115,957 results match your criteria Der Internist[Journal]


Nanoparticle-nanobubble interactions: Charge inversion and re-entrant condensation of amidine latex nanoparticles driven by bulk nanobubbles.

J Colloid Interface Sci 2018 Dec 5;538:605-610. Epub 2018 Dec 5.

MESA+ Institute for Nanotechnology & Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, the Netherlands. Electronic address:

Hypothesis: The stability of colloidal suspensions can be influenced by supersaturation of the supporting electrolyte with gas. It has been proposed that this effect can be attributed to the formation of nanobubbles on the surface of the colloidal particles, in turn influencing DLVO forces. While previous interpretations have focused primarily on van der Waals interactions, probing positively charged particles can provide complementary insight into electrostatic interactions. Read More

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December 2018

Receptor tyrosine kinase MET as potential target of multi-kinase inhibitor and radiosensitizer sorafenib in HNSCC.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Laboratory of Radiobiology and Experimental Radiation Oncology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg, Hamburg-Eppendorf, Germany.

Background: The multi-kinase inhibitor sorafenib displays antitumoral effects in head and neck squamous cell carcinoma (HNSCC); however, the targeted kinases are unknown. Here we aimed to identify those kinases to determine the mechanism of sorafenib-mediated effects and establish candidate biomarkers for patient stratification.

Methods: The effects of sorafenib and MET inhibitors crizotinib and SU11274 were analyzed using a slide-based antibody array, Western blotting, proliferation, and survival assays. Read More

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December 2018

Wavelet-based reconstruction of dynamic susceptibility MR-perfusion: a new method to visualize hypervascular brain tumors.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Objectives: Parameter maps based on wavelet-transform post-processing of dynamic perfusion data offer an innovative way of visualizing blood vessels in a fully automated, user-independent way. The aims of this study were (i) a proof of concept regarding wavelet-based analysis of dynamic susceptibility contrast (DSC) MRI data and (ii) to demonstrate advantages of wavelet-based measures compared to standard cerebral blood volume (CBV) maps in patients with the initial diagnosis of glioblastoma (GBM).

Methods: Consecutive 3-T DSC MRI datasets of 46 subjects with GBM (mean age 63. Read More

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December 2018

Evaluation of new quality indicators for the TraumaRegister DGU using the systematic QUALIFY methodology.

Eur J Trauma Emerg Surg 2018 Dec 14. Epub 2018 Dec 14.

Department for Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Armed Forces Hospital Ulm, HEMS "Christoph 22", Oberer Eselsberg 40, 89081, Ulm, Germany.

Background: The TraumaRegister DGU (TR-DGU) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie, DGU) enables the participating hospitals to perform quality management. For that purpose, nine so-called audit filters have existed, since its foundation, which, inter alia, is listed in the Annual Report. The objective of this study effort is a revision of these quality indicators with the aim of developing pertinent new and reliable quality indicators for the management of severely injured patients. Read More

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December 2018

Individual spindle detection and analysis in high-density recordings across the night and in thalamic stroke.

Sci Rep 2018 Dec 14;8(1):17885. Epub 2018 Dec 14.

Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.

Sleep spindles are thalamocortical oscillations associated with several behavioural and clinical phenomena. In clinical populations, spindle activity has been shown to be reduced in schizophrenia, as well as after thalamic stroke. Automatic spindle detection algorithms present the only feasible way to systematically examine individual spindle characteristics. Read More

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December 2018

Nucleus-specific X-ray stain for 3D virtual histology.

Sci Rep 2018 Dec 14;8(1):17855. Epub 2018 Dec 14.

Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.

Histological investigations are indispensable with regards to the identification of structural tissue details but are limited to two-dimensional images, which are often visualized in one and the same plane for comparison reasons. Nondestructive three-dimensional technologies such as X-ray micro- and nanoCT have proven to provide valuable benefits for the understanding of anatomical structures as they allow visualization of structural details in 3D and from arbitrary viewing angles. Nevertheless, low attenuation of soft tissue has hampered their application in the field of 3D virtual histology. Read More

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December 2018

CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis.

Mol Cancer Res 2018 Dec 14. Epub 2018 Dec 14.

Institute of Physiology, University of Zurich

Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation; but the functionality remains open. Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-specific Ccr2-deficient mouse model (Ccr2ecKO). Read More

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December 2018

Gender- and Age-Related Changes in Trunk Muscle Composition Using Chemical Shift Encoding-Based Water⁻Fat MRI.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Ageing, sarcopenia, and malnutrition are associated with quantitative and qualitative changes of body composition. There are several imaging modalities, including magnetic resonance imaging (MRI), for the assessment of trunk muscle tissue composition. In this study, we investigated the gender- and age-related changes in trunk muscle composition using chemical shift encoding-based water⁻fat MRI. Read More

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December 2018

Randnotizen als Lebensspuren?.

Authors:
Ulrike Enke

Medizinhist J 2017 ;52(1):41-55

Are marginal notes marginal? Backed by a book from the private library of Emil von Behring the paper reflects whether annotations are peripheral sources or whether they can give some hints concerning biographical details. Behring's traces of reading are exposed and discussed by using the example of Otto Rot's Arzneimittel der heutigen Medicin (1877). The marginal notes demonstrate Behring's intensive work on hypnotics, sedativs, and analgetics which were possibly used for the therapy of others or himself. Read More

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January 2017

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Krankenpfl Soins Infirm 2016 ;109(10):26-27

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January 2016

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Krankenpfl Soins Infirm 2016 ;109(10):14-15

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January 2016

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Krankenpfl Soins Infirm 2016 ;109(10):12-13

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January 2016

Im Reich der unbegrenzten Moglichkeiten.

Krankenpfl Soins Infirm 2016 ;109(10):8-11

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January 2016

Wie kommt man von der Theorie in die Praxis?.

Krankenpfl Soins Infirm 2016 Sep;109(9):8-11

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September 2016

Auf der Lernplattform Lernrezepte kreieren.

Krankenpfl Soins Infirm 2016 ;109(12):24-25

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January 2016

Der digitale Schulunterricht.

Kinderkrankenschwester 2016 Sep;35(9):324

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September 2016

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Krankenpfl Soins Infirm 2017 Feb;110(1):12-13

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February 2017

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Authors:

Krankenpfl Soins Infirm 2017 Feb;110(1)

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February 2017

Transition in der Behindertenhilfe.

Kinderkrankenschwester 2016 Aug;33(10):394-398

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Der schwierige Weg der Transition.

Kinderkrankenschwester 2016 Aug;33(10):376

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[Megaimplants of the Proximal Femur: Current Concepts].

Z Orthop Unfall 2018 Dec 14;156(6):685-691. Epub 2018 Dec 14.

Klinik und Poliklinik für Orthopädie und Sportorthopädie, Klinikum rechts der Isar, Technische Universität München.

In addition to their outstanding significance in the field of tumor orthopaedics, megaprostheses are becoming increasingly important for revision arthroplasty. Despite their wide application, the reported complication and failure rates remain high. The analysis of failure mechanisms roughly allows a breakdown into mechanical and non-mechanical causes; soft-tissue failure, loosening and periprosthetic infection play outstanding roles. Read More

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December 2018
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Examination of the complexation ability of different calixarene derivatives towards [223Ra]RaCl2 in a hospital radiopharmaceutical laboratory.

Nuklearmedizin 2018 Dec 14;57(6):242-246. Epub 2018 Dec 14.

Aim: In this contribution we investigated the potential transfer of an established method for the synthesis of Ra-labelled calixarene complexes to a hospital radiopharmaceutical environment. For this purpose, commercially available [Ra]RaCl solution in pharmaceutical grade (Xofigo) was reacted with three calixarene derivatives.

Methods: A wellestablished two-phase extraction method using a two-phase solvent system was performed for complexation of the radium ions with calixarenes under slightly basic conditions. Read More

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December 2018

FIFA World Cup 2018.

Eur Heart J 2018 Dec;39(47):4139-4142

Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, Campus Innenstadt, Ziemssenstrasse 1, Munich, Germany.

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December 2018

Sedimentary archive of Polycyclic Aromatic Hydrocarbons and perylene sources in the northern part of Taihu Lake, China.

Environ Pollut 2018 Dec 5;246:198-206. Epub 2018 Dec 5.

Institute of Applied Geosciences, Technical University of Darmstadt, Schnittspahnstrasse 9, 64287, Darmstadt, Germany; IWW Water Centre, Moritzstrasse 26, 45476, Mülheim an der Ruhr, Germany. Electronic address:

In the present work, we analyzed the concentration patterns of 20 Polycyclic Aromatic Hydrocarbons (PAHs) in 25 surface sediments and 11 sediment cores from the northern part of Taihu Lake, China. Three of the cores were dated based on Cs activity for the deposition age of the sediment. The spatial distributions of the PAH concentrations show that the inflow rivers into Zhushan Bay and Meiliang Bay were the main pathway for PAHs and sediment input to the northern part of the lake. Read More

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December 2018

A Three-dimensional Dynamic Supramolecular "Sticky Fingers" Organic Framework.

Angew Chem Int Ed Engl 2018 Dec 14. Epub 2018 Dec 14.

SPAIN.

Engineering high recognition host-guest materials is a burgeoning area in basic and applied research. The challenge of exploring novel porous materials with advanced functionalities, prompted us to develop dynamic crystalline structures promoted by soft interactions. Herein, we demonstrate the first example of a pure molecular dynamic crystalline framework held together by means of weak "sticky fingers" van der Waals interactions. Read More

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December 2018

Ultrahigh-Sensitive Broadband Photodetectors Based on Dielectric Shielded MoTe /Graphene/SnS p-g-n Junctions.

Adv Mater 2018 Dec 14:e1805656. Epub 2018 Dec 14.

Department of Physics, Southern University of Science and Technology, Shenzhen, 518055, China.

2D atomic sheets of transition metal dichalcogenides (TMDs) have a tremendous potential for next-generation optoelectronics since they can be stacked layer-by-layer to form van der Waals (vdW) heterostructures. This allows not only bypassing difficulties in heteroepitaxy of lattice-mismatched semiconductors of desired functionalities but also providing a scheme to design new optoelectronics that can surpass the fundamental limitations on their conventional semiconductor counterparts. Herein, a novel 2D h-BN/p-MoTe /graphene/n-SnS /h-BN p-g-n junction, fabricated by a layer-by-layer dry transfer, demonstrates high-sensitivity, broadband photodetection at room temperature. Read More

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December 2018

MEG imaging of recurrent gliomas reveals functional plasticity of hemispheric language specialization.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Biomagnetic Imaging Lab, Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, California.

In patients with gliomas, changes in hemispheric specialization for language determined by magnetoencephalography (MEG) were analyzed to elucidate the impact of treatment and tumor recurrence on language networks. Demonstration of reorganization of language networks in these patients has significant implications on the prevention of postoperative functional loss and recovery. Whole-brain activity during an auditory verb generation task was estimated from MEG recordings in a group of 73 patients with recurrent gliomas. Read More

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December 2018

Probing Distinctive Electron Conduction in Multilayer Rhenium Disulfide.

Adv Mater 2018 Dec 13:e1805860. Epub 2018 Dec 13.

Department of Applied Physics, Sookmyung Women's University, Seoul, 04310, Republic of Korea.

Charge carrier transport in multilayer van der Waals (vdW) materials, which comprise multiple conducting layers, is well described using Thomas-Fermi charge screening (λ ) and interlayer resistance (R ). When both effects occur in carrier transport, a channel centroid migrates along the c-axis according to a vertical electrostatic force, causing redistribution of the conduction centroid in a multilayer system, unlike a conventional bulk material. Thus far, numerous unique properties of vdW materials are discovered, but direct evidence for distinctive charge transport behavior in 2D layered materials is not demonstrated. Read More

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December 2018

Big data analysis of ab Initio molecular integrals in the neglect of diatomic differential overlap approximation.

J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.

Max-Planck-Institut für Kohlenforschung, 45470, Mülheim an der Ruhr, Germany.

Most modern semiempirical quantum-chemical (SQC) methods are based on the neglect of diatomic differential overlap (NDDO) approximation to ab initio molecular integrals. Here, we check the validity of this approximation by computing all relevant integrals for 32 typical organic molecules using Gaussian-type orbitals and various basis sets (from valence-only minimal to all-electron triple-ζ basis sets) covering in total more than 15.6 million one-electron (1-e) and 10. Read More

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December 2018

Activating mutations in the MAP-kinase pathway define non-ossifying fibroma of bone.

J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.

Non-ossifying fibroma, which occasionally results in pathologic fracture, is considered the most common benign and self-limiting lesion of the growing skeleton. By DNA sequencing we have identified hotspot KRAS, FGFR1 and NF1 mutations in 48 of 59 patients (81.4%) with NOF, at allele frequencies ranging from 0. Read More

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December 2018

High-Performance Photoinduced Memory with Ultrafast Charge Transfer Based on MoS /SWCNTs Network Van Der Waals Heterostructure.

Small 2018 Dec 13:e1804661. Epub 2018 Dec 13.

State Key Laboratory for Chemo/Biosensing and Chemometrics, School of Physics and Technology, Wuhan University, Wuhan, 430072, China.

Photoinduced memory devices with fast program/erase operations are crucial for modern communication technology, especially for high-throughput data storage and transfer. Although some photoinduced memories based on 2D materials have already demonstrated desirable performance, the program/erase speed is still limited to hundreds of micro-seconds. A high-speed photoinduced memory based on MoS /single-walled carbon nanotubes (SWCNTs) network mixed-dimensional van der Waals heterostructure is demonstrated here. Read More

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December 2018

Evaluation of artificial heating sources for the thermoregulation of Aldabra giant tortoises (Aldabrachelys gigantea) in Zurich zoo.

Zoo Biol 2018 Nov 22;37(6):458-465. Epub 2018 Nov 22.

Clinic for Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty, University of Zürich, Zurich, Switzerland.

We recorded the thermoregulatory patterns of five Aldabra giant tortoises (Aldabrachelys gigantea) (25-193 kg) during spring (ZRH spring trial), after the installation of a heating area (concrete heat pad and basking lamp) at Zurich Zoo, Switzerland. The measurements were compared to published results on the same tortoises observed prior to the installation of the heater (ZRH summer and winter trials), and on wild tortoises on Aldabra Atoll. The mean environmental temperature outside the heating area was 23. Read More

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November 2018

Hepatitis E virus blood donor NAT screening: as much as possible or as much as needed?

Transfusion 2018 Dec 13. Epub 2018 Dec 13.

Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein- Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

Background: The cost-benefit question of general screening of blood products for the hepatitis E virus (HEV) is currently being discussed. One central question is the need for individual nucleic acid amplification techniques (NAT) screening (ID-NAT) versus minipool NAT screening (MP-NAT) approaches to identify all relevant viremias in blood donors. Here, the findings of ID-NAT versus MP-NAT in pools of 96 samples were compared. Read More

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December 2018

Do lifestyle interventions during pregnancy have the potential to reduce long-term postpartum weight retention? A systematic review and meta-analysis.

Obes Rev 2018 Dec 12. Epub 2018 Dec 12.

Else Kroener-Fresenius Center for Nutritional Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Reducing postpartum weight retention is a promising strategy for addressing the rising prevalence of overweight and obesity in women. This systematic review and meta-analysis explored whether lifestyle interventions during pregnancy have the potential to reduce weight retention at 4 months postpartum and beyond. A search of five electronic databases for randomized controlled trials comparing the effect of weight-related lifestyle interventions beginning in pregnancy on postpartum weight retention to standard prenatal care groups was performed. Read More

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December 2018

Exploring the binding interaction of the by-product of Maillard reaction 5-hydroxymethyl-2-furaldehyde with calf thymus DNA.

J Sci Food Agric 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Food Science and Technology, Nanchang University, 235 Nanjing East Road Nanchang, 330047, China.

Background: 5-Hydroxymethyl-2-furaldehyde (5-HMF), a kind of by-product of Maillard reaction, usually existed in fried and baked food, it may cause potential harm to human body. Here, the interaction between 5-HMF and calf thymus DNA (ctDNA) under physiological buffer (pH 7.4) was studied using multispectroscopic methods combined with multivariate curve resolution-alternating least-squares (MCR-ALS) chemometrics and molecular simulation techniques. Read More

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December 2018

Microcrystal Electron Diffraction (MicroED) for Small-Molecule Structure Determination.

Angew Chem Int Ed Engl 2018 Dec 12. Epub 2018 Dec 12.

Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225, Düsseldorf, Germany.

The development of new methods to analyze and determine molecular structures parallels the ability to accelerate synthetic research. For many decades, single-crystal analysis by X-ray diffraction (SXRD) has been the definitive tool for structural analysis at the atomic level; the drawback, however, is that a suitable single crystal of the analyte needs to be grown. The recent innovation of the crystalline sponge (CS) method allows the microanalysis of compounds simply soaked in a readily prepared CS crystal, thus circumventing the need to screen crystallization conditions while also using only a trace amount of the sample. Read More

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December 2018

Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro-RNA signature in CABG patients.

Acta Anaesthesiol Scand 2018 Dec 11. Epub 2018 Dec 11.

Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Germany.

Background: Remote ischaemic preconditioning (RIPC) can attenuate myocardial ischaemia/reperfusion injury but its underlying mechanisms remain largely unknown. Recently, extracellular vesicles (EVs) containing microRNAs (miRNAs) were shown to mediate distant intercellular communication that may be involved in cardioprotection. We tested the hypothesis that RIPC in anaesthetized patients undergoing coronary artery bypass (CABG) surgery results in the release of EVs from the ischaemic/reperfused arm into the blood stream harbouring cardioprotective miRNAs. Read More

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December 2018

Reversible Optical Writing and Data Storage in an Anthracene-Loaded Metal-Organic Framework.

Angew Chem Int Ed Engl 2018 Dec 11. Epub 2018 Dec 11.

Katholieke Universiteit Leuven, Microbial and Molecular Systems, Celestijnenlaan 200 F, 3001 , Leuven, BELGIUM.

Metal-organic frameworks (MOFs) enable the design of host-guest systems with specific properties. In this work, we show how confinement of anthracene in a well-chosen MOF host leads to reversible yellow-to-purple photoswitching of the fluorescence emission. This behavior has not been observed before for anthracene, either in pure form or adsorbed in other porous hosts. Read More

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December 2018

High-pressure behaviour of Prussian blue analogues: interplay of hydration, Jahn-Teller distortions and vacancies.

Dalton Trans 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford OX1 3QR, UK.

We report a high-pressure crystallographic study of four hydrated Prussian blue analogues: M[Pt(CN)6] and M[Co(CN)6]0.67 (M = Mn2+, Cu2+) in the range 0-3 GPa. Mn[Co(CN)6]0. Read More

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December 2018

Daphnia galeata responds to the exposure to an ichthyosporean gut parasite by down-regulation of immunity and lipid metabolism.

BMC Genomics 2018 Dec 14;19(1):932. Epub 2018 Dec 14.

Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Berlin, Germany.

Background: Regulatory circuits of infection in the emerging experimental model system, water flea Daphnia and their microparasites, remain largely unknown. Here we provide the first molecular insights into the response of Daphnia galeata to its highly virulent and common parasite Caullerya mesnili, an ichthyosporean that infects the gut epithelium. We generated a transcriptomic dataset using RNAseq from parasite-exposed (vs. Read More

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December 2018

[Career prospects of graduate Bachelor nursing degree programs - Results of a nationwide study in Germany].

Pflege 2018 Dec 14:1-10. Epub 2018 Dec 14.

2 Institut für Pflegewissenschaft, Medizinische Fakultät der Albert-Ludwigs-Universität, Freiburg i. B.

Career prospects of graduate Bachelor nursing degree programs - Results of a nationwide study in Germany Abstract.

Background: Graduates of Bachelor nursing degree programs are available on the labour market for a few years. Currently, there is no empirical evidence or reports on different fields of these academically prepared nurses in Germany. Read More

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December 2018