115,957 results match your criteria Der Urologe A[Journal]


Nanoparticle-nanobubble interactions: Charge inversion and re-entrant condensation of amidine latex nanoparticles driven by bulk nanobubbles.

J Colloid Interface Sci 2018 Dec 5;538:605-610. Epub 2018 Dec 5.

MESA+ Institute for Nanotechnology & Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, the Netherlands. Electronic address:

Hypothesis: The stability of colloidal suspensions can be influenced by supersaturation of the supporting electrolyte with gas. It has been proposed that this effect can be attributed to the formation of nanobubbles on the surface of the colloidal particles, in turn influencing DLVO forces. While previous interpretations have focused primarily on van der Waals interactions, probing positively charged particles can provide complementary insight into electrostatic interactions. Read More

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December 2018

Receptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Radiobiology and Experimental Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg, Hamburg-Eppendorf, Germany.

Background: The multi-kinase inhibitor sorafenib displays antitumoral effects in head and neck squamous cell carcinoma (HNSCC); however, the targeted kinases are unknown. Here we aimed to identify those kinases to determine the mechanism of sorafenib-mediated effects and establish candidate biomarkers for patient stratification.

Methods: The effects of sorafenib and MET inhibitors crizotinib and SU11274 were analyzed using a slide-based antibody array, Western blotting, proliferation, and survival assays. Read More

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December 2018

Wavelet-based reconstruction of dynamic susceptibility MR-perfusion: a new method to visualize hypervascular brain tumors.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Objectives: Parameter maps based on wavelet-transform post-processing of dynamic perfusion data offer an innovative way of visualizing blood vessels in a fully automated, user-independent way. The aims of this study were (i) a proof of concept regarding wavelet-based analysis of dynamic susceptibility contrast (DSC) MRI data and (ii) to demonstrate advantages of wavelet-based measures compared to standard cerebral blood volume (CBV) maps in patients with the initial diagnosis of glioblastoma (GBM).

Methods: Consecutive 3-T DSC MRI datasets of 46 subjects with GBM (mean age 63. Read More

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December 2018

Evaluation of new quality indicators for the TraumaRegister DGU using the systematic QUALIFY methodology.

Eur J Trauma Emerg Surg 2018 Dec 14. Epub 2018 Dec 14.

Department for Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Armed Forces Hospital Ulm, HEMS "Christoph 22", Oberer Eselsberg 40, 89081, Ulm, Germany.

Background: The TraumaRegister DGU (TR-DGU) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie, DGU) enables the participating hospitals to perform quality management. For that purpose, nine so-called audit filters have existed, since its foundation, which, inter alia, is listed in the Annual Report. The objective of this study effort is a revision of these quality indicators with the aim of developing pertinent new and reliable quality indicators for the management of severely injured patients. Read More

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December 2018
1 Read

Individual spindle detection and analysis in high-density recordings across the night and in thalamic stroke.

Sci Rep 2018 Dec 14;8(1):17885. Epub 2018 Dec 14.

Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.

Sleep spindles are thalamocortical oscillations associated with several behavioural and clinical phenomena. In clinical populations, spindle activity has been shown to be reduced in schizophrenia, as well as after thalamic stroke. Automatic spindle detection algorithms present the only feasible way to systematically examine individual spindle characteristics. Read More

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December 2018

Nucleus-specific X-ray stain for 3D virtual histology.

Sci Rep 2018 Dec 14;8(1):17855. Epub 2018 Dec 14.

Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.

Histological investigations are indispensable with regards to the identification of structural tissue details but are limited to two-dimensional images, which are often visualized in one and the same plane for comparison reasons. Nondestructive three-dimensional technologies such as X-ray micro- and nanoCT have proven to provide valuable benefits for the understanding of anatomical structures as they allow visualization of structural details in 3D and from arbitrary viewing angles. Nevertheless, low attenuation of soft tissue has hampered their application in the field of 3D virtual histology. Read More

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December 2018

CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis.

Mol Cancer Res 2018 Dec 14. Epub 2018 Dec 14.

Institute of Physiology, University of Zurich

Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation; but the functionality remains open. Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-specific Ccr2-deficient mouse model (Ccr2ecKO). Read More

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December 2018

Gender- and Age-Related Changes in Trunk Muscle Composition Using Chemical Shift Encoding-Based Water⁻Fat MRI.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Ageing, sarcopenia, and malnutrition are associated with quantitative and qualitative changes of body composition. There are several imaging modalities, including magnetic resonance imaging (MRI), for the assessment of trunk muscle tissue composition. In this study, we investigated the gender- and age-related changes in trunk muscle composition using chemical shift encoding-based water⁻fat MRI. Read More

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December 2018

[Megaimplants of the Proximal Femur: Current Concepts].

Z Orthop Unfall 2018 Dec 14;156(6):685-691. Epub 2018 Dec 14.

Klinik und Poliklinik für Orthopädie und Sportorthopädie, Klinikum rechts der Isar, Technische Universität München.

In addition to their outstanding significance in the field of tumor orthopaedics, megaprostheses are becoming increasingly important for revision arthroplasty. Despite their wide application, the reported complication and failure rates remain high. The analysis of failure mechanisms roughly allows a breakdown into mechanical and non-mechanical causes; soft-tissue failure, loosening and periprosthetic infection play outstanding roles. Read More

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December 2018
2 Reads

Examination of the complexation ability of different calixarene derivatives towards [223Ra]RaCl2 in a hospital radiopharmaceutical laboratory.

Nuklearmedizin 2018 Dec 14;57(6):242-246. Epub 2018 Dec 14.

Aim: In this contribution we investigated the potential transfer of an established method for the synthesis of Ra-labelled calixarene complexes to a hospital radiopharmaceutical environment. For this purpose, commercially available [Ra]RaCl solution in pharmaceutical grade (Xofigo) was reacted with three calixarene derivatives.

Methods: A wellestablished two-phase extraction method using a two-phase solvent system was performed for complexation of the radium ions with calixarenes under slightly basic conditions. Read More

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December 2018

FIFA World Cup 2018.

Eur Heart J 2018 Dec;39(47):4139-4142

Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Campus Innenstadt, Ziemssenstrasse 1, Munich, Germany.

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December 2018
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Sedimentary archive of Polycyclic Aromatic Hydrocarbons and perylene sources in the northern part of Taihu Lake, China.

Environ Pollut 2018 Dec 5;246:198-206. Epub 2018 Dec 5.

Institute of Applied Geosciences, Technical University of Darmstadt, Schnittspahnstrasse 9, 64287, Darmstadt, Germany; IWW Water Centre, Moritzstrasse 26, 45476, Mülheim an der Ruhr, Germany. Electronic address:

In the present work, we analyzed the concentration patterns of 20 Polycyclic Aromatic Hydrocarbons (PAHs) in 25 surface sediments and 11 sediment cores from the northern part of Taihu Lake, China. Three of the cores were dated based on Cs activity for the deposition age of the sediment. The spatial distributions of the PAH concentrations show that the inflow rivers into Zhushan Bay and Meiliang Bay were the main pathway for PAHs and sediment input to the northern part of the lake. Read More

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December 2018
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A Three-dimensional Dynamic Supramolecular "Sticky Fingers" Organic Framework.

Angew Chem Int Ed Engl 2018 Dec 14. Epub 2018 Dec 14.

SPAIN.

Engineering high recognition host-guest materials is a burgeoning area in basic and applied research. The challenge of exploring novel porous materials with advanced functionalities, prompted us to develop dynamic crystalline structures promoted by soft interactions. Herein, we demonstrate the first example of a pure molecular dynamic crystalline framework held together by means of weak "sticky fingers" van der Waals interactions. Read More

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December 2018

Ultrahigh-Sensitive Broadband Photodetectors Based on Dielectric Shielded MoTe /Graphene/SnS p-g-n Junctions.

Adv Mater 2018 Dec 14:e1805656. Epub 2018 Dec 14.

Department of Physics, Southern University of Science and Technology, Shenzhen, 518055, China.

2D atomic sheets of transition metal dichalcogenides (TMDs) have a tremendous potential for next-generation optoelectronics since they can be stacked layer-by-layer to form van der Waals (vdW) heterostructures. This allows not only bypassing difficulties in heteroepitaxy of lattice-mismatched semiconductors of desired functionalities but also providing a scheme to design new optoelectronics that can surpass the fundamental limitations on their conventional semiconductor counterparts. Herein, a novel 2D h-BN/p-MoTe /graphene/n-SnS /h-BN p-g-n junction, fabricated by a layer-by-layer dry transfer, demonstrates high-sensitivity, broadband photodetection at room temperature. Read More

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December 2018

MEG imaging of recurrent gliomas reveals functional plasticity of hemispheric language specialization.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Biomagnetic Imaging Lab, Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, California.

In patients with gliomas, changes in hemispheric specialization for language determined by magnetoencephalography (MEG) were analyzed to elucidate the impact of treatment and tumor recurrence on language networks. Demonstration of reorganization of language networks in these patients has significant implications on the prevention of postoperative functional loss and recovery. Whole-brain activity during an auditory verb generation task was estimated from MEG recordings in a group of 73 patients with recurrent gliomas. Read More

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December 2018

Probing Distinctive Electron Conduction in Multilayer Rhenium Disulfide.

Adv Mater 2018 Dec 13:e1805860. Epub 2018 Dec 13.

Department of Applied Physics, Sookmyung Women's University, Seoul, 04310, Republic of Korea.

Charge carrier transport in multilayer van der Waals (vdW) materials, which comprise multiple conducting layers, is well described using Thomas-Fermi charge screening (λ ) and interlayer resistance (R ). When both effects occur in carrier transport, a channel centroid migrates along the c-axis according to a vertical electrostatic force, causing redistribution of the conduction centroid in a multilayer system, unlike a conventional bulk material. Thus far, numerous unique properties of vdW materials are discovered, but direct evidence for distinctive charge transport behavior in 2D layered materials is not demonstrated. Read More

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December 2018

Big data analysis of ab Initio molecular integrals in the neglect of diatomic differential overlap approximation.

J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.

Max-Planck-Institut für Kohlenforschung, 45470, Mülheim an der Ruhr, Germany.

Most modern semiempirical quantum-chemical (SQC) methods are based on the neglect of diatomic differential overlap (NDDO) approximation to ab initio molecular integrals. Here, we check the validity of this approximation by computing all relevant integrals for 32 typical organic molecules using Gaussian-type orbitals and various basis sets (from valence-only minimal to all-electron triple-ζ basis sets) covering in total more than 15.6 million one-electron (1-e) and 10. Read More

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December 2018

Activating mutations in the MAP-kinase pathway define non-ossifying fibroma of bone.

J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.

Non-ossifying fibroma, which occasionally results in pathologic fracture, is considered the most common benign and self-limiting lesion of the growing skeleton. By DNA sequencing we have identified hotspot KRAS, FGFR1 and NF1 mutations in 48 of 59 patients (81.4%) with NOF, at allele frequencies ranging from 0. Read More

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December 2018

High-Performance Photoinduced Memory with Ultrafast Charge Transfer Based on MoS /SWCNTs Network Van Der Waals Heterostructure.

Small 2018 Dec 13:e1804661. Epub 2018 Dec 13.

State Key Laboratory for Chemo/Biosensing and Chemometrics, School of Physics and Technology, Wuhan University, Wuhan, 430072, China.

Photoinduced memory devices with fast program/erase operations are crucial for modern communication technology, especially for high-throughput data storage and transfer. Although some photoinduced memories based on 2D materials have already demonstrated desirable performance, the program/erase speed is still limited to hundreds of micro-seconds. A high-speed photoinduced memory based on MoS /single-walled carbon nanotubes (SWCNTs) network mixed-dimensional van der Waals heterostructure is demonstrated here. Read More

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December 2018

Evaluation of artificial heating sources for the thermoregulation of Aldabra giant tortoises (Aldabrachelys gigantea) in Zurich zoo.

Zoo Biol 2018 Nov 22;37(6):458-465. Epub 2018 Nov 22.

Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty, University of Zürich, Zurich, Switzerland.

We recorded the thermoregulatory patterns of five Aldabra giant tortoises (Aldabrachelys gigantea) (25-193 kg) during spring (ZRH spring trial), after the installation of a heating area (concrete heat pad and basking lamp) at Zurich Zoo, Switzerland. The measurements were compared to published results on the same tortoises observed prior to the installation of the heater (ZRH summer and winter trials), and on wild tortoises on Aldabra Atoll. The mean environmental temperature outside the heating area was 23. Read More

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November 2018

Hepatitis E virus blood donor NAT screening: as much as possible or as much as needed?

Transfusion 2018 Dec 13. Epub 2018 Dec 13.

Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein- Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

Background: The cost-benefit question of general screening of blood products for the hepatitis E virus (HEV) is currently being discussed. One central question is the need for individual nucleic acid amplification techniques (NAT) screening (ID-NAT) versus minipool NAT screening (MP-NAT) approaches to identify all relevant viremias in blood donors. Here, the findings of ID-NAT versus MP-NAT in pools of 96 samples were compared. Read More

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December 2018
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Do lifestyle interventions during pregnancy have the potential to reduce long-term postpartum weight retention? A systematic review and meta-analysis.

Obes Rev 2018 Dec 12. Epub 2018 Dec 12.

Else Kroener-Fresenius Center for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Reducing postpartum weight retention is a promising strategy for addressing the rising prevalence of overweight and obesity in women. This systematic review and meta-analysis explored whether lifestyle interventions during pregnancy have the potential to reduce weight retention at 4 months postpartum and beyond. A search of five electronic databases for randomized controlled trials comparing the effect of weight-related lifestyle interventions beginning in pregnancy on postpartum weight retention to standard prenatal care groups was performed. Read More

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December 2018

Exploring the binding interaction of the by-product of Maillard reaction 5-hydroxymethyl-2-furaldehyde with calf thymus DNA.

J Sci Food Agric 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road Nanchang, 330047, China.

Background: 5-Hydroxymethyl-2-furaldehyde (5-HMF), a kind of by-product of Maillard reaction, usually existed in fried and baked food, it may cause potential harm to human body. Here, the interaction between 5-HMF and calf thymus DNA (ctDNA) under physiological buffer (pH 7.4) was studied using multispectroscopic methods combined with multivariate curve resolution-alternating least-squares (MCR-ALS) chemometrics and molecular simulation techniques. Read More

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December 2018

Microcrystal Electron Diffraction (MicroED) for Small-Molecule Structure Determination.

Angew Chem Int Ed Engl 2018 Dec 12. Epub 2018 Dec 12.

Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.

The development of new methods to analyze and determine molecular structures parallels the ability to accelerate synthetic research. For many decades, single-crystal analysis by X-ray diffraction (SXRD) has been the definitive tool for structural analysis at the atomic level; the drawback, however, is that a suitable single crystal of the analyte needs to be grown. The recent innovation of the crystalline sponge (CS) method allows the microanalysis of compounds simply soaked in a readily prepared CS crystal, thus circumventing the need to screen crystallization conditions while also using only a trace amount of the sample. Read More

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December 2018

Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro-RNA signature in CABG patients.

Acta Anaesthesiol Scand 2018 Dec 11. Epub 2018 Dec 11.

Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Germany.

Background: Remote ischaemic preconditioning (RIPC) can attenuate myocardial ischaemia/reperfusion injury but its underlying mechanisms remain largely unknown. Recently, extracellular vesicles (EVs) containing microRNAs (miRNAs) were shown to mediate distant intercellular communication that may be involved in cardioprotection. We tested the hypothesis that RIPC in anaesthetized patients undergoing coronary artery bypass (CABG) surgery results in the release of EVs from the ischaemic/reperfused arm into the blood stream harbouring cardioprotective miRNAs. Read More

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December 2018

Reversible Optical Writing and Data Storage in an Anthracene-Loaded Metal-Organic Framework.

Angew Chem Int Ed Engl 2018 Dec 11. Epub 2018 Dec 11.

Katholieke Universiteit Leuven, Microbial and Molecular Systems, Celestijnenlaan 200 F, 3001 , Leuven, BELGIUM.

Metal-organic frameworks (MOFs) enable the design of host-guest systems with specific properties. In this work, we show how confinement of anthracene in a well-chosen MOF host leads to reversible yellow-to-purple photoswitching of the fluorescence emission. This behavior has not been observed before for anthracene, either in pure form or adsorbed in other porous hosts. Read More

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December 2018
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High-pressure behaviour of Prussian blue analogues: interplay of hydration, Jahn-Teller distortions and vacancies.

Dalton Trans 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford OX1 3QR, UK.

We report a high-pressure crystallographic study of four hydrated Prussian blue analogues: M[Pt(CN)6] and M[Co(CN)6]0.67 (M = Mn2+, Cu2+) in the range 0-3 GPa. Mn[Co(CN)6]0. Read More

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December 2018

Daphnia galeata responds to the exposure to an ichthyosporean gut parasite by down-regulation of immunity and lipid metabolism.

BMC Genomics 2018 Dec 14;19(1):932. Epub 2018 Dec 14.

Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Berlin, Germany.

Background: Regulatory circuits of infection in the emerging experimental model system, water flea Daphnia and their microparasites, remain largely unknown. Here we provide the first molecular insights into the response of Daphnia galeata to its highly virulent and common parasite Caullerya mesnili, an ichthyosporean that infects the gut epithelium. We generated a transcriptomic dataset using RNAseq from parasite-exposed (vs. Read More

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December 2018

[Career prospects of graduate Bachelor nursing degree programs - Results of a nationwide study in Germany].

Pflege 2018 Dec 14:1-10. Epub 2018 Dec 14.

2 Institut für Pflegewissenschaft, Medizinische Fakultät der Albert-Ludwigs-Universität, Freiburg i. B.

Career prospects of graduate Bachelor nursing degree programs - Results of a nationwide study in Germany Abstract.

Background: Graduates of Bachelor nursing degree programs are available on the labour market for a few years. Currently, there is no empirical evidence or reports on different fields of these academically prepared nurses in Germany. Read More

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December 2018

[Publications German-speaking countries in high impact journals: development and validation of a search filter].

Pflege 2018 Dec 14:1-10. Epub 2018 Dec 14.

3 Sektion für Forschung und Lehre in der Pflege, Institut für Sozialmedizin und Epidemiologie, Universitätsklinikum Schleswig-Holstein, Universität zu Lübeck.

Publications German-speaking countries in high impact journals: development and validation of a search filter Abstract.

Background: The number of publications in journals with a high impact factor is an indication of a discipline's participation in international discourse. A search filter allows reliable and reproducible searches for specific publications. Read More

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December 2018

Assessment of System Accuracy, Intermediate Measurement Precision, and Measurement Repeatability of a Blood Glucose Monitoring System Based on ISO 15197.

J Diabetes Sci Technol 2018 Dec 14:1932296818821105. Epub 2018 Dec 14.

1 Institut für Diabetes-Technologie, Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm, Ulm, Germany.

Background:: Analytical quality of blood glucose monitoring systems (BGMS) is an important aspect for many diabetes patients. Sufficiently high analytical quality is required for adequate diabetes therapy.

Methods:: In this study, system accuracy and measurement precision of a BGMS were assessed based on ISO 15197:2013. Read More

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December 2018

Pinning Transition of Bose-Einstein Condensates in Optical Ring Resonators.

Phys Rev Lett 2018 Nov;121(22):223601

Physikalisches Institut, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 14, D-72076 Tübingen, Germany.

We experimentally investigate the dynamic instability of Bose-Einstein condensates in an optical ring resonator that is asymmetrically pumped in both directions. We find that, beyond a critical resonator-pump detuning, the system becomes stable regardless of the pump strength. Phase diagrams and quenching curves are presented and described by numerical simulations. Read More

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November 2018

In situ characterization of nanoscale contaminations adsorbed in air using atomic force microscopy.

Beilstein J Nanotechnol 2018 23;9:2925-2935. Epub 2018 Nov 23.

Centro de Investigación en Óptica y Nanofísica (CIOyN), Departamento Física, Facultad de Química, Campus Espinardo, Universidad de Murcia, 30100 Murcia, Spain.

Under ambient conditions, surfaces are rapidly modified and contaminated by absorbance of molecules and a variety of nanoparticles that drastically change their chemical and physical properties. The atomic force microscope tip-sample system can be considered a model system for investigating a variety of nanoscale phenomena. In the present work we use atomic force microscopy to directly image nanoscale contamination on surfaces, and to characterize this contamination by using multidimensional spectroscopy techniques. Read More

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November 2018

Optimizing medical care for geriatric patients in Austria: defining a top five list of "Choosing Wisely" recommendations using the Delphi technique.

Eur Geriatr Med 2018 27;9(6):783-793. Epub 2018 Sep 27.

14Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

Purpose: Inappropriate use of diagnostic and therapeutic medical procedures is common and potentially harmful for older patients. The Austrian Society of Geriatrics and Gerontology defined a consensus of five recommendations to avoid overuse of medical interventions and to improve care of geriatric patients.

Methods: From an initial pool of 147 reliable recommendations, 20 were chosen by a structured selection process for inclusion in a Delphi process to define a list of five top recommendations for geriatric medicine. Read More

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September 2018

Bidirectional Cause-Effect Relationship Between Urinary Interleukin-6 and Mood, Irritation, and Mental Activity in a Breast Cancer Survivor.

Front Neurosci 2018 28;12:848. Epub 2018 Nov 28.

Clinical Department of Medical Psychology, Medical University of Innsbruck, Innsbruck, Austria.

This "integrative single-case study" investigated the bidirectional cause and effect relations between various emotional states (i.e., mood, irritation, mental activity) and urinary IL-6 levels in a 49-year-old female breast cancer survivor (woman) under conditions of "life as it is lived. Read More

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November 2018
1 Read

An 1800-year stable carbon isotope chronology based on sub-fossil wood from Lake Schwarzensee, Austria.

Palaeogeogr Palaeoclimatol Palaeoecol 2019 Jan 12;514:65-76. Epub 2018 Oct 12.

Silesian University of Technology, Institute of Physics - Centre for Science and Education, GADAM Centre of Excellence, Konarskiego 22B, 44-100 Gliwice, Poland.

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January 2019

Quantity and Reporting Quality of Kidney Research.

J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Ludwig Maximilians University München, Munich, Germany

Background: In 2004, researchers reported that the number of nephrology clinical trials was low and that the reporting quality of such trials was suboptimal. Furthermore, the number or quality of preclinical kidney-related studies has not been systematically evaluated.

Methods: We performed a systematic review of randomized clinical trials published in 1966-2017 (listed in the Cochrane Library) and preclinical studies published in 1945-2017 (listed in PubMed). Read More

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December 2018
1 Read

Evolution of a highly active and enantiospecific metalloenzyme from short peptides.

Science 2018 Dec;362(6420):1285-1288

Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland.

Primordial sequence signatures in modern proteins imply ancestral origins tracing back to simple peptides. Although short peptides seldom adopt unique folds, metal ions might have templated their assembly into higher-order structures in early evolution and imparted useful chemical reactivity. Recapitulating such a biogenetic scenario, we have combined design and laboratory evolution to transform a zinc-binding peptide into a globular enzyme capable of accelerating ester cleavage with exacting enantiospecificity and high catalytic efficiency (/ ~ 10 M s). Read More

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December 2018

Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial.

Respir Res 2018 Dec 13;19(1):251. Epub 2018 Dec 13.

Institute of Ageing and Chronic Disease, Clinical Science Centre, University Hospital Aintree, Liverpool, UK.

Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced expiratory volume in 1 s (FEV) preceding the first reported symptom and after the start of an exacerbation.

Methods: WISDOM was a multinational, randomized, double-blind, active-controlled, 52-week study in patients with severe-to-very severe COPD. Read More

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December 2018
1 Read

GLI 2012 equations define few spirometric anomalies in the general population: the PneumoLaus study.

Respir Res 2018 Dec 13;19(1):250. Epub 2018 Dec 13.

Department of Medicine, Respiratory Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.

Background: Reduced lung function predicts increased mortality, but its prevalence may vary depending on definition considered, use of bronchodilation and applied reference values. We aimed to assess lung function abnormalities in Lausanne, Switzerland, and their association with clinical history.

Methods: In a general population sample, spirometry was performed and bronchodilation applied if the ratio forced expiratory volume in 1 s (FEV1) / forced vital capacity (FVC) or the FVC was below the lower limit of normal (LLN) according to Global Lung Function Initiative 2012 references. Read More

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December 2018

Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca-Binding Proteins Calbindin-D28k and Parvalbumin.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Anatomy, Section of Medicine, University of Fribourg, Route Albert-Gockel 1, 1700 Fribourg, Switzerland.

Calretinin (CR; ) belonging to the family of EF-hand Ca-binding proteins (CaBP) is widely used as a positive marker for the identification of human malignant mesothelioma (MM) and functionally was suggested to play a critical role during carcinogenesis of this highly aggressive asbestos-associated neoplasm. Increasing evidence suggests that CR not only acts as a prototypical Ca buffer protein, i.e. Read More

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December 2018
1 Read

Hydration and Ion Pair Formation in Aqueous Lu- Solution.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Technische Universität Bergakademie Freiberg, Institut für Theoretische Physik, Leipziger Str. 23, 09596 Freiberg, Germany.

Aqueous solutions of Lu- perchlorate, triflate and chloride were measured by Raman spectroscopy. A weak, isotropic mode at 396 cm (full width at half height (fwhh) at 50 cm) was observed in perchlorate and triflate solutions. This mode was assigned to the totally symmetric stretching mode of [Lu(OH₂)₈], ν₁LuO₈. Read More

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December 2018

[ELITE study - Nutrition, lifestyle and individual information for the prevention of stroke, dementia and heart attack - Study design and cardiovascular status].

Dtsch Med Wochenschr 2018 Dec 13. Epub 2018 Dec 13.

St.-Josefs-Hospital Cloppenburg, Cloppenburg.

Background:  For the prevention of cardiovascular risk factors (RF) there are numerous recommendations of professional societies, which relate to the personal way of life of individuals (for example nutrition/diet, physical activity, stress reduction etc.). The implementation of these recommendations is so far poor. Read More

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December 2018

Polyethylene microplastics influence the transport of organic contaminants in soil.

Sci Total Environ 2018 Dec 5;657:242-247. Epub 2018 Dec 5.

University of Vienna, Department of Environmental Geosciences and Environmental Science Research Network, Althanstrasse 14, 1090 Vienna, Austria; University of Vienna, Research Platform Plastics in the Environment and Society (PLENTY), Althanstrasse 14, 1090 Vienna, Austria. Electronic address:

Plastics are now found in all natural environments including soil. The effects of microplastics in terrestrial systems, however, remain largely unexplored. Polyethylene is one of the mass-manufactured polymers found in terrestrial environments. Read More

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December 2018

Cerebrospinal fluid biomarker for Parkinson's disease: An overview.

Mol Cell Neurosci 2018 Dec 10. Epub 2018 Dec 10.

University Medical Center, Department of Neurology, Robert-Koch Strasse 40, 37075 Goettingen, Germany.

In Parkinson's disease (PD), there is a wide field of recent and ongoing search for useful biomarkers for early and differential diagnosis, disease monitoring or subtype characterization. Up to now, no biofluid biomarker has entered the daily clinical routine. Cerebrospinal fluid (CSF) is often used as a source for biomarker development in different neurological disorders because it reflects changes in central-nervous system homeostasis. Read More

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December 2018

An intermolecular forces model for lipid microbubble shells.

Langmuir 2018 Dec 13. Epub 2018 Dec 13.

Lipid-coated microbubbles are currently used clinically as ultrasound contrast agents for echocardiography and radiology, and are being developed for many new diagnostic and therapeutic applications. Accordingly, there is a growing need to engineer specific formulations by employing rational design to guide lipid selection and processing. This approach requires a quantitative relationship between lipid chemistry and interfacial properties of the microbubble shell. Read More

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December 2018

[Implications for successive employment after general nursing education programmes - a multi-perspective study].

Pflege 2018 Dec 13:1-9. Epub 2018 Dec 13.

3 Fakultät Soziale Arbeit, Gesundheit und Pflege, Hochschule Ravensburg-Weingarten.

Implications for successive employment after general nursing education programmes - a multi-perspective study Abstract.

Background: The passage of the new education law will restructure the entire nursing education system in Germany, including the broad implementation of two former pedagogical pilot programmes - a generalist nursing programme and an academic nursing programme. So far, little research has been done to determine whether these new programmes, particularly the generalist nursing programme, equip students with suitable competencies. Read More

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December 2018

PiggyBac Transposon-Based Insertional Mutagenesis in Mice.

Methods Mol Biol 2019 ;1907:171-183

Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

While sequencing and array-based studies are creating catalogues of genetic alterations in cancer, discriminating cancer drivers among the large sets of epigenetically, transcriptionally or posttranslationally dysregulated genes remains a challenge. Transposon-based genetic screening in mice has proven to be a powerful approach to address this challenge. Insertional mutagenesis directly flags biologically relevant genes and, combined with the transposon's unique molecular fingerprint, facilitates the recovery of insertion sites. Read More

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January 2019