116,710 results match your criteria Dermatitis Artefacta


Health utility scores of atopic dermatitis in US adults.

J Allergy Clin Immunol Pract 2018 Dec 8. Epub 2018 Dec 8.

Oregon Health & Science University, Portland, OR.

Background: The impact of atopic dermatitis (AD) on health related quality of life and health utility in the United States adult population is not well-established.

Objectives: To determine the health utilities and quality of life adjusted years (QALYs) lost in adults with vs. without AD among the US population. Read More

View Article
December 2018

Pediatric Dermatology - critical approach to the new treatments.

Dermatol Ther 2018 Dec 7:e12801. Epub 2018 Dec 7.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health.

The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. Read More

View Article
December 2018

Allergic contact dermatitis due to undecylenic acid in an antifungal nail solution.

Contact Dermatitis 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Hospital General Universitario de Alicante. Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

Undecylenic acid (CAS no. 112-38-9) has antifungal and antibacterial effects. For this reason, it is used along with imidazole antifungals. Read More

View Article
December 2018

Multiple chemical sensitivity syndrome is not caused by contact allergy.

Contact Dermatitis 2018 Dec 10. Epub 2018 Dec 10.

Department of Cutaneous Allergy, St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust, London, UK.

There is a lack of published data on the role of patch testing in patients with so-called multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI). This disputed chronic condition is characterised by symptoms that the affected person attributes to low-level exposures to commonly used chemicals. Symptoms are typically vague and non-specific and may include fatigue, headaches, nausea, dizziness, a sensation of skin burning or pain. Read More

View Article
December 2018
1 Read

Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

View Article
December 2018
1 Read

Dermatitis and alopecia in a patient treated with dupilumab: a new adverse effect?

Clin Exp Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Department of Dermatology, Puerta de Hierro Hospital, C/Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain.

View Article
December 2018

Comparison of demographic data, disease severity and response to treatment, between dogs with atopic dermatitis and atopic-like dermatitis: a retrospective study.

Vet Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Veterinary Clinical Sciences and Surgery, Universidade Federal de Minas Gerais, 6627 Antônio Carlos Ave, Belo Horizonte, 31270-901, Brazil.

Background: Limited information is available describing the features of canine atopic-like dermatitis (ALD) compared with atopic dermatitis (AD).

Objectives: To compare demographic data, disease severity and response to therapy between ALD and AD dogs.

Animals: Two hundred and fifty-three atopic dogs with intradermal and serum allergen-specific IgE test results were selected retrospectively. Read More

View Article
December 2018

JAK Inhibitors for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 5 E. 98th Street, New York, NY, 10029, USA.

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying degrees of Th1 and Th17 among various subtypes. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and spleen tyrosine kinase (SYK) pathways are involved in signaling of several AD-related cytokines, such as IFN-γ, IL-4, IL-13, IL-31, IL-33, IL-23, IL-22, and IL-17, mediating downstream inflammation and barrier alterations. Read More

View Article
December 2018
1 Read

Draft Genome Sequences of Five Methicillin-Sensitive Staphylococcus aureus Isolates from Skin Lesions in Patients with Atopic Dermatitis in the Russian Federation.

Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.

Department of Genetics and Molecular Biology of Bacteria, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of Russian Federation, Moscow, Russia.

We present here draft genome sequences of five Staphylococcus aureus strains obtained from children suffering from atopic dermatitis. The strains were determined to be of five different sequence types (sequence type 1 [ST1], ST7, ST8, ST15, and ST101) and carried a unique combination of superantigen-like protein (SSL) and serine protease genes. Read More

View Article
October 2018

Topically applied low-dose calcitriol ameliorates atopic eyelid dermatitis.

JAAD Case Rep 2019 Jan 27;5(1):5-6. Epub 2018 Nov 27.

Department of Dermatology, University of Lübeck, Lübeck, Germany.

View Article
January 2019

Dismissing the fallacies of childhood eczema management: case scenarios and an overview of best practices.

Drugs Context 2018 3;7:212547. Epub 2018 Dec 3.

Department of Pediatrics, The University of Calgary, Alberta Children's Hospital, Calgary, Alberta, Canada.

Background: Eczema or atopic dermatitis (AD) is a common relapsing childhood dermatologic illness. Treatment of AD is primarily topical with emollients and corticosteroid/calcineurin inhibitor, which is efficacious for the majority of patients. However, AD is often complicated and difficult to manage in many Asian cities. Read More

View Article
December 2018

Acquired diffuse slate-grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients.

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Henna is a vegetable hair dye that can be used by individuals who are sensitized to oxidative dyes due to low allergenicity. The reported incidence of slate-grey facial dyspigmentation following the use of henna hair dye is extremely rare. This study aimed to identify the clinical, dermoscopic, and histopathological features of slate-grey facial dyspigmentation following the use of henna hair dye in Korean patients. Read More

View Article
October 2018

Clinical characteristics and genetic variation in atopic dermatitis patients with and without allergic contact dermatitis.

Eur J Dermatol 2018 Oct;28(5):637-643

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.

In patients with atopic dermatitis (AD), the risk of contact sensitization may be higher as the disrupted skin barrier may increase the penetration of contact allergens. Therefore, it is necessary to screen for concurrent allergic contact dermatitis (ACD) in AD patients. To identify the clinical characteristics and genetic variation in AD patients with concurrent ACD. Read More

View Article
October 2018

Long-lasting allergic contact dermatitis to methylisothiazolinone misdiagnosed as atopic dermatitis.

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

CHU Lyon-Sud, Department of Allergology and Clinical Immunology, Lyon, France, Lyon University, Lyon, France, CIRI-INSERM U1111, Lyon, France.

View Article
December 2018

Rituximab revisited: successful management of severe childhood atopic dermatitis.

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Hospital de Santo António dos Capuchos.

View Article
December 2018

Alopecia Areata in Severe Atopic Dermatitis Treated With Dupilumab.

J Investig Allergol Clin Immunol 2018 Dec;28(6):420-421

Allergy Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.

View Article
December 2018

Structural Basis of Interleukin-5 Inhibition by the Small Cyclic Peptide AF17121.

J Mol Biol 2018 Dec 7. Epub 2018 Dec 7.

Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institute of the University Wuerzburg, Julius-von-Sachs-Platz 2, D-97082, Wuerzburg, Germany. Electronic address:

Interleukin-5 (IL-5) is a T2 cytokine involved in many aspects of eosinophil life. Eosinophilic granulocytes play a pathogenic role in the progression of atopic diseases, such as allergy, asthma and atopic dermatitis and hypereosinophilic syndromes. Here, eosinophils upon activation degranulate leading to the release of proinflammatory proteins and mediators stored in intracellular vesicles termed granula thereby causing local inflammation, which when persisting leads to tissue damage and organ failure. Read More

View Article
December 2018

Antibiotic choice and MRSA rate in children who are hospitalized for atopic dermatitis.

Ann Allergy Asthma Immunol 2018 Dec 7. Epub 2018 Dec 7.

Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:

View Article
December 2018

Brief Report: Pembrolizumab in Combination With Erlotinib or Gefitinib as First-Line Therapy for Advanced Non-Small-Cell Lung Cancer With Sensitizing EGFR Mutation.

J Thorac Oncol 2018 Dec 4. Epub 2018 Dec 4.

South Texas Accelerated Research Therapeutics, 4383 Medical Dr, San Antonio, TX 78229, USA.

Introduction: Anti-EGFR agents are standard treatments for patients with EGFR-mutant advanced NSCLC. The feasibility of combining erlotinib or gefitinib with anti-PD1 immunotherapy pembrolizumab was evaluated in the phase 1/2 KEYNOTE-021 (NCT02039674) study.

Methods: Adults with previously untreated stage IIIB/IV EGFR-mutant NSCLC were treated with pembrolizumab 2 mg/kg IV every 3 weeks plus oral erlotinib 150 mg daily in cohort E or oral gefitinib 250 mg daily in cohort F, using a 3+3 design with cohort expansion. Read More

View Article
December 2018

mTOR inhibitors in pediatric liver transplant recipients.

Clin Res Hepatol Gastroenterol 2018 Dec 6. Epub 2018 Dec 6.

Swiss center for liver disease in children, university hospitals Geneva, Geneva, Switzerland.

Background: During the past decade, mTOR inhibitors (mTORi), everolimus and sirolimus, have been increasingly used after adult liver transplantation (LT). The aim of the present study was to describe the use of mTORi in pediatric LT recipients.

Methods: All pediatric LT recipients who received mTORi before December 2017 from 4 European pediatric LT centers were included and analyzed. Read More

View Article
December 2018

A Phase 2 Randomized Trial of Apremilast in Patients With Atopic Dermatitis.

J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Icahn School of Medicine at the Mount Sinai Medical Center, New York, NY, USA.

Background: and Purpose: A phase 2, double-blind, placebo-controlled trial evaluated apremilast efficacy, safety, and pharmacodynamics in adults with moderate to severe atopic dermatitis (AD).

Study Design: and Methods: Patients were randomized to placebo, apremilast 30 mg BID (APR30), or apremilast 40 mg BID (APR40) for 12 weeks. During Weeks 12-24, all patients received APR30 or APR40. Read More

View Article
December 2018

Consensus Statement on the Psychological Needs of Patients With Chronic Inflammatory Skin Diseases.

Actas Dermosifiliogr 2018 Dec 5. Epub 2018 Dec 5.

Servicio de Dermatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España.

Objective: To establish recommendations to determine, identify, and manage the psychological and emotional needs of patients with chronic inflammatory skin diseases in clinical practice.

Methods: A guided discussion was held at meeting of a nominal group of expert dermatologists and psychologists on the psychological and emotional needs of patients with chronic inflammatory skin diseases, how to manage these cases, and which referral criteria to employ. Based on the results of the discussion, and with the aid of a patient focus group and a review of the literature, a master document was drawn up with recommendations for discussion. Read More

View Article
December 2018

TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.

J Dermatol Sci 2018 Nov 26. Epub 2018 Nov 26.

Department of Dermatology, University of California, Davis, CA, USA. Electronic address:

Background: Transient Receptor Potential Vanilloid 1 (TRPV1) is known to mediate itch and neurogenic inflammation, but the role of TRPV1 in psoriasiform dermal inflammation is poorly understood.

Objective: To investigate the function of TRPV1 in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.

Methods: Following daily treatment of topical IMQ cream for consecutive 5 days in C57BL/6 wide-type (WT) and TRPV1 gene knockout (KO) mice, we assessed the psoriasis severity index (PSI) scores, transepidermal water loss (TEWL), dermal inflammatory infiltrates, as well as gene expression levels for psoriasis related genes in mouse skin lesions. Read More

View Article
November 2018

Adverse Drug Events as a Reason for Adult Hospitalization: A Nationwide Readmission Study.

Ann Pharmacother 2018 Dec 10:1060028018818571. Epub 2018 Dec 10.

1 Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Background: Adverse drug events (ADEs) are common; however, there are limited data on the impact of ADEs on post-discharge outcomes.

Objectives: To identify ADEs responsible for readmission within 6 months of hospital discharge in the United States. Secondary objectives were to examine whether demographic, clinical, and hospital characteristics were associated with ADE readmission. Read More

View Article
December 2018

Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

Glycosaminoglycans (GAGs) are linear, highly negatively charged carbohydrate chains present in connective tissues. Chondroitin sulfate (CS) and heparin (Hep) are also found in the numerous secretory granules of mast cells (MC), tissue immune cells involved in allergic and inflammatory reactions. CS and Hep may inhibit secretion of histamine from rat connective tissue MC, but their effect on human MC remains unknown. Read More

View Article
December 2018

The Prevalence of Atopic Dermatitis and Chronic Spontaneous Urticaria are Associated with Parental Socioeconomic Status in Adolescents in China.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Xiangya Hospital, 410008 Changsha, China.

The association of atopic dermatitis and chronic spontaneous urticaria with socioeconomic status has been little studied. The aim of this study was to investigate the prevalence of skin diseases and their association with socioeconomic status in adolescents in China. A cross-sectional study was conducted at a comprehensive university. Read More

View Article
December 2018
3 Reads

Novel Paranannizziopsis species in a Wagler's viper (Tropidolaemus wagleri), tentacled snakes (Erpeton tentaculatum), and a rhinoceros snake (Rhynchophis boulengeri) in a zoological collection.

Med Mycol 2018 Dec 6. Epub 2018 Dec 6.

Mycology Unit, Facultat de Medicina i Ciències de la Salut and IISPV, University Rovira i Virgili, Reus, Spain.

We report several cases of fungal infections in snakes associated with a new species within the genus Paranannizziopsis. Three juvenile Wagler's vipers (Tropidolaemus wagleri) presented with skin abnormalities or ulcerative dermatitis, and two snakes died. Histologic examination of skin from the living viper revealed hyperplastic, hyperkeratotic, and crusting epidermitis with intralesional fungal elements. Read More

View Article
December 2018
3 Reads

Letter to the Editor: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. JEADV 2018, 32, 850-878. doi.org/10.1111/jdv.14888.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Head Research & Head Outpatient Clinic, Department of Dermatology, University Hospital Zürich, Switzerland.

We read with interest and with full consent the new consensus-based European guidelines for the treatment of atopic eczema, Part II . However, we would like to comment on the section on microbial textiles where the recommendation to use silk garments with permanent antimicrobial in the management of children with moderate to severe eczema is raised. On the basis of an UK multicenter clinical trial which seemed to show that silk garments with permanent antimicrobial were ineffective in the treatment of children with atopic eczema, the guidelines deny now any clinical benefit of AEGIS-coated silk textiles in children with atopic eczema and this contrary to the previous two guidelines . Read More

View Article
December 2018
2 Reads

Methotrexate in atopic eczema. Comments to: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Allergy and Clinical Immunology Department, Lyon Sud University Hospital, Pierre Bénite, University of Lyon, France.

The recent European guidelines for the treatment of atopic eczema (AE) are a thorough overview of therapeutic opportunities for AE. Among the systemic treatments, we propose to bring further insights on methotrexate (MTX) use in adult AE patients. This article is protected by copyright. Read More

View Article
December 2018
2 Reads

Reply to a correspondence addressing the European guideline for treatment of atopic eczema, functional textiles and the CLOTHES trial.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Department Dermatology and Allergy Biederstein, Technische Universität München Munich, Germany and Christine Kühne-Center for Allergy Research and Education (CK-CARE)Davos.

We have read with interest the respectfully written correspondence by Wüthrich et al. regarding antimicrobial silk textiles for atopic dermatitis (AD) (1). Though it was submitted as a comment to the European consensus-based S2k guidelines on treatment of atopic eczema (2,3), it is discussing in 70% of its length the CLOTHES trial - published in two non-JEADV-publications which we have neither designed nor authored (4,5). Read More

View Article
December 2018
2 Reads

Phenotypes of atopic dermatitis identified by cluster analysis in early childhood.

J Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Atopic dermatitis is a chronic, relapsing, inflammatory skin disease that usually appears in early childhood and develops into a heterogeneous disease during childhood. The clinical course and treatment for atopic dermatitis can differ according to its phenotype and/or endotype. This study aimed to identify clinical phenotypes of atopic dermatitis in early childhood. Read More

View Article
December 2018
2 Reads

Late cutaneous B-Cell pseudolymphoma after an upper-lid gold weight implant.

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Hospital Universitario Príncipe de Asturias, Madrid, Spain.

Upper eyelid gold weight implants are an established tool in the symptomatic treatment of lagophthalmos, the inability to close your eyes completely. Complications associated to this procedure are infrequent. When noted, non-infectious inflammatory reactions corresponding to type IV hypersensitivity reactions are resolved with the removal of the implant. Read More

View Article
December 2018
2 Reads

European Surveillance System on Contact Allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis.

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.

Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.

Objective: To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Read More

View Article
December 2018
4 Reads

[Immunoadsorption in dermatology].

Hautarzt 2018 Dec 5. Epub 2018 Dec 5.

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Autoimmmune bullous diseases are mediated by pathogenetically relevant autoantibodies against components of the epidermis and/or superficial mucous membranes (in pemphigus) and structural proteins of the dermal-epidermal junction (in pemphigoid diseases). Using immunoadsorption (IA), an already well-established procedure in cardiac and rheumatic disorders, antibodies can be removed from the plasma. At present, most data on the adjuvant use of IA in dermatology are derived from patients with severe and/or refractory pemphigus vulgaris or pemphigus foliaceus and also from patients with pemphigoid diseases. Read More

View Article
December 2018

Tri-culture system for pro-hapten sensitizer identification and potency classification.

Technology (Singap World Sci) 2018 Jun 29;6(2):67-74. Epub 2018 Jun 29.

Department of Biomedical Engineering, Rutgers, the State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA.

Allergic contact dermatitis (ACD) is an inflammatory disease that impacts 15-20% of the general population and accurate screening methods for chemical risk assessment are needed. However, most approaches poorly predict pre- and pro-hapten sensitizers, which require abiotic or metabolic conversion prior to inducing sensitization. We developed a tri-culture system comprised of MUTZ-3-derived Langerhans cells, HaCaT keratinocytes, and primary dermal fibroblasts to mimic the cellular and metabolic environments of skin sensitization. Read More

View Article
June 2018
2 Reads

Wash-Line Dermatitis: A Diagnostic Clue.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):12. Epub 2018 Oct 1.

Dr. Jacob is is a Professor of Dermatology in the Dermatology Department at Loma Linda University in Loma Linda, California.

View Article
October 2018

Allergic Contact Dermatitis and Autoeczematization to Proctosedyl® Cream and Proctomyxin® Cream.

Case Rep Dermatol 2018 Sep-Dec;10(3):238-246. Epub 2018 Oct 24.

Department of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Proctosedyl® and Proctomyxin® are two commonly prescribed hemorrhoid therapies. Their topical application to the perianal region may be complicated by a local allergic contact dermatitis and subsequent autoeczematization reaction. We present three cases of an autoeczematization (ID) reaction to varying topical allergens found in Proctosedyl®/Proctomyxin®. Read More

View Article
October 2018
1 Read

Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation.

Cell Death Dis 2018 Dec 5;9(12):1181. Epub 2018 Dec 5.

Department of Immunology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Mechanical damage on the skin not only affects barrier function but also induces various immune responses, which trigger or exacerbate skin inflammation. However, how mechanical damage-induced skin inflammation is regulated remains incompletely understood. Here, we show that keratinocytes express the long-chain fatty-acid elongase Elovl6. Read More

View Article
December 2018
1 Read

The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA).

J Toxicol Sci 2018 ;43(12):741-749

Department of Dermatology, Tohoku University Graduate School of Medicine.

In all current in vitro skin sensitisation assays, DMSO is used to dissolve water-insoluble chemicals. However, our previous study suggested the superiority of the modified IL-8 Luc assay (mIL-8 Luc), in which X-VIVO 15 is used to dissolve chemicals, over the original assay using DMSO (oIL-8 Luc). In this study, to confirm the superiority of the mIL-8 Luc, we first increased the number of chemicals examined and demonstrated the superiority of the mIL-8 Luc, in which the mIL-8 Luc provided 87. Read More

View Article
January 2018

Probable Roles of Coagulation Cascade and Fibrinolysis System in the Development of Allergic Rhinitis.

Am J Rhinol Allergy 2018 Dec 6:1945892418816015. Epub 2018 Dec 6.

3 Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Background: Dysregulation of the coagulation cascade and fibrinolysis system may play an etiologic role in many diseases. Allergic diseases such as bronchial asthma, atopic dermatitis, and conjunctivitis are also associated with fibrin accumulation caused by a change in hemostasis. However, only a few studies have dealt with the relationship between allergic rhinitis (AR) and the coagulation system. Read More

View Article
December 2018

Clinical and instrumental evaluation of the efficacy of an emollient cream and a cleansing cream in the management of mild to moderate adulthood atopic dermatitis.

G Ital Dermatol Venereol 2018 12;153(6):855-859

Department of Clinical Pathology Cristo Re Hospital, Rome, Italy.

Background: Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disorder which may persist or directly start in adults. This is an open-label prospective study to clinically and instrumentally evaluate the effects of an emollient glycerin and paraffin-based cream and a gentle refatting cleanser in the management of mild to moderate adulthood AD.

Methods: Fifty adult patient with mild to moderate AD were recruited at the Professional Dermatology and Allergology Outpatient Clinic of the San Gallicano Dermatological Institute of Rome, between November 2016 and January 2018. Read More

View Article
December 2018

Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

Background: Adenoid cystic carcinoma (ACC) are more common in the minor salivary glands (MiSGs) than the major salivary glands, and are characterized by slow tumor progression and frequently local recurrence. The main treatment option is surgery followed by combined radiotherapy.

Methods: A retrospective analysis contained 67 patients with ACC of MiSGs in the oral cavity who underwent surgery followed by radiotherapy. Read More

View Article
December 2018
2 Reads

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.

Ann Allergy Asthma Immunol 2018 Nov 30. Epub 2018 Nov 30.

The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA; Department of Dermatology, the Laboratory for Inflammatory Skin Diseases and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

View Article
November 2018

Preventing the development of asthma: stopping the allergic march.

Curr Opin Allergy Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.

Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: To describe important precipitants of asthma and allergic disease, to highlight the links between these triggers and modifications within the immune system, and to examine innovative research regarding asthma prevention with focus on attenuating the atopic march.

Recent Findings: Allergen avoidance, allergen immunotherapy, IgE antagonists, prevention and treatment of respiratory infections, as well as management of gastrointestinal and respiratory dysbiosis have been considered as strategies in asthma prevention. Antenatal vitamin D supplementation in expectant mothers and aggressive control of atopic dermatitis to prevent the development of other allergic conditions were carefully studied as well. Read More

View Article
November 2018

Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome.

Exp Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Dermatology, University of Alabama at Birmingham (UAB), Birmingham, AL.

Background: Studies have begun to investigate the complex relationship between host and microorganisms in non-infectious pathologies such as acne, atopic dermatitis, and psoriasis. Though the skin is exposed to environmental stressors such as ultraviolet radiation (UVR), no studies exist examining the effects of both UVA and UVB on the skin microbiome.

Objective: To test the effect of UVA and UVB on human skin microbiome. Read More

View Article
December 2018

Neurocognitive function in moderate-severe pediatric atopic dermatitis: A case-control study.

Pediatr Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Division of Dermatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois.

Background/objectives: Epidemiological studies have shown an increased prevalence of attention deficit hyperactivity disorder (ADHD) in children with atopic dermatitis (AD), but many of the features of ADHD may occur as a result of the poor sleep and itch distraction associated with AD.

Methods: A case-control study was performed in children aged 6-17 years with moderate/severe AD compared with age-/sex-matched healthy controls. Participants were screened for ADHD using Vanderbilt assessments. Read More

View Article
December 2018

Neonatal skin care: Developments in care to maintain neonatal barrier function and prevention of diaper dermatitis.

Pediatr Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Skin Health Alliance, London, UK.

Background: Understanding the importance of the barrier function of the skin of preterm and term neonates is crucial in effective neonatal skin and diaper care. This literature search aimed to review the development of different practices in neonatal care to maintain skin barrier function, in turn preventing diaper dermatitis.

Methods: We performed two quantitative literature searches of English language studies: an initial literature search of studies published in the last 5 years was conducted using Cinahl, Medline, Embase, British Nursing Index, and DelphiS, followed by a second search of publications from 1990 to 2017 using the National Institute of Clinical Excellence Health Databases Advanced Search using key words, synonyms, and Boolean phrasing. Read More

View Article
December 2018

CORRIGENDUM.

Authors:

Contact Dermatitis 2019 Jan;80(1):76

View Article
January 2019

Tertiary prevention of occupational skin diseases: Prevalence of allergic contact dermatitis and pattern of patch test results.

Contact Dermatitis 2019 Jan 28;80(1):35-44. Epub 2018 Aug 28.

Lower-Saxonian Institute of Occupational Dermatology at the Georg-August University, Göttingen, Germany, and at the University of Osnabrück, Osnabrück, Germany.

Background: Allergic contact dermatitis (ACD) is one of the most common occupational skin diseases (OSDs). Its prevalence and the causative allergens differ between occupations.

Objectives: To evaluate the prevalence of ACD and the pattern of patch test results of patients taking part in a tertiary individual prevention programme (TIP) for OSD in Germany. Read More

View Article
January 2019
1 Read