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    CALCIUM HYDROXYLAPATITE MICROSPHERES - BIOCOMPATIBILITY AND CLINICAL EFFECTS.
    Georgian Med News 2018 May(278):62-68
    1Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden; 2Department of Dermatology, Jena University Hospital, Germany.
    Soft tissue fillers are used in aesthetic medicine for volumizing and for contouring. Calcium hydroxylapatite (CaHA) is a fully biodegradable biostimulatory filler. The study presents results of in vitro biocompatibility and cytotoxicity investigations performed on CaHA and illustrates its clinical effects. Read More

    Durability, Behavior, and Tolerability of 5 Hyaluronidase Products.
    Dermatol Surg 2018 Jun 8. Epub 2018 Jun 8.
    Apothekon, Inc., St. Paul, Minnesota.
    Background: Hyaluronic acid (HA) dermal fillers are commonly used in cosmetic dermatology. Due to differences in their physical characteristics, HA fillers demonstrate different sensitivity to degradation by hyaluronidase (Hase) because of HA concentration and differences in cross-linking. Similarly, there are differences in the activity of Hase products depending on source and concentration. Read More

    Brazilian Consensus Recommendation on the Use of Polymethylmethacrylate Filler in Facial and Corporal Aesthetics.
    Aesthetic Plast Surg 2018 Jun 5. Epub 2018 Jun 5.
    Division of Plastic Surgery, University of California, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
    Background: Considering that aesthetic benefits can be obtained with the use of permanent filling materials, this work focuses on the development of a consensus regarding the facial and corporal use of polymethylmethacrylate (PMMA) filler in Brazil.

    Methods: A questionnaire regarding PMMA treatment, which included items on the main indication, application site, volume of product applied, criteria for selection of the material, complications, contraindications, and individual professional experience, was distributed to the Expert Group members. In addition, the responses were summarized, constituting the starting point for the debate regarding the use of PMMA-based fillers on The First Brazilian PMMA Symposium to create a guideline to be followed in PMMA facial and corporal treatments. Read More

    Definitions of groove and hollowness of the infraorbital region and clinical treatment using soft-tissue filler.
    Arch Plast Surg 2018 May 15;45(3):214-221. Epub 2018 May 15.
    Samskin Plastic Surgery Clinic, Seoul, Korea.
    Clarification is needed regarding the definitions and classification of groove and hollowness of the infraorbital region depending on the cause, anatomical characteristics, and appearance. Grooves in the infraorbital region can be classified as nasojugal grooves (or folds), tear trough deformities, and palpebromalar grooves; these can be differentiated based on anatomical characteristics. They are caused by the herniation of intraorbital fat, atrophy of the skin and subcutaneous fat, contraction of the orbital part of the orbicularis oculi muscle or squinting, and malar bone resorption. Read More

    Comparative Study of UMA Jeunesse Classic and UMA Jeunesse Ultra.
    Aesthetic Plast Surg 2018 May 14. Epub 2018 May 14.
    AC Aesthetic Clinic, London, England, UK.
    Introduction: The emergence of hyaluronic acid dermal fillers with lidocaine has transformed the minimally invasive treatment of wrinkles, lines and folds of the face. Patients can be treated quickly, painlessly and without the need for large doses of lidocaine. Therefore, it is important to scientifically evaluate the merits of lidocaine-containing products over those without. Read More

    Granuloma as a complication of polycaprolactone-based dermal filler injection: ultrasound and histopathology studies.
    J Cosmet Laser Ther 2018 May 14:1-4. Epub 2018 May 14.
    d Department of Diagnostic Imaging of the II Medical Faculty of the Medical University of Warsaw , Warsaw , Poland.
    In aesthetic medicine, there has been an ongoing search for an ideal dermal filler to offer zero complication rate. Polycaprolactone-based dermal filler (PCL) has been available since 2009. The purpose of the paper was to present a case of granuloma as a complication of PCL injection, which has not been reported so far by other researchers. Read More

    Intralesional Laser Treatment for Dermal Filler Complications.
    Plast Reconstr Surg 2018 Jun;141(6):1361-1369
    Rotterdam, Meijel, and 's-Hertogenbosch, The Netherlands From the Dermatology Department, Erasmus Medisch Centrum; Alizonne Kliniek Molenbaan; and Lareb.
    Background: For complications caused by filler treatments, in general, two treatment regimens are advised: systemic drugs and surgical removal of the material. Another possible treatment option would be removal of the material by intralesional laser treatment.

    Methods: Two hundred forty-two patients with complications caused by fillers were treated with intralesional laser treatment. Read More

    Hyaluronic acid dermal fillers in the management of recurrent angular cheilitis: A case report.
    Gerodontology 2018 Jun;35(2):151-154
    Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Santiago de Compostela, Spain.
    Objective: To report conservative treatment based on the use of dermal fillers for a case of recurrent angular cheilitis.

    Case Report: An 80-year-old patient with a history of recurrent angular cheilitis that was not resolved with a conventional approach sought treatment. Complete remission of the pathology was achieved with the injection of hyaluronic acid fillers. Read More

    Safety and Effectiveness of the Hyaluronic Acid Dermal Filler VYC-17.5L for Nasolabial Folds: Results of a Randomized, Controlled Study.
    Dermatol Surg 2018 May;44(5):670-678
    Allergan plc, Irvine, California.
    Background: Juvéderm Vollure XC (VYC-17.5L) belongs to a family of nonanimal hyaluronic acid (HA) gels based on the Vycross technology platform.

    Objective: To evaluate the safety and effectiveness of VYC-17. Read More

    Physical properties of a novel small-particle hyaluronic acid filler: In vitro, in vivo, and clinical studies.
    J Cosmet Dermatol 2018 Jun 23;17(3):347-354. Epub 2018 Apr 23.
    Department of Dermatology, Chung-Ang Hospital, Chung-Ang University, Seoul, Korea.
    Background: Infraorbital region is one of the most important regions that show the signs of aging. In recent years, hyaluronic acid (HA) fillers have been used to correct this region for esthetic treatments. Although HA fillers with various physical properties are used, limited research has been performed to compare their efficacy. Read More

    Autologous Fat Transfer for Facial Rejuvenation: A Systematic Review on Technique, Efficacy, and Satisfaction.
    Plast Reconstr Surg Glob Open 2017 Dec 22;5(12):e1606. Epub 2017 Dec 22.
    Department of Plastic, Reconstructive and Hand Surgery, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Plastic, Reconstructive and Hand Surgery, VU Medical Center, Amsterdam, The Netherlands; and Department of Epidemiology & Biostatistics, VU Medical Center, Amsterdam, The Netherlands.
    Background: Parallel to the steady decline in surgical aesthetic procedures to the face, dermal fillers seem to have gained a more prominent place in facial rejuvenation over the last couple of years. As a dermal, facial filler, autologous fat transfer (AFT) seems to have real potential because of the biocompatibility of adipose tissue besides being a procedure with few and primarily minor complications. This systematic review aims to evaluate the available evidence regarding the safety and effectiveness of AFT for facial rejuvenation. Read More

    Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers.
    Plast Reconstr Surg Glob Open 2017 Dec 22;5(12):e1532. Epub 2017 Dec 22.
    Laser and Light Cosmetic Medical Skin Clinic, Loughborough, United Kingdom.
    Objective: Even though injectable hyaluronic acid (HA)-based fillers are considered safe, rare complications, such as late-onset inflammatory reactions have been reported. Possible causes and effective treatments have not been formally described, so this work aims to discuss these and offer a formal protocol for treatment.

    Methods: This article presents 5 clinical cases of late-onset inflammatory response occurring at least 3 months after uneventful injection of HA dermal filler. Read More

    Optimizing outcomes with polymethylmethacrylate fillers.
    J Cosmet Dermatol 2018 Jun 30;17(3):298-304. Epub 2018 Mar 30.
    Sadick Dermatology, New York, NY, USA.
    Introduction: The ideal filler should be long-lasting, biocompatible, chemically inert, soft and easy to use, and have a long history of safety. This review focuses on the evolution and development of the PMMA-collagen gel, Bellafill, and the 10 years of postmarketing experience of Bellafill since it received premarket approval (PMA) from the FDA as Artefill in 2006. Artefill was rebranded to Bellafill in 2015. Read More

    Randomized, Patient/Evaluator-Blinded, Intraindividual Comparison Study to Evaluate the Efficacy and Safety of a Novel Hyaluronic Acid Dermal Filler in the Treatment of Nasolabial Folds.
    Dermatol Surg 2018 Apr;44(4):542-548
    Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
    Background: Comparative research on the characteristics of filler products is limited, especially in the preclinical analysis of hyaluronic acid (HA) fillers.

    Objective: This study was performed to compare the preclinical characteristics, clinical efficacy, and safety of a new HA filler, IDHF-001, with Restylane SubQ in the treatment of nasolabial folds (NLFs).

    Methods: Viscoelasticity and injection force were evaluated. Read More

    Late Presentation of Infected Silicone Granulomas in the Lower Limb.
    Clin Med Insights Arthritis Musculoskelet Disord 2018 22;11:1179544118759020. Epub 2018 Feb 22.
    Department of Pathology, Royal Free Hospital, London, UK.
    Introduction: Dermal fillers are used for multiple cosmetic indications including gluteal and thigh augmentation. Complications, although infrequent, are increasing due to the dramatic growth of dermal filler use. Our aim was to describe how the complication of infected silicone granulomas can present following lower limb augmentation. Read More

    Attention to Infection Prevention in Medical Aesthetic Clinics.
    Plast Surg Nurs 2018 Jan/Mar;38(1):17-24
    Tracey A. Hotta, BScN, RN, CPSN, CANS, LNC, Owner of TH Medical Aesthetics and Director of THMA Consulting Inc, Thornhill, Ontario, Canada.
    The risk of infection is a concern for all medical aesthetic industry and all providers. Steps to reduce the risk and improve patient outcomes begin with vigilance to proper aseptic technique and being less concerned about the "beauty image" to attract new patients. This article is based on the guidelines outlined in Infection Prevention and Control for Clinical Office Practice by Public Health Ontario. Read More

    Hyperbaric Oxygen for Ischemia due to Injection of Cosmetic Fillers: Case Report and Issues.
    Plast Reconstr Surg Glob Open 2018 Jan 11;6(1):e1618. Epub 2018 Jan 11.
    Division of Plastic & Reconstructive Surgery, University of Nebraska Medical Center, Omaha, Neb.; and Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Neb.
    Natural and synthetic fillers have revolutionized aesthetic facial rejuvenation and soft-tissue augmentation. We present a case highlighting the dangers of filler self-injection. A 37-year-old woman self-injected a dermal filler around both temples. Read More

    [Facial injections of hyaluronic acid-based fillers for malformations. Preliminary study regarding scar tissue improvement and cosmetic betterment].
    Ann Chir Plast Esthet 2018 Jun 3;63(3):197-204. Epub 2018 Feb 3.
    Service de chirurgie maxillo-faciale et chirurgie plastique, hôpital universitaire Necker-enfants-malades, centre de référence fentes et malformations faciales, 149, rue de Sèvres, 75015 Paris, France; Faculté de médecine Paris-Descartes, université Paris 5, 75006 Paris, France.
    Background: Cross-linked hyaluronic acid-based fillers have gained rapid acceptance for treating facial wrinkles, deep tissue folds and sunken areas due to aging. This study evaluates, in addition to space-filling properties, their effects on softness and elasticity as a secondary effect, following injection of 3 commercially available cross-linked hyaluronic acid-based fillers (15mg/mL, 17,5mg/mL and 20mg/mL) in patients presenting with congenital or acquired facial malformations.

    Patients Et Methods: We started injecting gels of cross-linked hyaluronic acid-based fillers in those cases in 2013; we performed 46 sessions of injections in 32 patients, aged from 13-32. Read More

    An innovative method to quantitate tissue integration of hyaluronic acid-based dermal fillers.
    Skin Res Technol 2018 Feb 2. Epub 2018 Feb 2.
    Galderma R&D, Sophia Antipolis, France.
    Background/purpose: Following intradermal injection, hyaluronic acid (HA)-based fillers tend to spread within the reticular dermis and to distribute between the dermal fibers. This biointegration is commonly measured qualitatively using histological methods. We developed a "toolbox" consisting of a visual scoring and a semi-automatic image analysis method using internal developed algorithm to quantitate the biointegration of Restylane® in histological sections. Read More

    Gold Nanoparticle-Collagen Gels for Soft Tissue Augmentation.
    Tissue Eng Part A 2018 Mar 20. Epub 2018 Mar 20.
    1 Department of Bioengineering, College of Engineering, University of Missouri , Columbia, Missouri.
    Collagen soft tissue fillers suffer from fast reabsorption, which minimizes their use as a tissue-engineered construct. Extensive cross-linking can be utilized to extend longevity, but changes in microstructure and biomechanics can have deleterious effects. To enhance longevity while still achieving a natural microstructure, gold nanoparticles (AuNPs) were conjugated to fibrilized collagen and homogenized into an injectable form for use as a soft tissue filler. Read More

    High-frequency ultrasound-based differentiation between nodular dermal filler deposits and foreign body granulomas.
    Skin Res Technol 2018 Jan 23. Epub 2018 Jan 23.
    Life-Beauty, Grodzisk Mazowiecki, Poland.
    Background: The number of procedures involving dermal filler injection is still on the rise. Although their safety is improving, not all complications can be avoided. The late complications manifesting as nodules or granulomas pose a particular diagnostic and therapeutic challenge, due to the lack of uniform standards or guidelines. Read More

    Mild Complications or Unusual Persistence of Porcine Collagen and Hyaluronic Acid Gel Following Periocular Filler Injections.
    Ophthalmic Plast Reconstr Surg 2018 Jan 9. Epub 2018 Jan 9.
    David G. Cogan Ophthalmic Pathology Laboratory, and Ophthalmic Plastic and Reconstructive Surgery Service, Department of Ophthalmology of the Massachusetts Eye and Ear Infirmary and the Harvard Medical School, Boston, Massachusetts, U.S.A.
    The purpose of this study was to describe the histopathologic appearance of dermal eyelid fillers that were unexpectedly encountered in ophthalmic plastic surgery samples from patients with mild eyelid disfigurements, and to review eyelid cases with complications that had previously been described in the literature. A retrospective histopathologic study with Alcian blue, elastic, and Masson trichrome stains of 2 cases that were submitted to the Ocular Pathology Department was conducted, and a critical review of previously published cases of the histopathologic characteristics of dermal filler material in the periocular region was also conducted. Two periocular tissue samples were found to contain dermal filler material. Read More

    Cohesive Polydensified Matrix Hyaluronic Acid for the Treatment of Etched-In Fine Facial Lines: A 6-Month, Open-Label Clinical Trial.
    Dermatol Surg 2018 Jan 8. Epub 2018 Jan 8.
    Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California.
    Background: Available hyaluronic acid dermal fillers have unique biophysical properties that influence their clinical utility, longevity, and aesthetic outcomes.

    Objective: To evaluate the effectiveness and durability of a cohesive polydensified matrix hyaluronic acid dermal filler (CPM-HA) for the treatment of etched-in fine facial lines.

    Materials And Methods: Subjects with etched-in fine lines of the forehead, cutaneous lip, melolabial folds, nasolabial folds, and/or radial cheek received treatment with CPM-HA mixed with lidocaine and epinephrine, with an optional touch-up treatment at Week 2, if deemed necessary. Read More

    Role of Nonsurgical Chin Augmentation in Full Face Rejuvenation: A Review and Our Experience.
    Dermatol Surg 2018 Jan 5. Epub 2018 Jan 5.
    Cosmetic Laser Dermatology, San Diego, California.
    Background: The chin is a critical component to the perception of facial attractiveness. Dermal fillers offer a nonsurgical, temporary method of correcting mild to moderate chin retrusion and resorption. Thus far, discussion of this procedure has been largely limited to the plastic surgery and otolaryngology literature. Read More

    Treatment of Soft Tissue Filler Complications: Expert Consensus Recommendations.
    Aesthetic Plast Surg 2018 Apr 5;42(2):498-510. Epub 2018 Jan 5.
    Clínica de Medicina Estética Dra Villanueva, Carrer de Calvet 10, Barcelona, Spain.
    Background: Dermal fillers have been increasingly used in minimally invasive facial esthetic procedures. This widespread use has led to a rise in reports of associated complications. The aim of this expert consensus report is to describe potential adverse events associated with dermal fillers and to provide guidance on their treatment and avoidance. Read More

    Fluorodeoxyglucose activity associated with a cosmetic poly-L-lactide filler: a potential confounder on positron emission tomography and computed tomography.
    Br J Oral Maxillofac Surg 2018 Feb 28;56(2):148-150. Epub 2017 Dec 28.
    Department of Radiology and Nuclear Medicine, Oxford University Hospital NHS Foundation Trust. Electronic address:
    Injectable cosmetic fillers are increasingly popular, but are not often considered as a cause of abnormal findings on imaging. We present a case of poly-L-lactic acid (PLLA) filler associated with 18-fluorodeoxyglucose (FDG) uptake, which had the potential to interfere with staging of a squamous cell carcinoma of the lateral tongue. We characterise the FDG-positron emission tomography/computed tomography (PET/CT) properties of a PLLA dermal filler, Sculptra (Aventis), and highlight its potentially confounding appearance in the staging scans of oncological patients, particularly those with oral tumours. Read More

    Magnetic resonance imaging appearance of foreign-body granulomatous reactions to dermal cosmetic fillers.
    Imaging Sci Dent 2017 Dec 12;47(4):281-284. Epub 2017 Dec 12.
    Division of General Pathology, Department of Stomatology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil.
    Foreign body granulomas can develop after the injection of various cosmetic filling materials into the facial area to flatten wrinkles. Clinically, reactive lesions are easily mistaken for soft-tissue neoplasms or cysts. This report presents a case of foreign body granuloma in a 52-year-old female patient complaining of a painless swelling in the nasolabial region. Read More

    A Cross-sectional Analysis of Adverse Events and Litigation for Injectable Fillers.
    JAMA Facial Plast Surg 2018 May;20(3):207-214
    Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan.
    Importance: Injectable fillers are increasing in popularity as a noninvasive option to address concerns related to facial aging and volume loss. To our knowledge, there have been no large-scale analyses of adverse events and associated litigation related to filler injections.

    Objectives: To determine risks of injectable fillers and analyze factors raised in litigation related to injectable fillers. Read More

    Non-surgical minimally invasive rhinoplasty: tips and tricks from the perspective of a dermatologist.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Dec;26(4):101-103
    Department of Dermatology, School of Medicine, Ufuk University, Ankara, Turkey.
    Introduction: Rhinoplasty is one of the most common aesthetic procedures performed by plastic surgeons all over the world. In recent years, a non-surgical nose job has become the preferred option for most patients and specialists. Minimally invasive techniques already result in high satisfaction rates. Read More

    Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature.
    Immunol Res 2018 Feb;66(1):120-140
    Europe Medical Centre, Barcelona, Spain.
    Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and methacrylate compounds in a Spanish patient cohort. This study is a retrospective analysis of clinical, laboratory, histopathological and follow-up data of 45 cases of patients suffering from late-onset, non-infectious inflammatory/autoimmune disorders related to bioimplants. Read More

    The PET-CT Radiological Appearance of Facial Cosmetic Injections: A Pitfall in the Evaluation of the Oncological Patient.
    Isr Med Assoc J 2017 Nov;19(11):679-681
    Rheumatology Unit, Sheba Medical Center, Tel Hashomer, Israel.
    Background: Facial rejuvenation using different dermal and sub-dermal injectable compounds is a popular cosmetic procedure which may pose a diagnostic dilemma to the radiologist.

    Objectives: To describe the appearance of cosmetic facial fillers on PET-CT.

    Methods: All PET-CT exams performed between January 2015 and May 2017 in which findings suggestive of prior facial filler procedures was evident and where anamnestic confirmation with the patient was possible were reviewed. Read More

    Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé).
    Clin Cosmet Investig Dermatol 2017 8;10:431-440. Epub 2017 Nov 8.
    Behavior, Paris, France.
    Background: The range of fillers currently available for soft-tissue augmentation is constantly expanding. The latest advances in filler technology include collagen biostimulators that exert their esthetic effect by promoting neocollagenesis. One such product is the next-generation collagen biostimulator (Ellansé) that demonstrates properties as yet unseen in soft-tissue fillers. Read More

    Hybrid Complexes of High and Low Molecular Weight Hyaluronans Highly Enhance HASCs Differentiation: Implication for Facial Bioremodelling.
    Cell Physiol Biochem 2017 27;44(3):1078-1092. Epub 2017 Nov 27.
    Background/aims: Adipose-derived Stem Cells (ASCs) are used in Regenerative Medicine, including fat grafting, recovery from local tissue ischemia and scar remodeling. The aim of this study was to evaluate hyaluronan based gel effects on ASCs differentiation and proliferation.

    Methods: Comparative analyses using high (H) and low (L) molecular weight hyaluronans (HA), hyaluronan hybrid cooperative complexes (HCCs), and high and medium cross-linked hyaluronan based dermal fillers were performed. Read More

    Non-aesthetic indications for periocular hyaluronic acid filler treatment: a review.
    Br J Ophthalmol 2018 Jun 16;102(6):725-735. Epub 2017 Nov 16.
    Corneo-plastic Unit, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK.
    Dermal fillers have been in use for many years for aesthetic rejuvenation of the face. More recently, however, fillers have been increasingly used as an alternative to traditional surgical procedures for non-aesthetic indications. These indications include lagophthalmos, eyelid malpositions and orbital volume deficiency. Read More

    Comparing Efficacy and Costs of Four Facial Fillers in Human Immunodeficiency Virus-Associated Lipodystrophy: A Clinical Trial.
    Plast Reconstr Surg 2018 Mar;141(3):613-623
    Madrid, Spain From the Department of Plastic Surgery, University Hospital Gregorio Marañón.
    Background: The objective of this study was to evaluate and compare the safety and effectiveness of four different dermal fillers in the treatment of facial lipoatrophy secondary to human immunodeficiency virus.

    Methods: The authors conducted a clinical trial including 147 patients suffering from human immunodeficiency virus-induced lipoatrophy treated with Sculptra (poly-L-lactic acid), Radiesse (calcium hydroxylapatite), Aquamid (polyacrylamide), or autologous fat. Objective and subjective changes were evaluated during a 24-month follow-up. Read More

    A Novel and More Aesthetic Injection Pattern for Malar Cheek Volume Restoration.
    Aesthetic Plast Surg 2018 Feb 24;42(1):197-200. Epub 2017 Oct 24.
    Galderma Laboratories, L.P, 14501 N. Freeway Rd, Fort Worth, TX, 76177, USA.
    The loss of superior midface contour and projection can be corrected with the use of injectable hyaluronic acid (HA) dermal fillers, however, the most frequently used injection pattern employs a technique which was originally designed for malar implant surgery. Here we describe a novel injection pattern for restoring facial contours with a HA dermal filler inspired by traditional make-up artistry, which includes greater superolateral positioning of injection sites. Importantly, this technique helps injectors avoid creating an excess of volume in the anterior portion of the malar complex. Read More

    Randomized, Evaluator-Blinded Study Comparing Safety and Effect of Two Hyaluronic Acid Gels for Lips Enhancement.
    Dermatol Surg 2018 Feb;44(2):261-269
    Galderma, Uppsala, Sweden.
    Background: Hyaluronic acid (HA) fillers may differ in terms of gel characteristics and ease of use and it is of interest whether this might affect safety and duration of effect.

    Objective: To compare the long-term safety and effect of 2 HA fillers produced by 2 different technologies for lip enhancement.

    Materials And Methods: Subjects with very thin to moderately thick lips were randomized and treated with HA-RK (N = 31) or HA-JV (N = 29) to improve lip fullness by ≥ 1 grade on a 5-point scale, using a maximum of 3 mL of product. Read More

    Polyalkylimide: A Nonstable Filler Over Time.
    Dermatol Surg 2018 Apr;44(4):563-567
    Department of Pathology, Academic Hospital, Utrecht, the Netherlands.
    Background: Polyalkylimide hydrogel is supposed to be a permanent, biocompatible implant. However, years after subcutaneous implantation clinical complications are seen.

    Objective: To increase the understanding of the changes that occur over time in this subdermal implanted filler. Read More

    Hyaluronic Acid Gel With (HARRL) and Without Lidocaine (HAJU) for the Treatment of Moderate-to-Severe Nasolabial Folds: A Randomized, Evaluator-Blinded, Phase III Study.
    Dermatol Surg 2018 Apr;44(4):549-556
    Galderma Laboratories, L.P., Fort Worth, Texas.
    Background: Hyaluronic acid (HA) dermal fillers are frequently used to correct or smooth facial wrinkles and folds such as nasolabial folds.

    Objective: To compare the efficacy and safety of 2 HA gels, formulated by 2 different manufacturing processes: XpresHAn Technology (HARRL [with lidocaine]) and Hylacross technology (HAJU-a comparator product without lidocaine).

    Patients And Methods: One hundred seventy subjects with bilateral nasolabial folds rated as moderate or severe, according to the Wrinkle Severity Rating Scale (WSRS), received injections of HARRL in the nasolabial folds on one side of the face and HAJU on the other side. Read More

    Cohesion of Hyaluronic Acid Fillers: Correlation Between Cohesion and Other Physicochemical Properties.
    Dermatol Surg 2018 Apr;44(4):557-562
    Both authors are affiliated with the Research & Development, Galderma, Uppsala, Sweden.
    Background: There are several published articles on characterization of fillers, describing methods for both chemical and physicochemical characterization. Recently a lot of focus has been on the development of methods for measuring cohesion of hyaluronic acid (HA) fillers.

    Objective: The aim of this study is to investigate and compare the drop-weight method and the correlation between cohesion and other physicochemical properties using a variety of HA fillers. Read More

    [Body experience and self-esteem after minimally invasive skin rejuvenation : Study of female patients using botulinum toxin A and/or dermal fillers].
    Hautarzt 2017 Dec;68(12):959-967
    , Leipziger Str. 44, 39120, Magdeburg, Deutschland.
    Background: More and more people worldwide and also in Germany are using botulinum toxin type A (BoNT-A) and hyaluronic acid injections for skin rejuvenation.

    Objective: Study on body image and self-esteem of women with BoNT-A and/or hyaluronic acid filler treatment.

    Material And Methods: A total of 145 women who requested BoNT-A and/or hyaluronic acid injections completed a survey comprised of the body dysmorphic disorder questionnaire, the Rosenberg self-esteem scale and questionnaires on the attitudes and motives on measures for optimization of the body and demographic features. Read More

    Tissue Expansion Using Hyaluronic Acid Filler for Single-Stage Ear Reconstruction: A Novel Concept for Difficult Areas.
    Aesthet Surg J 2017 Oct;37(10):1085-1097
    Private practice, Malvern, Victoria, Australia. Section of Plastic and Reconstructive Surgery, University of Chicago Medical Center, Chicago, IL, USA. Private practice, Malvern, Victoria, Australia.
    Background: Auricular reconstruction is one of the most challenging procedures in plastic surgery. An adequate skin envelope is essential for cartilage framework coverage, yet few good options exist without additional surgery. We propose a novel method for minimally invasive tissue expansion, using hyaluronic acid (HA) filler to allow for single-stage ear reconstruction. Read More

    The Role of Injectables in Aesthetic Surgery: Financial Implications.
    Aesthet Surg J 2017 10;37(9):1039-1043
    Department of Plastic Surgery, Cleveland Clinic Foundation, Cleveland, OH.
    Background: The plastic surgeon competes with both core and noncore physicians and surgeons for traditional cosmetic procedures. In 2007, the American Society for Aesthetic Plastic Surgery (ASAPS) and the American Society of Plastic Surgeons (ASPS) joined efforts to form a Cosmetic Medicine Task Force to further analyze this trend.

    Objectives: Our objective is to document and quantify the patient capture and total collections generated in a single surgeon's practice exclusive from Botulinum Toxin A and filler injections over a 10-year period. Read More

    The Efficacy of Vibration Anesthesia on Reducing Pain Levels During Lip Augmentation: Worth the Buzz?
    Aesthet Surg J 2017 10;37(9):1044-1048
    Koç University School of Medicine, Istanbul, Turkey.
    Background: Lip augmentation procedures have increased drastically in the last years as patients seek to enhance the shape and size of their lips with dermal fillers. One of the main concerns faced with these procedures is the pain inflicted through injections. On the other hand, many different techniques have been introduced for the reduction of pain while performing office-based minimal invasive procedures. Read More

    A Histopathologic Diagnosis of Vascular Occlusion After Injection of Hyaluronic Acid Filler: Findings of Intravascular Foreign Body and Skin Necrosis.
    Aesthet Surg J 2017 Oct;37(9):NP102-NP108
    Private practice Kanagawa, Japan.
    Before injecting hyaluronic acid (HA) filler into high-risk zones of the face, considerable caution must be exercised, including careful selection of the most appropriate filler, volume, and injection technique. Rare but severe adverse events have occurred during and after injection of HA filler in or around the periorbital region, such as skin necrosis and blindness. In the present case, involving a 57-year-old woman, approximately 0. Read More

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