier and immune deviation, AE still represents a problem in daily clinical practice. Furthermore, the true impact of AE on individual suffering is often not recognized. Read More

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http://dx.doi.org/10.1111/jdv.15634DOI Listing

Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32-35 weeks.

Eur J Pediatr 2019 Apr 18. Epub 2019 Apr 18.

Paediatric Pneumology Unit, University Clinic Hospital, University of Valencia, Av Blasco Ibáñez, 17, 46010, Valencia, Spain.

Little is known about respiratory morbidity and asthma risk in preterm infants (PTIs) with a gestational age (GA) over 32 weeks. This was a prospective study carried out from birth to 7-8 years, comparing two groups: (a) PTIs (GAs 32 weeks + 1 day to 35 weeks + 0 days, without comorbidities) and (b) full-term infants (FTIs; GA ≥ 37 weeks). Risk and protective factors for bronchiolitis and asthma were identified. Read More

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http://link.springer.com/10.1007/s00431-019-03372-1
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http://dx.doi.org/10.1007/s00431-019-03372-1DOI Listing
April 2019
1 Read

Dead Sea Climatotherapy versus topical steroid treatment for Atopic Dermatitis children: long-term follow-up study.

J Dermatolog Treat 2019 Apr 17:1-19. Epub 2019 Apr 17.

c Dead Sea & Arava Science Center , Israel.

The aim of this study was to compare long-term results of 4 weeks Dead Sea Climatotherapy at the Deutsches Medizinisches Zentrum, Israel to those obtained by classical topical treatment for moderate-to-severe Atopic Dermatitis. Seventy-two children from the Czech Republic were divided into three groups of twenty-four and treated during 3 periods (March 2014, October 2014 and March 2015) with gradually increasing sun exposure during 28 consecutive days. Forty-four children were treated with steroid creams at the Department of Dermatovenereology, Third Faculty of Medicine, Charles University and University Hospital of Kralovske Vinohrady, Prague, Czech Republic. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605138DOI Listing

Anaphylaxis after wheat ingestion in a patient with coeliac disease: two kinds of reactions and the same culprit food.

Eur J Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

In recent years, the role of atopic dermatitis epidermal skin barrier defects in inducing a transcutaneous allergic sensitization is highly debated, possibly explaining why some children with eczema are sensitized to foods they have never eaten. In our specific situation, the association between coeliac disease and wheat allergy might be particularly harmful owing to unavoidable strict food avoidance. We describe the case of a young boy affected by coeliac disease who, after an occasional unexpected ingestion of gluten, experienced a complete anaphylactic reaction characterized by urticarial, labial angioedema, wheezing, and hypotension. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001421DOI Listing
April 2019
2 Reads

A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars.

Clin Ter 2019 Mar-Apr;170(2):e93-e99

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena - Second Opinion Medical Network, Modena (MO), Italy.

Objective: To investigate the therapeutic effect of CBD-ointment administered on severe skin chronic diseases and/or on their outcome scars.

Methods: A spontaneous, anecdotal, retrospective study of 20 patients with two most frequent skin disorders: psoriasis (n: 5 patients), atopic dermatitis (n: 5) and resulting outcome scars (n: 10). The subjects were instructed to administer topical CBD-enriched ointment to lesioned skin areas twice daily for three months treatment. Read More

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http://dx.doi.org/10.7417/CT.2019.2116DOI Listing
April 2019
2 Reads

Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin.

Molecules 2019 Apr 15;24(8). Epub 2019 Apr 15.

Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University, Chungnam 31499, Korea.

Physcion is well known for the treatment of carcinoma. However, the therapeutic effect of physcion on atopic dermatitis (AD) through the inhibition of thymic stromal lymphopoietin (TSLP) level remains largely unknown. In this study, we investigated the anti-AD effect of physcion using HMC-1 cells, splenocytes, and a murine model. Read More

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http://dx.doi.org/10.3390/molecules24081484DOI Listing

Translational drug discovery and development with the use of tissue-relevant biomarkers: towards more physiological relevance and better prediction of clinical efficacy.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Sanofi, Global Head of Immunology Therapeutic Research Area, 640 Memorial Drive, Cambridge, MA, 02139, USA.

Due to the clinical development of drugs such as secukinumab, ustekinumab and dupilumab, major changes have been achieved in the treatment of patients diagnosed with psoriasis and atopic dermatitis. In academia and the pharmaceutical industry, research is increasingly moving towards the development of bi-specific antibodies and multi-specific nanobodies, as there is a compelling need for new treatment modalities for patients suffering from auto-immune or malignant disease. The purpose of this review is to discuss aspects of translational drug development with a particular emphasis on indications such as psoriasis and atopic dermatitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13942
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http://dx.doi.org/10.1111/exd.13942DOI Listing
April 2019
3 Reads

Phenotypic analysis of atopic dermatitis in children aged 1-12 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence.

J Eur Acad Dermatol Venereol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Dermatology, Shanghai Jiaotong University School of Medicine.

Background: Atopic dermatitis (AD) is the most common skin disorder in infancy. However, the diagnosis and definite significance of infantile AD remains a debated issue.

Objective: To analyze the phenotypes of AD in infancy, to establish diagnostic criteria, and to estimate the prevalence of this condition in China. Read More

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http://dx.doi.org/10.1111/jdv.15618DOI Listing
April 2019
2 Reads

The role of Langerhans cells in pathologies of the skin.

Immunol Cell Biol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pathology, Dunedin School of Medicine, University of Otago, P O Box 56, Dunedin, New Zealand.

Langerhans cells (LCs) are epidermal immune cells of myeloid origin. Although these cells were primarily thought to play a defensive role in the skin, evidence now indicates a diverse range of LC-mediated effects including relay of viral antigens in herpes simplex infection, recruitment of eosinophils in atopic dermatitis, and promotion of a Th17 response in Candida infection. LCs may have a protective or suppressive function in pathologies of the skin, with differing functions being driven by the skin milieu. Read More

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http://dx.doi.org/10.1111/imcb.12253DOI Listing
April 2019
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Direct assessment of skin epithelial barrier by electrical impedance spectroscopy.

Allergy 2019 Apr 16. Epub 2019 Apr 16.

Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.

Background: Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants or microbes to enter the tissue and activate the immune response. The aim of this study was to establish a method to directly assess in vivo the epidermal barrier function by electrical impedance (EI) spectroscopy.

Methods: Mice epidermal barrier was damaged by epicutaneous application of proteases and cholera toxin and by tape stripping. Read More

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http://dx.doi.org/10.1111/all.13824DOI Listing
April 2019
2 Reads

Repeat patch testing in a patient with allergic contact dermatitis improved on dupilumab.

JAAD Case Rep 2019 Apr 3;5(4):336-338. Epub 2019 Apr 3.

Department of Dermatology, Stanford University School of Medicine, Redwood City, California.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126193003
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http://dx.doi.org/10.1016/j.jdcr.2019.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447730PMC
April 2019
7 Reads

Immune and Inflammatory Reponses to Skin Infections.

Curr Dermatol Rep 2018 Dec 22;7(4):338-349. Epub 2018 Sep 22.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Purpose Of Review: There have been recent advances in our understanding of cutaneous immune responses to the important human skin pathogen, (). This review will highlight these insights into innate and adaptive immune mechanisms in host defense and cutaneous inflammation in response to skin infections.

Recent Findings: Antimicrobial peptides, pattern recognition receptors and inflammasome activation function in innate immunity as well as T cells and their effector cytokines play a key role in adaptive immunity against skin infections. Read More

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http://dx.doi.org/10.1007/s13671-018-0235-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461387PMC
December 2018
1 Read

A Pharmacological Review on L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities.

J Pharmacopuncture 2019 Mar 31;22(1):7-15. Epub 2019 Mar 31.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

. (PO) or Purslane is an annual grassy plant that is distributed in many parts of the world, especially the tropical and subtropical areas. PO has some pharmacological properties such as analgesic, antibacterial, skeletal muscle-relaxant, wound-healing, anti- inflammatory and a radical scavenger. Read More

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http://dx.doi.org/10.3831/KPI.2019.22.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461301PMC
March 2019
1 Read

Food Allergen Sensitisation Patterns in Omani Patients with Allergic Manifestations.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e483-e488. Epub 2019 Mar 28.

Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.

Objectives: This study aimed to evaluate the relationship between food allergen sensitisation patterns and allergic manifestations in Omani patients and highlight the importance of specific immunoglobulin E (IgE) testing.

Methods: This retrospective study included all patients referred due to allergic manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, from November 2012 to November 2016. Specific IgE blood testing was performed to determine sensitisation to common foods known to cause allergic reactions. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/299
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http://dx.doi.org/10.18295/squmj.2018.18.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443266PMC
November 2018
2 Reads

Testing an ectoin containing emollient for atopic dermatitis.

Curr Pediatr Rev 2019 Apr 15. Epub 2019 Apr 15.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Aim: To describe the methodology in studying patient's acceptability and efficacy of an ectoin containing emollient for atopic dermatitis (AD) Methods: We described the methodology that we used in studying emollients and moisturizers, and patient acceptability of a group of AD patients before and following usage of an ectoin-containing proprietary emollient. These data were also compared with other emollients that we previously reported.

Results: 30 subjects (50% Male, Mean (SD) age: 9. Read More

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http://dx.doi.org/10.2174/1573396315666190415144244DOI Listing
April 2019
1 Read

Apigenin Inhibits IL-31 Cytokine in Human Mast Cell and Mouse Skin Tissues.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do 55069, Korea.

IL-31 is a recently discovered cytokine that is produced not only in T-cells but also in mast cells. It is strongly implicated to play a key role in inflammatory diseases and in the pathogenesis of itch in atopic dermatitis. Apigenin, a flavonoid of plant origin has numerous biological applications. Read More

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https://www.mdpi.com/1420-3049/24/7/1290
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http://dx.doi.org/10.3390/molecules24071290DOI Listing
April 2019
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Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies.

J Clin Med 2019 Apr 2;8(4). Epub 2019 Apr 2.

Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.

Atopic dermatitis (AD) is a long-standing inflammatory skin disease that is highly prevalent worldwide. Multiple factors contribute to AD, with genetics as well as the environment affecting disease development. Although AD shows signs of skin barrier defect and immunological deviation, the mechanism underlying AD is not well understood, and AD treatment is often very difficult. Read More

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http://dx.doi.org/10.3390/jcm8040444DOI Listing

Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis: A Population-based Cohort Study in a California Health Network Between 2011 and 2016.

Pediatr Infect Dis J 2019 Apr 10. Epub 2019 Apr 10.

Department of Pediatric Infectious Diseases, Kaiser Permanente Oakland Medical Center, Oakland, California.

Background: Acute flaccid myelitis (AFM) is defined as an acute onset of limb weakness with longitudinal spinal gray matter lesions. Reporting bias and misdiagnosis confound epidemiologic studies of AFM. We mitigated these confounders by using a large data set to assess AFM incidence, risk factors and outcomes in a fixed population. Read More

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http://dx.doi.org/10.1097/INF.0000000000002276DOI Listing
April 2019
1 Read

Hyponatremia secondary to severe atopic dermatitis in early infancy.

Pediatr Int 2019 Apr 15. Epub 2019 Apr 15.

Department of Allergy, Kanagawa Children's Medical Center, Yokohama, Japan.

Background: Infants with atopic dermatitis who developed hyponatremia and hyperkalemia with raised aldosterone level have been repeatedly described in Japanese domestic literatures. However, similar reports from other countries are scarce.

Methods: Including our experiences, we collected reports of atopic dermatitis complicated with hyponatremia (≤130 mEq/L), written either in English or in Japanese, to delineate the characteristics and to elucidate the pathophysiology of this condition. Read More

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http://dx.doi.org/10.1111/ped.13865DOI Listing
April 2019
3 Reads

Dietary habits in adult Japanese patients with atopic dermatitis.

J Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.

Dietary habits can modulate the pathogenesis of atopic dermatitis. We evaluated these habits in adult Japanese patients with atopic dermatitis using a validated, brief-type self-administered diet history questionnaire and compared the results to those of age- and sex-matched healthy controls. Patients with atopic dermatitis showed higher intakes of carbohydrate and potatoes and lower intakes of alcohol, niacin, meat and oils/fats compared with those of the healthy controls. Read More

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http://dx.doi.org/10.1111/1346-8138.14881DOI Listing
April 2019
3 Reads

Biophysical Measurements and Ultrasonographic Findings in Chronic Dermatitis in Comparison with Uninvolved Skin.

Indian J Dermatol 2019 Mar-Apr;64(2):90-96

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nowadays noninvasive techniques are performed to evaluate the biophysical properties of skin .

Aims: The aim of this study was to evaluate the biophysical and ultrasonographic properties of skin in chronic contact or atopic dermatitis to provide better insight into pathogenesis, diagnosis, and treatment response.

Materials And Methods: The stratum corneum hydration, transepidermal water loss (TEWL), pH, erythema, melanin, sebum, friction, temperature, elasticity parameters (R0, R2, and R5), the thickness and echo-density of epidermis, dermis, and subepidermal low-echogenic band (SLEB) were measured on lesional, perilesional, and symmetrical skin of 22 chronic dermatitis patients. Read More

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http://dx.doi.org/10.4103/ijd.IJD_464_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440184PMC
April 2019
4 Reads

Sodium hypochlorite body wash in the management of Staphylococcus aureus-colonized moderate-to-severe atopic dermatitis in infants, children, and adolescents.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Objectives: A cleansing body wash containing diluted sodium hypochlorite (0.006% NaOCl) was evaluated for management of moderate-to-severe Staphylococcus aureus-colonized, atopic dermatitis in children.

Methods: A 6-week, prospective, open-label study was conducted with 50 evaluable participants (ages 6 months to 17 years) who had moderate-to-severe atopic dermatitis with S aureus skin colonization documented by culture. Read More

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http://dx.doi.org/10.1111/pde.13842DOI Listing
April 2019
1 Read

Identification of blood microRNA alterations in patients with severe active alopecia areata.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Alopecia areata (AA) is a common inflammatory disease characterized by cellular infiltration of T cells targeting the anagen-stage hair follicle. Lack of efficacious treatment for AA may be due to little knowledge about its exact cellular mechanism. Studies have demonstrated that microRNAs (miRNAs) play an important role in the regulation of inflammatory skin diseases such as atopic dermatitis and psoriasis. Read More

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http://dx.doi.org/10.1002/jcb.28700DOI Listing
April 2019
4 Reads

Efficacy and patient opinion of wet-wrap dressings using 0.1% triamcinolone acetonide ointment vs cream in the treatment of pediatric atopic dermatitis: A randomized split-body control study.

Pediatr Dermatol 2019 Apr 14. Epub 2019 Apr 14.

Dell Children's Medical Center, Austin, Texas.

Background: Wet wraps can be an effective means of improving atopic dermatitis (AD). Little research has been done regarding the comparative efficacy of topical steroid vehicles and patient preference.

Objective: This study aimed to compare the efficacy of 0. Read More

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http://dx.doi.org/10.1111/pde.13830DOI Listing

Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):772S-799S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: During the Pregnancy and Birth to 24 Months Project, the USDA and Department of Health and Human Services initiated a review of evidence on diet and health in these populations.

Objectives: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding prior to infant formula introduction, 4) feeding a lower versus higher intensity of human milk to mixed-fed infants, and 5) feeding a higher intensity of human milk by bottle versus breast with food allergies, allergic rhinitis, atopic dermatitis, and asthma.

Methods: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. Read More

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http://dx.doi.org/10.1093/ajcn/nqy283DOI Listing
March 2019
1 Read
6.770 Impact Factor

Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):890S-934S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: Nutrition during infancy and toddlerhood may influence health and disease prevention across the life span. Complementary feeding (CF) starts when human milk or infant formula is complemented by other foods and beverages, beginning during infancy and continuing to age 24 mo.

Objectives: The aim of this study was to describe systematic reviews conducted for the USDA and the Department of Health and Human Services Pregnancy and Birth to 24 Months Project to answer the following question: What is the relationship between the timing of the introduction of complementary foods and beverages (CFBs), or types and amounts of CFBs consumed, and the development of food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis?

Methods: The literature was searched using 4 databases (CINAHL, Cochrane, Embase, PubMed) to identify articles published from January 1980 to February 2017 that met predetermined inclusion criteria. Read More

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http://dx.doi.org/10.1093/ajcn/nqy220DOI Listing
March 2019
3 Reads
6.770 Impact Factor

Soybean fermented with (Cheonggukjang) ameliorate atopic dermatitis-like skin lesion in mice by suppressing infiltration of mast cells and production of IL-31 cytokine in skin lesions.

J Microbiol Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

Department of Health Management, Jeonju University, Jeonju, Jeonbuk 55069, Republic of Korea.

The present study was conducted with the aim to investigate the ameliorative effects of new soybean product (cheonggukjang) fermented with SCGB1 (SFBA) in atopic dermatitis (AD) mouse model. Visual evaluation of AD induction in the mice indicated a remarkable control of SFBA in reducing pathological severity of AD-like skin lesions reported as the SCORAD score of AD clinical symptoms. The results revealed that SFBA reduced dorsal skin and epidermal thickness to a similar extent with prednisolone. Read More

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http://dx.doi.org/10.4014/jmb.1812.12046DOI Listing
April 2019
3 Reads

Adherence to a novel home phototherapy system with integrated features.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Objective: To measure adherence using a novel home UVB phototherapy system designed to promote adherence.

Study Design: A retrospective, observational study conducted to evaluate patients' adherence to a prescribed three-times-per-week treatment protocol using a novel home phototherapy system with integrated features designed to improve adherence.

Methods: Data was collected from 18 psoriasis patients, 27 vitiligo patients, and three atopic dermatitis patients using a novel home phototherapy system under normal use conditions. Read More

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March 2019
1 Read

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling.

Bioorg Med Chem Lett 2019 Apr 4. Epub 2019 Apr 4.

Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor complex, JAK inhibition may offer an alternate small molecule approach to disrupting IL-13 signaling. Herein we demonstrate that JAK1 is likely the isoform most important to IL-13 signaling. Read More

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http://dx.doi.org/10.1016/j.bmcl.2019.04.008DOI Listing

Allergic rhinitis increases the risk of incident panic disorder among young individuals: A nationwide population-based cohort study in Taiwan.

J Affect Disord 2019 Apr 9;252:60-67. Epub 2019 Apr 9.

Tsaotun Psychiatric Center, Ministry of Health and Welfare, 542 No.161, Yu-Pin Rd, Caotun Township, Nantou, Taiwan, R.O.C.. Electronic address:

Background: Studies have reported an association between allergy and panic disorder. However, few studies have explored the relationship between allergic rhinitis and panic disorder. Previous studies were limited by cross-sectional study designs, self-reported symptoms, absence of matched controls, and lack of consideration of the influence of steroid and comorbidities. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.037DOI Listing
April 2019
1 Read

Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Many dermatological diseases have a great impact on the psychological state of patients, like urticaria, psoriasis, atopic dermatitis, and acne vulgaris. Finding a "gold standard" biomarker for chronic stress in acne patients is challenging because of the complex etiology of the chronic stress and its variable manifestations.

Aims: The aim of this study was to evaluate the correlation between serum levels of BDNF and the presence and severity of acne vulgaris and to assess the relationship of this biomarker to both the degree of psychological stress and the quality of patients' lives (QoL). Read More

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http://dx.doi.org/10.1111/jocd.12940DOI Listing
April 2019
5 Reads

52 Week Follow-Up Safety and Effectiveness Results of Dupilumab Treatment of Moderate to Severe Atopic Dermatitis From A Retrospective, Multicentric Series.

Dermatol Ther 2019 Apr 13:e12931. Epub 2019 Apr 13.

Dermatology Unit, Hospital Universitario Virgen del Rocio, Sevilla.

Atopic dermatitis (AD) is a chronic, systemic disease that has a multifactorial etiology, where immune system disorders and epidermal barrier dysfunction are added to the influence of genetic and environmental factors. Dupilumab has been approved by US and EU regulatory agencies in 2017 for the treatment of moderate to severe atopic dermatitis in adult patients who are candidates for systemic treatment. In this short report, we present a retrospective, multicentric study, in which five hospitals in Andalusia, Spain, have taken part. Read More

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http://dx.doi.org/10.1111/dth.12931DOI Listing

Ursolic acid downregulates thymic stromal lymphopoietin through the blockade of intracellular calcium/caspase‑1/NF‑κB signaling cascade in HMC‑1 cells.

Int J Mol Med 2019 Mar 22. Epub 2019 Mar 22.

Department of Food Science and Technology and Research Institute for Basic Science, Hoseo University, Asan, Chungnam 31499, Republic of Korea.

Thymic stromal lymphopoietin (TSLP) plays an important role in allergic disorders, including atopic dermatitis and asthma. Ursolic acid (UA) has various pharmacological properties, such as antioxidant, anti‑inflammatory and anticancer. However, the effect of UA on TSLP regulation has not been fully elucidated. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4144DOI Listing

Indoor cannabis smoke and children's health.

Prev Med Rep 2019 Jun 16;14:100853. Epub 2019 Mar 16.

Center for Behavioral Epidemiology and Community Health (C-BEACH), Graduate School of Public Health, San Diego State University, San Diego, CA, USA.

Cannabis use is increasing and cannabis is typically consumed by smoking. This study explored how indoor secondhand cannabis smoke (SCS) was associated with child health. As part of a larger trial, air particle monitors were placed in 298 homes of families with at least one cigarette smoker and one child under 14 years old in San Diego County, California. Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.100853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441784PMC
June 2019
4 Reads

The effect of Korean Red Ginseng on full-thickness skin wound healing in rats.

J Ginseng Res 2019 Apr 10;43(2):226-235. Epub 2018 Jan 10.

Department of Plastic and Reconstructive Surgery, College of Medicine, Daegu Catholic University, Daegu, Republic of Korea.

Background: is regarded as one of the best compounds for promoting health, and it has been used traditionally as a medicinal herb. Recently, Korean Red Ginseng (RG) has been shown to protect skin from aging and wrinkling; it can also relieve atopic dermatitis and allergy symptoms. This study aimed to evaluate RG's effects on the regeneration of the full-thickness skin wounds in rat. Read More

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http://dx.doi.org/10.1016/j.jgr.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438823PMC

An OMICS-based study of the role of C3dg in keratinocytes: RNA sequencing, antibody-chip array, and bioinformatics approaches.

Int J Biol Macromol 2019 Apr 8. Epub 2019 Apr 8.

College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, 315100, PR China; Department of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 135-710, Republic of Korea; Skin Diseases Research Center, Yangtze Delta Region Institute of Tsinghua University, 705 Yatai Road, Jiaxing 314006, PR China. Electronic address:

Previously, we have identified the C3dg protein as an important player in the pathogenesis of atopic dermatitis (AD). In this study, we aimed to identify critical factors associated with C3dg in human keratinocytes based on high-throughput screening (HTS) approaches. We overexpressed C3dg in HaCaT human keratinocytes and conducted serial HTS studies, including RNA sequencing analysis integrated with antibody-chip arrays and implementation of bioinformatics algorithms (PPI mappings). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193188
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.039DOI Listing
April 2019
5 Reads

Norfloxacin, a Fluoroquinolone Antibiotic, Inhibits Langerhans Cell-Mediated Th1 and Th2 Cell Development.

J Pharm Pharm Sci 2019 Apr 11;22(1):122-130. Epub 2019 Apr 11.

Department of Clinical Immunology, Meiji Pharmaceutical University, Tokyo, Japan.

Background: It is widely acknowledged that Langerhans cells (LCs) play a primary role in the polarization of T helper type 1 (Th1) or T helper type 2 (Th2) immune responses. Our aim was to find fluoroquinolone ("new quinolone") antibiotics that would inhibit LC-mediated Th2 cell development.

Methods: Expression of LC surface molecules was investigated using the reverse transcriptase polymerase chain reaction. Read More

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http://dx.doi.org/10.18433/jpps30335DOI Listing
April 2019
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Update on Protease Activated Receptor 2 in cutaneous barrier, differentiation, tumorigenesis, pigmentation, and role in related dermatologic diseases.

Exp Dermatol 2019 Apr 11. Epub 2019 Apr 11.

Department of Dermatology, College of Medicine, University of Florida, Gainesville, FL, USA.

Protease activated receptor 2 (PAR2) is a transmembrane receptor expressed by multiple tissues, including skin, with rapidly expanding knowledge regarding its roles. In the skin, PAR2 has extensively documented effects in promoting Th2-inflammation and pruritus; and its role in atopic dermatitis continues to be thoroughly studied. Numerous new investigations have shown a more complex range of activities potentially related to dermatologic diseases. Read More

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http://dx.doi.org/10.1111/exd.13936DOI Listing
April 2019
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Validation of five patient-reported outcomes for atopic dermatitis severity in adults.

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Oregon Health & Science University, Portland, OR.

Background: Structured patient-reported outcomes of AD severity are not standardized in clinical practice. We sought to determine the construct validity, internal consistency, cross-cultural validity, floor or ceiling effects of multiple AD severity assessments.

Methods: A cross-sectional, population-based study of 2893 adults, including 602 adults that met a modified UK Diagnostic Criteria for AD. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18002
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http://dx.doi.org/10.1111/bjd.18002DOI Listing
April 2019
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Stopping when knowing: use of snus and nicotine during pregnancy in Scandinavia.

ERJ Open Res 2019 Apr 8;5(2). Epub 2019 Apr 8.

Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

In young women, the use of snus increases in parallel with decreasing smoking rates but the  use in pregnancy is unclear. Our aims were to determine the prevalence of snus use, smoking and other nicotine-containing product use during pregnancy, and to identify predictors for snus use in pregnancy. Prevalence was determined for 2528 women in Norway and Sweden based on the Preventing Atopic Dermatitis and ALLergies (PreventADALL) study, a population-based, mother-child birth cohort. Read More

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http://dx.doi.org/10.1183/23120541.00197-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452060PMC
April 2019
4 Reads

Crisaborole 2% Ointment (Eucrisa) for Atopic Dermatitis

Skin Therapy Lett 2019 Mar;24(2):4-6

Division of Dermatology, University of Alberta, Edmonton, AB, Canada

Atopic dermatitis is a common cutaneous disease with significant morbidity affecting children and adults. The mainstay of atopic dermatitis therapy has typically included emollients, topical corticosteroids, and topical calcineurin inhibitors. Among the newer advances recently introduced is crisaborole (Eucrisa™), a phosphodiesterase type-4 inhibitor (PDE-4) for the treatment of mild moderate atopic dermatitis. Read More

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Predictive factors of response to pulse methylprednisolone therapy in patients with alopecia areata: A follow-up study of 105 Japanese patients.

J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Pulse corticosteroid therapy is effective for alopecia areata (AA) in the early stage. The risk and efficacy of this therapy for patients with several backgrounds, however, remains controversial. To explore the predictive factors of the response and risk factors of this therapy, data from 105 AA patients treated with methylprednisolone (500 mg) i. Read More

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http://dx.doi.org/10.1111/1346-8138.14871DOI Listing
April 2019
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Economic burden of cutaneous infections in children and adults with atopic dermatitis.

Pediatr Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, California.

Background/objectives: Atopic dermatitis (AD) is a chronic, inflammatory disease affecting both children and adults. AD is associated with multiple comorbidities and complications. In particular, AD patients are susceptible to developing cutaneous infections. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pde.13828
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http://dx.doi.org/10.1111/pde.13828DOI Listing
April 2019
2 Reads
1.520 Impact Factor

Tolerability and Efficacy of a Medical Device Repairing Emollient Cream in Children and Adults with Mild to Moderate Atopic Dermatitis.

Dermatol Ther (Heidelb) 2019 Apr 9. Epub 2019 Apr 9.

Clinical Skin Research and Development Center, Hôtel Dieu, Pierre Fabre Dermo-Cosmétique, Toulouse, France.

Introduction: Regular emollient application is recommended for managing atopic dermatitis (AD). Although many emollients are available, only AD-tested medical device repairing emollient creams (MDRECs) can be recommended for treating and preventing AD skin lesions. Here, we evaluated the tolerability and benefit of a new MDREC in an open-label study in infants, young children, and adults with mild to moderate AD. Read More

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http://dx.doi.org/10.1007/s13555-019-0295-0DOI Listing

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children.

Dermatology 2019 Apr 9:1-9. Epub 2019 Apr 9.

Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing, China,

Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Read More

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http://dx.doi.org/10.1159/000496603DOI Listing

Clinical Insights About Topical Treatment of Mild-to-Moderate Pediatric and Adult Atopic Dermatitis.

J Cutan Med Surg 2019 Apr 9:1203475419843108. Epub 2019 Apr 9.

9 Division of Dermatology, BC Children's Hospital; University of British Columbia, Vancouver, Canada.

Atopic dermatitis (AD) is a chronic inflammatory skin condition, also referred to as atopic eczema, that is identified by itching and recurrent eczematous lesions. It often starts in infancy where it affects up to 20% of children but is also highly prevalent in adults. AD inflicts a significant psychosocial burden on patients and their families and increases the risk of other immune-mediated inflammatory conditions, such as asthma and allergic rhinitis, food allergy, and mental health disorders. Read More

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http://dx.doi.org/10.1177/1203475419843108DOI Listing
April 2019
2 Reads