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    1 OF 474

    What is the role of Staphylococcus aureus and herpes virus infections in the pathogenesis of atopic dermatitis?
    Future Microbiol 2017 Oct 20. Epub 2017 Oct 20.
    Paulo de Goes Microbiology Institute, Federal University Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Atopic dermatitis (AD) is a chronic, relapsing disease. Genetic, environmental and immunological factors are involved in its pathophysiology. Individuals with AD have an increased predisposition to colonization and/or infection of the skin by various pathogens, especially Staphylococcus aureus and herpes simplex virus. Read More

    Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes.
    Food Chem Toxicol 2017 Oct 16. Epub 2017 Oct 16.
    Cell & Matrix Research Center, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:
    We previously reported the inhibitory effect of chrysin, a natural flavonoid plentifully contained in propolis, vegetables and fruits, on the mast cell-mediated allergic reaction. In this study, we evaluated the effect of chrysin on atopic dermatitis (AD) and defined underlying mechanisms of action. We used an AD model in BALB/c mice by the repeated local exposure of 2,4-dinitrochlorobenzene (DNCB) and house dust mite (Dermatophagoides farinae extract, DFE) to the ears. Read More

    Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
    Br J Dermatol 2017 Oct 19. Epub 2017 Oct 19.
    Northwestern Medicine Multidisciplinary Eczema Center, Chicago, IL, USA.
    Background: Multiple patient-reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, e.g. Read More

    Interleukin 31 and skin diseases: A systematic review.
    Allergy Asthma Proc 2017 Nov;38(6):401-408
    Background: Although the pathophysiology of pruritus has been extensively studied in recent years, with many resultant advancements, management of pruritus is still enigmatic, particularly in chronic cutaneous diseases, such as atopic dermatitis, chronic urticaria, allergic contact dermatitis, cutaneous T-cell lymphoma, and uremic pruritus. The recent finding of the involvement of interleukin (IL) 31 in the pathogenesis of chronic pruritus has provided a novel approach to the management of chronic inflammatory skin disorders. The present report provided an in-depth overview of the role of IL-31 in chronic skin diseases and the possible diagnostic and therapeutic applications in the management of these diseases. Read More

    [Frequency of skin reactivity to food allergens in allergic patients].
    Rev Alerg Mex 2017 Jul-Sep;64(3):291-297
    Hospital Universitario de Puebla, Servicio de Alergia e Inmunología Clínica, Puebla, Puebla, México.
    Background: Food allergy is deemed to have a worldwide prevalence ranging from 2 to 10 %.

    Objective: To determine the frequency of skin reactivity to food allergens by age groups.

    Methods: Cross-sectional, descriptive, prolective, observational study. Read More

    Clinical impact in the real life of guidelines recommendations for atopic dermatitis in a tropical population (TECCEMA cohort).
    Rev Alerg Mex 2017 Jul-Sep;64(3):260-269
    Universidad de Antioquia, IPS Universitaria. Grupo de Alergia Clínica y Experimental. Medellín, Antioquia, Colombia.
    Background: Real-life impact of guidelines for the management of atopic dermatitis has been poorly studied.

    Objective: To assess atopic dermatitis clinical control in residents of a tropical area managed according to international consensuses.

    Methods: Prospective study with a 24-month follow-up. Read More

    Unique profile of antimicrobial peptides expression in polymorphic light eruption lesions compared to healthy skin, atopic dermatitis, and psoriasis.
    Photodermatol Photoimmunol Photomed 2017 Oct 16. Epub 2017 Oct 16.
    Research Unit for Photodermatology, Medical University of Graz, Graz, Austria.
    Background: Polymorphic light eruption (PLE) has been attributed to type IV, most likely delayed-type hypersensitivity response (adaptive immunity) but little is known on innate immunity, especially antimicrobial peptides (AMPs) in the disease. Abnormalities in AMP expression have been linked to pathological skin conditions such as atopic dermatitis (AD) and psoriasis.

    Methods: AMP profiling was done in PLE skin samples (n,12) compared with that of healthy (n,13), atopic (n,6) and psoriatic skin (n,6). Read More

    Feeding filaggrin: effects of l-histidine supplementation in atopic dermatitis.
    Clin Cosmet Investig Dermatol 2017 5;10:403-411. Epub 2017 Oct 5.
    Dermatology Centre, Division of Musculoskeletal and Dermatological Sciences, Salford Royal NHS Foundation Trust, University of Manchester, Manchester.
    Atopic dermatitis (AD), also known as eczema, is one of the most common chronic skin conditions worldwide, affecting up to 16% of children and 10% of adults. It is incurable and has significant psychosocial and economic impacts on the affected individuals. AD etiology has been linked to deficiencies in the skin barrier protein, filaggrin. Read More

    Maternal Stress During Pregnancy and Allergic Diseases in Children During the First Year of Life.
    Respir Care 2017 Oct 17. Epub 2017 Oct 17.
    Department of Pediatrics and Allergy, Medical University of Lodz, Copernicus Memorial Hospital in Lodz, Poland.
    Background: Many recent studies indicate that prenatal maternal distress increases the risk of allergic diseases in children. The mechanisms that favor it are still unclear.

    Objectives: We aimed to assess the association between exposure to different kinds of prenatal stress and the occurrence of atopic dermatitis, food allergy, wheezing, and recurrent respiratory tract infections in children. Read More

    Non-nutritional use of breast milk.
    Postepy Hig Med Dosw (Online) 2017 Oct;71(0):860-866
    Zakład Biofizyki i Fizjologii Człowieka, Warszawski Uniwersytet Medyczny.
    Mammals milk, in addition to nutrients, contains many biologically active substances including immunoglobulins, growth factors, cytokines, acute phase proteins, and antimicrobial and antiviral proteins. Thanks to its unique composition, for hundreds of years it is used in post-natal care, treatment of wounds, as well as to fight bacterial and viral infections. The discovery of stem cells and HAMLET complex in breast milk resulted in increased interest in human breast milk as a natural medicine. Read More

    TWEAK/Fn14 Activation Participates in Skin Inflammation.
    Mediators Inflamm 2017 6;2017:6746870. Epub 2017 Sep 6.
    Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
    Tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) participates in multiple biological activities via binding to its sole receptor-fibroblast growth factor-inducible 14 (Fn14). The TWEAK/Fn14 signaling pathway is activated in skin inflammation and modulates the inflammatory responses of keratinocytes by activating nuclear factor-κB signals and enhancing the production of several cytokines, including interleukins, monocyte chemotactic protein-1, RANTES (regulated on activation, normal T cell expressed and secreted), and interferon gamma-induced protein 10. Mild or transient TWEAK/Fn14 activation contributes to tissular repair and regeneration while excessive or persistent TWEAK/Fn14 signals may lead to severe inflammatory infiltration and tissue damage. Read More

    Nasal Cytology as a Marker of Atopy in Children.
    Dis Markers 2017 5;2017:4159251. Epub 2017 Sep 5.
    Department of Pediatrics, Pediatric Nephrology and Allergology, Central Clinical Hospital of the Ministry of Defence, Military Institute of Medicine, Warsaw, Poland.
    The aim of this study was to evaluate the cytological picture of nasal mucosa in children with atopic diseases and to determine the diagnostic value of the test for the diagnosis of atopic diseases. The study included 140 children from 4 months to 17 years old. Among children with a history of atopy, there were 30 children with atopic dermatitis, 30 children with asthma, and 46 children with allergic rhinitis. Read More

    Plasma miR-155, miR-203, and miR-205 are Biomarkers for Monitoring of Primary Cutaneous T-Cell Lymphomas.
    Int J Mol Sci 2017 Oct 15;18(10). Epub 2017 Oct 15.
    BIOCEV, First Faculty of Medicine, Charles University, 25250 Vestec, Czech Republic.
    Primary cutaneous T-cell lymphomas (CTCL) affect the skin and tend to transform and spread. CTCL involves primarily the Mycosis fungoides (MF) and more aggressive Sezary syndrome (SS). Oncogenic microRNAs (miRs) are stable epigenetic inhibitors often deregulated in the tumour and detectable as biomarkers in non-cellular fractions of peripheral blood. Read More

    Identification of atopic dermatitis phenotypes with good responses to probiotics (Lactobacillus plantarum CJLP133) in children.
    Benef Microbes 2017 Oct;8(5):755-761
    1 Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnamgu, Seoul 06351, Republic of Korea.
    The therapeutic effect of probiotics in atopic dermatitis (AD) remains controversial and varies according to the individual patient. We aimed to identify a population of AD patients with a good clinical response to probiotic treatment. We recruited 76 children with a median age of 7. Read More

    Interleukin-13 in Asthma and Other Eosinophilic Disorders.
    Front Med (Lausanne) 2017 19;4:139. Epub 2017 Sep 19.
    Immunology Discovery, Genentech, Inc., South San Francisco, CA, United States.
    Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse set of underlying pathologies. Rather than being viewed as a single disease entity, asthma is now thought of as a clinical syndrome with the involvement of multiple pathological mechanisms. Read More

    Successful transdermal allergen delivery and allergen-specific immunotherapy using biodegradable microneedle patches.
    Biomaterials 2017 Oct 4;150:38-48. Epub 2017 Oct 4.
    Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:
    Allergen-specific immunotherapy (SIT) is an effective treatment modality for allergic diseases such as atopic dermatitis (AD). However, frequent visits over a 3-year period as well as looming adverse events tend to discourage patient compliance. Therefore, a more convenient, effective, and safe method of SIT is needed. Read More

    A systematic review of safety and efficacy of systemic corticosteroids in atopic dermatitis.
    J Am Acad Dermatol 2017 Oct 12. Epub 2017 Oct 12.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, IL USA. Electronic address:
    Background: Systemic corticosteroids are often used to treat atopic dermatitis (AD). However, few studies assessed the safety and efficacy of systemic corticosteroids in AD.

    Objective: To systematically review the literature on efficacy and safety of systemic corticosteroid use (oral, intramuscular, intravenous) in AD. Read More

    Changing perspectives in atopic dermatitis.
    Allergol Immunopathol (Madr) 2017 Oct 11. Epub 2017 Oct 11.
    Department of Allergology, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain. Electronic address:
    Atopic dermatitis (AD) is a multifaceted disease that involves a complex interplay between the skin and the immune system. The course of the disease depends strongly on the genetic background of the patient and on yet poorly-defined environmental factors. Changes in lifestyle could be behind the dramatic rise in the prevalence of AD across continents; including hygienic conditions, food, social habits, skin microbiome or exposure to a number of allergens. Read More

    Balneotherapeutic effects of high mineral spring water on the atopic dermatitis-like inflammation in hairless mice via immunomodulation and redox balance.
    BMC Complement Altern Med 2017 Oct 13;17(1):481. Epub 2017 Oct 13.
    Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon, 26426, Republic of Korea.
    Background: Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of children and adults worldwide. Drugs used to treat these inflammatory diseases include anti-histamines, corticosteroids and calcineurin inhibitors but these drugs have their limitations such as adverse effects with their long-term usage. Thus, researcher's interest in several alternative and complementary therapies are continually growing and balneotherapy is one of these approaches. Read More

    Hypochlorous acid is anti-pruritic and anti-inflammatory in a mouse model of atopic dermatitis.
    Clin Exp Allergy 2017 Oct 13. Epub 2017 Oct 13.
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, NC, USA.
    Background: It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of itch in human patients with atopic dermatitis, however the specific anti-pruritic mechanism of action remains unclear.

    Objective: To confirm itch relief and reduction of lesions in a mouse model of atopic dermatitis and to elucidate possible HOCl's mode of action.

    Methods: In this study, the effects of topical administration of HOCl hydrogel (0. Read More

    Effect of isoliquiritigenin for the treatment of atopic dermatitis-like skin lesions in mice.
    Arch Dermatol Res 2017 Oct 12. Epub 2017 Oct 12.
    The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266001, China.
    Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized with high heterogeneity. Recent studies have suggested that it is driven by both terminal keratinocyte differentiation defects and type 2 immune responses. The mainstay steroid topical therapy has severe side effect and new treatment is in demand. Read More

    Association between Stress and the HPA Axis in the Atopic Dermatitis.
    Int J Mol Sci 2017 Oct 12;18(10). Epub 2017 Oct 12.
    Dermatology Service & Translational Research Unit (UIT), Hospital General Universitario de Ciudad Real, Ciudad Real 13005, Spain.
    The hypothalamic-pituitary-adrenal (HPA) axis is one of the body's neuroendocrine networks that responds to psychological stress (PS). In the skin, there exists a peripheral HPA axis similar to the central axis. Glucocorticoids (GCs) are key effector molecules of the HPA axis and are essential for cutaneous homeostasis. Read More

    Respiratory comorbidity in South African children with atopic dermatitis.
    S Afr Med J 2017 Sep 22;107(10):904-909. Epub 2017 Sep 22.
    Division of Allergology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, Cape Town, and Faculty of Health Sciences, University of Cape Town, South Africa.
    Background: Atopic dermatitis (AD) is an early and important step in the propagation of the allergic march, enhancing food and respiratory allergies via epicutaneous sensitisation to allergens.

    Objectives: To determine the prevalence and patterns of aeroallergen sensitisation, asthma and allergic rhinitis in South African (SA) children with AD.

    Methods: This was a prospective, observational study in a paediatric university hospital in Cape Town, SA. Read More

    Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis.
    Benef Microbes 2017 Oct 12;8(5):833-840. Epub 2017 Oct 12.
    3 Food Technology Department, Faculty of Engineering, Bina Nusantara University, Alam Sutera, Serpong, Tangerang, Indonesia.
    Lactobacillus plantarum IS-10506 is a novel probiotic isolated from dadih, an Indonesian traditional fermented buffalo milk. It's in vitro and in vivo probiotic properties have been assessed. Probiotic function has been shown in vivo by the suppression of allergic reactions in BALB/c mice through the action of T-regulatory cells cytokines by balancing Th1 and Th2 immune response. Read More

    Ratio of Klebsiella/Bifidobacterium in early life correlates with later development of paediatric allergy.
    Benef Microbes 2017 Oct 12;8(5):681-695. Epub 2017 Oct 12.
    1 Nutricia Research, Danone Nutricia Early Life Nutrition, Matrix Building #05-01B, 30 Biopolis Street, 138671 Singapore, Singapore.
    Several studies have reported that intestinal microbial colonisation patterns differ between non-allergic and allergic infants. However, the microbial signature underlying the pathogenesis of allergies remains unclear. We aim to gain insight into the development of the intestinal microbiota of healthy infants and infants who develop allergy in early life, and identify potential microbiota biomarkers of later allergic disease. Read More

    Atopic dermatitis: the new frontier.
    Med J Aust 2017 Oct;207(8):351-356
    Royal North Shore Hospital, Sydney, NSW.
    Atopic dermatitis (AD) is the most common inflammatory skin condition in adults and children. AD is a chronic disease that has a considerable negative impact on the quality of life of patients and their families. Most cases of AD may be effectively treated with topical therapies that are directed at decreasing cutaneous inflammation and alleviating pruritus. Read More

    Anti-inflammatory effect of collagen tripeptide in atopic dermatitis.
    J Dermatol Sci 2017 Sep 28. Epub 2017 Sep 28.
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
    Background: Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease in which type 2 allergic inflammation plays an important role. Collagen tripeptide (CTP) is a functional collagen fraction with a high content of Gly-X-Y tripeptides.

    Objective: To examine the effect of CTP on inflammation in AD. Read More

    The burden of atopic dermatitis in US adults: Health care resource utilization data from the 2013 National Health and Wellness Survey.
    J Am Acad Dermatol 2017 Oct 7. Epub 2017 Oct 7.
    Department of Dermatology and Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
    Background: There is a lack of data on the burden of atopic dermatitis (AD) in adults relative to the general population.

    Objective: To characterize the AD burden in adult patients relative to both matched non-AD controls and matched patients with psoriasis in terms of comorbidities, health care resource utilization (HCRU), and costs.

    Methods: Adults (≥18 years) who self-reported a diagnosis of AD or psoriasis and adult non-AD controls were identified from the 2013 US National Health and Wellness Survey. Read More

    Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment.
    J Vis Exp 2017 Sep 27(127). Epub 2017 Sep 27.
    Neuroscience Research Institute & Department of Physiology, College of Medicine, Korea University;
    Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Read More

    Vitamin D and the Skin: An Update for Dermatologists.
    Am J Clin Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Dermatology, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
    Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Read More

    A Practical Guide About Tattooing in Patients with Chronic Skin Disorders and Other Medical Conditions.
    Am J Clin Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Dermatology, AZ Sint-Jan Brugge-Oostende AV, 8000, Brugge, Belgium.
    With tattoos becoming increasingly mainstream, dermatologists are more and more often consulted by patients who are considering getting an ornamental, cosmetic, or even a medical tattoo, and who subsequently ask for advice. This includes not only patients with chronic skin diseases such as psoriasis or atopic dermatitis but also patients with other medical conditions. This review first explores the reasons why patients may want to get a tattoo and aims to offer some key information to dermatologists on what they should know about tattooing and the main risks associated with this procedure. Read More

    Recurrent wheeze and its relationship with lung function and airway inflammation in preschool children: a cross-sectional study in South Korea.
    BMJ Open 2017 Oct 8;7(10):e018010. Epub 2017 Oct 8.
    Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Background: Relationship between recurrent wheeze and airway function and inflammation in preschool children is not fully known.

    Objective: To investigate the relationship between recurrent wheeze and airway inflammation, lung function, airway hyper-reactivity (AHR) and atopy in preschool children.

    Design: Observational study, comparing forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid-forced expiratory flow (FEF25%-75%), dose-response slope (DRS), exhaled nitric oxide (eNO) and atopic sensitisation between children with recurrent wheeze and those without. Read More

    Dupilumab for the treatment of asthma.
    Expert Opin Biol Ther 2017 Oct 8:1-8. Epub 2017 Oct 8.
    a Department of Medical and Surgical Sciences , University "Magna Græcia" of Catanzaro , Catanzaro , Italy.
    Introduction: Dupilumab is a fully human IgG4 monoclonal antibody directed against the α subunit of the interleukin (IL)-4 receptor (IL-4Rα). Since the activation of IL-4Rα is utilized by both IL-4 and IL-13 to mediate their pathophysiological effects, dupilumab behaves as a dual antagonist of these two sister cytokines, which blocks IL-4/IL-13-dependent signal transduction. Areas covered: Herein, the authors review the cellular and molecular pathways activated by IL-4 and IL-13, which are relevant to asthma pathobiology. Read More

    Anti‑inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model.
    Mol Med Rep 2017 Oct 3. Epub 2017 Oct 3.
    Department of Pharmacology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
    Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. The present study investigated the effects of Amomum xanthioides extract (AXE) on AD‑like skin inflammation using a Dermatophagoides farinae extract (DFE) and 2,4‑dinitrochlorobenzene (DNCB)‑induced mouse AD model. Hematoxylin and eosin staining results demonstrated that repeated DFE/DNCB exposure markedly increased the thickening of the dermis and epidermis, in addition to the infiltration of eosinophils and mast cells. Read More

    P38/ERK MAPK signaling pathways are involved in the regulation of filaggrin and involucrin by IL‑17.
    Mol Med Rep 2017 Oct 2. Epub 2017 Oct 2.
    Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China.
    Atopic dermatitis (AD) is characterized by a defective skin barrier, which increases the penetration of allergens and pathogens through the skin. The role of interleukin (IL)‑17, a pro‑inflammatory cytokine, in the pathogenesis of AD remains to be elucidated. The present study aimed to examine the effects of IL‑17 on skin barrier proteins in the HaCaT cell line. Read More

    Efficacy and tolerability of liposomal polyvinylpyrrolidone-iodine hydrogel for the localized treatment of chronic infective, inflammatory, dermatoses: an uncontrolled pilot study.
    Clin Cosmet Investig Dermatol 2017 22;10:373-384. Epub 2017 Sep 22.
    Mundipharma Research GmbH & Co.KG, Limburg (Lahn), Germany.
    Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinyl-pyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of PVP-iodine with the drug delivery and moisturizing properties of liposomes. We investigated the utility of liposomal PVP-iodine to treat infective dermatoses. Read More

    Epicutaneous sensitization with ovalbumin, staphylococcal enterotoxin B and vitamin D analogue induces 
atopic dermatitis in mice.
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Sep;42(9):1023-1029
    Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
    Objective: To illuminate a method for establishment of a cost-efficient atopic dermatitis (AD) mouse model by topical application of ovalbumin (OVA), super-antigen staphylococcal enterotoxin B (SEB), and calcipotriene ointment (CO) on the back of BALB/c mice.
 Methods: Experimental mice were topically treated with OVA/SEB or OVA/SEB/CO every other day during 15 days of induction. Clinical alterations on the skin area were monitored every other day. Read More

    Risk of Infection in Patients with Atopic Dermatitis Treated with Dupilumab: A Meta-Analysis of Randomized Controlled Trials.
    J Am Acad Dermatol 2017 Oct 4. Epub 2017 Oct 4.
    Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, RI, United States. Electronic address:
    Background: Atopic dermatitis (AD) is characterized by skin barrier defects, Th2 activation, and increased risk for cutaneous and extracutaneous infections. In clinical trials, dupilumab appeared to decrease rates of skin infections in AD.

    Objective: We aimed to determine the impact of dupilumab on rates of skin and other infections in patients with moderate-to-severe AD. Read More

    CRD and beyond: multivariable regression models to predict severity of hazelnut allergy.
    Allergy 2017 Oct 7. Epub 2017 Oct 7.
    Allergy Unit, Department of Dermatology, University Hospital Zürich, Switzerland.
    Background: Component-resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention has been given to combining them with clinical factors in predicting severity.

    Aim: To analyze associations between severity and sensitization patterns, patient characteristics and clinical history, and to develop models to improve predictive accuracy. Read More

    Investigation of the correlation of serum IL-31 with severity of dermatitis in an experimental model of canine atopic dermatitis using beagle dogs.
    Vet Dermatol 2017 Oct 6. Epub 2017 Oct 6.
    UF Comparative Dermatology Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Avenue, Gainesville, FL, 32608, USA.
    Background: IL-31 is a cytokine that is believed to play an important role in atopic dermatitis (AD). IL-31 levels positively correlate with disease severity in children with AD. Currently, there is no study that has investigated such a correlation in atopic dogs. Read More

    Anti-IgE Treatment for Disorders Other Than Asthma.
    Front Med (Lausanne) 2017 21;4:152. Epub 2017 Sep 21.
    Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
    Immunoglobulin E (IgE) plays a key role in the pathogenesis of many allergic diseases. Thus, IgE-mediated immunologic pathways are an attractive target for intervention in allergic diseases. Omalizumab is a recombinant humanized monoclonal antibody that binds IgE and has been used treat allergic asthma for over a decade. Read More

    Overview of atopic dermatitis.
    Am J Manag Care 2017 Jun;23(8 Suppl):S115-S123
    Atopic dermatitis (AD), also known as atopic eczema, is a chronic relapsing inflammatory skin condition. Incidence of AD has increased 2- to 3-fold in industrialized nations, impacting approximately 15% to 20% of children and 1% to 3% of adults worldwide. AD has a wide-ranging impact on a patient's quality of life and the burden from direct and indirect costs (approximately $37. Read More

    Dust mite induces multiple polar T-cell axes in human skin.
    Clin Exp Allergy 2017 Oct 4. Epub 2017 Oct 4.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY, USA.
    Background: House dust mite/HDM atopy patch test/APT elicits positive reactions in a high fraction of atopic dermatitis/AD and healthy individuals. Experimental systems for new-onset/chronic AD are needed to support rapid therapeutic development, particularly since animal models representing human AD are lacking. While HDM APT has been considered to simulate AD, its suitability to model AD's emerging Th2/Th22 phenotype with Th1 and Th17 components is unknown. Read More

    Rev Paul Pediatr 2017 Jan-Mar;35(1):5-10. Epub 2017 Feb 20.
    Universidade do Estado do Pará (UEPA), Belém, PA, Brasil.
    Objective: To evaluate the impact of atopic dermatitis on the quality of life of pediatric patients in the age group of 5-16 years, and their parents, assisted at the Dermatology Department of Universidade do Estado do Pará in 2015.

    Methods: A cross-sectional study including 51 patients and their guardians, to whom two questionnaires about the quality of life were applied, the Children's Dermatology Life Quality Index (CDLQI) and the Dermatitis Family Impact (DFI). To evaluate the severity of the disease, the researchers applied the Severity Scoring of Atopic Dermatitis (SCORAD) index. Read More

    Rev Paul Pediatr 2017 Jul-Sep;35(3):244-251. Epub 2017 Jul 13.
    Universidade Federal de Pernambuco, Recife, PE, Brasil.
    Objective: To translate, adapt and validate the Itch Severity Scale to a Brazilian version (ISS-Ped) in order to measure the severity of pruritus in children and adolescents with atopic dermatitis.

    Methods: This is a methodological study of validation of an instrument following recommended protocols. The translated version was evaluated by a group of experts including one professional with experience in instrument validation, three English teachers, one linguistics teacher and seven allergists. Read More

    Increased attention-deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use.
    Allergy 2017 Oct 4. Epub 2017 Oct 4.
    Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, TU, Dresden, Germany.
    Background: Epidemiologic evidence indicates a relevant association between atopic dermatitis (AD) and attention-deficit/hyperactivity disorder (ADHD). Underlying mechanisms and ways to best identify subgroups of AD patients at risk for ADHD are poorly understood.

    Aims Of The Study: To compare sociodemographic, clinical, and psychosocial characteristics of children with AD, ADHD, comorbid AD/ADHD, and age-matched healthy controls. Read More

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