115,822 results match your criteria Der Chirurg; Zeitschrift fuer alle Gebiete der operativen Medizen[Journal]


[Use of Negative Pressure Wound Therapy with Instillation and Dwell Time for Wound Treatment - Results of an Expert Consensus Conference].

Zentralbl Chir 2018 Dec 11;143(6):609-616. Epub 2018 Dec 11.

Unfallchirurgie, Bundeswehrkrankenhaus Berlin, Deutschland.

Rinsing wounds with wound cleansing solutions has long been a recognised cornerstone in wound management as a means of removing cell debris and surface pathogens in wound exudates. In combination with surgical debridement and topical negative pressure wound therapy (NPWT), this can facilitate the intended progression from the inflammatory to the proliferative phase of wound healing. Procedures of topical negative pressure wound therapy with instillation and a defined exposure/dwell-time of topical solutions under cyclic compression and decompression with foam dressings (NPWTi-d) can remove cellular remnants and debris that may inhibit the healing process. Read More

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December 2018
1 Read

[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018

[Coercion and aggression in psychiatry: the individual psychological dimension of aggressive and coercive acts by therapists].

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik für Psychiatrie, Psychotherapie und Präventivmedizin, LWL-Universitätsklinikum der Ruhr-Universität Bochum.

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December 2018

Diabetes-induced neuropathic mechanical hyperalgesia depends on P2X4 receptor activation in Dorsal Root Ganglia.

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address:

Peripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are evidences that the activation of the P2X4 receptor (P2X4R) expressed on microglial cells of the central nervous system takes part in the development of neuropathic pain. Read More

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December 2018
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Update Dermatologische Lasertherapie 2018 I - Epilation, Gefäße und Pigmente.

J Dtsch Dermatol Ges 2018 Dec;16(12):1417-1424

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig AöR und Medizinische Fakultät der Universität Leipzig.

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December 2018

Rezidivierendes akutes hämorrhagisches Ödem des Kindesalters (AHEI) in der Pubertät.

J Dtsch Dermatol Ges 2018 Dec;16(12):1496-1498

Abteilung für Translationale Dermatoinfektiologie, Universitätsklinikum Münster.

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December 2018

Patientencharakteristika der dermatologischen Notfallambulanz an einer Universitätsklinik in Deutschland.

J Dtsch Dermatol Ges 2018 Dec;16(12):1451-1458

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg und Medizinische Fakultät, Universität Freiburg, Deutschland.

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December 2018

Nomenklatur der kutanen Vaskulitiden - deutschsprachige Definitionen des Dermatologischen Anhanges zur Chapel Hill Consensus Conference.

J Dtsch Dermatol Ges 2018 Dec;16(12):1425-1433

Klinik für Dermatologie und Venerologie, Universitätsklinik Innsbruck, Innsbruck, Österreich.

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December 2018

Sequenzielles Auftreten einer primären und sekundären Hypothyreose unter Therapie mit Nivolumab: Fallstricke in der immunonkologischen Therapie und endokrinologischen Diagnostik.

J Dtsch Dermatol Ges 2018 Dec;16(12):1483-1485

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg und Medizinische Fakultät, Universität Freiburg.

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December 2018

IL-37 alleviates house dust mite-induced chronic allergic asthma by targeting TSLP through the NF-κB & ERK1/2 signaling pathways.

Immunol Cell Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pulmonary Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Institute of Respiratory Diseases of Sun Yat, Sen University, Guangzhou, China.

Interleukin (IL)-37 has been described as a negative regulator of immune responses and is critical for asthma pathogenesis, but the mechanisms behind the protective role of IL-37 against allergic asthma are less well understood. We show here that IL-37 administered intranasally (i.n. Read More

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December 2018

Site-Selective and van der Waals Epitaxial Growth of Rhenium Disulfide on Graphene.

Small 2018 Dec 11:e1804133. Epub 2018 Dec 11.

Department of Energy Engineering, School of Energy and Chemical Engineering, Low Dimensional Carbon Materials Center, Perovtronics Research Center, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

The surface property of growth substrate imposes significant influence in the growth behaviors of 2D materials. Rhenium disulfide (ReS ) is a new family of 2D transition metal dichalcogenides with unique distorted 1T crystal structure and thickness-independent direct bandgap. The role of growth substrate is more critical for ReS owing to its weak interlayer coupling property, which leads to preferred growth along the out-of-plane direction while suppressing the uniform in-plane growth. Read More

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December 2018
3 Reads

The diversity of population responses to environmental change.

Ecol Lett 2018 Dec 9. Epub 2018 Dec 9.

Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France.

The current extinction and climate change crises pressure us to predict population dynamics with ever-greater accuracy. Although predictions rest on the well-advanced theory of age-structured populations, two key issues remain poorly explored. Specifically, how the age-dependency in demographic rates and the year-to-year interactions between survival and fecundity affect stochastic population growth rates. Read More

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December 2018

Continued use of poliovirus after eradication: hyper-attenuated strains as a safe alternative for release testing of human immunoglobulins.

Transfusion 2018 Dec;58 Suppl 3:3084-3089

Global Pathogen Safety, Vienna, Austria.

Background: Wild-type poliovirus may be eradicated soon and under WHO GAPIII guidance, laboratory use will be discontinued or subject to strict containment. Per US Code of Federal Regulations, however, immunoglobulin lot release testing will still require use of replicating poliovirus. The suitability of S19 hyper-attenuated and apathogenic poliovirus strains as alternatives to the currently used wild-type virus in such a release assay was investigated. Read More

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December 2018

[Speech and Language Disorders in the Elderly].

Authors:
Arno Olthoff

Laryngorhinootologie 2018 Dec 10;97(12):846-851. Epub 2018 Dec 10.

Phoniatrie und Pädaudiologie Göttingen, Klinik für Hals-, Nasen- und Ohrenheilkunde.

Cerebrovascular insults and neurodegenerative diseases are the main causes of acquired speech and language disorders. A massive increase in the prevalence of both is evident from the age of 65 years. By the age of 90 years, more than 10 % of the population would have experienced a stroke and 30 % would have suffered from neurodegenerative diseases. Read More

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December 2018

Der Stimmlippenpolyp.

Authors:
Tadeus Nawka

Laryngorhinootologie 2018 Dec 10;97(12):836-837. Epub 2018 Dec 10.

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December 2018

[Registry Research Funding of the German Society of Plastic, Reconstructive and Aesthetic Surgeons (DGPRÄC) and Research Funding Report 2017/2018].

Handchir Mikrochir Plast Chir 2018 Dec 10. Epub 2018 Dec 10.

Klinik und Poliklinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinische Hochschule Hannover.

Introduction: This report serves to publicize the research of academic institutions for Plastic Surgery within our society DGPRÄC in 2017/2018 and sequels the funding report of 2015/2016. Applications to public, non-public, or industrial funding organizations were evaluated. At the same time, this paper analyses the number of approved DFG applications in Plastic, Thoracic and Vascular Surgery in the GEPRIS system. Read More

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December 2018

Hyperplastic polyps and nonadvanced adenomas, but not advanced polypoid lesions, are detected more frequently in the presence of colonic diverticula during screening colonoscopies.

Z Gastroenterol 2018 Dec 10;56(12):1475-1480. Epub 2018 Dec 10.

Department of Gastroenterology and Hepatology, University Hospital Cologne, Germany.

Hintergrund:  Die bisher veröffentlichte Studienlage zur Assoziation von Kolondivertikeln und kolorektalen Polypen einschließlich des kolorektalen Karzinoms (KRK) ist konträr. Ziel der Studie war es, die Assoziation für sämtliche relevanten histologischen Polypensubtypen, d. h. Read More

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December 2018

[Medicine and Economy Today].

Authors:
S Ewig

Pneumologie 2018 Dec 7. Epub 2018 Dec 7.

Thoraxzentrum Ruhrgebiet, Bochum.

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December 2018

[A Pioneer of Anatomy - Dryander of Marburg (1500 -1560) and the Anatomic Illustration of the Lung].

Authors:
U Koehler

Pneumologie 2018 Dec 7. Epub 2018 Dec 7.

Klinik für Innere Medizin, SP Pneumologie, Intensiv- und Schlafmedizin, Philipps-Universität, Marburg.

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December 2018

Tunable Electric Properties of Bilayer α-GeTe with Different Interlayer Distances and External Electric Fields.

Nanoscale Res Lett 2018 Dec 7;13(1):400. Epub 2018 Dec 7.

Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, and School of Physics and Technology, Wuhan University, Wuhan, 430072, China.

Based on first-principle calculations, the stability, electronic structure, optical absorption, and modulated electronic properties by different interlayer distances or by external electric fields of bilayer α-GeTe are systemically investigated. Results show that van der Waals (vdW) bilayer α-GeTe has an indirect band structure with the gap value of 0.610 eV, and α-GeTe has attractively efficient light harvesting. Read More

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December 2018
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CONFINE-MAS: a magic-angle spinning NMR probe that confines the sample in case of a rotor explosion.

J Biomol NMR 2018 Dec 10. Epub 2018 Dec 10.

Physical Chemistry, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zürich, Switzerland.

Magic-angle spinning (MAS) is mandatory in solid-state NMR experiments to achieve resolved spectra. In rare cases, instabilities in the rotation or damage of either the rotor or the rotor cap can lead to a so called "rotor crash" involving a disintegration of the sample container and possibly the release of an aerosol or of dust. We present a modified design of a 3. Read More

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December 2018

Understanding negative biodiversity-ecosystem functioning relationship in semi-natural wildflower strips.

Oecologia 2018 Dec 7. Epub 2018 Dec 7.

Department of Biology, Ecology and Evolution, University of Fribourg, Chemin du Musée 10, 1700, Fribourg, Switzerland.

Studies on biodiversity-ecosystem functioning (BEF) in highly controlled experiments often yield results incompatible with observations from natural systems: experimental results often reveal positive relationships between diversity and productivity, while for natural systems, zero or even negative relationships have been reported. The discrepancy may arise due to a limited or closed local species pool in experiments, while natural systems in meta-community contexts experience dynamic processes, i.e. Read More

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December 2018

Preliminary validation of the Simplified Psoriatic Arthritis Radiographic Score (SPARS).

Skeletal Radiol 2018 Dec 7. Epub 2018 Dec 7.

Radiology Department, Università Politecnica delle Marche, Ancona, Italy.

Objective: To develop and validate in a preliminary way a novel radiographic scoring system for psoriatic arthritis (PsA), called Simplified Psoriatic Arthritis Radiographic Score (SPARS).

Materials And Methods: Radiographs of hands and feet were obtained from consecutive PsA patients and assessed by two readers. For each joint (30 joints in the hands, ten joints in the feet), the combination of the erosions, joint narrowing space (JNS) and bony proliferation (BP) has been assessed, giving a value of 1 for erosions presence, 1 for JNS presence, and 1 for BP presence (SPARS score range, 0-120). Read More

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December 2018

[The trend towards full-endoscopic decompression : Current possibilities and limitations in disc herniation and spinal stenosis].

Authors:
S Ruetten M Komp

Orthopade 2018 Dec 7. Epub 2018 Dec 7.

Zentrum für Wirbelsäulenchirurgie und Schmerztherapie, Zentrum für Orthopädie und Unfallchirurgie der St. Elisabeth Gruppe - Katholische Kliniken Rhein-Ruhr, St. Anna Hospital Herne/Universitätsklinikum, Marien Hospital Herne/Marien Hospital Witten, Hospitalstr. 19, 44649, Herne, Deutschland.

Background: The most frequent causes of degenerative constrictions of the spinal canal are disk herniations and spinal stenoses. The lumbar and cervical spine is the most affected.

Surgical Procedures: After conservative treatments have been exhausted, surgical intervention may be necessary. Read More

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December 2018

Retrograde fixation of the lesser trochanter in the adolescent: new surgical technique and clinical results of two cases.

Arch Orthop Trauma Surg 2018 Dec 10. Epub 2018 Dec 10.

Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Introduction: Avulsions of the lesser femoral trochanter are rare injuries in the adolescent population. An acute avulsion causes severe functional impairment with compromised hip flexion. Recent literature reports the superiority of surgical treatment for apophyseal avulsion fractures of the pelvis in adolescents. Read More

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December 2018

Schema-related cognitive load influences performance, speech, and physiology in a dual-task setting: A continuous multi-measure approach.

Cogn Res Princ Implic 2018 Dec 7;3(1):46. Epub 2018 Dec 7.

Psychology of Learning with Digital Media, Institute for Media Research, Faculty of Humanities, TU Chemnitz, Straße der Nationen 12, 09111, Chemnitz, Germany.

Schema acquisition processes comprise an essential source of cognitive demands in learning situations. To shed light on related mechanisms and influencing factors, this study applied a continuous multi-measure approach for cognitive load assessment. In a dual-task setting, a sample of 123 student participants learned visually presented symbol combinations with one of two levels of complexity while memorizing auditorily presented number sequences. Read More

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December 2018

Kidney toxicity and response of selenium containing protein-glutathione peroxidase (Gpx3) to CdTe QDs on different levels.

Toxicol Sci 2018 Dec 10. Epub 2018 Dec 10.

School of Environmental Science and Engineering, Shandong University, China -America CRC for Environment & Health, Shandong Province, 72# Jimo Binhai Road, Qingdao, Shandong, P.R. China.

The toxic mechanism of cadmium-quantum dot (Cd-QDs) to organisms is still debating. In this paper, it was found that Cd-QDs could induce adverse effects to kidney by entering into cells in a time and dose manner and disturbing the redox balance in vivo. As a selenium containing protein, glutathione peroxidase3 (Gpx3) plays a crucial role in maintaining the balance of redox system. Read More

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December 2018

Frequency and characteristics of MODY 1 (HNF4A mutation) and MODY 5 (HNF1B mutation) - Analysis from the DPV database.

J Clin Endocrinol Metab 2018 Dec 10. Epub 2018 Dec 10.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany.

Objective: To characterize initial presentation and clinical course of patients with rare HNF4A- and HNF1B-MODY in a large multinational registry.

Design, Setting And Participants: Within the DPV (Diabetes Patienten Verlaufsdokumentation) registry, 44 patients with HNF4A- and 35 patients with HNF1B-MODY were characterized and compared to type 1 diabetes (T1D) / type 2 diabetes (T2D) in patients < 20 years.

Main Outcome Measure: Clinical and laboratory parameters, therapy, and quality of metabolic control, extrapancreatic symptoms in HNF1B-MODY patients. Read More

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December 2018

Neuronal photoactivation through second-harmonic near-infrared absorption by gold nanoparticles.

Light Sci Appl 2018 5;7:100. Epub 2018 Dec 5.

1NeuroTechnology Center, Department of Biological Sciences, Columbia University, New York, NY 10027 USA.

Optical activation of neurons requires genetic manipulation or the use of chemical photoactivators with undesirable side effects. As a solution to these disadvantages, here, we demonstrate optically evoked neuronal activity in mouse cortical neurons in acute slices and in vivo by nonlinear excitation of gold nanoparticles. In addition, we use this approach to stimulate individual epitheliomuscular cells and evoke body contractions in . Read More

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December 2018

Comparison of microbiota and allergen profile in house dust from homes of allergic and non-allergic subjects- results from the GUSTO study.

World Allergy Organ J 2018 5;11(1):37. Epub 2018 Dec 5.

1Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.

Background: The prevalence of allergic diseases, such as asthma, allergic rhinitis, eczema and food allergy, has been increasing worldwide, as shown in a large number of studies, including the International Study of Asthma and Allergies in Childhood (ISAAC). However, there is significant variation in the prevalence of these diseases in different regions, suggesting that there may be location-specific factors such as environment and microbial exposure affecting allergic disease prevalence. Hence, in this study we determine if there is a difference in microbiota composition and allergen concentration of household dust collected from the homes of non-allergic and allergic subjects from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort. Read More

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December 2018

K-edge subtraction imaging for coronary angiography with a compact synchrotron X-ray source.

PLoS One 2018 10;13(12):e0208446. Epub 2018 Dec 10.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

About one third of all deaths worldwide can be traced back to cardiovascular diseases. An interventional radiology procedure for their diagnosis is Digital Subtraction Angiography (DSA). An alternative to DSA is K-Edge subtraction (KES) imaging, which has been shown to be advantageous for moving organs and eliminating image artifacts caused by patient movement. Read More

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December 2018

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways.

Sci Rep 2018 Dec 7;8(1):17702. Epub 2018 Dec 7.

Laboratory for Biomedical Neurosciences, Neurocenter of Southern Switzerland, Ente Cantonale Ospedaliero, Torricella-Taverne, Switzerland.

Post-translational protein modification controls the function of Tau as a scaffold protein linking a variety of molecular partners. This is most studied in the context of microtubules, where Tau regulates their stability as well as the distribution of cellular components to defined compartments. However, Tau is also located in the cell nucleus; and is found to protect DNA. Read More

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December 2018

Strong improvement of the transport characteristics of YBaCuO grain boundaries using ionic liquid gating.

Authors:
A Fête C Senatore

Sci Rep 2018 Dec 7;8(1):17703. Epub 2018 Dec 7.

Department of Quantum Matter Physics (DQMP), University of Geneva, Geneva, Switzerland.

For more than 30 years, the remarkable superconducting properties of REBaCuO (RE = rare earth) compounds have triggered research studies across the world. Accordingly, significant progresses have been made both from a basic understanding and a fabrication processes perspective. Yet, today, the major technological bottleneck towards the spread of their practical uses remains the exponential decay of their critical current with grain misorientation in polycrystalline samples. Read More

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December 2018

Vertical WS/SnS van der Waals Heterostructure for Tunneling Transistors.

Sci Rep 2018 Dec 10;8(1):17755. Epub 2018 Dec 10.

Key Laboratory of Microelectronic Devices and Circuits (MOE), Institute of Microelectronics, Peking University, Beijing, 100871, China.

Van der Waals heterostructures composed of two-dimensional (2D) transition metal dichalcogenides (TMD) materials have stimulated tremendous research interest in various device applications, especially in energy-efficient future-generation electronics. Such ultra-thin stacks as tunnel junction theoretically present unprecedented possibilities of tunable relative band alignment and pristine interfaces, which enable significant performance enhancement for steep-slope tunneling transistors. In this work, the optimal 2D-2D heterostructure for tunneling transistors is presented and elaborately engineered, taking into consideration both electric properties and material stability. Read More

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December 2018
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Duration of Scar Maturation: Retrospective Analyses of 361 Hypertrophic Scars Over 5 Years.

Adv Skin Wound Care 2018 Dec 7. Epub 2018 Dec 7.

In the Department of Plastic Surgery, Maastricht University Medical Center, the Netherlands, Sander Kant, MD, is a researcher; Eric van den Kerckhove, Prof, is a physiotherapist; Carlo Colla, is orthotist/prosthetist; René van der Hulst, Prof Dr, is plastic surgeon; and Andrzej A. Piatkowski de Grzymala, MD, is plastic surgeon.

Objective: Maturation remains the least understood phase of wound healing; estimates of maturation time are broad and inaccurate. A more precise estimation of maturation time could influence scar therapy and give insight to the wound healing cascade. The objective of this study was to assess the mean time between onset and complete maturation of hypertrophic scars. Read More

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December 2018

Atomically thin van der waals tunnel field-effect transistors and its potential for applications.

Nanotechnology 2018 Dec 10. Epub 2018 Dec 10.

Physics, National Chung Hsing University, Taichung, TAIWAN.

Power dissipation is a crucial problem as the packing density of transistors increases in modern integrated circuits. Tunnel field-effect transistors (TFETs), which have high energy filtering provided by band-to-band tunneling (BTBT), have been proposed as an alternative electronics architecture to decrease the energy loss in bias operation and to achieve steep switching at room temperature. Very recently, the BTBT behavior has been demonstrated in van der Waals heterostructures by using unintentionally doped semiconductors. Read More

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December 2018

Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance.

J Clin Pathol 2018 Dec 8. Epub 2018 Dec 8.

Institute of Pathology, Technical University of Munich (TUM), Munich, Germany.

Aims: Squamous cell carcinoma of the oral cavity (OSCC) is a common tumour entity with a variable, partially highly aggressive clinical course. Recently, we proposed a novel (three-tiered) clinically useful grading scheme strongly associated with patient outcome in OSCC, consisting of a sum score of the histomorphological patterns tumour budding and cell nest size which outperforms WHO based grading algorithms currently in use. The aim of our study was to probe for interobserver and intraobserver reliability of this novel grading system. Read More

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December 2018
1 Read

Composition and Clinical Impact of the Immunologic Tumor Microenvironment in Oral Squamous Cell Carcinoma.

J Immunol 2018 Dec 10. Epub 2018 Dec 10.

Department of Oral and Maxillofacial Surgery, Rechts der Isar Hospital, Technical University of Munich, 81675 Munich, Germany;

Immunotherapy shows promising results and revolutionizes treatment of oral squamous cell carcinoma (OSCC). The immunologic microenvironment might have prognostic/predictive implications. Morphologic immunologic parameters (inflammatory infiltrate, stromal content, and budding activity [BA] [potentially indicating epithelial-mesenchymal transition]) were evaluated in 66 human primary therapy-naive OSCCs. Read More

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December 2018

Multi-omics and potential applications in wine production.

Curr Opin Biotechnol 2018 Dec 7;56:172-178. Epub 2018 Dec 7.

Section for Evolutionary Genomics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark; Norwegian University of Science and Technology, University Museum, Trondheim, Norway. Electronic address:

The wine microbiome - that is the microbial communities associated with the fermentation of must, is one of the most important factors in transforming grapes to wine, including flavour and aroma. Recent developments in high throughput sequencing and other 'omics methodologies are rapidly changing the level and complexity of information that we are able to extract from the wine microbiome. This will significantly enhance not only our understanding of which microbes are present at the various stages of the grapevine growth and winemaking process, but also improve our understanding of the complex interactions between microbes, the substrate and environment, ultimately shaping wine production. Read More

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December 2018
1 Read

SWITCH II: Phase III randomized, sequential, open-label study to evaluate the efficacy and safety of sorafenib-pazopanib versus pazopanib-sorafenib in the treatment of advanced or metastatic renal cell carcinoma (AUO AN 33/11).

Eur J Cancer 2018 Dec 6;107:37-45. Epub 2018 Dec 6.

Dept. of Urology, Rechts der Isar Medical Center, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; AUO Study Group, Germany. Electronic address:

Purpose: This trial compared the sequential therapy with the multikinase inhibitor sorafenib (So) followed by pazopanib (Pa) or vice versa in advanced/metastatic renal cell carcinoma (mRCC) patients.

Methods: This multicenter, randomized phase 3 study assessed the sequential use of So-Pa versus Pa-So in patients with mRCC without prior systemic therapy. Pts were randomized to So 2 × 400 mg/day followed by Pa 1 × 800 mg/day in case of progression or intolerable toxicity or vice versa. Read More

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December 2018

Relationship of critical dynamics, functional connectivity, and states of consciousness in large-scale human brain networks.

Neuroimage 2018 Dec 6. Epub 2018 Dec 6.

Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, United States; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI, United States. Electronic address:

Recent modeling and empirical studies support the hypothesis that large-scale brain networks function near a critical state. Similar functional connectivity patterns derived from resting state empirical data and brain network models at criticality provide further support. However, despite the strong implication of a relationship, there has been no principled explanation of how criticality shapes the characteristic functional connectivity in large-scale brain networks. Read More

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December 2018

Role of Der p 1-specific B cells in immune tolerance during 2-year house dust mite-specific immunotherapy.

J Allergy Clin Immunol 2018 Dec 5. Epub 2018 Dec 5.

Swiss Institute of Allergy and Asthma Research (SIAF), University Zurich, Davos, Switzerland. Electronic address:

Background: Long-term follow-up of allergen-specific B cells in terms of immunoglobulin isotype expression, plasmablasts differentiation and regulatory B cell (Breg) development during allergen-specific immunotherapy (AIT) has not been reported.

Objective: Allergen-specific B cell responses during 2-years house dust mite (HDM) AIT were compared between responder and non-responder patients.

Methods: B cells specific for the Der p 1 were detected using fluorochrome-labeled allergen method. Read More

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December 2018

What are the determinants of children's sleep behavior? A systematic review of longitudinal studies.

Sleep Med Rev 2018 Nov 12;43:60-70. Epub 2018 Nov 12.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Van der Boechorststraat 7, NL-1081 BT, Amsterdam, the Netherlands.

To develop evidence-based healthy sleep interventions for children, this review provides insight into the behavioral determinants of sleep behavior. Hence the objective of this review is to systematically review the longitudinal evidence on determinants of children's sleep behavior. Studies were identified from searches in PubMed, PsycINFO, and Web of Science, until January 2017. Read More

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November 2018

Optimization of viability qPCR for selective detection of membrane-intact Legionella pneumophila.

J Microbiol Methods 2018 Dec 5. Epub 2018 Dec 5.

IWW Water Centre, Applied Microbiology, Moritzstrasse 26, 45476 Mülheim an der Ruhr, Germany. Electronic address:

Although a number of viability qPCR assays have been reported to selectively detect signals from membrane-intact Legionella pneumophila, the efficient suppression of amplification of DNA from dead membrane-compromised bacteria remains an ongoing challenge. This research aimed at establishing a new oligonucleotide combination that allows for a better exclusion of dead Legionella pneumophila on basis of the mip gene. Propidium monoazide (PMA) was chosen as viability dye. Read More

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December 2018

Neurocognitive and neuroanatomical maturation in the clinical high-risk states for psychosis: A pattern recognition study.

Neuroimage Clin 2018 Dec 3. Epub 2018 Dec 3.

Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, Germany.

Background: Findings from neurodevelopmental studies indicate that adolescents with psychosis spectrum disorders have delayed neurocognitive performance relative to the maturational state of their healthy peers. Using machine learning, we generated a model of neurocognitive age in healthy adults and investigated whether individuals in clinical high risk (CHR) for psychosis showed systematic neurocognitive age deviations that were accompanied by specific structural brain alterations.

Methods: First, a Support Vector Regression-based age prediction model was trained and cross-validated on the neurocognitive data of 36 healthy controls (HC). Read More

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December 2018

The effect of Pyrroloquinoline quinone and Resveratrol on the Survival and Regeneration of Cerebellar Granular Neurons.

Neurosci Lett 2018 Dec 5. Epub 2018 Dec 5.

Department of Biochemistry, German University in Cairo, Egypt. Electronic address:

The inability of central nervous system (CNS) to regenerate following traumatic brain injury (TBI) can be attributed to apoptotic cell death, inhibitory extrinsic environment and the limited ability of neurons to regenerate. Thus, fostering the intrinsic regenerative potential and minimizing neuronal cell death could be a promising therapeutic approach. Pyrroloquinoline quinone (PQQ) was previously reported for its neuroprotective and regenerative potential on peripheral nerves. Read More

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December 2018
1 Read

Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 4. Epub 2018 Dec 4.

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.

Introduction: Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators here collectively named oxylipins. These include classical eicosanoids, but also pro-resolving mediators. Read More

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December 2018

Wounding-Induced Stomatal Closure Requires Jasmonate-Mediated Activation of GORK K Channels by a Ca Sensor-Kinase CBL1-CIPK5 Complex.

Dev Cell 2018 Dec 3. Epub 2018 Dec 3.

Molekulare Pflanzenphysiologie & Biophysik, Julius-Maximilians-Universität Würzburg, Julius-von-Sachs-Platz 2, Würzburg 97082, Germany. Electronic address:

Guard cells integrate various hormone signals and environmental cues to balance plant gas exchange and transpiration. The wounding-associated hormone jasmonic acid (JA) and the drought hormone abscisic acid (ABA) both trigger stomatal closure. In contrast to ABA however, the molecular mechanisms of JA-induced stomatal closure have remained largely elusive. Read More

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December 2018