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    Prospective, Split-Face, Randomized, Long-Term Blinded Objective Comparison of the Performance and Tolerability of Two New Hyaluronic Acid Fillers.
    Dermatol Surg 2017 Jun 6. Epub 2017 Jun 6.
    *Clinique REMUSAT, Paris, France;†Private Practice, Paris, France;‡Private Practice, Paris, France;§Private Practice, Paris, France;¶Fondation Rothschild, Paris, France;‖Private Practice, Paris, France;**GREDECO, Paris, France;††Société VERTICAL, Paris, France;‡‡Laboratoires FILORGA, Paris, France.
    Background: There are requirements for long-term, objective comparisons of hyaluronic acid (HA) dermal fillers.

    Objective: To compare efficacy and tolerability of ART FILLER Universal (AFU) and ART FILLER Fine lines (AFFL) with the existing HA fillers for the treatment of nasolabial folds and crow's feet.

    Materials And Methods: Prospective, randomized, rater- and patient-blind, split-face comparison of AFU with JUVEDERM Ultra 3 (JUV) and AFFL with FIRST LINES PureSense (FLPS). Read More

    Antibacterial SnO2 nanorods as efficient fillers of poly(propylene fumarate-co-ethylene glycol) biomaterials.
    Mater Sci Eng C Mater Biol Appl 2017 Sep 20;78:806-816. Epub 2017 Apr 20.
    Airbus Operations S. L., John Lennon s/n, 28906 Getafe, Madrid, Spain.
    Antibacterial and biocompatible SnO2 nanorods have been easily synthesized through a hydrothermal process with the aid of a cationic surfactant, and incorporated as nanoreinforcements in poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) copolymer crosslinked with N-vinyl-pyrrolidone (NVP) by sonication and thermal curing. The nanorods were randomly and individually dispersed inside the P(PF-co-EG) network, and noticeably increased the thermal stability, hydrophilicity, degree of crystallinity, protein absorption capability as well as stiffness and strength of the matrix, whilst decreased its level of porosity and biodegradation rate. More importantly, the resulting nanocomposites retained adequate rigidity and strength after immersion in a simulated body fluid (SBF) at 37°C. Read More

    Cheek and Chin Implants to Enhance Facelift Results.
    Facial Plast Surg 2017 Jun 1;33(3):279-284. Epub 2017 Jun 1.
    Facial Plastic Surgery Associates, 6655 Travis Street, Suite 900, Houston, Texas.
    The traditional rhytidectomy addresses facial and neck aging as it relates to soft tissue laxity. The modern volumetric facelift provides optimal results by addressing not only skin laxity but also the loss of volume secondary to tissue atrophy and bony resorption. While multiple techniques including fat grafting, dermal fillers, and tissue resuspension are used to correct the tissue loss, alloplastic midface augmentation remains the most permanent method. Read More

    Impending Facial Skin Necrosis and Ocular Involvement After Dermal Filler Injection: A Case Report.
    Aesthetic Plast Surg 2017 May 31. Epub 2017 May 31.
    Plastic Surgery Unit, Istituto Nazionale dei Tumori, Milan, Italy.
    Demand for non-surgical rejuvenating procedure is constantly increasing due to the aging population, increasing expense of aesthetics and beauty procedures, introduction of new applications and rising demand for noninvasive aesthetic procedures over surgical procedures. Skin necrosis is a rare but severe potential complication. It is caused by impediment of the blood supply to the skin area by compression and/or obstruction of the vessel with filler material, and/or direct injury to the vessel. Read More

    Filler Nodules: Inflammatory or Infectious? A Review of Biofilms and Their Implications on Clinical Practice.
    Dermatol Surg 2017 May 22. Epub 2017 May 22.
    *SkinCare Physicians, Chestnut Hill, Massachusetts;†Department of Dermatology, Boston Medical Center, Boston, Massachusetts.
    Background: The numbers of minimally invasive cosmetic procedures performed in the United States have steadily increased each year. Concurrently, the rates of filler complications have also increased. Delayed filler reactions and granulomas have recently been attributed to biofilm infections. Read More

    A Novel Needle Structure that Can Avoid Intravascular Injection of Any Filler.
    Plast Reconstr Surg Glob Open 2017 Apr 20;5(4):e1285. Epub 2017 Apr 20.
    Clinical Department, Awesomemed Dermatology Clinic, Hsinchu, Taiwan; and Department of Medical Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.
    With increasing use of dermal fillers, more and more adverse effects are reported. The most devastating one is intravascular injection. We propose a novel needle prototype that allows physicians to prevent intravascular injection. Read More

    Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report.
    Aesthetic Plast Surg 2017 Jun 14;41(3):667-677. Epub 2017 Apr 14.
    Clínica de Medicina Estética Dra Villanueva, Carrer de Calvet 10, Barcelona, Spain.
    Background: The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid these complications. Indeed, a well-trained physician can also minimize the impact of such problems when they do occur. Read More

    New Uses of AbobotulinumtoxinA in Aesthetics.
    Aesthet Surg J 2017 May;37(suppl_1):S45-S58
    Dr Schlessinger is a dermatologist and cosmetic surgeon in private practice in Omaha, NE. Dr Gilbert is a dermatologist in private practice in Brooklyn, NY. Dr Cohen is a dermatologist in private practice in Greenwood Village, CO. Dr Kaufman is dermatologist in private practice in Miami, FL.
    BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

    Granulomatous reaction to Belotero Balance: A case study.
    J Cosmet Laser Ther 2017 Feb 28:1-3. Epub 2017 Feb 28.
    b Department of Dermatology , University of California, Irvine , Irvine , CA , USA.
    Objective: The most commonly used dermal fillers are hyaluronic acids (HAs), and in general, are well tolerated with mild to moderate risk of adverse events. The most frequently reported side effects are injection site erythema and bruising. We present the first case of a patient who developed a severe granulomatous foreign body reaction to the HA filler, Belotero Balance. Read More

    Injections through skin colonized with Staphylococcus aureus biofilm introduce contamination despite standard antimicrobial preparation procedures.
    Sci Rep 2017 Mar 23;7:45070. Epub 2017 Mar 23.
    United States Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry and Materials Science, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA.
    While surgical site preparation has been extensively studied, there is little information about resistance of skin microbiota in the biofilm form to antimicrobial decontamination, and there are no quantitative models to study how biofilm might be transferred into sterile tissue/implant materials during injections for joint spine and tendon, aspiration biopsies and dermal fillers (DF). In this work, we develop two in vitro models to simulate the process of skin preparation and DF injection using pig skin and SimSkin (silicone) materials, respectively. Using the pig skin model, we tested three of the most common skin preparation wipes (alcohol, chlorhexidine and povidone iodine) and found that during wiping they reduced the biofilm bacterial burden of S. Read More

    The Sterility of Partially Used Hyaluronic Acid Fillers After Long Storage.
    Dermatol Surg 2017 Jul;43(7):967-970
    Departments of *Dermatology and †Microbiology, King Saud University, Riyadh, Saudi Arabia.
    Background: Hyaluronic acid (HA) gel fillers represent most soft tissue augmentation procedures currently used, because they have lower rates of complications compared with other materials. Many patients do not consume an entire syringe of filler but may require a retouch or intermittent augmentation after some time. The remaining material is commonly stored in a specific environment for reuse by the same patient. Read More

    Preparation and characterization of a novel polysialic acid-hyaluronan graft copolymer potential as dermal filler.
    Int J Biol Macromol 2017 Jun 9;99:692-698. Epub 2017 Mar 9.
    Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, PR China. Electronic address:
    Polysialic acid (PSA) and hyaluronan (HA) are non-immunogenic and biodegradable natural polysaccharides, but HA belongs to glycosaminoglycans and can be immediately degraded by human enzymes. In this study, we synthesized a novel PSA-HA draft copolymer to improve HA stability in vivo. This draft copolymer was characterized by SEM, element analysis and Zeta potential. Read More

    Postparalytic Hemifacial Spasm: A Case Study.
    Plast Surg Nurs 2017 Jan/Mar;37(1):23-24
    Kathryn A. Woodcock, RN, is the owner and president of Inclusive Clinical Solutions Inc., North Vancouver, British Columbia, Canada.
    Treatment with neuromodulators is the most common nonsurgical cosmetic procedure globally and on the increase. However, there are times when a cosmetic treatment crosses over into a medical treatment. When we take the time to make a proper assessment and create a comprehensive treatment plan, we ensure we are providing best practices that result in the best outcome for our patients. Read More

    The Role of Bacterial Biofilm in Adverse Soft-Tissue Filler Reactions: A Combined Laboratory and Clinical Study.
    Plast Reconstr Surg 2017 Mar;139(3):613-621
    Sydney, New South Wales, and Melbourne, Victoria, Australia From the Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University; and the University of Melbourne.
    Background: The development of chronic nodules and granulomatous inflammation after filler injections has been attributed to bacterial biofilm infection. The authors aimed to investigate the relationship between filler and bacterial biofilm using a combined in vitro and in vivo study.

    Methods: In vitro assays to investigate the ability of filler materials to support the growth of Staphylococcus epidermidis biofilm and the effect of multiple needle passes through a biofilm-contaminated surface were designed. Read More

    Hyaluronic Acid Fillers in Soft Tissue Regeneration.
    Facial Plast Surg 2017 Feb 22;33(1):87-96. Epub 2017 Feb 22.
    Department of Life Science and Biotechnology, Universita degli Studi di Ferrara Dipartimento di Scienze della Vita e Biotecnologie, Ferrara, Emilia-Romagna, Italy.
    Over the last years, hyaluronic acid (HA) injectable dermal fillers (DFs) have become the most popular agents for soft tissue contouring and volumizing. HA fillers are characterized by most of the properties that an ideal DF should have, due to HA unique chemical-physical properties, biocompatibility, biodegradability, and versatility. Therefore, HA DFs have revolutionized the filler market with a high number of products, which differ in terms of HA source, cross-linkage (agent and degree), HA concentration, hardness, cohesivity, consistency, inclusion or lack of anesthetic, indication, and longevity of correction. Read More

    Safety and Effectiveness of Juvéderm Ultra Plus Injectable Gel in Correcting Severe Nasolabial Folds in Chinese Subjects.
    Plast Reconstr Surg Glob Open 2017 Jan 16;5(1):e1133. Epub 2017 Jan 16.
    Peking University Third Hospital, Beijing, China (D.L.); Shanghai 9th People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (Y.X., Qingfeng Li); General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guang Dong, China (Qin Li); Union Hospital of Tongji Medical College of HUST, Wuhan, Hubei, China (J.S.); Nanfang Hospital, Southern Medical University, Guangzhou, China (P.J.); Allergan China, Beijing, China (Y.J.); and Allergan plc, Irvine, Calif., (D.K.M.).
    Background: Hyaluronic acid dermal fillers are effective in correcting severe nasolabial folds (NLFs) in non-Asian populations. We assessed safety and effectiveness of Juvéderm Ultra Plus in a Chinese population.

    Methods: This double-blind study randomized Chinese subjects with severe NLFs to Juvéderm Ultra Plus (24 mg/mL) in 1 NLF and Restylane injectable gel (20 mg/mL) in the other NLF. Read More

    A Prospective, Open-Label, Observational, Postmarket Study Evaluating VYC-17.5L for the Correction of Moderate to Severe Nasolabial Folds Over 12 Months.
    Dermatol Surg 2017 Feb;43(2):238-245
    *Rosenpark Research, Darmstadt, Germany;†Cologne Dermatology, Köln, Germany;‡Elzen Kliniek, Noord-Holland, Netherlands;§Allergan, Ltd., Marlow, United Kingdom (former Allergan employees);‖Allergan plc, Irvine, California;¶Allergan plc, Marlow, United Kingdom.
    Background: VYC-17.5L (17.5 mg/mL hyaluronic acid, 0. Read More

    Outcome of Dermal Grafting in the Management of Atrophic Facial Scars.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):244-248
    Department of Dermatology, Venereology and Leprology, Bengaluru Medical College and Research Institute, Bengaluru, Karnataka, India.
    Background: Scars over the face are cosmetically and psychologically disturbing. Various techniques have been described and are being practiced in the management of these scars.

    Aims And Objectives: This study was undertaken to study the safety, effectiveness of using dermal grafts as fillers in the management of facial scars due to acne, chickenpox, trauma or any others. Read More

    Facial Contouring With Fillers, Neuromodulators, and Lipolysis to Achieve a Natural Look in Patients With Facial Fullness.
    J Drugs Dermatol 2016 Dec;15(12):1536-1542
    Background: The desire for and use of nonsurgical injectable esthetic facial treatments is on a rise in Asia. Recent advances, including more versatile facial fillers, refined injection techniques, and adoption of a global facial approach, have in turn contributed to improved patient outcomes and increased patient satisfaction. The sought after nonsurgical treatments include the use of botulinum toxin, con- touring of the face with soft tissue fillers, and thinning of the face with injection lipolysis. Read More

    Review of Periorbital and Upper Face: Pertinent Anatomy, Aging, Injection Techniques, Prevention, and Management of Complications of Facial Fillers.
    J Drugs Dermatol 2016 Dec;15(12):1524-1531
    This paper aims to review articles related to facial fillers in the periorbital area, forehead, and temple. Anatomy, anatomical changes with aging, techniques of rejuvenation and facial harmonization with fillers are reviewed. Topics for complication prevention and management including knowledge of danger zones, timing of hyaluronidase injections, aspiration, definition a small aliquot, and thoughts about particle size are discussed. Read More

    [Hyaluronic acid rheology: Basics and clinical applications in facial rejuvenation].
    Ann Chir Plast Esthet 2017 Jun 6;62(3):261-267. Epub 2017 Jan 6.
    Service de chirurgie maxillofaciale et de chirurgie plastique, réparatrice et esthétique, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
    Hyaluronic acid (HA) is the most widely used dermal filler to treat facial volume deficits and winkles specially for facial rejuvenation. Depending on various areas of the face, filler is exposed to two different forces (shear deformation and compression/stretching forces) resulting from intrinsec and external mechanical stress. The purpose of this technical note is to explain how rheology, which is the study of the flow and deformation of matter under strains, can be used in our clinical practice of facial volumization with fillers. Read More

    Efficacy and safety of new dermal fillers.
    Cutis 2016 Nov;98(5):309-313
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Many dermal fillers are available for various cosmetic rejuvenation purposes including but not limited to treatment of facial rhytides, nasolabial folds (NLFs), facial volume deficits, and lipoatrophy; facial contouring; and lip and/or cheek augmentation. To update clinicians on best practices, we review the efficacy and safety data on the most recently approved dermal fillers. Read More

    Periocular fillers and related anatomy.
    Cutis 2016 Nov;98(5):330-335
    Departments of Ophthalmology and Dermatology, Duke University Medical Center, Durham, North Carolina, USA.
    Aging of the periocular area involves changes of the skin, muscle, fat, and bones. Facial fillers can be helpful in minimizing these changes by restoring youthful fullness to periocular areas that have undergone volume loss or loss of support. Physicians should understand the complicated anatomy surrounding the eyes, both to understand the aging process and to minimize treatment complications. Read More

    Current concepts in lip augmentation.
    Cutis 2016 Nov;98(5):325-329
    Weill Cornell Medical College, New York, New York, USA.
    Facial rejuvenation, particularly lip augmentation, has gained widespread popularity. An appreciation of perioral anatomy as well as the structural characteristics that define the aging face is critical to achieve optimal patient outcomes. Although techniques and technology evolve continuously, hyaluronic acid (HA) dermal fillers continue to dominate aesthetic practice. Read More

    The Facial Adipose Tissue: A Revision.
    Facial Plast Surg 2016 Dec 29;32(6):671-682. Epub 2016 Dec 29.
    Department of Anatomy, Ross University School of Medicine, Roseau, West Indies.
    Recent advantages in the anatomical understanding of the face have turned the focus toward the subcutaneous and deep facial fat compartments. During facial aging, these fat-filled compartments undergo substantial changes along with other structures in the face. Soft tissue filler and fat grafting are valid methods to fight the signs of facial aging, but little is known about their precise effect on the facial fat. Read More

    The Efficacy and Safety of HA IDF Plus (with Lidocaine) Versus HA IDF (Without Lidocaine) in Nasolabial Folds Injection: A Randomized, Multicenter, Double-Blind, Split-Face Study.
    Aesthetic Plast Surg 2017 Apr 28;41(2):422-428. Epub 2016 Dec 28.
    Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14584, Republic of Korea.
    Background: Injection-related pain of dermal fillers is a consistent and bothersome problem for patients undergoing soft tissue augmentation. Reducing the pain could improve overall patient satisfaction.

    Objective: The purpose of this study was to compare the pain relief, efficacy, and safety of HA IDF plus containing lidocaine with HA IDF without lidocaine during correction of nasolabial folds (NLFs). Read More

    Ocular Pain and Impending Blindness During Facial Cosmetic Injections: Is Your Office Prepared?
    Aesthetic Plast Surg 2017 Feb 28;41(1):199-203. Epub 2016 Dec 28.
    Division of Plastic Surgery, Voluntary Clinical Faculty, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
    Soft tissue filler injections are the second most common non-surgical procedure performed by the plastic surgeon. Embolization of intravascular material after facial injection is a rare but terrifying outcome due to the high likelihood of long-term sequela such as blindness and cerebrovascular accident. The literature is replete with examples of permanent blindness caused by injection with autologous fat, soft tissue fillers such as hyaluronic acid, PLLA, calcium hydroxyl-apatite, and even corticosteroid suspensions. Read More

    Anatomy of the Facial Danger Zones: Maximizing Safety during Soft-Tissue Filler Injections.
    Plast Reconstr Surg 2017 Jan;139(1):50e-58e
    Dallas, Texas From the Department of Plastic Surgery, University of Texas Southwestern Medical Center.
    With limited downtime and immediate results, facial filler injections are becoming an ever more popular alternative to surgical rejuvenation of the face. The results, and the complications, can be impressive. To maximize safety during injections, the authors have outlined general injection principles followed by pertinent anatomy within six different facial danger zones. Read More

    Disparities in Aesthetic Procedures Performed by Plastic Surgery Residents.
    Aesthet Surg J 2017 May;37(5):582-587
    From the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
    Background: Operative experience in aesthetic surgery is an important issue affecting plastic surgery residents.

    Objectives: This study addresses the variability of aesthetic surgery experience during plastic surgery residency.

    Methods: National operative case logs of chief residents in independent/combined and integrated plastic surgery residency programs were analyzed (2011-2015). Read More

    Nonsurgical Facial Rejuvenation Procedures in Patients Under 50 Prior to Undergoing Facelift: Habits, Costs, and Results.
    Aesthet Surg J 2017 Apr;37(4):448-453
    Dr Jacono is Section Head, Facial Plastic and Reconstructive Surgery, North Shore University Hospital, Manhasset, NY; and Assistant Clinical Professor of Facial Plastic Surgery, New York Eye and Ear Infirmary and Albert Einstein College of Medicine, New York, NY. Dr Malone is an Assistant Professor, Division of Facial Plastic Surgery, Albert Einstein College of Medicine, New York, NY. Mr Lavin is a Medical Student, New York Institute of Technology, College of Osteopathic Medicine, New York, NY.
    Background: Facial rejuvenation in patients younger than 50 years of age has experienced an unprecedented growth with multimodality nonsurgical and less invasive rhytidectomy techniques.

    Objectives: To analyze the nonsurgical treatment habits of patients prior to undergoing rhytidectomy at <50 years of age.

    Methods: Retrospective study to enlist patients who underwent primary rhytidectomy at age <50 years between January 1, 2003 and December 31, 2013 by the senior author (AAJ) to complete a survey. Read More

    Comparison of Intra-arterial and Subcutaneous Testicular Hyaluronidase Injection Treatments and the Vascular Complications of Hyaluronic Acid Filler.
    Dermatol Surg 2017 Feb;43(2):246-254
    *State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R.China; †Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China; ‡National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
    Background: Hyaluronidase is a key preventative treatment against vascular complications of hyaluronic acid (HA) filler injection, but the degradation profile of HA to hyaluronidase is limited, and the comparison between intra-arterial and subcutaneous injections of hyaluronidase has not been studied.

    Objective: To evaluate HA degradation to hyaluronidase and compare different treatments between intra-arterial and subcutaneous testicular hyaluronidase injections.

    Materials And Methods: The authors observed HA degradation to hyaluronidase in vitro via microscopic examination and particle analysis. Read More

    Late-Onset Complication of Fillers: Paraffinoma of the Lower Eyelids Clinically Mimicking Xanthelasma.
    Ann Dermatol 2016 Dec 23;28(6):753-756. Epub 2016 Nov 23.
    Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
    Injectable poly-L-lactic acid (PLLA) is world-famous filler used in lipoatrophy and facial rejuvenation because of its collagen neogenesis effect which leads to gradual volume restoration. Until recently, quite a number of unwanted adverse events of PLLA have been reported. However, to the best of our knowledge, paraffinoma as a complication of PLLA has never been reported. Read More

    Treating Scars of the Chin and Perioral Region.
    Facial Plast Surg Clin North Am 2017 Feb;25(1):55-71
    Facial Plastic and Reconstructive Surgery, Penn State Hershey Medical Center, 500 University Drive H091, Hershey, PA 17033, USA; Fedok Plastic Surgery, 113 East Fern Avenue, Foley, AL 36535, USA; Department of Surgery, USA Medical Center, The University of South Alabama, 2451 Fillingim Street, Mobile, AL 36617, USA. Electronic address:
    Lip and chin scarring occurs owing to reconstruction of congenital, cancer resection, or traumatic defects. Knowledge of lip anatomy and function is critical to optimize results. Realistic expectations should be established before intervention. Read More

    Unique Clinical Aspects of Nasal Scarring.
    Facial Plast Surg Clin North Am 2017 Feb;25(1):45-54
    UC Irvine Department of Head & Neck Surgery, 101 The City Drive South, Orange, CA 92868, USA. Electronic address:
    Various methods are available for refining scars of the external nose and optimal scar revision frequently requires the utilization of multiple techniques. Differing anatomy of nasal subunits and their underlying structural framework limit surgical options in nasal scar revision compared with other areas of the face. An understanding of a variety of laser technologies and their specific applications can vastly aid in fine, controlled scar revision. Read More

    Management of Forehead Scars.
    Facial Plast Surg Clin North Am 2017 Feb;25(1):15-24
    Department of Otolaryngology - Head & Neck Surgery, Thomas Jefferson University Hospital, Thomas Jefferson University, 925 Chestnut Street, 6th Floor, Philadelphia, PA 19107, USA.
    This article provides an overview of scar management within the forehead region. It addresses the unique challenges specific to the treatment of forehead wounds. A logical, stepwise approach is used. Read More

    Intravenous Hyaluronidase with Urokinase as Treatment for Rabbit Retinal Artery Hyaluronic Acid Embolism.
    Plast Reconstr Surg 2016 Dec;138(6):1221-1229
    Shanghai, People's Republic of China From the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Affiliated to the School of Medicine Shanghai Jiao Tong University.
    Background: Although various salvage methods have been proposed to treat intraretinal artery hyaluronic acid embolism, their applications are still limited by various factors. The authors investigated the effectiveness of intravenous hyaluronidase with urokinase for resolving retinal artery hyaluronic acid embolism.

    Methods: The anatomy of rabbit ophthalmic and fundus arteries (retinal and choroid artery) was studied. Read More

    Filler migration to the forehead due to multiple filler injections in a patient addicted to cosmetic fillers.
    J Cosmet Laser Ther 2017 Apr 25;19(2):124-126. Epub 2017 Jan 25.
    a Department of Dermatology , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.
    Filler migration is a potential complication following the injection of multiple fillers. With the increasing popularity of multiple filler injections, migrated granulomas should be an essential differential diagnosis for newly growing facial lumps. It is important for all physicians to be aware that complication induced by dermal fillers can occur in locations other than the planned injected sites. Read More

    Safety and Efficacy of a Volumizing Hyaluronic Acid Filler for Treatment of HIV-Associated Facial Lipoatrophy.
    JAMA Dermatol 2017 Jan;153(1):61-65
    Dermatology Service, Sacramento Veterans Affairs Medical Center, Mather, California2Department of Dermatology, University of California, Davis, Sacramento3Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn.
    Importance: Facial lipoatrophy (FLA) is associated with human immunodeficiency virus (HIV) disease and the use of highly active antiretroviral therapy. The condition is primarily characterized by facial volume loss that affects the contours of the cheeks, temples, and orbits and may negatively affect patients' adherence to highly active antiretroviral therapy, psychological health, and quality of life. A single treatment of hyaluronic acid (HA) filler, 20 mg/mL, may provide an immediate, natural-appearing facial enhancement outcome. Read More

    Safety and performance of cohesive polydensified matrix hyaluronic acid fillers with lidocaine in the clinical setting - an open-label, multicenter study.
    Clin Cosmet Investig Dermatol 2016 20;9:373-381. Epub 2016 Oct 20.
    Rosenparkklinik GmbH, Darmstadt, Germany.
    Cohesive polydensified matrix (CPM(®)) hyaluronic acid fillers are now available with or without lidocaine. The aim of this study was to investigate the safety and performance of CPM(®) fillers with lidocaine in the clinical setting. In an open-label, prospective, postmarketing study, 108 patients from seven sites in Germany and Denmark were treated with one or more lidocaine-containing CPM(®) fillers. Read More

    Dermal fillers: pathophysiology, prevention and treatment of complications.
    J Eur Acad Dermatol Venereol 2017 Mar 28;31(3):405-413. Epub 2016 Oct 28.
    Department of Surgery and Laser Unit, St. John's Institute of Dermatology, Guy's and St. Thomas' Hospitals, London, UK.
    Dermal fillers are increasingly used for soft tissue augmentation of the face and hands. The widespread use of dermal fillers for rejuvenation has led to a rise in reports of associated complications. Although the majority of complications are mild and transient, serious and long-lasting complications have been observed. Read More

    Safety and Long-Term Efficacy of Forehead Contouring With a Polycaprolactone-Based Dermal Filler.
    Dermatol Surg 2016 Nov;42(11):1256-1260
    Hus-Hu Dermatology Clinic, Seoul, Korea.
    Background: Recently, a biostimulatory dermal filler based on polycaprolactone (PCL) microspheres was introduced. To our knowledge, no report has examined the safety and efficacy of PCL-based dermal fillers in forehead augmentation.

    Objective: To evaluate the safety and efficacy of forehead augmentation using a PCL-based dermal filler. Read More

    An Overview of Infections Associated With Soft Tissue Facial Fillers: Identification, Prevention, and Treatment.
    J Oral Maxillofac Surg 2017 Jan 14;75(1):160-166. Epub 2016 Sep 14.
    Chief, Section of Infectious Disease, Waterbury Hospital, Waterbury; Associate Clinical Professor of Medicine, Yale University School of Medicine, New Haven, CT.
    Purpose: The purpose of this study was to provide an overview of infections associated with facial soft tissue fillers.

    Materials And Methods: A literature review was performed which evaluated infections associated with facial soft tissue fillers.

    Results: Infection rates with soft tissue fillers are low and are estimated at 0. Read More

    Correction of Age-Related Midface Volume Loss With Low-Volume Hyaluronic Acid Filler.
    JAMA Facial Plast Surg 2017 Mar;19(2):88-93
    Greene.MD Plastic Surgery & Laser Center, Weston, Florida.
    Importance: The pivotal approval trial for a smooth, highly cohesive, viscous, 20-mg/mL hyaluronic acid filler demonstrated sustained aesthetic improvement, with a mean injection volume of 6.65 mL. In daily practice, however, it is not often practical or necessary to use large injection volumes to achieve the desired cosmetic outcome. Read More

    Rejuvenation of the perioral and lip regions with two new dermal fillers: The Italian experience with Vycross(™) Technology.
    J Cosmet Laser Ther 2017 Feb 23;19(1):54-58. Epub 2016 Nov 23.
    c Plastic Surgeon , Verona , Italy.
    Background: Hyaluronic acid fillers are frequently used for maintenance of youthful appearance of perioral and lip region. The introduction of Juvederm(®) Volbella(™) with lidocaine and Juvederm(®) Volift(™) with lidocaine to the European aesthetic market in 2012 increased the options of fillers to be used and it appears to be a new solution to improve this area.

    Objective: the aim of this study is to demonstrate how to correct this area using two new dermal fillers: Juvederm(®) Volift(™) with lidocaine, and Juvederm(®) Volbella(™) with lidocaine, based on the experience of two Italian phycians. Read More

    Labia Majora Augmentation with Hyaluronic Acid Filler: Technique and Results.
    Aesthet Surg J 2016 Nov 30;36(10):1155-1163. Epub 2016 May 30.
    Dr Fasola is a microsurgeon in private practice in Milan, Italy. Dr Gazzola is a Resident, Department of Plastic Surgery, Università degli Studi di Milano, Milan, Italy.
    Background: External female genitalia lose elasticity and volume with age. In the literature several techniques address the redundancy of the labia minora, but only few reports describe the augmentation of labia majora with fat grafting. At present, no studies describe the augmentation of the labia majora with hyaluronic acid. Read More

    Delayed Adverse Subcutaneous Reaction to a New Family of Hyaluronic Acid Dermal Fillers With Clinical, Ultrasound, and Histologic Correlation.
    Dermatol Surg 2017 Apr;43(4):605-608
    Pérez & Gavín dermatólogos Clinic, Vigo, Spain Department of Radiology Department of Dermatology, Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Clinica Servet, University of Santiago de Chile, Santiago de Chile, Chile Service of Dermatology, Department of Pathology, Hospital Universitario de Salamanca Salamanca, Spain.

    An 18-Month Follow-up, Randomized Comparison of Effectiveness and Safety of Two Hyaluronic Acid Fillers for Treatment of Moderate Nasolabial Folds.
    Dermatol Surg 2017 Jan;43(1):58-65
    *RZANY & HUND, Privatpraxis, Berlin, Germany; †Department of Dermatology and Allergology, HSK Wiesbaden, Lehrkrankenhaus der Universität Mainz, Wiesbaden, Germany; ‡Department of Dermatology, Cannes Hospital, Cannes, France; §Centre dermato-chirurgical et médecine de la nutrition, Bordeaux, France; ‖Dermatologische Praxis, Wuppertal, Germany; ¶CPCAD, Hôpital l'Archet 2, Nice, France; #Gemeinschaftspraxis für Dermatologie, Mahlow, Germany; **Praxis Dr. med. Boris Sommer, Frankfurt, Germany; ††Galderma, Uppsala, Sweden; ‡‡Department of Dermatology, Klinikum Darmstadt, Darmstadt, Germany.
    Background: Hyaluronic acid (HA) filler injection is a popular nonsurgical aesthetic procedure.

    Objective: To compare the effectiveness and safety of 2 hyaluronic acid fillers (HAEC and HARES) for treatment of moderate nasolabial folds (NLFs).

    Materials And Methods: This was an evaluator- and subject-blinded split-face study. Read More

    Older women's negative psychological and physical experiences with injectable cosmetic treatments to the face.
    J Women Aging 2017 Jan-Feb;29(1):51-62. Epub 2016 Aug 11.
    b Department of Family Studies and Gerontology , Mount Saint Vincent University , Halifax , Nova Scotia , Canada.
    Seven women (43 to 64 years old) who had negative or mixed emotions about having Botox and/or facial filler injections to the face to reduce signs of aging were interviewed about the impact of the procedures. Impacts ranged from disappointment to all-encompassing, lingering physical and psychological effects, and some women felt abandoned by the medical industrial complex when they turned to it for help with their symptoms. A feminist phenomenological analysis focused on corporeal, temporal, and relational existential modes of being. Read More

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