Search Our Scientific Publications & Authors

F1000Res 2018 3;7:1388. Epub 2018 Sep 3.

Department of Plastic and Reconstructive Surgery, University of Catania, Catania, 95100, Italy.

Injection of dermal fillers, like hyaluronic acid (HA), is a safe procedure, with few and transient side effects such as erythema, bruising and swelling etc. The aim of this report is to provide our protocol for the early treatment of necrotic complications after facial treatment with dermal fillers. We present two cases of skin suffering of the face after dermal infiltration of HA, treated successfully with our early protocol. Read More

J Cosmet Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.

Background: Numerous fillers are increasingly used for augmentation of volume loss and relaxation of facial wrinkles. Collagen stimulators are the latest next-generation dermal fillers that can induce neocollagenesis. To investigate biophysical characteristics, safety, and efficacy of newly developed polydioxanone (PDO) filler in comparison with poly-l lactic acid (PLLA) and polycaprolactone (PCL) fillers. Read More

J Cosmet Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Dermatology, Imam Muhammad ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Objective: This review is primarily focusing on the legitimate concern about bacterial contamination after reuse of stored filling syringes and its associated risk of infections.

Methods: A comprehensive literature review was done through searching the PubMed, Medline, Google Scholar, and ResearchGate without setting a time limit. The following search terms were used soft tissue filler, hyaluronic acid, or calcium hydroxylapatite AND sterility, safety, retouch, touch up, or reuse. Read More

Polymers (Basel) 2018 Jul 13;10(7). Epub 2018 Jul 13.

Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Korea.

The number of breast reconstruction surgeries has been increasing due to the increase in mastectomies. Surgical implants (the standard polydimethylsiloxane (PDMS) implants) are widely used to reconstruct breast tissues, however, it can cause problems such as adverse immune reactions, fibrosis, rupture, and additional surgery. Hence, polymeric fillers have recently garnered increasing attention as strong alternatives for breast reconstruction materials. Read More

Otolaryngol Clin North Am 2019 Apr 4. Epub 2019 Apr 4.

PLLC Plastic & Reconstructive Surgery, 969 Park Ave Suite 1G New York, NY 10028, USA; Georgetown University, Washington, DC, USA.

Minimally invasive procedures including neurotoxins, dermal fillers, deoxycholic acid, lasers, peels, and microneedling offer powerful, less permanent adjuncts to surgery that are highly effective in select patients. Injectables and skin resurfacing techniques target facial irregularities including wrinkles and fine lines, decrease in volume and contour, and unwanted fat. Determining the best approach for a given patient involves careful consideration of the patient's health conditions, unique anatomic characteristics, tissue quality, and desired results. Read More

Otolaryngol Clin North Am 2019 Apr 4. Epub 2019 Apr 4.

PLLC Plastic & Reconstructive Surgery, 969 Park Avenue, New York, NY 10028, USA; Georgetown University, Washington, DC, USA.

Surgical techniques for cosmetic facial rejuvenation, antiaging concerns, and the optimization of facial beauty can be nuanced and complex. Generally speaking, surgical interventions, including facelift, necklift, blepharoplasty, and rhinoplasty, are the gold standard approaches for the enhancement of facial features. A detailed understanding of facial anatomy, aesthetics, and techniques is necessary to master these approaches. Read More

Aesthetic Plast Surg 2019 Apr 5. Epub 2019 Apr 5.

Centro Médico Kineergomed, Linares, Chile.

Background: The perception of an attractive face is largely subjective. The purpose of this paper is to provide an insight and a practical approach to facial contouring management with hyaluronic acid (HA) implants and botulinum toxin A.

Methods: This study is presenting the clinical experience of the authors regarding facial contouring. Read More

Facial Plast Surg 2019 Apr 3;35(2):140-148. Epub 2019 Apr 3.

David and Rossi Cosmetic Surgery, La Jolla, CA, USA.

The shape of the jawline from the mandibular angle to its most forward point at the chin has a profound effect on an individual's appearance and is an area of concern for many seeking esthetic procedures. Dermal filler injections alone or in combination with other modalities, such as skin tightening energy devices, allow enhancement of the jawline while avoiding the need for surgical procedures. The authors introduce new anatomical zones and nomenclature to enhance safety and outcome when enhancing the jawline. Read More

Ugeskr Laeger 2019 Mar;181(12)

Injections of dermal fillers are commonly performed procedures. The usage of dermal fillers is expanding worldwide, and many serious complications have been reported. This review focuses on the various types of complications and the relevant treatment of these complications. Read More

Dermatol Surg 2019 Mar 25. Epub 2019 Mar 25.

Cosmetic Laser Dermatology, San Diego, California.

Background: More than 90% of women have reported concerns of cellulite on their skin. Both commercially advertised creams and topical pharmacological agents have shown limited improvement. Thus far, there has been a paucity of thorough review articles on how to address and treat this condition. Read More

Biomed Opt Express 2019 Mar 19;10(3):1315-1328. Epub 2019 Feb 19.

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

We present a system for automatic determination of the intradermal volume of hydrogels based on optical coherence tomography (OCT) and deep learning. Volumetric image data was acquired using a custom-built OCT prototype that employs an akinetic swept laser at ~1310 nm with a bandwidth of 87 nm, providing an axial resolution of ~6.5 μm in tissue. Read More

J Cosmet Dermatol 2019 Feb 26. Epub 2019 Feb 26.

Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: The popularity of dermal fillers has grown rapidly in the last few years for facial rejuvenation. Plasma gel is an autologous gelatinous material that is prepared from the patient's own platelet poor plasma.

Objective: To evaluate the clinical efficacy and safety of plasma gel injection as a dermal filler for facial rejuvenation. Read More

Clin Exp Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Treatment options for atrophic acne scars include the use of various energy-based devices (EBDs) and dermal fillers.

Aim: To evaluate the level of improvement and safety of four treatments for atrophic acne scars used in our centre.

Methods: We reviewed the medical records of all patients with acne scars treated between 2013 and 2016 with one of four treatments: ablative fractional CO laser (FACL), a radiofrequency (RF) bipolar device, a 1540 nm nonablative fractional laser (NAFL) and injection of diluted calcium hydroxylapatite (CaHA). Read More

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

Allergan plc, Irvine, California.

Background: Individuals with skin of color are underrepresented in studies of lip and perioral enhancement.

Objective: To examine the effectiveness and safety of hyaluronic acid (HA) dermal filler treatment for lip and perioral enhancement in subjects with skin of color.

Methods: Data were pooled from subjects with Fitzpatrick skin phototypes IV, V, or VI in 2 pivotal studies of HA dermal fillers. Read More

Aesthet Surg J 2019 Feb 19. Epub 2019 Feb 19.

Private practice in Seoul, Korea.

Background: During aging, facial skin thins, atrophies, and loses elasticity. Subdermal filler injections can volumize and treat wrinkles but cannot directly change dermal thickness. Polycaprolactone (PCL)-fillers can improve skin texture and quality through dermal thickening and inducing neocollagenesis. Read More

Toxicol Ind Health 2019 Mar 13;35(3):189-195. Epub 2019 Feb 13.

1,1,1,3,3,3-Hexamethyldisilazane (HMDZ) is used industrially to treat the surface of silica, as an intermediate adhesion promoter or silylating agent in the semiconductor industry, as a chemical modifier of inorganic fillers, and as a water scavenger silicone sealant. In animal studies, HMDZ is considered to be slightly to at most moderately toxic following acute administration via oral, dermal, and inhalation routes of exposure. HMDZ is neither an eye irritant nor was it dermally irritating under semiocclusive conditions; however, it caused dermal necrosis in two studies under occlusive conditions. Read More

J Am Acad Dermatol 2019 Mar;80(3):591-602

Department of Dermatology, Kaiser Permanente, San Francisco, California.

Lesbian, gay, bisexual, and transgender (LGBT) persons face important health issues relevant to dermatologists. Men who have sex with men (MSM) are at higher risk of certain infectious diseases, including HIV, syphilis and other sexually transmitted diseases (STDs), methicillin-resistant Staphylococcus aureus infections, and invasive meningococcal disease, and might be at higher risk of non-infectious conditions, including skin cancer. Recommendations for preventive health care, including screening for HIV and other STDs, sexual health-related vaccinations, and HIV pre-exposure prophylaxis, differ for MSM compared with non-MSM. Read More

J Cosmet Dermatol 2019 Jan 31. Epub 2019 Jan 31.

TLC Lifestyle Practice, Scotts Medical Center at Pacific Plaza, Singapore City, Singapore.

A handheld 2 MHz ultrasound Doppler device determines the presence or absence of pulsatile arterial flow immediately beneath the selected site of entry for dermal filler injection. In combination with near infrared technology to map out superficial veins, mishaps from intravascular injections may be reduced. A total of 448 patients aged range between 21 and 74 years, with 168 out of total of 1019 treatment sites having both infrared and ultrasound Doppler assisted preinjection mapping were reviewed. Read More

J Drugs Dermatol 2019 01;18(1):86-91

Background: Calcium hydroxylapatite (CaHA, Radiesse®) with integral 0.3% lidocaine (CaHA(+)) has recently been approved for use in aesthetic medicine. This study assessed the performance of CaHA(+) in subjects undergoing treatment for facial volume loss and evaluated subject and physician satisfaction. Read More

J Drugs Dermatol 2019 01;18(1):67-74

Objective: To study the safety, efficacy, optimal volume, and longevity of an injectable hyaluronic acid (HA) gel dermal filler to treat facial temporal fossa fat loss. Methods and materials: This open-label, single-site, 12-month study used 20 mg/mL HA gel to correct volume loss in both temples in 30 subjects. Touch-ups were allowed at week 2. Read More

Dermatology 2019 16;235(2):156-163. Epub 2019 Jan 16.

Área de Anatomía y Embriología Humana, Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain.

Objective: Dermal fillers are an important tool in the field of aesthetic dermatology. Fillers are relatively noninvasive and easy to use but are not free of secondary complications. The main complications are vascular and are due to either the compression of an artery or the direct introduction of the product into the arterial lumen. Read More

Aesthet Surg J 2019 Jan 14. Epub 2019 Jan 14.

Department of Maxillofacial Plastic Surgery, Division of Dental and Maxillofacial Surgery and the Department of Public Health and Community Medicine, Unit of Epidemiology and Medical Statistics, G.B. Rossi Hospital and Medical University of Verona, Verona, Italy.

Background: The bad outcomes of a facial trauma could have a strongly negative psychological impact and compromise patient's quality of life. Unfortunately, surgery cannot always solve this problem or give an acceptable result.

Objectives: Aesthetic medicine treatments with injectables may provide a solution that is minimally invasive and more accepted by the patients in improving bad outcomes after facial trauma. Read More

Plast Reconstr Surg 2019 03;143(3):659e-660e

Department of Plastic, Oral, and Maxillofacial Surgery, Teikyo University School of Medicine, Tokyo, Japan Department of Plastic Surgery, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan Department of Plastic, Oral and Maxillofacial Surgery, Teikyo University School of Medicine, Tokyo, Japan.

Plast Reconstr Surg 2019 03;143(3):659e

Division of Plastic Surgery and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic, Jacksonville, Fla. Plastic and Reconstructive Surgery Unit, Santa Maria alle Scotte Hospital, University of Siena, Siena, Italy Division of Plastic Surgery and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic, Jacksonville, Fla.

Plast Reconstr Surg 2019 01;143(1):98-101

Dallas, Texas; and Miami, Fla. From the Dallas Plastic Surgery Institute; and the Institute of Aesthetic Medicine.

Much of facial aging can be attributed to volume deflation and tissue laxity. Successful surgical rejuvenation can be achieved through volume restoration with autologous fat grafting of the facial fat compartments. In conjunction with volume restoration, correction of tissue laxity and recontouring of the face and neck can be achieved. Read More

Plast Reconstr Surg 2019 01;143(1):53-63

Albany and New York, N.Y.; Sacramento, Calif.; Munich, Germany; Zurich, Switzerland; and Salzburg, Austria From the Department of Medical Education, Albany Medical College; private practice; Facial Plastic and Reconstructive Surgery, University of California, Davis Medical Center; the Department for Hand, Plastic and Aesthetic Surgery, Ludwig Maximilian University; the Division of Thoracic Surgery, University Hospital Zurich; and the Department of Radiology, Paracelsus Medical University Salzburg & Nuremberg.

Background: Injection of soft-tissue fillers into the facial fat compartments is frequently performed to ameliorate the signs of facial aging. This study was designed to investigate the functional anatomy of the deep facial fat compartments and to provide information on the effects of injected material in relation to age and gender differences.

Methods: Forty fresh frozen cephalic specimens of 17 male and 23 female Caucasian body donors (mean age, 76. Read More

Br Dent J 2018 Dec;225(12):1049

Dermatol Surg 2019 Apr;45(4):552-556

Maryland Dermatology, Laser, Skin and Vein Institute, Hunt Valley, Maryland.

Background: Hyaluronic acid fillers (HAFs) and energy-based devices are frequently used sequentially. However, the effect of using fractional devices directly over HAF is unclear.

Objective: To evaluate histologic changes after fractional laser and radiofrequency (RF) therapies applied over preinjected HAF. Read More

J Am Acad Dermatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pharmaceutical Science, State University of Ponta Grossa, Brazil.

Trials 2018 Dec 17;19(1):689. Epub 2018 Dec 17.

Department of Radiation Oncology, Erasmus MC Cancer Institute, PO Box 5201, 3008 AE, Rotterdam, The Netherlands.

Background: Accelerated partial breast irradiation (APBI) is a treatment option for selected early stage breast cancer patients. Some APBI techniques lead to skin toxicity with the skin dose as main risk factor. We hypothesize that a spacer injected between the skin and target volume reduces the skin dose and subsequent toxicity in permanent breast seed implant (PBSI) patients. Read More

Clin Cosmet Investig Dermatol 2018 23;11:603-611. Epub 2018 Nov 23.

Institute of Medical and Biomedical Education, St George's University of London, London, UK.

The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures. Read More

Plast Reconstr Surg Glob Open 2018 Oct 2;6(10):e1909. Epub 2018 Oct 2.

CHAO Institute of Aesthetic Medicine, Taipei, Taiwan.

A 3-dimensional, multi-layered approach combining modalities targeting different manifestations is recommended for achieving optimal esthetic outcomes. To date, studies reporting same-day treatment with dermal fillers and botulinum toxin have not been published. This article documents the practical use of a single-visit, pan-facial multimodal approach in addressing the varying esthetic needs of 8 Asian adults. Read More

Plast Reconstr Surg 2019 02;143(2):428-439

Verona, Italy; and Malvern and Melbourne, Victoria, Australia From the Division of Dental and Maxillofacial Surgery, "G. B. Rossi Hospital" and Medical University of Verona; Erase Esthetic Services; and Me clinic.

Background: Nonsurgical rhinoplasty using injectable fillers improved skin quality and texture, cost-effectiveness, and quick recovery. The aim of this study was to provide a valid and customized protocol for injecting the nose with the aid of a nasal grid.

Methods: From January of 2015 to October of 2018, 150 consecutive patients entered the trial. Read More

J Drugs Dermatol 2018 11;17(11):1245-1246

Introduction: Google Search is an important tool for patients researching skin care treatments and finding dermatologists. Data from individual patient’s searches are aggregated by Google and yield powerful data sets that can be used to trend population behaviors. This study investigates the correlations between the volume of Google searches and the number of procedures performed annually for both botulinum toxin type A and hyaluronic acid tissue fillers. Read More

J Drugs Dermatol 2018 11;17(11):1184 -1185

Bruising after dermal filler and neuromodulator injections is a common side effect and can have durations of 1 to 2 weeks. While it ultimately resolves, faster resolution can produce better outcomes for patients and also make patients more likely to return for future treatments. We report the successful reduction in bruising following injections of fillers with an intense pulsed light source. Read More

Med Devices (Auckl) 2018 15;11:367-376. Epub 2018 Oct 15.

Scientific Department, Skin Tech Pharma Group, Castello D'Empúries, Cataluña, Spain,

Background: Hyaluronic acid (HA), a naturally occurring polysaccharide, is used in the production of dermal fillers for esthetic purposes. As it has a few days of half-life in human tissues, HA-based dermal filler is chemically modified to increase its lifetime in the body. The most common modification used in commercial HA-based filler is the cross-linking of HA chains using 1,4-butanediol diglycidyl ether (BDDE) as cross-linking agent. Read More

Prim Care 2018 Dec;45(4):705-717

Department of Family Medicine, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address:

Plastic surgery is a broad field, including maxillofacial surgery, reconstruction after injuries, hand surgery, and skin flaps and grafts, but the most common procedures for women are liposuction and body contouring, breast surgery, and facial cosmetic procedures. Techniques of face and brow lifts, blepharoplasty, and rhinoplasty are discussed as well as botulinum toxin and filler injections, and laser and pulsed light techniques that may delay or eliminate the need for surgery. Comparison of the surgeries for breast reconstruction, reduction, augmentation, and mastopexy is discussed. Read More

J Cosmet Laser Ther 2018 Nov - Dec;20(7-8):424-435. Epub 2018 Nov 5.

b Residente de tercer año , Universidad del Rosario , Bogota , Columbia.

Background And Objectives: Acne scarring is a widely prevalent condition that can have a negative impact on a patient's quality of life and is often worsened by aging. A number of options are available for the treatment of acne scarring, including retinoids, microdermabrasion, dermal fillers, and surgical techniques such as subcision. The aim of this review is to evaluate the different laser modalities that have been used in peer-reviewed clinical studies for treatment of atrophic acne scars, and summarize current clinical approaches. Read More

Dermatol Ther 2018 11 5;31(6):e12721. Epub 2018 Nov 5.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea.

Fillers have become popular worldwide as the demand for enhancements in rejuvenating effects and esthetic improvements is continually increasing. With broader applications and the increasing number of cosmetic procedures using fillers, more filler-related complications are being reported. These filler-related complications range from mild bruising to severe vascular complications. Read More

Dermatol Surg 2018 11;44 Suppl 1:S60-S62

Directory of Dermatology, Aesthetx, Campbell, California Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Department of Dermatology, University of California, Los Angeles, California.

Dermatol Surg 2018 11;44 Suppl 1:S56-S60

Dermatology Division, Policlinica Geral do Rio de Janeiro (PGRJ), Rio de Janiero, Brazil Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Dermatology Department, Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericordia do Rio de Janeiro, Rio de Janeiro, Brazil Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.

Dermatol Surg 2018 11;44 Suppl 1:S53-S56

Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.

Dermatol Surg 2018 11;44 Suppl 1:S32-S41

Department of Plastic Surgery, Lenox Hill Hospital, New York, New York.

Background: Calcium hydroxylapatite (CaHA) is approved to correct moderate-to-severe wrinkles and folds and soft-tissue volume loss in the face and hands. More recently, subdermal injection using diluted CaHA has been used to improve skin laxity.

Objective: To review evidence for the safe and effective use of diluted CaHA in the face and body and provide best practice recommendations. Read More

Dermatol Surg 2018 11;44 Suppl 1:S10-S18

Galderma Aesthetics, Uppsala, Sweden.

Background: Acne scarring affects most patients with acne and have a negative impact on quality of life. New effective treatment options offering minimal downtime are therefore needed.

Objective: To evaluate improvement in overall facial appearance after hyaluronic acid (HA) treatment of atrophic acne scars. Read More

Dermatol Surg 2018 11;44 Suppl 1:S5-S9

Modern Dermatology, Westport, Connecticut.

Background: A dissolving agent for calcium hydroxylapatite (CaHA, Radiesse) soft-tissue filler would be of value should inadvertent intravascular injection, vascular compromise, nodule formation, or overcorrection occur.

Methods: In a prospective, single-center, proof-of-concept study, 12 cadaveric porcine skin samples were injected with CaHA (0.4-0. Read More

Dermatol Surg 2018 11;44 Suppl 1:S2-S4

Department of Dermatology, Carruthers Dermatology Centre, Vancouver, British Columbia, Canada.

Background: Worldwide, the brow is the most common facial site to receive aesthetic treatment. However, the forehead above the brows has been comparatively less well studied with respect to both neuromodulators and fillers. Age-related remodeling of the forehead with loss of facial bone has been demonstrated on detailed radiographic studies. Read More

Dermatol Surg 2018 11;44 Suppl 1:S1

Carruthers & Humphrey Cosmetic Dermatology and.

Open Access Maced J Med Sci 2018 Sep 23;6(9):1636-1641. Epub 2018 Sep 23.

Städtisches Klinikum Dresden, Academic Teaching Hospital Dresden, Department of Dermatology and Allergology, Dresden, Germany.

Background: Dermal fillers are widely used for facial and body contouring. Polymethylmethacrylate (PMMA) is a permanent biphasic filler for soft tissue augmentation. In case of unwanted side effects, drug therapy and surgical excision have been commonly used with mixed results. Read More

J Plast Reconstr Aesthet Surg 2019 Jan 27;72(1):131-136. Epub 2018 Sep 27.

Department of Plastic and Reconstructive Surgery, University Hospital Nice, Pasteur 2, 30, avenue de la Voie Romaine, 06000 Nice, France.

Background: Over the past decade, cosmetic injections of dermal fillers or fat have become a popular procedure in facial rejuvenation in an overconsuming society. However, complications such as arterial embolism and occlusion can occur even with experienced injectors, especially in high-risks zones namely the glabella, the nasal dorsum or the nasolabial fold. The aim of this study was to define the vascular danger zones of the infraorbital area in order to provide guidelines helping avoid them. Read More

J Cosmet Dermatol 2018 Oct;17(5):736-743

Private practice, Mulhouse, France.

Sound knowledge of the rheology of hyaluronic acids is fundamental for facial rejuvenation procedures. Hyaluronic acid implants are subjected to complex mechanical forces within the facial tissues that vary depending on the anatomical region. Analysis of these forces is important to establish the rheological specifications of hyaluronic acid implants in each specific zone. Read More