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    758 results match your criteria Dermal Fillers

    1 OF 16

    Non-aesthetic indications for periocular hyaluronic acid filler treatment: a review.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Corneo-plastic Unit, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, United Kingdom.
    Dermal fillers have been in use for many years for aesthetic rejuvenation of the face. More recently, however, fillers have been increasingly used as an alternative to traditional surgical procedures for non-aesthetic indications. These indications include lagophthalmos, eyelid malpositions and orbital volume deficiency. Read More

    "Comparing efficacy and costs of four facial fillers in HIV-associated lipodystrophy: a clinical trial."
    Plast Reconstr Surg 2017 Nov 8. Epub 2017 Nov 8.
    1. Department of Plastic Surgery, University Hospital Gregorio Marañón; Madrid, Spain.
    Background: The objective was to evaluate and compare safety and effectiveness of four different dermal fillers in the treatment of facial lipoatrophy secondary to Human Immunodeficiency Virus (HIV).

    Methods: We conducted a clinical trial including 147 patients suffering from HIV-induced lipoatrophy treated with Sculptra® (poly-L-lactic acid), Radiesse® (calcium hydroxylapatite), Aquamid® (polyacrylamide) or autologous fat. Objective and subjective changes were evaluated during a 24-monthfollow-up. Read More

    A Novel and More Aesthetic Injection Pattern for Malar Cheek Volume Restoration.
    Aesthetic Plast Surg 2017 Oct 24. Epub 2017 Oct 24.
    Galderma Laboratories, L.P, 14501 N. Freeway Rd, Fort Worth, TX, 76177, USA.
    The loss of superior midface contour and projection can be corrected with the use of injectable hyaluronic acid (HA) dermal fillers, however, the most frequently used injection pattern employs a technique which was originally designed for malar implant surgery. Here we describe a novel injection pattern for restoring facial contours with a HA dermal filler inspired by traditional make-up artistry, which includes greater superolateral positioning of injection sites. Importantly, this technique helps injectors avoid creating an excess of volume in the anterior portion of the malar complex. Read More

    Hyaluronic Acid Gel With (HARRL) and Without Lidocaine (HAJU) for the Treatment of Moderate-to-Severe Nasolabial Folds: A Randomized, Evaluator-Blinded, Phase III Study.
    Dermatol Surg 2017 Oct 20. Epub 2017 Oct 20.
    *Private Practice, Boca Raton, Florida; †Total Skin and Beauty Dermatology Center, Birmingham, Alabama; ‡Skin Care and Laser Physicians of Beverly Hills, Los Angeles, California; §The Center for Dermatology, Cosmetic, & Laser Surgery, Mt Kisco, New York; ‖Sadick Dermatology and Sadick Research Group, New York, New York; ¶Galderma Laboratories, L.P., Fort Worth, Texas.
    Background: Hyaluronic acid (HA) dermal fillers are frequently used to correct or smooth facial wrinkles and folds such as nasolabial folds.

    Objective: To compare the efficacy and safety of 2 HA gels, formulated by 2 different manufacturing processes: XpresHAn Technology (HARRL [with lidocaine]) and Hylacross technology (HAJU-a comparator product without lidocaine).

    Patients And Methods: One hundred seventy subjects with bilateral nasolabial folds rated as moderate or severe, according to the Wrinkle Severity Rating Scale (WSRS), received injections of HARRL in the nasolabial folds on one side of the face and HAJU on the other side. Read More

    [Body experience and self-esteem after minimally invasive skin rejuvenation : Study of female patients using botulinum toxin A and/or dermal fillers].
    Hautarzt 2017 Oct 20. Epub 2017 Oct 20.
    , Leipziger Str. 44, 39120, Magdeburg, Deutschland.
    Background: More and more people worldwide and also in Germany are using botulinum toxin type A (BoNT-A) and hyaluronic acid injections for skin rejuvenation.

    Objective: Study on body image and self-esteem of women with BoNT-A and/or hyaluronic acid filler treatment.

    Material And Methods: A total of 145 women who requested BoNT-A and/or hyaluronic acid injections completed a survey comprised of the body dysmorphic disorder questionnaire, the Rosenberg self-esteem scale and questionnaires on the attitudes and motives on measures for optimization of the body and demographic features. Read More

    The Efficacy of Vibration Anesthesia on Reducing Pain Levels During Lip Augmentation: Worth the Buzz?
    Aesthet Surg J 2017 10;37(9):1044-1048
    Koç University School of Medicine, Istanbul, Turkey.
    Background: Lip augmentation procedures have increased drastically in the last years as patients seek to enhance the shape and size of their lips with dermal fillers. One of the main concerns faced with these procedures is the pain inflicted through injections. On the other hand, many different techniques have been introduced for the reduction of pain while performing office-based minimal invasive procedures. Read More

    Hyaluronic acid gel filler for nipple enhancement following breast reconstruction.
    Cutis 2017 Aug;100(2):107-109
    Galderma Laboratories, LP, Fort Worth, Texas, USA.
    The loss of the 3-dimensional contour of the nipple-areola complex (NAC) following surgical breast reconstruction is a technical challenge for the physician and a psychological burden for many breast cancer patients. The use of injectable dermal fillers to enhance nipple projection is a simple noninvasive procedure with immediate and adjustable volume results that positively impact patient satisfaction. The utility and safety of injectable hyaluronic acid (HA) gel make it an ideal filler for restoring the natural feel and contour to the delicate structure of the NAC and in some cases may represent a simple solution following breast reconstruction. Read More

    Lifting the Lower Face With an Absorbable Polydioxanone (PDO) Thread.
    J Drugs Dermatol 2017 Sep;16(9):932-934
    Traditional rejuvenation techniques include chemical peels, rhytidectomy of the skin, laser resurfacing, injection of dermal fillers and neurotoxins, and invasive surgical procedures. Patients with brow ptosis, jowl formation, and deepening nasolabial folds currently seek antiaging procedures with no incisions and minimal downtime such as thread-lifting with barbed sutures. The present report describes a case in which polydioxanone threads were used to lift the lower third of a patient's face. Read More

    Factors Affecting the Rheological Measurement of Hyaluronic Acid Gel Fillers.
    J Drugs Dermatol 2017 Sep;16(9):876-882
    Background: With the number of available dermal fillers increasing, so is the demand for scientifically based comparisons, often with rheological properties in focus. Since analytical results are always influenced by instrument settings, consensus on settings is essential to make comparison of results from different investigators more useful.

    Objective: Preferred measurement settings for rheological analysis of hyaluronic acid (HA) fillers are suggested, and the reasoning behind the choices is presented by demonstrating the effect of different measurement settings on select commercial HA fillers. Read More

    Precision in Dermal Filling: A Comparison Between Needle and Cannula When Using Soft Tissue Fillers.
    J Drugs Dermatol 2017 Sep;16(9):866-872
    Background: Precise implantation of soft tissue fillers to treat the signs of aging is crucial for patient safety and the best aesthetic outcome. Injections are performed commonly with either needles or cannulas, but quantitative comparative data on precise implantation are still elusive.

    Methods: Ten fresh-frozen cephalic foreheads (9 male, 1 female) were injected with radiopaque material using both needles and cannulas. Read More

    Atypical Facial Filler Granuloma: Comparative Histologic Analysis with Paraffinoma.
    Arch Craniofac Surg 2016 Sep 23;17(3):169-172. Epub 2016 Sep 23.
    Department of Plastic and Reconstructive Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
    Dermal fillers are generally accepted as safe and well-tolerable cosmetic tools. However, adverse reactions have been reported in the literature. Here, we present a case of atypical facial filler granuloma and compare its histologic features with those of the classic paraffinoma. Read More

    [Benefits of volumetric to facial rejuvenation. Part 2: Dermal fillers].
    Ann Chir Plast Esthet 2017 Oct 12;62(5):550-559. Epub 2017 Sep 12.
    Hôpital américain de Paris, 63, boulevard Victor-Hugo, 92200 Neuilly-sur-Seine, France; 90, boulevard Flandrin, 75116 Paris, France.
    Injectable substances known as fillers are used to palliate age-related atrophy and ptosis, and for their so-called "pseudo-lifting" action. They do not replace face and neck lift, but allow it to be postponed or, when injected after surgical lifting, make the result durable. Hyaluronic acid has a predominant and unchallenged place among fillers, well ahead of poly-L-lactic acid or calcium hydroxyapatite. Read More

    Small-Particle Hyaluronic Acid Gel Treatment of Photoaged Hands.
    Dermatol Surg 2017 Sep 4. Epub 2017 Sep 4.
    *Skin Laser & Surgery Specialists of New York and New Jersey, Hackensack, New Jersey; †Icahn School of Medicine at Mt. Sinai, New York, New York.
    Background: Aging hands tend to lose subcutaneous volume resulting in prominence of the underlying vessels, tendons, and bone contributing to an aged appearance. Dermal fillers have been successfully used to improve the appearance of the aging dorsal hand.

    Objective: The objective is to evaluate the safety and efficacy of a small-particle hyaluronic acid (SPHA) injectable gel for the treatment of photoaged volume loss of the hands. Read More

    Hyaluronic acid-hydroxyapatite nanocomposite hydrogels for enhanced biophysical and biological performance in a dermal matrix.
    J Biomed Mater Res A 2017 Dec 19;105(12):3315-3325. Epub 2017 Sep 19.
    Department of Materials Science and Engineering, Seoul National University, Seoul, South Korea.
    A hyaluronic acid (HAc)-hydroxyapatite (HAp) nanocomposite (HAc-nanoHAp) hydrogel was fabricated through an in situ precipitation process for mechanical and biological enhancement as a soft tissue augmentation product. In this study, these composite hydrogel fillers were analyzed from three different perspectives and compared with pure HAc hydrogel for soft tissue augmentation application: (1) rheological behaviors, (2) in vivo lateral diffusion under mouse skin, and (3) wrinkle improvement in a photo-aged mouse model. HAc-nanoHAp provided great improvement to wrinkles because of its higher stiffness and gel cohesiveness in comparison with that of pure HAc. Read More

    Facial Soft Tissue Augmentation in Males: An Anatomical and Practical Approach.
    Dermatol Surg 2017 Nov;43 Suppl 2:S131-S139
    *Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; †Department of Dermatology, Weill Cornell Medicine, New York, New York; ‡Department of Dermatology, UCLA Medical Center, Los Angeles, California; §Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
    Background: Soft tissue augmentation is increasingly being performed to treat male facial aging.

    Objective: To review anatomical consideration specific for the male face and define an approach to male soft tissue augmentation that creates harmonious and natural results.

    Conclusion: Addressing aesthetic concerns in the upper face, midface, and lower face should be performed in concert with a combinatorial and pan facial approach. Read More

    A Prospective, Open-Label Study of Hyaluronic Acid-Based Filler With Lidocaine (VYC-15L) Treatment for the Correction of Infraorbital Skin Depressions.
    Dermatol Surg 2017 Oct;43(10):1271-1280
    *Centre Chirurgical Niforos, Lyon, France; †The Gatehouse, Cheshire, United Kingdom; ‡SkinConcept, Munich, Germany; §La Jouvence, Neuchâtel, Switzerland; ‖Private Practice, Milan, Italy; ¶Peloton Advantage, Parsippany, New Jersey; #Allergan Plc, Marlow, United Kingdom.
    Background: Infraorbital skin depressions are one of the most troublesome facial areas for aesthetically aware patients.

    Objective: Evaluate effectiveness and safety of Juvéderm Volbella with Lidocaine (VYC-15L; Allergan plc, Dublin, Ireland) for correction of bilateral infraorbital depressions.

    Methods: In this 12-month, prospective, uncontrolled, open-label study, subjects aged ≥18 years with infraorbital depressions rated ≥1 on the Allergan Infra-oRbital Scale (AIRS) received injections of VYC-15L with optional touch-up treatment on Day 14. Read More

    Hyaluronidase: Understanding Its Properties and Clinical Application for Cosmetic Injection Adverse Events.
    Plast Surg Nurs 2017 Jul/Sep;37(3):109-111
    Jeanine Harrison, BScN, MN, RN-EC, NP, is Nurse Practitioner, TH Medical Aesthetics, Thornhill, Ontario, Canada. Oriol Rhodes RN, BAS, MBA, is Registered Nurse, TH Medical Aesthetics, Thornhill, Ontario, Canada.
    The recent global consensus on the management of cosmetic aesthetic injectable complications from hyaluronic acid (HA) has increased the focus on the use of hyaluronidase more than ever before (M. Signorini et al., 2016). Read More

    Assessment of the Efficacy and Safety of Hyaluronic Acid Gel Injection in the Restoration of Fullness of the Upper Lips.
    J Cutan Aesthet Surg 2017 Apr-Jun;10(2):101-105
    Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
    Background And Aim: Lips have a significant role in face aesthetic perception, and lip augmentation is one of the most commonly requested aesthetic procedures. Non-permanent dermal fillers, such as hyaluronic acid (HA), are used for augmenting the lips. This article presents the results of Phase II, before - after designed study, assessing the safety and efficacy of a soft tissue HA filler, for upper lip augmentation. Read More

    Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Lower Face.
    Plast Reconstr Surg 2017 Sep;140(3):393e-404e
    São Paulo, Brazil; Singapore; South Yarra, Melbourne, Victoria, Australia; and Birmingham, Ala. From the Clinica Dr. Maurício de Maio; the Woffles Wu Aesthetic Surgery and Laser Centre; the Dermatology Institute of Victoria; and the Total Skin and Beauty Dermatology Center.
    This third article of a three-part series addresses techniques and recommendations for aesthetic treatment of the lower face. The lower face is considered an advanced area for facial aesthetic treatment. In this region, soft-tissue fillers play a more important role than neuromodulators and should be used first to provide structure and support before neuromodulators are considered for treatment of dynamic lines. Read More

    Dermal filler-associated malar edema: Treatment of a persistent adverse effect.
    Orbit 2017 Aug 24:1-3. Epub 2017 Aug 24.
    a Department of Ophthalmology , Palmetto Health University of South Carolina Medical Group , Columbia , South Carolina , USA.
    A 72-year-old Caucasian female presented for evaluation of bilateral lower eyelid "fluid filled" bags that had been present and slowly worsening for 7 years. She reported a history of lower eyelid blepharoplasty in her 40s, as well as hyaluronic acid tear trough fillers 8 years prior to presentation. Her malar edema completely resolved following injection of hyaluronidase. Read More

    A review of hydrolifting: A new modality for skin rejuvenation.
    J Cosmet Laser Ther 2017 Jul 28:1-6. Epub 2017 Jul 28.
    b Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Republic of Korea.
    Background: Hydrolifting is a newly developed modality of skin rejuvenation, which enhances overall facial volume augmentation and recovers skin thickness through multi-pass HA injection. Although it is commonly performed, only a few articles have reported on the rejuvenating effects of hydrolifting. Moreover, clear protocols and possible mechanisms of the procedure have not been elucidated. Read More

    Anatomic Study of Ophthalmic Artery Embolism Following Cosmetic Injection.
    J Craniofac Surg 2017 Sep;28(6):1578-1581
    Department of Plastic Surgery and Reconstructive Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
    Introduction: Cosmetic injections of dermal fillers or fat could cause ophthalmic artery embolism and even blindness, the high-risk regions of which are considered glabellar, nasal dorsum, and nasolabial fold. Understanding anatomy of the related arteries is important for a physician to safely perform filler injections. To investigate the mechanisms of ophthalmic artery embolism following the injections, cadaver anatomy was studied. Read More

    The increasing relevance of biofilms in common dermatological conditions.
    J Dermatolog Treat 2017 Aug 9:1-6. Epub 2017 Aug 9.
    b Department of Dermatologic Surgery and Laser Unit, St. Thomas' Hospital , St. John's Institute of Dermatology , London , UK.
    Background: Biofilms are diverse groups of microorganisms encased in a self-produced matrix that offers protection against unfavorable conditions and antibiotics.

    Methods: We performed a literature search using the MEDLINE electronic database. Only original articles published in English were considered for review. Read More

    Facial Assessment and Injection Guide for Botulinum Toxin and Injectable Hyaluronic Acid Fillers: Focus on the Upper Face.
    Plast Reconstr Surg 2017 Aug;140(2):265e-276e
    São Paulo, Brazil; Montreal, Quebec, Canada; Milan, Italy; and Boca Raton, Fla. From the Clinica Dr. Maurício de Maio; The Westmount Institute of Plastic Surgery; Istituto Dermatologico Europeo; and Aesthetic Eyelid Plastic Surgery.
    Techniques for the administration of injectable fillers and neuromodulators for facial aesthetic rejuvenation and enhancement continue to evolve. As the number of physicians with limited experience in providing aesthetic treatments expands, the need for guidance and training from more experienced injectors has become apparent. The use of a slow, careful, and methodical injection technique is imperative in all treatment settings and for all facial areas. Read More

    Adipose‑derived stem cells and hyaluronic acid based gel compatibility, studied in vitro.
    Mol Med Rep 2017 Oct 21;16(4):4095-4100. Epub 2017 Jul 21.
    Department of Pathophysiology, China Medical University, Heping, Shenyang, Liaoning 110001, P.R. China.
    Minimally invasive aesthetic and cosmetic procedures have increased in popularity. Injectable dermal fillers provide soft tissue augmentation, improve facial rejuvenation and wrinkles, and correct tissue defects. To investigate the use of adipose‑derived stem cells integrated with a hyaluronic acid based gel as a dermal filler, the present study used cytotoxicity studies, proliferation studies, adipogenic and osteogenic differentiation, apoptosis assays and scanning electron microscopy. Read More

    Skin Necrosis with Oculomotor Nerve Palsy Due to a Hyaluronic Acid Filler Injection.
    Arch Plast Surg 2017 Jul 15;44(4):340-343. Epub 2017 Jul 15.
    Department of Plastic and Reconstructive Surgery, Busan Baik Hospital, InJe University School of Medicine, Busan, Korea.
    Performing rhinoplasty using filler injections, which improve facial wrinkles or soft tissues, is relatively inexpensive. However, intravascular filler injections can cause severe complications, such as skin necrosis and visual loss. We describe a case of blepharoptosis and skin necrosis caused by augmentation rhinoplasty and we discuss the patient's clinical progress. Read More

    RESULTS OF MINIMAL INVASIVE TREATMENT IN LOCALIZED ACQUIRED CUTIS LAXA TYPE 1 AND TYPE 2 - CASE REPORT AND DISCUSSION.
    Georgian Med News 2017 Jun(267):17-19
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
    Cutis laxa is a disease of premature ageing. While the congenital type is characterized by mutations of genes involved in extracellular matrix turnover, acquired cutis laxa is a rare disease that can be induced by a variety of exogenous factors. We present a case of acquired type 2 cutis laxa of the neck due to excessive exposure to natural sunlight and a type 1 facial acquired cutis laxa, both significantly improved by minor invasive procedures. Read More

    Effectiveness evaluation of two volumizing hyaluronic acid dermal fillers in a controlled, randomized, double-blind, split-face clinical study.
    Clin Cosmet Investig Dermatol 2017 29;10:239-247. Epub 2017 Jun 29.
    Prager & Partner Dermatologische Praxis, Hamburg, Germany.
    Background: Enhancement of the midface can be achieved with volumizing hyaluronic acid (HA) fillers.

    Objective: The objective of this study was to compare the safety and effectiveness of Cohesive Polydensified Matrix(®) 26 mg/mL HA gel (CPM-26) and Vycross(®) 20 mg/ml HA gel (VYC-20) in a controlled, randomized, evaluator-blind, split-face clinical study.

    Patients And Methods: Subjects with moderate-to-severe malar volume loss on the Merz Aesthetics Scale (MAS) received CPM-26 on one side and VYC-20 on the contralateral side of the face. Read More

    Granulomatous reaction to hyaluronic acid filler material in oral and perioral region: A case report and review of literature.
    J Cosmet Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    Faculdade de Odontologia, Departamento de Clínica, Patologia e Cirurgia Odontológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
    The use of cosmetic fillers agents in orofacial region has become more often used for esthetic concern. Although adverse effects are rare, some patients may develop foreign body reaction to such fillers. Hyaluronic acid (HA) is a biomaterial in the spotlight, because it is normally present in several tissues of human body. Read More

    Device Safety Implications of the Clinical Data Leading to US Food and Drug Administration Approval of Soft-Tissue Fillers: A Systematic Review.
    JAMA Facial Plast Surg 2017 Sep;19(5):421-429
    Department of Dermatology, McGaw Medical Center, Northwestern University, Chicago, Illinois.
    Importance: The US Food and Drug Administration (FDA) recently issued a safety warning regarding soft-tissue fillers (STFs) based on the risk of blindness and facial necrosis.

    Objective: To examine the quality of evidence leading to FDA approval of STFs.

    Evidence Review: All original approvals for STFs were mined using the publicly available FDA database. Read More

    Effect of platelet reach plasma on fibroblast primary culture: gene expression evaluation.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):241-246
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
    To correct skin imperfections, aesthetic medicine today makes use of injectable dermal fillers that allow filling skin by increasing the volume of soft tissue. Currently, there are many fillers usable for their excellent biocompatibility and low allergic reactions that ensure good results and good compliance. Among these, the most widely used filler is Human Plasma, obtained by centrifugation from patient blood and processed through cycles of centrifugation and heating, until it becomes a gel. Read More

    Demarcative Necrosis Along Previous Laceration Line After Filler Injection.
    J Craniofac Surg 2017 Jul;28(5):e481-e482
    *Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National, University †Research Institute of Clinical Medicine-Biomedical Research Institute of Chonbuk National, University Hospital, Jeonju, Republic of Korea.
    In recent years, fillers have been widely used for soft tissue augmentation. Although they are generally considered to be safe, many complications have been reported to date. Nose and nasolabial fold augmentations with fillers can lead to an implementation of nasal skin necrosis, possibly caused by intravascular embolism and/or extravascular compression. Read More

    The Classification and Prognosis of Periocular Complications Related to Blindness following Cosmetic Filler Injection.
    Plast Reconstr Surg 2017 Jul;140(1):61-64
    Seongnam-si, Gyeonggi-do, Republic of Korea From the Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University.
    Common side effects during hyaluronic acid filler injections are typically mild and reversible, but several reports of blindness have received attention. The present study focused on orbital symptoms combined with blindness, aiming to classify affected patients and predict their disease course and prognosis. From September of 2012 to August of 2015, nine patients with vision loss after filler injection were retrospectively reviewed. Read More

    Minimal recovery time needed to return to social engagement following nasolabial fold correction with hyaluronic acid fillers produced with XpresHAn technology.
    Clin Cosmet Investig Dermatol 2017 14;10:229-238. Epub 2017 Jun 14.
    Medical Affairs, Galderma Laboratories, L.P., Fort Worth, TX, USA.
    Introduction: The appeal of hyaluronic acid fillers for facial soft tissue augmentation is attributable to both an immediate aesthetic effect and relatively short recovery time. Although recovery time is an important posttreatment variable, as it impacts comfort with appearance and perceived treatment benefit, it is not routinely evaluated. Natural-looking aesthetic outcomes are also a primary concern for many patients. Read More

    Prospective, Split-Face, Randomized, Long-Term Blinded Objective Comparison of the Performance and Tolerability of Two New Hyaluronic Acid Fillers.
    Dermatol Surg 2017 Jun 6. Epub 2017 Jun 6.
    *Clinique REMUSAT, Paris, France;†Private Practice, Paris, France;‡Private Practice, Paris, France;§Private Practice, Paris, France;¶Fondation Rothschild, Paris, France;‖Private Practice, Paris, France;**GREDECO, Paris, France;††Société VERTICAL, Paris, France;‡‡Laboratoires FILORGA, Paris, France.
    Background: There are requirements for long-term, objective comparisons of hyaluronic acid (HA) dermal fillers.

    Objective: To compare efficacy and tolerability of ART FILLER Universal (AFU) and ART FILLER Fine lines (AFFL) with the existing HA fillers for the treatment of nasolabial folds and crow's feet.

    Materials And Methods: Prospective, randomized, rater- and patient-blind, split-face comparison of AFU with JUVEDERM Ultra 3 (JUV) and AFFL with FIRST LINES PureSense (FLPS). Read More

    Three-Dimensional Imaging as a Novel Method of Evaluating the Longevity of Hyaluronic Acid Fillers in a Mouse Model.
    Dermatol Surg 2017 08;43(8):1108-1112
    Department of Dermatology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, South Korea, Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea Department of Dermatology, Chung-Ang University College of Medicine, Seoul, South Korea.

    Antibacterial SnO2 nanorods as efficient fillers of poly(propylene fumarate-co-ethylene glycol) biomaterials.
    Mater Sci Eng C Mater Biol Appl 2017 Sep 20;78:806-816. Epub 2017 Apr 20.
    Airbus Operations S. L., John Lennon s/n, 28906 Getafe, Madrid, Spain.
    Antibacterial and biocompatible SnO2 nanorods have been easily synthesized through a hydrothermal process with the aid of a cationic surfactant, and incorporated as nanoreinforcements in poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) copolymer crosslinked with N-vinyl-pyrrolidone (NVP) by sonication and thermal curing. The nanorods were randomly and individually dispersed inside the P(PF-co-EG) network, and noticeably increased the thermal stability, hydrophilicity, degree of crystallinity, protein absorption capability as well as stiffness and strength of the matrix, whilst decreased its level of porosity and biodegradation rate. More importantly, the resulting nanocomposites retained adequate rigidity and strength after immersion in a simulated body fluid (SBF) at 37°C. Read More

    Cheek and Chin Implants to Enhance Facelift Results.
    Facial Plast Surg 2017 Jun 1;33(3):279-284. Epub 2017 Jun 1.
    Facial Plastic Surgery Associates, 6655 Travis Street, Suite 900, Houston, Texas.
    The traditional rhytidectomy addresses facial and neck aging as it relates to soft tissue laxity. The modern volumetric facelift provides optimal results by addressing not only skin laxity but also the loss of volume secondary to tissue atrophy and bony resorption. While multiple techniques including fat grafting, dermal fillers, and tissue resuspension are used to correct the tissue loss, alloplastic midface augmentation remains the most permanent method. Read More

    Impending Facial Skin Necrosis and Ocular Involvement After Dermal Filler Injection: A Case Report.
    Aesthetic Plast Surg 2017 Oct 31;41(5):1198-1201. Epub 2017 May 31.
    Plastic Surgery Unit, Istituto Nazionale dei Tumori, Milan, Italy.
    Demand for non-surgical rejuvenating procedure is constantly increasing due to the aging population, increasing expense of aesthetics and beauty procedures, introduction of new applications and rising demand for noninvasive aesthetic procedures over surgical procedures. Skin necrosis is a rare but severe potential complication. It is caused by impediment of the blood supply to the skin area by compression and/or obstruction of the vessel with filler material, and/or direct injury to the vessel. Read More

    A Two-Phase Pilot Study to Evaluate the Safety and Tolerability of an In Situ Polymerizing Collagen.
    Dermatol Surg 2017 Sep;43(9):1115-1119
    *London Bridge Plastic & Aesthetic Clinic, London, United Kingdom; †EternoGen, LLC, Columbia, Missouri.
    Background: Demand for collagen-based fillers has declined primarily because of limited long-term clinical benefit and the introduction of hyaluronic acid compositions. In situ polymerizing collagen is a noncrosslinked solution of porcine collagen containing a collagenase shield that undergoes fibrillogenesis on injected into tissues forming a natural matrix.

    Objective: Conduct a prospective, single-center, dual-phase open-label study in 8 subjects to evaluate the safety, tolerability, and efficacy of the porcine collagen composition. Read More

    Filler Nodules: Inflammatory or Infectious? A Review of Biofilms and Their Implications on Clinical Practice.
    Dermatol Surg 2017 May 22. Epub 2017 May 22.
    *SkinCare Physicians, Chestnut Hill, Massachusetts;†Department of Dermatology, Boston Medical Center, Boston, Massachusetts.
    Background: The numbers of minimally invasive cosmetic procedures performed in the United States have steadily increased each year. Concurrently, the rates of filler complications have also increased. Delayed filler reactions and granulomas have recently been attributed to biofilm infections. Read More

    A Novel Needle Structure that Can Avoid Intravascular Injection of Any Filler.
    Plast Reconstr Surg Glob Open 2017 Apr 20;5(4):e1285. Epub 2017 Apr 20.
    Clinical Department, Awesomemed Dermatology Clinic, Hsinchu, Taiwan; and Department of Medical Education, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.
    With increasing use of dermal fillers, more and more adverse effects are reported. The most devastating one is intravascular injection. We propose a novel needle prototype that allows physicians to prevent intravascular injection. Read More

    The Kinetics of Reversible Hyaluronic Acid Filler Injection Treated With Hyaluronidase.
    Dermatol Surg 2017 Jun;43(6):841-847
    *Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; †Marmur Medical, New York, New York; ‡Department of Dermatology, The Mount Sinai Hospital, New York, New York.
    Background: Hyaluronidase is an enzyme capable of dissolution of hyaluronic acid (HA). There is a lack of evidence-based research defining time- and concentration-dependent reversal of HA filler using hyaluronidase.

    Objective: To explore the efficacy of different concentrations of hyaluronidase in digesting commercially available HA-based reversible fillers-Belotero Balance (BEL), Juvederm Ultra XC (JUVXC), Juvederm Ultra Plus (JUVX+), Juvederm Voluma XC (JUVV), Restylane-L (RESL), Restylane Silk (RESS), and Perlane/Restylane Lyft (RESLYFT). Read More

    Facial Danger Zones: Techniques to Maximize Safety during Soft-Tissue Filler Injections.
    Plast Reconstr Surg 2017 May;139(5):1103-1108
    Dallas, Texas; and San Francisco, Calif. From the Dallas Plastic Surgery Institute and Sieber Plastic Surgery.
    Given the short recovery and immediate results, facial fillers have become a popular alternative to surgical rejuvenation of the face. Reported complications arising from facial filler injections include erythema, tissue loss, blindness, stroke, and even death. In this article, the authors describe their anatomically based techniques to minimize risk and maximize safety when injecting in the facial danger zones, including the glabella/brow, temporal region, perioral region, nasolabial fold, nose, and infraorbital region. Read More

    Preventing the Complications Associated with the Use of Dermal Fillers in Facial Aesthetic Procedures: An Expert Group Consensus Report.
    Aesthetic Plast Surg 2017 Jun 14;41(3):667-677. Epub 2017 Apr 14.
    Clínica de Medicina Estética Dra Villanueva, Carrer de Calvet 10, Barcelona, Spain.
    Background: The use of dermal fillers in minimally invasive facial aesthetic procedures has become increasingly popular of late, yet as the indications and the number of procedures performed increase, the number of complications is also likely to increase. Paying special attention to specific patient characteristics and to the technique used can do much to avoid these complications. Indeed, a well-trained physician can also minimize the impact of such problems when they do occur. Read More

    Mid-Face Volumization With Hyaluronic Acid: Injection Technique and Safety Aspects from a Controlled, Randomized, Double-Blind Clinical Study.
    J Drugs Dermatol 2017 Apr;16(4):351-357

    BACKGROUND: Injection of hyaluronic acid (HA) volumizing fillers in the malar area is intended for rejuvenation of the mid-face. The choice of products, depth, and technique of injection depends on the desired level of volume enhancement and practitioners' preferences.

    OBJECTIVE: To describe a volumizing injection technique in the scope of a controlled, randomized, double-blind, single-center, split-face clinical study. Read More


    New Uses of AbobotulinumtoxinA in Aesthetics.
    Aesthet Surg J 2017 05;37(suppl_1):S45-S58
    Dermatologist in private practice in Miami, FL, USA.
    BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

    Granulomatous reaction to Belotero Balance: A case study.
    J Cosmet Laser Ther 2017 Oct 28;19(5):307-309. Epub 2017 Feb 28.
    b Department of Dermatology , University of California, Irvine , Irvine , CA , USA.
    Objective: The most commonly used dermal fillers are hyaluronic acids (HAs), and in general, are well tolerated with mild to moderate risk of adverse events. The most frequently reported side effects are injection site erythema and bruising. We present the first case of a patient who developed a severe granulomatous foreign body reaction to the HA filler, Belotero Balance. Read More

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