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    1 OF 14

    Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report.
    Aesthetic Plast Surg 2017 Apr 14. Epub 2017 Apr 14.
    Clínica de Medicina Estética Dra Villanueva, Carrer de Calvet 10, Barcelona, Spain.
    Background: The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid these complications. Indeed, a well-trained physician can also minimize the impact of such problems when they do occur. Read More

    Granulomatous reaction to Belotero Balance: A case study.
    J Cosmet Laser Ther 2017 Feb 28:1-3. Epub 2017 Feb 28.
    b Department of Dermatology , University of California, Irvine , Irvine , CA , USA.
    Objective: The most commonly used dermal fillers are hyaluronic acids (HAs), and in general, are well tolerated with mild to moderate risk of adverse events. The most frequently reported side effects are injection site erythema and bruising. We present the first case of a patient who developed a severe granulomatous foreign body reaction to the HA filler, Belotero Balance. Read More

    Injections through skin colonized with Staphylococcus aureus biofilm introduce contamination despite standard antimicrobial preparation procedures.
    Sci Rep 2017 Mar 23;7:45070. Epub 2017 Mar 23.
    United States Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry and Materials Science, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA.
    While surgical site preparation has been extensively studied, there is little information about resistance of skin microbiota in the biofilm form to antimicrobial decontamination, and there are no quantitative models to study how biofilm might be transferred into sterile tissue/implant materials during injections for joint spine and tendon, aspiration biopsies and dermal fillers (DF). In this work, we develop two in vitro models to simulate the process of skin preparation and DF injection using pig skin and SimSkin (silicone) materials, respectively. Using the pig skin model, we tested three of the most common skin preparation wipes (alcohol, chlorhexidine and povidone iodine) and found that during wiping they reduced the biofilm bacterial burden of S. Read More

    The Sterility of Partially Used Hyaluronic Acid Fillers After Long Storage.
    Dermatol Surg 2017 Mar 21. Epub 2017 Mar 21.
    Departments of *Dermatology, and †Microbiology, King Saud University, Riyadh, Saudi Arabia.
    Background: Hyaluronic acid (HA) gel fillers represent most soft tissue augmentation procedures currently used, because they have lower rates of complications compared with other materials. Many patients do not consume an entire syringe of filler but may require a retouch or intermittent augmentation after some time. The remaining material is commonly stored in a specific environment for reuse by the same patient. Read More

    Hyaluronic Acid Fillers in Soft Tissue Regeneration.
    Facial Plast Surg 2017 Feb 22;33(1):87-96. Epub 2017 Feb 22.
    Department of Life Science and Biotechnology, Universita degli Studi di Ferrara Dipartimento di Scienze della Vita e Biotecnologie, Ferrara, Emilia-Romagna, Italy.
    Over the last years, hyaluronic acid (HA) injectable dermal fillers (DFs) have become the most popular agents for soft tissue contouring and volumizing. HA fillers are characterized by most of the properties that an ideal DF should have, due to HA unique chemical-physical properties, biocompatibility, biodegradability, and versatility. Therefore, HA DFs have revolutionized the filler market with a high number of products, which differ in terms of HA source, cross-linkage (agent and degree), HA concentration, hardness, cohesivity, consistency, inclusion or lack of anesthetic, indication, and longevity of correction. Read More

    Safety and Effectiveness of Juvéderm Ultra Plus Injectable Gel in Correcting Severe Nasolabial Folds in Chinese Subjects.
    Plast Reconstr Surg Glob Open 2017 Jan 16;5(1):e1133. Epub 2017 Jan 16.
    Peking University Third Hospital, Beijing, China (D.L.); Shanghai 9th People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (Y.X., Qingfeng Li); General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guang Dong, China (Qin Li); Union Hospital of Tongji Medical College of HUST, Wuhan, Hubei, China (J.S.); Nanfang Hospital, Southern Medical University, Guangzhou, China (P.J.); Allergan China, Beijing, China (Y.J.); and Allergan plc, Irvine, Calif., (D.K.M.).
    Background: Hyaluronic acid dermal fillers are effective in correcting severe nasolabial folds (NLFs) in non-Asian populations. We assessed safety and effectiveness of Juvéderm Ultra Plus in a Chinese population.

    Methods: This double-blind study randomized Chinese subjects with severe NLFs to Juvéderm Ultra Plus (24 mg/mL) in 1 NLF and Restylane injectable gel (20 mg/mL) in the other NLF. Read More

    A Prospective, Open-Label, Observational, Postmarket Study Evaluating VYC-17.5L for the Correction of Moderate to Severe Nasolabial Folds Over 12 Months.
    Dermatol Surg 2017 Feb;43(2):238-245
    *Rosenpark Research, Darmstadt, Germany;†Cologne Dermatology, Köln, Germany;‡Elzen Kliniek, Noord-Holland, Netherlands;§Allergan, Ltd., Marlow, United Kingdom (former Allergan employees);‖Allergan plc, Irvine, California;¶Allergan plc, Marlow, United Kingdom.
    Background: VYC-17.5L (17.5 mg/mL hyaluronic acid, 0. Read More

    Outcome of Dermal Grafting in the Management of Atrophic Facial Scars.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):244-248
    Department of Dermatology, Venereology and Leprology, Bengaluru Medical College and Research Institute, Bengaluru, Karnataka, India.
    Background: Scars over the face are cosmetically and psychologically disturbing. Various techniques have been described and are being practiced in the management of these scars.

    Aims And Objectives: This study was undertaken to study the safety, effectiveness of using dermal grafts as fillers in the management of facial scars due to acne, chickenpox, trauma or any others. Read More

    Facial Contouring With Fillers, Neuromodulators, and Lipolysis to Achieve a Natural Look in Patients With Facial Fullness.
    J Drugs Dermatol 2016 Dec;15(12):1536-1542
    Background: The desire for and use of nonsurgical injectable esthetic facial treatments is on a rise in Asia. Recent advances, including more versatile facial fillers, refined injection techniques, and adoption of a global facial approach, have in turn contributed to improved patient outcomes and increased patient satisfaction. The sought after nonsurgical treatments include the use of botulinum toxin, con- touring of the face with soft tissue fillers, and thinning of the face with injection lipolysis. Read More

    [Hyaluronic acid rheology: Basics and clinical applications in facial rejuvenation].
    Ann Chir Plast Esthet 2017 Jan 6. Epub 2017 Jan 6.
    Service de chirurgie maxillofaciale et de chirurgie plastique, réparatrice et esthétique, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
    Hyaluronic acid (HA) is the most widely used dermal filler to treat facial volume deficits and winkles specially for facial rejuvenation. Depending on various areas of the face, filler is exposed to two different forces (shear deformation and compression/stretching forces) resulting from intrinsec and external mechanical stress. The purpose of this technical note is to explain how rheology, which is the study of the flow and deformation of matter under strains, can be used in our clinical practice of facial volumization with fillers. Read More

    Efficacy and safety of new dermal fillers.
    Cutis 2016 Nov;98(5):309-313
    Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Many dermal fillers are available for various cosmetic rejuvenation purposes including but not limited to treatment of facial rhytides, nasolabial folds (NLFs), facial volume deficits, and lipoatrophy; facial contouring; and lip and/or cheek augmentation. To update clinicians on best practices, we review the efficacy and safety data on the most recently approved dermal fillers. Read More

    Current concepts in lip augmentation.
    Cutis 2016 Nov;98(5):325-329
    Weill Cornell Medical College, New York, New York, USA.
    Facial rejuvenation, particularly lip augmentation, has gained widespread popularity. An appreciation of perioral anatomy as well as the structural characteristics that define the aging face is critical to achieve optimal patient outcomes. Although techniques and technology evolve continuously, hyaluronic acid (HA) dermal fillers continue to dominate aesthetic practice. Read More

    The Facial Adipose Tissue: A Revision.
    Facial Plast Surg 2016 Dec 29;32(6):671-682. Epub 2016 Dec 29.
    Department of Anatomy, Ross University School of Medicine, Roseau, West Indies.
    Recent advantages in the anatomical understanding of the face have turned the focus toward the subcutaneous and deep facial fat compartments. During facial aging, these fat-filled compartments undergo substantial changes along with other structures in the face. Soft tissue filler and fat grafting are valid methods to fight the signs of facial aging, but little is known about their precise effect on the facial fat. Read More

    The Efficacy and Safety of HA IDF Plus (with Lidocaine) Versus HA IDF (Without Lidocaine) in Nasolabial Folds Injection: A Randomized, Multicenter, Double-Blind, Split-Face Study.
    Aesthetic Plast Surg 2017 Apr 28;41(2):422-428. Epub 2016 Dec 28.
    Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14584, Republic of Korea.
    Background: Injection-related pain of dermal fillers is a consistent and bothersome problem for patients undergoing soft tissue augmentation. Reducing the pain could improve overall patient satisfaction.

    Objective: The purpose of this study was to compare the pain relief, efficacy, and safety of HA IDF plus containing lidocaine with HA IDF without lidocaine during correction of nasolabial folds (NLFs). Read More

    Ocular Pain and Impending Blindness During Facial Cosmetic Injections: Is Your Office Prepared?
    Aesthetic Plast Surg 2017 Feb 28;41(1):199-203. Epub 2016 Dec 28.
    Division of Plastic Surgery, Voluntary Clinical Faculty, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
    Soft tissue filler injections are the second most common non-surgical procedure performed by the plastic surgeon. Embolization of intravascular material after facial injection is a rare but terrifying outcome due to the high likelihood of long-term sequela such as blindness and cerebrovascular accident. The literature is replete with examples of permanent blindness caused by injection with autologous fat, soft tissue fillers such as hyaluronic acid, PLLA, calcium hydroxyl-apatite, and even corticosteroid suspensions. Read More

    Disparities in Aesthetic Procedures Performed by Plastic Surgery Residents.
    Aesthet Surg J 2017 May;37(5):582-587
    From the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
    Background: Operative experience in aesthetic surgery is an important issue affecting plastic surgery residents.

    Objectives: This study addresses the variability of aesthetic surgery experience during plastic surgery residency.

    Methods: National operative case logs of chief residents in independent/combined and integrated plastic surgery residency programs were analyzed (2011-2015). Read More

    Comparison of Intra-arterial and Subcutaneous Testicular Hyaluronidase Injection Treatments and the Vascular Complications of Hyaluronic Acid Filler.
    Dermatol Surg 2017 Feb;43(2):246-254
    *State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R.China; †Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China; ‡National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
    Background: Hyaluronidase is a key preventative treatment against vascular complications of hyaluronic acid (HA) filler injection, but the degradation profile of HA to hyaluronidase is limited, and the comparison between intra-arterial and subcutaneous injections of hyaluronidase has not been studied.

    Objective: To evaluate HA degradation to hyaluronidase and compare different treatments between intra-arterial and subcutaneous testicular hyaluronidase injections.

    Materials And Methods: The authors observed HA degradation to hyaluronidase in vitro via microscopic examination and particle analysis. Read More

    Late-Onset Complication of Fillers: Paraffinoma of the Lower Eyelids Clinically Mimicking Xanthelasma.
    Ann Dermatol 2016 Dec 23;28(6):753-756. Epub 2016 Nov 23.
    Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
    Injectable poly-L-lactic acid (PLLA) is world-famous filler used in lipoatrophy and facial rejuvenation because of its collagen neogenesis effect which leads to gradual volume restoration. Until recently, quite a number of unwanted adverse events of PLLA have been reported. However, to the best of our knowledge, paraffinoma as a complication of PLLA has never been reported. Read More

    Filler migration to the forehead due to multiple filler injections in a patient addicted to cosmetic fillers.
    J Cosmet Laser Ther 2017 Apr 25;19(2):124-126. Epub 2017 Jan 25.
    a Department of Dermatology , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.
    Filler migration is a potential complication following the injection of multiple fillers. With the increasing popularity of multiple filler injections, migrated granulomas should be an essential differential diagnosis for newly growing facial lumps. It is important for all physicians to be aware that complication induced by dermal fillers can occur in locations other than the planned injected sites. Read More

    Safety and performance of cohesive polydensified matrix hyaluronic acid fillers with lidocaine in the clinical setting - an open-label, multicenter study.
    Clin Cosmet Investig Dermatol 2016 20;9:373-381. Epub 2016 Oct 20.
    Rosenparkklinik GmbH, Darmstadt, Germany.
    Cohesive polydensified matrix (CPM(®)) hyaluronic acid fillers are now available with or without lidocaine. The aim of this study was to investigate the safety and performance of CPM(®) fillers with lidocaine in the clinical setting. In an open-label, prospective, postmarketing study, 108 patients from seven sites in Germany and Denmark were treated with one or more lidocaine-containing CPM(®) fillers. Read More

    Dermal fillers: pathophysiology, prevention and treatment of complications.
    J Eur Acad Dermatol Venereol 2017 Mar 28;31(3):405-413. Epub 2016 Oct 28.
    Department of Surgery and Laser Unit, St. John's Institute of Dermatology, Guy's and St. Thomas' Hospitals, London, UK.
    Dermal fillers are increasingly used for soft tissue augmentation of the face and hands. The widespread use of dermal fillers for rejuvenation has led to a rise in reports of associated complications. Although the majority of complications are mild and transient, serious and long-lasting complications have been observed. Read More

    Safety and Long-Term Efficacy of Forehead Contouring With a Polycaprolactone-Based Dermal Filler.
    Dermatol Surg 2016 Nov;42(11):1256-1260
    Hus-Hu Dermatology Clinic, Seoul, Korea.
    Background: Recently, a biostimulatory dermal filler based on polycaprolactone (PCL) microspheres was introduced. To our knowledge, no report has examined the safety and efficacy of PCL-based dermal fillers in forehead augmentation.

    Objective: To evaluate the safety and efficacy of forehead augmentation using a PCL-based dermal filler. Read More

    An Overview of Infections Associated With Soft Tissue Facial Fillers: Identification, Prevention, and Treatment.
    J Oral Maxillofac Surg 2017 Jan 14;75(1):160-166. Epub 2016 Sep 14.
    Chief, Section of Infectious Disease, Waterbury Hospital, Waterbury; Associate Clinical Professor of Medicine, Yale University School of Medicine, New Haven, CT.
    Purpose: The purpose of this study was to provide an overview of infections associated with facial soft tissue fillers.

    Materials And Methods: A literature review was performed which evaluated infections associated with facial soft tissue fillers.

    Results: Infection rates with soft tissue fillers are low and are estimated at 0. Read More

    Correction of Age-Related Midface Volume Loss With Low-Volume Hyaluronic Acid Filler.
    JAMA Facial Plast Surg 2017 Mar;19(2):88-93
    Greene.MD Plastic Surgery & Laser Center, Weston, Florida.
    Importance: The pivotal approval trial for a smooth, highly cohesive, viscous, 20-mg/mL hyaluronic acid filler demonstrated sustained aesthetic improvement, with a mean injection volume of 6.65 mL. In daily practice, however, it is not often practical or necessary to use large injection volumes to achieve the desired cosmetic outcome. Read More

    Rejuvenation of the perioral and lip regions with two new dermal fillers: The Italian experience with Vycross(™) Technology.
    J Cosmet Laser Ther 2017 Feb 23;19(1):54-58. Epub 2016 Nov 23.
    c Plastic Surgeon , Verona , Italy.
    Background: Hyaluronic acid fillers are frequently used for maintenance of youthful appearance of perioral and lip region. The introduction of Juvederm(®) Volbella(™) with lidocaine and Juvederm(®) Volift(™) with lidocaine to the European aesthetic market in 2012 increased the options of fillers to be used and it appears to be a new solution to improve this area.

    Objective: the aim of this study is to demonstrate how to correct this area using two new dermal fillers: Juvederm(®) Volift(™) with lidocaine, and Juvederm(®) Volbella(™) with lidocaine, based on the experience of two Italian phycians. Read More

    Labia Majora Augmentation with Hyaluronic Acid Filler: Technique and Results.
    Aesthet Surg J 2016 Nov 30;36(10):1155-1163. Epub 2016 May 30.
    Dr Fasola is a microsurgeon in private practice in Milan, Italy. Dr Gazzola is a Resident, Department of Plastic Surgery, Università degli Studi di Milano, Milan, Italy.
    Background: External female genitalia lose elasticity and volume with age. In the literature several techniques address the redundancy of the labia minora, but only few reports describe the augmentation of labia majora with fat grafting. At present, no studies describe the augmentation of the labia majora with hyaluronic acid. Read More

    Delayed Adverse Subcutaneous Reaction to a New Family of Hyaluronic Acid Dermal Fillers With Clinical, Ultrasound, and Histologic Correlation.
    Dermatol Surg 2017 Apr;43(4):605-608
    Pérez & Gavín dermatólogos Clinic, Vigo, Spain Department of Radiology Department of Dermatology, Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Clinica Servet, University of Santiago de Chile, Santiago de Chile, Chile Service of Dermatology, Department of Pathology, Hospital Universitario de Salamanca Salamanca, Spain.

    An 18-Month Follow-up, Randomized Comparison of Effectiveness and Safety of Two Hyaluronic Acid Fillers for Treatment of Moderate Nasolabial Folds.
    Dermatol Surg 2017 Jan;43(1):58-65
    *RZANY & HUND, Privatpraxis, Berlin, Germany; †Department of Dermatology and Allergology, HSK Wiesbaden, Lehrkrankenhaus der Universität Mainz, Wiesbaden, Germany; ‡Department of Dermatology, Cannes Hospital, Cannes, France; §Centre dermato-chirurgical et médecine de la nutrition, Bordeaux, France; ‖Dermatologische Praxis, Wuppertal, Germany; ¶CPCAD, Hôpital l'Archet 2, Nice, France; #Gemeinschaftspraxis für Dermatologie, Mahlow, Germany; **Praxis Dr. med. Boris Sommer, Frankfurt, Germany; ††Galderma, Uppsala, Sweden; ‡‡Department of Dermatology, Klinikum Darmstadt, Darmstadt, Germany.
    Background: Hyaluronic acid (HA) filler injection is a popular nonsurgical aesthetic procedure.

    Objective: To compare the effectiveness and safety of 2 hyaluronic acid fillers (HAEC and HARES) for treatment of moderate nasolabial folds (NLFs).

    Materials And Methods: This was an evaluator- and subject-blinded split-face study. Read More

    Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review.
    Clin Cosmet Investig Dermatol 2016 8;9:257-80. Epub 2016 Sep 8.
    Victoria Park Clinical Research Centre, Westmount, QC, Canada.
    Background: Cohesive monophasic polydensified fillers show unique viscoelastic properties and variable density of hyaluronic acid, allowing for a homogeneous tissue integration and distribution of the material.

    Objective: The aim of this paper was to review the clinical data regarding the performance, tolerability, and safety of the Belotero(®) fillers for soft-tissue augmentation and rejuvenation.

    Methods: A literature search was performed up until May 31, 2015 to identify all relevant articles on Belotero(®) fillers (Basic/Balance, Hydro, Soft, Intense, Volume) and equivalent products (Esthélis(®), Mesolis(®), Fortélis(®), Modélis(®)). Read More

    Volume correction in the aging hand: role of dermal fillers.
    Clin Cosmet Investig Dermatol 2016 30;9:225-32. Epub 2016 Aug 30.
    David Geffen/UCLA School of Medicine Los Angeles, CA, USA.
    The hands, just like the face, are highly visible parts of the body. They age at a similar rate and demonstrate comparable changes with time, sun damage, and smoking. Loss of volume in the hands exposes underlying tendons, veins, and bony prominences. Read More

    The Value of Full Correction: Achieving Excellent and Affordable Results.
    Plast Surg Nurs 2016 Jul-Sep;36(3):110-3
    Julie Bass Kaplan, MSN, RN, CPSN, CANS, PHN, HCMT, works for Allergan as a speaker/trainer, Scientiae Palette Resources as a speaker/trainer, and CosmoFrance as a regional trainer for DermaSculpt MicroCannulas.
    Patients often come to medical aesthetic offices with hopes to fully correct lost facial volume and achieve a natural appearance. Unfortunately, the cost per syringe of dermal filler can be a barrier to desired outcomes. Many aesthetic practitioners do the best they can with the amount of product the patient can afford, often falling short of the "wow" effect for the patient. Read More

    Understanding the Anatomy of the Upper Face When Providing Aesthetic Injection Treatments.
    Plast Surg Nurs 2016 Jul-Sep;36(3):104-9
    Tracey A. Hotta, BScN, RN, CPSN, is the owner of TH Medical Aesthetics and President of THMA Consult Inc.
    Advanced rejuvenation procedures for the upper face are becoming increasingly popular for aesthetic providers but are considered a high-risk treatment area for dermal filler/contouring products. Risks may range from bruising, which is manageable, to blindness, most often irreversible. Detailed comprehension of the facial anatomy is imperative when performing aesthetic injections including neuromodulators and dermal filler/contouring products. Read More

    Effect of molecular weight of hyaluronic acid (HA) on viscoelasticity and particle texturing feel of HA dermal biphasic fillers.
    Biomater Res 2016 7;20(1):24. Epub 2016 Sep 7.
    Beautiful Revolution Co., Ltd., Seoul, 135-513 Republic of Korea.
    Background: Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. The fillers consist of crosslinked HA microspheres suspended in a noncrosslinked HA. To extend the duration of HAs within the dermis and obtain the particle texturing feel, HAs are crosslinked to obtain the suitable mechanical properties. Read More

    Composite Volumization of the Aging Face: Supra-Periosteal Space as the Foundation for Optimal Facial Rejuvenation.
    J Drugs Dermatol 2016 Sep;15(9):1136-41
    Current concepts of facial aging propose that volume losses of bone and fat in specific compartmentalized areas are the primary and the most important causes of the characteristic changes seen in the aging face. The authors propose that the use of Radiesse in the supra-periosteal space of the temple, zygomatic arch, anterior cheek, pyriform aperture, and pre-jowl sulcus most effectively and most efficiently corrects these volume losses, and therefore best helps to restore a youthful appearance. Placement of filler directly on bone produces a lifting effect on all of the overlying tissues as a single unit which the authors term "composite volumization". Read More

    Rheological Properties of Calcium Hydroxylapatite With Integral Lidocaine.
    J Drugs Dermatol 2016 Sep;15(9):1107-10
    Background: Calcium hydroxylapatite with integral lidocaine, CaHA (+), received FDA approval in 2015 and CE mark approval in 2016. This formulation has been associated with significant pain reduction compared to CaHA. In a previous rheometry study, CaHA without lidocaine demonstrated higher viscosity and elasticity when compared with hyaluronic acid fillers. Read More

    Visual, Ultrasonographic, and Microscopic Study on Hyaluronic Acid-Based Gel.
    J Drugs Dermatol 2016 Sep;15(9):1092-8
    Background: Hyaluronic acid (HA) fillers are commonly used for enhancement of lips, and for softening fine lines and correcting skin depressions.

    Objective: This study sought to investigate whether the Vycross technology used for Volbella gel resulted in a cohesive gel, as documented in our previous studies with three other HA fillers (Restylane® NASHA [Q-MED, Uppsala, Sweden], Esthélis® Basic CPM™ [Anteis SA, Geneva, Switzerland], and Juvéderm® Ultra 3 using Hylacross technology [Allergan, Irvine, CA, USA]).

    Method: The "resistance traction test" and "cohesiveness test" were conducted according to standard methods. Read More

    Lip Injection Techniques Using Small-Particle Hyaluronic Acid Dermal Filler.
    J Drugs Dermatol 2016 Sep;15(9):1076-82
    The shape and fullness of the lips have a significant role in facial aesthetics and outward appearance. The corrective needs of a patient can range from a subtle enhancement to a complete recontouring including correction of perioral rhytides. A comprehensive understanding of the lower face anatomical features and injection site techniques are foundational information for injectors. Read More

    Patient Reported Outcomes from HIV Facial Lipoatrophy Treatment With a Volumizing Hyaluronic Acid Filler: A Prospective, Open-Label, Phase I and II Study.
    J Drugs Dermatol 2016 Sep;15(9):1064-9
    Background: Human immunodeficiency virus (HIV) facial lipoatrophy (FLA) is associated with the use of highly active antiretroviral therapy (HAART) and HIV disease. HIV FLA is primarily characterized by midface (cheeks and temples) volume loss, resulting in a "sunken" and aged appearance. Filler agents for treatment of HIV FLA can provide midface volumization and improve quality-of-life (QOL). Read More

    A Randomized Clinical Trial of Comparing Monophasic Monodensified and Biphasic Nonanimal Stabilized Hyaluronic Acid Dermal Fillers in Treatment of Asian Nasolabial Folds.
    Dermatol Surg 2016 Sep;42(9):1061-8
    *All the authors are affiliated with the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
    Background: Cross-linked hyaluronic acids (HAs) with varying characteristics and formulations are available. Despite the popularity of HA, limited studies compared the effectiveness of monophasic monodensified hyaluronic acid (MMHA) and biphasic nonanimal stabilized hyaluronic acid (BHA) products in correcting nasolabial folds (NLFs) in the Asian population.

    Objective: This double-blinded, randomized research aimed at evaluating the outcomes of MMHA and BHA products in treating Asian NLFs. Read More

    Streptococcus sanguinis isolated from filler granuloma: Successful treatment with incision and drainage.
    Dermatol Ther 2016 Nov 19;29(6):463-465. Epub 2016 Aug 19.
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    Filler granuloma is considered to be the result of delayed immune responses; growing evidence suggests that they may be secondary to biofilm formation. Dermal filler is technically a foreign body, and as the development of newer generations of dermal fillers lengthens their duration, it is possible that there is also an increased risk of biofilm formation. Here, we present a case report of a patient with Streptococcus sanguinis isolated from a filler granuloma, suggestive of biofilm formation. Read More

    Calcium Hydroxylapatite With Integral Lidocaine Provides Improved Pain Control for the Correction of Nasolabial Folds.
    J Drugs Dermatol 2016 Aug;15(8):1005-10
    Calcium hydroxylapatite microspheres in a carrier gel (CaHA; Radiesse®: Merz North America, Inc., Raleigh, NC) is approved by the United States Food and Drug Administration for subdermal implantation for the correction of moderate-to-severe facial wrinkles and folds, such as nasolabial folds (NLFs). Lidocaine is often mixed with injectable dermal fillers to reduce injection pain. Read More

    The Aging Face: Global Approach With Fillers and Neuromodulators.
    Semin Cutan Med Surg 2016 Jun;35(6 Suppl):S120-1
    Assistant Professor University of Toronto Toronto, Ontario, Canada.
    The goal of treating the aging face is to restore facial balance and modify shadows. A facial evaluation should focus on areas of volume loss and opportunities to use neuromodulators (eg, botulinum toxin A) and the use of fillers. A thorough understanding of facial anatomy, including muscles, nerves, bone, and fat pads, is essential for effective and safe treatment. Read More

    Fillers: What's Here and What's Ahead.
    Semin Cutan Med Surg 2016 Jun;35(6 Suppl):S117-9
    Assistant Professor University of Toronto Toronto, Ontario, Canada.
    Soft tissue augmentation products (or fillers) are used for the correction of age-related changes in areas of the face. The most common filler material is hyaluronic acid, which is synthetically cross-linked. These materials are generally safe, but some side effects do occur. Read More

    An Anatomical Analysis of the Supratrochlear Artery: Considerations in Facial Filler Injections and Preventing Vision Loss.
    Aesthet Surg J 2017 Feb 16;37(2):203-208. Epub 2016 Aug 16.
    Drs Khan and Colon-Acevedo are Fellows in Oculoplastic and Reconstructive Surgery, Dr Mettu is a Fellow in Neuro-ophthalmology, and Dr Woodward is Chief of Oculoplastic and Reconstructive Surgery, Duke University Eye Center, Durham, NC. Dr DeLorenzi is a plastic surgeon in private practice in Kitchener, Ontario, Canada.
    Background: Embolia cutis medicamentosa (ECM) is a rare phenomenon attributed to intra-arterial drug injection. Glabellar filler injections can result in potentially devastating visual loss from inadvertent retrograde arteriolar embolization due to the extensive vasculature within the upper face. The minimum amount of filler necessary to potentiate this complication has not yet been reported. Read More

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