7,770 results match your criteria Der Internist[Journal]


[Modern HIV treatment].

Internist (Berl) 2019 Feb 18. Epub 2019 Feb 18.

Deutsches Zentrum für Infektionsforschung, Köln-Bonn, Standort Köln, Köln, Deutschland.

Human immunodeficiency virus (HIV) infection has become a chronic disease with a favourable prognosis if adequate antiretroviral therapy (ART) is applied. Therefore, each patient with HIV infection should be treated irrespectively of clinical symptoms or of immunological status. A combination of three active drugs that have to be taken life-long has been standard for many years. Read More

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http://dx.doi.org/10.1007/s00108-019-0564-0DOI Listing
February 2019

[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 02 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019
1 Read

[Diagnosis and treatment of acute myeloid leukemia : The updated 2018 Onkopedia Guideline].

Internist (Berl) 2019 Feb 14. Epub 2019 Feb 14.

Medizinische Klinik und Poliklinik I, Universitätsklinikum TU Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.

In April 2018, an updated version of the previously published guidelines on acute myeloid leukemia (AML) from 2010 and 2017 was released. A revision was necessary because of two positive aspects: First, new data and insights on risk stratification and monitoring, and second, the clinical development and approval of new agents. The modified genetic risk classification allows a more precise distinction of different diagnostic groups and consequently a better matched post-remission treatment. Read More

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http://link.springer.com/10.1007/s00108-019-0562-2
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http://dx.doi.org/10.1007/s00108-019-0562-2DOI Listing
February 2019
2 Reads

[Disseminated tuberculosis during induction chemotherapy in acute myeloid leukemia].

Internist (Berl) 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Infektiologie und Spitalhygiene, Universitätsspital Basel, Petersgraben 4, 4031, Basel, Schweiz.

A patient with acute myeloid leukemia developed disseminated tuberculosis with cerebral involvement in the early phase of induction chemotherapy before allogenic stem cell transplantation. He presented with persisting fever of unknown origin, and initially misinterpreted organ lesions in CT scans. Read More

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http://dx.doi.org/10.1007/s00108-019-0565-zDOI Listing
February 2019
1 Read

Mitteilungen des BDI.

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Internist (Berl) 2019 Feb;60(2):161-166

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http://dx.doi.org/10.1007/s00108-019-0561-3DOI Listing
February 2019

Mitteilungen der DGIM.

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Internist (Berl) 2019 Feb;60(2):174-185

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http://dx.doi.org/10.1007/s00108-019-0557-zDOI Listing
February 2019

Veranstaltungsübersicht 2019.

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Internist (Berl) 2019 Feb;60(2):167-173

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http://dx.doi.org/10.1007/s00108-019-0560-4DOI Listing
February 2019

[Metabolic disorders].

Internist (Berl) 2019 Feb;60(2):113-114

Institut für Biomedizin des Alterns (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg, Kobergerstr. 60, 90408, Nürnberg, Deutschland.

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http://dx.doi.org/10.1007/s00108-019-0554-2DOI Listing
February 2019

[Two case reports on resistant hypertension].

Internist (Berl) 2019 Feb 1. Epub 2019 Feb 1.

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Primary aldosteronism (PA) is a frequent cause of resistant hypertension. The clinical presentation is heterogeneous, but a suppressed or low normal renin (especially with ACE inhibitors or sartans) should raise suspicion for primary aldosteronism, even when aldosterone levels are in the normal range. Diagnosis of unilateral hormone production from an adrenal adenoma (Conn syndrome), which is curable by surgery, requires adrenal vein sampling, which should be performed in experienced centers. Read More

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http://dx.doi.org/10.1007/s00108-019-0563-1DOI Listing
February 2019
1 Read

[Cardiomyopathy in a 22-year-old man with a long history of methamphetamine abuse].

Internist (Berl) 2019 Feb 1. Epub 2019 Feb 1.

Klinik für Kardiologie, Angiologie und Pneumologie, Innere Medizin III, Medizinische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland.

This article presents the case of a 22-year-old male patient with cardiomyopathy associated with a long history of methamphetamine abuse. Echocardiography revealed a dilated cardiomyopathy with highly reduced systolic pump function and severe mitral valve regurgitation. Inotropic treatment and MitraClip® (Abbott Vascular, Santa Clara, CA, USA) implantation resulted in enhancement of hemodynamics. Read More

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http://link.springer.com/10.1007/s00108-019-0559-x
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http://dx.doi.org/10.1007/s00108-019-0559-xDOI Listing
February 2019
2 Reads

[Interventional angiology : Endovascular treatment of chronic and acute limb ischemia].

Internist (Berl) 2019 Feb;60(2):149-160

Klinik und Poliklinik für Angiologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig (AöR), Liebigstr. 20, Haus 4, 04103, Leipzig, Deutschland.

The development of new technologies and techniques has significantly advanced the field of endovascular peripheral interventions for chronic and acute limb ischemia over the last 20 years. Nowadays, the majority of patients with symptomatic peripheral arterial occlusive disease can be treated percutaneously using an endovascular first approach as a minimally invasive alternative to classical bypass surgery. Balloon angioplasty and stent implantation are the mainstays of endovascular interventions. Read More

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http://dx.doi.org/10.1007/s00108-018-0549-4DOI Listing
February 2019
2 Reads

[Cannabis and cannabinoids-easier access, hype and disappointment : What has been confirmed in therapy?]

Internist (Berl) 2019 Jan 24. Epub 2019 Jan 24.

Zentrum für Seltene Erkrankungen (ZSEB), Universitätsklinikum Bonn, 53127, Bonn, Deutschland.

Background: Cannabis products are being increasingly liberalized all over the world and there is a huge interest in cannabis-based medicine.

Objectives: Presentation of current studies on the efficacy of different cannabis-based medicine for the treatment of various diseases CURRENT DATA: In German pharmaceutical legislation, nabiximols is approved for the treatment of moderate to severe therapy-resistant spasticity in multiple sclerosis and nabilone is approved for the treatment of therapy-resistant chemotherapy-associated nausea and vomiting. In case of therapy failure cannabinoids, as part of an individual therapeutic attempt, may be considered for the treatment of chronic pain (neuropathic pain, cancer pain, non-neuropathic noncancer pain), cachexia in human immunodeficiency virus as well as for Dravet and Lennox-Gastaut syndrome. Read More

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http://dx.doi.org/10.1007/s00108-019-0556-0DOI Listing
January 2019
2 Reads

[Diagnosis and therapy of sarcopenia-an update].

Internist (Berl) 2019 Feb;60(2):141-148

Netzwerk AlternsfoRschung (NAR) der Universität Heidelberg, Heidelberg, Deutschland.

Since 2016 sarcopenia, the age-associated loss of muscle mass, strength and function, has the ICD-10-GM code M62.50 (International Statistical Classification of Diseases and Related Health Problems, 10th Revision, German Modification). The diagnosis of sarcopenia requires the combined presence of low muscle strength and low muscle mass. Read More

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http://dx.doi.org/10.1007/s00108-018-0551-xDOI Listing
February 2019
1 Read

Mitteilungen des BDI.

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Internist (Berl) 2019 Jan;60(1):59-63

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http://dx.doi.org/10.1007/s00108-018-0533-zDOI Listing
January 2019
1 Read

Mitteilungen der DGIM.

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Internist (Berl) 2019 Jan;60(1):71-85

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http://dx.doi.org/10.1007/s00108-018-0537-8DOI Listing
January 2019
1 Read

Veranstaltungsübersicht 2019.

Authors:

Internist (Berl) 2019 Jan;60(1):64-70

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http://dx.doi.org/10.1007/s00108-018-0534-yDOI Listing
January 2019
1 Read

[Multiple myeloma].

Authors:
M Hallek H Haller

Internist (Berl) 2019 Jan;60(1):1-2

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

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http://dx.doi.org/10.1007/s00108-018-0553-8DOI Listing
January 2019
2 Reads

[European guidelines for the management of arterial hypertension 2018-what has changed?]

Internist (Berl) 2019 Feb;60(2):202-208

Medizinische Klinik 4 - Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen (FAU), Ulmenweg 18, 91054, Erlangen, Deutschland.

Background: In November 2017, the latest American guidelines for the management of arterial hypertension were published. With these guidelines lowering the threshold for hypertension to 130/80 mm Hg, the latest European guidelines were expected with excitement.

Objectives: This article gives an overview on the European Society of Cardiology (ESC) and European Society of Hypertension (ESH) 2018 guidelines for the management of arterial hypertension, thereby identifying the most relevant changes in comparison to previous guidelines. Read More

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http://dx.doi.org/10.1007/s00108-018-0552-9DOI Listing
February 2019
1 Read

[New aspects of nonalcoholic steatohepatitis].

Authors:
N Stefan

Internist (Berl) 2019 Feb;60(2):128-132

Abteilung für Innere Medizin IV, Bereiche Endokrinologie, Diabetologie, Angiologie, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.

During the past 10 years nonalcoholic fatty liver disease (NAFLD) has moved more and more into the focus of attention of clinical research. The term NAFLD comprises the simple nonalcoholic steatosis or fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). As the incidence of NAFLD has dramatically increased, it is expected that during the coming years NASH in particular will become the main reason for liver transplantation in industrialized countries. Read More

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http://dx.doi.org/10.1007/s00108-018-0550-yDOI Listing
February 2019
1 Read

[Importance of sleep and circadian rhythm for energy metabolism].

Internist (Berl) 2019 Feb;60(2):122-127

Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

The circadian clock is a complex and highly specialized network of the human organism and is key for metabolic health. Circadian rhythms are modulated by behavioral patterns, physical activity, food intake as well as sleep loss and sleep disorders. Furthermore, an altered expression of clock genes (e. Read More

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http://dx.doi.org/10.1007/s00108-018-0543-xDOI Listing
February 2019
2 Reads

[Endoscopic and surgical treatment of chronic pancreatitis].

Internist (Berl) 2019 Jan 11. Epub 2019 Jan 11.

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 München, Deutschland.

With an increasing number of hospital admissions, an average of 16-to 20 days in hospital per year, 34% of patients constantly taking pain medication, 57% in need of enzyme supplementation, and 29% with diabetes mellitus, chronic pancreatitis is a debilitating disease of high socio-economic relevance. In total, 33% of all patients suffering from chronic pancreatitis can no longer practice their original profession. The number of unemployed chronic pancreatitis patients due to prolonged stays in hospital or continued alcohol abuse is known to be as high as 40%. Read More

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http://dx.doi.org/10.1007/s00108-018-0546-7DOI Listing
January 2019
3 Reads

[Diagnosis and treatment of kidney involvement in plasma cell diseases : Renal involvement in multiple myeloma and monoclonal gammopathies].

Internist (Berl) 2019 Jan;60(1):10-22

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Background: Kidney involvement is a common complication in patients with plasma cell diseases.

Objective: This article outlines the spectrum of renal involvement in plasma cell dyscrasia and describes diagnostic and therapeutic measures to guide clinical management.

Material And Methods: Evaluation and discussion of the current literature as well as existing guidelines and recommendations of professional societies. Read More

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http://dx.doi.org/10.1007/s00108-018-0538-7DOI Listing
January 2019
2 Reads

[Recognize rare diseases on the skin].

Internist (Berl) 2019 Feb;60(2):193-201

Klinik für Dermatologie und Allergologie, Universitätsklinikum Marburg (UKGM), Baldingerstr. 1, 35043, Marburg, Deutschland.

The correct interpretation of skin manifestations can facilitate the diagnosis of many rare systemic diseases. Such manifestations can be due to autoimmune diseases (e.g. Read More

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http://dx.doi.org/10.1007/s00108-018-0548-5DOI Listing
February 2019
3 Reads

[Patients with cystic fibrosis become adults : Treatment hopes and disappointments].

Internist (Berl) 2019 Jan;60(1):98-108

Sektion Cystische Fibrose, Klinik für Pädiatrie mit Schwerpunkt Pneumologie, Immunologie und Intensivmedizin, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland.

Mucoviscidosis or cystic fibrosis (CF) is one of the most frequent monogenetic diseases in middle Europe. It is inherited in an autosomal recessive manner. A defect in the cystic fibrosis transmembrane conductance regulator (CFTR) channel reduces chloride ion transport to the cell membrane, which leads to malfunctions in all exocrine glands. Read More

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http://link.springer.com/10.1007/s00108-018-0536-9
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http://dx.doi.org/10.1007/s00108-018-0536-9DOI Listing
January 2019
9 Reads

[Pancreatic neuroendocrine tumors : Current treatment concepts].

Authors:
A Rinke T M Gress

Internist (Berl) 2019 Jan 8. Epub 2019 Jan 8.

Klinik für Gastroenterologie, Endokrinologie, Stoffwechsel und klinische Infektiologie, UKGM - Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg, Baldingerstraße, 35043, Marburg, Deutschland.

The number of cases diagnosed as pancreatic neuroendocrine neoplasia (pNEN) is steadily increasing. The 2017 World Health Organization classification defines a new subgroup of morphologically well differentiated tumors with an elevated proliferation rate (Ki-67 over 20%) as neuroendocrine tumor (NET) G3. Due to the heterogeneity of pNEN regarding etiology (sporadic versus hereditary), symptoms (hormone syndrome versus non-functional tumor), and prognosis (ranging from benign behavior to highly malignant), multidisciplinary management by experienced physicians is required. Read More

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http://dx.doi.org/10.1007/s00108-018-0545-8DOI Listing
January 2019
1 Read

[Patient-centered care of multimorbid patients].

Internist (Berl) 2019 Jan 8. Epub 2019 Jan 8.

, Lippetal, Deutschland.

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http://dx.doi.org/10.1007/s00108-018-0539-6DOI Listing
January 2019
1 Read

[Cystic lesions of the pancreas : Differential diagnostics and treatment].

Authors:
J Rosendahl P Michl

Internist (Berl) 2019 Jan 8. Epub 2019 Jan 8.

Klinik für Innere Medizin I, Universitätsklinikum Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.

Cystic space-occupying lesions of the pancreas represent incidental findings in most cases. As there is a potential risk of malignant transformation further evaluation of the lesions as well as a follow-up of these patients is usually recommended. Before this work-up is initiated the clinical situation of the patient as a whole and comorbidities, age and personal preferences have to be taken into account. Read More

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http://dx.doi.org/10.1007/s00108-018-0547-6DOI Listing
January 2019
1 Read

[Glucose metabolism in older patients].

Internist (Berl) 2019 Feb;60(2):133-140

Lehrstuhl für Altersmedizin, Klinik für Innere Medizin und Geriatrie am Franziskushospital Aachen, Uniklinik RWTH Aachen, Morillenhang 27, 52074, Aachen, Deutschland.

Current guidelines for specialized treatment of diabetes mellitus in the elderly (>65 years old) are primarily based on epidemiologic studies and geriatric assessment of functional health. Yet, age-dependent alterations of glucose metabolism and homeostasis are highly relevant to the pathophysiology of diabetes in the elderly. In this review, we focus on age-related alterations in metabolic pathways and their relevance for the specialized diabetic care in the elderly. Read More

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http://dx.doi.org/10.1007/s00108-018-0542-yDOI Listing
February 2019
1 Read

[Physiology and clinical importance of white, beige and brown adipose tissue].

Internist (Berl) 2019 Feb;60(2):115-121

Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

The metabolic functions of different kinds of adipose tissue are of growing scientific and clinical interest. White adipose tissue is not only an energy store but as a highly active endocrine organ it also plays an essential role in the development of diabetes mellitus, dyslipidemia, arterial hypertension and cardiovascular diseases. Brown adipose tissue, on the other hand, can convert chemical energy into heat and could therefore have an opposing, protective effect. Read More

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http://dx.doi.org/10.1007/s00108-018-0540-0DOI Listing
February 2019
1 Read

[Neuropathic pain syndromes and channelopathies].

Internist (Berl) 2019 Jan;60(1):90-97

Institut für Humangenetik, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

Background: The causes for neuropathic pain are manifold and remain unexplained in the majority of cases. In recent years a growing number of pain syndromes have been attributed to mutations in genes encoding voltage-gated sodium channels. Hence, this group of rare diseases should be considered in the differential diagnostics of neuropathic pain. Read More

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http://dx.doi.org/10.1007/s00108-018-0535-xDOI Listing
January 2019
2 Reads

[Nutrition in type 2 diabetes mellitus].

Authors:
S Brede H Lehnert

Internist (Berl) 2019 Jan;60(1):49-58

Medizinische Klinik 1, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

The increasing incidence of metabolic diseases, such as type 2 diabetes mellitus, poses a major problem for the healthcare system. Healthy food habits represent an important therapeutic measure to prevent health sequelae, such as cardiovascular diseases. According to recent data these are less due to individual dietary components and more to the composition of nutrition. Read More

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http://link.springer.com/10.1007/s00108-018-0531-1
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http://dx.doi.org/10.1007/s00108-018-0531-1DOI Listing
January 2019
8 Reads

[Management of osseous complications in multiple myeloma].

Internist (Berl) 2019 Jan;60(1):42-48

Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Skeletal lesions caused by multiple myeloma often lead to pain, pathological fractures, spinal instability, and compression of the spinal cord and nerve roots. The choice of therapy options is made by an interdisciplinary basis with oncologists and radiotherapists on the basis of comorbidities, prognosis, localization, and number of lesions. Surgical management has a supportive role in pain relief, the prevention and treatment of pathological fractures, and the decompression of the spinal cord and nerve roots. Read More

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http://dx.doi.org/10.1007/s00108-018-0530-2DOI Listing
January 2019
2 Reads

[First-line treatment of multiple myeloma].

Internist (Berl) 2019 Jan;60(1):23-33

Medizinische Klinik V, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland.

Within the last two decades the therapeutic options for newly diagnosed multiple myeloma have changed dramatically. The implementation of high-dose chemotherapy with melphalan and subsequent autologous blood stem cell transplantation initially led to prolonged survival in younger, fit patients. Furthermore, recent data suggest that patients with high-risk disease seem to benefit most from tandem transplantation approaches. Read More

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http://dx.doi.org/10.1007/s00108-018-0527-xDOI Listing
January 2019
1 Read

[Erratum to: Thyroid gland and the heart].

Internist (Berl) 2019 Feb;60(2):216

Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie und Diabetologie, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97070, Würzburg, Deutschland.

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http://dx.doi.org/10.1007/s00108-018-0532-0DOI Listing
February 2019
1 Read

[Pathogenesis of multiple myeloma].

Authors:
L Rasche N Weinhold

Internist (Berl) 2019 Jan;60(1):3-9

Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Multiple myeloma (MM) is a hematologic malignancy characterized by monoclonal plasma cells infiltrating the bone marrow thereby causing anemia and lytic bone lesions. Despite significant improvement in overall survival, most MM patients inevitably, yet unpredictably, develop refractory disease and MM remains largely incurable.

Objective: This article describes the stages of progression and presents current insights into the pathogenesis of MM. Read More

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http://dx.doi.org/10.1007/s00108-018-0529-8DOI Listing
January 2019
2 Reads

[Diagnostic and therapeutic considerations on recurrence of multiple myeloma : A current overview].

Internist (Berl) 2019 Jan;60(1):34-41

Medizinische Klinik 2, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97074, Würzburg, Deutschland.

The treatment of multiple myeloma remains in a state of profound change. Over the past decades both disease-free survival and overall survival have been significantly prolonged by the approval of new drugs; however, despite high response rates and achievement of deep responses to primary treatment, recurrence of the disease is still expected in nearly all patients treated. Fortunately, good treatment options for myeloma patients in relapse are also currently available and the possible combinations of approved substances are numerous. Read More

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http://link.springer.com/10.1007/s00108-018-0528-9
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http://dx.doi.org/10.1007/s00108-018-0528-9DOI Listing
January 2019
14 Reads

[Lab on a Chip].

Authors:
Klaus S Drese

Internist (Berl) 2018 Nov 30. Epub 2018 Nov 30.

ISAT - Institut für Sensor- und Aktortechnik, Hochschule für angewandte Wissenschaften Coburg, Am Hofbräuhaus 1b, 96450, Coburg, Deutschland.

Background: Miniaturization has not only driven microelectronics and generated new unforeseen options but has also dramatically changed sensors and analytics.

Developments: The Lab on a Chip (LOC) technology enables laboratory processes to run fully automated in canals in the micrometre range. The biggest challenge for LOC is to keep production costs low despite miniaturization and application-specific design. Read More

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http://dx.doi.org/10.1007/s00108-018-0526-yDOI Listing
November 2018
1 Read

[What is verified in treatment?]

Authors:
H Haller

Internist (Berl) 2018 12;59(12):1229

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

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http://dx.doi.org/10.1007/s00108-018-0518-yDOI Listing
December 2018
1 Read

[Smartphone-the stethoscope of the twenty-first century].

Authors:
F Bartmann

Internist (Berl) 2018 Nov 29. Epub 2018 Nov 29.

, Liliencronweg 10, 24939, Flensburg, Deutschland.

The introduction of the stethoscope into medical diagnostics more than 200 years ago revolutionized medicine and the distribution of roles in the physician-patient relationship. For the first time the physician was in the position to perceive body and life phenomena in the patient, which remained hidden even to the patient. That was the beginning of a dependency relationship of the patient in the recognition and assessment of symptom-associated normal deviations, which is still continuing today. Read More

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http://link.springer.com/10.1007/s00108-018-0525-z
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http://dx.doi.org/10.1007/s00108-018-0525-zDOI Listing
November 2018
2 Reads

[Development and validation of a hospital frailty risk score for older people].

Internist (Berl) 2019 Jan;60(1):109-112

, Lippetal, Deutschland.

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http://dx.doi.org/10.1007/s00108-018-0524-0DOI Listing
January 2019
1 Read

[Diagnosis and treatment of aortic valve stenosis].

Internist (Berl) 2018 Dec;59(12):1279-1290

Herzzentrum - Kardiologie und Pneumologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.

Aortic valve stenosis (AS) is the most frequently observed valvular heart disease. Once it is symptomatic the mortality rapidly increases. The diagnostic gold standard is transthoracic echocardiography. Read More

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http://link.springer.com/10.1007/s00108-018-0519-x
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http://dx.doi.org/10.1007/s00108-018-0519-xDOI Listing
December 2018
10 Reads

[Speak up for people with rare diseases: ACHSE : ACHSE, Rare Diseases Germany, and its network].

Authors:
C Mundlos

Internist (Berl) 2018 Dec;59(12):1327-1334

ACHSE e. V., c/o DRK Kliniken Berlin Mitte, Drontheimer Str. 39, 13359, Berlin, Deutschland.

Approximately 4 million children and adults in Germany suffer from a chronic rare disease. In Europe a disease is considered "rare" when it afflicts no more than 5 from 10,000 inhabitants. In some rare diseases only a handful of people are affected in Germany but in others there are thousands. Read More

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http://dx.doi.org/10.1007/s00108-018-0517-zDOI Listing
December 2018
1 Read

[What is established in cell therapies? : Possibilities and limits in immuno-oncology].

Authors:
A Quaiser U Köhl

Internist (Berl) 2018 Dec;59(12):1230-1238

Fraunhofer-Institut für Zelltherapie und Immunologie, Perlickstr. 1, 04103, Leipzig, Deutschland.

Cell and gene therapy as part of immuno-oncology has reached an important milestone in medicine. After decades of experience stem cell transplantation is well established with worldwide >1 million transplantations to date. Due to the improved success of the last years using chimeric antigen receptor (CAR) T cells for CD19 positive leukemia and lymphomas, the interest in cellular therapies is continuously increasing. Read More

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http://link.springer.com/10.1007/s00108-018-0516-0
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http://dx.doi.org/10.1007/s00108-018-0516-0DOI Listing
December 2018
16 Reads

[Erratum to: Hypothyroidism-when and how to treat?]

Internist (Berl) 2019 Jan;60(1):108

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität, München, Deutschland.

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http://dx.doi.org/10.1007/s00108-018-0520-4DOI Listing
January 2019
1 Read

[Transition medicine].

Internist (Berl) 2018 Nov;59(11):1125-1127

Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover (MHH), Hannover, Deutschland.

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http://dx.doi.org/10.1007/s00108-018-0507-1DOI Listing
November 2018
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[Porphyrias-what is verified?]

Internist (Berl) 2018 Dec;59(12):1239-1248

MVZ Labor PD Dr. Volkmann und Kollegen GbR, 76133, Karlsruhe, Deutschland.

Porphyrias are caused by enzyme defects of heme biosynthesis. According to their clinical presentation and to each affected pathway, they are categorized into acute and non-acute as well as hepatic and erythropoietic porphyrias. Acute hepatic porphyrias, e. Read More

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http://link.springer.com/10.1007/s00108-018-0509-z
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http://dx.doi.org/10.1007/s00108-018-0509-zDOI Listing
December 2018
19 Reads

[What is verified for travel vaccinations?]

Authors:
Tomas Jelinek

Internist (Berl) 2018 Dec;59(12):1255-1267

BCRT - Berliner Centrum für Reise- und Tropenmedizin, Friedrichstr. 134, 10117, Berlin, Deutschland.

Vaccinations are among the most effective preventive measures modern medicine has to offer. They lead both to individual protection in those vaccinated and in many cases to the protection of others against transmission of the infection; however, the acceptance of vaccinations in Germany has declined rather than increased in recent years. Paradoxically, this is very much due to the success of the vaccinations: due to successful immunization campaigns, numerous diseases have become so rare that they have disappeared from the consciousness of the population. Read More

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http://link.springer.com/10.1007/s00108-018-0511-5
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http://dx.doi.org/10.1007/s00108-018-0511-5DOI Listing
December 2018
6 Reads