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    Burden of skin pain in atopic dermatitis.
    Ann Allergy Asthma Immunol 2017 Dec;119(6):548-552.e3
    Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Department of Preventive Medicine, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Department of Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois. Electronic address:
    Background: Atopic dermatitis (AD) is associated with itch, skin inflammation and barrier disruption, and scratching, all of which may be associated with skin pain.

    Objective: To characterize the patient burden of skin pain in AD.

    Methods: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist. Read More

    Children with atopic dermatitis may have unacknowledged contact allergies contributing to their skin symptoms.
    J Eur Acad Dermatol Venereol 2017 Dec 9. Epub 2017 Dec 9.
    Department of Dermatology and Venereology, Aarhus University Hospital.
    Background: Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in AD facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in children with atopic dermatitis.

    Objective: To determine the prevalence of contact allergy in Danish children with atopic dermatitis and explore the problem of unacknowledged allergies maintaining or aggravating the skin symptoms. Read More

    Virtual screening for inhibitors of the human TSLP:TSLPR interaction.
    Sci Rep 2017 Dec 8;7(1):17211. Epub 2017 Dec 8.
    Laboratory of Medicinal Chemistry, University of Antwerp, 2610, Wilrijk, Belgium.
    The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis. TSLP forms a ternary complex with the TSLP receptor (TSLPR) and the interleukin-7-receptor subunit alpha (IL-7Rα), thereby activating a signaling cascade that culminates in the release of pro-inflammatory mediators. In this study, we conducted an in silico characterization of the TSLP:TSLPR complex to investigate the drugability of this complex. Read More

    Ann Dermatol Venereol 2017 Jan;144 Suppl 1:S42-S49
    Pierre Fabre Dermo-Cosmétique, Centre de recherche & développement Pierre Fabre, 3, avenue Hubert-Curien, 31035 Toulouse cedex, France.
    Atopic dermatitis (AD) is an inflammatory and pruritic dermatosis of multifactorial origin. Topical steroids are the first line treatment for severe AD however alternatives treatment are increasingly needed. A biological concentrate was elaborated from culture of an Avène aquatic microflora isolate namely Aquaphilus dolomiae. Read More

    Ann Dermatol Venereol 2017 Jan;144 Suppl 1:S35-S41
    Sorbonne Universités, UPMC Université Paris 6, CNRS, Laboratoire de biodiversité et biotechnologies microbiennes (LBBM), observatoire océanologique, avenue Pierre Fabre, F-66650 Banyuls-sur-Mer, France; Pierre Fabre dermo-cosmétique, Centre de recherche & développement Pierre Fabre, 3, avenue Hubert-Curien, BP13562, F-31035 Toulouse, France.
    Human hosts a large number of microorganisms that constitute its microbiome and the vast majority of them are very useful and even essentials. The human microbiome is a complex ecosystem where live populations of transient or resident microorganisms. The process of co-development or co-adaptation played a major role in the establishment of indigenous communities and help explain the dominance of positive interactions (commensal, symbiotic or mutualistic) in the human-microorganism relationship. Read More

    Ann Dermatol Venereol 2017 Jan;144 Suppl 1:S27-S34
    Responsable médical, Laboratoires Dermatologiques Avène, Pierre Fabre Dermo-Cosmétique, 81506 Lavaur, France.
    Atopic dermatitis (AD) is the most frequent disease treated at the Avène hydrotherapy center. Children represent a large part of the population due to the high prevalence of AD in early childhood. Avène thermal spring water (ATSW) has been known for its therapeutic effects since the middle of the 18th century. Read More

    Ann Dermatol Venereol 2017 Jan;144 Suppl 1:S2-S13
    Clinique dermatologique, hôpitaux universitaires et université de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg Cedex, France. Electronic address:
    Atopic dermatitis has been described under many names before the XXth century, and first illustrated in the early XIXth century. This article presents historical images from the first volumes of Robert Willan to the Pratique dermatologique, the first encyclopedy published in 1900. Many accurate clinical descriptions of the disease can be found in the early treaties of dermatology, including the one published by Thomas Carrere in 1740. Read More

    Ann Dermatol Venereol 2017 Jan;144 Suppl 1:S14-S20
    Service de dermatologie, CHU de Nantes, 1, place Alexis-Ricordeau, 44000 Nantes, France.
    Atopic dermatitis is a multifactorial disease due to a combination of genetic and environmental factors. The pathophysiological mechanisms involved in AD are multiple: innate functional abnormality in the skin barrier partly linked to mutations of the filaggrin, a major structural protein of the skin; and genes involved in innate and adaptive immunity; Finally, the model of the hygiene theory has been clarified in recent years: environmental factors alter the diversity of skin and digestive microbiomes, and this diversity seems to play a major role in the development of atopy. Read More

    Physiological effects of brominated flame retardants on NC/Nga mice.
    Immunopharmacol Immunotoxicol 2017 Dec 8:1-5. Epub 2017 Dec 8.
    a Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering , Kyoto University , Kyoto , Japan.
    Purpose: Brominated flame retardants (BFRs) are used as an additive or reactive components in various materials. Regarding their health concerns, their immunotoxicity have not been clarified yet.

    Materials And Methods: In the current study, we examined the effects of systemic exposure to two types of BFRs, DE71 and DE79, on pathophysiologic traits of murine atopic dermatitis (AD). Read More

    Oxymatrine Sensitizes the HaCaT Cells to the IFN-γ Pathway and Downregulates MDC, ICAM-1, and SOCS1 by Activating p38, JNK, and Akt.
    Inflammation 2017 Dec 7. Epub 2017 Dec 7.
    Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
    Decreased interferon (IFN)-γ levels and increased levels of macrophage-derived chemokine (MDC) and intercellular adhesion molecule (ICAM)-1 are known to be involved in allergic skin diseases, such as eczema and atopic dermatitis. Activation of the IFN-γ and its downstream interleukin-12 (IL-12) pathway can correct these diseases. Suppressor of cytokine signaling 1 (SOCS1) is a cytokine signaling inhibitor that blocks downstream pathways of IFN-γ by blocking the mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) signaling pathways. Read More

    Emerging Treatment Options in Atopic Dermatitis: Topical Therapies.
    Dermatology 2017 Dec 8. Epub 2017 Dec 8.
    Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.
    Atopic dermatitis is a chronic inflammatory skin disorder affecting children and adults, with the majority presenting mild to moderate disease severity. The use of topical corticosteroids (TCSs) in combination with emollients has been the mainstay for treating mild to moderate atopic dermatitis since the 1950s, and as a supplement to systemic treatment in severe disease. However, while very effective, TCSs are often accompanied by poor adherence due to corticophobia (fear of using corticosteroids in patients or doctors), unwanted side effects, and in some cases insufficient clinical response. Read More

    Economic value of using partially hydrolysed infant formula for risk reduction of atopic dermatitis in high-risk infants not exclusively breastfed in Singapore.
    Singapore Med J 2017 Dec 7. Epub 2017 Dec 7.
    Nestlé Research Center, Lausanne, Switzerland.
    Introduction: Previous trials have demonstrated reductions in atopic dermatitis (AD) incidence when healthy, high-risk, non-exclusively breastfed infants were fed until four months of age with 100% whey-based partially hydrolysed formula (PHF-W) versus standard cow's milk formula (CMF). We assessed this intervention's cost-effectiveness in Singapore.

    Methods: Modelling techniques were used to simulate, from birth to Month 30, the incidence, and clinical and economic burden of AD in high-risk, non-exclusively breastfed infants fed with PHF-W or CMF for up to four months. Read More

    Basal serum cortisol and adrenocorticotropic hormone levels in patients with atopic dermatitis.
    Dermatol Pract Concept 2017 Oct 31;7(4):25-29. Epub 2017 Oct 31.
    Department of Dermatology, Skin Research Center, Shahid Behehshti University of Medical Sciences, Tehran, Iran.
    Background: Certain studies suggest that percutaneous absorption of topical steroids may cause suppression of hypothalamic-pituitary-adrenal axis (HPAA) in atopic dermatitis (AD) patients. This study aimed to investigate the basal serum cortisol, adrenocorticotropic hormone (ACTH), and IgE levels in patients with AD and their correlation with the disease severity.

    Methods: Levels of basal serum cortisol, ACTH, and IgE were assessed by ELISA in 31 patients with AD and 31 controls. Read More

    Host Responses to Malassezia spp. in the Mammalian Skin.
    Front Immunol 2017 22;8:1614. Epub 2017 Nov 22.
    Section of Immunology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.
    The skin of mammalian organisms is home for a myriad of microbes. Many of these commensals are thought to have beneficial effects on the host by critically contributing to immune homeostasis. Consequently, dysbiosis can have detrimental effects for the host that may manifest with inflammatory diseases at the barrier tissue. Read More

    Expression of TNFα Receptors on Immunocompetent Cells Is Increased in Atopic Dermatitis.
    Int Arch Allergy Immunol 2017 Nov 10. Epub 2017 Nov 10.
    Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology," Novosibirsk, Russia.
    Background: Expression levels of cytokine and growth factor receptors have been found to be important in the regulation of their action. Tumor necrosis factor-α (TNFα) is actively involved in inflammation processes in atopic dermatitis (AD), but the role of TNFα membrane receptors (TNFR) and their regulatory function in AD remains unclear.

    Aim: We aimed to determine the associations of parameters of TNFRα expression on immunocompetent cells with disease severity before and after therapy in AD patients. Read More

    Manuka Honey: A Case Study of Severe Atopic Eczematous Dermatitis Reaction to Henna Tattoo.
    Plast Surg Nurs 2017 Oct/Dec;37(4):154-157
    Jeanine Harrison, MN, BScN, ACNP, RN-EC, NP, is a Medical Aesthetic Nurse Practitioner and a practice expert in PRP techniques for face and hair at TH Medical Aesthetics, Thornhill, Ontario, Canada.
    Many mainstream medications were derived from plants and originally utilized in patient management well prior to the extensive research and testing processes of current pharmaceutical standards. The evolution of therapeutic management within the pharmaceutical and skin care industry often uses synthetic processing of products with less of a focus on the natural ingredients from which they were originally derived. However, more recently there has been a shift in pharmacological management to include the therapeutic use of more holistic medicines and practices and thus a broadening of the uses of nontraditional medical treatment options. Read More

    Methotrexate use in allergic contact dermatitis: a retrospective study.
    Contact Dermatitis 2017 Dec 6. Epub 2017 Dec 6.
    Departments of Dermatology and Pathology, Saint Louis University, St Louis, MO, 63104, USA.
    Background: Methotrexate, a folate antimetabolite, is used to treat atopic dermatitis and psoriasis. Although methotrexate's therapeutic efficacy has been noted in the literature, there are few data on the efficacy of methotrexate treatment for allergic contact dermatitis.

    Objective: To evaluate the efficacy and tolerability of methotrexate in treating allergic contact dermatitis at a single institution, and also to assess methotrexate efficacy in patients with chronic, unavoidable allergen exposure. Read More

    The association between cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis.
    Br J Dermatol 2017 Dec 6. Epub 2017 Dec 6.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Recent studies examining the association between atopic dermatitis (AD) and cardiovascular disease (CVD) and type 2 diabetes have shown inconsistent results. We compared the risk of CVD and diabetes between adult patients with and without AD by searching the Pubmed, Embase, and Web of Science databases. Data extraction was done by two independent reviewers. Read More

    Comparison of atopy patch testing to skin prick testing for diagnosing mite-induced atopic dermatitis: a systematic review and meta-analysis.
    Clin Transl Allergy 2017 29;7:41. Epub 2017 Nov 29.
    Department of Clinical Laboratory, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 at Qingyang Road, Wuxi, 214023 Jiangsu Province People's Republic of China.
    Background: Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. Read More

    Potential inhibitory effects of the traditional herbal prescription Hyangso-san against skin inflammation via inhibition of chemokine production and inactivation of STAT1 in HaCaT keratinocytes.
    Mol Med Rep 2017 Nov 28. Epub 2017 Nov 28.
    Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Yuseong, Daejeon 34054, Republic of Korea.
    Inflammatory skin disease are caused by multiple factors, including susceptibility genes, and immunologic and environmental factors, and are characterized by an increase in epidermal thickness and the infiltration of macrophages, keratinocytes, mast cells, eosinophils and other inflammatory cells. Keratinocytes may serve an important role in the pathogenesis of inflammatory skin diseases. The traditional herbal decoction Hyangso‑san (HSS) has been used to treat symptoms of the common cold, including headache, pantalgia, fever and chills. Read More

    Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models.
    Int J Mol Med 2017 Nov 29. Epub 2017 Nov 29.
    Department of Companion and Laboratory Animal Science, Kongju National University, Yesan 340702, Republic of Korea.
    Flavonols are compounds that have been shown to possess potent anti‑inflammatory effects in cellular and animal models of inflammation. In the present study, the anti‑inflammatory effects and mechanisms of two natural flavonols, quercetin and galangin, in lipopolysaccharide (LPS)‑stimulated RAW264.7 macrophages were investigated. Read More

    Dioscorea quinqueloba Ameliorates Oxazolone- and 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Symptoms in Murine Models.
    Nutrients 2017 Dec 5;9(12). Epub 2017 Dec 5.
    College of Pharmacy, Pusan National University, Busan 46241, Korea.
    Dioscorea quinqueloba has been used for food substances, as well as in herbal medicines for allergic diseases such as asthma. This study aimed to investigate the anti-atopic dermatitis (AD) effects of the total extract of D. quinqueloba rhizomes and active fractionson murine oxazolone- and 2,4-dinitrochlorobenzene-induced models of AD. Read More

    Mechanistic insights on topical tacrolimus for the treatment of atopic dermatitis.
    Pediatr Allergy Immunol 2017 Dec 4. Epub 2017 Dec 4.
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University.
    More than fifteen years have passed since the clinical launch of topical tacrolimus for the treatment of atopic dermatitis. Its efficacy and safety have been clearly demonstrated in many global and domestic short-term and long-term clinical trials. Although the prolonged external application of steroids causes many adverse reactions including cutaneous atrophy, no such reactions occur with the use of topical tacrolimus. Read More

    Magnitude of benefit for topical crisaborole in the treatment of atopic dermatitis in children and adults does not look promising: a critical appraisal.
    Br J Dermatol 2017 Dec 3. Epub 2017 Dec 3.
    Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, U.K.
    Aim: To assess the efficacy and safety of crisaborole ointment, a phosphodiesterase 4 inhibitor, for the treatment of mild or moderate atopic dermatitis (AD) in two phase III studies (AD-301 and AD-302).

    Design And Setting: Two identically designed multicentre, double-blind randomized controlled trials were conducted in the U.S. Read More

    IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration.
    Sci Rep 2017 Dec 4;7(1):16847. Epub 2017 Dec 4.
    Department of Dermatology, Venerology and Allergology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
    Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. Read More

    Developing a written action plan for children with eczema: a qualitative study.
    Br J Gen Pract 2017 Dec 4. Epub 2017 Dec 4.
    Centre for Academic Primary Care, School of Social and Community Medicine, University of Bristol, Bristol.
    Background: Eczema is common in children but adherence to treatments is poor. Written action plans (WAPs) have been shown to help in asthma but the potential value, format, and content of an eczema WAP is unknown.

    Aim: To explore the potential role of an eczema WAP, and to design an eczema-specific WAP. Read More

    TH17 Cell Frequency in Peripheral Blood Is Elevated in Overweight Children without Chronic Inflammatory Diseases.
    Front Immunol 2017 16;8:1543. Epub 2017 Nov 16.
    Children's Hospital, Philipps University, Marburg, Germany.
    Background: The prevalence of obesity has dramatically increased in children in the last few decades and is associated with chronic inflammatory diseases. Fat tissue produces IL-6 and TNF-α, which are stimuli for TH17 cell differentiation. These cells are characterized by expression of the transcription factor receptor-related orphan receptor C (RORC) and by IL-17A production. Read More

    The Microbiota Regulates Immunity and Immunologic Diseases in Dogs and Cats.
    Vet Clin North Am Small Anim Pract 2017 Nov 29. Epub 2017 Nov 29.
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, MS#4467, College Station, TX 77843, USA.
    The complex commensal microbiota found on body surfaces controls immune responses and the development of allergic and inflammatory diseases. New genetic technologies permit investigators to determine the composition of the complex microbial populations found on these surfaces. Changes in the microbiota (dysbiosis) as a result of antibiotic use, diet, or other factors thus influence the development of many diseases in the dog and cat. Read More

    Moderate-to-severe atopic dermatitis patients show increases in serum C-reactive protein levels, correlating with skin disease activity.
    F1000Res 2017 20;6:1712. Epub 2017 Sep 20.
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
    Background: Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is evolving as a systemic disease, and associated systemic inflammation is possibly linked to increases in cardiovascular disease. Methods: We assessed levels of the inflammatory marker CRP in 59 patients with moderate-to-severe AD compared to matched healthy controls, and to determine correlation with skin disease severity. Clinical severity was measured using SCORing of Atopic Dermatitis (SCORAD) and body surface area (BSA). Read More

    Allergic and non-allergic skin reactions associated with growth hormone therapy: elucidation of causative agents.
    J Pediatr Endocrinol Metab 2017 Dec 2. Epub 2017 Dec 2.
    Background: Allergic and non-allergic skin reactions to recombinant human growth hormone (rhGH) are uncommon and infrequently reported. However, physicians should be aware of these potential side effects to determine whether the reactions constitute true allergies and how to proceed with growth hormone therapy. To review allergic and non-allergic skin reactions caused by rhGH and subsequent diagnostic workup and management options. Read More

    A safety review of the medications used to treat atopic dermatitis.
    Expert Opin Drug Saf 2017 Dec 1:1-5. Epub 2017 Dec 1.
    b Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: Atopic dermatitis (AD) is a common disease in children and adults which causes severe physical discomfort and psychosocial distress. Recently novel therapies for AD have been FDA approved for use which creates the need to review the safety surrounding current FDA approved AD medications. Areas covered: Published clinical studies involving topical and oral FDA approved medications for AD are included in this review. Read More

    The IgG response against Staphylococcus aureus is associated with severe atopic dermatitis in children.
    Br J Dermatol 2017 Nov 30. Epub 2017 Nov 30.
    Department of Dermatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.
    Background: An altered immune response against Staphylococcus (S.) aureus might contribute to inflammation and barrier damage in atopic dermatitis (AD).

    Objectives: We profiled IgG antibodies against 55 S. Read More

    [Matricaria chamomilla (aqueous extract) improves atopic dermatitis-like lesions in a murine model].
    Rev Med Inst Mex Seguro Soc 2017 Sep-Oct;55(5):587-593
    Departamento de Ciencias de la Salud, Escuela de Ciencias, Universidad de las Américas Puebla, Puebla, México
    Background: Matricaria Chamomilla L. (Mch), popularly known as chamomile, has been used for centuries as an herbolary remedy due to its broad clinical spectrum. The aim of this study was to evaluate the effect of Mch associated to a vehicle with emollient function in induced atopic dermatitis (AD)-like lesions in a murine model. Read More

    Online education improves pediatric residents' understanding of atopic dermatitis.
    Pediatr Dermatol 2017 Nov 29. Epub 2017 Nov 29.
    Department of Dermatology, School of Medicine, University of Colorado, Aurora, CO, USA.
    Background/objectives: Pediatricians manage skin conditions such as atopic dermatitis (AD) but report that their dermatologic training is inadequate. Online modules may enhance medical education when sufficient didactic or clinical teaching experiences are lacking. We assessed whether an online module about AD improved pediatric residents' knowledge and changed their clinical management of AD. Read More

    Pregnancy and perinatal conditions and atopic disease prevalence in childhood and adulthood.
    Allergy 2017 Nov 29. Epub 2017 Nov 29.
    Paediatric Department, University Hospital Carl Gustav Carus, Dresden, TU, Dresden, Germany.
    Background: Previous studies showed controversial results for the influence of pregnancy-related and perinatal factors on subsequent respiratory and atopic diseases in children. The aim of this study was to assess the association between perinatal variables and the prevalence of asthma, bronchial hyperreactivity, flexural eczema, allergic rhinitis, and sensitization in childhood and early adulthood.

    Methods: The studied population was first examined in Munich and Dresden in 1995/1996 at age 9-11 yrs. Read More

    Dupilumab with concomitant topical corticosteroids in adult patients with atopic dermatitis who are not adequately controlled with or are intolerant to ciclosporin A, or when this treatment is medically inadvisable: a placebo-controlled, randomized phase 3 clinical trial (LIBERTY AD CAFÉ).
    Br J Dermatol 2017 Nov 28. Epub 2017 Nov 28.
    Regeneron Pharmaceuticals, Inc, Tarrytown, NY, U.S.A.
    Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that may require systemic therapy. Ciclosporin A (CsA) is a widely-used, potent immunosuppressant for AD. CsA is not effective in all patients, and side effects limit its use. Read More

    Anti-allergic effects of novel sulfated polysaccharide sacran on mouse model of 2,4-Dinitro-1-fluorobenzene-induced atopic dermatitis.
    Int J Biol Macromol 2017 Nov 27;108:112-118. Epub 2017 Nov 27.
    Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan; Program for Leading Graduate Schools "Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program", Kumamoto University, Japan. Electronic address:
    In this study, in order to investigate the potential of the novel polysaccharide sacran from Aphanothece Sacrum for development of atopic dermatitis (AD), we evaluated the potential of pretreatment with topical sacran to prevent the development of hapten (dinitrofluorobenzene: DNFB)-induced AD-like disease in mice. In the AD model mice, sacran markedly ameliorated AD symptoms such as scratching behavior and edema in ear. In addition, sacran significantly increased water content of the stratum corneum which regulates the skin barrier function. Read More

    Diagnosis and Management of Conjunctivitis for the Dermatologist.
    J Cutan Med Surg 2017 Nov 1:1203475417743233. Epub 2017 Nov 1.
    3 Probity Medical Research, Waterloo, ON, Canada.
    Atopic dermatitis is a chronic, sometimes relapsing inflammatory skin condition that presents with pruritus and characteristic skin manifestations. Conjunctivitis is a common ocular comorbidity affecting almost half of patients with the risk increasing with atopic dermatitis severity. Recent targeted biologic therapies that successfully treat atopic skin disease, including dupilumab, which blocks interleukin (IL)-4 and IL-13, as well as agents that block IL-13 alone, have been associated with an increased rate of conjunctivitis in clinical trials. Read More

    Challenging Treatment of Ocular Surface Squamous Neoplasia in Patients with Atopic Disease.
    Ocul Immunol Inflamm 2017 Nov 30:1-6. Epub 2017 Nov 30.
    a Bascom Palmer Eye Institute, Department of Ophthalmology , University of Miami , Miami , Florida , USA.
    Purpose: Few studies have described ocular surface squamous neoplasia (OSSN) and its association with atopic diseases and there is no consensus on the course of OSSN in atopic patients. We thereby report three patients with atopy and OSSN.

    Methods: Retrospective case series. Read More

    Complementary, alternative and integrative medicine for childhood atopic dermatitis.
    Recent Pat Inflamm Allergy Drug Discov 2017 Nov 28. Epub 2017 Nov 28.
    School of Pharmacy, The Chinese University of Hong Kong. Hong Kong.
    Backgroud: Atopic dermatitis (AD) is a chronic relapsing dermatosis associated with itch, sleep disturbance and poor quality of life. Treatment of AD includes the use of emollients, and topical and systemic immunomodulating agents. Many patients also use complementary and alternative medicine (CAM). Read More

    Systematic Review and Meta-Analysis of Human Skin Diseases Due to Particulate Matter.
    Int J Environ Res Public Health 2017 Nov 25;14(12). Epub 2017 Nov 25.
    Department of BioNano Technology, Gachon University, 1342 Seongnam, Korea.
    This study investigated the effects of particulate matter (PM) on human skin diseases by conducting a systematic review of existing literature and performing a meta-analysis. It considered articles reporting an original effect of PM on human skin. From among 918 articles identified, 13 articles were included for further consideration after manual screening of the articles resulted in the exclusion of articles that did not contain data, review articles, editorials, and also articles in languages other than English. Read More

    Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant.
    An Bras Dermatol 2017 May-Jun;92(3):383-385
    Dermatology Service of the General Polyclinic of Rio de Janeiro (PGRJ) - Rio de Janeiro (RJ), Brazil.
    Crusted or Norwegian scabies is a parasitic infectious disease caused by Sarcoptes scabiei var. hominis that mainly affects immunocompromised individuals and those with neurological patients. We report a case of crusted scabies in a 4-month-old infant who had been treated erroneously for atopic dermatitis with high doses of corticosteroids. Read More

    Infectious Complications following Breast Reconstruction Using Tissue Expanders in Patients with Atopic Dermatitis.
    Plast Reconstr Surg Glob Open 2017 Oct 20;5(10):e1535. Epub 2017 Oct 20.
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
    Infectious complications represent one of the most prominent factors contributing to tissue expander (TE) loss in breast reconstruction procedures. Several patient characteristics that increase the risk for surgical-site infection or TE infection have been reported, but no study has focused on the relationship between atopic dermatitis (AD) and TE infection or surgical-site infection. Recently, we investigated 203 cases of breast reconstruction surgeries performed using TEs and noted that all 3 patients who had AD developed infectious complications that ultimately led to TE removal. Read More

    Adverse events of Dupilumab in adults with moderate-to-severe atopic dermatitis: A meta-analysis.
    Int Immunopharmacol 2017 Nov 25;54:303-310. Epub 2017 Nov 25.
    Department of Allergy, Chongqing General Hospital, 2nd Floor, Gangtian Building, Zhongshansan Road, Yuzhong District, Chongqing, China. Electronic address:
    Background: Dupilumab, a fully human monoclonal antibody against interleukin-4 receptor alpha, inhibits the signals of interleukin-4 and interleukin-13, and has also shown significant efficacy in patients with moderate-to-severe atopic dermatitis (AD), while the effect of it on adverse events remains controversial.

    Objective: To assess the influence of dupilumab on adverse events in adults with moderate-to-severe AD.

    Method: Randomised controlled trials (RCTs) that compared dupilumab with a placebo for patients with moderate-to-severe AD were searched in the MEDLINE, EMBASE, Web of Science and Cochrane databases. Read More

    Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis.
    Acta Derm Venereol 2017 Nov 28. Epub 2017 Nov 28.
    Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, SE-17176 Stockholm, Sweden.
    Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus, stress and anxiety. Aprepitant is a NK-1 receptor antagonist. Read More

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