472,718 results match your criteria Depression


Cannabis use of patients with inflammatory bowel disease in Germany: a cross-sectional survey.

Z Gastroenterol 2021 Jun 22. Epub 2021 Jun 22.

Department for Internal and Integrative Medicine, Sozialstiftung Bamberg, Bamberg, Germany.

Background And Aims:  Progressive legalization and increasing utilization of medical cannabis open up potential new applications, including for inflammatory bowel disease (IBD). This study aimed to collect current figures on the use of and experience with cannabis among IBD patients in Germany.

Methods:  A 71-item questionnaire was mailed to a randomly selected representative sample of 1000 IBD patients. Read More

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Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials.

Planta Med 2021 Jun 22. Epub 2021 Jun 22.

Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Valencia, Spain.

Depression is a syndrome characterized by deep sadness and the inhibition of psychic functions, sometimes accompanied by neurovegetative disorders, with symptoms of anxiety almost always present. The disease produces alterations in a variety of neural networks and neurotransmission systems, along with a dysfunction of the hypothalamic-pituitary-adrenal axis, which leads to concomitant alterations in the immunological response. Generally, there is a parallel increase in proinflammatory mediators as well as oxidative and nitrosative damage caused by a reduction of antioxidant defenses. Read More

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The risk of depression and anxiety in patients with familial mediterranean fever - a cross-sectional study.

J Affect Disord 2021 Jun 6;292:695-699. Epub 2021 Jun 6.

Division of Psychiatry, Barzilai Medical Center, Ashkelon, Israel.

Background: Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease associated with various systemic comorbidities. Recent research regarding the association with depression and anxiety has yielded conflicting results. The current study aims were to examine whether such an association exists using big data analysis methodology. Read More

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Serum cortisol as a predictor for posttraumatic stress disorder symptoms in post-myocardial infarction patients.

J Affect Disord 2021 Jun 5;292:687-694. Epub 2021 Jun 5.

Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, and University of Zurich, Zurich, Switzerland.

Background: After an acute myocardial infarction (MI), patients may develop posttraumatic stress disorder (PTSD). There is evidence for alterations in the hypothalamic-pituitary-adrenal axis in PTSD. An association between patients` cortisol level after experiencing an MI and subsequent PTSD symptoms has not been investigated yet. Read More

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Sexual health difficulties among service women: the influence of posttraumatic stress disorder.

J Affect Disord 2021 Jun 5;292:678-686. Epub 2021 Jun 5.

Leidos, San Diego, CA, USA; Deployment Health Research Department, Naval Health Research Center, San Diego, CA, USA.

Background Sexual health among service women remains understudied, yet is related to health and quality of life. This study examined if the associations between recent combat and sexual assault with sexual health difficulties were mediated by mental disorders and identified factors associated with sexual health difficulties among service women. Methods Data from two time points (2013 and 2016) of the Millennium Cohort Study, a large military cohort, were used. Read More

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Using the multiple sclerosis resiliency scale to identify psychological distress in persons with multiple sclerosis.

Mult Scler Relat Disord 2021 Jun 11;53:103079. Epub 2021 Jun 11.

Ferkauf Graduate School of Psychology, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY, 10468, USA; Holy Name Medical Center Multiple Sclerosis Center, 718 Teaneck Road, Teaneck, NJ, 07666, USA.

Background: The Multiple Sclerosis Resiliency Scale (MSRS) is the first resilience measure that is specific to multiple sclerosis (MS)-related challenges. In order for the MSRS to be a valuable tool for clinicians, it is important to identify what is a meaningful score. As such, this study aimed to examine the MSRS' ability to identify persons with MS experiencing depression or anxiety symptoms, as determined using clinically significant scores on the Hospital Anxiety and Depression Scale (HADS). Read More

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The association of phasic irritability (aggressive outbursts) and tonic irritability (irritable mood) to depression occurrences, symptoms, and subtypes.

J Affect Disord 2021 Jun 11;293:9-18. Epub 2021 Jun 11.

Vanderbilt University, Nashville, Tennessee.

Background: Research among adults has rarely differentiated between tonic irritability (i.e., irritable mood) and phasic irritability (i. Read More

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Residual symptoms in bipolar disorders: Findings from the bipolar Disorder course and outcome study from India (BiD-CoIN study).

Psychiatry Res 2021 May 14;302:113995. Epub 2021 May 14.

Prosenjit Ghosh.

Aim: To explore the prevalence of residual symptoms (both depressive and manic) and their correlates in subjects with bipolar disorder in clinical remission.

Methodology: This multicentric cross-sectional study included patients in clinical remission recruited across the 14 centers. The patients were evaluated on the Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) for the prevalence of residual symptoms. Read More

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Cognitive effects of rapid-acting treatments for resistant depression: Just adverse, or contributing to clinical efficacy?

J Psychiatr Res 2021 Jun 15;140:512-521. Epub 2021 Jun 15.

Division of Neuropsychiatry, Massachusetts General Hospital and Harvard Medical School, USA.

Major Depressive Disorder is a major public health problem and has a high rate of treatment resistance. Fear conditioning has been proposed as a potential mechanism sustaining negative affect in mood disorders. With the aim of exploring cognitive effects of rapid-acting antidepressant treatments as a potential mechanism of action that can be targeted by neuromodulation, we performed a narrative review of the extant literature on effects of electroconvulsive therapy, ketamine or esketamine, and sleep deprivation on emotional/fear memory retrieval-reconsolidation. Read More

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Is perceived control of depression related to therapy outcome for depression? A longitudinal study.

J Psychiatr Res 2021 Jun 15;140:504-511. Epub 2021 Jun 15.

Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway; Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway.

Background: The present study followed a group of patients over a two-year period after they had received a cognitive behavioral psychoeducational intervention targeting patients' ability to cope with depression. The main aims were to examine whether a change in both depressive symptoms and in the perceived control of depression occurred and the relationship between depressive symptoms and perceived control.

Methods: Using a prospective longitudinal design, a sample of 183 patients was assessed at four time points during a two-year period. Read More

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Smoking status links habenular volume to glycated hemoglobin: Findings from the Human Connectome Project-Young Adult.

Psychoneuroendocrinology 2021 Jun 10;131:105321. Epub 2021 Jun 10.

Center for Depression Research and Clinical Care, UT Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Background: The habenula-pancreas axis regulates the stimulatory effects of nicotine on blood glucose levels and may participate in the emergence of type 2 diabetes in human tobacco smokers. This secondary analysis of young adults from the Human Connectome Project (HCP-YA) evaluated whether smoking status links the relationship between habenular volume and glycated hemoglobin (HbA1c), a marker of long-term glycemic control.

Methods: Habenula segmentation was performed using a fully-automated myelin content-based approach in HCP-YA participants and the results were inspected visually (n = 693; aged 22-37 years). Read More

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Iatrogenic pseudoaneurysm of the superficial temporal artery following craniectomy from a scalp hook retractor penetrating injury: Case report and literature review.

Int J Surg Case Rep 2021 Jun 17;84:106076. Epub 2021 Jun 17.

Department of Neurosurgery, Chi-Mei Medical Center, Tainan, Taiwan; Department of Recreation and Healthcare Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan. Electronic address:

Background: Iatrogenic pseudoaneurysms in scalp vessels are an uncommon complication after cranial surgery. This paper reports a case of scalp pseudoaneurysm in the superficial temporal artery (STA) after forceful hook retraction in craniectomy and reviews the relevant literature.

Case Description: A 36-year-old man with history of hypertension and depression presented to the emergency department with head injury after using sedation medication. Read More

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The effects of reflexology on anxiety, depression and quality of life in patients with gynecological cancers with reference to Watson's theory of human caring.

Complement Ther Clin Pract 2021 Jun 17;44:101428. Epub 2021 Jun 17.

Department of Obstetrics and Gynecology Nursing, Faculty of Health Sciences, Pamukkale University, Kınıklı Campus, Denizli, Turkey. Electronic address:

Objectives: This study aimed to examine the effects of reflexology based on Watson's theory of human caring on anxiety, depression, and quality of life in gynecological cancer patients.

Material And Methods: The study was a prospective, single-blind, randomized controlled trial with a pretest-posttest and a control group. The clinical trial was conducted at a university hospital in the Aegean region between October 2016 and June 2018. Read More

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Green light antinociceptive and reversal of thermal and mechanical hypersensitivity effects rely on endogenous opioid system stimulation.

J Pain 2021 Jun 19. Epub 2021 Jun 19.

Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America; Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, Arizona, 85724 United States of America; Neuroscience Graduate Interdisciplinary Program, College of Medicine, The University of Arizona, Tucson, Arizona, 85742, USA.. Electronic address:

Benefits of phototherapy were characterized in multiple diseases including depression, circadian rhythm disruptions, and neurodegeneration. Studies on migraine and fibromyalgia patients revealed that green light-emitting diodes (GLED) exposure provides a pragmatic and safe therapy to manage chronic pain. In rodents, GLED reversed hypersensitivity related to neuropathic pain. Read More

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Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects.

Neuropharmacology 2021 Jun 19:108679. Epub 2021 Jun 19.

Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of São Paulo, Brazil; Translational Neuropsychiatry Unit (TNU), Department of Clinical Medicine, Aarhus University, Denmark; Department of Biomedicine, Aarhus University, Denmark. Electronic address:

Background And Purpose: Although useful as a rapid-acting antidepressant drug, ketamine is known to induce psychotomimetic effects, which may interfere with its therapeutic use. Cannabidiol (CBD) is a non-psychostimulant compound from Cannabis sativa, which has shown promising antidepressant effects without inducing hyperlocomotion. AMPA receptor activation is involved in the antidepressant effect induced by ketamine, but its relevance for the effects of CBD is not known. Read More

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Therapeutic efficacy of connectivity-directed transcranial magnetic stimulation on anticipatory anhedonia.

Depress Anxiety 2021 Jun 22. Epub 2021 Jun 22.

School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.

Background: There are currently no effective treatments specifically targeting anticipatory anhedonia, a major symptom of severe depression which is associated with poor outcomes. The present study investigated the efficacy of individualized repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex (lDLPFC)-nucleus accumbens (NAcc) network on anticipatory anhedonia in depression.

Methods: This randomized, double-blind, sham-controlled clinical trial (NCT03991572) enrolled 56 depression patients with anhedonia symptoms. Read More

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Prevalence of metabolic syndrome and its correlation with sexual dysfunction in adult psychiatric patients treated with psychotropics in a tertiary care hospital.

Int J Clin Pract 2021 Jun 22:e14559. Epub 2021 Jun 22.

Department of Pharmacy Practice, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, 636008, Tamil Nadu, India.

Background: In the past two decades, there has been a profound increase in the incidence of metabolic disorders among the general population, and psychotropics are also said to play a major role in the development of metabolic syndrome.

Aim: Determining the prevalence of Metabolic Syndrome (MetS) and sexual dysfunction (SD) and their correlation in psychiatric patients treated with psychotropics in a tertiary care hospital in Salem region, Tamilnadu, India.

Materials And Methods: A cross-sectional study was conducted in the psychiatric department of Vinayaka Mission's Medical College and Hospitals, Salem on patients (n=108) treated with psychotropics. Read More

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Anxiety, Depression, and End-of-Life Care Utilization in Adults with Metastatic Cancer.

Psychooncology 2021 Jun 22. Epub 2021 Jun 22.

Department of Psychology, Tulane University, New Orleans, Louisiana, USA.

Objective: End-of-life care for patients with cancer is often overly burdensome, and palliative and hospice care are underutilized. The objective of this study was to evaluate whether the mental health diagnoses of anxiety and depression were associated with variation in end-of-life care in metastatic cancer.

Methods: This study used electronic health data from 1,333 adults with metastatic cancer who received care at two academic health centers in Louisiana, USA, and died between 1/1/2011-12/31/2017. Read More

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Trauma informed interventions: A systematic review.

PLoS One 2021 22;16(6):e0252747. Epub 2021 Jun 22.

School of Nursing, The Johns Hopkins University, Baltimore, Maryland, United States of America.

Background: Health inequities remain a public health concern. Chronic adversity such as discrimination or racism as trauma may perpetuate health inequities in marginalized populations. There is a growing body of the literature on trauma informed and culturally competent care as essential elements of promoting health equity, yet no prior review has systematically addressed trauma informed interventions. Read More

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Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice.

J Clin Invest 2021 Jun 22. Epub 2021 Jun 22.

Department of Neurobiology, Fourth Military Medical University, Xi'an, China.

Patients with neuropathic pain often experience comorbid psychiatric disorders. Cellular plasticity in the anterior cingulate cortex (ACC) is assumed as a critical interface for pain perception and emotion. However, substantial efforts thus far are focused on intracellular mechanisms of plasticity rather than extracellular alterations that might trigger and facilitate intracellular changes. Read More

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The Risk Factors of Psychological Responses for Chinese University Students on COVID-19 Outbreak: A Cross-Sectional Online Survey Study.

J Med Internet Res 2021 Jun 20. Epub 2021 Jun 20.

Department of Neurosurgery, The Fourth Hospital of China Medical University, No. 4 Chongshandong, Huanggu, Shenyang 110084, China., Shenyang, CN.

Background: The novel coronavirus pneumonia (COVID-19) is a highly contagious and highly pathogenic disease caused by a novel coronavirus(SARS-CoV-2)and has become a pandemic. As a vulnerable population, university students are at high-risk during the epidemic because they have high mobility and often overlook the severity of the disease due to incomplete information about the epidemic. The epidemic has brought not only the risk of death from infection but also unbearable psychological pressure. Read More

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Application of machine learning in diagnostic value of mRNAs for bipolar disorder.

Nord J Psychiatry 2021 Jun 22:1-8. Epub 2021 Jun 22.

School of Public Health, Guangxi Medical University, Guangxi, China.

Purpose: Bipolar disorder (BD) is a type of severe mental illness with symptoms of mania or depression, it is necessary to find out effective diagnostic biomarkers for BD due to diagnosing BD is based on clinical interviews without objective indicators.

Materials And Methods: The mRNA expression levels of genes included , and in the peripheral blood of 43 patients with bipolar disorder and 47 healthy controls were detected. Machine learning methods included Artificial Neural Networks, Extreme Gradient Boosting, Random Forest, and Support Vector Machine were adopted to fit different gene combinations to evaluate diagnostic value for bipolar disorder. Read More

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Adolescents Emotional State and Behavioral and Dietary Habit Changes during Isolation Due to the COVID-19 Pandemic.

J Am Coll Nutr 2021 Jun 22:1-9. Epub 2021 Jun 22.

Universidade do Estado do Rio de Janeiro, Núcleo de Estudos da Saúde do Adolescente, Rio de Janeiro, Brazil.

Introduction: The coronavirus disease 2019 (COVID-19) was recognized as a pandemic by the World Health Organization on March 11, 2020. As an infectious disease with no specific treatment, several measures have been established to minimize the outbreak of this disease, including social isolation.

Objective: To evaluate the behavior of adolescents during the isolation period. Read More

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The clinical correlates of the chair sit to stand performance in people with multiple sclerosis.

Physiother Theory Pract 2021 Jun 22:1-12. Epub 2021 Jun 22.

Faculty of Medicine, Department of Neurosciences, Jordan University of Science and Technology, Irbid, Jordan.

: This study aimed to evaluate the motor and non-motor factors associated with sit-to-stand performance in people with Multiple Sclerosis (PwMS). : Observational cross-sectional study. : A total of 88 individuals with MS participated in this study. Read More

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Prevalence of Depression and Anxiety Disorders Following Mild Traumatic Brain Injury.

PM R 2021 Jun 22. Epub 2021 Jun 22.

Kaiser Foundation Rehabilitation Center, Kaiser Permanente Vallejo Medical Center, Vallejo, California.

Introduction: Previous studies have identified an association between traumatic brain injuries and the development of psychiatric disorders in general. However, these studies were subject to limitations that demonstrate the need for a study of a large, clearly defined mild traumatic brain injury (mTBI) population within an integrated healthcare system.

Objective: To determine the prevalence and relative risk of post-injury affective disorders over 4 years following mTBI. Read More

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Behavioural activation for depression in rural Australia: Challenges and opportunities.

Aust J Rural Health 2021 Jun 22. Epub 2021 Jun 22.

School of Nursing Practice and Midwifery, La Trobe University, Melbourne, Vic., Australia.

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Inflammatory bowel disease and depressive symptoms: the prevalence and factors associated with depression in patients with inflammatory bowel disease on intravenous biological therapy - single center experience.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):4008-4016

Department of Gastroenterohepatology, Clinical Center of Montenegro, Podgorica, Montenegro.

Objective: Depression is one of the most commonly occurring psychiatric comorbidities in patients suffering from inflammatory bowel disease (IBD). This study aims to determine prevalence and risk factors for the more severe symptoms of depression (DP) in IBD patients on intravenous biological therapy (IBT).

Patients And Methods: The study consisted of 90 IBD patients who completed a Patient Health Questionnaire-9 (PHQ9) to detect symptoms of depression. Read More

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Psychiatric Outcomes of Childhood Maltreatment: A Retrospective Chart Review from a Children's Psychiatric Inpatient Program.

Child Psychiatry Hum Dev 2021 Jun 22. Epub 2021 Jun 22.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.

Childhood maltreatment is linked to deleterious outcomes, whereby post-traumatic stress disorder (PTSD) has been identified as one of the most debilitating. This retrospective chart review examined whether self-reported affective measures (anxiety, depression, trauma), type of maltreatment (sexual, physical, emotional/verbal abuses), and demographics predicted a diagnosis of anxiety or PTSD among 169 children in a psychiatric inpatient hospital. Secondly, this study identified significant predictors of a PTSD diagnosis. Read More

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