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Molecules 2021 May 14;26(10). Epub 2021 May 14.

Ceramic Physics Laboratory, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, Kyoto 606-8585, Japan.

The present work investigated the effect of Polylactic acid (PLA) fibers produced by centrifugal spinning with incorporated BaTiO particles to improve their bacteriostatic behavior. The PLA matrix and three composites, presenting three different amounts of fillers, were subjected to UV/O treatment monitoring the possible modifications that occurred over time. The morphological and physical properties of the surfaces were characterized by different microscopic techniques, contact angle, and surface potential measurements. Read More

Int J Surg Case Rep 2021 May 26;83:106013. Epub 2021 May 26.

Departament of Oral Medicine and Prosthodontics, Faculty of Dentistry, Universidade de Passo Fundo, Passo Fundo, Brazil. Electronic address:

Introduction And Importance: Orthognathic surgery aims to restore the functional and esthetic standards of the face and non-surgical or minimally invasive procedures have been optimizing the results of facial orthosurgical treatments. This case report aimed to show the use of minimally invasive techniques that, associated with orthognathic surgery, represent a trend in current oral and maxillofacial rehabilitation.

Case Presentation: A female patient, 28 years old, white, sought care from the Dentistry team of the São Vicente de Paulo Hospital, in Passo Fundo, Brazil, complaining of mandibular prognathism, anteroposterior maxillary deficiency, dental crowding, malocclusion, functional and esthetic changes that negatively affected her psychosocial interactions and stomatognathic function. Read More

Plast Surg Nurs 2021 Apr-Jun 01;41(2):98-104

Rachel Varga, BScN, RN, CANS, is a board certified aesthetic nurse specialist, Victoria, British Columbia, Canada.

Including the jawline in aesthetic assessment has become increasingly popular when using both surgical and nonsurgical techniques. Facial aging processes include bone resorption, fat pad atrophy, and a breakdown of the quality of collagen and elastin in the skin. To provide optimal treatment of the jawline using nonsurgical techniques, it is important to consider all of these aspects before planning treatment. Read More

J Plast Reconstr Aesthet Surg 2021 Apr 22. Epub 2021 Apr 22.

Department of Plastic Surgery, Sandwell General Hospital, Lyndon, West Bromwich, West Midlands, B71 4HJ, UK.

Hyaluronidase is a family of enzymes that degrade hyaluronic acid (HA). It is found to increase vascular permeability and temporarily disrupt the extracellular matrix, promoting diffusion of substances through tissues. Alongside its applications in ophthalmology, obstetrics and gynaecology, musculoskeletal medicine, radiology and drug and fluid administration, hyaluronidase has a number of roles in the field of plastic surgery. Read More

Aesthet Surg J 2021 05;41(Suppl 1):S31-S38

Division of Dermatology, University of California San Diego, La Jolla, CA, USA.

Facial rejuvenation requires a multi-modality approach to address the sun damage, volume loss, and thinning of skin that occurs with aging. With age, the collagen fibrils that provide strength become fragmented and fibroblasts connections become weak, leading to skin laxity and loss of youthful skin. Fillers can lead to a more youthful appearance by providing volumetric support. Read More

Actas Dermosifiliogr (Engl Ed) 2021 May 10. Epub 2021 May 10.

Servicio de Radiología Intervencionista. Avda. de Córdoba s/n, 28041, Madrid, España.

Ischemic events are the most serious complications of facial antiaging treatment with dermal fillers. Ischemia can cause Nicolau syndrome, blindness, or even stroke. This article discusses how to prevent ischemic complications and what steps to take should a dermatologic emergency develop. Read More

J Cosmet Laser Ther 2021 May 9:1-2. Epub 2021 May 9.

Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.

When an adverse event occurs after a dermal filler treatment, simple ultrasound can be of help for diagnosis. But sometimes a more sophisticated imaging technique as MRI is needed to find the true reason for a complication. As in the case of pneumosinus dilatans after injection of a dermal filler, we present. Read More

J Cosmet Laser Ther 2021 May 6:1-9. Epub 2021 May 6.

Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.

As filler injections have become very common procedures worldwide, the number of complications has increased. However, there is a lack of systematized studies and precise classification of late and delayed complications. This study aimed to suggest new and reliable classifications and to characterize the clinical manifestations of late and delayed complications after filler injections. Read More

Aesthet Surg J 2021 May 4. Epub 2021 May 4.

Department of Clinical Anatomy, Mayo Clinic College of Medicine and Science, Rochester, MN.

Background: Injectable soft tissue fillers are used on a global scale for a variety of aesthetic indications. Despite their widespread use, there is a dearth of information regarding the potential repeated injections into tissue have to cause needle deformation. Repeated injections with the same needle result in an increase in force used by the injector to achieve dermal penetration, potentially resulting in decreased precision and increased patient discomfort. Read More

Transgend Health 2021 Apr 15;6(2):82-90. Epub 2021 Apr 15.

San Francisco Department of Public Health, San Francisco, California, USA.

Subcutaneous injections, or "fillers," are used illicitly and in large quantities by trans women for feminization. They are associated with severe complications, but data on their use are limited, especially in places with widespread access to safe gender-affirming care. Our analysis seeks to assess the prevalence, correlates, and complications of filler use to inform prevention and treatment. Read More

Surv Ophthalmol 2021 Apr 29. Epub 2021 Apr 29.

Corneoplastic Unit, Queen Victoria Hospital NHS Trust, East Grinstead, United Kingdom. Electronic address:

The popularity and variety of temporary and permanent periocular aesthetic treatments has increased over the past decade. Patients frequently present to eye clinics with ocular complications and side effects following these treatments, their severity ranging from ocular irritation from dry eyes to visual loss from vascular occlusion. A careful, thorough history is essential, as many patients may not associate aesthetic procedures with ocular complications, and some may be embarrassed to disclose this information. Read More

Facial Plast Surg Clin North Am 2021 May 24;29(2):359-367. Epub 2021 Apr 24.

Oculofacial Plastic Surgery, Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Dermal fillers remain popular for facial rejuvenation but with its increasing use, the potential for more complications including blindness is present. This article focuses on the mechanism of filler-associated blindness, possible treatments, and future directions. Unfortunately, to date there is no proven treatment to reverse filler-induced blindness or visual compromise. Read More

Facial Plast Surg Clin North Am 2021 May 24;29(2):349-357. Epub 2021 Apr 24.

Saint Louis University School of Medicine, St Louis, MO, USA; Ophthalmic Plastic and Cosmetic Surgery, Inc., St Louis, MO, USA. Electronic address:

Dermal fillers, in particular hyaluronic acid gel (HAG) fillers, are used in the treatment of aging changes in the periocular area. Filler treatment requires in-depth knowledge of specific issues relating to product performance and administration, safety protocols, and recognition and treatment of complications. There are different approaches to treatment of the tear trough. Read More

Facial Plast Surg Clin North Am 2021 May 24;29(2):335-348. Epub 2021 Apr 24.

University of Puerto Rico School of Medicine, Medical Sciences Campus, PO BOX 365067, San Juan, PR 00936, USA.

A retrospective observational case study and a literature review were conducted to evaluate how anatomic findings, especially those related to the periorbital zone, serve as a guiding compass for injectable implants. Treatment techniques and product selection will be discussed for patients with negative vector, shallow orbit, and deep set eyes. Versatility of injectables will be demonstrated on patients with peanut face, iatrogenically altered anatomy (after surgery), and trauma. Read More

Dermatol Surg 2021 May;47(5):645-648

All authors are affiliated with the Department of Dermatological Surgery, Cooper University Health Care, Camden, New Jersey.

Background: There is limited knowledge on the extent physicians delegate cosmetic procedures to midlevel providers.

Objective: To assess dermatology and plastic surgery practice patterns for the injections of neurotoxins and dermal fillers.

Materials And Methods: Four hundred ninety-two dermatology and plastic surgery practices were identified from 10 major US metropolitan areas. Read More

J Cosmet Dermatol 2021 Apr 26. Epub 2021 Apr 26.

Department of Facial Plastic & Facial Cosmetic Surgery, The Esthetic Clinics, Mumbai, India.

Background: Non-surgical rhinoplasty using hyaluronic acid dermal fillers is a cosmetic procedure that has been becoming increasingly popular among patients wanting to correct nasal deformities or nasal irregularities, in the recent years.

Aim: This systematic review aims to provide quality evidence about the success of non-surgical rhinoplasty procedures in terms of patient satisfaction and complications.

Methods: A systematic electronic literature search using keywords and MESH search terms over the PubMed/Medline, Cochrane Central, Scopus, and EBSCO online databases was conducted from November 2005 to February 2021. Read More

J Biol Regul Homeost Agents 2021 Mar-Apr;35(2):775-777

Maxillo-Facial Surgery, "Luigi Vanvitelli" University Hospital, Naples, Italy.

J Cosmet Dermatol 2021 Apr 20. Epub 2021 Apr 20.

Cosmetic Laser Dermatology: A West Dermatology Company, San Diego, CA, USA.

Introduction: Adverse effects from dermal fillers are uncommon. We report a case of filler-induced xanthelasma at the bilateral infraorbital region in a 43-year-old woman after multiple injections of hyaluronic acid to correct tear trough depression.

Material And Methods: We report a case of a 43-year-old woman with a chief complaint of skin discoloration of the bilateral lower eyelids. Read More

Hautarzt 2021 May 20;72(5):408-420. Epub 2021 Apr 20.

Hautzentrum Köln, Schillingsrotter Str. 39-41, 50996, Köln, Deutschland.

Injection treatments with hyaluronic acid-based fillers are a standard procedure in aesthetic medicine. Performed by an experienced and thoughtful physician, they lead to effective and natural treatment results. It is paramount to know and avoid adverse events and complications or to identify and treat them in a timely manner. Read More

Aesthetic Plast Surg 2021 Apr 19. Epub 2021 Apr 19.

R&D Research team, Inventage Lab Inc. Jungwon-gu, Seongnam, 13438, Gyeonggi, Korea.

Background: Poly-L-lactic acid (PLLA) is widely used in tissue engineering. The natural polymer hyaluronic acid (HA) shows excellent biocompatibility and affects cell signaling, proliferation, and differentiation. In addition, a polynucleotide (PN) induces cell growth of human skin fibroblasts and osteoblasts. Read More

J Drugs Dermatol 2021 Apr;20(4):451-459

Background: Requests for hand rejuvenation, in particular with nonsurgical aesthetic procedures, are increasing. Several injectable dermal fillers are currently used to restore soft tissue volume; however, the anatomic complexity of the hand and extreme mobility of its underlying tissues involve the use of specific implants and adapted injection technique. We report a case series demonstrating the efficacy, durability, and safety of a hyaluronic acid-based dermal filler (HA-filler) for hand rejuvenation. Read More

Am J Ophthalmol Case Rep 2021 Jun 18;22:101063. Epub 2021 Mar 18.

Eye Institute, Cleveland Clinic Abu Dhabi, C7-257 Swing Wing, Al Maryah Island, Abu Dhabi, 112412, United Arab Emirates.

Purpose: Over the last decade, injectable soft tissue fillers have become an essential part of facial plastic surgery practice. We report here a tragic complication of hyaluronic acid filler injection in a young healthy woman, management offered, and the outcome.

Observations: A 32-year-old woman developed unilateral acute blindness, orbital pain, total ophthalmoplegia, and anterior and posterior segment ischemia immediately following hyaluronic acid injection. Read More

Aesthet Surg J 2021 04;41(5):625-626

Associate Director of Cosmetic Surgery, University of Pennsylvania, Philadelphia, PA, USA.

Georgian Med News 2021 Feb(311):74-79

Central Research Institute of Radiation Diagnostics, Moscow, Russia.

132 women after facial contouring on terms from 2 weeks to 15 years after filler injection were examined by sonography (US). They had complaints of the edema, hypercorrection, asymmetry, discomfort and anxiety about the excess of the terms that filler had spent into the soft tissues. HA fillers were injected in 111 cases (84. Read More

J Am Pharm Assoc (2003) 2021 Mar 11. Epub 2021 Mar 11.

Background: This report presents the case of a patient who developed a nonthrombotic embolus attributed to a polyalkylimide dermal filler, and it also charts pharmacotherapeutic strategies for polyalkylimide complications reported in the literature.

Case Summary: A 31-year-old female presented to a community teaching hospital with dyspnea, hemoptysis, and fever. A thorough history revealed that the patient received intragluteal injections of a polyalkylimide dermal filler (Bio-Alcamid) 4 days before hospitalization, although it was initially and incorrectly diagnosed as silicone embolism syndrome. Read More

Polymers (Basel) 2021 Mar 19;13(6). Epub 2021 Mar 19.

UB-CARE S.r.l.-Spin-off University of Pavia, 27100 Pavia, Italy.

(1) Background: Injectable hyaluronic acid (HA) dermal fillers are used to restore volume, hydration and skin tone in aesthetic medicine. HA fillers differ from each other due to their cross-linking technologies, with the aim to increase mechanical and biological activities. One of the most recent and promising cross-linkers is polyethylene glycol diglycidyl ether (PEGDE), used by the company Matex Lab S. Read More

J Cosmet Dermatol 2021 Jun 28;20(6):1634-1642. Epub 2021 Apr 28.

Department for Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilian University Munich, Munich, Germany.

Background: A plethora of age-related changes contribute to hollowing of the temples, as bone remodeling, atrophy of the temporalis muscle, thinning of the skin, and deflation of the subcutaneous and deep temporal fat create the appearance of a skeletonized face. In addition, previous studies have established a relationship between facial skeletonization, temporal hollowing, and postmenopausal sarcopenia.

Objective: To compare the volume change, adverse events, and patient satisfaction of soft-tissue filler injections in the temple between young (<51) and old (>51) females. Read More

Clin Exp Dermatol 2021 Mar 24. Epub 2021 Mar 24.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea.

Skin necrosis is one of the most severe complications following filler injections, and can result in permanent aesthetic defects. Although an increasing number of studies have addressed the management of dermal filler complications, no study has described the spectrum of microbial pathogens. The aim of this study was to delineate the bacterial profile and prognostic factors of filler-related skin necrosis by reviewing the clinical and microbiological features of these patients. Read More

Oral Maxillofac Surg Clin North Am 2021 May 6;33(2):185-195. Epub 2021 Mar 6.

Texas A&M Oral and Maxillofacial Surgery, 3000 Gaston Avenue Dallas, TX 75226 USA.

A heightened cultural emphasis on youth and beauty has resulted in an increase in cosmetic surgery in the Western world. Lip augmentation is one of the most popular cosmetic procedures done because full lips are considered youthful and voluptuous. With reliable and improved techniques, it is possible to change the appearance of the lips utilizing injectable materials and surgical techniques. Read More

Int J Biol Macromol 2020 Dec 24;165(Pt B):2834-2844. Epub 2020 Oct 24.

Department of Organic Materials Engineering, Chungnam National University, Daejeon 34134, South Korea. Electronic address:

Hyaluronic acid (HA) is widely used as a filler owing to its excellent biocompatibility and biodegradability. However, commercial HA-based filler products have some limitations and can cause side effects due to the presence of residual chemical crosslinking agents. In this study, tyramine (Tyr) was introduced into HA to impart photocrosslinking ability to HA, and a photocrosslinked hydrogel was formed using a less toxic vitamin B2 derivative as a photoinitiator. Read More