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Aesthet Surg J 2019 Feb 19. Epub 2019 Feb 19.

Private practice in Seoul, Korea.

Background: During aging, facial skin thins, atrophies, and loses elasticity. Subdermal filler injections can volumize and treat wrinkles but cannot directly change dermal thickness. Polycaprolactone (PCL)-fillers can improve skin texture and quality through dermal thickening and inducing neocollagenesis. Read More

Toxicol Ind Health 2019 Feb 13:748233719825531. Epub 2019 Feb 13.

1,1,1,3,3,3-Hexamethyldisilazane (HMDZ) is used industrially to treat the surface of silica, as an intermediate adhesion promoter or silylating agent in the semiconductor industry, as a chemical modifier of inorganic fillers, and as a water scavenger silicone sealant. In animal studies, HMDZ is considered to be slightly to at most moderately toxic following acute administration via oral, dermal, and inhalation routes of exposure. HMDZ is neither an eye irritant nor was it dermally irritating under semiocclusive conditions; however, it caused dermal necrosis in two studies under occlusive conditions. Read More

J Am Acad Dermatol 2019 Mar;80(3):591-602

Department of Dermatology, Kaiser Permanente, San Francisco, California.

Lesbian, gay, bisexual, and transgender (LGBT) persons face important health issues relevant to dermatologists. Men who have sex with men (MSM) are at higher risk of certain infectious diseases, including HIV, syphilis and other sexually transmitted diseases (STDs), methicillin-resistant Staphylococcus aureus infections, and invasive meningococcal disease, and might be at higher risk of non-infectious conditions, including skin cancer. Recommendations for preventive health care, including screening for HIV and other STDs, sexual health-related vaccinations, and HIV pre-exposure prophylaxis, differ for MSM compared with non-MSM. Read More

J Cosmet Dermatol 2019 Jan 31. Epub 2019 Jan 31.

TLC Lifestyle Practice, Scotts Medical Center at Pacific Plaza, Singapore City, Singapore.

A handheld 2 MHz ultrasound Doppler device determines the presence or absence of pulsatile arterial flow immediately beneath the selected site of entry for dermal filler injection. In combination with near infrared technology to map out superficial veins, mishaps from intravascular injections may be reduced. A total of 448 patients aged range between 21 and 74 years, with 168 out of total of 1019 treatment sites having both infrared and ultrasound Doppler assisted preinjection mapping were reviewed. Read More

J Drugs Dermatol 2019 Jan;18(1):86-91

Background: Calcium hydroxylapatite (CaHA, Radiesse®) with integral 0.3% lidocaine (CaHA(+)) has recently been approved for use in aesthetic medicine. This study assessed the performance of CaHA(+) in subjects undergoing treatment for facial volume loss and evaluated subject and physician satisfaction. Read More

J Drugs Dermatol 2019 Jan;18(1):67-74

Objective: To study the safety, efficacy, optimal volume, and longevity of an injectable hyaluronic acid (HA) gel dermal filler to treat facial temporal fossa fat loss. Methods and materials: This open-label, single-site, 12-month study used 20 mg/mL HA gel to correct volume loss in both temples in 30 subjects. Touch-ups were allowed at week 2. Read More

Dermatology 2019 Jan 16:1-8. Epub 2019 Jan 16.

Objective: Dermal fillers are an important tool in the field of aesthetic dermatology. Fillers are relatively noninvasive and easy to use but are not free of secondary complications. The main complications are vascular and are due to either the compression of an artery or the direct introduction of the product into the arterial lumen. Read More

Aesthet Surg J 2019 Jan 14. Epub 2019 Jan 14.

Department of Maxillofacial Plastic Surgery, Division of Dental and Maxillofacial Surgery and the Department of Public Health and Community Medicine, Unit of Epidemiology and Medical Statistics, G.B. Rossi Hospital and Medical University of Verona, Verona, Italy.

Background: The bad outcomes of a facial trauma could have a strongly negative psychological impact and compromise patient's quality of life. Unfortunately, surgery cannot always solve this problem or give an acceptable result.

Objectives: Aesthetic medicine treatments with injectables may provide a solution that is minimally invasive and more accepted by the patients in improving bad outcomes after facial trauma. Read More

Br Dent J 2018 Dec;225(12):1049

Dermatol Surg 2018 Dec 18. Epub 2018 Dec 18.

Maryland Dermatology, Laser, Skin and Vein Institute, Hunt Valley, Maryland.

Background: Hyaluronic acid fillers (HAFs) and energy-based devices are frequently used sequentially. However, the effect of using fractional devices directly over HAF is unclear.

Objective: To evaluate histologic changes after fractional laser and radiofrequency (RF) therapies applied over preinjected HAF. Read More

J Am Acad Dermatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pharmaceutical Science, State University of Ponta Grossa, Brazil.

Clin Cosmet Investig Dermatol 2018 23;11:603-611. Epub 2018 Nov 23.

Institute of Medical and Biomedical Education, St George's University of London, London, UK.

The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures. Read More

Plast Reconstr Surg Glob Open 2018 Oct 2;6(10):e1909. Epub 2018 Oct 2.

CHAO Institute of Aesthetic Medicine, Taipei, Taiwan.

A 3-dimensional, multi-layered approach combining modalities targeting different manifestations is recommended for achieving optimal esthetic outcomes. To date, studies reporting same-day treatment with dermal fillers and botulinum toxin have not been published. This article documents the practical use of a single-visit, pan-facial multimodal approach in addressing the varying esthetic needs of 8 Asian adults. Read More

J Drugs Dermatol 2018 Nov;17(11):1245-1246

Introduction: Google Search is an important tool for patients researching skin care treatments and finding dermatologists. Data from individual patient’s searches are aggregated by Google and yield powerful data sets that can be used to trend population behaviors. This study investigates the correlations between the volume of Google searches and the number of procedures performed annually for both botulinum toxin type A and hyaluronic acid tissue fillers. Read More

J Drugs Dermatol 2018 Nov;17(11):1184 -1185

Bruising after dermal filler and neuromodulator injections is a common side effect and can have durations of 1 to 2 weeks. While it ultimately resolves, faster resolution can produce better outcomes for patients and also make patients more likely to return for future treatments. We report the successful reduction in bruising following injections of fillers with an intense pulsed light source. Read More

Med Devices (Auckl) 2018 15;11:367-376. Epub 2018 Oct 15.

Scientific Department, Skin Tech Pharma Group, Castello D'Empúries, Cataluña, Spain,

Background: Hyaluronic acid (HA), a naturally occurring polysaccharide, is used in the production of dermal fillers for esthetic purposes. As it has a few days of half-life in human tissues, HA-based dermal filler is chemically modified to increase its lifetime in the body. The most common modification used in commercial HA-based filler is the cross-linking of HA chains using 1,4-butanediol diglycidyl ether (BDDE) as cross-linking agent. Read More

Prim Care 2018 Dec;45(4):705-717

Department of Family Medicine, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. Electronic address:

Plastic surgery is a broad field, including maxillofacial surgery, reconstruction after injuries, hand surgery, and skin flaps and grafts, but the most common procedures for women are liposuction and body contouring, breast surgery, and facial cosmetic procedures. Techniques of face and brow lifts, blepharoplasty, and rhinoplasty are discussed as well as botulinum toxin and filler injections, and laser and pulsed light techniques that may delay or eliminate the need for surgery. Comparison of the surgeries for breast reconstruction, reduction, augmentation, and mastopexy is discussed. Read More

J Cosmet Laser Ther 2018 Nov - Dec;20(7-8):424-435. Epub 2018 Nov 5.

b Residente de tercer año , Universidad del Rosario , Bogota , Columbia.

Background And Objectives: Acne scarring is a widely prevalent condition that can have a negative impact on a patient's quality of life and is often worsened by aging. A number of options are available for the treatment of acne scarring, including retinoids, microdermabrasion, dermal fillers, and surgical techniques such as subcision. The aim of this review is to evaluate the different laser modalities that have been used in peer-reviewed clinical studies for treatment of atrophic acne scars, and summarize current clinical approaches. Read More

Dermatol Surg 2018 11;44 Suppl 1:S60-S62

Directory of Dermatology, Aesthetx, Campbell, California Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Department of Dermatology, University of California, Los Angeles, California.

Dermatol Surg 2018 11;44 Suppl 1:S56-S60

Dermatology Division, Policlinica Geral do Rio de Janeiro (PGRJ), Rio de Janiero, Brazil Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California Dermatology Department, Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericordia do Rio de Janeiro, Rio de Janeiro, Brazil Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.

Dermatol Surg 2018 11;44 Suppl 1:S53-S56

Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.

Dermatol Surg 2018 11;44 Suppl 1:S32-S41

Department of Plastic Surgery, Lenox Hill Hospital, New York, New York.

Background: Calcium hydroxylapatite (CaHA) is approved to correct moderate-to-severe wrinkles and folds and soft-tissue volume loss in the face and hands. More recently, subdermal injection using diluted CaHA has been used to improve skin laxity.

Objective: To review evidence for the safe and effective use of diluted CaHA in the face and body and provide best practice recommendations. Read More

Dermatol Surg 2018 11;44 Suppl 1:S10-S18

Galderma Aesthetics, Uppsala, Sweden.

Background: Acne scarring affects most patients with acne and have a negative impact on quality of life. New effective treatment options offering minimal downtime are therefore needed.

Objective: To evaluate improvement in overall facial appearance after hyaluronic acid (HA) treatment of atrophic acne scars. Read More

Dermatol Surg 2018 11;44 Suppl 1:S5-S9

Modern Dermatology, Westport, Connecticut.

Background: A dissolving agent for calcium hydroxylapatite (CaHA, Radiesse) soft-tissue filler would be of value should inadvertent intravascular injection, vascular compromise, nodule formation, or overcorrection occur.

Methods: In a prospective, single-center, proof-of-concept study, 12 cadaveric porcine skin samples were injected with CaHA (0.4-0. Read More

Dermatol Surg 2018 11;44 Suppl 1:S2-S4

Department of Dermatology, Carruthers Dermatology Centre, Vancouver, British Columbia, Canada.

Background: Worldwide, the brow is the most common facial site to receive aesthetic treatment. However, the forehead above the brows has been comparatively less well studied with respect to both neuromodulators and fillers. Age-related remodeling of the forehead with loss of facial bone has been demonstrated on detailed radiographic studies. Read More

Dermatol Surg 2018 11;44 Suppl 1:S1

Carruthers & Humphrey Cosmetic Dermatology and.

Open Access Maced J Med Sci 2018 Sep 23;6(9):1636-1641. Epub 2018 Sep 23.

Städtisches Klinikum Dresden, Academic Teaching Hospital Dresden, Department of Dermatology and Allergology, Dresden, Germany.

Background: Dermal fillers are widely used for facial and body contouring. Polymethylmethacrylate (PMMA) is a permanent biphasic filler for soft tissue augmentation. In case of unwanted side effects, drug therapy and surgical excision have been commonly used with mixed results. Read More

J Plast Reconstr Aesthet Surg 2019 Jan 27;72(1):131-136. Epub 2018 Sep 27.

Department of Plastic and Reconstructive Surgery, University Hospital Nice, Pasteur 2, 30, avenue de la Voie Romaine, 06000 Nice, France.

Background: Over the past decade, cosmetic injections of dermal fillers or fat have become a popular procedure in facial rejuvenation in an overconsuming society. However, complications such as arterial embolism and occlusion can occur even with experienced injectors, especially in high-risks zones namely the glabella, the nasal dorsum or the nasolabial fold. The aim of this study was to define the vascular danger zones of the infraorbital area in order to provide guidelines helping avoid them. Read More

J Cosmet Dermatol 2018 Oct;17(5):736-743

Private practice, Mulhouse, France.

Sound knowledge of the rheology of hyaluronic acids is fundamental for facial rejuvenation procedures. Hyaluronic acid implants are subjected to complex mechanical forces within the facial tissues that vary depending on the anatomical region. Analysis of these forces is important to establish the rheological specifications of hyaluronic acid implants in each specific zone. Read More

Facial Plast Surg 2018 Oct 8;34(5):497-504. Epub 2018 Oct 8.

Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas.

The periorbital region is a focal point on the face. Dermatochalasis, fat herniation, blepharoptosis, brow ptosis, deep tear troughs, and malar fat pad descent are all age-related changes that occur around the eyes, and successful rejuvenation involves addressing all of these changes. Restoring a youthful, vibrant appearance to the eyes and periorbital areas can often only be accomplished with a combination of surgical and nonsurgical interventions. Read More

Facial Plast Surg 2018 Oct 8;34(5):466-473. Epub 2018 Oct 8.

Division of Facial Plastic Surgery, Advanced Facial Plastic Surgery Center, Dallas, Texas.

The periorbital and forehead regions are among the most expressive parts of the face. A thorough understanding of the complex facial anatomy and aesthetic norms are essential when evaluating and treating a patient for facial brow rejuvenation. Not only will knowledge of the anatomy enhance facial injection and surgical outcomes, but will also diminish potential complications. Read More

Int J Biol Macromol 2018 Dec 1;120(Pt B):1682-1695. Epub 2018 Oct 1.

Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia. Electronic address:

Hyaluronic acid (HA) plays multifaceted role in regulating the various biological processes such as skin repairmen, diagnosis of cancer, wound healing, tissue regeneration, anti-inflammatory, and immunomodulation. Owing to its remarkable biomedical and tissue regeneration potential, HA has been numerously employed as one of the imperative components of the cosmetic and nutricosmetic products. The present review aims to summarize and critically appraise recent developments and clinical investigations on cosmetic and nutricosmetic efficacy of HA for skin rejuvenation. Read More

J Cosmet Laser Ther 2018 Oct 4:1-2. Epub 2018 Oct 4.

c Department of Dermatology , KAIST , Daejeon , Republic of Korea.

Dermal fillers are highly favored around the globe as minimally invasive or nonsurgical procedures. Imatinib mesylate is the first-line treatment for patients diagnosed with chronic myeloid leukemia. However, some studies describe that imatinib mesylate may increase the tendency of skin fragility which can lead to easy bruising and hyperpigmentation after invasive skin procedures. Read More

Imaging Sci Dent 2018 Sep 18;48(3):227-231. Epub 2018 Sep 18.

Department of Oral and Maxillofacial Radiology, School of Dentistry, Kyungpook National University, Daegu, Korea.

In recent years, as interest in maintaining beauty and a youthful appearance has grown, filler procedures such as soft tissue augmentation have become more popular. These fillers are sometimes seen as radiopaque shadows on radiographic images, either due to the fillers themselves or because of secondary reactions; such findings may present a diagnostic challenge to dentists. The present report describes 3 cases of dermal fillers observed in panoramic and cone-beam computed tomographic (CBCT) images. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2018 Sep;27(3):165-167

Department of Dermatology and Venereology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Among several skin fillers developed in recent decades, hyaluronic acid (HA) fillers have become the material of choice. They are safe, long-lasting, not immunogenic, and cost effective, and they can be removed with hyaluronidase. Unfortunately, early and delayed complications can also occur following HA filler injection. Read More

J Drugs Dermatol 2018 Sep;17(9):999-1004

Introduction: Lip plumpers are topical agents that offer immediate, but temporary, volumization of the lips. While these products are becoming increasingly popular and are available at multiple retailers, there is a lack of clinical studies to evaluate the efficacy, longevity, and safety of the lip plumping products.

Methods: This is a prospective, single center, clinical trial to evaluate the duration, efficacy, and safety of a lip plumping agent in two clinical visits. Read More

J Drugs Dermatol 2018 Sep;17(9):941-946

Men's interest and participation in cosmetic procedures has increased in recent years; however, the factors that motivate or discourage men from undergoing these procedures is not well understood. To evaluate which factors impact men's decisions towards cosmetic procedures, an observational, single-site, cross-sectional study utilizing a voluntary questionnaire was executed in a target population size of 209 men ≥21 years old who visited the study site from 2015 to 2017. A majority of the male respondents incorporate a basic skincare regimen into their daily routine (90%), have had experience with neurotoxin treatments (54%), and expressed interest in either neurotoxin or dermal filler treatments (77% and 83%, respectively). Read More

Cutis 2018 Aug;102(2):E20-E23

Department of Dermatology, George Washington University School of Medicine & Health Sciences, Washington, USA.

Dermal fillers are medical devices regulated by the US Food and Drug Administration (FDA); therefore, reported adverse events (AEs) are publicly available via OpenFDA. Evaluation of historical AE data trends may help distinguish between AEs related to expected learning curves associated with a new type of filler from AEs related to inherent characteristics of a product. In this study, the full history of AE data was evaluated to establish reproducible learning curves for FDA-approved dermal fillers. Read More

J Craniofac Surg 2018 Oct;29(7):e726-e727

Department of Auricular Reconstruction, Plastic Surgery Hospital, Peking Union Medical College, Beijing, China.

Skin necrosis is a rare but severe potential complication after injection of hyaluronic acid (HA). Based on the understanding of the causes and mechanisms of this complication, many precautions have been proposed. Still, this adverse reaction happened from time to time. Read More

Facial Plast Surg Clin North Am 2018 Nov 16;26(4):439-446. Epub 2018 Aug 16.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine, 1305 York Avenue, Fifth Floor, New York, NY 10021, USA. Electronic address:

Platelet preparations, including platelet-rich plasma and platelet-rich fibrin matrix, have been used to improve wound healing, recovery time, and cosmetic outcomes for facial rejuvenation. Bioactive growth factors released from platelets are the putative agents in producing a reparative tissue reaction in the treated area. Different methods of processing the patients' blood will yield different types of platelet preparations with different components and properties, and it is important to understand these differences and their potential implications. Read More

J Cutan Aesthet Surg 2018 Apr-Jun;11(2):60-66

Medical Director and Consultant Dermatologist, RSV Skin and Research Centre, Senior Consultant Dermatologist Apollo Hosptials, Chennai.

Cosmetic filler injections are most popular among the antiaging procedures. As in any other cosmetic injectable procedures, complications are likely to occur even under experienced hands. However, it is the duty of the aesthetic physician to identify and manage these potential complications. Read More

Aesthet Surg J 2018 Sep 11. Epub 2018 Sep 11.

University of Verona, Verona, Italy.

Background: Nonsurgical lip enhancement using dermal fillers is a very popular procedure. The trend of enlarged lips has been popularised by media and social media. The lips have considerable aesthetic and functional importance, in addition to having a complex anatomy. Read More

Dermatol Ther 2018 Sep 4:e12623. Epub 2018 Sep 4.

Faculty of Mathematics and Natural Sciences, Institute of Biology and Environmental Protection, Pomeranian Academy, Slupsk, Poland.

Aesthetic dermatology (AD) is a rapidly growing subspecialty of dermatology. The acceptance of AD in scientific community and the society is associated with its competence, efficiency, and seriousness. This review highlights some recent developments toward new tools, techniques, and understanding in the field of AD. Read More

Plast Surg (Oakv) 2018 Aug 19;26(3):154-159. Epub 2018 Apr 19.

Liverpool John Moores University, Merseyside, Liverpool, United Kingdom.

This study reports on an empirically underdocumented practice in contemporary aesthetic enhancement culture, the self-injection of unregulated DIY Botox and dermal filler kits purchased online. Data were collected from 4 online discussion forums containing disclosures in relation to use of DIY kits and analyzed using ethnographic content analysis. Motivation to source DIY Botox and dermal fillers online was grounded in desire to avoid financial cost of professional services and a lack of confidence in practitioners. Read More

Cutis 2018 Jul;102(1):21;25;47;48

Goldenberg Dermatology, PC, New York, USA.

Acne vulgaris and postacne scarring are common in the general population. Even after lesions have resolved, scarring can lead to detrimental psychologic effects and can negatively impact patients' quality of life. Fortunately, there have been several recent advances in therapeutic options to treat acne scarring. Read More

Eur J Med Res 2018 Aug 20;23(1):37. Epub 2018 Aug 20.

Departments of Dermatology, Medical Faculty, Research Laboratory for Dermatology and Immunology, Heinrich-Heine-University Duesseldorf, University Hospital Duesseldorf, Duesseldorf, Germany.

Background: Hyaluronidase is a hyaluronic acid (HA) metabolizing enzyme, which is approved as an adjuvant for infiltration anesthesia. The "off-label" use of hyaluronidase is regarded as gold standard for the management of HA-filler-associated complications. Yet, up to date there are only few studies that have systematically assessed the degradability of different HA-fillers by hyaluronidase. Read More

J Am Acad Dermatol 2018 09;79(3):423-435

Division of Dermatology, Loyola University Medical Center, Maywood, Illinois.

Injectable fillers and neuromodulators are used for a range of indications pertaining to the correction of facial aging and disfigurement. Fillers can correct soft tissue loss, depressed scars, and atrophy or asymmetry induced by systemic or local disease. Neuromodulators correct muscle-mediated skin creases, reshape the face, and address right-left functional asymmetry. Read More

J Am Acad Dermatol 2018 09;79(3):407-419

Division of Dermatology, Loyola University Medical Center, Maywood, Illinois.

Cosmetic dermatologic surgery has evolved to be a minimally invasive field that addresses patient concerns with a multimodal approach while minimizing adverse events and downtime. Within the armamentarium of dermatologic surgery, injections of soft tissue augmentation materials and neuromodulators are key tools for recontouring the aging face. Treatment of the individual patient is preceded by a comprehensive consultation that elicits patient concerns and preferences. Read More

Biomater Sci 2018 Sep;6(10):2627-2638

Center for Convergence Bioceramic Materials, Convergence R&D Division, Korea Institute of Ceramic Engineering and Technology, 202, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, Republic of Korea.

The use of injectable materials as a biofiller for soft tissue augmentation has been increasing worldwide. Levan is a biocompatible and inexpensive polysaccharide with great potential in biomaterial applications, but it has not been extensively studied. In this study, we evaluated the potential of levan as a new material for dermal fillers and prepared an injectable and physical levan-based hydrogel by combining levan with Pluronic and carboxymethyl cellulose (CMC). Read More

Dermatol Surg 2018 11;44 Suppl 1:S51-S53

Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada Pacific Derm, Vancouver, British Columbia, Canada Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.