403,509 results match your criteria Depression


[Subjective memory impairments in early detection of dementia: Relation to acceptability of lumbar puncture in memory clinic patients].

Fortschr Neurol Psychiatr 2018 Dec 17. Epub 2018 Dec 17.

Vitos Klinikum Gießen-Marburg, Vitos Klinik für Psychiatrie und Psychotherapie Gießen; Fachbereich Medizin, Philipps-Universität Marburg.

Background: In memory clinics, biomarker-based diagnostic tools for early detection and differential diagnosis of dementia are increasingly important, even if their acceptance by patients is relatively low.

Objective: The aim of study was to examine whether sociodemographic and clinical features of memory clinic patients are associated with acceptance of lumbar puncture (LP). Of particular interest was the patients' self-perception of memory decline (subjective memory impairment, SMI) accompanied by related concerns that might affect decision to consent to LP. Read More

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December 2018

Self-compassion and depression, anxiety, and resilience in adults with epilepsy.

Epilepsy Behav 2018 Dec 14;90:154-161. Epub 2018 Dec 14.

Division of Health Research, Faculty of Health and Medicine, Furness College, Lancaster University, Lancaster LA1 4YG, UK. Electronic address:

Background: Research suggests that people with epilepsy (PWE) are more likely to experience depression and anxiety than the general population. Given the adversity associated with the condition, resilience may also be important. However, to date, resilience has been largely overlooked in the epilepsy literature. Read More

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December 2018

Contingent biofeedback outperforms other methods to enhance the accuracy of cardiac interoception: A comparison of short interventions.

J Behav Ther Exp Psychiatry 2018 Dec 4;63:12-20. Epub 2018 Dec 4.

Institute of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany. Electronic address:

Background And Objectives: Deviations in interoception might contribute to the development and maintenance of mental disorders. The improvement of interoceptive accuracy (IA) is desirable but assessment and training methods remain controversial. For instance, it was assumed that performance increases in heartbeat counting paradigms after cardiac feedback were due to an improvement of knowledge with regard to heart rate rather than due to an actual improvement in IA. Read More

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December 2018

Ambient ozone exposure and depressive symptoms in adolescents: Results of the GINIplus and LISA birth cohorts.

Environ Res 2018 Dec 7;170:73-81. Epub 2018 Dec 7.

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, Ludwig Maximilian University of Munich; Comprehensive Pneumology Center (CPC) Munich, member DZL, German Center for Lung Research, Munich, Germany; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia. Electronic address:

Background: Depression has been associated with air pollution, as reported by animal and epidemiological studies. However, the relationship between ozone exposure and depression, especially among adolescents, is scarcely investigated.

Objectives: The study aimed to analyze associations between ozone exposure and depressive symptoms among German adolescents. Read More

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December 2018

Residential noise exposure and the longitudinal risk of hospitalization for depression after pregnancy: Postpartum and beyond.

Environ Res 2018 Dec 3;170:26-32. Epub 2018 Dec 3.

University of Montreal Hospital Research Centre, 900 Saint Denis St, Montreal, Quebec, Canada H2X 0A9; Institut national de santé publique du Québec, 190 Cremazie Blvd E, Montreal, Quebec, Canada H2P 1E2; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, 1020 Pine Ave W, Montreal, Quebec, Canada H3A 1A2; School of Public Health, University of Montreal, 7101 du Parc Ave, Montreal, Quebec, Canada H3N 1X9. Electronic address:

Objective: Depression is a major public health concern, but the link with the built environment is unclear. We sought to determine the relationship between residential noise during pregnancy and later risk of severe depression in women.

Methods: We analyzed a population-based cohort of 140,456 women with no documented history of mental illness who were pregnant in Montreal between 2000 and 2016. Read More

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December 2018

A tale of two steroids: the importance of the androgens DHEA and DHEAS for early neurodevelopment.

J Steroid Biochem Mol Biol 2018 Dec 14. Epub 2018 Dec 14.

School of Health & Biomedical Sciences, RMIT University - Bundoora Campus, Melbourne, 3083, Australia. Electronic address:

DHEA and DHEAS are neuroactive neurosteroids that interact with several major receptor system in the brain, including sigma (σ), glutamate, and GABA-A receptors. It has been recognized as early as 1952, that the loss of DHEA/DHEAS in adult life is associated with neuropsychiatric disorders (eg schizophrenia, depression). However, the mechanistic role for DHEA/DHEAS in any of these domains remains speculative, not the least because the presence of these androgens in the adrenal gland and brain is largely confined to humans and only some non-human primates. Read More

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December 2018

Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress.

Neuropharmacology 2018 Dec 14. Epub 2018 Dec 14.

Neuroscience Institute, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30303, United States. Electronic address:

Brain-derived neurotrophic factor (BDNF) is known to promote fear learning as well as avoidant behavioral responses to chronic social defeat stress, but, conversely, this peptide can also have antidepressant effects and can reduce depressant-like symptoms such as social avoidance. The purpose of this study was to use a variety of approaches to determine whether BDNF acting on tropomyosin receptor kinase B (TrkB) promotes or prevents avoidant phenotypes in hamsters and mice that have experienced acute social defeat stress. We utilized systemic and brain region-dependent manipulation of BDNF signaling before or immediately following social defeat stress in Syrian hamsters, TrkB knock-in mice, and C57Bl/6J mice and measured the subsequent behavioral response to a novel opponent. Read More

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December 2018

Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression.

Am J Obstet Gynecol 2018 Dec 14. Epub 2018 Dec 14.

Northwestern University, Department of Psychiatry and Behavioral Sciences.

Background: While perinatal depression is one of the most common complications of pregnancy, there is an insufficient understanding of the mechanistic underpinnings of disease. While an association between peripheral inflammatory cytokines and major depressive disorder has been demonstrated, cytokines cannot freely cross the blood brain barrier and thus they give little insight into alternations in brain function. As the brain is in direct communication with the cerebrospinal fluid (CSF), assessment of inflammation in the CSF may be more directly related to the biologic markers of affective change. Read More

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December 2018

The courses of maternal and paternal depressive and anxiety symptoms during the prenatal period in the FinnBrain Birth Cohort study.

PLoS One 2018 17;13(12):e0207856. Epub 2018 Dec 17.

University of Turku, Institute of Clinical Medicine, Turku Brain and Mind Center, FinnBrain Birth Cohort Study, Turku, Finland.

Maternal prenatal symptoms of depression and anxiety have been suggested to impose differential effects on later offspring development, depending on their characteristics, such as timing, intensity and persistence. Paternal symptoms have been less investigated. While knowledge on these trajectory characteristics is essential for improved comprehension of prenatal stress, prospective studies including both expecting parents have been scarce. Read More

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December 2018

Opioid and Cannabis Co-Use among Adults with Chronic Pain: Relations to Substance Misuse, Mental Health, and Pain Experience.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology, University of Houston, Houston, TX (AHR, JB, DJP, MJV); Department of Psychology, Louisiana State University, Baton Rouge, LA (JDB); College of Nursing, Washington State University, Washington, DC (MFO); Department of Psychology, Syracuse University, New York, NY (JWD); Department of Behavioral Science, The University of Texas MD Anderson Cancer Center (MJZ); and HEALTH Institute, University of Houston, Houston, TX (MJZ).

Objectives: Opioid misuse constitutes a significant public health problem and is associated with a host of negative outcomes. Despite efforts to curb this increasing epidemic, opioids remain the most widely prescribed class of medications. Prescription opioids are often used to treat chronic pain despite the risks associated with use, and chronic pain remains an important factor in understanding this epidemic. Read More

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December 2018

Risk and protective factors associated with depressive symptoms in young adults with overweight and obesity.

J Am Coll Health 2018 Dec 17:1-7. Epub 2018 Dec 17.

a Department of Psychology , University of Memphis , Memphis , TN , USA.

Objective: Approximately one-third of college students are categorized as overweight/obese and elevated weight has been associated with increased risk of depressive symptoms. Less is known about protective factors in this context. This study examined associations between depressive symptoms and health behaviors, as well as body image variables among college students with overweight/obesity, while accounting for contributions of BMI and demographics. Read More

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December 2018

Mental health and academic impacts of intimate partner violence among IHE-attending women.

J Am Coll Health 2018 Dec 17:1-8. Epub 2018 Dec 17.

a Institute on Domestic Violence & Sexual Assault, Steve Hicks School of Social Work , The University of Texas at Austin , Austin , TX , USA.

Objective: The study assesses the prevalence of physical, psychological, sexual, and cyber forms of intimate partner violence (IPV) among female college students, and associated mental health and academic outcomes.

Participants: Participants (n = 6,818) were randomly selected female students attending one of eight campuses of a University System in the Southwest. Their mean age was 25, and 45% identified as Hispanic/Latina. Read More

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December 2018

Cortisol levels among older people with and without depression and dementia.

Int Psychogeriatr 2018 Dec 17:1-5. Epub 2018 Dec 17.

Norwegian National Advisory Unit on Ageing and Health,Vestfold Hospital Trust,Tønsberg,Norway.

ABSTRACTCortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample of 650 older people, from the community (home and nursing homes) and specialized care (memory clinics and old age psychiatry wards), mean age 76. Read More

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December 2018

Orthorexia nervosa: A behavioral complex or a psychological condition?

J Behav Addict 2018 Dec 17:1-14. Epub 2018 Dec 17.

1 Psychotherapy and Systems Neuroscience, Justus-Liebig-University Giessen , Giessen, Germany.

Background And Aims: Numerous studies have provided evidence for orthorexia nervosa (ON), an eating pattern characterized by an almost manic obsession for and fixation on healthy eating, to be of epidemiological relevance. However, there is scientific debate on whether it is merely a behavioral or lifestyle phenomenon as compared to a mental disorder. Aim of this cross-sectional study was to explore whether ON is of epidemiological and clinical relevance, and whether ON can be distinguished from other mental health disorders and healthy lifestyle features. Read More

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December 2018

Hospitalization risk factors in antipsychotic-treated schizophrenia, bipolar I disorder or major depressive disorder.

J Comp Eff Res 2018 Dec 17. Epub 2018 Dec 17.

Health Economics and Outcomes Research, Lundbeck, 6 Parkway North, Deerfield, IL 60015, USA.

Aim: To examine hospitalization risk factors in antipsychotic-treated patients with schizophrenia, bipolar I disorder (BD-I) or major depressive disorder (MDD).

Patients & Methods: Using Truven Health MarketScan Commercial, Medicaid and Medicare Supplemental data (01/01/2012-06/30/2016), logistic regression models were performed to identify risk factors for both psychiatric and all-cause hospitalization in three separate analyses.

Results: Significant risk factors included prior hospitalization (schizophrenia: odds ratio [95% CI]: 2. Read More

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December 2018

Hope and its dimensions in relation to clinical recovery: A cross-sectional study among people with psychotic disorders.

Psychiatr Rehabil J 2018 Dec 17. Epub 2018 Dec 17.

First Department of Psychiatry, Institute of Psychiatry and Neurology.

Objective: Hope is a key component of personal recovery. There is limited evidence regarding the association of hope with the level of functioning in individuals with psychosis. It is also not clear which dimensions of hope are most strongly related to clinical recovery. Read More

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December 2018

Comparing anxiety and depression to obesity and smoking as predictors of major medical illnesses and somatic symptoms.

Health Psychol 2018 Dec 17. Epub 2018 Dec 17.

San Francisco VA Medical Center.

Objective: Anxiety and depression predict poor physical health longitudinally, but are neglected in primary care settings compared to other risk factors such as obesity and smoking. Further, anxiety has been less commonly studied than depression, and whether anxiety has unique predictive effects for physical health is unknown. We compared anxiety and depression to obesity and smoking as predictors of physical health indices and examined unique predictive effects of anxiety and depression. Read More

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December 2018

Collective ethnic-racial identity and health outcomes among African American youth: Examination of promotive and protective effects.

Cultur Divers Ethnic Minor Psychol 2018 Dec 17. Epub 2018 Dec 17.

Community Evaluation and Research Collaborative, Michigan State University.

Objectives: Racial discrimination is associated with numerous negative health outcomes, including increased risk for depression and anxiety symptoms and substance use. Positive affect toward of one's ethnic or racial group (i.e. Read More

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December 2018

Care prior to and during subsequent pregnancies following stillbirth for improving outcomes.

Cochrane Database Syst Rev 2018 Dec 17;12:CD012203. Epub 2018 Dec 17.

NHMRC Centre of Research Excellence in Stillbirth, Mater Research Institute - The University of Queensland (MRI-UQ), Level 3 Aubigny Place, Mater Health Services, Brisbane, Queensland, Australia, 4101.

Background: Stillbirth affects at least 2.6 million families worldwide every year and has enduring consequences for parents and health services. Parents entering a subsequent pregnancy following stillbirth face a risk of stillbirth recurrence, alongside increased risks of other adverse pregnancy outcomes and psychosocial challenges. Read More

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December 2018

Long-term efficacy of Metacognitive Training for Depression (D-MCT): A randomized controlled trial.

Br J Clin Psychol 2018 Dec 16. Epub 2018 Dec 16.

Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Germany.

Objectives: The availability of treatment for depression needs to be improved. Among the barriers are the dearth of group programmes and the high demand of many programmes with regard to staff expertise. The Metacognitive Training for Depression (D-MCT) is a new, easy-to-administer, cognitive behaviour-based group intervention. Read More

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December 2018

The Prevalence and Psychological Cost of Interpersonal Violence in Graduate and Law School.

J Interpers Violence 2018 Dec 17:886260518816329. Epub 2018 Dec 17.

2 Middle Tennessee State University, Murfreesboro, USA.

There is a rich research literature linking interpersonal violence to mental health disorders among undergraduate students. However, scholars know less about the prevalence and consequences of victimization among students enrolled in postbaccalaureate programs. Graduate and law students are uniquely vulnerable in their dependence on programs for financial support and career advancement, and they are more isolated than undergraduates. Read More

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December 2018

Siblings of Young People With Cancer in NZ: Experiences That Positively and Negatively Support Well-Being.

J Pediatr Oncol Nurs 2018 Dec 17:1043454218819455. Epub 2018 Dec 17.

1 The University of Auckland, Auckland, New Zealand.

Siblings of young people with cancer experience significant distress and these effects often exist long after their sibling's treatment has successfully been completed. In New Zealand, many families must travel several hours to receive treatment, with some having to live away from home for extended periods which can create additional strains. We interviewed 10 siblings of pediatric cancer survivors drawn from a larger quantitative study, to investigate what made siblings' experiences more difficult and to find out what was helpful in supporting their adjustment. Read More

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December 2018

An Affront to Her Mana: Young Māori Mothers' Experiences of Intimate Partner Violence.

J Interpers Violence 2018 Dec 17:886260518815712. Epub 2018 Dec 17.

3 Katoa Ltd, Auckland, New Zealand.

Young Māori mothers in Aotearoa/New Zealand are disproportionately vulnerable to intimate partner violence (IPV) due to multiple intersecting factors, such as relationship dynamics during youth, pregnancy, and racialized Māori (Indigenous) identity. An enduring legacy of settler colonialism has resulted in Māori being overrepresented as victims and perpetrators of violence. IPV, in particular, leads to adverse social, mental, and health outcomes over time, including those specific to mothers (e. Read More

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December 2018

Pilot RCT of a social media parenting intervention for postpartum mothers with depression symptoms.

J Reprod Infant Psychol 2018 Dec 17:1-12. Epub 2018 Dec 17.

b Policylab: Center to Bridge Research Practice, & Policy , The Children's Hospital of Philadelphia, Roberts Center for Pediatric Research , Philadelphia , PA , USA.

Objective: This pilot study describes the adaptation of a parenting group intervention for social media, and examines the feasibility, acceptability and initial outcomes of the adapted intervention for mothers with postpartum depression symptoms.

Background: Postpartum depression can negatively affect parenting and the parent-infant relationship. Mothers with postpartum depression symptoms experience barriers to access in-person parenting interventions. Read More

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December 2018

Enrichment of pathogenic variants in genes associated with inborn errors of metabolism in psychiatric populations.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 16. Epub 2018 Dec 16.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

Many genetic conditions can mimic mental health disorders, with psychiatric symptoms that are difficult to treat with standard psychotropic medications. This study tests the hypothesis that psychiatric populations are enriched for pathogenic variants associated with selected inborn errors of metabolism (IEMs). Using next-generation sequencing, 2046 psychiatric patients were screened for pathogenic variants in genes associated with four IEMs, Niemann-Pick disease type C (NPC), Wilson disease (WD), homocystinuria (HOM), and acute intermittent porphyria (AIP). Read More

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December 2018

'I Am Worthless and Kind'; the specificity of positive and negative self-evaluation in adolescent depression.

Br J Clin Psychol 2018 Dec 16. Epub 2018 Dec 16.

School of Psychology and Clinical Language Sciences, University of Reading, UK.

Objectives: Adolescence represents a critical phase when the concept of self is developed and consolidated. Depressed adolescents globally endorse more negative and fewer positive self-descriptive words compared with non-depressed adolescents. Yet, the methods used have not allowed for more detailed exploration of the specific content of these self-endorsements. Read More

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December 2018

Dissection method affects electrophysiological properties of hippocampal slices.

Oruen 2017 Dec;3(2):94-101

Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

The rodent hippocampal slice preparation has long been a critical tool for studying the electrophysiological effects of pharmacological and genetic manipulations. Slices can be prepared with several different slicing methods including the tissue chopper, vibratome, and rotary slicer. To examine how slicing methods affect slice integrity, we generated hippocampal slices by these three methods and compared their histology and electrophysiological responses. Read More

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December 2017

Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging.

Front Mol Biosci 2018 28;5:106. Epub 2018 Nov 28.

UNICAEN, INSERM, COMETE, Normandie University, Caen, France.

The N-methyl-D-Aspartate glutamate receptors (NMDARs) are pivotal for the functional and morphological plasticity that are required in neuronal networks for efficient brain activities and notably for cognitive-related abilities. Because NMDARs are heterogeneous in subunit composition and associated with multiple functional regulatory sites, their efficacy is under the tonic influence of numerous allosteric modulations, whose dysfunction generally represents the first step generating pathological states. Among the enzymatic candidates, serine racemase (SR) has recently gathered an increasing interest considering that it tightly regulates the production of d-serine, an amino acid now viewed as the main endogenous co-agonist necessary for NMDAR activation. Read More

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November 2018

A Prospective Longitudinal Study of Marriage from Midlife to Later Life.

Couple Family Psychol 2018 Mar;7(1):12-21

Indiana University Purdue University Indianapolis.

This prospective longitudinal study explores the relationship between marital functioning at midlife and in later life as measured by global coding of marital interaction process. Couples participated in home interviews at midlife, then again 25 years later. During home interviews at both waves couples completed a questionnaire describing their family, then discussed differences of opinion about the family. Read More

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Visual rating assessment of cerebral atrophy and its relationship with cognitive function in chronic obstructive pulmonary disease.

BMJ Open Respir Res 2018 26;5(1):e000310. Epub 2018 Nov 26.

Academic Respiratory Unit, Clinical Sciences, University of Bristol, Bristol, UK.

Introduction: Widespread white matter damage and cognitive impairment have been demonstrated in chronic obstructive pulmonary disease (COPD). However, it remains unclear if brain atrophy is a global phenomenon or if specific subregions are differentially affected. The aims of this study are, first, to test a simple, validated visual analogue grading technique. Read More

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November 2018

Sub-zero temperature mechanically stable low molecular weight hydrogels.

J Mater Chem B 2018 Nov 2;6(44):7274-7279. Epub 2018 Aug 2.

School of Chemistry , University of Glasgow , Glasgow , G12 8QQ , UK . Email:

We show here a low molecular weight hydrogelator based on a functionalised-dipeptide which is stable down to temperatures of -12 °C despite being made from >99% water. This stabilty at low temperature can be extended to ∼-40 °C by gelling water : glycerol mixtures. The temperature range is wider than that of the glycerol : water mixtures alone. Read More

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November 2018

Improving psychotherapies offered in public hospitals in Nairobi, Kenya: extending practice-based research model for LMICs.

Int J Ment Health Syst 2018 11;12:76. Epub 2018 Dec 11.

3Department of Behavioural Sciences and Learning, Linköping University, Linköping, Sweden.

Background: Psychotherapy and mental health services in Nairobi's public hospitals are increasing. Rather than prematurely imposing psychotherapy protocols developed in Western countries to Kenya, we argue that first studying psychological interventions as they are practiced may generate understanding of which psychological problems are common, what interventions therapists use, and what seems to be effective in reducing psychiatric problems in a lower and middle income country like Kenya.

Method: We present preliminary findings from a process-outcome study involving 345 patients from two public institutions, Kenyatta National and Mathare National Hospitals. Read More

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December 2018

Metabolic, Mental and Immunological Effects of Normoxic and Hypoxic Training in Multiple Sclerosis Patients: A Pilot Study.

Front Immunol 2018 29;9:2819. Epub 2018 Nov 29.

Experimental and Clinical Research Center Cooperation Between Charité Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine, Berlin, Germany.

Physical activity might attenuate inflammation and neurodegeneration in multiple sclerosis (MS). Erythropoietin, which is produced upon exposure to hypoxia, is thought to act as a neuroprotective agent in MS. Therefore, we studied the effects of intermittent hypoxic training on activity energy expenditure, maximal workload, serum erythropoietin, and immunophenotype focusing on regulatory and IL-17A-producing T cells. Read More

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November 2018

Plasma Protein Pattern Correlates With Pain Intensity and Psychological Distress in Women With Chronic Widespread Pain.

Front Psychol 2018 29;9:2400. Epub 2018 Nov 29.

Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Although generalized muscle pain, tiredness, anxiety, and depression are commonly present among chronic widespread pain (CWP) patients, the molecular mechanisms behind CWP are not fully elucidated. Moreover, the lack of biomarkers often makes diagnosis and treatment problematic. In this study, we investigated the correlation between pain intensity, psychological distress, and plasma proteins among CWP patients and controls (CON). Read More

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November 2018

A Multilevel Analysis of Job Characteristics, Emotion Regulation, and Teacher Well-Being: A Job Demands-Resources Model.

Front Psychol 2018 29;9:2395. Epub 2018 Nov 29.

Faculty of Education, Northeast Normal University, Changchun, China.

This study integrated personal factors into the job demands-resources (JD-R) model to examine school- and individual-level predictors of teacher well-being. Survey data were gathered from 1,656 teachers from 54 schools. The results of hierarchical linear modeling indicated that the school-level emotional job demands of teaching and suppression at the individual level were positively related to teachers' anxiety and depression whereas school-level trust in colleagues and individual-level reappraisal were positively associated with enthusiasm and contentment. Read More

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November 2018

Exploring the Incorporation of a Positive Psychology Component in a Cognitive Behavioral Internet-Based Program for Depressive Symptoms. Results Throughout the Intervention Process.

Front Psychol 2018 29;9:2360. Epub 2018 Nov 29.

Department of Basic Psychology, Clinic and Psychobiology, Universitat Jaume I, Castellón, Spain.

Traditionally, evidence-based treatments for depression have focused on negative symptoms. Different authors describe the need to include positive affect as a major target of treatment. Positive psychology aims to fill this gap. Read More

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November 2018

Cerebellar Contributions to Major Depression.

Front Psychiatry 2018 29;9:634. Epub 2018 Nov 29.

Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.

Extending beyond the motor domain, the cerebellum is involved in various aspects of cognition and affect. Multidisciplinary evidence has demonstrated topographic organization of higher-order cognitive functions within the cerebellum. We here review recent neuroimaging research that indicates cerebellar contributions to major depressive disorder (MDD). Read More

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November 2018

Distinct Bleaching Resilience of Photosynthetic Plastid-Bearing Mollusks Under Thermal Stress and High CO Conditions.

Front Physiol 2018 30;9:1675. Epub 2018 Nov 30.

MARE - Marine and Environmental Sciences Centre, Laboratório Marítimo da Guia - Faculdade de Ciências da Universidade de Lisboa, Cascais, Portugal.

The impact of temperature on photo-symbiotic relationships has been highly studied in the tropical reef-forming corals but overlooked in less charismatic groups such as solar-powered sacoglossan sea slugs. These organisms display one of the most puzzling symbiotic features observed in the animal kingdom, i.e. Read More

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November 2018

Vanadium Dioxide Circuits Emulate Neurological Disorders.

Front Neurosci 2018 30;12:856. Epub 2018 Nov 30.

School of Materials Engineering, Purdue University, West Lafayette, IN, United States.

Information in the central nervous system (CNS) is conducted via electrical signals known as action potentials and is encoded in time. Several neurological disorders including depression, Attention Deficit Hyperactivity Disorder (ADHD), originate in faulty brain signaling frequencies. Here, we present a Hodgkin-Huxley model analog for a strongly correlated VO artificial neuron system that undergoes an electrically-driven insulator-metal transition. Read More

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November 2018

Assessment of pain-related fear in individuals with chronic painful conditions.

J Pain Res 2018 30;11:3071-3077. Epub 2018 Nov 30.

Australian Research Centre for Population Oral Health, Adelaide Dental School, The University of Adelaide, Adelaide, SA, Australia,

Background: Heightened fear and anxiety related to pain may result in emotional and behavioral avoidance responses causing disability, distress, and depression. Fear and anxiety associated with pain can potentially change the course of the pain experience. It is plausible that fear and anxiety related to pain affect the duration and frequency of pain experienced by the patient. Read More

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November 2018

Correlates of Treatment Readiness among Formerly Incarcerated Homeless Women.

Crim Justice Behav 2018 Jul 15;45(7):969-983. Epub 2018 May 15.

Treatment readiness is a key predictor of drug treatment completion, rearrest, and recidivism during community reentry; however, limited data exists among homeless, female ex-offenders (HFOs). The purpose of this study was to present baseline data from a randomized controlled trial of 130 HFOs who had been released from jail or prison. Over half (60. Read More

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Wiring the depressed brain: optogenetic and chemogenetic circuit interrogation in animal models of depression.

Neuropsychopharmacology 2018 Dec 5. Epub 2018 Dec 5.

Department of Psychology, McGill University, Montréal, QC, Canada.

The advent of optogenetics and chemogenetics has revolutionized the study of neural circuit mechanisms of behavioral dysregulation in psychiatric disease. These powerful technologies allow manipulation of specific neurons to determine causal relationships between neuronal activity and behavior. Optogenetic tools have been key to mapping the circuitry underlying depression-like behavior in animal models, clarifying the contribution of the ventral tegmental area, nucleus accumbens, medial prefrontal cortex, ventral hippocampus, and other limbic areas, to stress susceptibility. Read More

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December 2018

Self-reported physical activity levels and clinical progression in early Parkinson's disease.

Parkinsonism Relat Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Introduction: This study investigates longitudinal changes in self-reported physical activity, measured by Physical Activity Scale of the Elderly (PASE), in early Parkinson's disease (PD) and matched healthy control (HC) participants in the Parkinson's Progression Marker Initiative (PPMI) and evaluates associations between physical activity and PD progression.

Methods: PPMI is a prospective, longitudinal study evaluating markers of progression in PD participants who are unmedicated at enrollment. PASE, a self-reported measure of physical activity, was administered to early PD (N = 380) and HC (N = 174). Read More

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December 2018

Effects of family-centred care interventions on preterm infants and parents in neonatal intensive care units: A systematic review and meta-analysis of randomised controlled trials.

Aust Crit Care 2018 Dec 13. Epub 2018 Dec 13.

Department of Nursing, Hunan Children's Hospital, Changsha, Hunan Province, People's Republic of China; School of Nursing and Midwifery, Faculty of Health and Human Sciences, University of Plymouth, Plymouth, UK. Electronic address:

Objective: The objective of this study was to review English and Chinese randomised controlled trials (RCTs) to determine the effects of family-centred care (FCC) interventions on preterm infants' and parental outcomes in the neonatal intensive care units and to conduct a meta-analysis.

Review Method Used: Systematic review and meta-analysis.

Data Sources: Medline, CINAHL, Embase, PsycINFO, BNI, and AMED and the Chinese databases CNKI and Wanfang Data were searched in April 2017 and updated in August 2018. Read More

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December 2018

Electroconvulsive therapy induced gray matter increase is not necessarily correlated with clinical data in depressed patients.

Brain Stimul 2018 Dec 4. Epub 2018 Dec 4.

Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Background: Electroconvulsive therapy (ECT) and depression have been associated with brain volume changes, especially in the hippocampus and the amygdala.

Methods: In this retrospective study we collected data from individual pre-post ECT whole brain magnetic resonance imaging scans of depressed patients from six German university hospitals. Gray matter volume (GMV) changes were quantified via voxel-based morphometry in a total sample of 92 patients with major depressive episodes (MDE). Read More

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December 2018

Leptin gene polymorphisms are associated with weight gain during lithium augmentation in patients with major depression.

Eur Neuropsychopharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

Weight gain is a common adverse effect of lithium augmentation. Previous studies indicate an impact of genetic variants at the leptin gene on weight gain as a consequence of psychopharmacological treatment. The primary aim of our study was to identify variants at the leptin locus that might predict lithium-induced weight gain. Read More

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December 2018

Concussion Incidence, Duration, and Return to School and Sport in 5- to 14-Year-Old American Football Athletes.

J Pediatr 2018 Dec 12. Epub 2018 Dec 12.

Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA; Department of Pediatrics, University of Washington, Seattle, WA; Harborview Injury Prevention and Research Center, Seattle, WA.

Objective: To collect prospective data on concussion incidence, risk factors, duration of symptoms, and return to school and sport in 5- to 14-year-old American football participants.

Study Design: We conducted a prospective cohort study over 2 years collecting data during two 10-week fall seasons. Youth with concussion were followed to determine time to return to school, sport, and baseline level of symptoms. Read More

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December 2018

Subdural hematoma and electroconvulsive therapy: A case report and review of the literature.

Neurochirurgie 2018 Dec 13. Epub 2018 Dec 13.

Department of neurosurgery, Hospices civils de Lyon, Hospital for neurology and neurosurgery Pierre Wertheimer, 69003, Lyon, France; Université de Lyon, Université Claude-Bernard, 69003, Lyon, France; Inserm U1127, CNRS 7225, Brain and spine institute, 75006, Paris, France; Sorbonne Universités, université Pierre et Marie Curie, 75005, Paris, France.

Background And Case Presentation: Electroconvulsive therapy (ECT) is a common therapeutic procedure in psychiatry associated with a low rate of complications. We report a rare case of subdural hematoma (SDH) associated with ECT.

Clinical Presentation: a 64 year old woman, with a medical history of persistent depression which required ECT six years previously, underwent ECT following a new acute episode. Read More

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December 2018