407,594 results match your criteria Depression


A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions.

Genes (Basel) 2019 Feb 13;10(2). Epub 2019 Feb 13.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.

Post-traumatic stress disorder (PTSD) is an acquired psychiatric disorder with functionally impairing physiological and psychological symptoms following a traumatic exposure. Genetic, epigenetic, and environmental factors act together to determine both an individual's susceptibility to PTSD and its clinical phenotype. In this literature review, we briefly review the candidate genes that have been implicated in the development and severity of the PTSD phenotype. Read More

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http://dx.doi.org/10.3390/genes10020140DOI Listing
February 2019

Association between Lower Intake of Minerals and Depressive Symptoms among Elderly Japanese Women but Not Men: Findings from Shika Study.

Nutrients 2019 Feb 13;11(2). Epub 2019 Feb 13.

Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan.

The aim of this cross-sectional study was to examine the relationship of mineral intake, including sodium, potassium, calcium, magnesium, phosphorus, iron, zinc, copper and manganese, with depressive symptoms in both genders in the Japanese elderly population. A total of 1423 participants who were older than 65 years old were recruited in this study. Mineral intake was analyzed using a validated and brief self-administered diet history questionnaire. Read More

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http://dx.doi.org/10.3390/nu11020389DOI Listing
February 2019

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses.

Diseases 2019 Feb 13;7(1). Epub 2019 Feb 13.

Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.

Psychiatric illnesses may be qualified to the cellular impairments of the function for survival or death in neurons, which may consequently appear as abnormalities in the neuroplasticity. The molecular mechanism has not been well understood, however, it seems that PI3K, AKT, GSK3, and their downstream molecules have crucial roles in the pathogenesis. Through transducing cell surviving signal, the PI3K/AKT/GSK3 pathway may organize an intracellular central network for the action of the synaptic neuroplasticity. Read More

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http://dx.doi.org/10.3390/diseases7010022DOI Listing
February 2019

Using Eye Tracking to Explore Facebook Use and Associations with Facebook Addiction, Mental Well-being, and Personality.

Behav Sci (Basel) 2019 Feb 18;9(2). Epub 2019 Feb 18.

College of Life and Natural Sciences, School of Human Sciences, University of Derby, Derby DE22 1GB, UK.

Social networking sites (SNSs) have become ubiquitous in our everyday lives, and for all its communicative benefits, excessive SNS use has been associated with a range of negative health implications. In the present study, the authors use eye-tracking methodology to explore the relationship between individual differences in personality, mental well-being, SNS usage, and the focus of Facebook users' visual attention. Participants ( = 69, mean age = 23. Read More

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http://dx.doi.org/10.3390/bs9020019DOI Listing
February 2019

Brain Aging and Gut⁻Brain Axis.

Authors:
M Hasan Mohajeri

Nutrients 2019 Feb 18;11(2). Epub 2019 Feb 18.

Department of human medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

In the last decade, the microbiome in general and the gut microbiome in particular have been associated not only to brain development and function, but also to the pathophysiology of brain aging and to neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, or multiple sclerosis (MS) [... Read More

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http://dx.doi.org/10.3390/nu11020424DOI Listing
February 2019

The Effect of the Treatment at a Pain Clinic on the Patients' Assessment of Their Pain Intensity and the Incidence of Mental Disorders in the form of Anxiety, Depression, and Aggression.

Int J Environ Res Public Health 2019 Feb 18;16(4). Epub 2019 Feb 18.

Department of Anesthesiology and Intensive Care, John Paul II Western Hospital in Grodzisk Mazowiecki, 11 Daleka St., 05-825 Grodzisk Mazowiecki, Poland.

The aim of the study was to analyze the effect of the treatment given to patients in a pain clinic on their assessment of pain intensity and the incidence of emotional disturbances in the form of anxiety, depression, and aggression. The study was conducted from January 2014 to April 2018 among patients under the care of two Warsaw pain clinics. The study tools were the Hospital Anxiety and Depression Scale-Modified Version (HADS-M) and the Numerical Rating Scale (NRS). Read More

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http://dx.doi.org/10.3390/ijerph16040586DOI Listing
February 2019
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Efficacy of vortioxetine combined cognitive behaviour intervention therapy on brain-derived neurotrophic factor level on depressive patients.

Psychogeriatrics 2019 Feb 19. Epub 2019 Feb 19.

School of Humanities and Social Sciences, Harbin Medical University, Harbin, China.

Background: To evaluate the effect of vortioxetine combined with cognitive behaviour intervention on the level of brain-derived neurotrophic factor (BDNF) in the serum of patients with depression and its therapeutic effect.

Methods: A total of 82 depressive patients treated at the School of Basic Medicine, Heilongjiang University of Chinese Medicine from January 2017 to June 2017 were randomised into a control group (n = 41) and intervention group (n = 41) according to a random number table. Both groups were given vortioxetine treatment, while the intervention group adopted an additional cognitive-behavioural therapy at the same time. Read More

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http://dx.doi.org/10.1111/psyg.12426DOI Listing
February 2019

Complex cardiac vagal regulation to mental and physiological stress in adolescent major depression.

J Affect Disord 2019 Feb 13;249:234-241. Epub 2019 Feb 13.

Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4C, 036 01 Martin, Slovak Republic; Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4C, 036 01 Martin, Slovak Republic. Electronic address:

Background: Cardiovagal control is known to be reduced in major depressive disorder (MDD), however, the neurocardiac reflex control to distinct types of stressors is still unclear. We aimed to study parasympathetically mediated cardiac reflex functioning in response to mental and physiological stressors using heart rate variability (HRV) linear and nonlinear analysis in adolescent MDD.

Methods: We examined 60 adolescents (40 girls) with MDD (age 14. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.043DOI Listing
February 2019

Research progress on classical traditional Chinese medicine formula Lily Bulb and Rehmannia Decoction in the treatment of depression.

Biomed Pharmacother 2019 Feb 16;112:108616. Epub 2019 Feb 16.

Shandong Co-Innovation Center of Classic TCM formula, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China. Electronic address:

Depression pertains to the category of "Emotional Diseases" in traditional Chinese medicine (TCM). Its clinical symptoms are similar to the manifestations of "lily disease" from the TCM classics Synopsis of the Golden Chamber written by Zhang Zhongjing in the Han Dynasty. Also in this book, Lily Bulb and Rehmannia Decoction (LBRD) is the formula for the treatment of "lily disease". Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108616DOI Listing
February 2019

The influence of attachment style and relationship quality on quality of life and psychological distress in carers of people with epileptic and nonepileptic seizures.

Epilepsy Behav 2019 Feb 16;93:16-21. Epub 2019 Feb 16.

Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom; Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, United Kingdom.

Background: Seizure disorders affect not only the individual living with seizures, but also those caring for them. Carer-patient relationships may be influenced by, and have an influence on, some aspects of living with seizure disorders - with potentially different interactions seen in epilepsy and psychogenic nonepileptic seizures (PNES).

Objectives: We studied the influence of patient and carer attachment style and relationship quality on carer wellbeing and psychological distress, and explored whether these associations differ between carers for people with epilepsy and for those with PNES. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.028DOI Listing
February 2019

The unique associations between self-compassion and eating disorder psychopathology and the mediating role of rumination.

Psychiatry Res 2019 Feb 8;274:91-97. Epub 2019 Feb 8.

Department of Psychology, The College of New Jersey, Ewing, NJ, United States.

Mindfulness reduces eating disorder (ED) psychopathology. Self-compassion is a related but distinct construct that may predict other clinical outcomes more strongly than does mindfulness. Previous evidence suggests that self-compassion is associated with less ED psychopathology, although no studies have compared the unique effects of self-compassion and mindfulness. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.02.019DOI Listing
February 2019

Pharmacological evidence for the relationship between the NMDA receptor and nitric oxide pathway and the antidepressant-like effects of glucagon-like peptide-2 in the mouse forced-swim test.

Behav Brain Res 2019 Feb 16. Epub 2019 Feb 16.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address:

We previously demonstrated that glucagon-like peptide-2 (GLP-2) exerted antidepressant-like effects in mice. The aim of the present study was to investigate the relationship between N-methyl--aspartate (NMDA) receptor-nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway and the antidepressant-like effects of GLP-2 in the forced-swim test (FST) in mice. Intracerebroventricularly administered GLP-2 (3 μg/mouse) decreased the immobility time in the FST. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.028DOI Listing
February 2019

LDL cholesterol relates to depression, its severity, and the prospective course.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 16. Epub 2019 Feb 16.

Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, (Germany.

Background: Major depressive disorder (MDD) is a highly prevalent and burdening mental illness. Approximately 30% of the major depressive episodes (MDE) are classified as therapy-refractory. Further knowledge of the pathophysiological mechanisms underlying MDD and predictive biomarkers are needed to improve treatment options. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.01.010DOI Listing
February 2019

Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene.

Pharmacol Biochem Behav 2019 Feb 16. Epub 2019 Feb 16.

Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:

In humans, mutations in the Disrupted-in-schizophrenia 1 (DISC1) gene have been related to psychiatric disorders, including symptoms of abnormal cognitive and emotional behaviors. In our previous studies, overexpression of the human DISC1 gene in rats resulted in schizophrenia-like phenotypes showing deficits in motor learning, impaired cognitive function and dysfunctions of the dopamine system. Here we asked, whether the DISC1 overexpression affects locomotor activity in the open field (OF), anxiety in the elevated plus-maze (EPM), depression-related behavior in the forced swim test (FST), and attention-like/short-term working-memory in the spontaneous alternation behavior (SAB) in the T-maze in transgenic DISC1 (tgDISC1) rats and littermate controls (WT). Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.005DOI Listing
February 2019

Association of copeptin, a surrogate marker for arginine vasopressin secretion, with insulin resistance: influence of adolescence and psychological stress.

Peptides 2019 Feb 16. Epub 2019 Feb 16.

Department of Medicine, Amager and Hvidovre Hospital in Glostrup, University of Copenhagen, Glostrup, Denmark; Department of Medicine O, Endocrine Unit, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.

In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.005DOI Listing
February 2019

Psychometric properties of the PHQ-9 depression scale in people with multiple sclerosis: A systematic review.

PLoS One 2019 19;14(2):e0197943. Epub 2019 Feb 19.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Background: Depression affects approximately 25% of people with MS (pwMS) at any given time. It is however under recognised in clinical practice, in part due to a lack of uptake for brief assessment tools and uncertainty about their psychometric properties. The 9-item Patient Health Questionnaire (PHQ-9) is an attractive candidate for this role. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197943PLOS
February 2019

Prevalence and determinants of antenatal depression in Ethiopia: A systematic review and meta-analysis.

PLoS One 2019 19;14(2):e0211764. Epub 2019 Feb 19.

Department of Psychiatry, University of Gondar, Gondar, Ethiopia.

Background: Maternal depression is the most prevalent psychiatric disorder during pregnancy, can alter fetal development and have a lasting impact on the offspring's neurological and behavioral development. However, no review has been conducted to report the consolidated magnitude of antenatal depression (AND) in Ethiopia. Therefore, this review aimed to systematically summarize the existing evidence on the epidemiology of AND in Ethiopia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211764PLOS
February 2019

The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation.

Pain 2019 Mar;160(3):658-669

Arthritis Research UK Pain Centre, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.

Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has implications for analgesic treatment strategies. Here, the effect of existing anxiety on future osteoarthritis (OA) pain was investigated, and potential mechanisms were studied in an animal model. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001445DOI Listing

Treating comorbid depression and avoidant personality disorder: The case of Andy.

J Clin Psychol 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry, Institute of Psychotherapy, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Major depressive disorder is among the most frequently diagnosed mental disorders and is often accompanied by other disorders such as anxiety or substance abuse. As a result of a complicated tangle of comorbidities, psychotherapy in such cases can become quite demanding. The present case study presents and discusses the challenges represented by a complex case of psychotherapy, focusing on ongoing modifications of the clinical hypotheses and therapeutic approach. Read More

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http://dx.doi.org/10.1002/jclp.22764DOI Listing
February 2019

Predictors of Adverse Alcohol Use Consequences Among Tertiary Students.

Alcohol Clin Exp Res 2019 Feb 19. Epub 2019 Feb 19.

Melbourne School of Psychological Sciences, University of Melbourne, Parkville, 3010, VIC, Australia.

Background: The alcohol consumption patterns of young adults are of concern. Critically, tertiary students consume greater quantities of alcohol, are at increased risk of injury/harm, and have higher rates of alcohol use disorders (AUD) as compared to their non-university enrolled peers. The Brief Young Adult Alcohol Consequences Questionnaire (BYAACQ) is one of several tools utilised to explore adverse alcohol-related outcomes among tertiary students. Read More

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http://dx.doi.org/10.1111/acer.13988DOI Listing
February 2019

Lung cancer stigma and depression: Validation of the Lung Cancer Stigma Inventory.

Psychooncology 2019 Feb 19. Epub 2019 Feb 19.

University of Arizona.

Objective: In an effort to provide further evidence for the validity of the Lung Cancer Stigma Inventory (LCSI), this paper examined group differences in lung cancer stigma for patients who report clinically significant depressive symptoms and established a suggested scoring benchmark to identify patients with clinically meaningful levels of lung cancer stigma.

Methods: Patients (n=231) who were diagnosed with lung cancer and treated within the past 12 months at one of two NCI-designated Cancer Centers located in the northeast and southern parts of the United States completed a single battery of questionnaires examining lung cancer stigma and depressed mood. Group differences, bivariate correlations and receiver operating characteristics (ROC) analyses were conducted. Read More

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http://dx.doi.org/10.1002/pon.5033DOI Listing
February 2019

The evolutionary response of mating system to heterosis.

J Evol Biol 2019 Feb 19. Epub 2019 Feb 19.

University of Minnesota, Department of Plant and Microbial Biology, Saint Paul, Minnesota, United States.

Isolation allows populations to diverge and to fix different alleles. Deleterious alleles that reach locally high frequencies contribute to genetic load, especially in inbred or selfing populations, in which selection is relaxed. In the event of secondary contact, the recessive portion of the genetic load is masked in the hybrid offspring, producing heterosis. Read More

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http://dx.doi.org/10.1111/jeb.13430DOI Listing
February 2019

Healthcare utilization in patients with first-time implantable cardioverter defibrillators (Data from the WEBCARE study).

Pacing Clin Electrophysiol 2019 Feb 18. Epub 2019 Feb 18.

Department of Cardiology, St. Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.

Background: Knowledge of the level of healthcare utilization (HCU) and the predictors of high HCU use in patients with an implantable cardioverter defibrillator (ICD) is lacking. We examined the level of HCU and predictors associated with increased HCU in first-time ICD patients, using a prospective study design.

Methods: ICD patients (N = 201) completed a set of questionnaires at baseline, 3-, 6-, and 12 months after inclusion. Read More

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http://dx.doi.org/10.1111/pace.13636DOI Listing
February 2019

Sleep disturbance and its relationship with quality of life in older Chinese adults living in nursing homes.

Perspect Psychiatr Care 2019 Feb 19. Epub 2019 Feb 19.

Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China.

Purpose: To examine sleep disturbances in older adults in Macau and Guangzhou, China and their associated factors.

Design And Methods: Four-hundred and thirty seven subjects in Guangzhou and 244 subjects in Macau were interviewed.

Findings: In total, 681 older adults participated in the study, and 27. Read More

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http://dx.doi.org/10.1111/ppc.12363DOI Listing
February 2019

Does frontal brain activity mediates the effect of depression prevention in adolescents? A pilot study.

Int J Psychol 2019 Feb 19. Epub 2019 Feb 19.

University of Tübingen, Tübingen, Germany.

We investigated whether (a) depression prevention was associated with depressive symptoms and medial-frontal alpha asymmetry in adolescents; (b) alpha asymmetry mediated the association between participation in a prevention program and depressive symptoms; and (c) gender affects these associations. In our randomised control group study, we compared a universal prevention program (n = 40 adolescents, 14 females) with a non-intervention control condition (n = 39 adolescents, 20 females) in German secondary school students (mean age: 13.53 years, SD = 0. Read More

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http://dx.doi.org/10.1002/ijop.12573DOI Listing
February 2019

Quality of Life is Markedly Impaired by Rheumatological and Skin Manifestations in Patients with Type 1 Diabetes: A Questionnaire Survey.

Diabetes Ther 2019 Feb 19. Epub 2019 Feb 19.

Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

Introduction: To estimate lifetime prevalence of diabetes-related upper limb and non-acquired skin manifestations in a representative type 1 diabetes (T1D) population and to identify associations between these conditions and quality of life.

Methods: A questionnaire on these complications and measures of quality of life (World Health Organization-Five Well-Being Index [WHO-5]), depression, and diabetes-specific burden (Problem Areas in Diabetes [PAID] scale) was sent to all T1D patients in a Danish clinic (N = 583).

Results: The response rate was 68. Read More

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http://dx.doi.org/10.1007/s13300-019-0587-5DOI Listing
February 2019

EEG-based mild depression recognition using convolutional neural network.

Med Biol Eng Comput 2019 Feb 19. Epub 2019 Feb 19.

Gansu Provincial Key Laboratory of Wearable Computing, School of Information Science and Engineering, Lanzhou University, Lanzhou, China.

Electroencephalography (EEG)-based studies focus on depression recognition using data mining methods, while those on mild depression are yet in infancy, especially in effective monitoring and quantitative measure aspects. Aiming at mild depression recognition, this study proposed a computer-aided detection (CAD) system using convolutional neural network (ConvNet). However, the architecture of ConvNet derived by trial and error and the CAD system used in clinical practice should be built on the basis of the local database; we therefore applied transfer learning when constructing ConvNet architecture. Read More

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http://dx.doi.org/10.1007/s11517-019-01959-2DOI Listing
February 2019

Network Analysis of Behaviors in the Depression and Autism Realms: Inter-Relationships and Clinical Implications.

J Autism Dev Disord 2019 Feb 18. Epub 2019 Feb 18.

Child Study Center, Yale University School of Medicine, 230 S. Frontage Rd, New Haven, CT, 06519, USA.

Depression-, anxiety-, OCD- and autism-related behaviors were assessed in 118 high-functioning individuals with autism spectrum disorders (ASD) and in 2016 controls. The ASD group had a higher rate of clinical depression and markedly higher "insomnia" and "restlessness" scores. Network analysis and hierarchical cluster analysis in the ASD group revealed that depression and anxiety items clustered together, but separately from autism-related items. Read More

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http://dx.doi.org/10.1007/s10803-019-03914-4DOI Listing
February 2019

When Words Fail: Providing Effective Psychological Treatment for Depression in Persons with Aphasia.

J Clin Psychol Med Settings 2019 Feb 18. Epub 2019 Feb 18.

Advanced Studies in Psychology, Kean University, 1000 Morris Ave., Union, NJ, 07083, USA.

More than 2 million people in the United States are living with some form of aphasia, a communication disorder that has been associated with high incidence of clinical depression. Despite their large numbers, persons with aphasia have received little clinical attention from psychologists and other mental health providers. The life participation interventions and supported communication methods developed and routinely employed by speech-language pathologists could assist mental health professionals in addressing the needs of this underserved population. Read More

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http://dx.doi.org/10.1007/s10880-019-09608-4DOI Listing
February 2019

The molecular neurobiology of chronic pain-induced depression.

Cell Tissue Res 2019 Feb 19. Epub 2019 Feb 19.

Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique et Université de Strasbourg, 67000, Strasbourg, France.

The increasing number of individuals with comorbidities poses an urgent need to improve the management of patients with multiple co-existing diseases. Among these comorbidities, chronic pain and mood disorders, two long-lasting disabling conditions that significantly reduce the quality of life, could be cited first. The recent development of animal models accelerated the studies focusing on the underlying mechanisms of the chronic pain and depression/anxiety comorbidity. Read More

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http://dx.doi.org/10.1007/s00441-019-03003-zDOI Listing
February 2019

Multi-database study of multiple sclerosis: identification, validation and description of MS patients in two countries.

J Neurol 2019 Feb 18. Epub 2019 Feb 18.

Boston Collaborative Drug Surveillance Program, Lexington, MA, USA.

Objective: To describe the resources and methods used to identify and validate multiple sclerosis (MS) and match non-MS patients in each of the two databases, and to characterize their demographics, comorbidities and concomitant medications.

Methods: This study was conducted in two separate electronic medical databases, the United States Department of Defense (DOD) military health care system and the United Kingdom's Clinical Practice Research Datalink (CPRD) GOLD. We identified patients with a first recorded diagnosis of MS in 2001-2016 (CPRD) or 2004-2017 (DOD) and matched non-MS patients using algorithms appropriate to each database. Read More

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http://dx.doi.org/10.1007/s00415-019-09238-8DOI Listing
February 2019

Subclinical inflammation and depressive symptoms in patients with type 1 and type 2 diabetes.

Semin Immunopathol 2019 Feb 18. Epub 2019 Feb 18.

German Center for Diabetes Research (DZD), München-Neuherberg, Germany.

Depression is a frequent comorbidity of type 1 diabetes (T1D) and type 2 diabetes (T2D). Depression and diabetes are linked by a bidirectional relationship, but the underlying mechanisms are still incompletely understood. Experimental, observational and intervention studies showed that inflammatory processes contribute to the development of depression in animal models and humans. Read More

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http://dx.doi.org/10.1007/s00281-019-00730-xDOI Listing
February 2019

Parent-Adult Child Relations of Chinese Older Immigrants in the United States: Is There an Optimal Type?

J Gerontol B Psychol Sci Soc Sci 2019 Feb 18. Epub 2019 Feb 18.

Rutgers University, Institute for Health, Health Care Policy and Aging Research, New Brunswick, New Jersey.

Objectives: This study aims to identify 1) different types of parent-child relations among Chinese older immigrants, 2) predictors of each relation type, and 3) the most "optimal" type that is associated with better psychological well-being of the older adults.

Methods: Data were derived from 3,109 Chinese elderly in Chicago. Latent Class Analysis was used to identify structures of parent-child relations based on eight indicators of family solidarity. Read More

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http://dx.doi.org/10.1093/geronb/gbz021DOI Listing
February 2019

Reproductive assurance weakens pollinator-mediated selection on flower size in an annual mixed-mating species.

Ann Bot 2019 Feb 19. Epub 2019 Feb 19.

Grupo de Ecología de la Polinización, Universidad Nacional del Comahue and INIBIOMA-CONICET, Río Negro, Argentina.

Background And Aims: In animal-pollinated plants, direct and indirect selection for large and small flowers in predominantly outcrossing and selfing species, respectively, is a common consequence of pollen limitation (PL). However, many hermaphroditic species show a mixed-mating system known as delayed selfing, which provides reproductive assurance (RA) only when outcrossing is not realized. Although RA is expected to reduce pollinator-mediated selection towards larger flowers, the consequences of delayed selfing for selection on flower size in mixed-mating species remain overlooked. Read More

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http://dx.doi.org/10.1093/aob/mcz014DOI Listing
February 2019

[Personality and depression: A review of theory model and behavior and neural mechanism].

Sheng Li Xue Bao 2019 Feb;71(1):163-172

Key Laboratory of Cognition and Personality (Ministry of Education), Southwest University, Chongqing 400715, China.

The analysis of the relationship between personality and depression can facilitate the development of subclinical preventive measures and clinical treatment schemes. Moreover, the personality is associated with a variety of mental diseases, and there is substantial comorbidity between depression and some other mental diseases. So, to reveal pathological relationships between personality and depression is helpful to understand the etiology of the comorbidity between depression and multiple mental disorders. Read More

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February 2019

[The Figurative Language Test: An instrument for the assessment of concretism in schizophrenic patients].

Vertex 2018 May;XXIX(139):184-191

Servicio de Psiquiatría (31 B), Hospital Borda. Escuela de Posgrado de la Facultad de Medicina de la Universidad del Salvador.

Background: Concretism is a recognized formal thought disorder of schizophrenia, which has been studied clinically by proverb interpretation. To avoid the shortcomings of oral proverbs, there have been developed tests with multiple choice format, which have the advantage of avoiding the disparity of criteria and simplifying its application. In the absence of an equivalent test in Spanish, it is of interest to elaborate a test of this type to be used for clinical and research purposes. Read More

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Treatment Effects following Residential Dialectical Behavior Therapy for Adolescents with Borderline Personality Disorder.

Evid Based Pract Child Adolesc Ment Health 2018 31;3(2):117-128. Epub 2018 May 31.

Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.

Dialectical behavior therapy (DBT) is an empirically supported treatment for borderline personality disorder (BPD) in adults, however fewer studies have examined outcomes in adolescents. This study tested the effectiveness of an intensive 1-month, residential DBT treatment for adolescent girls meeting criteria for BPD. Additionally, given well-established associations between BPD symptoms and childhood abuse, the impact of abuse on treatment outcomes was assessed. Read More

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http://dx.doi.org/10.1080/23794925.2018.1476075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377246PMC

Polychromatic Light Exposure as a Therapeutic in the Treatment and Management of Parkinson's Disease: A Controlled Exploratory Trial.

Front Neurol 2018 19;9:741. Epub 2018 Sep 19.

The Bronowski Institute of Behavioural Neuroscience, The Bronowski Clinic, Coliban Medical Centre, Kyneton, VIC, Australia.

Parkinson's disease (PD) is a disorder characterized by loss of dopamine (DA) in the nigro-striatal dopamine (NSD) system with the primary symptoms of bradykinaesia, rigidity, tremor, and altered gate. Secondary symptoms including depression, insomnia, involuntary movement, and psychiatric side effects are also commonly observed. While the treatment focus for the past 50 years has been aimed at replacing deficient DA, to relieve the primary symptoms, more recent studies have suggested that the circadian system plays a critical role in the etiology and treatment of this disorder. Read More

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http://dx.doi.org/10.3389/fneur.2018.00741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156259PMC
September 2018

Mental Health Literacy of Youth That Have a Family Member With a Mental Illness: Outcomes From a New Program and Scale.

Front Psychiatry 2019 4;10. Epub 2019 Feb 4.

Faculty of Education - Monash, Monash University, Melbourne, VIC, Australia.

A program evaluation examined mental health literacy levels and coping outcomes for youth (ages 10-16), before and at the end of their participation in a manualized, school-based mental health literacy program called Youth Education and Support (YES). Most of the youth reportedly had a parent or other family member with a mental health disorder such as depression, anxiety, and/or substance abuse. The mental health literacy levels of program participants from pre to post were evaluated with the developing Knowledge of Mental Illness and Recovery (K-MIR) scale. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369184PMC
February 2019

Changes in Functional Connectivity Following Treatment With Emotion Regulation Therapy.

Front Behav Neurosci 2019 4;13:10. Epub 2019 Feb 4.

Department of Counseling and Clinical Psychology, Teachers College, Columbia University, New York, NY, United States.

Emotion regulation therapy (ERT) is an efficacious treatment for distress disorders (i.e., depression and anxiety), predicated on a conceptual model wherein difficult to treat distress arises from intense emotionality (e. Read More

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http://dx.doi.org/10.3389/fnbeh.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369363PMC
February 2019

Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models.

Front Cell Neurosci 2019 1;13:24. Epub 2019 Feb 1.

The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.

The main purpose of this study is to explore sex differences in the antidepressant effect of sertraline in genetic knockout or overexpression estrogen-synthesizing enzyme aromatase (Ar) gene mouse models in the forced swim test (FST). Our results demonstrated a significant reduction of depression-like behavior in the mice with overexpression of brain aromatase (Thy1-Ar) compared to sex- and age-matched Ar mice or wild type control mice. Using HPLC analysis, we also found an association between the brain estrogen-related antidepressive behavior and the regulation of serotonin (5-HT) system. Read More

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http://dx.doi.org/10.3389/fncel.2019.00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369353PMC
February 2019

[Genetic comorbidity of depression and somatic disorders].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(1):89-96

Bekhterev National Medical Research Center of Psychiatry and Neurology, St-Petersburg, Russia; Pavlov First St-Petersburg State Medical University, St-Petersburg, Russia.

The aim of our review was to evaluate the perspectives of new therapeutic approaches in comorbid depressive and somatic disorders based on common pathological mechanisms and their genetic risk factors. Literature analysis showed that depression was a complex heterogeneous condition associated with significant prevalence of metabolic, cardiovascular and immune disturbances. The understanding of common molecular mechanisms of risks and course of abovementioned disorders could provide a new strategy for early diagnosis and therapeutic optimization and give the opportunity of 'targeted' approach to different pathological elements. Read More

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http://dx.doi.org/10.17116/jnevro201911901189DOI Listing
January 2019

Comparison of dexmedetomidine and benzodiazepine for intraoperative sedation in elderly patients: a randomized clinical trial.

Reg Anesth Pain Med 2019 Mar 3;44(3):319-324. Epub 2019 Feb 3.

Department of Anesthesiology, Hospital Servidor Público Estadual-Instituto de Assistência Médica ao Servidor Público Estadual, São Paulo, Brazil.

Background And Objectives: Elderly individuals have a greater sensitivity to sedation, and the most commonly used drugs for sedation are benzodiazepines, which exhibit some complication. Therefore, this study aimed to compare the use of dexmedetomidine and midazolam regarding proper sedation and postoperative complications in elderly individuals who require intraoperative sedation.

Methods: This study was a parallel-randomized clinical trial, which included 120 patients aged >70 years undergoing regional anesthesia and sedation. Read More

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http://dx.doi.org/10.1136/rapm-2018-100120DOI Listing

Reduction of PTSD in South African University Students Using Transcendental Meditation Practice.

Psychol Rep 2019 Feb 19:33294119828036. Epub 2019 Feb 19.

Maharishi Institute, Johannesburg, South Africa.

A study was conducted on South African college students using the Transcendental Meditation technique to reduce posttraumatic stress disorder. Students meeting the criteria for possible posttraumatic stress disorder were included. Thirty-four students at the experimental university in South Africa clinically diagnosed with posttraumatic stress disorder were instructed in and practiced the Transcendental Meditation technique twice daily compared to 34 diagnosed posttraumatic stress disorder comparison students at the comparison university. Read More

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http://dx.doi.org/10.1177/0033294119828036DOI Listing
February 2019

Emotion sensitivity across the lifespan: Mapping clinical risk periods to sensitivity to facial emotion intensity.

J Exp Psychol Gen 2019 Feb 18. Epub 2019 Feb 18.

Institute for Technology in Psychiatry, Department of Psychiatry, Division of Depression and Anxiety Disorders, McLean Hospital / Harvard Medical School.

Face emotion perception is important for social functioning and mental health. In addition to recognizing categories of face emotion, accurate emotion perception relies on the ability to detect subtle differences in emotion intensity. The primary aim of this study was to examine participants' ability to discriminate the intensity of facial emotions (emotion sensitivity: ES) in three psychometrically matched ES tasks (fear, anger, or happiness), to identify developmental changes in sensitivity to face emotion intensity across the lifespan. Read More

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http://dx.doi.org/10.1037/xge0000559DOI Listing
February 2019

Urban-Rural Differences in Older Adult Depression: A Systematic Review and Meta-analysis of Comparative Studies.

Am J Prev Med 2019 Feb 15. Epub 2019 Feb 15.

Urban Health Collaborative, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania; Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania.

Context: Depression among older adults (aged 60 years or older) is a problem that could be exacerbated by global trends in urbanization and population aging. The study purpose was to assess whether urban, relative to rural, residence is associated with depression among older adults and whether associations differ in countries with developed versus developing economies.

Evidence Acquisition: In 2017, the authors identified and extracted information from comparative studies of urban-rural depression prevalence among older adults. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.11.008DOI Listing
February 2019

OnabotulinumtoxinA and cognitive behavioral therapy in functional dystonia: A pilot randomized clinical trial.

Parkinsonism Relat Disord 2019 Feb 13. Epub 2019 Feb 13.

Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address:

Introduction: Functional dystonia (FD) is a disabling movement disorder with limited therapeutic options. We aimed to examine the efficacy and safety of chemodenervation with OnabotulinumtoxinA (BoNT) versus placebo prior to cognitive behavioral therapy (CBT) in FD patients.

Methods: FD patients with a Psychogenic Movement Disorders Rating Scale (PMDRS) score ≥ 10 and persistent dystonic posturing for ≥ 1 year were randomized to BoNT or placebo injections prior to 12 weekly individualized 1-h CBT sessions. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.009DOI Listing
February 2019

Commentary on "Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study".

Am J Geriatr Psychiatry 2019 Jan 2. Epub 2019 Jan 2.

Department of Psychiatry and Behavioral Sciences (CKC, KJN), Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1016/j.jagp.2018.12.031DOI Listing
January 2019