115,757 results match your criteria Der Nervenarzt [Journal]
Aktuelle Urol 2018 Dec 6;49(6):515-518. Epub 2018 Dec 6.
Klinikum Großhadern/Innenstadt, Ludwig-Maximilians-Universität München, Urologische Klinik und Poliklinik, München.
Minimally-invasive treatment options for patients with LUTS due to benign prostatic obstruction (BPO) become more and more important because they provide equal long-term efficacy compared with the reference method TURP, while having a more favourable safety profile. There are promising results for PUL (Prostatic Urethral Lift - UroLift) with low complication rates. UroLift is clearly superior regarding the preservation of sexual functions without impairment of ejaculatory function. Read More
Aktuelle Urol 2018 Dec 6;49(6):500-508. Epub 2018 Dec 6.
Klinik und Poliklinik für Urologie und Kinderurologie der Universitätsmedizin Mainz, Mainz.
Introduction: Virtual reality (VR) is an artificially simulated environment permitting interaction. On the other hand, augmented reality (AR) is an enhanced version of reality created by the use of technology to overlay digital information on an image of something being viewed through a device. Both technologies have partially been implemented in clinical daily routine. Read More
Aktuelle Urol 2018 Dec 6;49(6):488-499. Epub 2018 Dec 6.
Urologische Universitätsklinik Mannheim, Klinik für Urologie und Kinderurologie, Mannheim.
The introduction of robotics led to a decrease in the importance of classical laparoscopy. Nevertheless laparoscopy and retroperitoneoscopy underwent significant technological improvements during the last decade, including introduction of 4k Ultra HD video technology, 3D-HD-videosystems, minaturised instruments, advanced sealing devices, instruments with 7 degrees of freedom, and ergonomic platforms Ethos Chair. The monopoly of robotic surgical devices will end in 2019, because key patents of Intuitive Surgical will expire. Read More
Aktuelle Urol 2018 Dec 6;49(6):480-481. Epub 2018 Dec 6.
Aktuelle Urol 2018 Dec 6;49(6):478-479. Epub 2018 Dec 6.
Pharmacopsychiatry 2018 Dec 6. Epub 2018 Dec 6.
Head of Department, Professor of Psychiatry and Psychotherapy, Danuvius Klinik GmbH, Pfaffenhofen an der Ilm, Technischen Universität München, Bavaria, Germany.
The combination of tiapride (TIA) and carbamazepine (CBZ) as an alternative treatment option to benzodiazepines and clomethiazole has been investigated by several investigations. We performed a systematic review and meta-analysis to further explore the efficacy of this combination in order to render more definite answers whether this combination can be recommendable in the clinical practice. We systematically searched electronic databases including PubMed (MEDLINE), EMBASE, OVID, Cochrane, Google Scholar, and Scopus for human studies. Read More
Z Orthop Unfall 2018 Dec 6. Epub 2018 Dec 6.
Zentrum für Sportorthopädie, European SportsCare Network (ESN), Wiesbaden-Nordenstadt.
Background: Reattachment of the distal Achilles tendon to the posterior calcaneus following distal Achilles tendon tears/avulsions or after excision of large posterior heel spurs is a challenging task for the orthopaedic surgeon.
Patients/material And Methods: Between 2005 and the end of 2015, 22 patients who underwent repair/reconstruction of a lesion of the distal Achilles tendon were identified from our electronic records. Calcaneal reinsertions were performed following distal Achilles tendon tears/avulsions (n = 15) or following excision of a large symptomatic posterior heel spur (n = 7). Read More
PLoS One 2018 6;13(12):e0208588. Epub 2018 Dec 6.
Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Purpose: Modern non-invasive evaluation of Coronary Artery Disease (CAD) requires non-contrast low dose Computed Tomography (CT) imaging for determination of Calcium Scoring (CACS) and contrast-enhanced imaging for evaluation of vascular stenosis. Several methods for calculation of CACS from contrast-enhanced images have been proposed before. The main principle for that is generation of virtual non-contrast images by iodine subtraction from a contrast-enhanced spectral CT dataset. Read More
ACS Nano 2018 Dec 6. Epub 2018 Dec 6.
Photo-switching behavior of individual organic molecules was imaged by annular dark-field scanning transmission electron microscopy (ADF-STEM) using a highly electron beam transparent graphene support. Photo-switching azobenzene derivatives with ligands at each ends containing single transition metal atoms (Pt) were designed (Pt-complex), and the distance between the strong ADF-STEM contrast from the two Pt atoms in each Pt-complex is used to track molecular length changes. UV irradiation was used to induce photo-switching of the Pt complex on graphene, and we show that the measured Pt-Pt distances within isolated molecules decreases from ~2. Read More
Eur Heart J 2018 Dec 5. Epub 2018 Dec 5.
Department of Cardiovascular Diseases, Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, Munich, Germany.
Aims: Bioresorbable scaffolds (BRS) provide short-term coronary artery scaffolding and drug delivery. Although prior trials showed a higher rate of device failure compared with conventional drug-eluting stents (DES), only a single trial investigated patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). We aimed to compare outcomes with BRS vs. Read More
Phys Chem Chem Phys 2018 Dec 6. Epub 2018 Dec 6.
Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea and School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, Seoul 08826, Republic of Korea.
Heterostructures constructed of graphene and colloidal nanocrystals provide a unique way to exploit the coupled physical properties of the two functional building blocks. Studying the interface structure between the two constituent materials is important to understand the formation mechanism and the resulting physical and chemical properties. Along with ab initio calculations, we elucidate that the bending rigidity and the strong van der Waals interaction of graphene to the metal surface guide the formation of a tight and conformal interface. Read More
Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.
Department of Hematology, Oncology and Tumour Immunology, Charité University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany.
Purpose Of Review: Over the last decades the time which is needed to translate a preclinical finding or idea in the clinic has reduced continuously. Especially but not only for breast cancer the number of tested drugs and targeted pathways have increased immensely. In addition, the introduction of immune-oncological treatments has further advanced the possibilities for future treatments. Read More
J Gen Virol 2018 Dec 6. Epub 2018 Dec 6.
Institute of Virology, University of Bonn, Bonn, Germany.
While it is fairly clear that herpes simplex virus (HSV) DNA replication requires at least seven virus-encoded proteins in concert with various host cell factors, the mode of this process in infected cells is still poorly understood. Using HSV-1 mutants bearing temperature-sensitive (ts) lesions in the UL9 gene, we previously found that the origin-binding protein (OBP), a product of the UL9 gene, is only needed in the first 6 hours post-infection. As this finding was just a simple support for the hypothesis of a biphasic replication mode, we became convinced through these earlier studies that the mutants tsR and tsS might represent suitable tools for more accurate investigations in vivo. Read More
J Vet Intern Med 2018 Dec 6. Epub 2018 Dec 6.
Department of Clinical Research, University of Bern, Berne, Switzerland.
Background: Genetic, epidemiologic, and clinical evidence suggests that, in horses, there are manifestations of hypersensitivity that can occur together.
Objectives: To investigate whether concurrent insect bite hypersensitivity (IBH) and severe equine asthma (EA) is associated with higher allergen-specific and total serum immunoglobulin E (IgE) concentrations than only EA or IBH.
Animals: Healthy control horses (C, n = 40), horses with IBH (IBH, n = 24), severe EA (EA, n = 18), and both conditions (IBH/EA, n = 23) were included. Read More
ChemMedChem 2018 Dec 6. Epub 2018 Dec 6.
Department of Chemistry and Biochemistry, National Center of Competence in Research NCCR TransCure, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.
By screening a focused library of kinase inhibitor analogues in a phenotypic co-culture assay for angiogenesis inhibition, we identified an aminotriazine that acts as a cytostatic nanomolar inhibitor. However, this aminotriazine was found to be completely inactive in a whole-kinome profiling assay. To decipher its mechanism of action, we used the online target prediction tool PPB2 (http://ppb2. Read More
Aging Clin Exp Res 2018 Dec 5. Epub 2018 Dec 5.
Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg, Kobergerstraße 60, 90408, Nuremberg, Germany.
Objective: Animal protein sources are considered to be of higher quality than plant protein sources in terms of stimulating muscle metabolism. Our objective was to investigate whether protein intake from animal and plant sources on a daily and per-meal basis differs between healthy older adults with normal and with low muscle mass.
Methods: In this cross-sectional study including 100 healthy, community-dwelling adults (51 women) aged 75-85 years without functional limitations dietary intake was assessed using 7-day food records. Read More
Methods Mol Biol 2019 ;1888:1-20
Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
PREDECT, a European IMI consortium, has assumed the task to generate robust 2D and 3D culture platforms. Protocols established for 2D and 3D monoculture and stromal coculture models of increasing complexity (spheroid, stirred-tank bioreactor, Matrigel- and collagen-embedded cultures) have been established between six laboratories within academia, biotech, and pharma. These models were tested using three tumor cell lines (MCF7, LNCaP, and NCI-H1437), covering three pathologies (breast, prostate, and lung), but should be readily transferable to other model systems. Read More
Clin Neuroradiol 2018 Dec 5. Epub 2018 Dec 5.
Department of Neurosurgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.
Purpose: In patients with supratentorial lesions diffusion tensor imaging fiber tracking (DTI-FT) is increasingly used to visualize subcortical fiber courses. Navigated transcranial magnetic stimulation (nTMS) was applied in this study to reveal specific cortical functions by investigating the particular language errors elicited by stimulation. To make DTI-FT more function-specific, the identified language-positive nTMS spots were used as regions of interest (ROIs). Read More
Z Gerontol Geriatr 2018 Dec 5. Epub 2018 Dec 5.
Abteilung Klinisch-Psychologische Intervention, Institut der Psychologie, Friedrich-Schiller-Universität Jena, Semmelweißstraße 12, 07743, Jena, Deutschland.
Background: In view of the demographic changes and the associated increasing need for care, the role of caregiving sons will also become more important; however, little is known about the caregiving experiences of sons.
Objective: Potential differences between caregiving sons and daughters were investigated with respect to the style of caregiving, the feeling of stress and burden and the utilization of support offers.
Material And Methods: Baseline survey data from the interventional study Tele. Read More
Radiologe 2018 Dec 5. Epub 2018 Dec 5.
Universitätsinstitut für Radiologie, Universitätsklinikum der Paracelsus Medizinischen Privatuniversität, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.
Background: Acute pelvic pain in women may be due to gynecological, gastrointestinal, and urinary tract disorders. Ectopic pregnancy (EP), pelvic inflammatory disease (PID), and ruptured ovarian cysts are the most common gynecological causes for acute pelvic pain and their diagnosis can be challenging.
Methods: Patient history, clinical examination, and blood tests as well as patient age and potential pregnancy status help to establish the correct diagnosis. Read More
Urologe A 2018 Dec;57(12):1431-1432
Berufsverband der Deutschen Urologen e. V., Sylt OT Keitum, Deutschland.
HNO 2018 Dec 5. Epub 2018 Dec 5.
Campus Lübeck, Klinik für HNO-Heilkunde, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland.
Background: Whereas sentence tests are commonly performed using an adaptive procedure, this method has not yet been transferred to the Freiburg monosyllabic speech test, the most important word test. When using different procedures, a comparison of results between sentence and word tests is not possible. Therefore, an adaptive procedure which has proven itself in sentence tests was transferred to the Freiburg monosyllabic test in noise. Read More
Phys Chem Chem Phys 2018 Dec 6. Epub 2018 Dec 6.
Max Planck Institute of Colloids and Interfaces, D-14424 Potsdam/Golm, Germany.
The monolayers of N-alkanoyl substituted threonine amphiphiles, similar to those of other N-alkanoyl-substituted amino acid amphiphiles, point to substantial differences in the main characteristics compared to usual amphiphilic monolayers. π-A measurements of the enantiomeric and racemic forms of N-alkanoyl-substituted threonine monolayers with C16 and C18 chain lengths reveal that, independent of the alkyl chain length, all compression curves are located above the corresponding decompression curves. A theoretical model developed for the kinetics of two-dimensional condensation of Langmuir monolayers can describe this behavior concluding the attachment of monomers to large aggregates. Read More
Biomed Res Int 2018 1;2018:8989252. Epub 2018 Nov 1.
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.
Background: Diabetes mellitus (DM) has been associated with increased platelet reactivity as well as increased levels of platelet RNAs in plasma. Here, we sought to evaluate whether the platelet transcriptome is altered in the presence of uncontrolled DM.
Methods: Next-generation sequencing (NGS) was performed on platelet RNA for 5 patients with uncontrolled DM (HbA1c 9. Read More
Nature 2018 Dec 5. Epub 2018 Dec 5.
Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need. Xenotransplantation of genetically modified pig hearts has been discussed as a potential alternative. Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons. Read More
Future Med Chem 2018 Dec 6. Epub 2018 Dec 6.
Department of Molecular Biochemistry, Faculty of Chemistry, University of Gdansk, ul. Wita Stwosza 63, 80-308 Gdansk, Poland.
Matriptase-2 (MT2) is a membrane-anchored proteolytic enzyme. It acts as the proteolytic key regulator in human iron homeostasis. A high expression level can lead to iron overload diseases, whereas mutations in the gene encoding MT2, TMPRSS6, may result in various forms of iron deficiency anemia. Read More
Materials (Basel) 2018 Dec 4;11(12). Epub 2018 Dec 4.
Research and Development Center for Solid State Lighting, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China.
Van der Waals epitaxy (vdWE) has drawn continuous attention, as it is unlimited by lattice-mismatch between epitaxial layers and substrates. Previous reports on the vdWE of III-nitride thin film were mainly based on two-dimensional (2D) materials by plasma pretreatment or pre-doping of other hexagonal materials. However, it is still a huge challenge for single-crystalline thin film on 2D materials without any other extra treatment or interlayer. Read More
Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.
Biotechnology Institute Thurgau (BITg) at the University of Konstanz, CH-8280 Kreuzlingen, Switzerland.
Chemokines are essential guidance cues orchestrating cell migration in health and disease. Cognate chemokine receptors sense chemokine gradients over short distances to coordinate directional cell locomotion. The chemokines CCL19 and CCL21 are essential for recruiting CCR7-expressing dendritic cells bearing pathogen-derived antigens and lymphocytes to lymph nodes, where the two cell types meet to launch an adaptive immune response against the invading pathogen. Read More
Materials (Basel) 2018 Dec 4;11(12). Epub 2018 Dec 4.
Computational and Design Center for Low-dimensional Quantum Material, and College of Science, Zhongyuan University of Technology, Zhengzhou 450007, China.
Dispersion-corrected density functional theory (DFT) calculations reveal that the layered electride of dicalcium nitride (Ca₂N) exhibits stronger interlayer binding interactions but lower interlayer friction behavior than that of traditional layered lubricants weakly bonded by van der Waals (vdW) interactions, such as graphite, -BN, and MoS₂. These results are attributed to the two-dimensional (2D) homogeneous conduction electrons distribution in the middle of the interlayer space of Ca₂N, which yields a smooth sliding barrier and hence ultralow friction behavior. The interesting results obtained in this study have not only broadened the scope of 2D solid lubricants but also enriched the physical understanding of ultralow friction mechanism for 2D systems. Read More
Psychiatr Prax 2018 Dec 3. Epub 2018 Dec 3.
Freiberufliche Peer Support Specialist, Zürich, Schweiz.
Background: Due to the stigma associated with mental disorders, many people with mental illness face the difficult choice whether to disclose their illness to others. (Non-)Disclosure is a key reaction in coping with stigma. Disclosure as well as non-disclosure have risks and benefits, depending on the environment and the individual. Read More
Fortschr Neurol Psychiatr 2018 Dec 3. Epub 2018 Dec 3.
Marien Hospital Herne, Universitätsklinikum der Ruhr- Universität Bochum, Abteilung für Neuro-Urologie.
An overactive neurogenic detrusor and an non-neurogenic overactive bladder both exhibit symptoms such as urgency and frequency, both with and without urinary incontinence, and are often accompanied by nocturia. OnabotulinumtoxinA-Detrusorinjection has become well established as a second line therapy in cases where anticholinergic medication has failed. The procedure can be performed under general or local anesthesia, in both in- and outpatient settings. Read More
Dtsch Med Wochenschr 2018 Dec 3;143(24):1789-1790. Epub 2018 Dec 3.
Institut für Diagnostische und Interventionelle Radiologie, HELIOS Klinikum Krefeld.
Dtsch Med Wochenschr 2018 Dec 3;143(24):1784-1788. Epub 2018 Dec 3.
Medizinische Klinik 1, Universitätsklinikum Frankfurt am Main.
Aims Of Antiviral Therapy: Aim of antiviral therapy on an individual patient level is a sustained virologic response, on a population level the elimination of the hepatitis C virus (HCV). The latter is an aim also defined by the WHO.
Antiviral Drugs And Drug-drug Interactions: Specific inhibitors of the RNA-dependent RNA-polymerase, the NS3/4A protease, and the NS5A protein as well as ribavirin are available for antiviral therapy of HCV. Read More
Dtsch Med Wochenschr 2018 Dec 3;143(24):1778-1782. Epub 2018 Dec 3.
Klinik für Immunologie und Rheumatologie der Medizinischen Hochschule Hannover.
Primary Sjögren's syndrome (pSS) is an autoimmune disease affecting the salivary and lachrymal glands. The patients complain of symptoms of dry eyes and dry mouth, but up to 50 % may additionally develop extraglandular manifestations such as arthritis, vasculitis, polyneuropathy, pulmonary fibrosis or interstitial nephritis. Most therapeutic studies on the glandular manifestations of pSS failed to meet their primary endpoints, possibly since many of the patients had already advanced and irreversible disease. Read More
Dtsch Med Wochenschr 2018 Dec 3;143(24):1765-1769. Epub 2018 Dec 3.
Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf, Düsseldorf.
Surgical management of patients with aortic valve stenosis is declining and Transcatheter aortic valve implantation (TAVI) is becoming the treatment of choice in many patients. The ESC guideline integrated results of randomized controlled trials in patients with intermediate surgical risk for the first time. TAVI showed good and comparable results to the standard surgical approach. Read More
Dtsch Med Wochenschr 2018 Dec 3;143(24):1755-1758. Epub 2018 Dec 3.
Klinische Arbeitsgemeinschaft AIDS Deutschland (KAAD), Sektion der Deutschen AIDS-Gesellschaft (DAIG).
Guidelines from 3 clinical societies and peer-reviewed publications have been reviewed for recent changes in the management of opportunistic infections. Trimethoprim and sulfamethoxazol administered intravenously is an option to treat cerebral toxoplasmosis if oral therapy is not feasible. CD4 T cell cut-off for starting prophylaxis with trimethoprim and sulfamethoxazole is now 200/µl. Read More
Pneumologie 2018 Dec 3. Epub 2018 Dec 3.
Universitätsklinikum Hamburg-Eppendorf, ehem. Lehrstuhl Arbeitsmedizin und Maritime Medizin; European Society for Environmental und Occupational Medicine (EOM Society).
The chronic obstructive pulmonary disease (COPD) is characterised by mainly non-reversible bronchial obstruction with airflow limitation. Typically, it exhibits a progressive course. It is one of the leading causes of morbidity and mortality worldwide. Read More
Med Probl Perform Art 2018 Dec;33(4):251-257
University of Music Franz Liszt Weimar, Platz der Demokratie 2/3, 99423 Weimar, Germany. Tel +491706264778.
Aims: Back strain is a common musculoskeletal complaint affecting musicians, which may be related to unsuitable playing positions causing fatigue and muscle tension. In this study, three saxophone-carrying systems (neck-strap, shoulder-strap, and Saxholder) were examined for their effects on spinal column kinematics.
Methods: The influence of saxophone-carrying systems was investigated in 14 physically healthy alto saxophonists using ultrasound topometry. Read More
Chemosphere 2018 Nov 27;218:818-826. Epub 2018 Nov 27.
School of Sustainable Engineering and the Built Environment, Ira A. Fulton Schools of Engineering, Arizona State University, P.O. Box 873005, Tempe, AZ 85287-3005, USA.
This research advances the knowledge of the pharmaceutical removal interactions by biochar in synthetic and real urine through the use of reference adsorbents and adsorbate probes. Earlier work has combined biochar and urine for pharmaceutical removal, however, the interactions that influence adsorption are unknown. In this study, bamboo biochar and softwood biochar were chosen as the representative materials and the model pharmaceuticals were naproxen and paracetamol. Read More
J Phys Chem A 2018 Dec 3. Epub 2018 Dec 3.
Stochastic one-dimensional chemical master equation (CME) simulation method was used to investigate the dynamics of the reaction of CH2OH with OH. A multiwell multichannel potential energy surface was constructed at the CCSD(T)/Aug-cc-pVTZ//CBS-QB3 and QCISD(T)/Aug-cc-pVTZ//CBS-QB3 levels of theory. The constructed PES consisted of three chemically activated intermediates and two van der Waals complexes. Read More
FEMS Microbiol Ecol 2018 Dec 3. Epub 2018 Dec 3.
Delft University of technology, Department of Biotechnology, Van der Maasweg 9, 2629 HZ Delft, the Netherlands.
A mechanistic understanding of microbial community establishment and product formation in open fermentative systems can aid the development of bioprocesses utilising organic waste. Kinetically, a single rate-limiting substrate is expected to result in one dominant species. Four enrichment cultures were operated to ferment either xylose or glucose in a sequencing batch reactor (SBR) or a continuous-flow stirred tank reactor (CSTR) mode. Read More
Dalton Trans 2018 Dec 3. Epub 2018 Dec 3.
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi - 221005, UP, India.
Synthesis of an entirely new series of arene ruthenium complexes [Ru(η6-C6H6)(L1)Cl]PF6, (1), [Ru(η6-C10H14)(L1)Cl]PF6 (2), [Ru(η6-C6H6)(L2)Cl]PF6 (3) and [Ru(η6-C10H14)(L2)Cl]PF6 (4) involving 5-[2-(1H-pyrazol-1-yl)quinoline]-BODIPY (L1) and 5-[6-methoxy-2-(1H-pyrazol-1-yl)quinoline]-BODIPY (L2) was described. The ligands and complexes were thoroughly characterized by various physicochemical techniques and the structures of L1, 1 and 4 were determined by X-ray single crystal analyses. Photo-/ and electrochemical property, DNA binding, cytotoxicity, cellular uptake and apoptotic studies on 1-4 were performed by various methods, while singlet oxygen-mediated cytotoxicity via photo-irradiation by visible light was supported by 1,3-diphenylisobenzofuran titration studies. Read More
Lancet Oncol 2018 Dec;19(12):e696-e708
Department of Nuclear Medicine, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Nuclear Medicine, The Institute of Cancer Research and The Royal Marsden National Health Service Foundation Trust, London, UK.
Rapid developments in imaging and treatment with radiopharmaceuticals targeting prostate cancer pose issues for the development of guidelines for their appropriate use. To tackle this problem, international experts representing medical oncologists, urologists, radiation oncologists, radiologists, and nuclear medicine specialists convened at the European Association of Nuclear Medicine Focus 1 meeting to deliver a balanced perspective on available data and clinical experience of imaging in prostate cancer, which had been supported by a systematic review of the literature and a modified Delphi process. Relevant conclusions included the following: diphosphonate bone scanning and contrast-enhanced CT are mentioned but rarely recommended for most patients in clinical guidelines; MRI (whole-body or multiparametric) and prostate cancer-targeted PET are frequently suggested, but the specific contexts in which these methods affect practice are not established; sodium fluoride-18 for PET-CT bone scanning is not widely advocated, whereas gallium-68 or fluorine-18 prostate-specific membrane antigen gain acceptance; and, palliative treatment with bone targeting radiopharmaceuticals (rhenium-186, samarium-153, or strontium-89) have largely been replaced by radium-223 on the basis of the survival benefit that was reported in prospective trials, and by other systemic therapies with proven survival benefits. Read More
Acc Chem Res 2018 Dec 3. Epub 2018 Dec 3.
DST Unit of Nanoscience (DST UNS) and Thematic Unit of Excellence (TUE), Department of Chemistry , Indian Institute of Technology Madras , Chennai 600 036 , India.
Supramolecular chemistry is a major area of chemistry that utilizes weaker non-covalent interactions between molecules, including hydrogen bonding, van der Waals, electrostatic, π···π, and C-H···π interactions. Such forces have been the basis of several molecular self-assemblies and host-guest complexes in organic, inorganic, and biological systems. Atomically precise nanoclusters (NCs) are materials of growing interest that display interesting structure-property correlations. Read More
Arthritis Rheumatol 2018 Dec 3. Epub 2018 Dec 3.
VA Nebraska-Western Iowa Health Care System, Omaha, NE, 68105.
Objective: To determine if the baseline presence of autoantibodies to peptidylarginine deiminase 4 (PAD4) predicts therapeutic response to biologic and conventional disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) who failed methotrexate (MTX) monotherapy.
Methods: Baseline serum from 282 RA patients who failed MTX monotherapy were screened for the presence of anti-PAD4 antibodies by immunoprecipitation. Clinical response to either triple DMARD (MTX, sulfasalazine, and hydroxychloroquine) or MTX-etanercept combination therapy was determined at 24- and 48-weeks post-treatment initiation. Read More
Allergy 2018 Dec 2. Epub 2018 Dec 2.
First Faculty of Medicine of Charles University and Thomayer Hospital, Department of Respiratory Medicine, Prague, Czech Republic.
Infection 2018 Dec 1. Epub 2018 Dec 1.
Department of Neurology, Klinikum der Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.
Purpose: Herpes simplex virus (HSV) encephalitis continues to be the most common form of sporadic lethal encephalitis worldwide. The wide spectrum of clinical presentations and laboratory findings often poses a diagnostic challenge for physicians which might delay administration of life-saving therapy with acyclovir. Atypical presentations of HSV encephalitis have become increasingly prevalent with better diagnostic techniques and have not been well studied. Read More
Theor Appl Genet 2018 Nov 30. Epub 2018 Nov 30.
Molecular Plant Breeding, Institute of Agricultural Sciences, ETH Zürich, Universitätsstrasse 2, 8092, Zurich, Switzerland.
Key Message: SNPs and candidate genes associated with bacterial wilt resistance in Italian ryegrass were identified by sequencing the parental plants and pooled F progeny of a segregating population. Italian ryegrass (Lolium multiflorum Lam.) is one of the most important forage grass species in temperate regions. Read More
J Comput Aided Mol Des 2018 Nov 30. Epub 2018 Nov 30.
Department of Chemistry, University of Massachusetts, Amherst, MA, 01003, USA.
In the previous paper, we reviewed the origins of energy based calculations, and the early science of FF development. The initial efforts spanning the period from roughly the early 1970s to the mid to late 1990s saw the development of methodologies and philosophies of the derivation of FFs. The use of Cartesian coordinates, derivation of the H-bond potential, different functional forms including diagonal quadratic expressions, coupled valence FFs, functional form of combination rules, and out of plane angles, were all investigated in this period. Read More
J Comput Aided Mol Des 2018 Nov 30. Epub 2018 Nov 30.
Department of Chemistry, University of Massachusetts, Amherst, MA, 01003, USA.
In this perspective, we review the theory and methodology of the derivation of force fields (FFs), and their validity, for molecular simulations, from their inception in the second half of the twentieth century to the improved representations at the end of the century. We examine the representations of the physics embodied in various force fields, their accuracy and deficiencies. The early days in the 1950s and 60s saw FFs first introduced to analyze vibrational spectra. Read More