411,983 results match your criteria Depression


Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study.

Int Arch Allergy Immunol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Augsburg, Germany,

Background: Psychosocial factors are supposed to play a central role in the development of allergic diseases. Associations with seasonal and perennial forms of allergies have not been investigated, yet.

Objectives: The aim of the study was to investigate the associations of psychosocial factors (social status, depression, generalized anxiety, psychosocial stress, Type-D personality) with seasonal, perennial, and other forms of allergies in adults. Read More

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https://www.karger.com/Article/FullText/499042
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http://dx.doi.org/10.1159/000499042DOI Listing
April 2019
1 Read

The Relationship between Expected Engagement and Talking Therapy Outcome.

Clin Psychol Psychother 2019 Apr 24. Epub 2019 Apr 24.

Department of Psychology, University of Sheffield.

The aim of the study was to investigate whether client-reported expected engagement with therapy predicted therapy outcome. It was hypothesised that higher expected engagement with cognitive behavioural therapy (CBT) or person-centred experiential therapy (PCET) would predict more symptomatic improvement following therapy and higher likelihood of therapy completion. The Sheffield Expected Engagement with Therapy Scale (ShEETS) was administered to 96 clients at pre-therapy assessment with all meeting a diagnosis of moderate or severe depression with 53 receiving CBT and 43 receiving PCET. Read More

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http://dx.doi.org/10.1002/cpp.2369DOI Listing

Alcohol use and risk factors for self-harm behavior in Spanish adolescents.

Adicciones 2019 Mar 29;0(0):1239. Epub 2019 Mar 29.

Universidad de Oviedo.

Self-harm behaviors in children and adolescents constitute an important public health problem with prevalence figures in the clinical population between 40 and 80%. The objectives of the study were to analyze and compare the Spanish sub-samples of two studies, SEYLE and WE-STAY to determine prevalence, self-harm patterns and factors associated with self-harm behaviors, notably the use of alcohol or drugs. The questionnaires used in both studies were the Global School Health Survey (GSHS), the Beck Depression Inventory (BDI-II), the Strengths and Difficulties Questionnaire (SDQ). Read More

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http://dx.doi.org/10.20882/adicciones.1239DOI Listing

The complexity of the interaction between binge-eating and attention.

PLoS One 2019 24;14(4):e0215506. Epub 2019 Apr 24.

Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.

Objective: To investigate whether binge-eating in patients with eating disorders (EDs) is associated with attentional deficits.

Methods: We studied ED patients with binge-eating (n = 51), no binge-eating (n = 59) and controls (n = 58). ED patients were assessed following the stabilization of weight and ED pathology. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215506PLOS

Infant crying and the calming response: Parental versus mechanical soothing using swaddling, sound, and movement.

PLoS One 2019 24;14(4):e0214548. Epub 2019 Apr 24.

Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands.

Background: Frequent infant crying is associated with parental exhaustion, depression, or even infant hospitalization and shaken baby syndrome. Effective prompt soothing methods are lacking for infants under 6 months. We examined whether swaddling, sound, and movement evoked an immediate calming response (CR) when parents soothed their infants and using a smart crib, and whether infant age affected the CR. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214548PLOS

Methanol stem bark extract of Adansonia digitata ameliorates chronic unpredictable mild stress-induced depression-like behavior: Involvement of the HPA axis, BDNF, and stress biomarkers pathways.

J Basic Clin Physiol Pharmacol 2019 Apr 24. Epub 2019 Apr 24.

Department of Pharmacognosy and Drug Development, Ahmadu Bello University, Zaria, Nigeria.

Background Adansonia digitata L. (Malvaceae) is used locally in the management of depressive illnesses, and its antidepressant-like effect has been previously reported. The present study was aimed at determining the effect of the methanol extract of the stem bark of A. Read More

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http://dx.doi.org/10.1515/jbcpp-2018-0153DOI Listing

Effect of Depressive Symptoms and Sex on the Relationship Between Loneliness and Cigarette Dependence: A Moderated Mediation.

J Psychol 2019 Apr 24:1-13. Epub 2019 Apr 24.

a University of Santiago de Compostela.

Loneliness is a subjective and emotionally unpleasant experience of perceiving insufficient social relationships. Previous research has revealed that loneliness constitutes a psychosocial risk factor for depression, and is also related to unhealthy behaviors such as smoking. This study aims to examine the relation between loneliness, depression, and cigarette dependence, and to explore the role of sex in this relationship. Read More

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http://dx.doi.org/10.1080/00223980.2019.1598929DOI Listing

ACYLOXYACYL HYDROLASE MODULATES DEPRESSIVE-LIKE BEHAVIORS THROUGH ARYL HYDROCARBON RECEPTOR.

Am J Physiol Regul Integr Comp Physiol 2019 Apr 24. Epub 2019 Apr 24.

Urology, Northwestern University, United States.

Corticotropin-releasing factor (CRF) regulates stress responses, and aberrant CRF signals are associated with depressive disorders. expression is responsive to arachidonic acid (AA), where CRF is released from the hypothalamic paraventricular nucleus (PVN) to initiate the hypothalamic-pituitary-adrenal axis, culminating in glucocorticoid stress hormone release. Despite this biologic and clinical significance, regulation is unclear. Read More

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http://dx.doi.org/10.1152/ajpregu.00029.2019DOI Listing

Trends in Treatment and Spending for Patients Receiving Outpatient Treatment of Depression in the United States, 1998-2015.

JAMA Psychiatry 2019 Apr 24. Epub 2019 Apr 24.

Department of Health Policy and Management, Emory University, Atlanta, Georgia.

Context: After marked increases from 1987 to 1997, trends in depression treatment in the United States increased modestly from 1998 to 2007. However, multiple policy changes that expanded insurance coverage for mental health conditions may have shifted these trends again since 2007.

Objective: To examine national trends in outpatient treatment of depression from 1998 to 2015, with particular focus on 2007 to 2015. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0633DOI Listing

Seasonality Patterns of Internet Searches on Mental Health: Exploratory Infodemiology Study.

JMIR Ment Health 2019 Apr 24;6(4):e12974. Epub 2019 Apr 24.

Anxiety Treatment and Research Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Background: The study of seasonal patterns of public interest in psychiatric disorders has important theoretical and practical implications for service planning and delivery. The recent explosion of internet searches suggests that mining search databases yields unique information on public interest in mental health disorders, which is a significantly more affordable approach than population health studies.

Objective: This study aimed to investigate seasonal patterns of internet mental health queries in Ontario, Canada. Read More

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http://dx.doi.org/10.2196/12974DOI Listing

The Effectiveness of Hypnosis Intervention in Alleviating Postpartum Psychological Symptoms.

Am J Clin Hypn 2019 Apr;61(4):409-425

b University of Malaya , Kuala Lumpur , Malaysia.

Psychological symptoms, particularly postpartum depression, may impair women's well-being after childbirth. Mind-body treatments such as hypnosis are available to help prepare women to maintain or improve their well-being postpartum. The aims of the present study are to determine the effectiveness of a hypnosis intervention in alleviating psychological symptoms (stress, anxiety, and depression) and the symptoms of postpartum depression. Read More

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http://dx.doi.org/10.1080/00029157.2018.1538870DOI Listing

The Most Beautiful Man: An Integration of Hypnosis and Biofeedback for Depression and Dissociation.

Authors:
Donald Moss

Am J Clin Hypn 2019 Apr;61(4):322-334

a Saybrook University , Oakland , CA.

Hypnosis and biofeedback techniques are evidence-based psychophysiological therapies that can be applied with a wide variety of medical and mental health disorders. Research shows efficacy for anxiety, depression, post-traumatic stress disorder (PTDS), chronic pain, hypertension, fibromyalgia, and a host of other disorders. Hypnosis and biofeedback can also augment the effectiveness of psychotherapy. Read More

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http://dx.doi.org/10.1080/00029157.2018.1517082DOI Listing

Heterogeneous Patterns of Marijuana Use Motives Using Latent Profile Analysis.

Subst Use Misuse 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Department of Psychology , University of North Texas , Denton , Texas , USA.

Background: Given that marijuana use is often associated with detrimental physical and mental health problems, research examining motives for its use is critical for effective remedial and preventive treatment. To date, the majority of research on marijuana use motives has used variable-centered analyses, which overlooks potentially meaningful heterogeneous response patterns and the associations of those patterns with other risk/protective factors.

Methods: To address this gap, in the current study, we conducted a person-centered analysis (latent profile analysis) to identify subgroups of participants based on endorsed marijuana use motives, and examined the construct validity of the optimal class solution (covariates included sociodemographic (e. Read More

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https://www.tandfonline.com/doi/full/10.1080/10826084.2019.1
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http://dx.doi.org/10.1080/10826084.2019.1588325DOI Listing
April 2019
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Validity of the CES-D for depression screening in military service members with a history of mild traumatic brain injury.

Brain Inj 2019 Apr 24:1-9. Epub 2019 Apr 24.

b Defense and Veterans Brain Injury Center (DVBIC) San Antonio VA Polytrauma Rehabilitation Center, South Texas Veterans Healthcare System , San Antonio , Texas , USA.

Primary Objective: To advance knowledge about the value of the Center for Epidemiologic Studies - Depression scale (CES-D) for depression screening in military service members with a history of mild traumatic brain injury (mTBI).

Research Design: Retrospective data from 336 military service members with a history of mTBI were extracted from a TBI Repository at a large military medical center. Participants included in this study screened positive for mTBI in a primary care clinic or soldier readiness processing center and were enrolled in the TBI repository from November 6, 2014 to May 31, 2017. Read More

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http://dx.doi.org/10.1080/02699052.2019.1610191DOI Listing

Cortisol awakening response and additive serotonergic genetic risk interactively predict depression in two samples: The 2019 Donald F. Klein Early Career Investigator Award Paper.

Depress Anxiety 2019 Apr 24. Epub 2019 Apr 24.

Human Development and Social Policy Program, School of Education & Social Policy and Cells to Society Center, Institute for Policy Research, Northwestern University, Evanston, Illinois.

Background: The serotonin system and hypothalamic pituitary-adrenal (HPA)-axis are each implicated in the pathway to depression; human and animal research support these systems' cross-talk. Our work implicates a 5-variant additive serotoninergic multilocus genetic profile score (MGPS) and separately the cortisol awakening response (CAR) in the prospective prediction of depression; other work has shown that the serotonin transporter polymorphism 5HTTLPR predicts CAR and interacts with the CAR to predict depression.

Methods: We tested the hypothesis that a 6-variant MGPS (original plus 5HTTLPR) would interact with CAR to predict prospective depressive episode onsets in 201 emerging adults using four annual follow-up interviews. Read More

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http://dx.doi.org/10.1002/da.22899DOI Listing

Depressive Symptoms in Asymptomatic Stage B Heart Failure with Type II Diabetic Mellitus.

Clin Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Medicine, University of California, La Jolla, CA.

Background: The presence of concomitant Type II diabetic mellitus (T2DM) and depressive symptoms adversely affects individuals with symptomatic heart failure (HF). Hypothesis In presymptomatic Stage B HF, this study hypothesized the presence of greater inflammation and depressive symptoms in T2DM as compared to non-T2DM Stage B patients.

Methods: This cross-sectional study examined clinical parameters, inflammatory biomarkers, and depressive symptoms in 349 T2DM and non-T2DM men with asymptomatic stage B HF (mean age 66. Read More

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http://dx.doi.org/10.1002/clc.23187DOI Listing

Problem-solving intervention to prevent depression in non-professional caregivers: a randomized controlled trial with 8 years of follow-up.

Psychol Med 2019 Apr 24:1-8. Epub 2019 Apr 24.

Department of Clinical Psychology and Psychobiology,University of Santiago de Compostela,Santiago de Compostela,Spain.

Background: Studies of psychological interventions for the prevention of depression have found significant effects in the short-term, but the long-term efficacy has yet to be determined. This study evaluated the 8-year effect of a randomized controlled trial for indicated prevention of depression in female caregivers.

Methods: A total of 173 non-professional female caregivers with subclinical depressive symptoms not meeting criteria for a major depressive episode (MDE) were randomized to either a brief problem-solving intervention (n = 89) or usual-care control group (n = 84). Read More

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http://dx.doi.org/10.1017/S0033291719000916DOI Listing

Mindfulness and wellbeing in older adults' survivors of herdsmen attack. The mediating effect of positive reappraisal.

Aging Ment Health 2019 Apr 24:1-9. Epub 2019 Apr 24.

a Department of Psychology , University of Nigeria , Nsukka , Nigeria.

Objective: The Fulani herdsmen are pastoralists who move from place to place in search of vegetation for their herds cattle. The random movement of cattle has frequently led to the destruction of crops belonging to farmers. This has resulted to violent clashes between the two groups. Read More

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http://dx.doi.org/10.1080/13607863.2019.1602592DOI Listing

Association of plasma leptin, pro-inflammatory adipokines and cancer-related fatigue in early-stage breast cancer patients: A prospective cohort study.

J Cell Mol Med 2019 Apr 23. Epub 2019 Apr 23.

Department of Pharmacy, National University of Singapore, Singapore.

Cancer-related fatigue (CRF) is subjective and has wide inter-individual variability. Given that leptin is commonly associated with fatigue syndrome, its use as a potential biomarker for CRF is being investigated. The primary objective of this study was to evaluate the association between leptin and CRF in early-stage breast cancer patients receiving chemotherapy. Read More

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http://dx.doi.org/10.1111/jcmm.14319DOI Listing

Feeding in the frequency domain: coarser-grained environments increase consumer sensitivity to resource variability, covariance and phase.

Ecol Lett 2019 Apr 23. Epub 2019 Apr 23.

Theoretical Aquatic Ecology and Ecophysiology group, Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.

Theory predicts that resource variability hinders consumer performance. How this effect depends on the temporal structure of resource fluctuations encountered by individuals remains poorly understood. Combining modelling and growth experiments with Daphnia magna, we decompose the complexity of resource fluctuations and test the effect of resource variance, supply peak timing (i. Read More

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http://dx.doi.org/10.1111/ele.13267DOI Listing

Demographic, Cannabis Use, and Depressive Correlates of Cannabis Use Consequences in Regular Cannabis Users.

Am J Addict 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan.

Background And Objectives: Regular cannabis users experience cannabis-related consequences across many domains of functioning. The present study examined demographic, cannabis use, and depressive correlates of cannabis consequences. We hypothesized that (1) earlier onset of use would predict greater psychological and functional consequences; and (2) women would endorse more psychological and withdrawal consequences. Read More

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http://dx.doi.org/10.1111/ajad.12889DOI Listing

Stepwise treatment of acute bipolar depression.

Bipolar Disord 2019 Apr 23. Epub 2019 Apr 23.

Treatment Algorithm Group.

One of the most controversial mood disorder management topics is how to manage bipolar depression, as evidenced by varying guidelines and, in particular, whether antidepressants should be prescribed. In relation to the latter, the first issue is that of efficacy while the second issue is their potential 'cost' in that they may induce switching (into a hypo/manic state) or the induction of a mixed state and/or also worsen the long-term pattern of the disorder. Both issues are worthy of consideration before generating a framework of recommended treatment model. Read More

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http://dx.doi.org/10.1111/bdi.12780DOI Listing

Exposure to caring parenting and adult mental health in extremely low birthweight survivors.

J Paediatr Child Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Aim: Individuals born at extremely low birthweight (ELBW; <1000 g) are exposed to early adversities that increase the risk of mental health problems in later life. Caring parenting has been shown to offset the negative effects of early adversity in general population samples. However, the long-term impact of caring parenting on the mental health of preterm survivors in adulthood is not known. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jpc.14476
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http://dx.doi.org/10.1111/jpc.14476DOI Listing
April 2019
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New-onset insomnia among cancer patients undergoing chemotherapy: prevalence, risk factors, and its correlation with other symptoms.

Sleep Breath 2019 Apr 23. Epub 2019 Apr 23.

Faculty of Nursing, Phenikaa University, Hanoi, Vietnam.

Study Objectives: Although insomnia is common among cancer patients, its prevalence remains variable, and its risk factors and correlation with other cancer-related symptoms are not fully explored in the literature. This study aims to determine the prevalence and severity of insomnia as well as risk factors and sleep-related symptom clusters in a sample of cancer patients.

Methods: A cross-sectional survey was conducted collecting data from 213 cancer patients undergoing chemotherapy (age = 53. Read More

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http://dx.doi.org/10.1007/s11325-019-01839-xDOI Listing

Adverse Respiratory Events Increase Post-anesthesia Care Unit Stay in China: A 2-year Retrospective Matched Cohort Study.

Curr Med Sci 2019 Apr 23;39(2):325-329. Epub 2019 Apr 23.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Despite growing attention to patients' safety worldwide, no data were available on the impact of adverse respiratory events (AREs) on post-anesthesia care and post-operation care in China. This study evaluated the occurrence of AREs, the impact of AREs on length of stay (LOS) in post-anesthesia care unit (PACU) and postoperative time in hospital, and PACU cost and inpatient healthcare costs. A retrospective, matched-cohort study was conducted by prospectively collecting the data of 159 AREs in PACU during 2016-2017 in an university hospital in China. Read More

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http://dx.doi.org/10.1007/s11596-019-2038-yDOI Listing

Neuropsychiatric Symptoms, Parenting Stress and Social Support in Chinese Mothers of Children with Autism Spectrum Disorder.

Curr Med Sci 2019 Apr 23;39(2):291-297. Epub 2019 Apr 23.

Department of Pediatrics, Union Hospital of Fujian Medical University, Fuzhou, 350001, China.

Although little is known about the current situation regarding autism spectrum disorder (ASD) in mainland China, psychiatric disorders are common among Chinese mothers of preschool children with ASD. Previous studies showed ASD child's behavioral symptoms, maternal anxiety, and maternal depressive symptoms were associated with overall parenting stress in northern China. In the present study, we retrospectively analyzed medical records at the hospital related to neuropsychiatric symptoms, parenting stress and social support in mothers of children with ASD from southern China. Read More

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http://link.springer.com/10.1007/s11596-019-2033-3
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http://dx.doi.org/10.1007/s11596-019-2033-3DOI Listing
April 2019
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Adversity in childhood and depression in pregnancy.

Arch Womens Ment Health 2019 Apr 23. Epub 2019 Apr 23.

Faculty of Nursing, University of Calgary, 2500 University Dr. N.W, Calgary, Alberta, T2N 1N4, Canada.

Adverse childhood experiences (ACEs) have been found to be associated with various health conditions; however, there is dearth of evidence on the relationship between ACEs and prenatal depression. This study was conducted to determine the association between overall ACE score and prenatal depression symptoms, assess the moderating effect of social support and partner support on this relationship, and determine the association between individual ACE scores and prenatal depression. A secondary analysis was conducted of data from an RCT that assessed the feasibility of e-screening for maternal mental health among 636 pregnant women recruited from antenatal clinics. Read More

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http://dx.doi.org/10.1007/s00737-019-00966-4DOI Listing

Prenatal maternal personality as an early predictor of vulnerable parenting style.

Arch Womens Ment Health 2019 Apr 23. Epub 2019 Apr 23.

Institute for Social Science Research, The University of Queensland, Brisbane, Australia.

Perinatal mental health problems, particularly depression, are prevalent and have been a central focus of prevention initiatives. The greater proportion of ongoing annual perinatal mental health economic cost burdens relate to children. A key linking mechanism is mother-infant relationship quality. Read More

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http://dx.doi.org/10.1007/s00737-019-00963-7DOI Listing

Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice.

Basic Res Cardiol 2019 Apr 23;114(3):26. Epub 2019 Apr 23.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, 07745, Jena, Germany.

Sepsis-induced myocardial depression (SIMD) is an early and frequent consequence of the infection-induced systemic inflammatory response syndrome. In homiotherms, variations in ambient temperature (T) outside the thermoneutral zone induce thermoregulatory responses mainly driven by a gradually increased sympathetic activity, which may affect disease severity. We hypothesized that thermoregulatory responses upon reduced T exposition aggravate SIMD in mice. Read More

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http://dx.doi.org/10.1007/s00395-019-0734-1DOI Listing

Epidemiological and Clinical Gender Differences in OCD.

Curr Psychiatry Rep 2019 Apr 23;21(5):36. Epub 2019 Apr 23.

Department of Psychology, Florida State University, PO Box 3064301, Tallahassee, FL, 32306, USA.

Purpose Of Review: This review highlights recent research regarding gender differences in OCD, with a focus on prevalence, course of illness, symptom presentation, comorbidity, and treatment response.

Recent Findings: Overall, findings remain mixed. OCD may be more common among males in childhood, but is more common among females in adolescence and adulthood. Read More

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http://dx.doi.org/10.1007/s11920-019-1015-2DOI Listing

Psychological profiles in patients undergoing orthognathic surgery or rhinoplasty: a preoperative and preliminary comparison.

Oral Maxillofac Surg 2019 Apr 23. Epub 2019 Apr 23.

Division of Maxillofacial Surgery, Universita degli Studi del Piemonte Orientale Amedeo Avogadro, Novara, Italy.

Objective: The aim of this study was to assess, identify, and compare the personality traits and psychosocial status of two groups of patients undergoing orthognathic surgery and rhinoseptoplasty respectively.

Study Design: This prospective study recruited patients referred for orthognathic surgery and for rhinoseptoplasty. The research protocol included the administrations of questionnaires to the patients during their last visit before surgery, including the Minnesota Multiphasic Personality Inventory (MMPI-2), the Myers-Briggs Type Indicator (MBTI), the tree drawing test (or Baum test), and the BC Scale. Read More

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http://dx.doi.org/10.1007/s10006-019-00758-1DOI Listing

[Depressive symptoms in early rheumatoid arthritis : Within the rheumatism network ADAPTHERA].

Z Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

ACURA Rheumazentrum Rheinland-Pfalz, Kaiser-Wilhelm-Straße 9-11, 55543, Bad Kreuznach, Deutschland.

Background And Objective: For patients with established rheumatoid arthritis and also early arthritis an increased prevalence of depression has been described. For a better understanding of depression in early arthritis patients, depression prevalences of a German early arthritis cohort were examined, with a focus on disease activity, anti-CCP status, disease duration and functional capacity over a period of 2 years.

Material And Methods: The evaluation was based on the early arthritis cohort ADAPTHERA from Rhineland-Palatinate. Read More

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http://dx.doi.org/10.1007/s00393-019-0596-9DOI Listing

Effectiveness of Acupuncture Used for the Management of Postpartum Depression: A Systematic Review and Meta-Analysis.

Biomed Res Int 2019 20;2019:6597503. Epub 2019 Mar 20.

Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China.

Background: Previous studies have demonstrated that acupuncture was an effective alternative for treating major depressive disorders. However, the use of acupuncture for the treatment of postpartum depression remains controversial. This review summarizes the most significant studies in the area of acupuncture treatment for postpartum depression and provides a detailed overview of the efficacy of acupuncture for the treatment of postpartum depression. Read More

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http://dx.doi.org/10.1155/2019/6597503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446093PMC

Expanding the role of Australian pharmacists in community pharmacies in chronic pain management - a narrative review.

Pharm Pract (Granada) 2019 Jan-Mar;17(1):1410. Epub 2019 Feb 18.

School of Health and Biomedical Sciences, Discipline of Pharmacy, RMIT University. Bundoora, VIC (Australia).

Chronic pain is a condition where patients continuously experience pain symptoms for at least 3 to 6 months. It is one of the leading causes of disabilities across the globe. Failure to adequately manage chronic pain often results in additional health concerns that may directly contribute to the worsening symptoms of pain. Read More

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http://dx.doi.org/10.18549/PharmPract.2019.1.1410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463420PMC
February 2019

Associated factors for depressive disorder in patients with end-stage renal disease treated with continuous ambulatory peritoneal dialysis.

Ther Clin Risk Manag 2019 1;15:541-548. Epub 2019 Apr 1.

Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand,

Background: The aim of this study was to primarily determine factors associated with the depressive disorders in continuous ambulatory peritoneal dialysis (CAPD).

Methods: CAPD patients were recruited from the chronic kidney disease and CAPD Clinic of University Hospital. The stable CAPD patients for at least 3 months were included in the study. Read More

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http://dx.doi.org/10.2147/TCRM.S186394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448535PMC

Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy.

Neuropsychiatr Dis Treat 2019 28;15:753-761. Epub 2019 Mar 28.

Department of Psychology, Chung Shan Medical University, Taichung, Taiwan,

Purpose: This cross-sectional pilot study aimed to compare the effects of chemotherapy and targeted therapy on neuropsychological performance and psychiatric symptoms in patients with non-small-cell lung cancer (NSCLC).

Patients And Methods: A total of 113 patients with NSCLC were recruited. According to their type of cancer treatment, the patients were classified into chemotherapy (n=40), targeted therapy (n=33), and untreated control (n=40) groups. Read More

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http://dx.doi.org/10.2147/NDT.S194642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446983PMC

Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent.

Nat Biomed Eng 2018 Dec 3;2(12):907-914. Epub 2018 Dec 3.

Vascular Bionics Laboratory, Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Parkville, Victoria, Australia.

Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson's disease, depression, epilepsy and other neurological disorders. However, access to the brain requires invasive procedures, such as the removal of a portion of the skull or the drilling of a burr hole. Also, electrode implantation into tissue can cause inflammatory tissue responses and brain trauma, and lead to device failure. Read More

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http://dx.doi.org/10.1038/s41551-018-0321-zDOI Listing
December 2018

Spiking Neural Network Modelling Approach Reveals How Mindfulness Training Rewires the Brain.

Sci Rep 2019 Apr 23;9(1):6367. Epub 2019 Apr 23.

Division of Psychology, Nottingham Trent University, Nottingham, United Kingdom.

There has been substantial interest in Mindfulness Training (MT) to understand how it can benefit healthy individuals as well as people with a broad range of health conditions. Research has begun to delineate associated changes in brain function. However, whether measures of brain function can be used to identify individuals who are more likely to respond to MT remains unclear. Read More

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http://dx.doi.org/10.1038/s41598-019-42863-xDOI Listing

Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition.

Sci Rep 2019 Apr 23;9(1):6456. Epub 2019 Apr 23.

Mind and Brain Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.

Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) paradigm to assess whether mice lacking the pro-inflammatory caspase 1, interferon gamma-receptor, and nitric oxide synthase (Casp1, Ifngr, Nos2) present altered depressive- and anxiety-like behaviour at baseline and in response to CUS. Read More

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http://dx.doi.org/10.1038/s41598-018-38055-8DOI Listing

Manual or electroacupuncture as an add-on therapy to SSRIs for depression: A randomized controlled trial.

J Psychiatr Res 2019 Apr 9;114:24-33. Epub 2019 Apr 9.

Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese Medicine, Beijing, 100029, China. Electronic address:

Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants, however, only around 60% of patients could benefit from them. Acupuncture is supported by insufficient evidence to help with symptom relieving and SSRIs tolerance. This pragmatic randomized controlled trial compared SSRIs alone versus SSRIs together with manual acupuncture (MA) or electroacupuncture (EA) in moderate to severe depressed patients. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.04.005DOI Listing

Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine.

Neuropharmacology 2019 Apr 20. Epub 2019 Apr 20.

Pfizer Worldwide Research & Development, 1 Portland Street, Cambridge, MA, 02139, United Kingdom. Electronic address:

Ketamine is a rapid-onset antidepressant whose efficacy long outlasts its pharmacokinetics. Multiple studies suggest ketamine's antidepressant effects require increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-dependent currents, which have recently been exclusively attributed to its N-methyl-D-aspartate receptor-inactive metabolite (2R,6R)-hydroxynorketamine ((2R,6R)-HNK). To investigate this AMPAR-activation claim further, we estimated and evaluated preclinically and clinically relevant unbound brain HNK concentrations (C). Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.019DOI Listing

[Alitretinoin (Toctino): A French follow-up study of harmacovigilance].

Therapie 2019 Mar 31. Epub 2019 Mar 31.

Centre régional de pharmacovigilance, centre-Val-de-Loire, service de pharmacosurveillance, CHRU de Tours, 37044 Tours, France. Electronic address:

Introduction: The adverse reaction profile of alitretinoin, a retinoid indicated in severe topical corticosteroid-refractory chronic hand eczema, is similar to that of other oral retinoids, especially isotretinoin. The objective of this study was to detect new adverse effects (not listed) of alitretinoin and to estimate the number of pregnancies exposed.

Material And Methods: All cases of ADR reported in France with alitretinoin between October 1st, 2012 and February 29th, 2016 were analysed. Read More

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http://dx.doi.org/10.1016/j.therap.2019.02.006DOI Listing

Self-reported prevalence and severity of opioid and kratom (Mitragyna speciosa korth.) side effects.

J Ethnopharmacol 2019 Apr 20:111876. Epub 2019 Apr 20.

Centre for Drug Research, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia.

Ethnopharmacological Relevance: Mitragyna speciosa (Korth.) is a traditional medicinal plant widely used in Southeast Asia for its opioid-like effects. Although kratom produces analgesia through binding of mitragynine and other alkaloids at the mu-opioid receptor (MOR), the association of long-term kratom use with adverse opioid-like effects remains unknown. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111876DOI Listing

Loss to follow-up after laparoscopic gastric bypass surgery - a post hoc analysis of a randomized clinical trial.

Surg Obes Relat Dis 2019 Mar 20. Epub 2019 Mar 20.

Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. Electronic address:

Background: Follow-up after bariatric surgery is important if we are to identify long-term complications at an early stage and thereby improve long-term outcome. Despite great efforts, many patients are lost to follow-up. Definition of characteristics of patients failing to attend follow-up could help in defining a specific group for whom extra resources may be applied to improve the situation. Read More

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http://dx.doi.org/10.1016/j.soard.2019.03.010DOI Listing

A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 20. Epub 2019 Apr 20.

Bipolar Disorder Program (PROMAN), Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.

Mental disorders are highly prevalent and important causes of medical burden worldwide. Co-occurrence of neurological and psychiatric symptoms are observed among mental disorders, representing a challenge for their differential diagnosis. Psychiatrists and neurologists have faced challenges in diagnosing old adults presenting behavioral changes. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.04.008DOI Listing

Effect of tele-rehabilitation on glucose control, exercise capacity, physical fitness, muscle strength and psychosocial status in patients with type 2 diabetes: A double blind randomized controlled trial.

Prim Care Diabetes 2019 Apr 20. Epub 2019 Apr 20.

Baskent University, Faculty of Health Sciences, Department of Physical Therapy and Rehabilitation, Ankara, Turkey.

Aim: To determine the effect of a tele-rehabilitation (TR) program on glucose control, exercise capacity, physical fitness, muscle strength and psychosocial status in patients with type 2 diabetes mellitus (DM).

Method: Fifty type 2 DM participants were enrolled in the study and divided randomly into two groups; TR (n = 25, mean age: 52.82 ± 11. Read More

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http://dx.doi.org/10.1016/j.pcd.2019.03.007DOI Listing

Low socioeconomic status and depression: A double jeopardy for cardiovascular disease?

J Psychosom Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1016/j.jpsychores.2019.04.011DOI Listing