J Cosmet Laser Ther 2017 Jul 28. Epub 2017 Jul 28.

b Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea.

Background: Hydrolifting is a newly developed modality of skin rejuvenation which enhances overall facial volume augmentation and recovers skin thickness through multi-pass HA injection. Although it is commonly performed, only a few articles have reported on the rejuvenating effects of hydrolifting. Moreover, clear protocols and possible mechanisms of the procedure have not been elucidated. Read More

J Craniofac Surg 2017 Jul 26. Epub 2017 Jul 26.

Department of Plastic Surgery and Reconstructive Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.

Introduction: Cosmetic injections of dermal fillers or fat could cause ophthalmic artery embolism and even blindness, the high-risk regions of which are considered glabellar, nasal dorsum, and nasolabial fold. Understanding anatomy of the related arteries is important for a physician to safely perform filler injections. To investigate the mechanisms of ophthalmic artery embolism following the injections, cadaver anatomy was studied. Read More

J Dermatolog Treat 2017 Aug 9:1-6. Epub 2017 Aug 9.

b Department of Dermatologic Surgery and Laser Unit, St. Thomas' Hospital , St. John's Institute of Dermatology , London , UK.

Background: Biofilms are diverse groups of microorganisms encased in a self-produced matrix that offers protection against unfavorable conditions and antibiotics.

Methods: We performed a literature search using the MEDLINE electronic database. Only original articles published in English were considered for review. Read More

Mol Med Rep 2017 Jul 21. Epub 2017 Jul 21.

Department of Pathophysiology, China Medical University, Heping, Shenyang, Liaoning 110001, P.R. China.

Minimally invasive aesthetic and cosmetic procedures have increased in popularity. Injectable dermal fillers provide soft tissue augmentation, improve facial rejuvenation and wrinkles, and correct tissue defects. To investigate the use of adipose‑derived stem cells integrated with a hyaluronic acid based gel as a dermal filler, the present study used cytotoxicity studies, proliferation studies, adipogenic and osteogenic differentiation, apoptosis assays and scanning electron microscopy. Read More

Arch Plast Surg 2017 Jul 15;44(4):340-343. Epub 2017 Jul 15.

Department of Plastic and Reconstructive Surgery, Busan Baik Hospital, InJe University School of Medicine, Busan, Korea.

Performing rhinoplasty using filler injections, which improve facial wrinkles or soft tissues, is relatively inexpensive. However, intravascular filler injections can cause severe complications, such as skin necrosis and visual loss. We describe a case of blepharoptosis and skin necrosis caused by augmentation rhinoplasty and we discuss the patient's clinical progress. Read More

Clin Cosmet Investig Dermatol 2017 29;10:239-247. Epub 2017 Jun 29.

Prager & Partner Dermatologische Praxis, Hamburg, Germany.

Background: Enhancement of the midface can be achieved with volumizing hyaluronic acid (HA) fillers.

Objective: The objective of this study was to compare the safety and effectiveness of Cohesive Polydensified Matrix(®) 26 mg/mL HA gel (CPM-26) and Vycross(®) 20 mg/ml HA gel (VYC-20) in a controlled, randomized, evaluator-blind, split-face clinical study.

Patients And Methods: Subjects with moderate-to-severe malar volume loss on the Merz Aesthetics Scale (MAS) received CPM-26 on one side and VYC-20 on the contralateral side of the face. Read More

J Cosmet Dermatol 2017 Jul 17. Epub 2017 Jul 17.

Faculdade de Odontologia, Departamento de Clínica, Patologia e Cirurgia Odontológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

The use of cosmetic fillers agents in orofacial region has become more often used for esthetic concern. Although adverse effects are rare, some patients may develop foreign body reaction to such fillers. Hyaluronic acid (HA) is a biomaterial in the spotlight, because it is normally present in several tissues of human body. Read More

J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):241-246

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

To correct skin imperfections, aesthetic medicine today makes use of injectable dermal fillers that allow filling skin by increasing the volume of soft tissue. Currently, there are many fillers usable for their excellent biocompatibility and low allergic reactions that ensure good results and good compliance. Among these, the most widely used filler is Human Plasma, obtained by centrifugation from patient blood and processed through cycles of centrifugation and heating, until it becomes a gel. Read More

J Craniofac Surg 2017 Jul;28(5):e481-e482

*Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National, University †Research Institute of Clinical Medicine-Biomedical Research Institute of Chonbuk National, University Hospital, Jeonju, Republic of Korea.

In recent years, fillers have been widely used for soft tissue augmentation. Although they are generally considered to be safe, many complications have been reported to date. Nose and nasolabial fold augmentations with fillers can lead to an implementation of nasal skin necrosis, possibly caused by intravascular embolism and/or extravascular compression. Read More

Clin Cosmet Investig Dermatol 2017 14;10:229-238. Epub 2017 Jun 14.

Medical Affairs, Galderma Laboratories, L.P., Fort Worth, TX, USA.

Introduction: The appeal of hyaluronic acid fillers for facial soft tissue augmentation is attributable to both an immediate aesthetic effect and relatively short recovery time. Although recovery time is an important posttreatment variable, as it impacts comfort with appearance and perceived treatment benefit, it is not routinely evaluated. Natural-looking aesthetic outcomes are also a primary concern for many patients. Read More

Dermatol Surg 2017 Jun 6. Epub 2017 Jun 6.

*Clinique REMUSAT, Paris, France;†Private Practice, Paris, France;‡Private Practice, Paris, France;§Private Practice, Paris, France;¶Fondation Rothschild, Paris, France;‖Private Practice, Paris, France;**GREDECO, Paris, France;††Société VERTICAL, Paris, France;‡‡Laboratoires FILORGA, Paris, France.

Background: There are requirements for long-term, objective comparisons of hyaluronic acid (HA) dermal fillers.

Objective: To compare efficacy and tolerability of ART FILLER Universal (AFU) and ART FILLER Fine lines (AFFL) with the existing HA fillers for the treatment of nasolabial folds and crow's feet.

Materials And Methods: Prospective, randomized, rater- and patient-blind, split-face comparison of AFU with JUVEDERM Ultra 3 (JUV) and AFFL with FIRST LINES PureSense (FLPS). Read More

Mater Sci Eng C Mater Biol Appl 2017 Sep 20;78:806-816. Epub 2017 Apr 20.

Airbus Operations S. L., John Lennon s/n, 28906 Getafe, Madrid, Spain.

Antibacterial and biocompatible SnO2 nanorods have been easily synthesized through a hydrothermal process with the aid of a cationic surfactant, and incorporated as nanoreinforcements in poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) copolymer crosslinked with N-vinyl-pyrrolidone (NVP) by sonication and thermal curing. The nanorods were randomly and individually dispersed inside the P(PF-co-EG) network, and noticeably increased the thermal stability, hydrophilicity, degree of crystallinity, protein absorption capability as well as stiffness and strength of the matrix, whilst decreased its level of porosity and biodegradation rate. More importantly, the resulting nanocomposites retained adequate rigidity and strength after immersion in a simulated body fluid (SBF) at 37°C. Read More

Facial Plast Surg 2017 Jun 1;33(3):279-284. Epub 2017 Jun 1.

Facial Plastic Surgery Associates, 6655 Travis Street, Suite 900, Houston, Texas.

The traditional rhytidectomy addresses facial and neck aging as it relates to soft tissue laxity. The modern volumetric facelift provides optimal results by addressing not only skin laxity but also the loss of volume secondary to tissue atrophy and bony resorption. While multiple techniques including fat grafting, dermal fillers, and tissue resuspension are used to correct the tissue loss, alloplastic midface augmentation remains the most permanent method. Read More

Aesthetic Plast Surg 2017 May 31. Epub 2017 May 31.

Plastic Surgery Unit, Istituto Nazionale dei Tumori, Milan, Italy.

Demand for non-surgical rejuvenating procedure is constantly increasing due to the aging population, increasing expense of aesthetics and beauty procedures, introduction of new applications and rising demand for noninvasive aesthetic procedures over surgical procedures. Skin necrosis is a rare but severe potential complication. It is caused by impediment of the blood supply to the skin area by compression and/or obstruction of the vessel with filler material, and/or direct injury to the vessel. Read More

Dermatol Surg 2017 May 22. Epub 2017 May 22.

*SkinCare Physicians, Chestnut Hill, Massachusetts;†Department of Dermatology, Boston Medical Center, Boston, Massachusetts.

Background: The numbers of minimally invasive cosmetic procedures performed in the United States have steadily increased each year. Concurrently, the rates of filler complications have also increased. Delayed filler reactions and granulomas have recently been attributed to biofilm infections. Read More

Plast Reconstr Surg Glob Open 2017 Apr 20;5(4):e1285. Epub 2017 Apr 20.

Clinical Department, Awesomemed Dermatology Clinic, Hsinchu, Taiwan; and Department of Medical Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.

With increasing use of dermal fillers, more and more adverse effects are reported. The most devastating one is intravascular injection. We propose a novel needle prototype that allows physicians to prevent intravascular injection. Read More

Dermatol Surg 2017 Jun;43(6):841-847

*Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; †Marmur Medical, New York, New York; ‡Department of Dermatology, The Mount Sinai Hospital, New York, New York.

Background: Hyaluronidase is an enzyme capable of dissolution of hyaluronic acid (HA). There is a lack of evidence-based research defining time- and concentration-dependent reversal of HA filler using hyaluronidase.

Objective: To explore the efficacy of different concentrations of hyaluronidase in digesting commercially available HA-based reversible fillers-Belotero Balance (BEL), Juvederm Ultra XC (JUVXC), Juvederm Ultra Plus (JUVX+), Juvederm Voluma XC (JUVV), Restylane-L (RESL), Restylane Silk (RESS), and Perlane/Restylane Lyft (RESLYFT). Read More

Plast Reconstr Surg 2017 May;139(5):1103-1108

Dallas, Texas; and San Francisco, Calif. From the Dallas Plastic Surgery Institute and Sieber Plastic Surgery.

Given the short recovery and immediate results, facial fillers have become a popular alternative to surgical rejuvenation of the face. Reported complications arising from facial filler injections include erythema, tissue loss, blindness, stroke, and even death. In this article, the authors describe their anatomically based techniques to minimize risk and maximize safety when injecting in the facial danger zones, including the glabella/brow, temporal region, perioral region, nasolabial fold, nose, and infraorbital region. Read More

Aesthetic Plast Surg 2017 Jun 14;41(3):667-677. Epub 2017 Apr 14.

Clínica de Medicina Estética Dra Villanueva, Carrer de Calvet 10, Barcelona, Spain.

Background: The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid these complications. Indeed, a well-trained physician can also minimize the impact of such problems when they do occur. Read More

Aesthet Surg J 2017 05;37(suppl_1):S45-S58

Dermatologist in private practice in Miami, FL, USA.

BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

J Cosmet Laser Ther 2017 Feb 28:1-3. Epub 2017 Feb 28.

b Department of Dermatology , University of California, Irvine , Irvine , CA , USA.

Objective: The most commonly used dermal fillers are hyaluronic acids (HAs), and in general, are well tolerated with mild to moderate risk of adverse events. The most frequently reported side effects are injection site erythema and bruising. We present the first case of a patient who developed a severe granulomatous foreign body reaction to the HA filler, Belotero Balance. Read More

Sci Rep 2017 Mar 23;7:45070. Epub 2017 Mar 23.

United States Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry and Materials Science, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA.

While surgical site preparation has been extensively studied, there is little information about resistance of skin microbiota in the biofilm form to antimicrobial decontamination, and there are no quantitative models to study how biofilm might be transferred into sterile tissue/implant materials during injections for joint spine and tendon, aspiration biopsies and dermal fillers (DF). In this work, we develop two in vitro models to simulate the process of skin preparation and DF injection using pig skin and SimSkin (silicone) materials, respectively. Using the pig skin model, we tested three of the most common skin preparation wipes (alcohol, chlorhexidine and povidone iodine) and found that during wiping they reduced the biofilm bacterial burden of S. Read More

Dermatol Surg 2017 Jul;43(7):967-970

Departments of *Dermatology and †Microbiology, King Saud University, Riyadh, Saudi Arabia.

Background: Hyaluronic acid (HA) gel fillers represent most soft tissue augmentation procedures currently used, because they have lower rates of complications compared with other materials. Many patients do not consume an entire syringe of filler but may require a retouch or intermittent augmentation after some time. The remaining material is commonly stored in a specific environment for reuse by the same patient. Read More

Int J Biol Macromol 2017 Jun 9;99:692-698. Epub 2017 Mar 9.

Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, PR China. Electronic address:

Polysialic acid (PSA) and hyaluronan (HA) are non-immunogenic and biodegradable natural polysaccharides, but HA belongs to glycosaminoglycans and can be immediately degraded by human enzymes. In this study, we synthesized a novel PSA-HA draft copolymer to improve HA stability in vivo. This draft copolymer was characterized by SEM, element analysis and Zeta potential. Read More

Zhonghua Kou Qiang Yi Xue Za Zhi 2017 Mar;52(3):194-197

The Six Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100144, China.

Objective: To evaluate the clinical effect of injectable modified sodium hyaluronate gel filler in the treatment of facial profile modification and rejuvenation. Methods: A total of 125 patients who received facial injection of hyaluronate gel from October 2013 to October 2015 were collected. The patients included 62 cases for rhinoplasty, 28 for chin augmentation, 20 for nasolabial fold correction and 15 for lacrimal groove correction. Read More

Plast Surg Nurs 2017 Jan/Mar;37(1):25-31

Tracey A. Hotta, BScN, RN, CPSN, CANS, is the owner and president of TH Medical Aesthetics. She is the past president of ASPSN, Editor of the Plastic Surgical Nursing journal, and a member of the Board of Directors of the Canadian Society of Plastic Surgical Nurses.

Plast Surg Nurs 2017 Jan/Mar;37(1):23-24

Kathryn A. Woodcock, RN, is the owner and president of Inclusive Clinical Solutions Inc., North Vancouver, British Columbia, Canada.

Treatment with neuromodulators is the most common nonsurgical cosmetic procedure globally and on the increase. However, there are times when a cosmetic treatment crosses over into a medical treatment. When we take the time to make a proper assessment and create a comprehensive treatment plan, we ensure we are providing best practices that result in the best outcome for our patients. Read More

Plast Reconstr Surg 2017 Mar;139(3):613-621

Sydney, New South Wales, and Melbourne, Victoria, Australia From the Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University; and the University of Melbourne.

Background: The development of chronic nodules and granulomatous inflammation after filler injections has been attributed to bacterial biofilm infection. The authors aimed to investigate the relationship between filler and bacterial biofilm using a combined in vitro and in vivo study.

Methods: In vitro assays to investigate the ability of filler materials to support the growth of Staphylococcus epidermidis biofilm and the effect of multiple needle passes through a biofilm-contaminated surface were designed. Read More

Facial Plast Surg 2017 Feb 22;33(1):87-96. Epub 2017 Feb 22.

Department of Life Science and Biotechnology, Universita degli Studi di Ferrara Dipartimento di Scienze della Vita e Biotecnologie, Ferrara, Emilia-Romagna, Italy.

Over the last years, hyaluronic acid (HA) injectable dermal fillers (DFs) have become the most popular agents for soft tissue contouring and volumizing. HA fillers are characterized by most of the properties that an ideal DF should have, due to HA unique chemical-physical properties, biocompatibility, biodegradability, and versatility. Therefore, HA DFs have revolutionized the filler market with a high number of products, which differ in terms of HA source, cross-linkage (agent and degree), HA concentration, hardness, cohesivity, consistency, inclusion or lack of anesthetic, indication, and longevity of correction. Read More

Plast Reconstr Surg Glob Open 2017 Jan 16;5(1):e1133. Epub 2017 Jan 16.

Peking University Third Hospital, Beijing, China (D.L.); Shanghai 9th People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (Y.X., Qingfeng Li); General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guang Dong, China (Qin Li); Union Hospital of Tongji Medical College of HUST, Wuhan, Hubei, China (J.S.); Nanfang Hospital, Southern Medical University, Guangzhou, China (P.J.); Allergan China, Beijing, China (Y.J.); and Allergan plc, Irvine, Calif., (D.K.M.).

Background: Hyaluronic acid dermal fillers are effective in correcting severe nasolabial folds (NLFs) in non-Asian populations. We assessed safety and effectiveness of Juvéderm Ultra Plus in a Chinese population.

Methods: This double-blind study randomized Chinese subjects with severe NLFs to Juvéderm Ultra Plus (24 mg/mL) in 1 NLF and Restylane injectable gel (20 mg/mL) in the other NLF. Read More

Dermatol Surg 2017 Feb;43(2):238-245

*Rosenpark Research, Darmstadt, Germany;†Cologne Dermatology, Köln, Germany;‡Elzen Kliniek, Noord-Holland, Netherlands;§Allergan, Ltd., Marlow, United Kingdom (former Allergan employees);‖Allergan plc, Irvine, California;¶Allergan plc, Marlow, United Kingdom.

Background: VYC-17.5L (17.5 mg/mL hyaluronic acid, 0. Read More

J Cutan Aesthet Surg 2016 Oct-Dec;9(4):244-248

Department of Dermatology, Venereology and Leprology, Bengaluru Medical College and Research Institute, Bengaluru, Karnataka, India.

Background: Scars over the face are cosmetically and psychologically disturbing. Various techniques have been described and are being practiced in the management of these scars.

Aims And Objectives: This study was undertaken to study the safety, effectiveness of using dermal grafts as fillers in the management of facial scars due to acne, chickenpox, trauma or any others. Read More

J Drugs Dermatol 2016 Dec;15(12):1536-1542

Background: The desire for and use of nonsurgical injectable esthetic facial treatments is on a rise in Asia. Recent advances, including more versatile facial fillers, refined injection techniques, and adoption of a global facial approach, have in turn contributed to improved patient outcomes and increased patient satisfaction. The sought after nonsurgical treatments include the use of botulinum toxin, con- touring of the face with soft tissue fillers, and thinning of the face with injection lipolysis. Read More

J Drugs Dermatol 2016 Dec;15(12):1524-1531

This paper aims to review articles related to facial fillers in the periorbital area, forehead, and temple. Anatomy, anatomical changes with aging, techniques of rejuvenation and facial harmonization with fillers are reviewed. Topics for complication prevention and management including knowledge of danger zones, timing of hyaluronidase injections, aspiration, definition a small aliquot, and thoughts about particle size are discussed. Read More

Plast Reconstr Surg 2017 May;139(5):1075-1082

Roseau, Commonwealth of Dominica; Salzburg and Vienna, Austria; and Kiel, Munich, Tuebingen, and Luebeck, Germany From the Department of Anatomy, Ross University School of Medicine; the Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg; the Center of Anatomy and Cell Biology, Division of Anatomy, Medical University of Vienna; the Institute of Anatomy, Christian-Albrechts-University of Kiel; the Department of Hand, Plastic, and Aesthetic Surgery, Ludwig-Maximilians University; the Institute of Anatomy, Department of Clinical Anatomy and Cell Analysis, University of Tuebingen; and the Institute of Anatomy, University of Luebeck.

Background: Understanding the precise position and course of the superior and inferior labial arteries within the upper lip and the lower lip is crucial for safe and complication-free applications of volumizing materials.

Methods: One hundred ninety-three anatomical head specimens (56.5 percent female cadavers) of Caucasian ethnicity were investigated in this large multicenter anatomical study. Read More

Ann Chir Plast Esthet 2017 Jun 6;62(3):261-267. Epub 2017 Jan 6.

Service de chirurgie maxillofaciale et de chirurgie plastique, réparatrice et esthétique, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.

Hyaluronic acid (HA) is the most widely used dermal filler to treat facial volume deficits and winkles specially for facial rejuvenation. Depending on various areas of the face, filler is exposed to two different forces (shear deformation and compression/stretching forces) resulting from intrinsec and external mechanical stress. The purpose of this technical note is to explain how rheology, which is the study of the flow and deformation of matter under strains, can be used in our clinical practice of facial volumization with fillers. Read More

Cutis 2016 Nov;98(5):309-313

Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Many dermal fillers are available for various cosmetic rejuvenation purposes including but not limited to treatment of facial rhytides, nasolabial folds (NLFs), facial volume deficits, and lipoatrophy; facial contouring; and lip and/or cheek augmentation. To update clinicians on best practices, we review the efficacy and safety data on the most recently approved dermal fillers. Read More

Cutis 2016 Nov;98(5):330-335

Departments of Ophthalmology and Dermatology, Duke University Medical Center, Durham, North Carolina, USA.

Aging of the periocular area involves changes of the skin, muscle, fat, and bones. Facial fillers can be helpful in minimizing these changes by restoring youthful fullness to periocular areas that have undergone volume loss or loss of support. Physicians should understand the complicated anatomy surrounding the eyes, both to understand the aging process and to minimize treatment complications. Read More

Cutis 2016 Nov;98(5):325-329

Weill Cornell Medical College, New York, New York, USA.

Facial rejuvenation, particularly lip augmentation, has gained widespread popularity. An appreciation of perioral anatomy as well as the structural characteristics that define the aging face is critical to achieve optimal patient outcomes. Although techniques and technology evolve continuously, hyaluronic acid (HA) dermal fillers continue to dominate aesthetic practice. Read More

Facial Plast Surg 2016 Dec 29;32(6):671-682. Epub 2016 Dec 29.

Department of Anatomy, Ross University School of Medicine, Roseau, West Indies.

Recent advantages in the anatomical understanding of the face have turned the focus toward the subcutaneous and deep facial fat compartments. During facial aging, these fat-filled compartments undergo substantial changes along with other structures in the face. Soft tissue filler and fat grafting are valid methods to fight the signs of facial aging, but little is known about their precise effect on the facial fat. Read More

Aesthetic Plast Surg 2017 Apr 28;41(2):422-428. Epub 2016 Dec 28.

Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14584, Republic of Korea.

Background: Injection-related pain of dermal fillers is a consistent and bothersome problem for patients undergoing soft tissue augmentation. Reducing the pain could improve overall patient satisfaction.

Objective: The purpose of this study was to compare the pain relief, efficacy, and safety of HA IDF plus containing lidocaine with HA IDF without lidocaine during correction of nasolabial folds (NLFs). Read More

Aesthetic Plast Surg 2017 Feb 28;41(1):199-203. Epub 2016 Dec 28.

Division of Plastic Surgery, Voluntary Clinical Faculty, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.

Soft tissue filler injections are the second most common non-surgical procedure performed by the plastic surgeon. Embolization of intravascular material after facial injection is a rare but terrifying outcome due to the high likelihood of long-term sequela such as blindness and cerebrovascular accident. The literature is replete with examples of permanent blindness caused by injection with autologous fat, soft tissue fillers such as hyaluronic acid, PLLA, calcium hydroxyl-apatite, and even corticosteroid suspensions. Read More

Plast Reconstr Surg 2017 Jan;139(1):50e-58e

Dallas, Texas From the Department of Plastic Surgery, University of Texas Southwestern Medical Center.

With limited downtime and immediate results, facial filler injections are becoming an ever more popular alternative to surgical rejuvenation of the face. The results, and the complications, can be impressive. To maximize safety during injections, the authors have outlined general injection principles followed by pertinent anatomy within six different facial danger zones. Read More

Aesthet Surg J 2017 05;37(5):582-587

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Operative experience in aesthetic surgery is an important issue affecting plastic surgery residents.

Objectives: This study addresses the variability of aesthetic surgery experience during plastic surgery residency.

Methods: National operative case logs of chief residents in independent/combined and integrated plastic surgery residency programs were analyzed (2011-2015). Read More

Aesthet Surg J 2017 04;37(4):448-453

Medical Student, New York Institute of Technology, College of Osteopathic Medicine, New York, USA.

Background: Facial rejuvenation in patients younger than 50 years of age has experienced an unprecedented growth with multimodality nonsurgical and less invasive rhytidectomy techniques.

Objectives: To analyze the nonsurgical treatment habits of patients prior to undergoing rhytidectomy at <50 years of age.

Methods: Retrospective study to enlist patients who underwent primary rhytidectomy at age <50 years between January 1, 2003 and December 31, 2013 by the senior author (AAJ) to complete a survey. Read More

Dermatol Surg 2017 Feb;43(2):246-254

*State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R.China; †Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China; ‡National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.

Background: Hyaluronidase is a key preventative treatment against vascular complications of hyaluronic acid (HA) filler injection, but the degradation profile of HA to hyaluronidase is limited, and the comparison between intra-arterial and subcutaneous injections of hyaluronidase has not been studied.

Objective: To evaluate HA degradation to hyaluronidase and compare different treatments between intra-arterial and subcutaneous testicular hyaluronidase injections.

Materials And Methods: The authors observed HA degradation to hyaluronidase in vitro via microscopic examination and particle analysis. Read More

J Cosmet Laser Ther 2017 Feb 2;19(1):59-63. Epub 2016 Dec 2.

i Department of Advanced Biomedical Sciences , Pathology Section, University of Naples Federico II , Naples , Italy.

According to the American Academy of Aesthetic Plastic Surgeons, more than 11 million cosmetic surgical and nonsurgical procedures were performed by board-certified plastic surgeons, dermatologists and otolaryngologists in the United States, totaling more than 12 billion dollars. We performed a retrospective observational multi-centric study on patients treated with a non-animal origin cross-linked hyaluronic acid with different molecular weights for nasolabial folds, evaluating through a new imaging system, profilometric techniques with the confocal microscopy, the durability, the efficacy and the safety of this product. From 25 patients, 150 silicone casts were obtained: 75 casts of the right nasolabial fold and 75 casts of the left nasolabial fold. Read More

Ann Dermatol 2016 Dec 23;28(6):753-756. Epub 2016 Nov 23.

Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Injectable poly-L-lactic acid (PLLA) is world-famous filler used in lipoatrophy and facial rejuvenation because of its collagen neogenesis effect which leads to gradual volume restoration. Until recently, quite a number of unwanted adverse events of PLLA have been reported. However, to the best of our knowledge, paraffinoma as a complication of PLLA has never been reported. Read More

Facial Plast Surg Clin North Am 2017 Feb;25(1):55-71

Facial Plastic and Reconstructive Surgery, Penn State Hershey Medical Center, 500 University Drive H091, Hershey, PA 17033, USA; Fedok Plastic Surgery, 113 East Fern Avenue, Foley, AL 36535, USA; Department of Surgery, USA Medical Center, The University of South Alabama, 2451 Fillingim Street, Mobile, AL 36617, USA. Electronic address:

Lip and chin scarring occurs owing to reconstruction of congenital, cancer resection, or traumatic defects. Knowledge of lip anatomy and function is critical to optimize results. Realistic expectations should be established before intervention. Read More

Facial Plast Surg Clin North Am 2017 Feb;25(1):45-54

UC Irvine Department of Head & Neck Surgery, 101 The City Drive South, Orange, CA 92868, USA. Electronic address:

Various methods are available for refining scars of the external nose and optimal scar revision frequently requires the utilization of multiple techniques. Differing anatomy of nasal subunits and their underlying structural framework limit surgical options in nasal scar revision compared with other areas of the face. An understanding of a variety of laser technologies and their specific applications can vastly aid in fine, controlled scar revision. Read More