25,692 results match your criteria Dermatitis Atopic


Systemic Therapies for Moderate-to-Severe Atopic Dermatitis: Expert Perspectives in Practice

J Drugs Dermatol 2019 Feb;18(2):122-129

Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects around 13% of children and 7% of adults in the US. It can have a significant impact on the quality of life (QoL) of affected individuals due to pruritus and the visibility of lesions on the skin. AD is increasingly recognized as a systemic disease, since dysregulation of the adaptive and innate immune systems plays a key role in the underlying disease pathogenesis, which has important implications for how the condition is treated. Read More

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February 2019

Multimorbidities of Pediatric Allergic Rhinitis.

Curr Allergy Asthma Rep 2019 Feb 22;19(2):13. Epub 2019 Feb 22.

INGENIO, Immunoal.lèrgia Respiratòria Clínica i Experimental (IRCE), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

Purpose Of Review: Most children and adolescents with allergic rhinitis (AR) present extra-nasal multimorbid conditions, including conjunctivitis, asthma, atopic dermatitis, rhinosinusitis, or seromucous otitis. Additionally, they may present nasal obstructive disorders, such as septal deformity, turbinate enlargement, and adenoidal hyperplasia, which worsen nasal symptoms, especially nasal obstruction. This is a narrative review on the current state of the concomitant presence of AR and one or more multimorbidities. Read More

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http://dx.doi.org/10.1007/s11882-019-0843-9DOI Listing
February 2019

Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort.

Clin Transl Allergy 2019 11;9. Epub 2019 Feb 11.

1Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.

Background: Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.

Material And Method: A cross-sectional multicentre study enrolled children aged 6-7 and 13-14 years and adults aged 20-44 years from a Polish national cohort. Read More

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http://dx.doi.org/10.1186/s13601-019-0246-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369558PMC
February 2019

Current Strategies to Inhibit High Affinity FcεRI-Mediated Signaling for the Treatment of Allergic Disease.

Authors:
Gregorio Gomez

Front Immunol 2019 7;10:175. Epub 2019 Feb 7.

Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.

Allergies and asthma are a major cause of chronic disease whose prevalence has been on the rise. Allergic disease including seasonal rhinitis, atopic dermatitis, urticaria, anaphylaxis, and asthma, are associated with activation of tissue-resident mast cells and circulating basophils. Although these cells can be activated in different ways, allergic reactions are normally associated with the crosslinking of the high affinity Fc receptor for Immunoglobulin E, FcεRI, with multivalent antigen. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374298PMC
February 2019

Herpes Virus Reactivation in Astronauts During Spaceflight and Its Application on Earth.

Front Microbiol 2019 7;10:16. Epub 2019 Feb 7.

Jes Tech, KBR Wyle Laboratories Houston, Houston, TX, United States.

Latent herpes virus reactivation has been demonstrated in astronauts during shuttle (10-16 days) and International Space Station (≥180 days) flights. Following reactivation, viruses are shed in the body fluids of astronauts. Typically, shedding of viral DNA is asymptomatic in astronauts regardless of mission duration; however, in some cases, live/infectious virus was recovered by tissue culture that was associated with atopic-dermatitis or skin lesions during and after spaceflight. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374706PMC
February 2019

Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses.

Cell Mol Immunol 2019 Feb 21. Epub 2019 Feb 21.

Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

The type 2 immune response is critical for host defense against large parasites such as helminths. On the other hand, dysregulation of the type 2 immune response may cause immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis. Thus, a balanced type 2 immune response must be achieved to mount effective protection against invading pathogens while avoiding immunopathology. Read More

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http://dx.doi.org/10.1038/s41423-019-0210-8DOI Listing
February 2019

Dupilumab provides important clinical benefits to patients with atopic dermatitis who do not achieve clear or almost clear skin according to the Investigator's Global Assessment: a pooled analysis of data from 2 phase III trials.

Br J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, U.S.A.

Background: In the US, an Investigator's Global Assessment (IGA) score of ≤ 1 (clear/almost clear skin) has been the regulatory outcome standard measure for registration clinical trials in atopic dermatitis (AD), including those supporting the recent approval of dupilumab.

Objective: To evaluate the treatment effect of dupilumab in patients with IGA>1 at the end of treatment, using other validated outcome measures for AD signs, symptoms and quality of life.

Methods: LIBERTY AD SOLO 1 and 2 were two 16-week, randomized, double-blind trials enrolling adult patients with moderate-to-severe AD (IGA≥3) inadequately controlled with topical treatment. Read More

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http://dx.doi.org/10.1111/bjd.17791DOI Listing
February 2019

Limitations of generalizability and reproducibility of systematic reviews in dermatology.

J Am Acad Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, IL. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.01.090DOI Listing
February 2019

Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model.

Sci Rep 2019 Feb 20;9(1):2364. Epub 2019 Feb 20.

Department of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina, Kyoto, 607-8414, Japan.

Allopregnanolone (ALLO) is a neurosteroid produced in the brain, but so far, no study has explored its link with itching. Herein, we used a diet-induced atopic dermatitis mouse model to examine whether exogenously administered and endogenously produced ALLO contribute to inducing scratching. Systemic administration of ALLO elicited robust scratching in the atopic dermatitis model, while it did not affect spontaneous and pruritogen-induced scratching in normal mice. Read More

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http://dx.doi.org/10.1038/s41598-019-38858-3DOI Listing
February 2019

Authors:

Arerugi 2019 ;68(1):56-57

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http://dx.doi.org/10.15036/arerugi.68.56DOI Listing
January 2019

The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype.

Sci Transl Med 2019 Feb;11(480)

National Jewish Health, Denver, CO 80206, USA.

Skin barrier dysfunction has been reported in both atopic dermatitis (AD) and food allergy (FA). However, only one-third of patients with AD have FA. The purpose of this study was to use a minimally invasive skin tape strip sampling method and a multiomics approach to determine whether children with AD and FA (AD +) have stratum corneum (SC) abnormalities that distinguish them from AD without FA (AD -) and nonatopic (NA) controls. Read More

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http://dx.doi.org/10.1126/scitranslmed.aav2685DOI Listing
February 2019

Sodium chloride is an ionic checkpoint for human T2 cells and shapes the atopic skin microenvironment.

Sci Transl Med 2019 Feb;11(480)

Institute of Virology, Technical University of Munich, 81675 Munich, Germany.

The incidence of allergic diseases has increased over the past 50 years, likely due to environmental factors. However, the nature of these factors and the mode of action by which they induce the type 2 immune deviation characteristic of atopic diseases remain unclear. It has previously been reported that dietary sodium chloride promotes the polarization of T helper 17 (T17) cells with implications for autoimmune diseases such as multiple sclerosis. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau0683DOI Listing
February 2019

A review of dupilumab in the treatment of atopic diseases.

Hum Vaccin Immunother 2019 Feb 20. Epub 2019 Feb 20.

a Department of Dermatology , University of California, San Francisco , San Francisco.

Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important drivers of atopic diseases. In March of 2017, the United States Food and Drug Administration (FDA) approved dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults that is uncontrolled with topical medications, becoming the first biologic agent approved to treat this chronic skin condition. In October of 2018, Dupilumab received approval by the FDA as an add-on maintenance therapy in patients with moderate-to-severe asthma aged 12 years or older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma. Read More

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http://dx.doi.org/10.1080/21645515.2019.1582403DOI Listing
February 2019

Prevalence of Severe Atopic Dermatitis in Adults and Children in a Health Area of Madrid, Spain.

J Investig Allergol Clin Immunol 2019 Feb;29(1):77-79

Allergy Department, University Hospital Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0339DOI Listing
February 2019

Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin.

Skin Pharmacol Physiol 2019 Feb 15;32(2):94-100. Epub 2019 Feb 15.

Department of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Halle (Saale),

Background/aims: Free amino acids (FAAs) and urea, present inside the corneocytes, can be important indicators of skin condition. However, due to the lack of a standard extraction protocol for FAAs from corneocytes, conflicting research results have been reported. Therefore, the purpose of this study was (1) to standardize the extraction protocol and (2) to investigate FAA profiles in healthy young and healthy old volunteers, as well as in psoriasis and atopic dermatitis patients. Read More

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https://www.karger.com/Article/FullText/495992
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http://dx.doi.org/10.1159/000495992DOI Listing
February 2019
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Factors affecting self-reported chemical intolerance: A five-year follow-up study in Japan.

J Psychosom Res 2019 Mar 5;118:1-8. Epub 2019 Jan 5.

Department of Environmental Health, National Institute of Public Health, Wako 351-0197, Japan. Electronic address:

Objective: Chemical intolerance (CI) has become a strong public health concern in industrialized countries. The Japanese Chemical Intolerance (JCI) study was conducted in January 2012 with a cohort of 7245 adults from population-based sampling as the baseline. The aim of the present study was to investigate the factors involved in the improvement and development of CI from the five-year follow-up study. Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.01.001DOI Listing

Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects.

Clin Pharmacol Ther 2019 Feb 19. Epub 2019 Feb 19.

BioMarin Pharmaceutical Inc, Novato, California, USA.

Tezepelumab (AMG 157) is a monoclonal antibody that targets thymic stromal lymphopoietin (TSLP) and has shown benefits in treating asthma. We assessed the safety, tolerability, and pharmacokinetics of single- and multiple-ascending doses in two randomized, double-blind, placebo-controlled Phase 1 studies. Healthy and atopic dermatitis subjects were enrolled in the single-dose study, and healthy subjects in the multiple-dose study. Read More

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http://dx.doi.org/10.1002/cpt.1401DOI Listing
February 2019

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case-control study.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Background: Atopic dermatitis (AD) is associated with many autoimmune diseases, in part due to overlapping genetic risk loci. While parental atopic disease is an important risk for AD in the offspring, little is known on the putative associations between parental autoimmune disease and AD in their children.

Materials And Methods: All children born between 1996 and 2011 who received a diagnosis of AD in the hospital system before their fifth birthday were matched 1 : 10 with children from the general population. Read More

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http://dx.doi.org/10.1111/jdv.15413DOI Listing
February 2019

Epithelial barrier repair and prevention of allergy.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and.

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD. Read More

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http://dx.doi.org/10.1172/JCI124608DOI Listing
February 2019

Novel systemic therapies in atopic dermatitis: what do we need to fulfil the promise of a treatment revolution?

F1000Res 2019 31;8. Epub 2019 Jan 31.

Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK.

Patients with atopic dermatitis (AD) who do not adequately respond to topical therapy and phototherapy often need systemic immunomodulatory treatment to control their symptoms. Conventional systemic agents, such as ciclosporin, azathioprine, and methotrexate, have been used for decades, but there are concerns about their safety profile. There are now many novel systemic agents emerging through clinical trials, which may have great potential in the treatment of AD. Read More

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http://dx.doi.org/10.12688/f1000research.17039.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357995PMC
January 2019

Real-world characteristics and disease burden of patients with asthma prior to treatment initiation with mepolizumab or omalizumab: a retrospective cohort database study.

J Asthma Allergy 2019 25;12:43-58. Epub 2019 Jan 25.

Respiratory, US Medical Affairs, GSK, La Jolla, CA, USA.

Purpose: Patients with severe asthma are eligible for asthma-specific biologics as add-on therapies, such as mepolizumab and omalizumab, when optimized controller therapies are unable to control their symptoms. However, few real-world data are available to describe the characteristics and associated economic burden of patients considered to be candidates for mepolizumab or omalizumab therapy.

Methods: This retrospective cohort study investigated patients with asthma (≥12 years of age) identified at the time of first mepolizumab or omalizumab administration (index date) in the MarketScan Commercial Database. Read More

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https://www.dovepress.com/real-world-characteristics-and-dis
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http://dx.doi.org/10.2147/JAA.S189676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354698PMC
January 2019
3 Reads

[Are there indications of "sensory processing sensitivity" (SPS) in atopically predisposed persons? - An examination of parents of children with atopic dermatitis in inpatient treatment].

Z Psychosom Med Psychother 2019 Feb;65(1):14-26

Klinik für Dermatologie und Allergologie Psychosomatische Dermatologie Justus-Liebig-Universität Gießen Deutschland Psychosomatische Dermatologie, Justus-Liebig-Universität Gießen.

Are there indications of "sensory processing sensitivity" (SPS) in atopically predisposed persons? - An examination of parents of children with atopic dermatitis in inpatient treatment Objectives: Clinically, the parents of children with atopic dermatitis often give the impression of increased sensitivity. It was examined, whether the parents show characteristics of "sensory processing sensitivity" (SPS) such as extraordinary perception and processing, hypersensitivity to external stimuli, increased excitability and excessive demands.

Methods: 64 parents of children with atopic dermatitis were therefore examined with the Highly Sensitive Person Scale (Aron 1996) and three proven questionnaires. Read More

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http://dx.doi.org/10.13109/zptm.2019.65.1.14DOI Listing
February 2019

Tachykinin upregulation in atopic dermatitis.

Immunopharmacol Immunotoxicol 2019 Feb 18:1-6. Epub 2019 Feb 18.

a Department of Medicine Solna, Dermatology and Venereology Unit , Karolinska Institutet , Stockholm , Sweden.

Context: Atopic dermatitis (AD) is a chronic, inflammatory, itching skin disorder, which may worsen due to stress, depression and anxiety. Tachykinins may be involved in inflammation signaling as well as they may have a role in stress, depression and anxiety.

Objective: This study aimed to measure the expression of tachykinin markers, in the skin of patients with AD, and the correlation of these tachykinins with clinical and psychodemographic parameters. Read More

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http://dx.doi.org/10.1080/08923973.2018.1558235DOI Listing
February 2019

The environment and its effect on allergic sensitization and atopic dermatitis, and colostrum and the immune system of the preterm infant.

Pediatr Allergy Immunol 2019 Mar;30(2):147-148

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1111/pai.13029DOI Listing

Stratum corneum interleukin-33 expressions correlate with the degree of lichenification and pruritus in atopic dermatitis lesions.

Clin Immunol 2019 Feb 14;201:1-3. Epub 2019 Feb 14.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

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http://dx.doi.org/10.1016/j.clim.2019.02.006DOI Listing
February 2019

African American Ancestry Contribution to Asthma and Atopic Dermatitis.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

University of Colorado Denver, Aurora CO. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10811206193010
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http://dx.doi.org/10.1016/j.anai.2019.02.009DOI Listing
February 2019
2 Reads

Silver nanoparticles assessment in moisturizing creams by ultrasound assisted extraction followed by sp-ICP-MS.

Talanta 2019 May 24;197:530-538. Epub 2019 Jan 24.

Trace Element, Spectroscopy and Speciation Group (GETEE), Strategic Grouping in Materials (AEMAT), Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Chemistry, Universidade de Santiago de Compostela, Avenida das Ciencias, s/n., 15782 Santiago de Compostela, Spain. Electronic address:

Advances on nanometrology require reliable sample pre-treatment methods for extracting/isolating nanomaterials from complex samples. The current development deals with a discontinuous ultrasonication (60% amplitude, 15 cycles of ultrasound treatment for 59 s plus relaxing stage for 59 s, 20 mL of methanol) method for a fast and quantitative extraction of silver nanoparticles (Ag NPs) from moisturizing creams. Possibilities offered by modern inductively coupled plasma mass spectrometry (ICP-MS) which allow 'single particle' assessment (sp-ICP-MS) have been used for Ag NPs assessment (Ag NPs concentration and Ag size distribution). Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.068DOI Listing
May 2019
1 Read

Adverse Events from Emollient Use in Eczema: A Restricted Review of Published Data.

Dermatol Ther (Heidelb) 2019 Feb 15. Epub 2019 Feb 15.

Population Health Sciences, University of Bristol, Bristol, UK.

Atopic dermatitis/eczema is a chronic inflammatory skin condition, and emollients are the first-line treatment. Despite their widespread use, there is uncertainty about the frequency and type of adverse events associated with different emollients. We conducted a restricted review of published data on adverse events associated with emollient use in eczema. Read More

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http://dx.doi.org/10.1007/s13555-019-0284-3DOI Listing
February 2019

A Summary of 2018 and What Lies Ahead for Dermatology and Therapy in 2019.

Dermatol Ther (Heidelb) 2019 Mar 15;9(1):1-3. Epub 2019 Feb 15.

Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR BRC, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/s13555-019-0283-4DOI Listing
March 2019
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Alkali-soluble pectin suppresses IgE production in human myeloma cell line in vitro.

Cytotechnology 2019 Feb 15. Epub 2019 Feb 15.

Department of Creative Engineering, National Institute of Technology, Kitakyushu College, 5-20-1 Shii, Kokuraminami-ku, Kitakyushu, Fukuoka, 802-0985, Japan.

We found that strawberry (Fragaria x ananassa) extract has an IgE production suppressive activity and its oral administration improved skin manifestation in atopic dermatitis model mice. In present study, we identified an active substance using the IgE-producing human myeloma cell line U266. Gel filtration experiment indicated that the IgE suppressor was more than 6 kDa in molecular size. Read More

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http://dx.doi.org/10.1007/s10616-019-00306-5DOI Listing
February 2019

Determinants of disease severity among patients with atopic dermatitis: association with components of the atopic march.

Arch Dermatol Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermato-venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

We aimed to explore the association of key clinical characteristics with disease severity in atopic dermatitis (AD) and its relation to components of the atopic march in a large hospital cohort. Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, between January 2012 and December 2017, were compared based on disease severity (SCORAD); mild (< 25), moderate (25-50) and severe (> 50). A total of 470 AD patients were included: 122 small children (< 4 years of age), 103 children/adolescents (age 4-15 years) and 245 adults (> 15 years of age). Read More

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http://dx.doi.org/10.1007/s00403-019-01895-zDOI Listing
February 2019
1 Read

High dietary fat intake induces a microbiota signature that promotes food allergy.

J Allergy Clin Immunol 2019 Feb 12. Epub 2019 Feb 12.

Institute of Pathology, Department of Experimental Pathology, University of Bern, Bern, Switzerland. Electronic address:

Background: Diet-induced obesity and food allergies rise in tandem, but a potential cause-and-effect relationship between these diseases of affluence remains to be tested.

Objective: To test the role of high dietary fat intake, diet-induced obesity and associated changes in gut microbial community structure on food allergy pathogenesis.

Methods: Mice were fed a high fat diet (HFD) for 12 weeks prior to food allergen sensitization on an atopic dermatitis-like skin lesion followed by intra-gastric allergen challenge to induce experimental food allergy. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.043DOI Listing
February 2019
1 Read

Towards personalized treatment in atopic dermatitis.

Expert Opin Biol Ther 2019 Feb 15. Epub 2019 Feb 15.

a National Expertise Center for Atopic Dermatitis. Department of Dermatology and Allergology , University Medical Center Utrecht , The Netherlands .

Introduction: For many years, oral immunosuppressive drugs such as cyclosporine A, azathioprine, mycophenolic acid and methotrexate were the only treatment options, in addition to topical treatment, in patients with severe atopic dermatitis (AD). Dupilumab, a monoclonal antibody targeting the IL-4 receptor alpha, is the first antibody-based treatment commercially available for the treatment of AD. In the near future, more antibody-based treatments and small molecules will become available in the treatment of severe AD. Read More

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http://dx.doi.org/10.1080/14712598.2019.1583204DOI Listing
February 2019

Food Protein-Induced Enterocolitis Syndrome in South Tyrol 2012-2016: a population based study.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

College of Health-Care Professions Claudiana, Bolzano/Bozen.

Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE-mediated food allergy to protein mainly in cow milk (CM) that typically presents in early infancy. Projectile and repetitive vomiting are the main clinical symptoms after 1-4 hours of trigger food ingestion. Rapid recognition and installment of a specific diet are important to avoid serious complications in affected children (see figure 1). Read More

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http://doi.wiley.com/10.1111/jdv.15510
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http://dx.doi.org/10.1111/jdv.15510DOI Listing
February 2019
1 Read

Validation of the dermatology-specific proxy instrument the Infants and Toddlers Dermatology Quality of Life.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatrics number 1, National Medical University, Kiev, Ukraine.

Background: The first dermatology-specific proxy health related quality of life (HRQoL) instrument for children 0-4 years old with skin diseases, the Infants and Toddlers Dermatology Quality of Life (InToDermQoL), was recently developed. In order to avoid the problem of cross-cultural inequivalence focus groups work and pilot tests were organized simultaneously in all national centres of the project. The InToDermQoL showed good comprehensibility, clarity and acceptance. Read More

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http://dx.doi.org/10.1111/jdv.15496DOI Listing
February 2019

The Role of Probiotics in Preventing Allergic Disease.

Children (Basel) 2019 Feb 5;6(2). Epub 2019 Feb 5.

Department of Pediatrics, Section of Immunology, Allergy, Rheumatology, and Retrovirology, Texas Children's Hospital, Houston, TX 77030, USA.

The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. Read More

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http://dx.doi.org/10.3390/children6020024DOI Listing
February 2019
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Hand eczema among Dutch beekeepers - a cross-sectional study.

J Dtsch Dermatol Ges 2019 02;17(2):158-166

University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.

Background And Objectives: Studies of beekeepers have mostly focused on contact allergy to propolis. The overall prevalence of hand eczema (HE) in beekeepers has not been studied. Our objectives were to gain insight into the prevalence of HE in the Dutch beekeeper population; to define the impact of beekeeping activities on HE and vice versa; and to determine associated factors. Read More

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http://dx.doi.org/10.1111/ddg.13754DOI Listing
February 2019
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Rituximab revisited: successful management of severe childhood atopic dermatitis.

Eur J Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology, Hospital de Santo António dos Capuchos.

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http://dx.doi.org/10.1684/ejd.2018.3476DOI Listing
February 2019

Systematic Analysis of Selective Bactericidal Activity of Fatty Acids against Staphylococcus aureus with Minimum Inhibitory Concentration and Minimum Bactericidal Concentration.

J Oleo Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University.

Bacterial flora on the skin surface contains Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) which causes rough skin and atopic dermatitis and enhances innate immunity, respectively. Read More

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http://dx.doi.org/10.5650/jos.ess18220DOI Listing
February 2019

Development of a gold nanoparticle-labeled sandwich format lateral flow immunoassay kit for the detection of tropical house dust mite Suidasia pontifica.

Protein Pept Lett 2019 Feb 12. Epub 2019 Feb 12.

The Graduate School, bCollege of Science, University of Santo Tomas, España Boulevard, Sampaloc 1015, Manila. Philippines.

The house dust mite Suidasia pontifica (Sp) is an important source of allergens in tropical regions that trigger IgE-mediated allergic reactions such as allergic asthma, atopic dermatitis and allergic rhinitis. Detection of Sp-specific proteins are important in the management and prevention of allergic diseases. The study aimed to provide a proof of concept for a gold nanoparticle-labeled sandwich format lateral flow immunoassay (LFIA) kit for the detection of Sp-specific proteins. Read More

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http://dx.doi.org/10.2174/0929866526666190212164751DOI Listing
February 2019
2 Reads
1.068 Impact Factor

Feasibility Analysis of Interleukin-13 as a Target for a Therapeutic Vaccine.

Vaccines (Basel) 2019 Feb 12;7(1). Epub 2019 Feb 12.

University of Dundee, Medical School, Department of Molecular and Clinical Medicine, Jacqui Woods Centre, Ninewells Hospital, Ninewells Drive, Dundee DD1 9SY, UK.

Background: The development of therapeutic vaccines requires thorough knowledge of potential hazards associated with long-term inactivation of self-proteins. Among potential targets, interleukin 13 (IL-13) merits consideration, as monoclonal antibodies disrupting IL-13 signaling are proving to be exceedingly effective in common conditions such as atopic dermatitis.

Objective: Given the mass publication of scientific data, an appraisal of safety aspects is challenging. Read More

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http://dx.doi.org/10.3390/vaccines7010020DOI Listing
February 2019

Use of Complementary and Alternative Therapies in Outpatients with Atopic Dermatitis from a Dermatological University Department.

Dermatology 2019 Feb 13:1-7. Epub 2019 Feb 13.

Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Treatment of atopic dermatitis (AD) may be challenging, therefore some patients seek complementary and alternative medications (CAM). We determined prevalence and predictors for CAM use in a hospital cohort of AD patients.

Material And Methods: Between January 1, 2012, and December 31, 2017, AD patients referred to the dermatological outpatient clinic at Bispebjerg Hospital were included in the study. Read More

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https://www.karger.com/Article/FullText/496274
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http://dx.doi.org/10.1159/000496274DOI Listing
February 2019
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Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide.

Br J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Regeneron Pharmaceuticals, Inc, Tarrytown, NY, U.S.A.

Background: Atopic dermatitis (AD) is a heterogeneous disease with a multifactorial aetiology and complex pathophysiology. This heterogeneity translates into different trajectories of disease progression with respect to severity, persistence, and risk of development of atopic comorbidities. Determining which possible disease trajectories or comorbidities any individual child might develop is challenging in clinical practice. Read More

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http://dx.doi.org/10.1111/bjd.17766DOI Listing
February 2019

Prevalence of vitamin D deficiency and its relationship with factors associated with recurrent wheezing.

J Bras Pneumol 2019 Feb 11;45(1):e20170431. Epub 2019 Feb 11.

. Departamento de Medicina e Enfermagem, Universidade Federal de Viçosa, Viçosa (MG) Brasil.

Objective: To determine the prevalence of vitamin D deficiency/insufficiency in children 0-18 years of age with recurrent wheezing and/or asthma residing in the microregion of Viçosa, Minas Gerais, Brazil, and treated at a referral center, and to determine its association with major risk factors for wheezing.

Methods: A cross-sectional study was performed using a semi-structured questionnaire, which was administered by trained interviewers to the legal guardians of the study participants. Data were obtained regarding general characteristics of recurrent wheezing; general sociodemographic, environmental, and biologic factors; and atopy-related factors. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-3713/e20170431DOI Listing
February 2019
4 Reads

Pediatric warts: update on interventions.

Cutis 2019 Jan;103(1):26;27;28;29;30;E2;E3;E4

Departments of Dermatology and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Warts are superficial viral infections of the skin that are extremely common in children. The infection usually lasts more than 1 year and can be moderately contagious in specific settings; for instance, warts are particularly common and spread more easily in the setting of atopic dermatitis, a chronic, itchy pediatric skin condition caused by barrier and immune defects. Therapies for pediatric warts are characterized according to 6 major categories: destructive; immune stimulating; immune modulating, including normalization of epithelial growth; vascular destructive; irritant; and nitric oxide releasing. Read More

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January 2019

Pityriasis amiantacea following bone marrow transplant.

Cutis 2019 Jan;103(1):46-50

San Diego Family Dermatology, National City, California; Family Health Center of San Diego, California; Scripps Mercy Hospital Chula Vista, California; and the College of Osteopathic Medicine, Touro University California, Vallejo, USA.

Pityriasis amiantacea (PA) is a hair disorder characterized by matting of multiple hair shafts, typically occurring as an idiopathic condition. A 67-year-old woman with multiple myeloma who developed PA following a bone marrow transplant with melphalan conditioning is described.She noted initial changes in scalp hair regrowth 4 weeks posttransplant. Read More

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January 2019
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Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (ADDRESS-J): Baseline characteristics, treatment history and disease burden.

J Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Sanofi K.K., Tokyo, Japan.

Moderate to severe atopic dermatitis (AD) has a high disease burden and a significant effect on quality of life. Observational studies are necessary to determine the patient disease burden and long-term disease control in the Japanese population. ADDRESS-J is a non-interventional, observational registry of adult Japanese patients with moderate to severe AD. Read More

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http://dx.doi.org/10.1111/1346-8138.14787DOI Listing
February 2019

Acute Exacerbation of Fever Following Administration of Tropicamide and Phenylephrine Ophthalmic Solution: A Case Report.

Drug Saf Case Rep 2019 Feb 12;6(1). Epub 2019 Feb 12.

Juntendo University School of Medicine, Tokyo, Japan.

A 24-year-old woman with atopic dermatitis and persistent fever (axillary temperature of 37-38 °C for 6 months) received combination ophthalmic drops containing tropicamide and phenylephrine (Mydrin-P), which exacerbated her fever within 15 min after instillation. Her axillary fever reached 40.1 °C but resolved the following day. Read More

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http://dx.doi.org/10.1007/s40800-019-0096-5DOI Listing
February 2019

Anti‑inflammatory effects of Dendropanax morbifera in lipopolysaccharide‑stimulated RAW264.7 macrophages and in an animal model of atopic dermatitis.

Mol Med Rep 2019 Mar 22;19(3):2087-2096. Epub 2019 Jan 22.

Department of Companion and Laboratory Animal Science, Kongju National University, Yesan, Chungcheongnam 32439, Republic of Korea.

Dendropanax morbifera (D. morbifera), known as Dendro, means 'omnipotent drug' (Panax), and has been called the panacea tree. Various studies on D. Read More

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http://dx.doi.org/10.3892/mmr.2019.9887DOI Listing

Contact allergy in children with atopic dermatitis: a retrospective study.

Endocr Metab Immune Disord Drug Targets 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, IT-70124 Bari. Italy.

Backgound: The relationship between atopic dermatitis and allergic contact dermatitis is frequently debated, particularly in children. The impaired skin barrier of atopic subjects can facilitate the penetration of exogenous agents and its mutations in filaggrin gene might be implicated in an increased risk to develop contact dermatitis. Moreover, atopic children are protractedly exposed to chemical substances contained in skincare products from an early age. Read More

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http://www.eurekaselect.com/169857/article
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http://dx.doi.org/10.2174/1871530319666190211123342DOI Listing
February 2019
4 Reads