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Materials (Basel) 2022 Jun 9;15(12). Epub 2022 Jun 9.

Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.

Commercially available hyaluronic acid dermal fillers used as a scaffold in regenerative endodontic procedures (REPs) have demonstrated attractive potentials. This study aimed to histologically evaluate the outcome of REPs using Restylane Lyft (HA) as a scaffold. REPs were performed on pulpless, immature roots in dogs ( = 69). Read More

Dent Clin North Am 2022 Jul 31;66(3):431-442. Epub 2022 May 31.

Medical Spa, Tehran, Iran.

Just as priceless procedure of art and science needs the visual frame to bring out the subtle proportion to your face and bring out the best frame for the smile. Lip augmentation procedures with hyaluronic acid dermal fillers have become increasingly popular worldwide because full lips are often considered beautiful and youthful. The objective of a lip augmentation procedure is to create smooth lips with adequate volume and a natural appearance and not to be over corrected. Read More

J Cosmet Dermatol 2022 Jun 19. Epub 2022 Jun 19.

Dermatologist, 2 Rue de Lisbonne, 75008, Paris, France.

Background: Age-related changes of facial soft tissue cause clinical signs of facial ageing such as lip atrophy, marionette lines and an accentuated nasolabial fold. These changes can be modified using dermal fillers.

Aims: To evaluate efficacy, longevity and safety of a cross-linked hyaluronic acid- based filler with Tri-Hyal technology in the treatment of lips, nasolabial folds and marionette lines. Read More

Aesthetic Plast Surg 2022 Jun 14. Epub 2022 Jun 14.

Department of Ultrasonography, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Dr Shijingshan District, Beijing, 100144, China.

Background: Various dermal fillers are often used for nasolabial groove filling. High-frequency ultrasonography might be a valuable tool for assessing facial filler materials.

Methods: The facial ultrasound images of plastic surgery hospital of the Chinese Academy of Medical Sciences from November 2014 to November 2021 were analyzed and judged. Read More

Macromol Biosci 2022 Jun 13:e2200081. Epub 2022 Jun 13.

Department of Plastic and Reconstructive Surgery, Seoul National University Boramae Hospital, Seoul National University College of Medicine, 5 Gil 20, Boramae-Road, Dongjak-Gu, Seoul, 07061, Republic of Korea.

Currently, dermal fillers are largely based on commercialized cross-linked hyaluronic acid (HA) injections, which require a large injection force. Additionally, HA can be easily decomposed by enzymes, and HA-treated tissues present a risk of developing granuloma. In this study, a chitosan-based dermal filler is presented that operates on a liquid-to-gel transition and allows the injection force to be kept ≈4. Read More

Facial Plast Surg 2022 Apr 12;38(2):95. Epub 2022 Jun 12.

Unit of Maxillo-Facial Surgery, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.

Biomed Res Int 2022 26;2022:3790546. Epub 2022 May 26.

Department of Anatomy, Yonsei University Medical College, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea.

A hollow temple may give rise to a false impression of early facial aging. This is corrected with dermal fillers that are injected into the hollow temple area to produce a smoother facial contour. However, various complications of this procedure have been reported, with the most common being the inadvertent injection of the filler material into the superficial temporal artery (STA). Read More

Actas Dermosifiliogr 2022 Jun 2. Epub 2022 Jun 2.

Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, España; AG BIOMEDIC CLINIC, Madrid, España. Electronic address:

SARS-CoV-2 has caused millions of infections and deaths worldwide and case numbers continue to rise. Besides the effect of the virus on key organs - leading to respiratory illness, anosmia, diarrhea, and fever and other complications - delayed inflammatory reactions to hyaluronic acid dermal fillers, mainly in the face, have also been reported to occur after confirmed SARS-CoV-2 infections and in vaccinated individuals. While delayed inflammatory reactions tend to be self-limiting, they should be diagnosed and treated with corticosteroids, hyaluronidase, and/or antibiotics when necessary. Read More

Dermatol Surg 2022 Jun 22;48(6):695-696. Epub 2022 Mar 22.

Department of Dermatology, University of California, Irvine, Irvine, California.

Int J Anal Chem 2022 23;2022:4565260. Epub 2022 May 23.

Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu 730050, China.

The common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position. In order to achieve the relatively long-term antiwrinkle effect, a kind of cross-linked and non-cross-linked compound hyaluronic acid microne was prepared. By inserting the microne under the skin, dissolving the non-cross-linked part under the skin and introducing the cross-linked gel particles under the skin, the effect of extending the microne was achieved. Read More

J Clin Aesthet Dermatol 2022 May;15(5):47-58

Dr. Fabi is with the University of California, San Diego and Cosmetic Laser Dermatology in San Diego, California.

Background: Patients pursue cosmetic procedures to improve physical appearance as well as self-esteem and confidence, which translates into better quality of life. As aesthetic providers, it is important to understand the improvement in quality of life that can be achieved from various aesthetic procedures, best measured by patient reported outcomes (PROs), such as the validated FACE-Q.

Objective: This review summarizes FACE-Q outcomes after nonsurgical dermatological facial cosmetic procedures. Read More

Cureus 2022 Apr 25;14(4):e24461. Epub 2022 Apr 25.

Dermatology, Academy of Aesthetic Medicine, Sheffield, GBR.

Hyaluronic acid dermal fillers are a very popular choice for patients wanting to undergo non-invasive facial rejuvenation. Its prevalence is predicted to continue to rise. We report a case of delayed angioedema and associated urticaria to hyaluronic acid dermal fillers post COVID-19 infection. Read More

Gels 2022 May 23;8(5). Epub 2022 May 23.

Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35131 Padova, Italy.

Fillers based on crosslinked hyaluronic acid (HA) are becoming increasingly important in the field of aesthetic medicine, for example for treating wrinkles or for volumizing purposes. However, crosslinking agents are usually associated with toxicity and adverse reactions. The aim of this study is the development of an innovative technology to manufacture high performance HA-based fillers using minimal amounts of crosslinking agent. Read More

Gels 2022 Apr 23;8(5). Epub 2022 Apr 23.

UB-CARE S.r.l. Spin-Off University of Pavia, 27100 Pavia, Italy.

(1) Background: Dermal fillers are commonly used in aesthetic practice and their rheological characterization is of much interest today, as well as the stability study of the finished formula against external stimuli of a different nature (biological and physicochemical). Rheological tools have been exploited to characterize the physiochemical behaviour of a hyaluronic acid (HA) based dermal filler subjected to different thermal conditions over time. The collected results provide an index of its rheological stability. Read More

J Cosmet Dermatol 2022 May 27. Epub 2022 May 27.

Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands.

Background: Adverse events (AE) after COVID-19 vaccines, particularly, but not solely, with those messenger RNA (mRNA)-based vaccines, have rarely been reported in patients previously treated with dermal fillers (DF).

Objective: To evaluate the morphology, clinical characteristics, the timing of presentation, and outcomes of inflammatory AE appeared in patients injected with DF, after anti-COVID-19 vaccination.

Methods: Descriptive study of a case series of 20 consecutive patients collected after the occurrence of AE in previously filled areas post COVID-19 vaccination. Read More

Dermatol Surg 2022 May 17. Epub 2022 May 17.

All authors are affiliated with the Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Delayed-onset reactions are increasingly relevant given the growing use of hyaluronic acid dermal fillers. There is poor understanding of the phenomenon's etiology and incidence.

Objective: To highlight differences between the dermal filler products with an emphasis on delayed-onset reaction incidence, pathogenesis, prevention, and treatment. Read More

JAAD Case Rep 2022 Jun 14;24:35-37. Epub 2022 Apr 14.

Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Linkou, Taiwan.

J Taibah Univ Med Sci 2022 Apr 4;17(2):320-325. Epub 2021 Sep 4.

Department of Oral & Maxillofacial Surgery, Faculdade São Leopoldo Mandic, Campinas, Brazil.

Orthognathic surgery has an undeniable functional effect, but the aesthetic result must not be disregarded, especially since many patients visit the surgeon precisely because of an aesthetic complaint and ignore the practical benefits. The aim of this paper is to discuss about an ideal treatment that combines this functional improvement with facial aesthetics and improves it after the operation. In order to predict which aesthetic deficits may occur, a facial analysis is essential. Read More

Aesthetic Plast Surg 2022 May 17. Epub 2022 May 17.

ENT Surgeon, Department of Oto-Rhino-Laryngology Head and Neck Surgery, La Conception University Hospital, CNRS, IUSTI, APHM, Aix-Marseille Univ, 147 Bd Baille, 13005, Marseille, France.

Background: Nasal valve disorders frequently give rise to nasal obstruction. Dermal fillers could be used in the internal valve area to generate valve widening. The goal of this study was to report our "liquid spreader" procedure consisting in the injection of hyaluronic acid (HA) at the internal nasal valve in patients complaining of nasal obstruction. Read More

J Drugs Dermatol 2022 May;21(5):481-487

Background: Soft tissue augmentation with calcium hydroxylapatite (CaHA) is a versatile technique for line filling, skin tightening, lifting, contouring, and volumizing. The present study was designed to confirm safety and effectiveness of the product with lidocaine (CaHA (+)) in a holistic treatment of nasolabial folds (NLFs), marionette lines, and/or cheeks.

Methods: A total of 207 subjects with moderate to severe facial volume deficit were treated with CaHA(+) in this open-label study. Read More

Int J Dermatol 2022 Apr 29. Epub 2022 Apr 29.

Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Science with Interest Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Dermal fillers have become one of the main tools for soft tissue augmentation in the field of cosmetic dermatology. There are many types of fillers. While hyaluronic acid fillers are generally accepted as ones that fill in a space, they and other materials have been shown to have a biostimulatory effect on tissue through the process of a controlled foreign body reaction. Read More

J Cosmet Dermatol 2022 Jun 10;21(6):2374-2378. Epub 2022 May 10.

Department of Dermatology, Beijing ChuiYangLiu Hospital, Beijing, China.

Background: Botulinum toxin and hyaluronic acid (HA) filler injections are popular minimally invasive cosmetic procedures owing to their convenience, efficiency, and durability; however, adverse reactions often occur.

Materials And Methods: We describe the delayed hypersensitivity reaction that occurred after sequential injections of botulinum toxin and HA filler.

Results: The histopathologic and dermatoscopic findings suggested a delayed hypersensitivity reaction with the formation of a dermal foreign body granuloma. Read More

Aesthet Surg J 2022 May;42(6):NP438-NP439

Division of Plastic Surgery, University of California San Diego, San Diego, CA, USA.

J Cosmet Dermatol 2022 Jun 13;21(6):2379-2386. Epub 2022 May 13.

Pacific Derm, The Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Data suggest that hyaluronic acid (HA) fillers using VYC technology have a higher incidence of delayed-onset nodule development at facial injection sites than earlier HA products.

Objective: To assess the incidence of delayed-onset nodules with VYC products based on a single experienced injector.

Methods And Materials: Patients with delayed-onset nodules after injections with VYC-20L, VYC-17. Read More

J Cosmet Dermatol 2022 Apr 22. Epub 2022 Apr 22.

Department of Oculoplastic and Orbital Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Background: Treatment with hyaluronic acid (HA) fillers as a strategy for rejuvenation has experienced a significant growth in recent years, accompanied by a parallel increase in its complications, the treatment of which, such as hyaluronidase, we must be aware of.

Patients/methods: 14 patients (28 eyes) had indication for upper blepharoplasty surgery in the Hospital Universitario y Politécnico La Fe. After surgery, periocular skin of one eye of each patient was infiltrated with 300 U of hyaluronidase (14 cases) while the skin of the fellow eye was preserved untreated (14 controls). Read More

Clin Cosmet Investig Dermatol 2022 15;15:691-701. Epub 2022 Apr 15.

Department of Dermatology, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Northwest University, Xi'an, 710069, People's Republic of China.

Background: Hyaluronic acid (HA)-based fillers are applied to treat facial wrinkles and volume loss. Many efforts have been made to improve properties of HA to prolong the duration in aesthetic indications. A new cross-linking technique called "Tri-Hyal", could make HAs to achieve desired rheological characteristics. Read More

Gels 2022 Apr 6;8(4). Epub 2022 Apr 6.

i+Med S. Coop. Parque Tecnológico de Álava, Albert Einstein 15, Nave 15, 01510 Vitoria-Gasteiz, Spain.

Hyaluronic acid (HA) injectable biomaterials are currently applied in numerous biomedical areas, beyond their use as dermal fillers. However, bacterial infections and painful inflammations are associated with healthcare complications that can appear after injection, restricting their applicability. Fortunately, HA injectable hydrogels can also serve as drug delivery platforms for the controlled release of bioactive agents with a critical role in the control of certain diseases. Read More

Aesthet Surg J 2022 May;42(6):656-659

Bull Natl Res Cent 2022 11;46(1):97. Epub 2022 Apr 11.

Department of Oral Pathology, Faculty of Health Sciences, University of the Witwatersrand, WITS, Private Bag 3, Johannesburg, 2050 South Africa.

Background: Cosmetic dermal fillers are a sought-after procedure globally. However, despite the safety claims of filler materials by the manufacturers, adverse reactions still occur.

Case Presentation: This case report is of a 66-year-old female who presented with a late-onset complication of a hyaluronic acid dermal filler that clinically mimicked a salivary gland neoplasm. Read More

Dermatol Surg 2022 Jun 12;48(6):659-663. Epub 2022 Apr 12.

Cosmetic Laser Dermatology, A West Dermatology Company, San Diego, California.

Background: Vascular occlusions that threaten skin integrity, although not an emergency like those that threaten a patient's vision, is an urgent situation. Accurately interpreting physical examination findings is paramount. The use of high-dose, pulsed hyaluronidase is the mainstay of therapy; however, adjunctive measures that may optimize clearance of an occlusion and/or skin barrier repair such as the use of image guidance and hyperbaric oxygen should be considered. Read More