118,378 results match your criteria Dermatitis : contact atopic occupational drug : official journal of the American Contact Dermatitis Society North American Contact Dermatitis Group[Journal]


Evaluating crisaborole as a treatment option for atopic dermatitis.

Expert Opin Pharmacother 2019 Apr 19:1-7. Epub 2019 Apr 19.

d Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.

Introduction: Atopic dermatitis (AD) is a chronic and recurrent disease presenting with eczematous lesions and pruritus. It impacts patient and family quality of life, increases morbidity, and accounts for large health-care expenditures. Although nonpharmacologic, topical, and systemic treatments exist, management of AD remains challenging due to limited treatment options. Read More

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http://dx.doi.org/10.1080/14656566.2019.1604688DOI Listing

Assessing effectiveness in acne clinical trials: steps towards a core outcome measure set.

Br J Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Schulich School of Medicine and Dentistry, Western University, Windsor, ON, Canada.

Background: Acne ranks second to dermatitis in terms of global burden of skin disease. As such, it is essential that data on treatment efficacy are generated in a way that maximizes the opportunity for comparison among treatments. Interest in developing core outcome sets for use in clinical trials to standardize data collection in skin disease is surging. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18011
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http://dx.doi.org/10.1111/bjd.18011DOI Listing
April 2019
1 Read

Atopic Eczema: Burden of disease and individual suffering - Results from a large EU-Study in adults.

J Eur Acad Dermatol Venereol 2019 Apr 19. Epub 2019 Apr 19.

European Federation of Allergy and Airway Diseases Patient's Associations, Brussels, Belgium.

Background: Atopic eczema (AE, atopic dermatitis) is one the most common non-communicable inflammatory skin diseases affecting 1-5% of the adult population in Europe with marked impairment in quality of life. In spite of great progress in understanding the pathophysiology of disturbed skin barrier and immune deviation, AE still represents a problem in daily clinical practice. Furthermore, the true impact of AE on individual suffering is often not recognized. Read More

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http://dx.doi.org/10.1111/jdv.15634DOI Listing

Efficacy and tolerability of 1% ciclopirox shampoo in the treatment of moderate-to-severe scalp seborrheic dermatitis: a multicenter, prospective, assessor-blinded trial.

G Ital Dermatol Venereol 2019 Jun;154(3):342-346

Difa Cooper, Caronno Pertusella, Varese, Italy -

Background: Seborrheic dermatitis (SD) is a very common inflammatory skin disease. It occurs in 1-3% of the population. The most supported pathogenetic theory links SD to dandruff via a common etiology, yeasts of the genus Malassezia. Read More

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http://dx.doi.org/10.23736/S0392-0488.17.05623-1DOI Listing

Malassezia-derived aryl hydrocarbon receptor ligands enhance the CCL20/ Th17/soluble CD163 pathogenic axis in extra-mammary Paget's disease.

Exp Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Malassezia yeast play a role in the pathogenesis of chronic dermatitis, especially in apocrine areas, by polarizing the local immunologic background to a Th2/Th17 state through aryl hydrocarbon receptor (AhR)-dependent pathways. Extra-mammary Paget's disease (EMPD) is an adenocarcinoma of apocrine origin, and except for cases associated with Malassezia yeast and their metabolites, the lesions typically develop in areas not exposed to environmental material. The purpose of this study was to investigate 1) the immunomodulatory effects of Malassezia metabolites on normal human keratinocytes (NHKCs), focusing on interleukin (IL)-17 and related cytokines/chemokines (IL-23, IL-36γ, CCL20), 2) the expression of these factors in lesion-affected skin in EMPD, and 3) the activation of tumor-associated macrophages (TAMs) by these factors. Read More

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http://dx.doi.org/10.1111/exd.13944DOI Listing

Old is gold? Retrospective evaluation of efficacy and safety of topical psoralen-UVA phototherapy for palmoplantar psoriasis and dermatitis.

Br J Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Photomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

Over the last decade new systemic drugs (e.g. biologics, apremilast, alitretinoin) have diversified the options for treating palmoplantar dermatoses such as psoriasis and dermatitis. Read More

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http://dx.doi.org/10.1111/bjd.18012DOI Listing

Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32-35 weeks.

Eur J Pediatr 2019 Apr 18. Epub 2019 Apr 18.

Paediatric Pneumology Unit, University Clinic Hospital, University of Valencia, Av Blasco Ibáñez, 17, 46010, Valencia, Spain.

Little is known about respiratory morbidity and asthma risk in preterm infants (PTIs) with a gestational age (GA) over 32 weeks. This was a prospective study carried out from birth to 7-8 years, comparing two groups: (a) PTIs (GAs 32 weeks + 1 day to 35 weeks + 0 days, without comorbidities) and (b) full-term infants (FTIs; GA ≥ 37 weeks). Risk and protective factors for bronchiolitis and asthma were identified. Read More

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http://link.springer.com/10.1007/s00431-019-03372-1
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http://dx.doi.org/10.1007/s00431-019-03372-1DOI Listing
April 2019
1 Read

Gluten challenge induces skin and small bowel relapse in long-term gluten-free diet-treated dermatitis herpetiformis.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Tampere University Hospital, Tampere, Finland; Celiac Disease Research Center, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland. Electronic address:

Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease causing an itchy, blistering rash. Skin IgA deposits are pathognomonic for DH, and the treatment of choice is a life-long gluten-free diet (GFD). Preliminary evidence suggests that there are DH patients who redevelop gluten tolerance after adherence to a GFD treatment. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1150DOI Listing

The unwavering doctor who unraveled a medical mystery.

Int J Womens Dermatol 2019 Jun 17;5(2):137-139. Epub 2018 Oct 17.

Department of Dermatology, SUNY Downstate College of Medicine, Brooklyn, New York.

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https://linkinghub.elsevier.com/retrieve/pii/S23526475183004
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http://dx.doi.org/10.1016/j.ijwd.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451741PMC
June 2019
1 Read

A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia.

Clin Case Rep 2019 Apr 20;7(4):695-698. Epub 2019 Feb 20.

2nd Department of Dermatology and Venereology, General Hospital "Papageorgiou", Medical School Aristotle University of Thessaloniki Thessaloniki Greece.

Palisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians' goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time. Read More

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http://dx.doi.org/10.1002/ccr3.2072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452460PMC

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
1 Read

On-farm broiler chicken welfare assessment using transect sampling reflects environmental inputs and production outcomes.

PLoS One 2019 17;14(4):e0214070. Epub 2019 Apr 17.

Department of Animal and Aquacultural Sciences, Faculty of Biosciences, Norwegian University of Life Sciences, Ås, Norway.

To evaluate the utility of transect sampling for assessing animal welfare in large chicken flocks, we quantified relationships between environmental inputs, welfare problems detected using transect sampling, and production outcomes. We hypothesised that environmental inputs including environmental complexity (i.e. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214070PLOS

Putative parapoxvirus-associated foot disease in the endangered huemul deer (Hippocamelus bisulcus) in Bernardo O'Higgins National Park, Chile.

PLoS One 2019 17;14(4):e0213667. Epub 2019 Apr 17.

One Health Institute, School of Veterinary Medicine, University of California, Davis, CA, United States of America.

The huemul (Hippocamelus bisulcus) is an endangered cervid endemic to southern Argentina and Chile. Here we report foot lesions in 24 huemul from Bernardo O'Higgins National Park, Chile, between 2005 and 2010. Affected deer displayed variably severe clinical signs, including lameness and soft tissue swelling of the limbs proximal to the hoof or in the interdigital space, ulceration of the swollen tissues, and some developed severe proliferative tissue changes that caused various types of abnormal wear, entrapment, and/or displacement of the hooves and/or dewclaws. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213667PLOS

Dead Sea Climatotherapy versus topical steroid treatment for Atopic Dermatitis children: long-term follow-up study.

J Dermatolog Treat 2019 Apr 17:1-19. Epub 2019 Apr 17.

c Dead Sea & Arava Science Center , Israel.

The aim of this study was to compare long-term results of 4 weeks Dead Sea Climatotherapy at the Deutsches Medizinisches Zentrum, Israel to those obtained by classical topical treatment for moderate-to-severe Atopic Dermatitis. Seventy-two children from the Czech Republic were divided into three groups of twenty-four and treated during 3 periods (March 2014, October 2014 and March 2015) with gradually increasing sun exposure during 28 consecutive days. Forty-four children were treated with steroid creams at the Department of Dermatovenereology, Third Faculty of Medicine, Charles University and University Hospital of Kralovske Vinohrady, Prague, Czech Republic. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605138DOI Listing

Cardiovascular Disease: Chronic Venous Insufficiency and Varicose Veins.

FP Essent 2019 Apr;479:16-20

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Chronic venous insufficiency (CVI) results from long-term venous hypertension in the legs caused by venous obstruction, venous valve incompetency, muscle pump dysfunction, or a combination of these. CVI occurs in 9.4% of men and 6. Read More

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April 2019
2 Reads

Anaphylaxis after wheat ingestion in a patient with coeliac disease: two kinds of reactions and the same culprit food.

Eur J Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

In recent years, the role of atopic dermatitis epidermal skin barrier defects in inducing a transcutaneous allergic sensitization is highly debated, possibly explaining why some children with eczema are sensitized to foods they have never eaten. In our specific situation, the association between coeliac disease and wheat allergy might be particularly harmful owing to unavoidable strict food avoidance. We describe the case of a young boy affected by coeliac disease who, after an occasional unexpected ingestion of gluten, experienced a complete anaphylactic reaction characterized by urticarial, labial angioedema, wheezing, and hypotension. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001421DOI Listing
April 2019
1 Read

Determining Risk Factors to Develop a Predictive Model of Incontinence-associated Dermatitis Among Critically Ill Patients with Fecal Incontinence: A Prospective, Quantitative Study.

Wound Manag Prev 2019 Apr;65(4):24-33

Tianjin Medical University Hospital Airport Hospital, Tianjin, China.

Critically ill patients with fecal incontinence are at high risk of developing incontinence-associated dermatitis (IAD). Scientific prediction and prevention of IAD are essential.

Purpose: The purpose of this study was to determine the risk factors for IAD among critically ill patients with fecal incontinence. Read More

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A preliminary study of an alternative method for evaluating skin sensitizing potential of chemicals.

Int J Cosmet Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Pavia, Italy.

The skin, being a barrier between the human body and the environment, is exposed to a series of exogenous chemicals and physical factors. Allergic contact dermatitis (ACD) is one of the most common inflammatory skin diseases that occurs in the general population with a prevalence of 20% [1]. The inflammatory condition is induced by a single or multiple exposure to chemical substances, called haptens, which activate the innate immunity (irritative contact dermatitis) or both innate and acquired immunity (allergic contact dermatitis) [2]. Read More

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http://dx.doi.org/10.1111/ics.12530DOI Listing

A job-exposure matrix addressing hand exposure to wet work.

Int Arch Occup Environ Health 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.

Purpose: The aim of this study was to create a job-exposure matrix (JEM) for wet work. A JEM is a tool used to assess exposure to potential health hazards in occupational epidemiological studies. It can be used when counselling concerning job change/job choice, as a medico-legal tool when recognizing diseases as occupational and when planning interventions regarding prevention of, in this case, occupational hand eczema. Read More

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http://link.springer.com/10.1007/s00420-019-01435-2
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http://dx.doi.org/10.1007/s00420-019-01435-2DOI Listing
April 2019
1 Read

A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars.

Clin Ter 2019 Mar-Apr;170(2):e93-e99

Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena - Second Opinion Medical Network, Modena (MO), Italy.

Objective: To investigate the therapeutic effect of CBD-ointment administered on severe skin chronic diseases and/or on their outcome scars.

Methods: A spontaneous, anecdotal, retrospective study of 20 patients with two most frequent skin disorders: psoriasis (n: 5 patients), atopic dermatitis (n: 5) and resulting outcome scars (n: 10). The subjects were instructed to administer topical CBD-enriched ointment to lesioned skin areas twice daily for three months treatment. Read More

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http://dx.doi.org/10.7417/CT.2019.2116DOI Listing
April 2019
1 Read

Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin.

Molecules 2019 Apr 15;24(8). Epub 2019 Apr 15.

Department of Food Science & Technology and Research Institute for Basic Science, Hoseo University, Chungnam 31499, Korea.

Physcion is well known for the treatment of carcinoma. However, the therapeutic effect of physcion on atopic dermatitis (AD) through the inhibition of thymic stromal lymphopoietin (TSLP) level remains largely unknown. In this study, we investigated the anti-AD effect of physcion using HMC-1 cells, splenocytes, and a murine model. Read More

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http://dx.doi.org/10.3390/molecules24081484DOI Listing

Translational drug discovery and development with the use of tissue-relevant biomarkers: towards more physiological relevance and better prediction of clinical efficacy.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Sanofi, Global Head of Immunology Therapeutic Research Area, 640 Memorial Drive, Cambridge, MA, 02139, USA.

Due to the clinical development of drugs such as secukinumab, ustekinumab and dupilumab, major changes have been achieved in the treatment of patients diagnosed with psoriasis and atopic dermatitis. In academia and the pharmaceutical industry, research is increasingly moving towards the development of bi-specific antibodies and multi-specific nanobodies, as there is a compelling need for new treatment modalities for patients suffering from auto-immune or malignant disease. The purpose of this review is to discuss aspects of translational drug development with a particular emphasis on indications such as psoriasis and atopic dermatitis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13942
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http://dx.doi.org/10.1111/exd.13942DOI Listing
April 2019
3 Reads

Phenotypic analysis of atopic dermatitis in children aged 1-12 months: elaboration of novel diagnostic criteria for infants in China and estimation of prevalence.

J Eur Acad Dermatol Venereol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Dermatology, Shanghai Jiaotong University School of Medicine.

Background: Atopic dermatitis (AD) is the most common skin disorder in infancy. However, the diagnosis and definite significance of infantile AD remains a debated issue.

Objective: To analyze the phenotypes of AD in infancy, to establish diagnostic criteria, and to estimate the prevalence of this condition in China. Read More

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http://dx.doi.org/10.1111/jdv.15618DOI Listing
April 2019
1 Read

The role of Langerhans cells in pathologies of the skin.

Immunol Cell Biol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pathology, Dunedin School of Medicine, University of Otago, P O Box 56, Dunedin, New Zealand.

Langerhans cells (LCs) are epidermal immune cells of myeloid origin. Although these cells were primarily thought to play a defensive role in the skin, evidence now indicates a diverse range of LC-mediated effects including relay of viral antigens in herpes simplex infection, recruitment of eosinophils in atopic dermatitis, and promotion of a Th17 response in Candida infection. LCs may have a protective or suppressive function in pathologies of the skin, with differing functions being driven by the skin milieu. Read More

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http://dx.doi.org/10.1111/imcb.12253DOI Listing

Mycosis Fungoides with Spongiosis: a Potential Diagnostic Pitfall.

J Cutan Pathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Mayo Clinic Rochester, Minnesota.

Background: Mycosis fungoides (MF) is characterized by epidermotropic atypical lymphocytes in the absence of spongiosis. However , we describe a unique presentation of MF with spongiosis, mimicking benign inflammatory dermatoses and highlight the importance of pathologic interpretation for diagnostic confirmation.

Methods: A cross-sectional study of consecutive patients diagnosed with MF with spongiosis was conducted. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13477
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http://dx.doi.org/10.1111/cup.13477DOI Listing
April 2019
5 Reads

Direct assessment of skin epithelial barrier by electrical impedance spectroscopy.

Allergy 2019 Apr 16. Epub 2019 Apr 16.

Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.

Background: Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants or microbes to enter the tissue and activate the immune response. The aim of this study was to establish a method to directly assess in vivo the epidermal barrier function by electrical impedance (EI) spectroscopy.

Methods: Mice epidermal barrier was damaged by epicutaneous application of proteases and cholera toxin and by tape stripping. Read More

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http://dx.doi.org/10.1111/all.13824DOI Listing

The role of invariant T cells in inflammation of the skin and airways.

Semin Immunopathol 2019 Apr 15. Epub 2019 Apr 15.

Centre for Cancer Biology, The University of South Australia and SA Pathology, North Terrace, Adelaide, SA, 5000, Australia.

Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells express T cell receptors of very limited diversity. iNKT and MAIT cells recognise antigens presented by the MHC class 1-like monomorphic molecules CD1d and MR1, respectively. Read More

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http://link.springer.com/10.1007/s00281-019-00740-9
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http://dx.doi.org/10.1007/s00281-019-00740-9DOI Listing
April 2019
1 Read

Characterization of Blau syndrome panuveitis with wide-field fluorescein angiography.

Am J Ophthalmol Case Rep 2019 Jun 29;14:92-94. Epub 2019 Mar 29.

Department of Ophthalmology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Purpose: To describe a case of Blau panuveitis, characterized on both portable and tabletop wide-field fluorescein angiography, which resolved on systemic immunosuppression.

Observations: A 5-year-old female presented with bilateral eye pain, redness, and decreased visual acuity due to panuveitis and had a history of arthritis, tenosynovitis, and dermatitis. Similar ocular and systemic findings in the patient's mother and maternal half-brother prompted genetic testing that confirmed the diagnosis of the rare Blau syndrome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183023
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http://dx.doi.org/10.1016/j.ajoc.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447728PMC
June 2019
1 Read

Repeat patch testing in a patient with allergic contact dermatitis improved on dupilumab.

JAAD Case Rep 2019 Apr 3;5(4):336-338. Epub 2019 Apr 3.

Department of Dermatology, Stanford University School of Medicine, Redwood City, California.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126193003
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http://dx.doi.org/10.1016/j.jdcr.2019.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447730PMC
April 2019
6 Reads

Immune and Inflammatory Reponses to Skin Infections.

Curr Dermatol Rep 2018 Dec 22;7(4):338-349. Epub 2018 Sep 22.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Purpose Of Review: There have been recent advances in our understanding of cutaneous immune responses to the important human skin pathogen, (). This review will highlight these insights into innate and adaptive immune mechanisms in host defense and cutaneous inflammation in response to skin infections.

Recent Findings: Antimicrobial peptides, pattern recognition receptors and inflammasome activation function in innate immunity as well as T cells and their effector cytokines play a key role in adaptive immunity against skin infections. Read More

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http://dx.doi.org/10.1007/s13671-018-0235-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461387PMC
December 2018
1 Read

A Pharmacological Review on L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities.

J Pharmacopuncture 2019 Mar 31;22(1):7-15. Epub 2019 Mar 31.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

. (PO) or Purslane is an annual grassy plant that is distributed in many parts of the world, especially the tropical and subtropical areas. PO has some pharmacological properties such as analgesic, antibacterial, skeletal muscle-relaxant, wound-healing, anti- inflammatory and a radical scavenger. Read More

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http://dx.doi.org/10.3831/KPI.2019.22.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461301PMC

The Role of Combination Calcipotriol plus Betamethasone Dipropionate Gel in the Treatment of Moderate-to-Severe Scalp Seborrhoeic Dermatitis.

Authors:
Felix B Yap

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e520-e523. Epub 2019 Mar 28.

Department of Medicine, Faculty of Medicine & Health Sciences, Universiti Tunku Abdul Rahman, Kajang, Selangor, Malaysia.

Objectives: This study aimed to investigate the off-label use of a combination calcipotriol plus betamethasone dipropionate (CBD) gel in the treatment of moderate-to-severe scalp seborrhoeic dermatitis (SSD).

Methods: This retrospective study involved 32 patients with SSD who were prescribed CBD gel at the Subang Jaya Medical Centre, Selangor, Malaysia, between January 2016 and December 2017. The Physician Global Assessment Scale was used to assess disease severity. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443272PMC
November 2018
1 Read

Food Allergen Sensitisation Patterns in Omani Patients with Allergic Manifestations.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e483-e488. Epub 2019 Mar 28.

Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.

Objectives: This study aimed to evaluate the relationship between food allergen sensitisation patterns and allergic manifestations in Omani patients and highlight the importance of specific immunoglobulin E (IgE) testing.

Methods: This retrospective study included all patients referred due to allergic manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, from November 2012 to November 2016. Specific IgE blood testing was performed to determine sensitisation to common foods known to cause allergic reactions. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/299
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http://dx.doi.org/10.18295/squmj.2018.18.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443266PMC
November 2018
1 Read

[Skin Manifestations of Pellagra].

Authors:
Yuuichi Yamamoto

Brain Nerve 2019 Apr;71(4):360-363

Department of Dermatology University of the Ryukyus, Graduate School of Medicine.

Pellagra is a type of dietary deficiency disease caused by an insufficiency of niacin or tryptophan. Symptoms of pellagra include diarrhea, dermatitis, and dementia. It is usually diagnosed based on a patient's dietary history and clinical symptoms. Read More

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http://dx.doi.org/10.11477/mf.1416201276DOI Listing

Testing an ectoin containing emollient for atopic dermatitis.

Curr Pediatr Rev 2019 Apr 15. Epub 2019 Apr 15.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Aim: To describe the methodology in studying patient's acceptability and efficacy of an ectoin containing emollient for atopic dermatitis (AD) Methods: We described the methodology that we used in studying emollients and moisturizers, and patient acceptability of a group of AD patients before and following usage of an ectoin-containing proprietary emollient. These data were also compared with other emollients that we previously reported.

Results: 30 subjects (50% Male, Mean (SD) age: 9. Read More

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http://dx.doi.org/10.2174/1573396315666190415144244DOI Listing
April 2019
1 Read

Apigenin Inhibits IL-31 Cytokine in Human Mast Cell and Mouse Skin Tissues.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Department of Health Management, Jeonju University, Jeonju-si, Jeollabuk-do 55069, Korea.

IL-31 is a recently discovered cytokine that is produced not only in T-cells but also in mast cells. It is strongly implicated to play a key role in inflammatory diseases and in the pathogenesis of itch in atopic dermatitis. Apigenin, a flavonoid of plant origin has numerous biological applications. Read More

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https://www.mdpi.com/1420-3049/24/7/1290
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http://dx.doi.org/10.3390/molecules24071290DOI Listing
April 2019
1 Read

Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies.

J Clin Med 2019 Apr 2;8(4). Epub 2019 Apr 2.

Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.

Atopic dermatitis (AD) is a long-standing inflammatory skin disease that is highly prevalent worldwide. Multiple factors contribute to AD, with genetics as well as the environment affecting disease development. Although AD shows signs of skin barrier defect and immunological deviation, the mechanism underlying AD is not well understood, and AD treatment is often very difficult. Read More

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http://dx.doi.org/10.3390/jcm8040444DOI Listing

Fat Grafting for Improved Ileostomy Ostomy Device Fit: A Case Report.

Wound Manag Prev 2019 Mar;65(3):38-44

University of Pittsburgh Medical Center, Pittsburgh, PA.

For patients with an ostomy, a poor fitting appliance may cause leakage, peristomal dermatitis, and frequent appliance changes.

Purpose: The purpose of this case study was to report the outcome of fat grafting to augment peristomal soft tissue and improve appliance fit.

Case Study: A 57-year-old woman with a history of Crohn's disease presented with soft-tissue deficiency and uneven contour around her ileostomy site. Read More

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March 2019
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Effectiveness, safety, and economic evaluation of topical application of a herbal ointment, Jaungo, for radiation dermatitis after breast conserving surgery in patients with breast cancer (GREEN study): Study protocol for a randomized controlled trial.

Medicine (Baltimore) 2019 Apr;98(15):e15174

Associate Professor, Department of Korean Obstetrics and Gynecology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea.

Introduction: This is a prospective, open-label, parallel-group, randomized controlled trial that evaluates the effectiveness and safety of adjuvant application of Jaungo (JUG) for radiation-induced dermatitis (RD) in breast cancer patients undergoing radiation therapy, in comparison with general supportive care (GSC).

Methods/design: Eighty female patients, who have been diagnosed with unilateral breast cancer, will be allocated to either the JUG or GSC group with an allocation ratio of 1:1 after breast conservation surgery, in the Kyung Hee University Korean Medicine Hospital, Seoul, Republic of Korea. Both the groups will be subjected to GSC, but only the JUG group participants will apply adjuvant JUG ointment on the irradiated skin for 6 weeks, twice a day. Read More

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http://dx.doi.org/10.1097/MD.0000000000015174DOI Listing
April 2019
2 Reads

Is there agreement between evaluators that used two scoring systems to measure acute radiation dermatitis?

Medicine (Baltimore) 2019 Apr;98(15):e14917

Graduate Program in Health Sciences, Medicine School, Federal University of Uberlandia, Uberlandia, Minas Gerais.

To analyze the agreement between the nurses evaluating radiodermatitis that used the Radiation Therapy Oncology Group (RTOG) and the World Health Organization (WHO) scales.A prospective and longitudinal study conducted in 2016 to 2017, in a university hospital. We analyzed 855 images of irradiated sites of 100 breast cancer women during radiotherapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000014917DOI Listing
April 2019
4 Reads

Incidence, Risk Factors and Outcomes Among Children With Acute Flaccid Myelitis: A Population-based Cohort Study in a California Health Network Between 2011 and 2016.

Pediatr Infect Dis J 2019 Apr 10. Epub 2019 Apr 10.

Department of Pediatric Infectious Diseases, Kaiser Permanente Oakland Medical Center, Oakland, California.

Background: Acute flaccid myelitis (AFM) is defined as an acute onset of limb weakness with longitudinal spinal gray matter lesions. Reporting bias and misdiagnosis confound epidemiologic studies of AFM. We mitigated these confounders by using a large data set to assess AFM incidence, risk factors and outcomes in a fixed population. Read More

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http://dx.doi.org/10.1097/INF.0000000000002276DOI Listing

Hyponatremia secondary to severe atopic dermatitis in early infancy.

Pediatr Int 2019 Apr 15. Epub 2019 Apr 15.

Department of Allergy, Kanagawa Children's Medical Center, Yokohama, Japan.

Background: Infants with atopic dermatitis who developed hyponatremia and hyperkalemia with raised aldosterone level have been repeatedly described in Japanese domestic literatures. However, similar reports from other countries are scarce.

Methods: Including our experiences, we collected reports of atopic dermatitis complicated with hyponatremia (≤130 mEq/L), written either in English or in Japanese, to delineate the characteristics and to elucidate the pathophysiology of this condition. Read More

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http://dx.doi.org/10.1111/ped.13865DOI Listing
April 2019
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Dietary habits in adult Japanese patients with atopic dermatitis.

J Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.

Dietary habits can modulate the pathogenesis of atopic dermatitis. We evaluated these habits in adult Japanese patients with atopic dermatitis using a validated, brief-type self-administered diet history questionnaire and compared the results to those of age- and sex-matched healthy controls. Patients with atopic dermatitis showed higher intakes of carbohydrate and potatoes and lower intakes of alcohol, niacin, meat and oils/fats compared with those of the healthy controls. Read More

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http://dx.doi.org/10.1111/1346-8138.14881DOI Listing
April 2019
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Sympathetic dysfunction dermatitis in a revascularised upper extremity after near-total amputation - A case report and review of literature.

Indian J Plast Surg 2018 Sep-Dec;51(3):327-330

Consultant Plastic surgeon, Sparsh Clinics, Nagpur, Maharashtra, India.

Commonly reported complications after revascularisation or replantation of extremity are vascular thrombosis leading to complete or partial failure, bony non-union or malunion, joint stiffness and incomplete or abnormal sensory recovery. Sympathetic dysfunction dermatitis is an unreported complication after revascularisation or replantation surgery which results due to denervation of the extremity. We report a case of a young adult who developed eczematous dermatitis over the revascularised upper limb and discuss the role of sympathetic dysfunction in the development of these skin lesions. Read More

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http://dx.doi.org/10.4103/ijps.IJPS_135_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440340PMC

Patch Testing in Allergic Contact Dermatitis over the Lower Extremities.

Indian J Dermatol 2019 Mar-Apr;64(2):164

Department of Dermatology, Venereology and Leprology, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka, India.

Background: There is an increased incidence of allergic contact dermatitis (ACD) over the lower extremities due to over-the-counter topical preparations, occupational risk, and usage of several chemicals in the manufacture of designer footwear.

Aims And Objectives: The aim of the study was to identify the common allergens and polysensitization pattern involved in ACD over the lower extremities.

Materials And Methods: It is a cross-sectional study, wherein a total of 80 patients were recruited over a period of 18 months. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/164/254171
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http://dx.doi.org/10.4103/ijd.IJD_759_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440194PMC
April 2019
2 Reads

Acetylation Phenotype Variation in Patients with Allergic Contact Dermatitis.

Indian J Dermatol 2019 Mar-Apr;64(2):164

Department of Dermatology, Al-Kadhimiya Teaching Hospital, Baghdad, Iraq.

Background: Studies have been done on acetylation phenotype in different diseases but not with allergic contact dermatitis (ACD).

Patients And Methods: Thirty-five ACD patients and 67 healthy volunteers were enrolled in the study. After an overnight fast, each participant received a single oral dose of 100 mg of dapsone. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/164/254166
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http://dx.doi.org/10.4103/ijd.IJD_58_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440188PMC
April 2019
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Summer-Associated Dermatitis: A Cross-Sectional Study of a Unique Eczematous Dermatosis in South India.

Indian J Dermatol 2019 Mar-Apr;64(2):136-142

Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.

Background: In our hospital setup located in the tropical zone, during each summer, we frequently come across a unique eczematous dermatosis among elderly females that typically occur in summer.

Aims And Objectives: We carried out this study with the objective of studying the demographic and clinical features of this dermatosis.

Materials And Methods: In this hospital-based descriptive study, we enrolled twenty consecutive patients presenting with typical features of the dermatosis of interest, such as itchy eczematous scaly papule and plaques distributed predominantly over flexures, self-limiting in nature, and with summer exacerbation. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/136/254169
Publisher Site
http://dx.doi.org/10.4103/ijd.IJD_668_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440175PMC
April 2019
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Mucocutaneous Adverse Reactions of Cancer Chemotherapy and Chemoradiation.

Indian J Dermatol 2019 Mar-Apr;64(2):122-128

Department of Dermatology, Global Health City, Chennai, Tamil Nadu, India.

Background: With the introduction of newer anti-cancer agents, the adverse effects have become more rampant which call for concern in the treatment of patients with cancer. Hence, the assessment and management of dermatological adverse effects of anti-cancer therapy have become a significant part of the care of patients with cancer and require proper and close collaboration between the dermatologists and the oncologists.

Aims: To assess the frequency and pattern of mucocutaneous adverse reactions to cancer chemotherapy and chemoradiation and grade them according to their severity and to identify hematological and biochemical changes related to cancer chemotherapy-induced mucocutaneous adverse reactions. Read More

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http://dx.doi.org/10.4103/ijd.IJD_129_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440193PMC

Biophysical Measurements and Ultrasonographic Findings in Chronic Dermatitis in Comparison with Uninvolved Skin.

Indian J Dermatol 2019 Mar-Apr;64(2):90-96

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nowadays noninvasive techniques are performed to evaluate the biophysical properties of skin .

Aims: The aim of this study was to evaluate the biophysical and ultrasonographic properties of skin in chronic contact or atopic dermatitis to provide better insight into pathogenesis, diagnosis, and treatment response.

Materials And Methods: The stratum corneum hydration, transepidermal water loss (TEWL), pH, erythema, melanin, sebum, friction, temperature, elasticity parameters (R0, R2, and R5), the thickness and echo-density of epidermis, dermis, and subepidermal low-echogenic band (SLEB) were measured on lesional, perilesional, and symmetrical skin of 22 chronic dermatitis patients. Read More

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http://dx.doi.org/10.4103/ijd.IJD_464_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440184PMC
April 2019
3 Reads