28,110 results match your criteria Dermatitis Atopic


Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis.

J Allergy Clin Immunol 2020 Jul 4. Epub 2020 Jul 4.

Department of Dermatology, University of California San Diego, San Diego, CA, USA; Center for Microbiome Innovation, University of California, San Diego, CA, USA. Electronic address:

Background: S. aureus and S. epidermidis are the most abundant bacteria found on the skin of patients with atopic dermatitis (AD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2020.06.024DOI Listing

Drug survival of dupilumab compared to cyclosporin in moderate-to-severe atopic dermatitis patients.

Dermatol Ther 2020 Jul 7. Epub 2020 Jul 7.

Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy.

Dupilumab and cyclosporin are recommended treatments for moderate-to-severe atopic dermatitis (AD). The objective of this study was to investigate drug survival of dupilumab in comparison with CsA, reasons of drug discontinuation, and predictive parameters of drug survival in daily practice. Retrospective study including patients with moderate-to-severe AD treated with dupilumab or cyclosporin (CsA) from January 1, 2019 to April 30, 2020. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13979DOI Listing

Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate.

Bioorg Med Chem Lett 2020 Aug 1;30(16):127298. Epub 2020 Jun 1.

Open Innovation, Research & Development, Pharmaceuticals, Bayer AG, D-13353 Berlin, Germany.

We report on the discovery of the new clinical candidate BAY 1003803 as glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis. In the course of optimizing the amino alcohol series as a highly potent new non-steroidal lead structure, considerations were made as to how physicochemical properties and safety concerns relate to structural motifs. BAY 1003803 demonstrates strong anti-inflammatory activity in vitro paired with a pharmacokinetic profile suitable for topical application. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2020.127298DOI Listing

Current and emerging treatments targeting the neuroendocrine system for disorders of the skin and its appendages.

Exp Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Dr. August Wolff GmbH & Co. KG Arzneimittel, Bielefeld, Germany.

The skin as a neuroendocrine organ and the role of neuroendocrine signaling in the development of disorders affecting the skin and its appendages has received increasing attention in the last years. Different neuroendocrine systems have been described in the barrier organ skin, including the thyroid system, the hypothalamic-pituitary-adrenal axis, the opioid, the endocannabinoid, the cholinergic, the secosteroidogenic and the serotonergic systems. All of these systems have been implicated in the development of skin diseases, which often have an inflammatory origin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.14145DOI Listing

A moisturizer formulated with glycerol and propylene glycol accelerates the recovery of skin barrier function after experimental disruption in dogs.

Vet Dermatol 2020 Jul 6. Epub 2020 Jul 6.

VetAgro Sup, UP ICE, Université de Lyon, 69280, Marcy l'Étoile, France.

Background: Moisturizers are foundational therapies for human atopic dermatitis. In veterinary medicine, the use of moisturizers has been recommended by an expert committee to alleviate skin dryness that would occur, for example, in canine atopic dermatitis (cAD). However, little is known regarding the effects of moisturizers on the skin barrier. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vde.12859DOI Listing

Evaluation of the clinical efficiency of lokivetmab in client privately owned atopic dogs - multicenter study.

Pol J Vet Sci 2020 Jun;23(2):191-195

"OLWET" Veterinary Clinic, Lubelska 16, 10-404 Olsztyn, Poland.

Atopic dermatitis (AD) is the most frequent allergic disease in dogs. AD can be treated using allergenspecific immunotherapy as well as symptomatic antipruritic treatment including the use of lokivetmab - caninized anti-interleukine-31 antibody.The aim of the study was to evaluate the effectiveness of lokivetmab over 12 weeks of treat-ment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.24425/pjvs.2020.132765DOI Listing

IL‑18 knockout alleviates atopic dermatitis‑like skin lesions induced by MC903 in a mouse model.

Int J Mol Med 2020 Aug 4;46(2):880-888. Epub 2020 Jun 4.

Graduate School, China Medical University, Shenyang, Liaoning 110001, P.R. China.

Interleukin (IL)‑18, a pro‑inflammatory cytokine, plays an important role in a number of skin diseases. The aim of the present study was to investigate the role of IL‑18 in the development of atopic dermatitis (AD). For this purpose, mice were divided into 4 groups (n=5/group) as follows: i) The wild‑type (WT) controls; ii) IL18 knockout (KO) controls; iii) MC903‑treated WT mice; and iv) MC903‑treated KO mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijmm.2020.4630DOI Listing

Does the Gut Microbiota Modulate Host Physiology through Polymicrobial Biofilms?

Microbes Environ 2020 ;35(3)

Institute for Advanced Biosciences, Keio University.

Microbes inhabit various environments, such as soil, water environments, plants, and animals. Humans harbor a complex commensal microbial community in the gastrointestinal tract, which is known as the gut microbiota. The gut microbiota participates not only in various metabolic processes in the human body, it also plays a critical role in host immune responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1264/jsme2.ME20037DOI Listing
January 2020

Establishment of a Mouse Model for Post-Inflammatory Hyperpigmentation.

Pigment Cell Melanoma Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Dermatology, Yamagata University, Faculty of Medicine, Yamagata, Japan.

Post-inflammatory hyperpigmentation (PIH) is a common cutaneous condition that can cause a disfigured appearance. However, the pathophysiology of PIH remains poorly understood, at least in part, because an appropriate animal model for research has not been established. In order to analyze the pathomechanism of PIH, we successfully induced PIH in a hairless version of transgenic mice (hk14-SCF Tg/HRM) that have a human-type epidermis containing melanin by repeated hapten application of 2,4-dinitrofluorobenzene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pcmr.12911DOI Listing

Characterizing Dupilumab Facial Redness in Children and Adolescents: A Single-Institution Retrospective Chart Review.

J Am Acad Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Dermatology, University of Connecticut Health Center, Farmington, CT. 06032.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.06.1003DOI Listing

Review of the use of gentian violet in dermatology practice.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

Objective: To review the use of gentian violet in dermatology.

Design: A comprehensive literature search on gentian violet in dermatology practice was performed through PubMed.

Results: Gentian violet is effective in treating methicillin-resistant Staphylococcus aureus-colonized skin lesions; mean number of days for complete eradication was 9. Read More

View Article

Download full-text PDF

Source

Development of Sézary syndrome following the administration of dupilumab.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

The University of Texas MD Anderson Cancer Center, Houston, TX.

Dupilumab is a monoclonal antibody that inhibits interleukin-4 and interleukin-13 signaling. It is the first biologic agent to demonstrate efficacy in treating moderate-to-severe refractory atopic dermatitis [1, 2]. Although dupilumab provides promise for the treatment of atopic and allergic conditions, clinicians should take into account its novelty and the potential for unexpected adverse events. Read More

View Article

Download full-text PDF

Source

Management of Psychocutaneous Disorders: A Practical Approach for Dermatologists.

Dermatol Ther 2020 Jul 4:e13969. Epub 2020 Jul 4.

Division of Dermatology, Nairi Medical Clinic, Yerevan, Armenia.

Psychodermatology is a growing specialty which is gaining momentum in different parts of the world. It focuses on the connection between skin and psyche. Psychocutaneous conditions are characterized by those disorders where stress is the key element in exacerbating skin conditions or flare ups of dermatoses like psoriasis and atopic dermatitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13969DOI Listing

A patient with CARD14-associated papulosquamous eruptions showing atopic dermatitis-like features.

J Eur Acad Dermatol Venereol 2020 Jul 3. Epub 2020 Jul 3.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Caspase recruitment domain family member 14 (CARD14) is an activator of nuclear factor kappa-light-chain-enhancer in activated B cells (NF-κB) and contributes to inflammatory responses within the epidermis. CARD14 mutations are associated with autoinflammatory keratinization diseases, such as psoriasis and familial pityriasis rubra pilaris (PRP). Recently, Craiglow et al. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16799DOI Listing

Pediatric contact dermatitis: what's new.

Authors:
Idy Tam JiaDe Yu

Curr Opin Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, Massachusetts General Hospital.

Purpose Of Review: Allergic contact dermatitis (ACD) was once thought to be rare in children but recent studies have demonstrated that the prevalence of ACD is common and appears to be increasing in children. Current trends including toys, hobbies, and personal care products may play a role in potentially new allergen exposure or resurgence of certain allergens, making ACD a moving target in children.

Recent Findings: ACD and atopic dermatitis can coexist and certain clinical features can help differentiate ACD from endogenous atopic dermatitis in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOP.0000000000000919DOI Listing

Current and Future Monoclonal Antibodies in the Treatment of Atopic Dermatitis.

Clin Rev Allergy Immunol 2020 Jul 2. Epub 2020 Jul 2.

Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Atopic dermatitis is a common immunologic skin disease. Mild atopic dermatitis can be managed with emollients and topical therapies such as low potency topical steroids, which have a favorable safety profile. Severe atopic dermatitis, in contrast, is a challenging disease to treat. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12016-020-08802-9DOI Listing

Topical Application of ASN008, a Permanently-charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset and Long Duration of Action in a Mouse Model of Pruritus.

J Pharmacol Exp Ther 2020 Jul 2. Epub 2020 Jul 2.

UC San Diego

The sensation of pruritus, or itch, is associated with a variety of skin and medical disorders. Itch is transmitted through afferent C-fibers, and sodium channels play a key role in the transmission process. Local anesthetics, which block sodium channels, are used topically to treat itch, but generally have a short duration of action and are not selective for afferent nerves underlying the itch sensation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.120.265074DOI Listing

Unique skin abnormality in patients with peanut allergy but no atopic dermatitis.

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Department of Pediatrics, National Jewish Health, 1400 Jackson St, Denver, CO 80206; Department of Pediatrics, University of Colorado, 12700 E 19(th) Pl, Denver, CO 80045. Electronic address:

Background: The nonlesional skin of atopic dermatitis (AD) children with peanut allergy (PA) is associated with increased transepidermal water loss (TEWL), low urocanic (UCA) and pyroglutamic (PCA) acids (filaggrin [FLG] breakdown products), and reduced ratio of esterified ω-hydroxy fatty acid sphingosine ceramides (EOS-CER) to non-hydroxy fatty acid sphingosine ceramides (NS-CER) in the skin. The skin barrier of PA without AD (AD-PA+) subjects has not been studied.

Objective: To explore whether AD-PA+ is associated with skin barrier abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2020.06.015DOI Listing

Atopic dermatitis displays stable and dynamic skin transcriptome signatures.

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, Venereology, and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Background: Skin transcriptome studies in atopic dermatitis (AD) showed broad dysregulation as well as "improvement" under therapy. These observations were mainly made in trials and based on microarray data.

Objectives: To explore the skin transcriptome and the impact of systemic treatment in patients of the TREATgermany registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2020.06.012DOI Listing

High adherence and low dropout rate in a virtual clinical study of atopic dermatitis through weekly reward-based personalized genetic lifestyle reports.

PLoS One 2020 2;15(7):e0235500. Epub 2020 Jul 2.

LEO Innovation Lab, Copenhagen, Denmark.

Introduction: Clinical trials often suffer from significant recruitment barriers, poor adherence, and dropouts, which increase costs and negatively affect trial outcomes. The aim of this study was to examine whether making it virtual and reward-based would enable nationwide recruitment, identify patients with variable disease severity, achieve high adherence, and reduce dropouts.

Methods: In a siteless, virtual feasibility study, individuals with atopic dermatitis (AD) were recruited online. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235500PLOS

Can moderate-intensity aerobic exercise ameliorateatopic dermatitis?

Exp Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Allergy Immunology Center, Korea University, Seoul, Korea.

It has been shown that aerobic exercise improves atopic dermatitis (AD), although the mechanism is not clear. Here, we propose a hypothesis that moderate-intensity aerobic exercise improvesAD ina mouse model through modulating allergic inflammation.The DNCB-treated mouse model for eczemawere divided into 3 groups: 1) not subjected to aerobic exercise, 2) subjected to continuous aerobic exercise and, 3) subjected to accumulated aerobic exercise. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.14138DOI Listing

Increased level of high mobility group box 1 in the serum and skin in patients with generalized pustular psoriasis.

J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

High-mobility group box 1 (HMGB-1) is a highly abundant pro-inflammatory protein associated with the pathogenesis of inflammatory and autoimmune diseases. HMGB-1 expression level increases in patients with psoriasis vulgaris (PV). However, HMGB-1 expression in patients with generalized pustular psoriasis (GPP) is unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15467DOI Listing

A study into the drug dupilumab in Japanese adults with moderate-to-severe atopic dermatitis.

Authors:

Br J Dermatol 2020 Jul;183(1):e4-e30

Atopic dermatitis (AD), a long-lasting skin disease characterized by intense itching and dry, red, swollen and cracked skin, affects between 2% and 10% of Japanese adults. In Japan, patients with moderate-to-severe or very severe AD have limited treatment options, most with unwanted side effects. There is a need for therapies that provide safe and effective long-term control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.19174DOI Listing

Eyelid Disorders in Ophthalmology Practice: Results from a Large International Epidemiological Study in Eleven Countries.

Ophthalmol Ther 2020 Jul 1. Epub 2020 Jul 1.

Kharkiv National Medical University, Kharkiv, Ukraine.

Purpose: Anecdotal evidence suggests that eyelid disorders are common, although estimates of prevalence vary. The current study determines the prevalence of eyelid disorders, meibomian gland dysfunction (MGD) and related diseases (specifically ocular surface disease) in a population of patients presenting for routine ophthalmologic consultations.

Methods: This cross-sectional epidemiologic survey evaluated patients presenting for routine ophthalmic visits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40123-020-00268-4DOI Listing

Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities.

Int J Mol Sci 2020 Jun 29;21(13). Epub 2020 Jun 29.

Department of Medicinal Biosciences, Research Institute for Biomedical & Health Science, College of Biomedical and Health Science, Konkuk University, 268 Chungwon-daero Chungju-si 27478, Korea.

Apigenin (4',5,7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin analyzed its effect on histamine release in the 1950s. Since then, anti-mutation and antitumor properties of apigenin have been widely reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21134620DOI Listing

Treatments for Childhood Atopic Dermatitis: an Update on Emerging Therapies.

Authors:
Chia-Yu Chu

Clin Rev Allergy Immunol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan South Road, Taipei, 10002, Taiwan.

Atopic dermatitis (AD) is generally considered a T helper type 2-dominated disease. Pediatric AD is usually less severe than adult AD, but it may present as moderate to severe lesions that are inadequately managed by current modalities including emollients/moisturizers, topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and even systemic immunosuppressants (such as cyclosporine, azathioprine, methotrexate, and mycophenolate mofetil). In addition, systemic immunosuppressants are often not recommended for childhood AD by the current guidelines due to their toxicities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12016-020-08799-1DOI Listing

Costs and Treatment Patterns Among Patients with Atopic Dermatitis Using Advanced Therapies in the United States: Analysis of a Retrospective Claims Database.

Dermatol Ther (Heidelb) 2020 Jun 30. Epub 2020 Jun 30.

Pfizer Inc., Collegeville, PA, USA.

Introduction: For many, atopic dermatitis (AD) is not adequately controlled with topical regimens. This analysis examined treatment using advanced therapies and associated costs.

Methods: The IQVIA Health Plan Claims data set was analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13555-020-00413-8DOI Listing

IL-33/13 Axis and IL-4/31 Axis Play Distinct Roles in Inflammatory Process and Itch in Psoriasis and Atopic Dermatitis.

Clin Cosmet Investig Dermatol 2020 19;13:419-424. Epub 2020 Jun 19.

Department of Internal Medicine, Nephrology Division, Jordan University of Science and Technology, Irbid, Jordan.

Background: Pruritus is the most common symptom in patients with skin disease. Psoriasis and atopic dermatitis are clinically distinct inflammatory diseases. Interleukins are cytokines which play key roles in inflammatory signaling pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CCID.S257647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310969PMC

4-month-old boy coinfected with COVID-19 and adenovirus.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Pediatrics, Rush University Medical Center, Chicago, Illinois, United States.

A 4-month-old boy with a history of muscular ventricular septal defect and atopic dermatitis presented with decreased oral intake, loose stools, stuffy nose, mild cough and diaphoresis. The patient had an in-home exposure to COVID-19. The initial respiratory pathogen panel was positive for adenovirus, consistent with his symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2020-236264DOI Listing

Meeting Report: 68 Montagna Symposium on the Biology of Skin: "Decoding Complex Skin Diseases: Integrating Genetics, Genomics, and Disease Biology".

J Invest Dermatol 2020 Jun 27. Epub 2020 Jun 27.

Department of Dermatology, University of Michigan, Ann Arbor, MI; Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI.

The 68 Montagna Symposium on the Biology of the Skin was held from October 10-14, 2019, at Salishan Lodge in Gleneden Beach, Oregon. The theme of the meeting was "Decoding Complex Skin Diseases: Integrating Genetics, Genomics, and Disease Biology". The meeting emphasized integration of multiple themes and disciplines to better understand some of the most common skin diseases, ranging from psoriasis to alopecia areata to vitiligo to lupus erythematosus to atopic dermatitis and food allergy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2020.06.010DOI Listing

Dupilumab in pediatric dermatology.

J Dermatolog Treat 2020 Jul 7:1-3. Epub 2020 Jul 7.

Dermatology Department, University of Patras, Greece, University General Hospital of Patras, Rio, Greece.

Background: Dupilumab is a monoclonal antibody that targets the interleukin (IL)-4 receptor alpha subunit of the IL-4 and IL-13 receptor. This novel agent has received a license for the treatment of moderate-to-severe atopic dermatitis in patients aged ≥12 years. However, data on the dupilumab use in the pediatric population are still extremely limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2020.1789049DOI Listing

Petroleum jelly baths: A tip for easy emollient application.

Pediatr Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.

Petroleum jelly has long been a favorite treatment option of dermatologists for atopic dermatitis, despite complaints of "greasiness" by patients and their parents. Here, we describe a simple application method that effectively traps moisture against the skin while leaving behind only a thin layer of product, thus eliminating the "greasiness" associated with petroleum jelly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.14256DOI Listing

Cyclosporin in Dermatology: A Practical Compendium.

Dermatol Ther 2020 Jun 30:e13934. Epub 2020 Jun 30.

Department of Medicine, The Aga Khan University Hospital, Karachi-Pakistan.

Cyclosporine A belongs to calcineurin inhibitor family, which has the ability to selectively suppress T-cells. Owing to its immune-modulatory effects, it had been in use for graft versus host diseases and organ transplant rejection for many years, but in dermatology, it was first approved for use in 1997 in the treatment of psoriasis. Other off label indications for skin diseases includes atopic dermatitis, chronic spontaneous urticaria, lichen planus, pyoderma gangrenosum, alopecia areata, granuloma annulare and several others. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13934DOI Listing

Retrospective Study of Dupilumab Treatment for Moderate to Severe Atopic Dermatitis in Korea: Efficacy and Safety of Dupilumab in Real-World Practice.

J Clin Med 2020 Jun 24;9(6). Epub 2020 Jun 24.

Department of Dermatology, National Medical Center, Seoul 04564, Korea.

Among biological agents for the treatment of atopic dermatitis (AD), dupilumab is a front-runner. Although many studies have been conducted on the real-world use of dupilumab, the sample size is often small and data is primarily on Western people. Therefore, we investigated the efficacy and safety of dupilumab in patients with moderate-to-severe AD in Korea. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9061982DOI Listing

Neuroinflammatory Gene Expression Pattern Is Similar between Allergic Rhinitis and Atopic Dermatitis but Distinct from Atopic Asthma.

Biomed Res Int 2020 10;2020:7196981. Epub 2020 Jun 10.

Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland.

Methods: In the study, we included 86 children diagnosed with atopic asthma ( = 25), allergic rhinitis ( = 20), and atopic dermatitis ( = 20) and healthy control subjects ( = 21) of Caucasian origin from the Polish population. The blood leukocyte expression of 31 genes involved in neuroinflammatory response (neurotrophins, their receptors, neuropeptides, and histamine signaling pathway) was analysed using TaqMan low-density arrays. The relative expression of selected proteins from plasma was done using TaqMan Protein Assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/7196981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305544PMC

Long-Term Outcomes of Pediatric Enterovirus Infection in Taiwan: A Population-Based Cohort Study.

Front Pediatr 2020 12;8:285. Epub 2020 Jun 12.

Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan.

The major burden of diseases in childhood has shifted from infectious diseases to chronic health conditions in recent decades. Although the rates of infectious diseases have decreased, the incidence of chronic diseases stemming from infectious agents continues to grow. Enterovirus is a major infectious disease of childhood and has been linked to numerous chronic diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2020.00285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303813PMC

Therapeutic Effects of Saline Groundwater Solution Baths on Atopic Dermatitis: A Pilot Study.

Evid Based Complement Alternat Med 2020 10;2020:8303716. Epub 2020 Jun 10.

Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi 13520, Republic of Korea.

Background: Saline groundwater, collected from the east coast of Korea, has been shown to have protective effects against 2,4-dinitrochlorobenzene- (DNCB-) induced atopic dermatitis-like skin lesions in the murine model.

Objectives: To determine the effects of saline groundwater solution baths as a treatment of mild-to-moderate atopic dermatitis.

Methods: Twenty-four subjects with mild-to-moderate atopic dermatitis were instructed to take a bath in saline groundwater solution for 20 minutes per day for two weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/8303716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303733PMC

Circadian Regulation of the Biology of Allergic Disease: Clock Disruption Can Promote Allergy.

Authors:
Atsuhito Nakao

Front Immunol 2020 12;11:1237. Epub 2020 Jun 12.

Department of Immunology, Faculty of Medicine, University of Yamanashi, Kofu, Japan.

Allergic diseases such as allergic rhinitis, asthma, atopic dermatitis, and food allergy are characterized by epithelial barrier dysfunction and deregulated immune responses. Components of the circadian clock interact with critical elements of epithelial barrier function and immune responses, and regulate the biological processes on a 24-h cycle at steady state. This may represent an anticipatory defense response to day-night fluctuation of attack by noxious stimuli such as pathogens in the environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.01237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304491PMC

The Dichotomous Responses Driven by β-Defensins.

Front Immunol 2020 12;11:1176. Epub 2020 Jun 12.

Centre for Inflammation Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, Scotland.

Defensins are short, rapidly evolving, cationic antimicrobial host defence peptides with a repertoire of functions, still incompletely realised, that extends beyond direct microbial killing. They are released or secreted at epithelial surfaces, and in some cases, from immune cells in response to infection and inflammation. Defensins have been described as endogenous alarmins, alerting the body to danger and responding to inflammatory signals by promoting both local innate and adaptive systemic immune responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.01176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304343PMC

Extracorporeal Photopheresis: A Case of Immunotherapy Ahead of Its Time.

Transfus Med Hemother 2020 Jun 27;47(3):226-235. Epub 2020 May 27.

Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria.

Extracorporeal photopheresis (ECP) is a cell-based immunotherapy that involves the reinfusion of autologous leukocytes after exposure to psoralen and UVA. The treatment has been used for over 30 years, at first on patients with cutaneous T-cell lymphoma (CTCL) and later for the management of patients with graft-versus-host disease (GvHD), sclerosing disorders, atopic dermatitis, and other diseases that may share the common driving factor of a pathogenic T-cell clone or clones in blood circulation. Patients with clinical improvement mount an antigen-specific immune response that may have tolerance traits in the case of GvHD or anticlonal cytotoxic characteristics in the case of CTCL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000508479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315210PMC

Regulation and dysregulation of CARD14 signalling and its physiological consequences in inflammatory skin disease.

Authors:
Mark Mellett

Cell Immunol 2020 Jun 13;354:104147. Epub 2020 Jun 13.

Department of Dermatology, University Hospital of Zürich, Zürich, Switzerland. Electronic address:

CARD14 is a scaffold molecule predominantly expressed in keratinocytes and genetic variants in the CARD14 gene confer an increased risk of inflammatory skin disease. Due to its association with common skin diseases psoriasis and atopic dermatitis, the biological function of CARD14 is of relevant interest to human health. CARD14 recruits BCL10 and MALT1 to form the CARD-BCL10-MALT1 complex, which modulates NF-κB and MAPK signalling pathways, yet little is known about how CARD14 is regulated or activated in the context of the innate immune response and in chronic inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellimm.2020.104147DOI Listing

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?

Pharmacol Ther 2020 Jun 24:107618. Epub 2020 Jun 24.

University of Lille, Inserm, U995 - LIRIC - Lille Inflammation Research International Center, ICPAL, 3 rue du Professeur Laguesse, BP-83, F-59006 Lille, France.

Safe and efficient drugs to combat the current COVID-19 pandemic are urgently needed. In this context, we have analyzed the anti-coronavirus potential of the natural product glycyrrhizic acid (GLR), a drug used to treat liver diseases (including viral hepatitis) and specific cutaneous inflammation (such as atopic dermatitis) in some countries. The properties of GLR and its primary active metabolite glycyrrhetinic acid are presented and discussed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2020.107618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311916PMC

Pruritus Characteristics in Severe Atopic Dermatitis in Adult Patients.

Adv Exp Med Biol 2020 Jun 27. Epub 2020 Jun 27.

Department of Physiotherapy, Opole Medical School, Opole, Poland.

Atopic dermatitis (AD) is classified as a most common inflammatory skin disease. The condition is characterized by recurrent eczematous lesions and intense pruritus or itch, a hallmark of AD. The aim of this study was to identify the provoking factors of itch in severe AD adult patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/5584_2020_548DOI Listing

The clinical impact of cross-reactions between allergens on allergic skin diseases.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):374-380

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

Purpose Of Review: The route of allergen sensing via the skin appears to influence the immune system towards mounting a type 2 response, especially in genetically predisposed individuals. Allergens recognized this way may derive from microbial, animal, food, or other plant sources and trigger atopic dermatitis. Allergens can be grouped into families depending on their structure and function, harboring significant structural and sequence similarities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACI.0000000000000650DOI Listing

The role of IL-17, IL-23 and IL-31, IL-33 in allergic skin diseases.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):367-373

Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Purpose Of Review: Allergic skin diseases such as urticaria, atopic dermatitis and allergic contact dermatitis are among the most common skin diseases with severe socioeconomic consequences. The pathogenesis of allergic skin diseases is complex. This review provides an overview of cytocines IL-17, IL-23, IL-31 and IL-33. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACI.0000000000000658DOI Listing

Family functioning according to clusters of family management styles in Korean families of children with chronic atopic disease: A cross-sectional study.

Int J Nurs Stud 2020 Jun 6;109:103674. Epub 2020 Jun 6.

College of Nursing, Korea University, 145 Anam-ro, Seongbuk-Gu, Seoul 02841, South Korea. Electronic address:

Background: Chronic allergic diseases in children are often linked with behavioral problems, poor daily living, negative perceptions of health, and low life satisfaction.

Objectives: This study aimed to propose clusters of family management styles in the Korean families of children with chronic atopic disease, including allergic asthma, atopic dermatitis, and/or allergic rhinitis and examine the level of family functioning according to these clusters.

Design: Cross-sectional study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijnurstu.2020.103674DOI Listing

A knock-down cell-based study for the functional analysis of chloride intracellular channel 1 (CLIC1): Integrated proteomics and microarray study.

Protein Pept Lett 2020 Jun 25. Epub 2020 Jun 25.

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon. South Korea.

Background: Previously, we detected that chloride intracellular channel 1 (CLIC1) was involved in the pathogenesis of atopic dermatitis (AD).

Objective: In this study, we aimed to use high-throughput screening (HTS) approaches to identify critical factors associated with the function of CLIC1 in knock-down cells.

Methods: We down-regulated CLIC1 in human A549 cells via siRNA and then conducted serial HTS studies, including proteomics integrated with a microarray and the implementation of bioinformatics algorithms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/0929866527666200625204650DOI Listing

Sleep and Asthma Outcomes in Urban Children: Does Atopic Dermatitis Increase Risk?

Ann Allergy Asthma Immunol 2020 Jun 22. Epub 2020 Jun 22.

Professor (Research), Department of Psychiatry and Human Behavior and Department of Pediatrics, The Warren Alpert Medical School of Brown University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2020.06.029DOI Listing