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    Autologous Fat Transfer for Facial Rejuvenation: A Systematic Review on Technique, Efficacy, and Satisfaction.
    Plast Reconstr Surg Glob Open 2017 Dec 22;5(12):e1606. Epub 2017 Dec 22.
    Department of Plastic, Reconstructive and Hand Surgery, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Plastic, Reconstructive and Hand Surgery, VU Medical Center, Amsterdam, The Netherlands; and Department of Epidemiology & Biostatistics, VU Medical Center, Amsterdam, The Netherlands.
    Background: Parallel to the steady decline in surgical aesthetic procedures to the face, dermal fillers seem to have gained a more prominent place in facial rejuvenation over the last couple of years. As a dermal, facial filler, autologous fat transfer (AFT) seems to have real potential because of the biocompatibility of adipose tissue besides being a procedure with few and primarily minor complications. This systematic review aims to evaluate the available evidence regarding the safety and effectiveness of AFT for facial rejuvenation. Read More
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    Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers.
    Plast Reconstr Surg Glob Open 2017 Dec 22;5(12):e1532. Epub 2017 Dec 22.
    Laser and Light Cosmetic Medical Skin Clinic, Loughborough, United Kingdom.
    Objective: Even though injectable hyaluronic acid (HA)-based fillers are considered safe, rare complications, such as late-onset inflammatory reactions have been reported. Possible causes and effective treatments have not been formally described, so this work aims to discuss these and offer a formal protocol for treatment.

    Methods: This article presents 5 clinical cases of late-onset inflammatory response occurring at least 3 months after uneventful injection of HA dermal filler. Read More
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    Optimizing outcomes with polymethylmethacrylate fillers.
    J Cosmet Dermatol 2018 Mar 30. Epub 2018 Mar 30.
    Sadick Dermatology, New York, NY, USA.
    Introduction: The ideal filler should be long-lasting, biocompatible, chemically inert, soft and easy to use, and have a long history of safety. This review focuses on the evolution and development of the PMMA-collagen gel, Bellafill, and the 10 years of postmarketing experience of Bellafill since it received premarket approval (PMA) from the FDA as Artefill in 2006. Artefill was rebranded to Bellafill in 2015. Read More
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    Randomized, Patient/Evaluator-Blinded, Intraindividual Comparison Study to Evaluate the Efficacy and Safety of a Novel Hyaluronic Acid Dermal Filler in the Treatment of Nasolabial Folds.
    Dermatol Surg 2018 Apr;44(4):542-548
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
    Background: Comparative research on the characteristics of filler products is limited, especially in the preclinical analysis of hyaluronic acid (HA) fillers.

    Objective: This study was performed to compare the preclinical characteristics, clinical efficacy, and safety of a new HA filler, IDHF-001, with Restylane SubQ in the treatment of nasolabial folds (NLFs).

    Methods: Viscoelasticity and injection force were evaluated. Read More
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    Late Presentation of Infected Silicone Granulomas in the Lower Limb.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 22;11:1179544118759020. Epub 2018 Feb 22.
    Department of Pathology, Royal Free Hospital, London, UK.
    Introduction: Dermal fillers are used for multiple cosmetic indications including gluteal and thigh augmentation. Complications, although infrequent, are increasing due to the dramatic growth of dermal filler use. Our aim was to describe how the complication of infected silicone granulomas can present following lower limb augmentation. Read More
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    Hyperbaric Oxygen for Ischemia due to Injection of Cosmetic Fillers: Case Report and Issues.
    Plast Reconstr Surg Glob Open 2018 Jan 11;6(1):e1618. Epub 2018 Jan 11.
    Division of Plastic & Reconstructive Surgery, University of Nebraska Medical Center, Omaha, Neb.; and Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Neb.
    Natural and synthetic fillers have revolutionized aesthetic facial rejuvenation and soft-tissue augmentation. We present a case highlighting the dangers of filler self-injection. A 37-year-old woman self-injected a dermal filler around both temples. Read More
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    [Facial injections of hyaluronic acid-based fillers for malformations. Preliminary study regarding scar tissue improvement and cosmetic betterment].
    Ann Chir Plast Esthet 2018 Feb 2. Epub 2018 Feb 2.
    Service de chirurgie maxillo-faciale et chirurgie plastique, hôpital universitaire Necker-enfants-malades, centre de référence fentes et malformations faciales, 149, rue de Sèvres, 75015 Paris, France; Faculté de médecine Paris-Descartes, université Paris 5, 75006 Paris, France.
    Background: Cross-linked hyaluronic acid-based fillers have gained rapid acceptance for treating facial wrinkles, deep tissue folds and sunken areas due to aging. This study evaluates, in addition to space-filling properties, their effects on softness and elasticity as a secondary effect, following injection of 3 commercially available cross-linked hyaluronic acid-based fillers (15mg/mL, 17,5mg/mL and 20mg/mL) in patients presenting with congenital or acquired facial malformations.

    Patients Et Methods: We started injecting gels of cross-linked hyaluronic acid-based fillers in those cases in 2013; we performed 46 sessions of injections in 32 patients, aged from 13-32. Read More
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    An innovative method to quantitate tissue integration of hyaluronic acid-based dermal fillers.
    Skin Res Technol 2018 Feb 2. Epub 2018 Feb 2.
    Galderma R&D, Sophia Antipolis, France.
    Background/purpose: Following intradermal injection, hyaluronic acid (HA)-based fillers tend to spread within the reticular dermis and to distribute between the dermal fibers. This biointegration is commonly measured qualitatively using histological methods. We developed a "toolbox" consisting of a visual scoring and a semi-automatic image analysis method using internal developed algorithm to quantitate the biointegration of Restylane® in histological sections. Read More
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    Gold Nanoparticle-Collagen Gels for Soft Tissue Augmentation.
    Tissue Eng Part A 2018 Mar 20. Epub 2018 Mar 20.
    1 Department of Bioengineering, College of Engineering, University of Missouri , Columbia, Missouri.
    Collagen soft tissue fillers suffer from fast reabsorption, which minimizes their use as a tissue-engineered construct. Extensive cross-linking can be utilized to extend longevity, but changes in microstructure and biomechanics can have deleterious effects. To enhance longevity while still achieving a natural microstructure, gold nanoparticles (AuNPs) were conjugated to fibrilized collagen and homogenized into an injectable form for use as a soft tissue filler. Read More
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    High-frequency ultrasound-based differentiation between nodular dermal filler deposits and foreign body granulomas.
    Skin Res Technol 2018 Jan 23. Epub 2018 Jan 23.
    Life-Beauty, Grodzisk Mazowiecki, Poland.
    Background: The number of procedures involving dermal filler injection is still on the rise. Although their safety is improving, not all complications can be avoided. The late complications manifesting as nodules or granulomas pose a particular diagnostic and therapeutic challenge, due to the lack of uniform standards or guidelines. Read More
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    Mild Complications or Unusual Persistence of Porcine Collagen and Hyaluronic Acid Gel Following Periocular Filler Injections.
    Ophthal Plast Reconstr Surg 2018 Jan 9. Epub 2018 Jan 9.
    David G. Cogan Ophthalmic Pathology Laboratory, and Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology of the Massachusetts Eye and Ear Infirmary and the Harvard Medical School, Boston, Massachusetts, U.S.A.
    The purpose of this study was to describe the histopathologic appearance of dermal eyelid fillers that were unexpectedly encountered in ophthalmic plastic surgery samples from patients with mild eyelid disfigurements, and to review eyelid cases with complications that had previously been described in the literature. A retrospective histopathologic study with Alcian blue, elastic, and Masson trichrome stains of 2 cases that were submitted to the Ocular Pathology Department was conducted, and a critical review of previously published cases of the histopathologic characteristics of dermal filler material in the periocular region was also conducted. Two periocular tissue samples were found to contain dermal filler material. Read More
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    Cohesive Polydensified Matrix Hyaluronic Acid for the Treatment of Etched-In Fine Facial Lines: A 6-Month, Open-Label Clinical Trial.
    Dermatol Surg 2018 Jan 8. Epub 2018 Jan 8.
    Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.
    Background: Available hyaluronic acid dermal fillers have unique biophysical properties that influence their clinical utility, longevity, and aesthetic outcomes.

    Objective: To evaluate the effectiveness and durability of a cohesive polydensified matrix hyaluronic acid dermal filler (CPM-HA) for the treatment of etched-in fine facial lines.

    Materials And Methods: Subjects with etched-in fine lines of the forehead, cutaneous lip, melolabial folds, nasolabial folds, and/or radial cheek received treatment with CPM-HA mixed with lidocaine and epinephrine, with an optional touch-up treatment at Week 2, if deemed necessary. Read More
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    Role of Nonsurgical Chin Augmentation in Full Face Rejuvenation: A Review and Our Experience.
    Dermatol Surg 2018 Jan 5. Epub 2018 Jan 5.
    Cosmetic Laser Dermatology, San Diego, California.
    Background: The chin is a critical component to the perception of facial attractiveness. Dermal fillers offer a nonsurgical, temporary method of correcting mild to moderate chin retrusion and resorption. Thus far, discussion of this procedure has been largely limited to the plastic surgery and otolaryngology literature. Read More
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    Treatment of Soft Tissue Filler Complications: Expert Consensus Recommendations.
    Aesthetic Plast Surg 2018 Apr 5;42(2):498-510. Epub 2018 Jan 5.
    Clínica de Medicina Estética Dra Villanueva, Carrer de Calvet 10, Barcelona, Spain.
    Background: Dermal fillers have been increasingly used in minimally invasive facial esthetic procedures. This widespread use has led to a rise in reports of associated complications. The aim of this expert consensus report is to describe potential adverse events associated with dermal fillers and to provide guidance on their treatment and avoidance. Read More
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    Fluorodeoxyglucose activity associated with a cosmetic poly-L-lactide filler: a potential confounder on positron emission tomography and computed tomography.
    Br J Oral Maxillofac Surg 2018 Feb 28;56(2):148-150. Epub 2017 Dec 28.
    Department of Radiology and Nuclear Medicine, Oxford University Hospital NHS Foundation Trust. Electronic address:
    Injectable cosmetic fillers are increasingly popular, but are not often considered as a cause of abnormal findings on imaging. We present a case of poly-L-lactic acid (PLLA) filler associated with 18-fluorodeoxyglucose (FDG) uptake, which had the potential to interfere with staging of a squamous cell carcinoma of the lateral tongue. We characterise the FDG-positron emission tomography/computed tomography (PET/CT) properties of a PLLA dermal filler, Sculptra (Aventis), and highlight its potentially confounding appearance in the staging scans of oncological patients, particularly those with oral tumours. Read More
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    Magnetic resonance imaging appearance of foreign-body granulomatous reactions to dermal cosmetic fillers.
    Imaging Sci Dent 2017 Dec 12;47(4):281-284. Epub 2017 Dec 12.
    Division of General Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
    Foreign body granulomas can develop after the injection of various cosmetic filling materials into the facial area to flatten wrinkles. Clinically, reactive lesions are easily mistaken for soft-tissue neoplasms or cysts. This report presents a case of foreign body granuloma in a 52-year-old female patient complaining of a painless swelling in the nasolabial region. Read More
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    A Cross-sectional Analysis of Adverse Events and Litigation for Injectable Fillers.
    JAMA Facial Plast Surg 2017 Dec 21. Epub 2017 Dec 21.
    Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan.
    Importance: Injectable fillers are increasing in popularity as a noninvasive option to address concerns related to facial aging and volume loss. To our knowledge, there have been no large-scale analyses of adverse events and associated litigation related to filler injections.

    Objectives: To determine risks of injectable fillers and analyze factors raised in litigation related to injectable fillers. Read More
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    Non-surgical minimally invasive rhinoplasty: tips and tricks from the perspective of a dermatologist.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):101-103
    Department of Dermatology, School of Medicine, Ufuk University, Ankara, Turkey.
    Introduction: Rhinoplasty is one of the most common aesthetic procedures performed by plastic surgeons all over the world. In recent years, a non-surgical nose job has become the preferred option for most patients and specialists. Minimally invasive techniques already result in high satisfaction rates. Read More
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    Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature.
    Immunol Res 2018 Feb;66(1):120-140
    Europe Medical Centre, Barcelona, Spain.
    Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and methacrylate compounds in a Spanish patient cohort. This study is a retrospective analysis of clinical, laboratory, histopathological and follow-up data of 45 cases of patients suffering from late-onset, non-infectious inflammatory/autoimmune disorders related to bioimplants. Read More
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    The PET-CT Radiological Appearance of Facial Cosmetic Injections: A Pitfall in the Evaluation of the Oncological Patient.
    Isr Med Assoc J 2017 Nov;19(11):679-681
    Rheumatology Unit, Sheba Medical Center, Tel Hashomer, Israel.
    Background: Facial rejuvenation using different dermal and sub-dermal injectable compounds is a popular cosmetic procedure which may pose a diagnostic dilemma to the radiologist.

    Objectives: To describe the appearance of cosmetic facial fillers on PET-CT.

    Methods: All PET-CT exams performed between January 2015 and May 2017 in which findings suggestive of prior facial filler procedures was evident and where anamnestic confirmation with the patient was possible were reviewed. Read More
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    Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé).
    Clin Cosmet Investig Dermatol 2017 8;10:431-440. Epub 2017 Nov 8.
    Behavior, Paris, France.
    Background: The range of fillers currently available for soft-tissue augmentation is constantly expanding. The latest advances in filler technology include collagen biostimulators that exert their esthetic effect by promoting neocollagenesis. One such product is the next-generation collagen biostimulator (Ellansé) that demonstrates properties as yet unseen in soft-tissue fillers. Read More
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    Hybrid Complexes of High and Low Molecular Weight Hyaluronans Highly Enhance HASCs Differentiation: Implication for Facial Bioremodelling.
    Cell Physiol Biochem 2017 27;44(3):1078-1092. Epub 2017 Nov 27.
    Background/aims: Adipose-derived Stem Cells (ASCs) are used in Regenerative Medicine, including fat grafting, recovery from local tissue ischemia and scar remodeling. The aim of this study was to evaluate hyaluronan based gel effects on ASCs differentiation and proliferation.

    Methods: Comparative analyses using high (H) and low (L) molecular weight hyaluronans (HA), hyaluronan hybrid cooperative complexes (HCCs), and high and medium cross-linked hyaluronan based dermal fillers were performed. Read More
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    Non-aesthetic indications for periocular hyaluronic acid filler treatment: a review.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Corneo-plastic Unit, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, United Kingdom.
    Dermal fillers have been in use for many years for aesthetic rejuvenation of the face. More recently, however, fillers have been increasingly used as an alternative to traditional surgical procedures for non-aesthetic indications. These indications include lagophthalmos, eyelid malpositions and orbital volume deficiency. Read More
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    Comparing Efficacy and Costs of Four Facial Fillers in Human Immunodeficiency Virus-Associated Lipodystrophy: A Clinical Trial.
    Plast Reconstr Surg 2018 Mar;141(3):613-623
    Madrid, Spain From the Department of Plastic Surgery, University Hospital Gregorio Marañón.
    Background: The objective of this study was to evaluate and compare the safety and effectiveness of four different dermal fillers in the treatment of facial lipoatrophy secondary to human immunodeficiency virus.

    Methods: The authors conducted a clinical trial including 147 patients suffering from human immunodeficiency virus-induced lipoatrophy treated with Sculptra (poly-L-lactic acid), Radiesse (calcium hydroxylapatite), Aquamid (polyacrylamide), or autologous fat. Objective and subjective changes were evaluated during a 24-month follow-up. Read More
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    A Novel and More Aesthetic Injection Pattern for Malar Cheek Volume Restoration.
    Aesthetic Plast Surg 2018 Feb 24;42(1):197-200. Epub 2017 Oct 24.
    Galderma Laboratories, L.P, 14501 N. Freeway Rd, Fort Worth, TX, 76177, USA.
    The loss of superior midface contour and projection can be corrected with the use of injectable hyaluronic acid (HA) dermal fillers, however, the most frequently used injection pattern employs a technique which was originally designed for malar implant surgery. Here we describe a novel injection pattern for restoring facial contours with a HA dermal filler inspired by traditional make-up artistry, which includes greater superolateral positioning of injection sites. Importantly, this technique helps injectors avoid creating an excess of volume in the anterior portion of the malar complex. Read More
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    Hyaluronic Acid Gel With (HARRL) and Without Lidocaine (HAJU) for the Treatment of Moderate-to-Severe Nasolabial Folds: A Randomized, Evaluator-Blinded, Phase III Study.
    Dermatol Surg 2018 Apr;44(4):549-556
    Galderma Laboratories, L.P., Fort Worth, Texas.
    Background: Hyaluronic acid (HA) dermal fillers are frequently used to correct or smooth facial wrinkles and folds such as nasolabial folds.

    Objective: To compare the efficacy and safety of 2 HA gels, formulated by 2 different manufacturing processes: XpresHAn Technology (HARRL [with lidocaine]) and Hylacross technology (HAJU-a comparator product without lidocaine).

    Patients And Methods: One hundred seventy subjects with bilateral nasolabial folds rated as moderate or severe, according to the Wrinkle Severity Rating Scale (WSRS), received injections of HARRL in the nasolabial folds on one side of the face and HAJU on the other side. Read More
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    [Body experience and self-esteem after minimally invasive skin rejuvenation : Study of female patients using botulinum toxin A and/or dermal fillers].
    Hautarzt 2017 Dec;68(12):959-967
    , Leipziger Str. 44, 39120, Magdeburg, Deutschland.
    Background: More and more people worldwide and also in Germany are using botulinum toxin type A (BoNT-A) and hyaluronic acid injections for skin rejuvenation.

    Objective: Study on body image and self-esteem of women with BoNT-A and/or hyaluronic acid filler treatment.

    Material And Methods: A total of 145 women who requested BoNT-A and/or hyaluronic acid injections completed a survey comprised of the body dysmorphic disorder questionnaire, the Rosenberg self-esteem scale and questionnaires on the attitudes and motives on measures for optimization of the body and demographic features. Read More
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    The Efficacy of Vibration Anesthesia on Reducing Pain Levels During Lip Augmentation: Worth the Buzz?
    Aesthet Surg J 2017 10;37(9):1044-1048
    Koç University School of Medicine, Istanbul, Turkey.
    Background: Lip augmentation procedures have increased drastically in the last years as patients seek to enhance the shape and size of their lips with dermal fillers. One of the main concerns faced with these procedures is the pain inflicted through injections. On the other hand, many different techniques have been introduced for the reduction of pain while performing office-based minimal invasive procedures. Read More
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    Hyaluronic acid gel filler for nipple enhancement following breast reconstruction.
    Cutis 2017 Aug;100(2):107-109
    Galderma Laboratories, LP, Fort Worth, Texas, USA.
    The loss of the 3-dimensional contour of the nipple-areola complex (NAC) following surgical breast reconstruction is a technical challenge for the physician and a psychological burden for many breast cancer patients. The use of injectable dermal fillers to enhance nipple projection is a simple noninvasive procedure with immediate and adjustable volume results that positively impact patient satisfaction. The utility and safety of injectable hyaluronic acid (HA) gel make it an ideal filler for restoring the natural feel and contour to the delicate structure of the NAC and in some cases may represent a simple solution following breast reconstruction. Read More
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    U.S. Food and Drug Administration Authors Publish Articles on Dermal Filler Materials, Injections, Methods, and Skin Preparation.
    Plast Reconstr Surg 2017 10;140(4):632e-633e
    U.S. Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry and Materials Science, Laboratory of Microbiology and Infection Control, Washington, D.C.
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    [Forehead rejuvenation].
    Ann Chir Plast Esthet 2017 Oct 22;62(5):406-423. Epub 2017 Sep 22.
    50, rue de la République, 69002 Lyon, France. Electronic address:
    The goal of this article is to provide a systemic approach to forehead rejuvenation. Fillers, botulinic toxin injections, transpalpebral, endoscopic or bicoronal brow lift must be usual techniques for every plastic surgeon in overall facial rejuvenation. Achieving a long lasting and aesthetically pleasing forehead is possible only with surgical techniques when aging is obvious. Read More
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    Surgeon's Guide to Facial Soft Tissue Filler Injections: Relevant Anatomy and Safety Considerations.
    J Oral Maxillofac Surg 2017 Dec 24;75(12):2667.e1-2667.e5. Epub 2017 Aug 24.
    Resident, Oral and Maxillofacial Radiology, School of Dental Medicine, University of Connecticut, Farmington, CT.
    The purpose of this study is to provide a review of the relevant facial anatomy related to soft tissue filler injections. Facial fillers are used daily in our clinical practice. Although their use is safe and predictable, adverse events do occur. Read More
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    Lifting the Lower Face With an Absorbable Polydioxanone (PDO) Thread.
    J Drugs Dermatol 2017 Sep;16(9):932-934
    Traditional rejuvenation techniques include chemical peels, rhytidectomy of the skin, laser resurfacing, injection of dermal fillers and neurotoxins, and invasive surgical procedures. Patients with brow ptosis, jowl formation, and deepening nasolabial folds currently seek antiaging procedures with no incisions and minimal downtime such as thread-lifting with barbed sutures. The present report describes a case in which polydioxanone threads were used to lift the lower third of a patient's face. Read More
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    Factors Affecting the Rheological Measurement of Hyaluronic Acid Gel Fillers.
    J Drugs Dermatol 2017 Sep;16(9):876-882
    Background: With the number of available dermal fillers increasing, so is the demand for scientifically based comparisons, often with rheological properties in focus. Since analytical results are always influenced by instrument settings, consensus on settings is essential to make comparison of results from different investigators more useful.

    Objective: Preferred measurement settings for rheological analysis of hyaluronic acid (HA) fillers are suggested, and the reasoning behind the choices is presented by demonstrating the effect of different measurement settings on select commercial HA fillers. Read More
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    Precision in Dermal Filling: A Comparison Between Needle and Cannula When Using Soft Tissue Fillers.
    J Drugs Dermatol 2017 Sep;16(9):866-872
    Background: Precise implantation of soft tissue fillers to treat the signs of aging is crucial for patient safety and the best aesthetic outcome. Injections are performed commonly with either needles or cannulas, but quantitative comparative data on precise implantation are still elusive.

    Methods: Ten fresh-frozen cephalic foreheads (9 male, 1 female) were injected with radiopaque material using both needles and cannulas. Read More
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    Atypical Facial Filler Granuloma: Comparative Histologic Analysis with Paraffinoma.
    Arch Craniofac Surg 2016 Sep 23;17(3):169-172. Epub 2016 Sep 23.
    Department of Plastic and Reconstructive Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
    Dermal fillers are generally accepted as safe and well-tolerable cosmetic tools. However, adverse reactions have been reported in the literature. Here, we present a case of atypical facial filler granuloma and compare its histologic features with those of the classic paraffinoma. Read More
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    [Benefits of volumetric to facial rejuvenation. Part 2: Dermal fillers].
    Ann Chir Plast Esthet 2017 Oct 12;62(5):550-559. Epub 2017 Sep 12.
    Hôpital américain de Paris, 63, boulevard Victor-Hugo, 92200 Neuilly-sur-Seine, France; 90, boulevard Flandrin, 75116 Paris, France.
    Injectable substances known as fillers are used to palliate age-related atrophy and ptosis, and for their so-called "pseudo-lifting" action. They do not replace face and neck lift, but allow it to be postponed or, when injected after surgical lifting, make the result durable. Hyaluronic acid has a predominant and unchallenged place among fillers, well ahead of poly-L-lactic acid or calcium hydroxyapatite. Read More
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    Small-Particle Hyaluronic Acid Gel Treatment of Photoaged Hands.
    Dermatol Surg 2018 Jan;44(1):68-74
    Skin Laser & Surgery Specialists of New York and New Jersey, Hackensack, New Jersey.
    Background: Aging hands tend to lose subcutaneous volume resulting in prominence of the underlying vessels, tendons, and bone contributing to an aged appearance. Dermal fillers have been successfully used to improve the appearance of the aging dorsal hand.

    Objective: The objective is to evaluate the safety and efficacy of a small-particle hyaluronic acid (SPHA) injectable gel for the treatment of photoaged volume loss of the hands. Read More
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    Hyaluronic acid-hydroxyapatite nanocomposite hydrogels for enhanced biophysical and biological performance in a dermal matrix.
    J Biomed Mater Res A 2017 Dec 19;105(12):3315-3325. Epub 2017 Sep 19.
    Department of Materials Science and Engineering, Seoul National University, Seoul, South Korea.
    A hyaluronic acid (HAc)-hydroxyapatite (HAp) nanocomposite (HAc-nanoHAp) hydrogel was fabricated through an in situ precipitation process for mechanical and biological enhancement as a soft tissue augmentation product. In this study, these composite hydrogel fillers were analyzed from three different perspectives and compared with pure HAc hydrogel for soft tissue augmentation application: (1) rheological behaviors, (2) in vivo lateral diffusion under mouse skin, and (3) wrinkle improvement in a photo-aged mouse model. HAc-nanoHAp provided great improvement to wrinkles because of its higher stiffness and gel cohesiveness in comparison with that of pure HAc. Read More
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    Facial Soft Tissue Augmentation in Males: An Anatomical and Practical Approach.
    Dermatol Surg 2017 Nov;43 Suppl 2:S131-S139
    *Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; †Department of Dermatology, Weill Cornell Medicine, New York, New York; ‡Department of Dermatology, UCLA Medical Center, Los Angeles, California; §Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
    Background: Soft tissue augmentation is increasingly being performed to treat male facial aging.

    Objective: To review anatomical consideration specific for the male face and define an approach to male soft tissue augmentation that creates harmonious and natural results.

    Conclusion: Addressing aesthetic concerns in the upper face, midface, and lower face should be performed in concert with a combinatorial and pan facial approach. Read More
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    A Prospective, Open-Label Study of Hyaluronic Acid-Based Filler With Lidocaine (VYC-15L) Treatment for the Correction of Infraorbital Skin Depressions.
    Dermatol Surg 2017 Oct;43(10):1271-1280
    *Centre Chirurgical Niforos, Lyon, France; †The Gatehouse, Cheshire, United Kingdom; ‡SkinConcept, Munich, Germany; §La Jouvence, Neuchâtel, Switzerland; ‖Private Practice, Milan, Italy; ¶Peloton Advantage, Parsippany, New Jersey; #Allergan Plc, Marlow, United Kingdom.
    Background: Infraorbital skin depressions are one of the most troublesome facial areas for aesthetically aware patients.

    Objective: Evaluate effectiveness and safety of Juvéderm Volbella with Lidocaine (VYC-15L; Allergan plc, Dublin, Ireland) for correction of bilateral infraorbital depressions.

    Methods: In this 12-month, prospective, uncontrolled, open-label study, subjects aged ≥18 years with infraorbital depressions rated ≥1 on the Allergan Infra-oRbital Scale (AIRS) received injections of VYC-15L with optional touch-up treatment on Day 14. Read More
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    Hyaluronidase: Understanding Its Properties and Clinical Application for Cosmetic Injection Adverse Events.
    Plast Surg Nurs 2017 Jul/Sep;37(3):109-111
    Jeanine Harrison, BScN, MN, RN-EC, NP, is Nurse Practitioner, TH Medical Aesthetics, Thornhill, Ontario, Canada. Oriol Rhodes RN, BAS, MBA, is Registered Nurse, TH Medical Aesthetics, Thornhill, Ontario, Canada.
    The recent global consensus on the management of cosmetic aesthetic injectable complications from hyaluronic acid (HA) has increased the focus on the use of hyaluronidase more than ever before (M. Signorini et al., 2016). Read More
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    Assessment of the Efficacy and Safety of Hyaluronic Acid Gel Injection in the Restoration of Fullness of the Upper Lips.
    J Cutan Aesthet Surg 2017 Apr-Jun;10(2):101-105
    Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
    Background And Aim: Lips have a significant role in face aesthetic perception, and lip augmentation is one of the most commonly requested aesthetic procedures. Non-permanent dermal fillers, such as hyaluronic acid (HA), are used for augmenting the lips. This article presents the results of Phase II, before - after designed study, assessing the safety and efficacy of a soft tissue HA filler, for upper lip augmentation. Read More
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    Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Lower Face.
    Plast Reconstr Surg 2017 Sep;140(3):393e-404e
    São Paulo, Brazil; Singapore; South Yarra, Melbourne, Victoria, Australia; and Birmingham, Ala. From the Clinica Dr. Maurício de Maio; the Woffles Wu Aesthetic Surgery and Laser Centre; the Dermatology Institute of Victoria; and the Total Skin and Beauty Dermatology Center.
    This third article of a three-part series addresses techniques and recommendations for aesthetic treatment of the lower face. The lower face is considered an advanced area for facial aesthetic treatment. In this region, soft-tissue fillers play a more important role than neuromodulators and should be used first to provide structure and support before neuromodulators are considered for treatment of dynamic lines. Read More
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    Dermal filler-associated malar edema: Treatment of a persistent adverse effect.
    Orbit 2017 Dec 24;36(6):473-475. Epub 2017 Aug 24.
    a Department of Ophthalmology , Palmetto Health University of South Carolina Medical Group , Columbia , South Carolina , USA.
    A 72-year-old Caucasian female presented for evaluation of bilateral lower eyelid "fluid filled" bags that had been present and slowly worsening for 7 years. She reported a history of lower eyelid blepharoplasty in her 40s, as well as hyaluronic acid tear trough fillers 8 years prior to presentation. Her malar edema completely resolved following injection of hyaluronidase. Read More
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