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    Mycophenolate mofetil therapy in adult patients with recalcitrant atopic dermatitis.
    J Dermatolog Treat 2018 Apr 23:1-10. Epub 2018 Apr 23.
    a Department of Dermatology , Rambam Health Care Campus, Technion , Haifa , Israel.
    Patients with severe atopic dermatitis (AD) may require potent immunosuppressive therapy to control their disease. Mycophenolate mofetil (MMF) has been suggested as a safe and effective drug in these cases. We have used oral MMF 2-3gr/day in adult patients with severe recalcitrant AD who failed other major systemic drugs, or where other drugs, including cyclosporine, methotrexate and azathioprine, were contraindicated. Read More

    Measured moisture in buildings and adverse health effects: a review.
    Indoor Air 2018 Apr 23. Epub 2018 Apr 23.
    Indoor Air Quality Section, California Department of Public Health, 850 Marina Bay Parkway, G365, Richmond, CA, 94804.
    It has not yet been possible to quantify dose-related health risks attributable to indoor dampness or mold (D/M), to support the setting of health-related limits for D/M. An overlooked target for assessing D/M is moisture in building materials, the critical factor allowing microbial growth. A search for studies of quantified building moisture and occupant health effects identified three eligible studies. Read More

    Serum zonulin is associated with presence and severity of atopic dermatitis in children, independent of total IgE and eosinophil.
    Clin Exp Allergy 2018 Apr 22. Epub 2018 Apr 22.
    Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam.
    Atopic dermatitis (AD) is characterized by dry eczematous skin lesions with intense pruritus due to a hyperactive immune response and dysfunction of the skin barrier, which consists of epithelial cells and tight junctions (TJs). TJs contribute to the barrier function of epithelial and endothelial cells, and are therefore important for regulation of many physiological and pathological events. Zonulin is a 47 kDa protein that increases permeability of the small intestine, has a role in the intestinal innate immune system, and has higher expression in autoimmune diseases in which the dysfunction of TJ proteins plays an essential role. Read More

    Atopic labial pigmentation: a new diagnostic feature in Asian patients with atopic dermatitis.
    Int J Dermatol 2018 Apr 23. Epub 2018 Apr 23.
    Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
    Background: Pigmented lesions on the lips can be caused by physiological or pathological factors, along with exogenous or endogenous factors. Many patients with atopic dermatitis (AD) and labial pigmentation are seen in clinical practice. The aim of our study was to further explore the association of labial pigmentation and AD. Read More

    Secondary Angle Closure due to Crystalline Lens Dislocation in a Patient with Atopic Dermatitis and Chronic Eye Rubbing.
    Case Rep Ophthalmol 2018 Jan-Apr;9(1):197-201. Epub 2018 Mar 22.
    Department of Ophthalmology, William H. Havener Eye Institute, The Ohio State University Medical Center, Columbus, Ohio, USA.
    Purpose: To report an unusual case of ectopia lentis and angle closure in a patient with chronic eye rubbing.

    Methods: A 57-year-old male with a history of poorly controlled atopic dermatitis presented with right eye pain, decreased vision, and an intraocular pressure (IOP) of 55 mm Hg. He had no past history of ocular disease and no reported history of trauma. Read More

    SLIT's Prevention of the Allergic March.
    Curr Allergy Asthma Rep 2018 Apr 21;18(5):31. Epub 2018 Apr 21.
    Allergy Unit, Department of Pediatrics, University of Messina, Messina, Italy.
    Purpose Of Review: The progression of atopic disorders from atopic dermatitis in infants to allergic rhinitis and asthma in children, adolescents, and adults defines the allergy march. Allergen immunotherapy is the only causal treatment altering the immunological mechanism underlying the allergic diseases. The sublingual administration route is more acceptable than the subcutaneous one in pediatric age. Read More

    Thymol attenuates the worsening of atopic dermatitis induced by Staphylococcus aureus membrane vesicles.
    Int Immunopharmacol 2018 Apr 18;59:301-309. Epub 2018 Apr 18.
    Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:
    Staphylococcus aureus membrane vesicles (MVs) aggravate atopic dermatitis (AD) through the delivery of bacterial effector molecules to host cells and the stimulation of inflammatory responses. This study investigated the inhibitory effect of thymol, a phenolic monoterpene found in essential oils derived from plants, on the worsening of AD induced by S. aureus MVs both in vitro and in vivo. Read More

    Allergen-specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model.
    Allergy 2018 Apr 21. Epub 2018 Apr 21.
    Department of Dermatology & Cutaneous Biology Research Institute.
    Background: Several studies have demonstrated that allergen-specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD.

    Methods: NC/Nga mice with induced AD-like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Read More

    Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment.
    PLoS One 2018 20;13(4):e0195960. Epub 2018 Apr 20.
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
    Sweat includes active components and metabolites, which are needed to maintain skin homeostasis. Component changes in sweat derived from atopic dermatitis (AD) have been reported. To investigate the influence of sweat components on the pathogenesis of AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based metabolomic analysis, and linked these features to clinical features of AD. Read More

    New insights into the phenotypes of atopic dermatitis linked with allergies and asthma in children: An overview.
    Clin Exp Allergy 2018 Apr 20. Epub 2018 Apr 20.
    Department of Allergology-Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.
    Atopic dermatitis (AD) is a complex disease with multiple causes and complex mechanistic pathways according to age of onset, severity of the illness, ethnic modifiers, response to therapy, and triggers. A group of difficult-to-manage patients characterized by early-onset AD and severe lifelong disease associated with allergic asthma and/or food allergy, has been identified. In this paper, we focus on these severe phenotypes, analyzing their links with other atopic comorbidities, and taking into account the results from recent cohort studies and meta-analyses. Read More

    Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I.
    J Eur Acad Dermatol Venereol 2018 May;32(5):657-682
    Christine Kühne Center for Allergy Research and Education CK-CARE, Davos, Switzerland.
    This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions. Read More

    An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis.
    Int J Dermatol 2018 Apr 20. Epub 2018 Apr 20.
    Universidade do Vale do Rio dos Sinos, São Leopoldo, RS, Brasil.
    Acne and Atopic Dermatitis (AD) are chronic inflammatory skin conditions with severe impact on a patient's life. Current treatments are related to adverse effects and do not represent a definitive cure. The present paper reviews the alterations in skin microbiome, specifically in acne and AD, and aims in searching for potential treatments based on benefic microorganisms, called probiotics. Read More

    Current Management of Moderate-to-Severe Atopic Dermatitis: A Survey of Allergists, Pediatric Allergists and Dermatologists in Korea.
    Allergy Asthma Immunol Res 2018 May;10(3):253-259
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
    Purpose: There is an unmet need for the treatment of moderate-to-severe atopic dermatitis (AD), leading to variation in management strategies. To investigate distinct features and treatment modalities according to physicians' specialties, we collected data on the current treatment approach to moderate-to-severe AD among allergists, pediatric allergists and dermatologists in Korea.

    Methods: This questionnaire-based study was administered to physicians from the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI), Korean Academy of Pediatric Allergy and Respiratory Disease (KAPARD), and Korean Atopic Dermatitis Association (KADA). Read More

    Differences in Genetic Variations Between Treatable and Recalcitrant Atopic Dermatitis in Korean.
    Allergy Asthma Immunol Res 2018 May;10(3):244-252
    Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Purpose: Variations in barrier- or immune response-related genes are closely related to the development of atopic dermatitis (AD). This study was designed to identify genetic variations and clinical features to predict 'recalcitrant AD.'

    Methods: AD patients were classified as treatable and recalcitrant. Read More

    Significance of Skin Barrier Dysfunction in Atopic Dermatitis.
    Allergy Asthma Immunol Res 2018 May;10(3):207-215
    Department of Pediatrics, National Jewish Health, Denver, CO, USA.
    The epidermis contains epithelial cells, immune cells, and microbes which provides a physical and functional barrier to the protection of human skin. It plays critical roles in preventing environmental allergen penetration into the human body and responsing to microbial pathogens. Atopic dermatitis (AD) is the most common, complex chronic inflammatory skin disease. Read More

    Allergen immunotherapy in people, dogs, cats and horses - differences, similarities and research needs.
    Allergy 2018 Apr 19. Epub 2018 Apr 19.
    School of Veterinary Medicine, University of Wisconsin, Madison, WI, 53706, USA.
    In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Read More

    Eyelash length for the diagnosis of atopic dermatitis and ichthyosis vulgaris in children-a case control study.
    Eur J Pediatr 2018 Apr 19. Epub 2018 Apr 19.
    Department of Dermatology, MVP's Dr. VasantraoPawar Medical College, Flat no. 11, Manomay Apartment, Savatanagar CIDCO, Nashik, Maharashtra, 422008, India.
    Eyelash trichomegaly (ET) is increased length (≥ 12 mm), curling, pigmentation, or thickness of eyelashes. Among acquired causes, allergic diseases and atopic dermatitis (AD) have been found to be associated with eyelash trichomegaly especially in children; however, to date, this claim has not been studied in detail. To compare the eyelash lengths of AD and ichthyosis vulgaris (IV) patients with those of age- and sex-matched patients with unrelated skin disorders, we measured (with a digital Vernier caliper) and compared the eyelash lengths of AD (n = 58) and IV (n = 31) patients to those of age- and sex-matched patients with unrelated skin disorders (n = 178). Read More

    Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography.
    Biomed Opt Express 2018 Apr 29;9(4):2001-2017. Epub 2018 Mar 29.
    Department of Electronic and Electrical Engineering, University of Sheffield, Sheffield, UK.
    Measurement of sub-clinical atopic dermatitis (AD) is important for determining how long therapies should be continued after clinical clearance of visible AD lesions. An important biomarker of sub-clinical AD is epidermal hypertrophy, the structural measures of which often make optical coherence tomography (OCT) challenging due to the lack of a clearly delineated dermal-epidermal junction in AD patients. Alternatively, angiographic OCT measurements of vascular depth and morphology may represent a robust biomarker for quantifying the severity of clinical and sub-clinical AD. Read More

    Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology.
    J Am Acad Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    University of California, Irvine, Department of Dermatology, Irvine, CA, 92697.
    Background: Janus kinase inhibitors (JAKi) have attracted attention for their role in treating inflammatory disorders. This new class of biologics has the potential to significantly impact the field of dermatology, especially with the development of topical formulations.

    Objective: To summarize published evidence on the efficacy, safety, and tolerability of topical JAKi in the treatment of inflammatory skin conditions. Read More

    Langerhans and inflammatory dendritic epidermal cells in atopic dermatitis are tolerized towards TLR2 activation.
    Allergy 2018 Apr 19. Epub 2018 Apr 19.
    Department of Dermatology and Allergy, and Christine Kühne-Center for Allergy Research and Education (CK-CARE), University of Bonn, Germany.
    Background: The skin of atopic dermatitis (AD) patients presents a significant dysbalance of the microbiome with a high colonization by Staphylococcus aureus (S. aureus) which positively correlates with the severity of the disease.

    Objective: Understanding the role of epidermal dendritic cells as link between the innate and the adaptive immune systems in AD. Read More

    Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).
    Br J Dermatol 2018 Apr 19. Epub 2018 Apr 19.
    University of São Paulo, Campinas, Brazil.
    This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12-14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement of the core domain of quality of life (QoL) in children. Read More

    Psoriatic Arthritis and Nail Psoriasis in a Patient with Concomitant Atopic Dermatitis.
    Case Rep Dermatol Med 2018 18;2018:4125856. Epub 2018 Feb 18.
    Department of Rheumatology, Hutt Hospital, Lower Hutt, New Zealand.
    Coincidence of psoriasis and atopic dermatitis (AD) is considered to be very rare, as a result of the different underlying immunopathology. This case report describes a patient with long history of atopy and AD who developed psoriatic nail changes and psoriatic arthritis (PsA). The patient's skin, however, revealed only eczematous lesions without manifestation of psoriasis. Read More

    The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin.
    Clin Cosmet Investig Dermatol 2018 6;11:141-148. Epub 2018 Apr 6.
    Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan.
    Objective: Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases. Read More

    Heterogeneous ceramide distributions alter spatially resolved growth of on human stratum corneum.
    J R Soc Interface 2018 Apr;15(141)
    Department of Biomedical Engineering, Binghamton University, 4400 Vestal Parkway East, Binghamton, NY 13902, USA
    Contemporary studies have revealed dramatic changes in the diversity of bacterial microbiota between healthy and diseased skin. However, the prevailing use of swabs to extract the microorganisms has meant that only population 'snapshots' are obtained, and all spatially resolved information of bacterial growth is lost. Here we report on the temporospatial growth of on the surface of the human stratum corneum (SC); the outermost layer of skin. Read More

    The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice.
    Int Arch Allergy Immunol 2018 Apr 18. Epub 2018 Apr 18.
    Background: Although immunosuppressants for therapy of atopic dermatitis (AD) are still being sought, proteasome inhibitors are also potential candidates for the treatment of AD. Proteasome inhibitors exert various effects by blocking proteasomal degradation and help regulate processes such as apoptosis induction via caspase-9, cell cycle progression via cyclins, NF-κB inactivation via IκB, and downregulation of antigen cross-presentation. The cells targeted by proteasome inhibitors are therefore activated cells undergoing proliferation or differentiation, and antigen-presenting cells carrying out protein degradation. Read More

    Atopic keratoconjunctivitis: A diagnostic dilemma-a case report.
    Medicine (Baltimore) 2018 Apr;97(16):e0372
    Beijing Tongren Eye Centre, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, R.P. China.
    Rationale: Atopic keratoconjunctivitis (AKC) remains a difficult diagnosis despite advances in imaging technologies. This is a case study of the diagnostic and treatment course for a patient with AKC.

    Patient Concerns: A 15-year-old male complained of progressively increasing pain, redness, watering and blurred vision in the right eye. Read More

    Phase 1 studies to assess the safety, tolerability and pharmacokinetics of JTE-052 (a novel Janus kinase inhibitor) ointment in Japanese healthy volunteers and patients with atopic dermatitis.
    J Dermatol 2018 Apr 17. Epub 2018 Apr 17.
    Clinical Development Department, Pharmaceutical Division, Japan Tobacco Inc., Tokyo, Japan.
    The purpose of the present two phase 1 studies was to assess the safety, tolerability and pharmacokinetics for topical application of a novel Janus kinase (JAK) inhibitor, JTE-052, in Japanese healthy adult male volunteers and Japanese adult patients with atopic dermatitis (AD). Additionally, exploratory investigation was performed on the efficacy for disease severity and pruritus score in AD patients. In the QBX1-1 study, the cutaneous safety of JTE-052 ointment by a patch test and a photo patch test was assessed in an intra-individual comparative study using placebo ointment, white petrolatum and non-application as comparators. Read More

    Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population-based study.
    Int J Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Health Services Administration, China Medical University, Taichung, Taiwan.
    Background: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. Read More

    A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart.
    Sci Rep 2018 Apr 16;8(1):5988. Epub 2018 Apr 16.
    Nucleic Acid Regulation (Yoshindo) Joint Research Laboratory, Department of Biotechnology, Osaka University, Osaka, Japan.
    Drug development involves pharmacometric experiments in animals. Such experiments should limit animal pain and stress. Conventional murine models of atopic dermatitis (AD) used in drug development are generated by weekly painting of hapten on dorsal skin for 5 weeks. Read More

    Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study.
    Allergol Int 2018 Apr 13. Epub 2018 Apr 13.
    Department of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
    Background: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires.

    Methods: Of 46,648 invited children, we analyzed 9954 (21. Read More

    Jageum-Jung improves 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice and suppresses pro-inflammatory chemokine production by inhibiting TNF-α/IFN-γ-induced STAT-1 and NFκB signaling in HaCaT cells.
    J Ethnopharmacol 2018 Apr 14;221:48-55. Epub 2018 Apr 14.
    Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea. Electronic address:
    Ethnopharmacological Relevance: Jageum-Jung (JGJ) is an oriental herbal formula comprising five herbs (Melaphis chinensis Bell, Cremastra variabilis Nakai, Knoxia valerianoides Thorel, Euphorbia lathyris L., and Moschus moschiferus L.). Read More

    The Major Orphan Forms of Ichthyosis are Characterized by Systemic T-Cell Activation and Th-17/Tc-17/Th-22/Tc22 Polarization in Blood.
    J Invest Dermatol 2018 Apr 13. Epub 2018 Apr 13.
    The ichthyoses are rare skin disorders with immune and barrier aberrations. Identifying blood phenotypes may advance targeted-therapeutics.We aimed to compare frequencies of skin homing/CLA vs. Read More

    Incidence of pediatric atopic dermatitis following thymectomy: a Danish register study.
    Allergy 2018 Apr 16. Epub 2018 Apr 16.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.
    T cell receptor gene rearrangement and T cell maturation occur in the thymus. Thymic involution begins at 1 year of age and progresses with approximately 3% per year until young adulthood. Newborns undergoing open-heart surgery have all or most of their thymus removed to facilitate cannulation of vessels, hence reducing the number of circulating CD3 , CD4 and CD8 Th cells. Read More

    Alloknesis and hyperknesis - mechanisms, assessment methodology and clinical implications of itch sensitization.
    Pain 2018 Apr 11. Epub 2018 Apr 11.
    Laboratory of Experimental Cutaneous Pain Research, SMI, Faculty of Medicine, Aalborg University, Denmark.
    Itch and pain share numerous mechanistic similarities. Patients with chronic itch conditions (for instance atopic dermatitis or neuropathic itch), often experience symptoms such as mechanical alloknesis and hyperknesis. These dysesthesias are analoguous to the pain-associated phenomena allodynia and hyperalgesia, which are often observed, e. Read More

    [Predictive value of cord blood 25(OH)D3 for early infantile atopic dermatitis].
    Zhongguo Dang Dai Er Ke Za Zhi 2018 Apr;20(4):303-307
    Department of Pediatrics, Shanghai Fifth People′s Hospital Affiliated to Fudan University, Shanghai 200240, China.
    Objective: To explore the predictive value of cord blood 25(OH)D [25(OH)D] for infantile atopic dermatitis (AD), and to provide a reference for primary prevention of early infantile AD.

    Methods: The neonates born from July to September, 2015 were enrolled. The cord blood samples were collected at birth to measure the level of 25(OH)D. Read More

    Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines.
    Int Immunopharmacol 2018 Apr 12;59:209-216. Epub 2018 Apr 12.
    Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:
    Atopic dermatitis (AD) is a common chronic inflammatory skin disorder afflicting from infancy to adults with itching, scratching, and lichenification. We aimed to investigate the effects of esculetin from Fraxinus rhynchophylla on atopic skin inflammation. For induction of atopic skin inflammation, we exposed the ears of female BALB/c mice to house dust mite (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) for 4 weeks. Read More

    Identification of pyruvate kinase as a novel allergen in whiteleg shrimp (Litopenaeus vannamei) by specific-IgE present in patients with shrimp allergy.
    Food Chem 2018 Aug 21;258:359-365. Epub 2018 Mar 21.
    Department of Food Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. Electronic address:
    Food allergy is one of the most important health issues worldwide. In Taiwan, current literature suggests shrimps and crabs are the most common causes of food allergy, and are frequently associated with acute allergic reactions such as urticaria, atopic dermatitis, and asthma. However, knowledge regarding the shrimp allergens remains limited. Read More

    Birch pollen-related foods can cause late eczematous reactions in patients with atopic dermatitis.
    Allergy 2018 Apr 13. Epub 2018 Apr 13.
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
    Background: Previous studies have indicated that in patients with atopic dermatitis (AD) and birch pollen allergy related foods are able to cause a late eczematous response. However, the relevance of AD worsening by ingestion of birch pollen-related foods is still a matter of debate.

    Objective: The purpose of this retrospective study was to determine how frequently birch pollen-related foods induce a deterioration of eczema. Read More

    A new flavonoid from Stellera chamaejasme L., stechamone, alleviated 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in a murine model.
    Int Immunopharmacol 2018 Apr 10;59:113-119. Epub 2018 Apr 10.
    College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea. Electronic address:
    Stellera chamaejasme L. (family Thymelaeaceae), also known as 'Langdu', has been traditionally used to treat of skin-related diseases, such as, psoriasis and skin ulcers. The aim of this study was to identify the biologically active component of S. Read More

    Asian atopic dermatitis serum is characterized by Th2/Th22-activation, highly correlated with non-lesional skin measures.
    J Allergy Clin Immunol 2018 Apr 10. Epub 2018 Apr 10.
    Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA. Electronic address:
    Asian AD serum is characterized by prominent Th2 and Th22 signatures that correlate with the non-lesional skin profile, suggesting that serum phenotyping can serve as a surrogate for assessing disease extent beyond apparent AD lesions. Read More

    A case of atopic dermatitis caused by infection.
    Clin Mol Allergy 2018 10;16:10. Epub 2018 Apr 10.
    3School and Operative Unit of Allergy and Clinical Immunology Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Background: Parasite infections stimulate total and specific IgE production that, in the case of infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar symptoms, such as infection. is a large nematode that causes abdominal pain, nausea, vomiting, bloating, anorexia and intermittent diarrhoea. Read More

    Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.
    Matrix Biol 2018 Apr 9. Epub 2018 Apr 9.
    Laboratory of Connective Tissues Biology, GIGA-R, University of Liege, 4000 Sart Tilman, Belgium.
    Since its first description, ADAMTS14 has been considered as an aminoprocollagen peptidase based on its high similarity with ADAMTS3 and ADAMTS2. As its importance for procollagen processing was never experimentally demonstrated in vivo, we generated Adamts14-deficient mice. They are healthy, fertile and display normal aminoprocollagen processing. Read More

    Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis.
    Int J Mol Sci 2018 Apr 12;19(4). Epub 2018 Apr 12.
    Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.
    Atopic dermatitis (AD) is a common inflammatory skin disease. Recent studies have revealed the involvement of T helper (Th)2 cytokines including Interleukin 4 (IL-4) in the pathogenesis of AD. Since epidermal Langerhans cells (LCs) and dermal myeloid dendritic cells (DCs) produce CCL17 and CCL22 that chemoattract Th2 cells, interfering with CCL17 and CCL22 production from LCs and dermal myeloid DCs may be beneficial in the treatment of AD. Read More

    Anti-Inflammatory Effects of a Mixture of Lactic Acid Bacteria and Sodium Butyrate in Atopic Dermatitis Murine Model.
    J Med Food 2018 Mar 20. Epub 2018 Mar 20.
    1 Department of Animal Resources Technology, Gyeongnam National University of Science and Technology , Jinju, Korea.
    Atopic dermatitis is a chronic and recurrent inflammatory skin disease. Recently, probiotics have been shown to suppress allergic symptoms through immunomodulatory responses. In the present study, combinatorial effects on allergic symptoms were identified in BALB/c mice fed with a mixture of four species of probiotics, Bifidobacterium lactis, Lactobacillus casei, Lactobacillus rhamnosus, and Lactobacillus plantarum, and sodium butyrate. Read More

    S1 Guidelines - Dermatoses associated with dermal lymphostasis.
    J Dtsch Dermatol Ges 2018 Apr;16(4):512-523
    Former Department of Dermatology, Allergology, Phlebology, and Lymphology, Sanaderm Hospital, Bad Mergentheim, Germany.
    The objective of the present S1 guidelines is to present current knowledge about dermatologically relevant diseases associated with localized dermal lymphostasis, thus facilitating their early detection, diagnostic workup, and targeted treatment. Whenever possible, treatment should be based on stage-appropriate and clearly defined algorithms. The numerous issues regarding differential diagnosis and treatment clinicians are confronted with in everyday clinical practice seem to warrant the publication of up-to-date guidelines. Read More

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