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Imaging Sci Dent 2020 Jun 18;50(2):175-180. Epub 2020 Jun 18.

Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Purpose: In this study, we used ultrasonography to monitor the use of hyaluronic acid (HA) as a filler in the face for esthetic reasons. We monitored changes in the filler shape, distribution, and relationship with adjacent anatomical structures over a 180-day period.

Materials And Methods: Two patients each received an ultrasound-guided injection of HA, with different products and application sites for each patient. Read More

Biomed Res Int 2020 21;2020:8676343. Epub 2020 May 21.

Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", Via Gino Marinuzzi, 3-90129 Palermo (PA), Italy.

Objective: Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in patients following the injection. Read More

Clin Cosmet Investig Dermatol 2020 18;13:371-378. Epub 2020 May 18.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background And Objectives: There is a wide diversity of opinions regarding the management of delayed inflammatory reactions (DIRs) secondary to hyaluronic acid (HA)-based fillers. The plethora of approaches has led the authors to conduct a review regarding management and treatment of DIRs as well as establish therapeutic guidelines for this purpose.

Materials And Methods: A review of the literature was performed through databases such as PubMed using keywords including HA-fillers and complications, delayed HA filler sequelae and therapy, soft tissue and dermal filler reactions and management. Read More

Medicine (Baltimore) 2020 Jun;99(24):e20394

Department of Plastic surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.

Introduction: Hyaluronic acid injections is relatively safe with little risk of complications. Although herpes reactivation after the injection of hyaluronic acid is rare, it produces quite a huge pressure and panic on patients. Quite a lot cosmetic practitioners have no awareness of preventing, diagnosing, and giving correct treatment in time due to lack of experience. Read More

Int J Dermatol 2020 Jun 9. Epub 2020 Jun 9.

Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

J Cosmet Dermatol 2020 Jun 5. Epub 2020 Jun 5.

All Saints Clinic, Double Bay, NSW, Australia.

Background: Tissue fillers are generally safe and well tolerated by patients. However, complications do occur and may be very severe, such as intravascular injection (with occasional residual tissue loss, visual and neurological sequelae) and late nodularity and swelling. Methods to lessen the likelihood of complications have been the subject of much recent literature. Read More

J Cosmet Dermatol 2020 Jun 2. Epub 2020 Jun 2.

Behavior, Paris, France.

Background: Aging signs can be corrected through volume restoration in multiple soft tissue layers and in the supraperiosteal plane using hyaluronic acid (HA) or nonhyaluronic acid (non-HA) fillers. The non-HA bioresorbable polycaprolactone (PCL)-based filler with collagen-stimulating properties has a proven safety profile, but rare potential complications such as nodules and granuloma can occur. Furthermore, PCL-based fillers cannot be immediately removed by injection of an enzyme. Read More

Aesthetic Plast Surg 2020 May 22. Epub 2020 May 22.

MD Codes Institute, Rua Santa Justina, 660 - cjs 121 e 124, Via Olímpia, Sao Paulo, SP, Brazil.

Background: Patients often seek aesthetic correction of facial deficiencies (e.g., lines and folds) that are rarely the underlying cause of dissatisfaction with their appearance. Read More

Plast Reconstr Surg Glob Open 2020 Apr 29;8(4):e2753. Epub 2020 Apr 29.

Academic Aesthetics Mastermind Group, Trikwan Aesthetics, London, UK.

Background: Tear trough (TT) treatment with hyaluronic acid soft tissue fillers is an increasingly popular aesthetic procedure. The traditional needle technique is cited many times in the literature with no studies looking at the results, complications and satisfaction rate with the use of the cannula device instead. The aims of this study are to describe the experience of 4 aesthetic doctors in the treatment of TT deformity and assess complications and side effects, overall satisfaction and improvement. Read More

Clin Cosmet Investig Dermatol 2020 7;13:345-349. Epub 2020 May 7.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Over the past few decades, soft tissue augmentation is ever-increasing, specifically hyaluronic acid (HA)-based filler injections. As the number of these procedures have risen, so have the adverse reactions. Delayed-type inflammatory reactions (DIRs) secondary to tissue fillers are typically classified according to the time of appearance post-procedure and have various presentations including nodules, abscesses, edema, and discoloration. Read More

Clin Cosmet Investig Dermatol 2020 5;13:333-344. Epub 2020 May 5.

Dr Zenker Dermatology, Munich, Germany.

Background: Combinations of minimally invasive procedures (MIPs) are often used in aesthetic treatments and are increasingly considered as the new standard of care. Three agents with specific properties are available in this perspective: a polycaprolactone (PCL)-based collagen stimulator, a poly-L-lactic acid (PLLA)- and a poly-glycolic acid (PLGA)-based resorbable suspension suture with a 3D-cone technology, and a cross-linked hyaluronic acid (HA).

Objective: To develop the first practice guidelines on rejuvenation treatment of the face and the neck using combinations of these agents, whether associated or not with other widely used MIPs such as botulinum neurotoxins or energy-based devices. Read More

J Biol Regul Homeost Agents 2019 Nov-Dec;33(6 Suppl. 2):103-108

Master course in Aesthetic Medicine, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Italy.

Several approaches have been proposed for soft tissue augmentation using injectable materials for lip and soft-tissue augmentation due to their physical and biological properties. Hyaluronic acid represents a natural component of the connective tissues, related to wound healing and skin regeneration. The aim of this research was to investigate the clinical and histological effectiveness of cross-linked hyaluronic acid for lip augmentation. Read More

J Cosmet Dermatol 2020 May 15. Epub 2020 May 15.

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States.

Background: The use of injectable soft tissue fillers has become an essential tool in aesthetic rejuvenation. Rheology, the study of flow of matter, helps to understand the function of these products.

Objective: The purpose of this article is to review the rheologic properties of soft tissue fillers currently available in the United States and to evaluate how these properties relate to clinical performance. Read More

J Drugs Dermatol 2020 Jan;19(1):100-103

Millennials, defined as the generation of individuals born between 1981 and 1996, have emerged as one of the leading patient demographics seeking minimally invasive cosmetic procedures. Worldwide, millennials are more likely to consider preventative treatments compared to any other age-group. The three most popular minimally invasive facial procedures in this demographic include botulinum toxin, dermal fillers (eg, hyaluronic acid, calcium hydroxylapatite, facial fat-fillers), and microdermabrasion. Read More

Dermatol Ther 2020 May 8:e13539. Epub 2020 May 8.

Department of Plastic Surgery, Amsterdam University Medical Center, Amsterdam, Netherlands.

The use of hyaluronic acid (HA) gel fillers for rejuvenation of the face has been increasing in popularity over the years. This nonsurgical, temporary technique is commonly used in the periocular region to restore volume. The aim of this study was creating awareness in the potential causes of edema after hyaluronic acid gel filler injections under the eyes. Read More

Ophthalmic Plast Reconstr Surg 2020 May/Jun;36(3):239-240

Aesthetic Oculoplastic Surgery, Boca Raton, Florida, U.S.A.

Ann Transl Med 2020 Mar;8(6):362

ORL Department, Ludwig-Maximilians University Munich, Munich, Germany.

Background: The search for effectiveness and safety in the use of dermal fillers, is an ongoing challenge for aesthetic physicians, plastic surgeons and the science of bioengineering. Understanding the variety of characteristics, capabilities, advantages and disadvantages of available injectables is essential to reduce complication rates and achieve satisfying aesthetic and functional results.

Methods: Algeness is a 100% natural, biodegradable tissue implant, consisting of a gel derived from agarose. Read More

Lasers Surg Med 2020 Apr 29. Epub 2020 Apr 29.

CNP Skin Clinic, Cheonan, 147, Gosokcheol-daero, Asan, Chungcheongnam-do, 31470, Republic of Korea.

Background And Objectives: Combined sequential treatments with multiple modalities such as lasers and soft-tissue fillers are commonly required for the treatment of atrophic acne scars. Recently, fractional treatment with picosecond-domain lasers has proven to be effective for skin rejuvenation and scar treatment. However, little is known about the effects of picosecond-domain fractional laser treatment over hyaluronic acid fillers (HAFs). Read More

J Eur Acad Dermatol Venereol 2020 Apr 28. Epub 2020 Apr 28.

Dermatology Department, Hospital Clínic, University of Barcelona, Barcelona, Spain.

J Cosmet Dermatol 2020 Apr 25. Epub 2020 Apr 25.

CROMA-PHARMA GmbH, Leobendorf, Austria.

Background: Soft tissue fillers are typically used for rejuvenating an aging face; they are also employed in the treatment of certain pathologic conditions, including facial lipoatrophy, morphological asymmetry, and debilitating scars.

Aims: The aim of this clinical study was to evaluate the effectiveness and safety of Princess® Volume (PV) in patients with facial lipoatrophy (FLA), morphological asymmetry (MA), or debilitating scars (DS).

Patients/methods: This prospective, noncomparative, multicenter clinical study consisted of five visits spread across 36 weeks. Read More

J Cosmet Dermatol 2020 Apr 21. Epub 2020 Apr 21.

Skin Laser and Surgery Specialists of New York and New Jersey, New York, NY, USA.

Background: Dermal fillers have been used safely and effectively to revolumize aging hands. We assess the effectiveness of polymethylmethacrylate (PMMA) to treat the volume loss of photoaged dorsal hands for up to 12 months.

Methods: In a 12-month prospective study, 15 subjects were treated with PMMA filler in the bilateral dorsal hands. Read More

Dermatol Ther 2020 May 7;33(3):e13424. Epub 2020 May 7.

Department of Plastic Surgery, Fortis Hospital, Mohali, Punjab, India.

As most Asian women desire to have an "inverted triangle" appearance for face, there is an increasing trend to give a large volume bolus (LVB) injection in the submental region of the chin for its lengthening. Hyaluronic acid (HA) dermal fillers are very popular for facial contouring and reshaping, including the chin area. Filler injection in the submental area has been a popular method to lengthen the chin. Read More

J Cosmet Dermatol 2020 Jun 12;19(6):1301-1306. Epub 2020 Apr 12.

Dermatology and Venereology, Nazilli State Hospital, Aydın, Turkey.

Background: A chin that is of right size, shape, and contour plays a crucial role in overall facial balance and esthetically harmonious appearance. Dermal fillers have been widely used for correcting mild to moderate chin retrusion and resorption.

Aims: The aim of this study was to share our preferential technique for chin augmentation and to evaluate our results in 50 patients. Read More

Arch Dermatol Res 2020 Apr 11. Epub 2020 Apr 11.

Department of Dermatology, Northwestern University, 676 N St Clair St, Suite 1600, Chicago, IL, 60611, USA.

J Drugs Dermatol 2020 Apr;19(4):405-411

Background/Objectives: Treatment options for the correction of age-related changes in skin include the use of energy-based devices and dermal fillers. In this study, we evaluate the clinical efficacy and tolerability of microfocused ultrasound with visualization (MFU-V) and injectable calcium hydroxylapatite (CaHA) filler diluted with normal saline, for the correction of age-related changes and to assess patients' satisfaction with this combination therapy. Methods: This was a randomized, split-face, comparative clinical study and immunohistochemical analysis in 20 subjects with indications for lower face, neck and décolleté lifting. Read More

J Dermatolog Treat 2020 Apr 6:1-7. Epub 2020 Apr 6.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Filler injection has become an extremely popular method for facial skin rejuvenation, including the periorbital area. In the recent years, new polynucleotide (PN)-containing filler products have been used for esthetic purposes. We aimed to investigate the efficacy and safety of PN filler injection in the periorbital area. Read More

Plast Reconstr Surg 2020 04;145(4):965-966

São Paulo, Brazil From the Laboratory of Microscopy and Plastic Surgery, University of São Paulo.

Dermatol Surg 2020 Mar 24. Epub 2020 Mar 24.

Private Practice, California Dermatology & Clinical Research Institute, Encinitas, California.

Background: A range of monophasic dermal fillers made of high-molecular-weight hyaluronic acid (HA) chains with reduced cross-linking was developed for aesthetic procedures.

Objective: The efficacy, durability, and safety of 2 of these resilient HA (RHA) fillers, and their noninferiority to an effective HA comparator available in the United States, were tested in the treatment of dynamic facial wrinkles.

Methods: A 15-month, prospective, multicenter, active-controlled, randomized, double-blinded, split-face clinical trial was carried out on 174 subjects presenting moderate-to-severe bilateral nasolabial folds (NLFs). Read More

Curr Mol Med 2020 Mar 25. Epub 2020 Mar 25.

Department of Applied Cell Sciences, Tabriz university of medical sciences. Iran.

Stroke is known as one of very important public health problems which are related to a societal burden and tremendous economic. It has been showed, there are few therapeutic approaches in the treatment of this disease. In this regard, present therapeutic platforms aim to obtain neuroprotection, reperfusion, and neurorecovery. Read More

Aesthetic Plast Surg 2020 Mar 23. Epub 2020 Mar 23.

Department of Plastic Surgery of Peking Union Medical College Hospital Of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Objective: Botulinum toxin injection, micro-needling injection, and filler injection are the most widely used non-surgical facial cosmetic treatments. Hypersensitivity reactions associated with injections have not received sufficient attention due to their low incidence rates. The authors tried to summarize the characteristics of the hypersensitivity caused by cosmetic injections and helped to improve the diagnosis and treatment. Read More

Australas J Dermatol 2020 Mar 22. Epub 2020 Mar 22.

Skin Institute, Remuera, Auckland, New Zealand.

Facial aesthetic treatment with injectable neuromodulators and hyaluronic acid fillers is well established, with favourable safety profiles and consistent outcomes. As with any medical treatment, adverse events and complications may occur. Adverse events associated with these products are typically transient and mild to moderate in severity. Read More

Sci Rep 2020 Mar 20;10(1):5127. Epub 2020 Mar 20.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

HA (Hyaluronic acid) filler, the most commonly used dermal filler, causes several side effects. HA-PN (Hyaluronic acid-Polynucleotide), a new composite filler, has excellent biocompatibility and induces tissue regeneration. In this study, we compare the efficacies and safety profiles of these fillers. Read More

J Cosmet Dermatol 2020 Mar 17. Epub 2020 Mar 17.

Falck Clinic, Aesthetic Medicine Centre, Amsterdam, The Netherlands.

Background: Inadvertent intra-arterial injection of dermal fillers including calcium hydroxylapatite (CaHA) can result in serious adverse events including soft tissue necrosis, permanent scarring, visual impairment, and blindness. When intra-arterial injection occurs, immediate action is required for optimal outcomes, but the infrequency of this event means that many physicians may never have experienced this scenario. The aim of this document is to provide evidence-based and expert opinion recommendations for the recognition and management of vascular compromise following inadvertent injection of CaHA. Read More

Prog Retin Eye Res 2020 Mar 10:100848. Epub 2020 Mar 10.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

Iatrogenic ophthalmic artery occlusion (IOAO) is a rare but devastating ophthalmic disease that may cause sudden and permanent visual loss. Understanding the possible etiologic modalities and pathogenic mechanisms of IOAO may prevent its occurrence. There are numerous medical etiologies of IOAO, including cosmetic facial filler injection, intravascular procedures, intravitreal gas or drug injection, retrobulbar anesthesia, intraarterial chemotherapy in retinoblastoma. Read More

Clin Cosmet Investig Dermatol 2020 20;13:31-48. Epub 2020 Jan 20.

Centro Medico Galeno, Milano 20122, Italy.

Compared to other domains, tissue engineering and esthetics have dramatically expanded in recent years, leading to both major biomedical advances and futuristic perspectives. The two share a common approach based on biomaterials, especially polymers. This paper illustrates this with the example of polycaprolactone (PCL), a polymer synthesized in the early 1930s, and one of its most recent applications, a PCL-based collagen stimulator, a filler used in esthetics. Read More

Stem Cells Int 2020 14;2020:1823427. Epub 2020 Feb 14.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Millions of plastic surgeries are performed worldwide every year with the objective of correcting lipodystrophies stemming from lesions, tumor resections, birth defects, and AIDS-associated antiretroviral therapy. Besides that, a large number of clinical research have assessed the outcome of procedures that rely on combinations of dermal fillers and autologous cells. However, little is known about the safety of these combinations and the localization of the injected cells. Read More

Dent Clin North Am 2020 04 17;64(2):325-339. Epub 2020 Jan 17.

Department of Oral & Maxillofacial Surgery, Woodhull Medical Center, 760 Broadway, Brooklyn, NY 11206, USA.

For the general dentist, the use of BTA and dermal fillers confers the ability to exert control over the soft tissues surrounding the mouth to better create a harmonious smile. The injection of BTA and fillers into the facial musculature and dermis requires a level of finesse to achieve the desired outcomes. A sound understanding of the mechanisms of action and the ability to manage potential complications are also necessary, because the dentist administering BTA and dermal fillers must be competent to the same level as other providers who have traditionally been the gatekeepers of such agents. Read More

Aesthet Surg J 2020 04;40(5):NP322-NP323

Department of Dermatology, University of British Columbia, Vancouver, BC, Canada.

Aesthet Surg J 2020 Feb 28. Epub 2020 Feb 28.

Department of Plastic Surgery and Hand Surgery, Technical University of Munich, Munich, Germany.

Background: Hyaluronic acid-based tissue fillers are commonly used in reconstructive surgery as well as for aesthetic augmentation. A new type of recombinant silk-based tissue fillers might pose a beneficial alternative for surgeons and patients.

Objectives: The aim of this study was to compare injectability, reshaping, tolerability, and post-implantation behavior of dermal filler preparations containing recombinant silk hydrogel with a commercially available hyaluronic acid filler in two different animal models. Read More

Aesthet Surg J 2020 04;40(5):NP320-NP321

J Cosmet Dermatol 2020 Feb 28. Epub 2020 Feb 28.

Department of Dermatology and Allergy, Ludwig-Maximilian-University, Munich, Germany.

Background: Filling materials have increasingly been used in aesthetics over the last decades. Understanding the pathophysiology of granuloma formation as a very relevant unwanted side effect of filler application may be essential to help avoid these adverse events.

Aims: Our aim was to investigate the role of the inflammasome in the formation of filler granuloma, as a central column of the innate immune response. Read More

Plast Reconstr Surg 2020 03;145(3):659e-661e

Yonsei E1 Plastic Surgery Clinic, Anyang, Republic of Korea Department of Plastic and Reconstructive Surgery, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, Republic of Korea.

Plast Reconstr Surg 2020 03;145(3):658e-660e

Division of Oculofacial Plastic Surgery, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Plast Reconstr Surg 2020 03;145(3):652e-653e

Division of Anatomy, Department of Medical Education, Albany Medical College, Albany, N.Y. Division of Anatomy, Department of Medical Education, Albany Medical College, Division of Plastic Surgery, Department of Surgery, Albany Medical Center, Albany, N.Y.

Plast Reconstr Surg 2020 03;145(3):661-667

London and Birmingham, United Kingdom From Queen Elizabeth Hospital.

Background: Nonsurgical rhinoplasty with injectable dermal fillers has become an increasingly popular alternative to surgical procedures, in view of its relative low cost, convenience and rapid recovery, and low risk profile. The safety and efficacy of nonsurgical rhinoplasty remains a relatively contentious and ambiguous matter, given that there are few large-scale series reporting results or complications. This study reports the experience of a single clinician performing nonsurgical rhinoplasty in the largest cohort to date. Read More

Clin Cosmet Investig Dermatol 2020 28;13:87-97. Epub 2020 Jan 28.

Private Practice, Milan, Italy.

Introduction: Hyaluronic Acid (HA) fillers are among the most used products in cosmetic medicine. Companies offer different formulations to allow full facial treatment and/or remodeling. Gels are being studied to establish the biophysical properties behind the specific clinical use and a correlation between the gel biophysical properties and their clinical performance. Read More

Eye (Lond) 2020 Feb 17. Epub 2020 Feb 17.

Perfect Eyes Ltd, 121, Harley Street, London, W1G 6AX, UK.

Background: Visual loss from aesthetic hyaluronic acid filler injections is an under-reported complication. Our study surveyed British Oculoplastic consultants and Consultant members of the British Eye Emergency Care Society, on their awareness of visual vascular complications of dermal fillers and its emergency management.

Methods: A prospective survey of the members of the British Oculoplastic Society and the British Eye Emergency Society, using the Survey Monkey platform. Read More

Aesthetic Plast Surg 2020 Jun 10;44(3):1058-1065. Epub 2020 Feb 10.

Department of Otolaryngology, Tulane University Medical Center, 1430 Tulane Ave, #8659, New Orleans, LA, 70112, USA.

Background: Medical tourism for cosmetic surgery has become increasingly popular in recent years. The existing literature has identified poor outcomes associated with general cosmetic tourism; however, the complications associated with cosmetic tourism for facial rejuvenation remain poorly understood. The aims of this study are to delineate the risk profile associated with medical tourism for facial rejuvenation. Read More

J Clin Aesthet Dermatol 2019 Dec 1;12(12):13-16. Epub 2019 Dec 1.

Drs. El Hoshy, Abdel-Halim, El-Nabarawy, and Shalaby are with the Dermatology Department at Cairo University in Cairo, Egypt.

A 77-year-old female patient presented with bilateral tender, swollen, erythematous, focally crusted cheeks with a discharge of pus and necrotic material, which had developed one month after autologous fat transfer and a corrective injection procedure conducted to correct an overdone fat transfer. Histopathological examination of the discharged material using routine hematoxylin and eosin staining revealed degenerated collagen admixed with three different filler materials. Scattered all throughout the specimen were numerous thick-walled, basophilic, nonbudding spherical bodies of variable sizes. Read More